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Huntington Disease

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Huntington s Disease

Huntington s Disease Book
Author : Oliver Quarrell,Oliver (Consultant in Clinical Genetics Quarrell, Sheffield Children's Hospital Sheffield UK)
Publisher : Facts Series
Release : 2020-11
ISBN : 0198844387
Language : En, Es, Fr & De

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Book Description :

Huntington's disease (HD) is a genetically inherited condition resulting in severe nerve-cell damage in the brain. Written for patients and their families, this book explains the features of HD, the role of genetics, and advice on managing symptoms.

Huntington s Disease

Huntington s Disease Book
Author : Gillian Bates,Sarah Tabrizi,Lesley Jones
Publisher : Oxford University Press (UK)
Release : 2014
ISBN : 0199929149
Language : En, Es, Fr & De

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Book Description :

Preceded by Huntington's disease / [edited by] Gillian Bates, Peter S. Harper, Lesley Jones. 3rd ed. 2002.

Huntington s Disease

Huntington s Disease Book
Author : David M. Lawrence
Publisher : Infobase Publishing
Release : 2009
ISBN : 079109586X
Language : En, Es, Fr & De

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Book Description :

Describes the disease, including its origins, symptoms, treatments, and genetic research towards finding a cure.

Huntington s Disease

Huntington s Disease Book
Author : Thomas J. Visser
Publisher : Nova Biomedical
Release : 2010
ISBN : 9781617287497
Language : En, Es, Fr & De

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Book Description :

Huntington's disease, chorea or disorder (HD) is an incurable neurodegenerative genetic disorder, which affects muscle co-ordination and some cognitive functions, typically becoming noticeable in middle age. It is the most common genetic cause of abnormal involuntary writhing movements called chorea and is much more common in people of Western European descent than in those from Asia or Africa. The disease is caused by a dominant mutation on either of the two copies of a gene called Huntington. This book gathers and presents current research in the study of Huntington's Disease including the outlining effects of mutant htt in the nucleus and cytoplasm and the role of cell-cell interactions in Huntington's Disease pathology, as well as a review of the role of Huntington (HTT) interacting proteins.

Huntington s Disease

Huntington s Disease Book
Author : Oliver W J Quarrell
Publisher : OUP Oxford
Release : 2008-02-28
ISBN : 0191607371
Language : En, Es, Fr & De

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Book Description :

Huntington's disease is a genetically inherited condition which results in severe nerve-cell damage in the brain. The hereditary and debilitative nature of the disease means that many people are involved either directly or indirectly by this condition. The recent identification of the faulty gene involved has made the diagnosis of this condition simpler. The majority of people develop the disease between the ages of 35 and 55 years, so for those aware of their genetic risk there are dilemmas to consider - should you have a test to see if you have the gene? Should you start a family? The new edition of this successful book specifically designed for families of patients with Huntington's disease has been expanded to include a number of important new developments in research and clinical practice that have occurred in the field in recent years. While there are no drugs currently available that slow down or reverse the neurodegenerative process in Huntington's Disease, there is growing data on the use of existing treatments to manage movement disorder, irritability and depression associated with the condition, which are covered here. This edition also includes completely new chapters covering juvenile Huntington's disease and late-stage Huntington's disease, and a fully updated Appendix of relevant patients' organizations.

Huntington s Disease

Huntington   s Disease Book
Author : Sophie V. Precious,Anne E. Rosser,Stephen B. Dunnett
Publisher : Humana
Release : 2019-06-15
ISBN : 9781493992966
Language : En, Es, Fr & De

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Book Description :

This detailed book provides a laboratory manual and guidebook for the selection, implementation, and interpretation of a wide range of techniques in contemporary use in leading laboratories engaged in Huntington’s disease (HD) research worldwide. Only by understanding the pathology and pathogenic process at the fundamental molecular and cellular level can the research community expect to be able to slow or halt the disease process, repair the damage, and develop novel effective therapies to treat the symptoms of this condition, thus this volume collects the practical knowledge of its authors. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and invaluable, Huntington’s Disease aims to help scientists to significantly extend the breadth and quality of research in laboratories dedicated to mastering and controlling this devastating human condition.

Juvenile Huntington s Disease

Juvenile Huntington s Disease Book
Author : Oliver W.J. Quarrell,Helen M. Brewer,Ferdinando Squitieri
Publisher : Oxford University Press
Release : 2009-01-08
ISBN : 0199236127
Language : En, Es, Fr & De

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Book Description :

"Edited by members of the European Huntington's Disease Network (EHDN) working party, this book forms the first comprehensive text focusing specifically on juvenile Huntington's disease (JHD). The book includes chapters on the genetic, pathological, and molecular mechanisms of JHD, the current therapies available for treating the condition, as well as the challenges in assessing patients with JHD. This book will serve as a reference for neurologists, movement disorders specialists, medical geneticists, academic/research scientists, and other healthcare professionals." --Book Jacket.

Huntington s Disease

Huntington s Disease Book
Author : Anonim
Publisher : Unknown
Release : 1985
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Huntington s Disease book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Neurobiology of Huntington s Disease

Neurobiology of Huntington   s Disease Book
Author : Donald C. Lo,Robert E. Hughes
Publisher : CRC Press
Release : 2010-07-02
ISBN : 1420008250
Language : En, Es, Fr & De

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Book Description :

In 1993, the genetic mutation responsible for Huntington’s disease (HD) was identified. Considered a milestone in human genomics, this discovery has led to nearly two decades of remarkable progress that has greatly increased our knowledge of HD, and documented an unexpectedly large and diverse range of biochemical and genetic perturbations that seem to result directly from the expression of the mutant huntingtin gene. Neurobiology of Huntington’s Disease: Applications to Drug Discovery presents a thorough review of the issues surrounding drug discovery and development for the treatment of this paradigmatic neurodegenerative disease. Drawing on the expertise of key researchers in the field, the book discusses the basic neurobiology of Huntington’s disease and how its monogenic nature confers enormous practical advantages for translational research, including the creation of robust experimental tools, models, and assays to facilitate discovery and validation of molecular targets and drug candidates for HD. Written to support future basic research as well as drug development efforts, this volume: Covers the latest research approaches in genetics, genomics, and proteomics, including high-throughput and high-content screening Highlights advances in the discovery and development of new drug therapies for neurodegenerative disorders Examines the practical realities of preclinical testing, clinical testing strategies, and, ultimately, clinical usage While the development of effective drug treatments for Huntington's disease continues to be tremendously challenging, a highly interactive and cooperative community of researchers and clinical investigators now brings us to the threshold of potential breakthroughs in the quest for therapeutic agents. The impressive array of drug discovery resources outlined in the text holds much promise for treating this devastating disease, providing hope to long-suffering Huntington’s disease patients and their families.

Huntington s Disease

Huntington s Disease Book
Author : Thomas Newell Chase,Nancy S. Wexler,André Barbeau
Publisher : Unknown
Release : 1979
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Huntington s Disease book written by Thomas Newell Chase,Nancy S. Wexler,André Barbeau, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Huntington s Disease

Huntington s Disease Book
Author : Susan E. Folstein
Publisher : Unknown
Release : 1989
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

A study of current knowledge of clinical care and research about HD. Folstein (psychiatry, Johns Hopkins Univ. School of Medicine) was the clinical director of the Baltimore Huntingtons Disease Project of Johns Hopkins and presents the practical results of that work. Annotation copyrighted by Book News, Inc., Portland, OR

Huntington s Disease

Huntington s Disease Book
Author : Clay Farris Naff
Publisher : Greenhaven Publishing LLC
Release : 2012-06-12
ISBN : 0737757752
Language : En, Es, Fr & De

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Book Description :

Huntington's Disease causes degeneration of brain cells, in motor control regions of the brain, as well as other areas. Symptoms get progressively worse, and include uncontrolled movements, abnormal body postures, and changes in emotion, behavior, judgment, and cognition. People with HD also develop impaired coordination, slurred speech, and difficulty feeding and swallowing. Provide your readers with essential information on HD. This book also serves as a historical survey, by providing information on the controversies surrounding its causes. Compelling first-person narratives by people coping with Huntington's Disease give readers a first-hand experience. Patients, family members, or caregivers explain the condition from their own experience. The symptoms, causes, treatments, and potential cures are explained in detail. Essential to anyone trying to learn about diseases and conditions, the alternative treatments are explored. Student researchers and readers will find this book easily accessible through its careful and conscientious editing and a thorough introduction to each essay.

Huntington s Chorea

Huntington   s Chorea Book
Author : M.R. Hayden
Publisher : Springer Science & Business Media
Release : 2012-12-06
ISBN : 144711308X
Language : En, Es, Fr & De

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Book Description :

Download Huntington s Chorea book written by M.R. Hayden, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Behavioral Neurobiology of Huntington s Disease and Parkinson s Disease

Behavioral Neurobiology of Huntington s Disease and Parkinson s Disease Book
Author : Hoa Huu Phuc Nguyen,M. Angela Cenci
Publisher : Springer
Release : 2015-05-23
ISBN : 366246344X
Language : En, Es, Fr & De

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Book Description :

Motor dysfunction and cognitive impairment are major symptoms in both Huntington’s Disease (HD) and Parkinson’s Disease (PD). A breakthrough in HD research was the identification of the gene that causes this devastating monogenetic illness. Similarly, several genes were found to cause familial forms of PD. With their identification, a plethora of genetic animal models has been generated and has revolutionized the understanding of the pathobiology and pathophysiology of these disorders. The models allow us to study the earliest manifestations of the diseases behaviorally and neuropathologically and help us understand how they progress over time. Additionally, neurotoxic animal models are still of high interest to the PD field, as they are being used to study e.g. mitochondrial dysfunction in PD. This book focuses on animal models of both diseases and how they have helped and will continue to help understand the behavioral neurobiology in these disorders.

Report

Report Book
Author : United States. Commission for the Control of Huntington's Disease and Its Consequences
Publisher : Unknown
Release : 1978
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Report book written by United States. Commission for the Control of Huntington's Disease and Its Consequences, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Huntington s Disease

Huntington s Disease Book
Author : John Hewitt
Publisher : CreateSpace
Release : 2011-04-08
ISBN : 9781453895610
Language : En, Es, Fr & De

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Book Description :

Huntington's disease, which is also known as Huntington's chorea, is a progressive genetic autosomal disorder of the central nervous system that is caused by the degeneration and loss of brain cells. If you or a loved one is affected by this devastating disease, this information packed book will help you make the best treatment choice for the condition.

Brain Stimulation

Brain Stimulation Book
Author : Alfredo Berardelli,Antonio Suppa
Publisher : Elsevier Inc. Chapters
Release : 2013-11-11
ISBN : 0128080507
Language : En, Es, Fr & De

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Book Description :

Several important advances in the pathophysiology of Huntington’s disease (HD) have been achieved by means of neurophysiological techniques designed to investigate the excitability and plasticity of brainstem and cortical circuits in patients with the condition. Studies designed to investigate brainstem reflexes, with paired-pulse and repetitive stimulation of the supraorbital nerve (blink reflex), have demonstrated abnormal excitability and plasticity of brainstem interneurons. In addition, several authors have tested the excitability of the primary motor cortex (M1) with the transcranial magnetic stimulation (TMS) technique and reported abnormal excitability of inhibitory intracortical circuits (cortical silent period, short afferent inhibition). Studies investigating plasticity processes by means of repetitive TMS (rTMS) protocols have demonstrated altered short-term as well as long-term M1 plasticity. Abnormal cortical excitability and plasticity can be present in the early phase of HD and in asymptomatic HD carriers. Evidence from a single study of small cohorts of patients with HD supports the therapeutic application of rTMS for symptomatic improvement of chorea in HD.

In Between Years Life After a Positive Huntington s Disease Test

In Between Years  Life After a Positive Huntington s Disease Test Book
Author : Steven Beatty
Publisher : Library and Archives Canada
Release : 2018-04-14
ISBN : 9781775317807
Language : En, Es, Fr & De

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Book Description :

All proceeds from the sale of this book are going to the Huntington Society of Canada for research and family support services! ---- This book is for those of us going through the "in-between years": the years following our HD genetic testing, but before the symptoms of the illness have begun to take hold. The years when we may struggle with this look into the crystal ball we've been given, for whatever reasons are personal to us. The years when we symptom-hunt and worry about every forgotten purse and each trip and stumble. The years when we watch and care for other Huntington's disease affected loved ones and wonder, how long until it's our turn. ---- Excerpt from the book: "It's not the result we were hoping for." Those eight little words echoed in my head like a Mack Truck rolling through a tunnel. A Mack Truck in the form of a telephone call from a Genetic Counsellor at my local hospital. "What, me?", was my gasped response. "Yes," she replied, "I'm sorry." I sat there in total stunned silence and started to think about all the consequences related to what she had just told me. What this news would mean for my family and me, possibly for generations to come. That was the moment my life completely changed. Changed in pretty much almost every conceivable way. How I looked to the future. How I reflected on the past. How I coped with the present. It changed what I found to be important and what I saw not even to be worth my time. It was the day I found out I was positive for the gene mutation that's responsible for Huntington's disease. The disease that I've heard some resources refer to as "one of the worst diseases you can get" and "it's like having Alzheimer's, ALS and Parkinson's disease all at the same time!" Where was I to go from there? What was I supposed to do? How could I cope with the knowledge that, unless a sufficient treatment came along soon, this disease was going to kill me in the not too distant future? I had no idea what to do next, and I felt utterly alone. ---- Chapters in this book include: 1. Steve's Huntington's Disease Story 2. What Is Huntington's Disease? 3. What Does My CAG Number Tell Me? 4. Becoming Involved with Huntington's Disease Associations 5. Your Health Care Team 6. Participating in Research 7. Symptom Seeking 8. Fear 9. When Do I Tell People About My Huntington's Disease? 10. Anger 11. Making Babies 12. Staying Positive 13. Exercise 14. Caring 15. Guilt 16. Journaling 17. Planning Ahead 18. Following the Latest Developments in Huntington's Disease News 19. Is Huntington's Disease Genetic Testing Even Worth the Trouble? 20. When Symptoms Start 21. I Look Forward to The Day When There Won't Be A Need for This Book 22. Calls to Action ---- What is Huntington's Disease?: Huntington's disease is a neurodegenerative disease that affects parts of the brain and leads to behavioural, cognitive and movement disorder symptoms. HD is caused by a mutation in a specific gene, now known as the Huntington gene. Huntington's disease is tragic in that it affects people in their prime. Symptoms often begin between the ages of 30- to 50-years-old. Currently, there is no cure for HD and once those affected become symptomatic, death usually occurs in 10-15 years. ---- About the author: Steven Beatty is part of a Huntington's disease family himself and received a positive result on his HD predictive genetic testing in 2015. Since that time, he has developed a passion directed at advocating for the Huntington's disease community. ---- The Huntington Society of Canada is a not-for-profit charitable organization which raises funds to deliver individual and group counselling service to support individuals and families living with Huntington disease (HD) and to fund medical research to delay or stop the progression of the disease

Can You Help Me

Can You Help Me  Book
Author : Thomas D. Bird MD
Publisher : Oxford University Press
Release : 2019-02-01
ISBN : 0190684240
Language : En, Es, Fr & De

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Book Description :

Can You Help Me?: Living in the Turbulent World of Huntington Disease shares the surprising, insightful, challenging, and even encouraging stories of patients and their families who live with Huntington Disease. Having seen patients for more than 40 years, Dr Thomas Bird, a pioneer neurogeneticist, adds a human touch to this genetic brain disease that devastates persons during mid-life when they can least afford it. With a brief history of Huntington Disease and the occasional scientific detail, the true heart of the book is the human experience of the disorder: · The man who cannot stay out of prison because he is addicted to being a burglar. · Another man shoots and kills his roommate while watching television and cannot explain why he did it. · The woman with Huntington Disease copes with her depression by using Texas line dancing. · A twelve year old girl with juvenile Huntington Disease who can barely walk and talk, but her classmates rally around with touching and heartfelt support. · And the 72 year old man with late onset Huntington Disease and severe depression is made worse by ECT, but improved (for a while) with Transcranial Magnetic Stimulation. These are just some of the compelling stories of people of all ages and in all walks of life who feel trapped by a progressive degenerative brain disease from which there is no escape.

Huntington s Disease

Huntington s Disease Book
Author : Anonim
Publisher : Lichtenstein Creative Media
Release : 2021-07-30
ISBN : 1932479570
Language : En, Es, Fr & De

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Book Description :

Download Huntington s Disease book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.