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Hyperpolarized Carbon 13 Magnetic Resonance Imaging And Spectroscopy

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Hyperpolarized Carbon 13 Magnetic Resonance Imaging and Spectroscopy

Hyperpolarized Carbon 13 Magnetic Resonance Imaging and Spectroscopy Book
Author : Peder Larson
Publisher : Academic Press
Release : 2021-10-15
ISBN : 9780128222690
Language : En, Es, Fr & De

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Book Description :

MRI with hyperpolarized carbon-13 agents is a powerful emerging imaging modality that can measure real-time metabolism in cells, animals, and humans. It uses endogenous, non-toxic contrast agents that a hyperpolarized, resulting in up to 100,000-fold increases in sensitivity. This technique uses no ionizing radiation, and is being applied in a range of human trials. It's primary use is for metabolic imaging, but it can also measure perfusion, pH, and necrosis. Hyperpolarized Carbon-13 Magnetic Resonance Imaging and Spectroscopy is designed to be a one stop shop for understanding hyperpolarized 13C MRI. This book explains the principles of this imaging modality, the requirements for performing studies, shows how to interpret the results, and gives an overview of current biomedical applications. It is suitable for engineers, scientists and clinicians in radiology and biomedical imaging who want to understand this technology. Presents the physics and hardware of dissolution dynamic nuclear polarization Explains the behaviour of hyperpolarized carbon-13 agents and how to image them Detailed guidance on experimental design and data interpretation Identifies promising and potential applications of hyperpolarized carbon-13 MR

Hyperpolarized Carbon 13 Magnetic Resonance Imaging as a Tool for Assessing Lung Transplantation Outcomes

Hyperpolarized Carbon 13 Magnetic Resonance Imaging as a Tool for Assessing Lung Transplantation Outcomes Book
Author : Sarmad Siddiqui
Publisher : Unknown
Release : 2019
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Lung transplantation is the established treatment for patients with chronic, end-stage lung diseases such as chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF) and cystic fibrosis (CF). However, its utility remains limited by the chronic shortage of donor lungs, limited lung preservation strategies and post-transplant complications leading to graft failure. Although efforts have been made to expand the limited pool of viable donor lungs via novel preservation strategies such as ex vivo lung perfusion (EVLP), our limited understanding of the mechanism and progression of donor lung injury continues to inhibit our ability to fully exploit these advances to improve lung transplant outcomes. Furthermore, the clinical standard for post-transplant assessment is limited to whole lung measurement such as pulmonary functional tests (PFTs) and structural imaging via radiography or HRCT, both of which lack the necessary sensitivity to detect lung rejection early. Given these limitations of currently available pre- and post-transplant lung assessment tools, a novel metabolic biomarker may provide higher sensitivity for determining the viability of donated lungs, as well as for assessing the onset of rejection before permanent structural changes in the lungs become apparent. We proposed that hyperpolarized (HP) [1-13C]pyruvate magnetic resonance imaging (MRI)--which provides real-time metabolic assessment of tissue based on the conversion of [1-13C] pyruvate to [1-13C]lactate via glycolysis, or to 13C bicarbonate via oxidative phosphorylation--may be an effective tool for assessing the health of donated lungs and may also serve as an early biomarker for detecting pulmonary graft dysfunction (PGD)-associated inflammation or acute lung rejection. In a rat model, we demonstrated the feasibility of using HP [1-13C]pyruvate nuclear magnetic resonance (NMR) spectroscopy to assess the viability of ex vivo perfused lungs. We further showed that our technique can be used to measure the improved viability of those lungs after treatment with ascorbic acid. Finally, translating our previously developed technique to in vivo HP [1-13C]pyruvate imaging of an inflamed rat lung, we not only demonstrated its utility for detecting lung transplantation rejection, but found that the HP lactate-to-pyruvate ratio is a better predictor of acute lung rejection in a rat model than computed tomography.

In Vivo NMR Spectroscopy

In Vivo NMR Spectroscopy Book
Author : Robin A. de Graaf
Publisher : John Wiley & Sons
Release : 2019-03-11
ISBN : 1119382548
Language : En, Es, Fr & De

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Book Description :

Presents basic concepts, experimental methodology and data acquisition, and processing standards of in vivo NMR spectroscopy This book covers, in detail, the technical and biophysical aspects of in vivo NMR techniques and includes novel developments in the field such as hyperpolarized NMR, dynamic 13C NMR, automated shimming, and parallel acquisitions. Most of the techniques are described from an educational point of view, yet it still retains the practical aspects appreciated by experimental NMR spectroscopists. In addition, each chapter concludes with a number of exercises designed to review, and often extend, the presented NMR principles and techniques. The third edition of In Vivo NMR Spectroscopy: Principles and Techniques has been updated to include experimental detail on the developing area of hyperpolarization; a description of the semi-LASER sequence, which is now a method of choice; updated chemical shift data, including the addition of 31P data; a troubleshooting section on common problems related to shimming, water suppression, and quantification; recent developments in data acquisition and processing standards; and MatLab scripts on the accompanying website for helping readers calculate radiofrequency pulses. Provide an educational explanation and overview of in vivo NMR, while maintaining the practical aspects appreciated by experimental NMR spectroscopists Features more experimental methodology than the previous edition End-of-chapter exercises that help drive home the principles and techniques and offer a more in-depth exploration of quantitative MR equations Designed to be used in conjunction with a teaching course on the subject In Vivo NMR Spectroscopy: Principles and Techniques, 3rd Edition is aimed at all those involved in fundamental and/or diagnostic in vivo NMR, ranging from people working in dedicated in vivo NMR institutes, to radiologists in hospitals, researchers in high-resolution NMR and MRI, and in areas such as neurology, physiology, chemistry, and medical biology.

Handbook of Magnetic Resonance Spectroscopy In Vivo

Handbook of Magnetic Resonance Spectroscopy In Vivo Book
Author : Paul A. Bottomley,John R. Griffiths
Publisher : John Wiley & Sons
Release : 2016-12-19
ISBN : 1118997662
Language : En, Es, Fr & De

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Book Description :

This handbook covers the entire field of magnetic resonance spectroscopy (MRS), a unique method that allows the non-invasive identification, quantification and spatial mapping of metabolites in living organisms–including animal models and patients. Comprised of three parts: Methodology covers basic MRS theory, methodology for acquiring, quantifying spectra, and spatially localizing spectra, and equipment essentials, as well as vital ancillary issues such as motion suppression and physiological monitoring. Applications focuses on MRS applications, both in animal models of disease and in human studies of normal physiology and disease, including cancer, neurological disease, cardiac and muscle metabolism, and obesity. Reference includes useful appendices and look up tables of relative MRS signal-to-noise ratios, typical tissue concentrations, structures of common metabolites, and useful formulae. About eMagRes Handbooks eMagRes (formerly the Encyclopedia of Magnetic Resonance) publishes a wide range of online articles on all aspects of magnetic resonance in physics, chemistry, biology and medicine. The existence of this large number of articles, written by experts in various fields, is enabling the publication of a series of eMagRes Handbooks on specific areas of NMR and MRI. The chapters of each of these handbooks will comprise a carefully chosen selection of eMagRes articles. In consultation with the eMagRes Editorial Board, the eMagRes Handbooks are coherently planned in advance by specially-selected Editors, and new articles are written to give appropriate complete coverage. The handbooks are intended to be of value and interest to research students, postdoctoral fellows and other researchers learning about the scientific area in question and undertaking relevant experiments, whether in academia or industry. Have the content of this handbook and the complete content of eMagRes at your fingertips! Visit the eMagRes Homepage

Dynamic Hyperpolarized Nuclear Magnetic Resonance

Dynamic Hyperpolarized Nuclear Magnetic Resonance Book
Author : Thomas Jue
Publisher : Springer Nature
Release : 2021-09-20
ISBN : 3030550435
Language : En, Es, Fr & De

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Book Description :

Download Dynamic Hyperpolarized Nuclear Magnetic Resonance book written by Thomas Jue, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Molecular Imaging

Molecular Imaging Book
Author : Brian D. Ross,Sanjiv S. Gambhir
Publisher : Academic Press
Release : 2021-08-09
ISBN : 0128163879
Language : En, Es, Fr & De

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Book Description :

The detection and measurement of the dynamic regulation and interactions of cells and proteins within the living cell are critical to the understanding of cellular biology and pathophysiology. The multidisciplinary field of molecular imaging of living subjects continues to expand with dramatic advances in chemistry, molecular biology, therapeutics, engineering, medical physics and biomedical applications. Molecular Imaging: Principles and Practice, Volumes 1 and 2, Second Edition provides the first point of entry for physicians, scientists, and practitioners. This authoritative reference book provides a comprehensible overview along with in-depth presentation of molecular imaging concepts, technologies and applications making it the foremost source for both established and new investigators, collaborators, students and anyone interested in this exciting and important field. The most authoritative and comprehensive resource available in the molecular-imaging field, written by over 170 of the leading scientists from around the world who have evaluated and summarized the most important methods, principles, technologies and data Concepts illustrated with over 600 color figures and molecular-imaging examples Chapters/topics include, artificial intelligence and machine learning, use of online social media, virtual and augmented reality, optogenetics, FDA regulatory process of imaging agents and devices, emerging instrumentation, MR elastography, MR fingerprinting, operational radiation safety, multiscale imaging and uses in drug development This edition is packed with innovative science, including theranostics, light sheet fluorescence microscopy, (LSFM), mass spectrometry imaging, combining in vitro and in vivo diagnostics, Raman imaging, along with molecular and functional imaging applications Valuable applications of molecular imaging in pediatrics, oncology, autoimmune, cardiovascular and CNS diseases are also presented This resource helps integrate diverse multidisciplinary concepts associated with molecular imaging to provide readers with an improved understanding of current and future applications

Functional Imaging in Oncology

Functional Imaging in Oncology Book
Author : Antonio Luna,Joan C. Vilanova,L. Celso Hygino da Cruz Jr.,Santiago E. Rossi
Publisher : Springer Science & Business Media
Release : 2013-12-11
ISBN : 364240412X
Language : En, Es, Fr & De

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Book Description :

In the new era of functional and molecular imaging, both currently available imaging biomarkers and biomarkers under development are expected to lead to major changes in the management of oncological patients. This well-illustrated two-volume book is a practical manual on the various imaging techniques capable of delivering functional information on cancer, including preclinical and clinical imaging techniques, based on US, CT, MRI, PET and hybrid modalities. This first volume explains the biophysical basis for these functional imaging techniques and describes the techniques themselves. Detailed information is provided on the imaging of cancer hallmarks, including angiogenesis, tumor metabolism, and hypoxia. The techniques and their roles are then discussed individually, covering the full range of modalities in clinical use as well as new molecular and functional techniques. The value of a multiparametric approach is also carefully considered.

Magnetic Resonance Sensors

Magnetic Resonance Sensors Book
Author : Robert H. Morris,Michael I. Newton
Publisher : MDPI
Release : 2018-10-04
ISBN : 3906980987
Language : En, Es, Fr & De

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Book Description :

This book is a printed edition of the Special Issue "Magnetic Resonance Sensors" that was published in Sensors

Exploring Cancer Metabolic Reprogramming through Molecular Imaging

Exploring Cancer Metabolic Reprogramming through Molecular Imaging Book
Author : Franca Podo,Zaver M. Bhujwalla,Egidio Iorio
Publisher : Frontiers Media SA
Release : 2017-07-27
ISBN : 2889452344
Language : En, Es, Fr & De

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Book Description :

The inclusion of oncogene-driven reprogramming of energy metabolism within the list of cancer hallmarks (Hanahan and Weinberg, Cell 2000, 2011) has provided major impetus to further investigate the existence of a much wider metabolic rewiring in cancer cells, which not only includes deregulated cellular bioenergetics, but also encompasses multiple links with a more comprehensive network of altered biochemical pathways. This network is currently held responsible for redirecting carbon and phosphorus fluxes through the biosynthesis of nucleotides, amino acids, lipids and phospholipids and for the production of second messengers essential to cancer cells growth, survival and invasiveness in the hostile tumor environment. The capability to develop such a concerted rewiring of biochemical pathways is a versatile tool adopted by cancer cells to counteract the host defense and eventually resist the attack of anticancer treatments. Integrated efforts elucidating key mechanisms underlying this complex cancer metabolic reprogramming have led to the identification of new signatures of malignancy that are providing a strong foundation for improving cancer diagnosis and monitoring tumor response to therapy using appropriate molecular imaging approaches. In particular, the recent evolution of positron emission tomography (PET), magnetic resonance spectroscopy (MRS), spectroscopic imaging (MRSI), functional MR imaging (fMRI) and optical imaging technologies, combined with complementary cellular imaging approaches, have created new ways to explore and monitor the effects of metabolic reprogramming in cancer at clinical and preclinical levels. Thus, the progress of high-tech engineering and molecular imaging technologies, combined with new generation genomic, proteomic and phosphoproteomic methods, can significantly improve the clinical effectiveness of image-based interventions in cancer and provide novel insights to design and validate new targeted therapies. The Frontiers in Oncology Research Topic “Exploring Cancer Metabolic Reprogramming Through Molecular Imaging” focusses on current achievements, challenges and needs in the application of molecular imaging methods to explore cancer metabolic reprogramming, and evaluate its potential impact on clinical decisions and patient outcome. A series of reviews and perspective articles, along with original research contributions on humans and on preclinical models have been concertedly included in the Topic to build an open forum on perspectives, present needs and future challenges of this cutting-edge research area.

Quantitative MRI in Cancer

Quantitative MRI in Cancer Book
Author : Thomas E. Yankeelov,David R. Pickens,Ronald R. Price
Publisher : Taylor & Francis
Release : 2011-09-13
ISBN : 1439820589
Language : En, Es, Fr & De

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Book Description :

Propelling quantitative MRI techniques from bench to bedside, Quantitative MRI in Cancer presents a range of quantitative MRI methods for assessing tumor biology. It includes biophysical and theoretical explanations of the most relevant MRI techniques as well as examples of these techniques in cancer applications. The introductory part of the book covers basic cancer biology, theoretical aspects of NMR/MRI physics, and the hardware required to form MR images. Forming the core of the book, the next three parts illustrate how to characterize tissue properties with endogenous and exogenous contrast mechanisms and discuss common image processing techniques relevant for cancer. The final part explores emerging areas of MR cancer characterization, including radiation therapy planning, cellular and molecular imaging, pH imaging, and hyperpolarized MR. Each of the post-introductory chapters describes the salient qualitative and quantitative aspects of the techniques before proceeding to preclinical and clinical applications. Each chapter also contains references for further study. Leading the way toward more personalized medicine, this text brings together existing and emerging quantitative MRI techniques for assessing cancer. It provides a self-contained overview of the theoretical and experimental essentials and state of the art in cancer MRI.

Chemical Physics and Applications of Dynamic Nuclear Polarization enhanced Nuclear Magnetic Resonance

Chemical Physics and Applications of Dynamic Nuclear Polarization enhanced Nuclear Magnetic Resonance Book
Author : Christopher Parish
Publisher : Unknown
Release : 2019
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Nuclear magnetic resonance (NMR) spectroscopy of nuclei with low magnetic moments such as 13C spins can be quite challenging and time-consuming. Dynamic nuclear polarization (DNP) via the dissolution method greatly alleviates this sensitivity problem by enhancing the NMR signals of these insensitive nuclei by several thousand-fold. Dissolution DNP thus allows 13C NMR tracking of cellular metabolism in living cells in real-time with superb sensitivity and high specificity. Herein, the bulk of my PhD dissertation work has been devoted to the elucidation and optimization of chemical physics of DNP technology in pursuit of attaining the highest NMR signal enhancements. One finding highlighted in this dissertation is the confirmation that the solidstate 13C DNP efficiency is affected by the isotopic location of the 13C label within the target molecule. Such can be explained via the thermal mixing model of DNP. Another major work in this dissertation is the investigation of the effects of 2H enrichment of the glassing solvents on the solid-state 13C spin-lattice T1 relaxation times of hyperpolarized 13C acetate. It is reported herein that glassing solvent deuteration elongates the 13C T1 relaxation times significantly, indicative of reduced intermolecular dipolar interaction of 13C spins with 2H spins compared to coupling with 1H spins. Next, this dissertation also encompasses two studies regarding the effect upon DNP of doping samples with mixtures of two different free radicals as opposed to doping them with one type of free radical. In one of the two studies, it was determined that a mixture of the wide EPR width 4-oxo-TEMPO and narrow EPR width trityl OX063 yields interesting 13C DNP results. There appears to be competing effects when the microwave irradiation frequency was set to the negative polarization peak of trityl OX063 which coincides with the positive polarization peak of 4-oxo-TEMPO. On the other hand, a mixture of both narrow EPR widths trityl and BDPA free radicals yields an additive effect. Finally, this dissertation also details the use of 13C NMR in the characterization of 13C-labelled amino acids and their application in investigating cancer cell metabolism. 13C-labeled amino acids are potential hyperpolarized 13C NMR spectroscopy and imaging (MRI) metabolic probes for cancer because a number of metabolic pathways that involve these biomolecules are abnormal in tumors. For instance, the enzyme branched chain amino acid transferase (BCAT), which catalyzes the conversion of branched chain amino acids (BCAA) to their ketoacid counterparts or vice versa, is overexpressed in several cancers. In this project, [1- 13C] L-leucine and [1- 13C] alpha-ketoisocaproate (KIC) were used to study the aberrant BCAT metabolic activity in glioblastoma. SfXL glioblastoma cells appear to preferentially convert 13CKIC to 13C leucine rather than vice versa. Western blot experiments confirmed that BCAT expression is higher in SfXL cells than in normal astrocytes. Overall, this dissertation details the chemical tuning methods in DNP that I have unraveled in pursuit of attaining the highest 13C NMR signal enhancements. These optimized DNP signals are crucial to the success of in vivo NMR or MRI studies, particularly in probing the hyperactive metabolism of cancer.

Functional and Molecular Imaging in Oncology An Issue of Magnetic Resonance Imaging Clinics of North America

Functional and Molecular Imaging in Oncology  An Issue of Magnetic Resonance Imaging Clinics of North America  Book
Author : Antonio Luna
Publisher : Elsevier Health Sciences
Release : 2016-01-19
ISBN : 0323416993
Language : En, Es, Fr & De

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Book Description :

This issue of MRI Clinics of North America focuses on Functional MRI in Oncology. Articles will include: Functional MRI techniques in oncology in the era of personalized medicine, MRI biomarkers and surrogate endpoints in oncology clinical trials, Therapy monitoring with functional MRI, Multiparametric MRI in the assessment of brain tumors, Multiparametric MRI of breast cancer, Functional MRI in chest malignancies, Multiparametric MRI in abdominal malignancies, Assessment of musculoskeletal malignancies with functional MRI, Evaluation of head and neck tumors with functional MRI, Role of multiparametric MRI in malignancies of the urogenital tract, Diffusion-weighted imaging in oncology, Functional MRI in gynecologic cancer, Assessment of angiogenesis with MRI: DCE-MRI and beyond, Imaging of tumor metabolism: MR spectroscopy, and more!

Brain Tumor Imaging

Brain Tumor Imaging Book
Author : Elke Hattingen,Ulrich Pilatus
Publisher : Springer
Release : 2015-09-02
ISBN : 3642450407
Language : En, Es, Fr & De

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Book Description :

This book describes the basics, the challenges and the limitations of state of the art brain tumor imaging and examines in detail its impact on diagnosis and treatment monitoring. It opens with an introduction to the clinically relevant physical principles of brain imaging. Since MR methodology plays a crucial role in brain imaging, the fundamental aspects of MR spectroscopy, MR perfusion and diffusion-weighted MR methods are described, focusing on the specific demands of brain tumor imaging. The potential and the limits of new imaging methodology are carefully addressed and compared to conventional MR imaging. In the main part of the book, the most important imaging criteria for the differential diagnosis of solid and necrotic brain tumors are delineated and illustrated in examples. A closing section is devoted to the use of MR methods for the monitoring of brain tumor therapy. The book is intended for radiologists, neurologists, neurosurgeons, oncologists and other scientists in the biomedical field with an interest in neuro-oncology.

Assessment of Tumor Metabolism Using Hyperpolarized 13C Magnetic Resonance Spectroscopy

Assessment of Tumor Metabolism Using Hyperpolarized 13C Magnetic Resonance Spectroscopy Book
Author : Jae Mo Park
Publisher : Unknown
Release : 2012
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Unlike normal tissues, solid tumors have a metabolic phenotype that favors energy-inefficient glycolysis rather than more efficient, but oxygen consuming, oxidative phosphorylation, even when oxygen levels are adequate. This metabolic shift towards glycolysis, discovered by Warburg in 1924, has been studied for more than 80 years, but the mechanism of the phenomena is still unclear due to lack of tools for in vivo investigation. Dynamic nuclear polarization in combination with the recent development of a dissolution process that retains the increased polarization into the liquid state opened new possibilities for the real-time investigation of in vivo metabolism using C13 magnetic resonance spectroscopy. In particular, hyperpolarized [1-13C]pyruvate, a substrate occupying a key nodal point in the glucose metabolic pathway, has been successfully demonstrated as a neoplasm biomarker via elevated lactate labeling in tumors. However, additional downstream products of pyruvate metabolism, such as that occur in mitochondria of brain tumor, have been veiled due to low signal-to-noise ratios. The first part of the thesis is on the quantitative assessment of mitochondrial function in normal rat brain and glioma by detecting 13C-bicarbonate following the bolus injection of [1-13C]pyruvate. The feasibility of quantitatively detecting 13C-bicarbonate in tumor-bearing rat brain is demonstrated for the first time. The optimized protocol for chemical shift imaging and high concentration of hyperpolarized [1-13C]pyruvate were used to improve measurements of lactate and bicarbonate in C6 glioma-transplanted rat brains. Moreover, the immediate response to dichloroacetate treatment, which upregulates pyruvate flux to acetyl-CoA, is also presented. It is demonstrated that the simultaneous detection of lactate and bicarbonate provides a tool for a more comprehensive analysis of glioma metabolism and the assessment of metabolic agents as anti-cancer drugs. In the second part of the thesis, further investigation on mitochondrial metabolism, including tricarboxylic acid cycle, is presented by acquiring single-time point chemical shift imaging data from rat brain in vivo after administration of highly concentrated [2-13C]pyruvate. A C13 surface coil optimized for rat brain was built to increase sensitivity of signal detection. [5-13C]glutamate, [1-13C]acetyl carnitine, and [1-13C]citrate were detected besides [2-13C]pyruvate and [2-13C]lactate, for the first time in brain. Change of the tricarboxylic acid cycle activity in brain was also investigated by infusing dichloroacetate. The increase of [5-13C]glutamate was detected primarily from brain, whereas [1-13C]acetyl carnitine was increased in peripheral tissues after the infusion of dichloroacetate. The third part focuses on dynamic measurements of hyperpolarized substrates to obtain exchange rates in addition to concentrations, and proposes the apparent conversion rate as a new metric to detect glioma by comparing the conversion rates in glioma, normal appearing brain, and basilar vasculature in female Sprague-Dawley rats with C6 glioma cells implanted. Whereas single-time point measurements give a snapshot image of tissue metabolism, the estimated apparent rate constant yielded a better differentiation between the tissue types than the lactate-to-pyruvate ratio, which has been the most common metric used to date. This study demonstrates the feasibility of quantitatively detecting C13-labeled bicarbonate and glutamate in vivo, permitting the assessment of dichloroacetate-modulate changes in pyruvate dehydrogenase flux in both normal rat brain and glioma. The simultaneous detection of both lactate dehydrogenase and pyruvate dehydrogenase activities will likely improve our ability to both assess and monitor metabolic therapies of brain and other cancers by providing non-invasive in vivo measures of glycolysis and oxidative phosphorylation.

The EACVI Textbook of Cardiovascular Magnetic Resonance

The EACVI Textbook of Cardiovascular Magnetic Resonance Book
Author : Victor Ferrari
Publisher : Oxford University Press
Release : 2018-09-13
ISBN : 0191085057
Language : En, Es, Fr & De

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Book Description :

This highly comprehensive and informed textbook has been prepared by the Cardiovascular Magnetic Resonance section of the European Society of Cardiology association on imaging, the EACVI. The EACVI Textbook of Cardiovascular Magnetic Resonance is the authority on the subject. The textbook is aligned with ESC Core Curriculum and EACVI Core Syllabus for CMR. It is a practical resource and provides a disease orientated outlook on the subject. Structured with thirteen clear and detailed sections, ranging from Physics to Methodology, and featuring specific sections on ischemic heart disease, myocardial disease, pericardial disease, and congenital heart disease and adult congenital heart disease, The EACVI Textbook of Cardiovascular Magnetic Resonance provides extensive knowledge across the entire subject area in CMR. Beautifully illustrated and physical principles enriched with schematic animations, the textbook is advanced further with key video content based on clinical cases. Written by leading experts in the field from across the world, the textbook aims to summarise the existing research and clinical evidence for the various CMR indications and provide an invaluable resource for cardiologists and radiologists across the board. The textbook is ideal for cardiologists and radiologists new to the field of Cardiovascular Magnetic Resonance, those preparing for ESC certification in CMR, and those established in the field wishing to gain a deep understanding of CMR. Online access to the digital version is included with purchase of the print book, with accompanying videos referenced within the text available on Oxford Medicine Online.

Handbook of Magnetic Resonance Spectroscopy In Vivo

Handbook of Magnetic Resonance Spectroscopy In Vivo Book
Author : Paul A. Bottomley,John R. Griffiths
Publisher : John Wiley & Sons
Release : 2016-10-19
ISBN : 1118997697
Language : En, Es, Fr & De

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Book Description :

This handbook covers the entire field of magnetic resonance spectroscopy (MRS), a unique method that allows the non-invasive identification, quantification and spatial mapping of metabolites in living organisms–including animal models and patients. Comprised of three parts: Methodology covers basic MRS theory, methodology for acquiring, quantifying spectra, and spatially localizing spectra, and equipment essentials, as well as vital ancillary issues such as motion suppression and physiological monitoring. Applications focuses on MRS applications, both in animal models of disease and in human studies of normal physiology and disease, including cancer, neurological disease, cardiac and muscle metabolism, and obesity. Reference includes useful appendices and look up tables of relative MRS signal-to-noise ratios, typical tissue concentrations, structures of common metabolites, and useful formulae. About eMagRes Handbooks eMagRes (formerly the Encyclopedia of Magnetic Resonance) publishes a wide range of online articles on all aspects of magnetic resonance in physics, chemistry, biology and medicine. The existence of this large number of articles, written by experts in various fields, is enabling the publication of a series of eMagRes Handbooks on specific areas of NMR and MRI. The chapters of each of these handbooks will comprise a carefully chosen selection of eMagRes articles. In consultation with the eMagRes Editorial Board, the eMagRes Handbooks are coherently planned in advance by specially-selected Editors, and new articles are written to give appropriate complete coverage. The handbooks are intended to be of value and interest to research students, postdoctoral fellows and other researchers learning about the scientific area in question and undertaking relevant experiments, whether in academia or industry. Have the content of this handbook and the complete content of eMagRes at your fingertips! Visit the eMagRes Homepage

Imaging in Gynecologic Oncology An Issue of PET Clinics E Book

Imaging in Gynecologic Oncology  An Issue of PET Clinics  E Book Book
Author : Drew A. Torigian,Domenico Rubello
Publisher : Elsevier Health Sciences
Release : 2018-03-07
ISBN : 0323583199
Language : En, Es, Fr & De

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Book Description :

This issue of PET Clinics focuses on Imaging in Gynecologic Oncology, and is edited by Drs. Drew Torigian and Domenico Rubello. Articles will include: The role of CT and MRI in gynecologic oncology; The utility of ultrasonography in gynecologic oncology; FDG-PET assessment of cervical cancer; FDG-PET assessment of ovarian cancer; FDG-PET assessment of other gynecologic cancers; The role of PET imaging in gynecologic radiation oncology; The utility of non-FDG PET in gynecologic oncology; Normal variants and pitfalls encountered in PET assessment of gynecologic malignancies; The role and future of quantitative imaging assessment in gynecologic oncology; Emerging molecular imaging techniques in gynecologic oncology; and more!

Magnetic Resonance Imaging of a Natural Killer Cell Therapy in a Mouse Model of Prostate Cancer

Magnetic Resonance Imaging of a Natural Killer Cell Therapy in a Mouse Model of Prostate Cancer Book
Author : Christiane L. Mallett
Publisher : Unknown
Release : 2013
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

This thesis uses magnetic resonance imaging (MRI) techniques to study natural killer (NK) cell therapy in a nude mouse model of prostate cancer. Cellular MRI, anatomical MRI and hyperpolarized 13C spectroscopy were used to study various aspects of the model. Methods: The cells used were KHYG-1 NK cells and PC-3M prostate cancer cells. Imaging was performed on a clinical 3T GE MR 750 scanner, using a high-performance gradient insert for acquisition with the balanced steady state free precession (bSSFP) sequence, and using the built-in gradients for 13C pyruvate spectroscopy. Pyruvate was hyperpolarized by dynamic nuclear polarization. Results: KHYG-1 were toxic to PC-3M in vitro and were successfully labeled with MoldayRhodamine, a superparamagnetic iron oxide nanoparticle (SPIO). A subcutaneous PC-3M tumour model was used to investigate tracking of KHYG-1 in vivo using the bSSFP sequence. Four days after administration, KHYG-1 accumulation in the tumours was detected by histology but not by MRI, although labeled KHYG-1 at high density were visible in MR images. The bSSFP sequence was then optimized for imaging the mouse prostate and the whole mouse body. Tumour development in an orthotopic prostate cancer model was characterized by MRI and histology for tumour growth, metastasis and tumour metabolism. Tumours were visible by MRI day 9 after injection. Using histology, metastasis was detected in the lymph nodes and spleen of the mice. Necrotic regions in the tumours were detected on day 22 by both anatomical imaging and pyruvate spectroscopy and were confirmed by histology. Conclusions: KHYG-1 cell therapy shows promise as a treatment of prostate cancer. A mouse model that developed lymph node metastases was characterized. Based on the accumulation of KHYG-1 in SC tumours 4 days after administration, and the consistent presence of MRI-visible tumours on day 9-13, a treatment time point of 9-13 days is proposed for future NK cell tracking experiments.

Molecular Imaging with Reporter Genes

Molecular Imaging with Reporter Genes Book
Author : Sanjiv Sam Gambhir,Shahriar S. Yaghoubi
Publisher : Cambridge University Press
Release : 2010-05-31
ISBN : 1139489526
Language : En, Es, Fr & De

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Book Description :

Reporter genes have been used for several decades to study regulation of gene expression in vivo. However, it was little more than a decade ago that a new class of reporter genes was developed for imaging molecular events within living subjects. By following the interactions of protein molecules, researchers can resolve the complex chemical pathways that living cells utilise. This book focuses on this group of imaging reporter genes, starting with detailed descriptions of all reporter genes from different imaging modalities, including optical, MRI, and radionuclide-based imaging. Key scientists in the field explain how to enhance reporter gene imaging utility through instrumentation and the various applications of this technology. This is the first comprehensive book on all aspects of reporter gene imaging, detailing what is known in the field and future goals for research. Investigators in biomedical sciences, physicians, and the biotechnology and pharmaceutical industries will benefit from topics covered.

Advanced Cardiac Imaging

Advanced Cardiac Imaging Book
Author : Koen Nieman,Oliver Gaemperli,Patrizio Lancellotti,Sven Plein
Publisher : Elsevier
Release : 2015-07-16
ISBN : 1782422943
Language : En, Es, Fr & De

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Book Description :

Advances in Cardiac Imaging presents the latest information on heart disease and heart failure, major causes of death among western populations. In addition, the text explores the financial burden to public healthcare trusts and the vast amount of research and funding being channeled into programs not only to prevent such diseases, but also to diagnose them in early stages. This book provides readers with a thorough overview of many advances in cardiac imaging. Chapters include technological developments in cardiac imaging and imaging applications in a clinical setting with regard to detecting various types of heart disease. Presents a thorough overview of cardiac imaging technology Addresses specific applications for a number of cardiac diseases and how they can improve diagnoses and treatment protocols Includes technological developments in cardiac imaging and imaging applications in a clinical setting