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Hyperpolarized Carbon 13 Magnetic Resonance Imaging And Spectroscopy

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Hyperpolarized Carbon 13 Magnetic Resonance Imaging and Spectroscopy

Hyperpolarized Carbon 13 Magnetic Resonance Imaging and Spectroscopy Book
Author : Peder Larson
Publisher : Academic Press
Release : 2021-10-01
ISBN : 0128222700
Language : En, Es, Fr & De

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Book Description :

MRI with hyperpolarized carbon-13 agents is a powerful emerging imaging modality that can measure real-time metabolism in cells, animals, and humans. It uses endogenous, non-toxic contrast agents that a hyperpolarized, resulting in up to 100,000-fold increases in sensitivity. This technique uses no ionizing radiation, and is being applied in a range of human trials. It’s primary use is for metabolic imaging, but it can also measure perfusion, pH, and necrosis. Hyperpolarized Carbon-13 Magnetic Resonance Imaging and Spectroscopy is designed to be a one stop shop for understanding hyperpolarized 13C MRI. This book explains the principles of this imaging modality, the requirements for performing studies, shows how to interpret the results, and gives an overview of current biomedical applications. It is suitable for engineers, scientists and clinicians in radiology and biomedical imaging who want to understand this technology. Presents the physics and hardware of dissolution dynamic nuclear polarization Explains the behaviour of hyperpolarized carbon-13 agents and how to image them Detailed guidance on experimental design and data interpretation Identifies promising and potential applications of hyperpolarized carbon-13 MR

Functional and Molecular Imaging in Oncology An Issue of Magnetic Resonance Imaging Clinics of North America

Functional and Molecular Imaging in Oncology  An Issue of Magnetic Resonance Imaging Clinics of North America  Book
Author : Antonio Luna
Publisher : Elsevier Health Sciences
Release : 2016-01-19
ISBN : 0323416993
Language : En, Es, Fr & De

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Book Description :

This issue of MRI Clinics of North America focuses on Functional MRI in Oncology. Articles will include: Functional MRI techniques in oncology in the era of personalized medicine, MRI biomarkers and surrogate endpoints in oncology clinical trials, Therapy monitoring with functional MRI, Multiparametric MRI in the assessment of brain tumors, Multiparametric MRI of breast cancer, Functional MRI in chest malignancies, Multiparametric MRI in abdominal malignancies, Assessment of musculoskeletal malignancies with functional MRI, Evaluation of head and neck tumors with functional MRI, Role of multiparametric MRI in malignancies of the urogenital tract, Diffusion-weighted imaging in oncology, Functional MRI in gynecologic cancer, Assessment of angiogenesis with MRI: DCE-MRI and beyond, Imaging of tumor metabolism: MR spectroscopy, and more!

Quantitative Magnetic Resonance Imaging

Quantitative Magnetic Resonance Imaging Book
Author : Nicole Seiberlich,Vikas Gulani,Adrienne Campbell-Washburn,Steven Sourbron,Mariya Ivanova Doneva,Fernando Calamante,Houchun Harry Hu
Publisher : Academic Press
Release : 2020-11-27
ISBN : 0128170581
Language : En, Es, Fr & De

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Book Description :

Quantitative Magnetic Resonance Imaging is a ‘go-to’ reference for methods and applications of quantitative magnetic resonance imaging, with specific sections on Relaxometry, Perfusion, and Diffusion. Each section will start with an explanation of the basic techniques for mapping the tissue property in question, including a description of the challenges that arise when using these basic approaches. For properties which can be measured in multiple ways, each of these basic methods will be described in separate chapters. Following the basics, a chapter in each section presents more advanced and recently proposed techniques for quantitative tissue property mapping, with a concluding chapter on clinical applications. The reader will learn: The basic physics behind tissue property mapping How to implement basic pulse sequences for the quantitative measurement of tissue properties The strengths and limitations to the basic and more rapid methods for mapping the magnetic relaxation properties T1, T2, and T2* The pros and cons for different approaches to mapping perfusion The methods of Diffusion-weighted imaging and how this approach can be used to generate diffusion tensor maps and more complex representations of diffusion How flow, magneto-electric tissue property, fat fraction, exchange, elastography, and temperature mapping are performed How fast imaging approaches including parallel imaging, compressed sensing, and Magnetic Resonance Fingerprinting can be used to accelerate or improve tissue property mapping schemes How tissue property mapping is used clinically in different organs Structured to cater for MRI researchers and graduate students with a wide variety of backgrounds Explains basic methods for quantitatively measuring tissue properties with MRI - including T1, T2, perfusion, diffusion, fat and iron fraction, elastography, flow, susceptibility - enabling the implementation of pulse sequences to perform measurements Shows the limitations of the techniques and explains the challenges to the clinical adoption of these traditional methods, presenting the latest research in rapid quantitative imaging which has the possibility to tackle these challenges Each section contains a chapter explaining the basics of novel ideas for quantitative mapping, such as compressed sensing and Magnetic Resonance Fingerprinting-based approaches

Molecular Characterization of Autophagic Responses Part B

Molecular Characterization of Autophagic Responses Part B Book
Author : Anonim
Publisher : Academic Press
Release : 2017-02-22
ISBN : 0128097949
Language : En, Es, Fr & De

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Book Description :

Molecular Characterization of Autophagic Responses, Part B presents a collection of methods for the qualitative and quantitative evaluation of virtually all the morphological, biochemical, and functional manifestations of autophagy, in vitro, ex vivo and in vivo, in organisms as distant as yeast and man. Autophagy is an evolutionarily conserved mechanism for the lysosomal degradation of superfluous or dangerous cytoplasmic entities, and plays a critical role in the preservation of cellular and organismal homeostasis. Monitoring the biochemical processes that accompany autophagy is fundamental for understanding whether autophagic responses are efficient or dysfunctional. Offers a detailed overview of the protocols used to study autophagy and various aspects of autophagic responses Written in an accessible style by renowned experts in the field

Quantitative MRI in Cancer

Quantitative MRI in Cancer Book
Author : Thomas E. Yankeelov,David R. Pickens,Ronald R. Price
Publisher : Taylor & Francis
Release : 2011-09-13
ISBN : 1439820589
Language : En, Es, Fr & De

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Book Description :

Propelling quantitative MRI techniques from bench to bedside, Quantitative MRI in Cancer presents a range of quantitative MRI methods for assessing tumor biology. It includes biophysical and theoretical explanations of the most relevant MRI techniques as well as examples of these techniques in cancer applications. The introductory part of the book covers basic cancer biology, theoretical aspects of NMR/MRI physics, and the hardware required to form MR images. Forming the core of the book, the next three parts illustrate how to characterize tissue properties with endogenous and exogenous contrast mechanisms and discuss common image processing techniques relevant for cancer. The final part explores emerging areas of MR cancer characterization, including radiation therapy planning, cellular and molecular imaging, pH imaging, and hyperpolarized MR. Each of the post-introductory chapters describes the salient qualitative and quantitative aspects of the techniques before proceeding to preclinical and clinical applications. Each chapter also contains references for further study. Leading the way toward more personalized medicine, this text brings together existing and emerging quantitative MRI techniques for assessing cancer. It provides a self-contained overview of the theoretical and experimental essentials and state of the art in cancer MRI.

Imaging and Metabolism

Imaging and Metabolism Book
Author : Jason S. Lewis,Kayvan R. Keshari
Publisher : Springer
Release : 2017-09-25
ISBN : 3319614010
Language : En, Es, Fr & De

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Book Description :

This book presents advanced molecular imaging techniques used to assess metabolic function. Covering state-of-the art modalities, it discusses the evaluation of a wide range of diseases that have a metabolic component, including cancer, inflammatory conditions, diabetes, neurodegeneration, and cardiovascular disorders. Imaging provides a quantitative perspective to the assessment of metabolic function and complements genetic analysis of disorders related to disrupted metabolism. Organized into four parts, the book highlights basic principles in molecular imaging techniques; metabolic imaging approaches, including magnetic resonance imaging (MRI), single-photon emission computed tomography (SPECT), positron emission tomography (PET), and hybrid modalities; metabolic diseases; and future perspectives. Featuring contributions from leading authorities in radiology, oncology, cardiology, and neurology, Imaging and Metabolism is a pioneering exploration of the role of imaging modalities in assessing the physiological status of abnormal cells and diagnosing disease.

Handbook of Magnetic Resonance Spectroscopy In Vivo

Handbook of Magnetic Resonance Spectroscopy In Vivo Book
Author : Paul A. Bottomley,John R. Griffiths
Publisher : John Wiley & Sons
Release : 2016-12-19
ISBN : 1118997662
Language : En, Es, Fr & De

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Book Description :

This handbook covers the entire field of magnetic resonance spectroscopy (MRS), a unique method that allows the non-invasive identification, quantification and spatial mapping of metabolites in living organisms–including animal models and patients. Comprised of three parts: Methodology covers basic MRS theory, methodology for acquiring, quantifying spectra, and spatially localizing spectra, and equipment essentials, as well as vital ancillary issues such as motion suppression and physiological monitoring. Applications focuses on MRS applications, both in animal models of disease and in human studies of normal physiology and disease, including cancer, neurological disease, cardiac and muscle metabolism, and obesity. Reference includes useful appendices and look up tables of relative MRS signal-to-noise ratios, typical tissue concentrations, structures of common metabolites, and useful formulae. About eMagRes Handbooks eMagRes (formerly the Encyclopedia of Magnetic Resonance) publishes a wide range of online articles on all aspects of magnetic resonance in physics, chemistry, biology and medicine. The existence of this large number of articles, written by experts in various fields, is enabling the publication of a series of eMagRes Handbooks on specific areas of NMR and MRI. The chapters of each of these handbooks will comprise a carefully chosen selection of eMagRes articles. In consultation with the eMagRes Editorial Board, the eMagRes Handbooks are coherently planned in advance by specially-selected Editors, and new articles are written to give appropriate complete coverage. The handbooks are intended to be of value and interest to research students, postdoctoral fellows and other researchers learning about the scientific area in question and undertaking relevant experiments, whether in academia or industry. Have the content of this handbook and the complete content of eMagRes at your fingertips! Visit the eMagRes Homepage

50th ENC Conference

50th ENC Conference Book
Author : Anonim
Publisher : Unknown
Release : 2009
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download 50th ENC Conference book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Chemical Abstracts

Chemical Abstracts Book
Author : Anonim
Publisher : Unknown
Release : 2002
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Chemical Abstracts book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

In Vivo NMR Spectroscopy

In Vivo NMR Spectroscopy Book
Author : Robin A. de Graaf
Publisher : John Wiley & Sons
Release : 2019-03-11
ISBN : 1119382548
Language : En, Es, Fr & De

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Book Description :

Presents basic concepts, experimental methodology and data acquisition, and processing standards of in vivo NMR spectroscopy This book covers, in detail, the technical and biophysical aspects of in vivo NMR techniques and includes novel developments in the field such as hyperpolarized NMR, dynamic 13C NMR, automated shimming, and parallel acquisitions. Most of the techniques are described from an educational point of view, yet it still retains the practical aspects appreciated by experimental NMR spectroscopists. In addition, each chapter concludes with a number of exercises designed to review, and often extend, the presented NMR principles and techniques. The third edition of In Vivo NMR Spectroscopy: Principles and Techniques has been updated to include experimental detail on the developing area of hyperpolarization; a description of the semi-LASER sequence, which is now a method of choice; updated chemical shift data, including the addition of 31P data; a troubleshooting section on common problems related to shimming, water suppression, and quantification; recent developments in data acquisition and processing standards; and MatLab scripts on the accompanying website for helping readers calculate radiofrequency pulses. Provide an educational explanation and overview of in vivo NMR, while maintaining the practical aspects appreciated by experimental NMR spectroscopists Features more experimental methodology than the previous edition End-of-chapter exercises that help drive home the principles and techniques and offer a more in-depth exploration of quantitative MR equations Designed to be used in conjunction with a teaching course on the subject In Vivo NMR Spectroscopy: Principles and Techniques, 3rd Edition is aimed at all those involved in fundamental and/or diagnostic in vivo NMR, ranging from people working in dedicated in vivo NMR institutes, to radiologists in hospitals, researchers in high-resolution NMR and MRI, and in areas such as neurology, physiology, chemistry, and medical biology.

Proceedings

Proceedings Book
Author : Indian National Science Academy
Publisher : Unknown
Release : 2003
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

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The Journal of Nuclear Medicine

The Journal of Nuclear Medicine Book
Author : Anonim
Publisher : Unknown
Release : 2009
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download The Journal of Nuclear Medicine book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Applied Science Technology Index

Applied Science   Technology Index Book
Author : Anonim
Publisher : Unknown
Release : 2000
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

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Biomolecular Sensing and Imaging Using Hyperpolarized 129Xe Magnetic Resonance

Biomolecular Sensing and Imaging Using Hyperpolarized 129Xe Magnetic Resonance Book
Author : Thomas J. Lowery
Publisher : Unknown
Release : 2007
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Biomolecular Sensing and Imaging Using Hyperpolarized 129Xe Magnetic Resonance book written by Thomas J. Lowery, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

49th ENC

49th ENC Book
Author : Anonim
Publisher : Unknown
Release : 2008
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

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Cancer Research

Cancer Research Book
Author : Anonim
Publisher : Unknown
Release : 2009-10
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

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Experimental Biology and Medicine

Experimental Biology and Medicine Book
Author : Anonim
Publisher : Unknown
Release : 2009
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

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Encyclopedia of Spectroscopy and Spectrometry I N

Encyclopedia of Spectroscopy and Spectrometry  I N Book
Author : John C. Lindon
Publisher : Unknown
Release : 2000
ISBN : 9780122266829
Language : En, Es, Fr & De

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Book Description :

The Encyclopedia provides coverage of current knowledge in the field of spectroscopy and related areas.

Laser polarized 129Xe Magnetic Resonance Spectroscopy and Imaging

Laser polarized 129Xe Magnetic Resonance Spectroscopy and Imaging Book
Author : Matthew S. Rosen
Publisher : Unknown
Release : 2001
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Laser polarized 129Xe Magnetic Resonance Spectroscopy and Imaging book written by Matthew S. Rosen, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Metabolic Signatures of Prostate Cancer and Renal Cell Carcinoma Using High resolution NMR and Hyperpolarized 13C MRI

Metabolic Signatures of Prostate Cancer and Renal Cell Carcinoma Using High resolution NMR and Hyperpolarized 13C MRI  Book
Author : Jinny Sun
Publisher : Unknown
Release : 2020
ISBN : 9781658492089
Language : En, Es, Fr & De

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Book Description :

Non-invasive techniques to assess metabolic reprogramming during cancer progression can be used to improve therapeutic selection and provide an early assessment of therapeutic response or resistance in individual patients. Prior studies have shown that metabolic reprogramming plays a key role in the development of prostate cancer and renal cell carcinoma (RCC). This dissertation further elucidates the metabolic alterations that occur in treatment-resistant prostate cancer and in patient-derived models of RCC using high-resolution nuclear magnetic resonance (NMR) spectroscopy and hyperpolarized (HP) 13C magnetic resonance imaging (MRI), with the goal of identifying new non-invasive diagnostic imaging tools. Glycolysis, metabolism of pyruvate and glutamate via the tricarboxylic acid (TCA) cycle, glutaminolysis, and glutathione synthesis are upregulated in castration-resistant prostate cancer (CRPC) compared to their androgen-dependent counterparts, using human cell lines as well a treatment-driven transgenic murine model. These metabolic alterations were reversed in castration-resistant murine tumors by treatment with a secondary androgen pathway inhibitor, apalutamide, suggesting that early metabolic responses to treatment can be monitored using non-invasive imaging techniques. Furthermore, treatment-emergent small cell neuroendocrine prostate cancer, a consequence of protracted treatment with primary androgen deprivation therapy and secondary androgen pathway inhibitors, exhibits significantly upregulated glycolysis, TCA cycle metabolism of pyruvate and glutamate, and glutaminolysis, as well as significantly altered redox capacity compared to castration-resistant prostate adenocarcinoma using patient-derived xenograft models. Finally, the metabolic differences associated with the tumor microenvironment were compared between various patient-derived models of RCC, finding that RCC patient-derived xenografts (PDXs) displayed higher redox capacity and were more proliferative than cells and tissue slices derived from the PDXs and maintained ex vivo. The work presented in this dissertation suggests that a combination of HP [1-13C]pyruvate, [2-13C]pyruvate, [5-13C]glutamine, and [1-13C]dehydroascorbate can be used to distinguish advanced prostate cancer and RCC subtypes in future HP 13C MRI of patients for improved treatment selection and monitoring.