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Human Prion Diseases

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Human Prion Diseases

Human Prion Diseases Book
Author : Anonim
Publisher : Elsevier
Release : 2018-06-07
ISBN : 0444639535
Language : En, Es, Fr & De

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Book Description :

Human Prion Diseases, Volume 153 is designed to update the reader on the latest advances and clinical aspects of prion diseases. The book is organized into five sections, including the pathophysiology of prions and a description of animal and human diseases. This is followed by detailed reports on recent advances in diagnosis strategies for the development of novel anti-prion molecules and possible designs of clinical trials in such a rare disease. An introductory chapter gives an extensive historical background of prion research, with a final chapter highlighting recent progress, and more importantly, unsolved problems. Offers an authoritative overview of prion diseases in humans, detailing the pathogenesis of the disease, clinical investigations, and the diagnosis of both the genetic and acquired forms Provides clarity and context by presenting prion diseases in relation to other neurodegenerative diseases in humans Emphasizes the unique properties of prion diseases and consequent problems they can cause, both clinically and in public health terms

Neuropathology of Neurodegenerative Diseases Book and Online

Neuropathology of Neurodegenerative Diseases Book and Online Book
Author : Gabor G. Kovacs
Publisher : Cambridge University Press
Release : 2014-12-04
ISBN : 1107442427
Language : En, Es, Fr & De

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Book Description :

This heavily illustrated, must-have practical guide aids medical specialists and trainees in the diagnosis of neurodegenerative diseases. Includes diagnostic algorithms.

Prions and Diseases

Prions and Diseases Book
Author : Wen-Quan Zou,Pierluigi Gambetti
Publisher : Springer
Release : 2012-11-13
ISBN : 9781461453048
Language : En, Es, Fr & De

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Book Description :

Volume I highlights the association of the cellular prion protein (PrPC) with copper and zinc, the potential roles of PrPC in Alzheimer’s disease and cancers, insoluble PrPC, PMCA, molecular and cellular mechanisms of PrPSc formation and clearance, possible co-factors involved in the conversion of PrPC into PrPSc, infectious and pathogenic forms of PrP, cell biology of prions, prion strains and their interference, as well as yeast prions and their inheritable and structural traits. This unique volume will take you through the fascinating chronicle of prions in mammals, yeast, and fungi.

Prions

Prions Book
Author : Claudio Soto
Publisher : CRC Press
Release : 2005-12-20
ISBN : 142004012X
Language : En, Es, Fr & De

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Book Description :

Prion-related diseases, known as transmissible spongiform encephalopathies (TSEs), are infectious, fatal neurodegenerative disorders for which there is no cure, treatment, nor even a means for early diagnosis. The horrific advent of Mad Cow Disease -- transmitted to humans through eating meat from steers sickened by bovine spongiform encephalopathy

Prions

Prions Book
Author : Ivo Nikolaev Sirakov
Publisher : BoD – Books on Demand
Release : 2019-01-30
ISBN : 1789850177
Language : En, Es, Fr & De

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Book Description :

The cellular prion protein (PrPC) is expressed as a cell surface protein mainly in the central and peripheral nervous system. The discovery that prions are infectious agents changed the concept of protein synthesis in modern biology and built a bridge between the genesis of infectious and genetic diseases. This book discusses the normal function of the PrPC and its modulatory role in synaptic mechanisms. It describes the pathophysiological processes that accompany TSE - neurotoxicity, loss of anti-inflammatory protective function, neuronal death including prion-induced autophagy and apoptosis, and accumulation of PrPSc in the cytoplasm of neurons. Another aspect outlined here is that some prion diseases show strain variations that determine their development, demonstrating their key role in the development and progression of TSE.

Prion

Prion Book
Author : Yusuf Tutar
Publisher : BoD – Books on Demand
Release : 2017-03-08
ISBN : 9535130013
Language : En, Es, Fr & De

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Book Description :

Protein aggregation causes malfunction in several biochemical processes. Genetic and spontaneous formations of these transmissible spongiform encephalopathies are fatal to humans and animals. Conformational change of normal form of the protein to misfolded form causes its accumulation. The misfolded infectious protein agent forms the pathogenesis of the disease. This book presents pathology of the disease along with current knowledge of the structure-activity mechanism in the first two sections. Dyshomeostasis of metals is implicated in the pathogenesis of prions, and this influence is discussed further to understand the prion mechanism. Genetic resistance and immunobiology of the disease are elaborated in the following section. Finally, a computational study on the dynamics of the prion propagation provides a structural basis of the mechanism.

The Prion Protein

The Prion Protein Book
Author : Jorg Tatzelt
Publisher : Unknown
Release : 2010
ISBN : 9780954333522
Language : En, Es, Fr & De

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Book Description :

A conformational transition of the cellular prion protein (PrPC) into an aberrantly folded isoform designated scrapie prion protein (PrPSc) is the hallmark of a variety of neurodegenerative disorders collectively called prion diseases. They include Creutzfeldt-Jakob disease and Gerstmann-Stäussler-Scheinker syndrome in humans, scrapie in sheep, bovine spongiform encephalopathy (BSE) in cattle and chronic wasting disease (CWD) in free-ranging deer. In contrast to the deadly properties of misfolded PrP, PrPC seems to possess a neuroprotective activity. More-over, animal models indicated that the stress-protective activity of PrPC and the neurotoxic effects of PrPSc are somehow interconnected. In this timely book, leading scientists in the field have come together to highlight the apparently incongruous activities of different PrP conformers. The articles outline current research on celluar pathways implicated in the formation and signaling of neurotoxic and physiological PrP isoforms and delineate future research direction. Topics covered include the physiologcial activity of PrPC and its possible role as a neurotrophic factor, the finding that aberrant PrP conformers can cause neurodegeneration in the absence of infectious prion propagation, the requirement of the GPI anchor of PrPC for the neurotoxic effects of scrapie prions, the pathways implicated in the formation and neurotoxic properties of cytosolically localized PrP, the impact of metal ions on the processing of PrP, and the role of autophagy in the propagation and clearance of PrPSc. The book is fully illustrated and chapters include comprehensive reference sections. Essential reading for scientists involved in prion research.

Prions in Humans and Animals

Prions in Humans and Animals Book
Author : Beat Hörnlimann,Detlev Riesner,Hans A. Kretzschmar
Publisher : Walter de Gruyter
Release : 2006-01-01
ISBN : 3110200171
Language : En, Es, Fr & De

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Book Description :

This comprehensive work, aimed at both students and researchers alike, systematically covers all aspects of prion diseases (transmissible spongiform encephalopathies), from their history, microbiology and pathology to their transmissibility and prevention. The book describes diseases such as Creutzfeldt-Jakob disease, kuru, mad cow disease (BSE), chronic wasting disease and scrapie, highlighting their biochemical, molecular biological, genetic, and clinical aspects. A renowned editorial team brought together 80 internationally respected authors for this translation and new edition of the successful German publication. The book includes chapters by, among many other notable scientists, William J. Hadlow, who discovered the relationship between the human and animal forms of prion diseases and Michael P. Alpers, with 45 years of experience in Papua New Guinea investigating the first known human epidemic form, kuru, transmitted by endocannibalism. Carefully edited with numerous illustrations, this work offers a systematic approach committed to a clear presentation of the current knowledge of prion diseases. It aims to inspire and stimulate interdisciplinary cooperation, innovative research ideas and effective prevention.

Advancing Prion Science

Advancing Prion Science Book
Author : Institute of Medicine,Medical Follow-up Agency,Committee on Transmissible Spongiform Encephalopathies: Assessment of Relevant Science
Publisher : National Academies Press
Release : 2004-04-04
ISBN : 0309090601
Language : En, Es, Fr & De

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Book Description :

In Advancing Prion Science, the Institute of Medicine's Committee on Transmissible Spongiform Encephalopathies Assessment of Relevant Science recommends priorities for research and investment to the Department of Defense's National Prion Research Program (NPRP). Transmissible spongiform encephalopathies (TSEs), also called prion diseases, are invariably fatal neurodegenerative infectious diseases that include bovine spongiform encephalopathy (commonly called mad cow disease), chronic wasting disease, scrapie, and Creutzfeldt-Jakob disease. To develop antemortem diagnostics or therapies for TSEs, the committee concludes that NPRP should invest in basic research specifically to elucidate the structural features of prions, the molecular mechanisms of prion replication, the mechanisms of TSE pathogenesis, and the physiological function of prions' normal cellular isoform. Advancing Prion Science provides the first comprehensive reference on present knowledge about all aspects of TSEsâ€"from basic science to the U.S. research infrastructure, from diagnostics to surveillance, and from prevention to treatment.

Neurodegenerative Diseases

Neurodegenerative Diseases Book
Author : Shamim I. Ahmad
Publisher : Springer Science & Business Media
Release : 2012-03-12
ISBN : 1461406536
Language : En, Es, Fr & De

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Book Description :

The editor of this volume, having research interests in the field of ROS production and the damage to cellular systems, has identified a number of enzymes showing ·OH scavenging activities details of which are anticipated to be published in the near future as confirmatory experiments are awaited. It is hoped that the information presented in this book on NDs will stimulate both expert and novice researchers in the field with excellent overviews of the current status of research and pointers to future research goals. Clinicians, nurses as well as families and caregivers should also benefit from the material presented in handling and treating their specialised cases. Also the insights gained should be valuable for further understanding of the diseases at molecular levels and should lead to development of new biomarkers, novel diagnostic tools and more effective therapeutic drugs to treat the clinical problems raised by these devastating diseases.

Mad Cow Disease and Related Spongiform Encephalopathies

Mad Cow Disease and Related Spongiform Encephalopathies Book
Author : David A. Harris
Publisher : Springer Science & Business Media
Release : 2004-03-18
ISBN : 9783540201076
Language : En, Es, Fr & De

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Book Description :

Bovine spongiform encephalopathy (BSE) has become the most publicly recognizable example of a group of fatal neurodegenerative diseases caused by proteinaceous infectious particles called prions. The contributors to this volume, all internationally recognized experts in their fields, provide an introduction to prion biology, followed by reviews of the latest information on BSE, vCJD, and chronic wasting disease, an animal prion disease that has recently emerged in North America.

Prions and Diseases

Prions and Diseases Book
Author : Wen-Quan Zou,Pierluigi Gambetti
Publisher : Springer Science & Business Media
Release : 2012-11-08
ISBN : 1461453380
Language : En, Es, Fr & De

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Book Description :

Volume II features a variety of animal and human prion diseases, including the newly-identified atypical forms of bovine spongiform encephalopathy and scrapie in animals, and variably protease-sensitive prionopathy in humans, prions in the environment, Tau pathology in human prion disease, transmission of the disease by blood transfusion, mammalian and non-mammalian models, conventional and advanced diagnoses, prion-specific antibodies, as well as decontamination of prions and development of therapeutics of prion diseases, such as the application of immunomodulation. This volume provides up-to-date knowledge about the etiology, pathogenesis, classification, histopathological, and clinical aspects of the highly publicized animal and human prion diseases.

PrPSc Prions State of the Art

PrPSc Prions  State of the Art Book
Author : Joaquín Castilla,Jesús R. Requena
Publisher : MDPI
Release : 2018-11-07
ISBN : 3038973084
Language : En, Es, Fr & De

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Book Description :

This book is a printed edition of the Special Issue "PrPSc prions: state of the art" that was published in Pathogens

Clinical Infectious Diseases Study Guide

Clinical Infectious Diseases Study Guide Book
Author : Joseph Domachowske,Manika Suryadevara
Publisher : Springer Nature
Release : 2020-08-05
ISBN : 3030508730
Language : En, Es, Fr & De

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Book Description :

This book is meticulously designed for the busy student, trainee, or seasoned physician looking to enhance or refresh skills in infectious diseases. It is intended to provide a solid resource for students and physicians in need of a concise yet comprehensive background of the material. Each chapter begins with a summary of the topic, a brief case description, definitions, critical teaching points, and tables, figures, photos, and other visual materials to reinforce learning. The chapters take a systems based approach to infections before concluding with the essentials of diagnostic microbiology to leave users with a practical toolkit for real-world clinics. Authored by two expert educators and dual infectious diseases and pediatrics specialists, Clinical Infectious Diseases Study Guide is the only updated study guide designed for medical students, fellows, residents, and trainees who need a strong foundation in infectious diseases. This includes infectious disease specialists in both adult and pediatric care, various internal medicine subspecialists, and hospitalists.

Infectious Diseases from Nature Mechanisms of Viral Emergence and Persistence

Infectious Diseases from Nature  Mechanisms of Viral Emergence and Persistence Book
Author : C.J. Peters,Charles H. Calisher
Publisher : Springer Science & Business Media
Release : 2006-06-07
ISBN : 3211299815
Language : En, Es, Fr & De

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Book Description :

Significant zoonotic diseases have appeared with increasing frequency in recent years. At a symposium held in Galveston, Texas, in March 2004, many outstanding virologists and others presented papers under the broad theme of "emergence". The intent was to elucidate the diseases themselves, the mechanisms by which they have emerged, the publication perception and response to the diseases, and the possibility of prevention or prediction. The papers in this book summarize the talks of this meeting. Among the many timely papers are those by Nobel Prize winner Peter Doherty, influenza epidemiologists Robert Webster and Jeffery Taubenberger, and important contributions by Neal Nathanson, Esteban Domingo, Barry Beaty, David Walker, James Hughes, and others of world expertise.

Deadly Feasts

Deadly Feasts Book
Author : Richard Rhodes
Publisher : Simon and Schuster
Release : 2012-12-11
ISBN : 1471104575
Language : En, Es, Fr & De

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Book Description :

In this brilliant and gripping medical detective story. Richard Rhodes follows virus hunters on three continents as they track the emergence of a deadly new brain disease that first kills cannibals in New Guinea, then cattle and young people in Britain and France -- and that has already been traced to food animals in the United States. In a new Afterword for the paperback, Rhodes reports the latest U.S. and worldwide developments of a burgeoning global threat.

Prion Biology

Prion Biology Book
Author : Stanley B. Prusiner
Publisher : Unknown
Release : 2017-04-30
ISBN : 9781621820932
Language : En, Es, Fr & De

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Book Description :

Diseases such as CreutzfeldtJakob disease and kuru develop when certain proteins form prions by misfolding, clumping together, and spreading from cell to cell. Over the past decade, a number of proteins have been reported to possess prion-like characteristics, and many of these are associated with important human diseases such as Alzheimer's and type 2 diabetes. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine covers the progress that has recently been made in our understanding of the pathophysiology of prion diseases, as well as ongoing efforts to develop therapeutics. The contributors discuss how proteins such as tau, islet amyloid polypeptide, and a-synuclein aggregate, spread in a prion-like manner, and contribute to various neurodegenerative and extracerebral diseases. Human and animal diseases caused by the prion protein PrP are also covered, as are efforts to develop immunotherapeutics, protein disaggregases, and other drugs to delay or halt their progression. The authors discuss the development and use of cell culture and animal models of prion diseases, as well as the technologies and small molecules that are being used to study them. This volume is therefore useful for all biomedical scientists and physicians wishing to understand and treat this expanding group of devastating diseases.

Prion Biology

Prion Biology Book
Author : Vincent Béringue
Publisher : CRC Press
Release : 2013-04-08
ISBN : 1466578165
Language : En, Es, Fr & De

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Book Description :

This title includes a number of Open Access chapters. This book contains a selection of chapters aimed to provide a better understanding prion structure and biology. Together these chapters provide an overview of prion biology and underscore some of the challenges we face if we want to understand how this lively pathogen propagates and evolves in mammals. There is also mounting evidence that studying prion biology has a wider relevance due to similarities in the processes of protein misfolding and aggregation between prion disorders and other neurodegenerative disorders such as Alzheimer’s, Parkinson’s, and Huntington’s diseases.

Prion Diseases

Prion Diseases Book
Author : John Collinge (MD.),Mark S. Palmer,Mark S.. Palmer
Publisher : Oxford University Press, USA
Release : 1997
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

The number of neurological conditions associated with the mutant "prion" protein continues to grow. The list includes BSE and scrapie, which affect cattle and sheep respectively, and Creutzfeldt-Jacob Disease, which affects humans. This is an area of intense interest to neuroscientists,veterinary scientists, and clinicians. It has also attracted significant media attention because of the potential risks to humans. This book brings together leading researchers in the field to provide the most up-to-date and authoritative summary available of the field. Contents include human and animal prion diseases; pathology and cell biology of prion diseases; and prion protein structure.

Neurodegeneration

Neurodegeneration Book
Author : Ted M. Dawson
Publisher : John Wiley & Sons
Release : 2017-04-24
ISBN : 0470672684
Language : En, Es, Fr & De

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Book Description :

This book unites the diverse range of complex neurodegenerative diseases into a textbook designed for clinical practice, edited by globally leading authorities on the subject. Presents a clinically oriented guide to the diseases caused by neurodegeneration Templated chapters combine clinical and research information on neurodegenerative diseases beginning with the common elements before treating each disease individually Diseases are grouped by anatomical regions of degeneration and include common disorders such as Parkinson’s Disease, Alzheimer’s Disease, Amyotrophic Lateral Sclerosis/Motor Neuron Disease, and Multiple Sclerosis as well as less common diseases Edited by globally leading authorities on the subject, and written by expert contributing authors