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Human Chorionic Gonadotropin

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Human Chorionic Gonadotropin hCG

Human Chorionic Gonadotropin  hCG  Book
Author : Laurence A. Cole
Publisher : Elsevier
Release : 2014-12-11
ISBN : 0128008210
Language : En, Es, Fr & De

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Book Description :

Human chorionic gonadotropin (hCG) is produced during pregnancy by the embryo. It promotes progesterone production by corpus luteal cells. It also functions in pregnancy to promote angiogenesis in uterine vasculature, it immuno-blands the invading placental tissue so it is not rejected by the maternal uterine tissues, promotes the growth of the uterus in line with the growth of the fetus, promotes the differentiation of growing cytotrophoblast cells, promotes the quiescence of contractions in the uterine myometrium during the course of pregnancy, and also has function in growth and development of fetal organs. The first edition described the detailed biology, clinical chemistry, and clinical perspectives of hCG and associated molecules, and examines hCG, hyperglycosylated hCG and hCG free ß-subunit, 3 separate and independent molecules with totally sovereign physiological functions. The second edition will include coverage of the many new discoveries that have been made in the last five years: hCG analogues may be the actual driving signal of all human cancers. The editor estimates that 40% of the out of date material will be excluded and replaced with 40% of the exciting new findings. The book will also have a much clearer pregnancy and cancer focus. It provides comprehensive information on hCG from basic science to clinical medicine The second edition will include coverage of the many new discoveries that have been made in the last five years Updated material with new findings in the field

100 Years of Human Chorionic Gonadotropin

100 Years of Human Chorionic Gonadotropin Book
Author : Laurence A. Cole,Stephen A. Butler
Publisher : Unknown
Release : 2020-02-17
ISBN : 0128200502
Language : En, Es, Fr & De

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100 years of Human Chorionic Gonadotropin: Reviews and New Perspectives is a collection of articles written by some of the world's leading experts on the pregnancy hormone and cancer marker hCG. In 2019 it is difficult to ignore the effect that our understanding of hCG has had on the lives of millions of people worldwide. The hCG immunoassay, in one form or another, is now one of the most common medical tests conducted and is often the first indication that a mother-to-be is pregnant. Not only a marker of pregnancy, hCG is utilized in the diagnosis and monitoring in oncology and presents a potential target for novel cancer therapeutics. 100 years ago, in 1919, Hirose was demonstrating gonadotropic functions which resulted from a chorionic factor. Over the last century this factor has become defined as hCG and more recently explored as not one molecule but a group of molecules with variable structure and variable functions in both pregnancy and cancer. hCG is a multi-faceted molecule that has clinical and therapeutic implications but can be a challenging topic for researchers and physicians alike. This text covers the different structures and functions of hCG exploring the genes and evolution of the molecule, the different protein and glycosylation structures which can exist and their effect on structure, detection and quantification. 100 Years of hCG is not an attempt to recount the history of every publication on hCG, but rather a collection of reviews and new perspectives by "hCG-ologists", the term used by Hussa to describe biochemists working on HCG in the first book written on the topic over 30 years ago. Some of the authors have been around a while, some not so long, but others are just beginning their journey with a most beguiling molecule. Provides updated information on a complex and changing subject in five sections Reviews historical perspectives and developments over the last 100 years Includes novel insights into the structure, function and detection of hCG in pregnancy and cancer Includes chapters on the use of mass spectrometry to detect and quantify hCG as well as traditional immunoassays and over the counter pregnancy tests Describes the role of hCG in pregnancy, endometrial receptivity and embryo implantation and the use in fertility treatment Addresses the specific hyperglycosylated hCG test that can distinguish a normal term from a failing pregnancy and also screen for preeclampsia and gestational hypertension in pregnancy as well as its use as a marker and treatment target in cancer. Includes chapters on the development and use of hCG vaccines Includes a section on hCG and in subunits in cancer

Human Chorionic Gonadotropin hCG In Oligospermic Male

Human Chorionic Gonadotropin  hCG   In Oligospermic Male Book
Author : Mazhar Mushtaq
Publisher : Unknown
Release : 2017-01-07
ISBN : 9783330805798
Language : En, Es, Fr & De

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Download Human Chorionic Gonadotropin hCG In Oligospermic Male book written by Mazhar Mushtaq, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Radioimmunoassay of Human Chorionic Gonadotropin

Radioimmunoassay of Human Chorionic Gonadotropin Book
Author : Wallac
Publisher : Unknown
Release : 1982
ISBN : 9789519489094
Language : En, Es, Fr & De

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Download Radioimmunoassay of Human Chorionic Gonadotropin book written by Wallac, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Role of Human Chorionic Gonadotropin Hcg on Embryo Attachment Onto Oviductal Epithelial Cells Through Downregulation of Olfactomedin 1 Olfm1

Role of Human Chorionic Gonadotropin  Hcg  on Embryo Attachment Onto Oviductal Epithelial Cells Through Downregulation of Olfactomedin 1  Olfm1  Book
Author : Kam-Hei So,蘇錦熙
Publisher : Open Dissertation Press
Release : 2017-01-26
ISBN : 9781361028384
Language : En, Es, Fr & De

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This dissertation, "Role of Human Chorionic Gonadotropin (HCG) on Embryo Attachment Onto Oviductal Epithelial Cells Through Downregulation of Olfactomedin-1 (OLFM1)" by Kam-hei, So, 蘇錦熙, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. Abstract: Tubal ectopic pregnancy (TEP) occurs in 2% of pregnancy and is potentially fatal to pregnant women because of the risk of Fallopian tube/oviduct rupture. The causes of ectopic pregnancy are associated with pelvic infection, tobacco smoking and the use of assisted reproductive technology. However, the underlying mechanism leading to TEP remains largely unknown. Results from recent studies suggested that human chorionic gonadotrophin (hCG) stimulates miRNA expression in female reproductive tract and miRNAs play important roles on various biological processes. In silico analysis identified miRNA-212 may regulate Olfactomedin-1 (Olfm1) expression which was found to be down-regulated in endometrial epithelium during embryo implantation. Therefore, we hypothesized that embryo-derived hCG stimulates miRNA-212 expression, down-regulated Olfm1 expression in the Fallopian epithelium and favor embryo attachment leading to ectopic pregnancy. Furthermore, the effect of hCG binding onto LH/CG receptor (LH/CGR) and the downstream protein kinase and Wnt signaling pathways was investigated. It was found that Olfm1 was down-regulated and LH/CGR was up-regulated at the luteal phase of the menstrual cycle in the human Fallopian tube. hCG (25IU/ml) down-regulated Olfm1 in human oviductal epithelial cells (OE-E6/E7). Both hCG (25IU/ml) and hCG beta subunit increased JAR spheroids (blastocyst surrogate) attachment rate onto OE-E6/E7 cells. Knockdown of LH/CGR siRNA reduces, while knockdown of Olfm1 siRNA increases spheroids attachment, respectively. Progesterone (60nM) increased attachment rate and up-regulated the expression of LH/CGR. LH/CGR could activate its downstream signaling pathways through either protein kinase A or protein kinase C. PKA activator (Forskolin) has no effect on spheroid attachment; while PKC activator (PMA) increased attachment rate, suggesting hCG promotes spheroids attachment through PKC signaling pathway. Furthermore, hCG activates Erk and Wnt signaling pathways; while knockdown of LH/CGR abolished the effect of hCG on Erk activation in OE-E6/E7 cells. Similarly, Erk or Wnt activator down-regulated Olfm1, while Erk or Wnt inhibitor up-regulated Olfm1 expression and stimulates spheroid attachment in OE-E6/E7 cells. In line with this, immunohistochemistry of human Fallopian tubes obtained from ectopic pregnancy and normal non-pregnant women showed activation of Erk signaling pathway in the epithelium of TEP samples. In silico analysis of the promoter region of hsa-miR212 revealed binding site of LEF-1, a Wnt signaling transcriptional factor. Chromatin immunoprecipitaiton showed binding of LEF-1 to the promoter region of hsa-miR212. Hsa-miR212 mimic down-regulated Olfm1 and promoted spheroids attachment; while hsa-miR212 inhibitor up-regulated Olfm1 and suppressed spheroids attachment. To summarize, our results demonstrated that hCG (25IU/ml) act through LH/CGR, activates Erk and Wnt signaling pathways, induces miR-212 expression and down-regulates Olfm1, which favors embryo attached onto oviductal epithelial cells for TEP. Subjects: Epithelial cells Chorionic gonadotropins Embryology, Human Oviduct

Correlation of Vitamin a Status and Serum Human Chorionic Gonadotropin beta HCG Levels with Birth Weight and Placental Weight in Multiparous Black Women

Correlation of Vitamin a Status and Serum Human Chorionic Gonadotropin   beta  HCG  Levels with Birth Weight and Placental Weight in Multiparous Black Women Book
Author : Chitua Okoh-Obineche
Publisher : Unknown
Release : 1987
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Download Correlation of Vitamin a Status and Serum Human Chorionic Gonadotropin beta HCG Levels with Birth Weight and Placental Weight in Multiparous Black Women book written by Chitua Okoh-Obineche, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Folding and Dimer Formation of the Human Chorionic Gonadotropin hCG Subunits

Folding and Dimer Formation of the Human Chorionic Gonadotropin  hCG  Subunits Book
Author : Jordi Roig Camacho
Publisher : Unknown
Release : 2006
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Download Folding and Dimer Formation of the Human Chorionic Gonadotropin hCG Subunits book written by Jordi Roig Camacho, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Post translational Processing and Internalization of the Luteinizing Hormone human Chorionic Gonadotropin Receptor

Post translational Processing and Internalization of the Luteinizing Hormone human Chorionic Gonadotropin Receptor Book
Author : Faye Andrea Bradbury
Publisher : Unknown
Release : 2000
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Download Post translational Processing and Internalization of the Luteinizing Hormone human Chorionic Gonadotropin Receptor book written by Faye Andrea Bradbury, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Aspects of Binding of Human Chorionic Gonadotropin HCG in Rat Serum Proteins

Aspects of Binding of Human Chorionic Gonadotropin  HCG  in Rat Serum Proteins Book
Author : J. Charles Eldridge
Publisher : Unknown
Release : 1967
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Download Aspects of Binding of Human Chorionic Gonadotropin HCG in Rat Serum Proteins book written by J. Charles Eldridge, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Chorionic Gonadotropin

Chorionic Gonadotropin Book
Author : Sheldon J. Segal
Publisher : Springer Science & Business Media
Release : 2012-12-06
ISBN : 1468410628
Language : En, Es, Fr & De

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This volume is devoted to the chemistry, immunology, molecular biology, and physiology of the human chorionic gonadotropin, heG. For this glycoprotein molecule the course from discovery to chemical deciphering covered about fifty years. It was in 1928 that Ascheim and Zondek reported that urine from pregnant women contains something that stimulates the ovaries of mice or rats. This provided the basis for the famous A-Z test for pregnancy and for the "rabbit test" modification introduced by Friedman. As researchers sought to find more sensitive responses to heG, they used a wide variety of species including the South African aquatic toad, Xenopus Zaevis, the terrestrial toad of South America, Bufo arinarus, and the African weaver finch, EupZeetes afra. The weaver finch feather reaction was particularly noteworthy, for it disclosed a non-gonadal response to heG/LH. In retrospect, this may have been an important evolutionary clue to the realization that the designation of the hormone as a "gonadotropin" may have been only partially descriptive of the molecule's physiological function--a concept that is gaining attention, as the papers in this 1980 volume divulge.

Placental Free Alpha Subunit of Human Chorionic Gonadotropin hCG

Placental Free Alpha Subunit of Human Chorionic Gonadotropin  hCG  Book
Author : Elizabeth Gross Posillico
Publisher : Unknown
Release : 1982
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Download Placental Free Alpha Subunit of Human Chorionic Gonadotropin hCG book written by Elizabeth Gross Posillico, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

It Starts Before They Can Talk

It Starts Before They Can Talk Book
Author : Anonim
Publisher : Unknown
Release : 2007
ISBN : 0987650XXX
Language : En, Es, Fr & De

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An Investigation of Human Chorionic Gonadotropin in Early Pregnancy

An Investigation of Human Chorionic Gonadotropin in Early Pregnancy Book
Author : Reginald Armitage Smith
Publisher : Unknown
Release : 1951
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Download An Investigation of Human Chorionic Gonadotropin in Early Pregnancy book written by Reginald Armitage Smith, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Presence of Luteinizing Hormone human Chorionic Gonadotropin hCG Receptors and the Up regulating Action of HCG on 5 lipoxygenase Gene Expression in Immortalized Hippocampal HN33p Neurons

Presence of Luteinizing Hormone human Chorionic Gonadotropin  hCG  Receptors and the Up regulating Action of HCG on 5 lipoxygenase Gene Expression in Immortalized Hippocampal HN33p Neurons Book
Author : Weihua Zhang
Publisher : Unknown
Release : 1998
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Download Presence of Luteinizing Hormone human Chorionic Gonadotropin hCG Receptors and the Up regulating Action of HCG on 5 lipoxygenase Gene Expression in Immortalized Hippocampal HN33p Neurons book written by Weihua Zhang, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Role of Human Chorionic Gonadotropin HCG on Embryo Attachment Onto Oviductal Epithelial Cells Through Downregulation of Olfactomedin 1 OLFM1

Role of Human Chorionic Gonadotropin  HCG  on Embryo Attachment Onto Oviductal Epithelial Cells Through Downregulation of Olfactomedin 1  OLFM1  Book
Author : 蘇錦熙
Publisher : Unknown
Release : 2015
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Download Role of Human Chorionic Gonadotropin HCG on Embryo Attachment Onto Oviductal Epithelial Cells Through Downregulation of Olfactomedin 1 OLFM1 book written by 蘇錦熙, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Biochemical Characterization Of Human Chorionic Gonadotropin and Its Receptors

Biochemical Characterization Of Human Chorionic Gonadotropin and Its Receptors Book
Author : Sami AL-Mudhaffar,Zainab Al-Azzawi,Sami a Al-Mudhaffar Dr
Publisher : Createspace Independent Publishing Platform
Release : 2015-05-10
ISBN : 9781512129052
Language : En, Es, Fr & De

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2. The presence and characterization of hCG in cytosolic homogenate of breast tumor tissues were investigated by a modified immunoradiometric Assay (IRMA). This method was found to be a suitable for the assessment of hCG in benign and malignant breast tumor.3. Different factors affecting the binding of hCG and 125I-ant hCG antibody, affinity constant and hCG concentration (Bmax) were studied.4. The presence and characterization of hCG in cytosolic homogenate of breast tumor tissues were investigated by using a modified radioreceptor assay (RRA). This method was found to be a suitable for the assessment of hCG-receptor in benign and malignant breast tumor.

Characterization of Small Immunoreactive Human Chorionic Gonadotropin like Substance Produced by Normal Placenta and by Human Chorionic Gonadotropin Secreting Neoplasms

Characterization of Small Immunoreactive Human Chorionic Gonadotropin like Substance Produced by Normal Placenta and by Human Chorionic Gonadotropin Secreting Neoplasms Book
Author : H. Robert Masure
Publisher : Unknown
Release : 1985
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Download Characterization of Small Immunoreactive Human Chorionic Gonadotropin like Substance Produced by Normal Placenta and by Human Chorionic Gonadotropin Secreting Neoplasms book written by H. Robert Masure, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.