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Hormonal Signaling In Biology And Medicine

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Hormonal Signaling in Biology and Medicine

Hormonal Signaling in Biology and Medicine Book
Author : Gerald Litwack
Publisher : Academic Press
Release : 2019-10-24
ISBN : 0128138157
Language : En, Es, Fr & De

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Book Description :

Hormonal Signaling in Biology and Medicine: Comprehensive Modern Endocrinology covers the endocrine secretions produced by every organ. This extensive collection of knowledge is organized by tissue, addressing how certain hormones are synthesized in multiple tissues, along with their structure, function and pathways, which are very applicable for researchers in drug design who need to focus on a specific step along the pathway. This is a must have reference for researchers in endocrinology and practicing endocrinologists, but it is also ideal for biochemists, pharmacologists, biologists and students. Serves as a valuable desk reference for researchers Provides information on the structure of a given hormone, its receptor(s), and the pathways that become activated Includes extensive citations to the literature that will enable the reader to dig more deeply into the effects of a given hormone

Hormones in Ageing and Longevity

Hormones in Ageing and Longevity Book
Author : Suresh Rattan,Ramesh Sharma
Publisher : Springer
Release : 2017-09-08
ISBN : 9783319630007
Language : En, Es, Fr & De

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Book Description :

This multi-chapter book focuses on one of the hottest topics in ageing research – the role of hormones in health and longevity, offering a comprehensive and up-to-date overview of their mechanistic roles in health, ageing and longevity. Hormones are an excellent system of communication between cells and tissues within an organism, and they coordinate a wide range of processes in biological systems, including neuroendocrine and immunological controls. The book offers insights into the latest significant advances in our understanding of the mechanisms of hormonal signaling that control a variety of processes involved in development and ageing. It is divided into four parts: Part I includes a review of the hundred-year history of hormones by the illustrious hormone biochemist Dr. J.R. Tata. Part II presents various chapters on the hormones involved in growth, stress and metabolism, while Part III addresses the hormones controlling cognition and rhythms in ageing processes. Lastly, Part IV discusses the hormones affecting reproduction, immunity and life span. It also explores the use of hormones as pharmaceuticals to maintain health in the elderly. It is a valuable resource for those working in the area of hormone signaling in general and in the field of ageing research in particular.

Hormones and Signaling

Hormones and Signaling Book
Author : Anonim
Publisher : Elsevier
Release : 1999-10-25
ISBN : 0080522394
Language : En, Es, Fr & De

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Book Description :

Hormones and Signaling focuses on the mechanisms of gene regulation at the cellular level. It also describes the actions of hormones in modulating gene regulation and animal development. Glococorticoid and mineralcorticoid signaling Orphan nuclear receptors Nuclear receptor coactivators Cytokines and STAT signaling Coordination of cAMP signaling events through PKA anchoring G protein-coupled extracellular Ca2+ (Ca2+0)-sensing receptor (CaR) Pancreatic islet development Genetic analysis of androgen receptors in development and disease Antioprogestin regulable gene switch for induction of gene expression in vivo Steroid receptor knockout model

Harrison s Endocrinology 3E

Harrison s Endocrinology  3E Book
Author : J. Larry Jameson
Publisher : McGraw Hill Professional
Release : 2013-03-22
ISBN : 0071814876
Language : En, Es, Fr & De

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Book Description :

Endocrinology – as only HARRISON’S can cover it Featuring a superb compilation of chapters on endocrinology that appear in Harrison’s Principles of Internal Medicine, Eighteenth Edition, this concise, full-color clinical companion delivers the latest knowledge in the field backed by the scientific rigor and authority that have defined Harrison’s. You will find content from renowned editors and contributors in a carry-anywhere presentation that is ideal for the classroom, clinic, ward, or exam/certification preparation. Features An organization that reflects the physiologic roots of endocrinology: Pituitary, Thyroid, and Adrenal Disorders; Reproductive Endocrinology; Diabetes Mellitus, Obesity, Lipoprotein Metabolism; Disorders Affecting Multiple Endocrine Systems; and Disorders of Bone and Calcium Metabolism An important introduction that uses numerous examples of translational research to link genetics, cell biology, and physiology with pathophysiology and treatment Integration of pathophysiology with clinical management 108 high-yield questions and answers drawn from Harrison’s Principles of Internal Medicine Self-Assessment and Board Review, 18e Updates and new developments since the publication of Harrison’s Principles of Internal Medicine, 18e 29 chapters written by physicians who are recognized experts in the field of endocrinology Helpful appendix of laboratory values of clinical importance

Hormone Signaling

Hormone Signaling Book
Author : Vincent Goffin,Paul A. Kelly
Publisher : Springer Science & Business Media
Release : 2013-03-09
ISBN : 1475736002
Language : En, Es, Fr & De

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Book Description :

Multicellular organisms require a means of intracellular communication to organize and develop the complex body plan that occurs during embryogenesis and then for cell and organ systems to access and respond to an ever changing environmental milieu. Mediators of this constant exchange of information are growth factors, neurotransmmitters, peptide and protein hormones which bind to cell surface receptors and transduce their signals from the extracellular space to the intracellular compartment. Via multiple signaling pathways, receptors of this general class affect growth, development and differentiation. Smaller hydrophobic signaling molecules, such as steroids and non-steroid hormones, vitamins and metabolic mediators interact with a large family of nuclear receptors. These receptors function as transcription factors affecting gene expression, to regulate the multiple aspects of animal and human physiology, including development, reproduction and homeostasis. The aim of this book is to cover various aspects of intracellular signaling involving hormone receptors.

Hormones

Hormones Book
Author : Anthony W. Norman,Gerald Litwack
Publisher : Academic Press
Release : 2014-06-28
ISBN : 1483258106
Language : En, Es, Fr & De

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Book Description :

Hormones provides a comprehensive treatment of human hormones viewed in the light of modern theories of hormone action and in the context of current understanding of subcellular and cellular architecture and classical organ physiology. The book begins with discussions of the first principles of hormone action and the seven classes of steroid hormones and their chemistry, biosynthesis, and metabolism. These are followed by separate chapters that address either a classical endocrine system, e.g., hypothalamic hormones, posterior pituitary hormones, anterior pituitary hormones, ,thyroid hormones, pancreatic hormones, gastrointestinal hormones, calcium regulating hormones, adrenal corticoids, hormones of the adrenal medulla, androgens, estrogens and progestins, and pregnancy and lactation hormones; or newer domains of hormone action which are essential to a comprehensive understanding of hormone action, including prostaglandins, thymus hormones, and pineal hormones. The book concludes with a presentation of hormones of the future, i.e., cell growth factors. This book is intended for use by first-year medical students, graduate students, and advanced undergraduates in the biological sciences. It is also hoped that this book will fill the void that exists for resource materials for teaching cellular and molecular endocrinology and that it will be employed as an equal partner with most standard biochemistry textbooks to provide a comprehensive and balanced coverage of this realm of biology.

Hormones

Hormones Book
Author : Anthony W. Norman,Helen L. Henry
Publisher : Academic Press
Release : 2022-01-13
ISBN : 0323984606
Language : En, Es, Fr & De

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Book Description :

Hormones, Fourth Edition provides a report on the field of human hormones viewed in light of our current understanding of cellular and subcellular architecture, along with the molecular details of their modes of action. Comprehensive information about hormone action on canonical and non-canonical signaling pathways at cellular and subcellular level and effects on architecture and function of organ systems are discussed. All chapters in this new edition have been completely updated to cover advances in endocrinology research, which has expanded significantly in the last few years. Vast coverage of hormones not previously covered and newly discovered aspects of hormone action are also included. This new fourth edition is intended to be used by advanced undergraduates and graduate students in the biological sciences. It will also provide useful background information for health professionals, clinicians and researchers in the field of endocrinology, metabolism and biochemistry. Includes updates on all chapters Covers sleep hormones, growth factors, intestinal hormones, calcium-sensing receptor of parathyroid, and others Provides essential basics for advanced undergraduates, graduate students and researchers in the biological sciences, as well as clinical aspects and applications for clinicians Presented in separate hormone systems, covering the subcellular mode of action of selected hormones and a detailed understanding of their human anatomy and physiology

Molecular Biology of the Cell

Molecular Biology of the Cell Book
Author : Bruce Alberts
Publisher : Unknown
Release : 2004
ISBN : 9780815332183
Language : En, Es, Fr & De

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Book Description :

Download Molecular Biology of the Cell book written by Bruce Alberts, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Hormone Signaling

Hormone Signaling Book
Author : Vincent Goffin,Paul A. Kelly
Publisher : Springer Science & Business Media
Release : 2002-03-31
ISBN : 9780792376606
Language : En, Es, Fr & De

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Book Description :

Multicellular organisms require a means of intracellular communication to organize and develop the complex body plan that occurs during embryogenesis and then for cell and organ systems to access and respond to an ever changing environmental milieu. Mediators of this constant exchange of information are growth factors, neurotransmmitters, peptide and protein hormones which bind to cell surface receptors and transduce their signals from the extracellular space to the intracellular compartment. Via multiple signaling pathways, receptors of this general class affect growth, development and differentiation. Smaller hydrophobic signaling molecules, such as steroids and non-steroid hormones, vitamins and metabolic mediators interact with a large family of nuclear receptors. These receptors function as transcription factors affecting gene expression, to regulate the multiple aspects of animal and human physiology, including development, reproduction and homeostasis. The aim of this book is to cover various aspects of intracellular signaling involving hormone receptors.

Cellular Endocrinology in Health and Disease

Cellular Endocrinology in Health and Disease Book
Author : Alfredo Ulloa-Aguirre,Ya-Xiong Tao
Publisher : Academic Press
Release : 2021-02-02
ISBN : 0128198028
Language : En, Es, Fr & De

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Book Description :

Cellular Endocrinology in Health and Disease, Second Edition, describes the underlying basis of endocrine function, providing an important tool to understand the fundamentals of endocrine diseases. Delivering a comprehensive review of the basic science of endocrinology, from cell biology to human disease, this work explores and dissects the function of a number of cellular systems. The new edition provides an understanding of how endocrine glands function by integrating information resulting in biological effects on both local and systemic levels, also providing new information on the molecular physiopathogenesis of endocrine neoplasic cells. The new edition expands the most used chapters from the first edition and proposes a series of substitutions and additions to the table of contents. New chapters cover signaling, brown adipose tissue, hypothalamic cell models, cellular basis of insulin resistance, genetics and epigenetics of neuroendocrine tumors, and a series of chapters on endocrine-related cancer. Providing content that crosses disciplines, Cellular Endocrinology in Health and Disease, Second Edition, details how cellular endocrine function contributes to system physiology and mediates endocrine disorders. A methods section proves novel and useful approaches across research focus that will be attractive to medical students, residents, and specialists in the field of endocrinology, as well as to those interested in cellular regulation. Editors Alfredo Ulloa-Aguirre and Ya-Xiong Tao, experts in molecular and cellular aspects of endocrinology, deliver contributions carefully selected for relevance, impact, and clarity of expression from leading field experts Explores endocrine cells biology in normal and pathologic conditions Covers new aspects of endocrine cell function in distinct tissues Provides a view into the biological effect in local and systemic levels 15 new chapters covering the recent developments in the field

Handbook of Hormones

Handbook of Hormones Book
Author : Yoshio Takei,Hironori Ando,Kazuyoshi Tsutsui
Publisher : Academic Press
Release : 2015-08-26
ISBN : 0128010673
Language : En, Es, Fr & De

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Book Description :

Handbook of Hormones: Comparative Endocrinology for Basic and Clinical Research collates fundamental information about the structure and function of hormones from basic biology to clinical use. The handbook offers a rapid way to obtain specific facts about the chemical and molecular characteristics of hormones, their receptors and signalling pathways, and the biological activities they regulate. The evolution of hormones and gene families is also covered both in the text and in online ancillaries. Users will find simple and visual ways to learn key molecular information. Chapters and online ancillary resources integrate additional sections, providing a comparative molecular, functional, and evolutionary consideration. Provides the only single resource available with concise, yet informative descriptions of hormones in vertebrates, invertebrates, and plants Presents hormones in groups according to their origin, so that readers can easily understand their inter-relation Includes comparative information on the structures and functions of hormones enabling readers to understand both general and specific actions in and across species Ancillary website hosts additional information, including sequence data, comparative data, figures, and tables

Human Biochemistry

Human Biochemistry Book
Author : Gerald Litwack
Publisher : Academic Press
Release : 2021-11-28
ISBN : 032391053X
Language : En, Es, Fr & De

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Book Description :

Human Biochemistry, Second Edition provides a comprehensive, pragmatic introduction to biochemistry as it relates to human development and disease. Here, Gerald Litwack, award-wining researcher and longtime teacher, discusses the biochemical aspects of organ systems and tissue, cells, proteins, enzymes, insulins and sugars, lipids, nucleic acids, amino acids, polypeptides, steroids, and vitamins and nutrition, among other topics. Fully updated to address recent advances, the new edition features fresh discussions on hypothalamic releasing hormones, DNA editing with CRISPR, new functions of cellular prions, plant-based diet and nutrition, and much more. Grounded in problem-driven learning, this new edition features clinical case studies, applications, chapter summaries, and review-based questions that translate basic biochemistry into clinical practice, thus empowering active clinicians, students and researchers. Presents an update on a past edition winner of the 2018 Most Promising New Textbook (College) Award (Texty) from the Textbook and Academic Authors Association and the PROSE Award of the Association of American Publishers Provides a fully updated resource on current research in human and medical biochemistry Includes clinical case studies, applications, chapter summaries and review-based questions Adopts a practice-based approach, reflecting the needs of both researchers and clinically oriented readers

Epidemiology of Endocrine Tumors

Epidemiology of Endocrine Tumors Book
Author : Jahangir Moini,Craig Badolato,Raheleh Ahangari
Publisher : Elsevier
Release : 2021-02-17
ISBN : 0128232668
Language : En, Es, Fr & De

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Book Description :

Epidemiology of Endocrine Tumors brings current data and clinical research into one source for a multidisciplinary audience. The book discusses the prevalence, incidence, etiology, pathology, diagnosis and treatment of various endocrine tumors. With clear and focused writing, it is essential reading for healthcare professionals, endocrinologists, oncologists, and public health professionals. Users will be able to bridge the knowledge gap that exists in the comprehensive coverage surrounding the epidemiology of endocrine tumors. Globally, the prevalence and incidence of endocrine tumors is high. This audience needs a treatise where they can gain a broad overview of endocrine tumors with a focus on epidemiology. Supplies information about the epidemiology of various endocrine tumors, both benign and malignant, to endocrinologists, oncologists and related health care professionals Focuses on the impact upon costs and patient deaths due to complications of these tumors Describes how endocrine tumors affect various age groups and ethnicities, discussing the prevention of endocrine tumors Presents chapters on Cancer Problem, Specific Endocrine Tumors, Prevention, Detection and Diagnosis, and Treatment of Endocrine Tumors Provides review questions with an answer key and detailed glossary

Plant Structural Biology Hormonal Regulations

Plant Structural Biology  Hormonal Regulations Book
Author : Jan Hejátko,Toshio Hakoshima
Publisher : Springer
Release : 2018-08-17
ISBN : 3319913522
Language : En, Es, Fr & De

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Book Description :

After decades of dominance of genetics and genomics, the importance of structural biology is growing exponentially in the field of plant biology. The main objectives of this new book series is to “demystify” structural biology for plant researchers and to provide important insights into the basic molecular mechanisms underlying plant development through the diverse approaches utilized by structural biologists. The book series starts with a theme dedicated to hormonal signaling that has benefited from the application of structural biology. “Plant Structural Biology: Hormonal Regulations” provides up-to-date knowledge of the structural aspects of hormonal signal recognition, signal transduction, hormonal control of downstream regulatory pathways and hormonal crosstalk. The most distinctive features of this book as well as future titles is/will be to provide overview of cutting-edge research in the field of plant structural biology, and to serve as a compendium of various approaches that could be applied to problems being solved in modern plant biology. Last but not least, we hope this book will facilitate and broaden the community of (not only) plant scientists who are interested in structural biology approaches and tools. For these reasons, the style of this series is concise and general, in order to avoiding unnecessary details. Explanatory boxes describing the basics of specific approaches (e.g. X-ray crystallography, NMR, SAXS, molecular dynamics simulations, etc.) are included.

Signal Transduction

Signal Transduction Book
Author : Bastien D. Gomperts,Ijsbrand M. Kramer,Peter E.R. Tatham
Publisher : Gulf Professional Publishing
Release : 2003-10-15
ISBN : 9780122896323
Language : En, Es, Fr & De

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Book Description :

Signal Transduction now in paperback, is a text reference on cellular signalling processes. Starting with the basics, it explains how cells respond to external cues (hormones, cytokines, neurotransmitters, adhesion molecules, extracellular matrix, etc), and shows how these inputs are integrated and co-ordinated. The first half of the book provides the conceptual framework, explaining the formation and action of second messengers, particulary cyclic nucleotides and calcium, and the mediation of signal pathways by GTP-binding proteins. The remaining chapters deal with the formation of complex signalling cascades employed by cytokines and adhesion molecules, starting at the membrane and ending in the nucleus, there to regulate gene transcription. In this context, growth is an important potential outcome and this has relevance to the cellular transformations that underlie cancer. The book ends with a description at the molecular level of how signalling proteins interact with their environment and with each other through their structural domains. Each main topic is introduced with a historical essay, detailing the sources key observations and experiments that set the scence for recent and current work. * Coherent, precise text providing insight in depth to a subject that is central to cell biology and fundamental to many areas of biomedicine * Conceptual colour artwork assists with the comprehension of key topics * Extensive referencing provides an invaluable link to the core and historical literature * Margin notes highlighting milestones in the evolution of our understanding of signalling mechanisms

Molecular Biology of Steroid and Nuclear Hormone Receptors

Molecular Biology of Steroid and Nuclear Hormone Receptors Book
Author : Leonard Freedman
Publisher : Springer Science & Business Media
Release : 2012-12-06
ISBN : 1461217644
Language : En, Es, Fr & De

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Book Description :

Intracellular Receptors: New Instruments for a Symphony of Signals In the late eighteenth century, it was proposed on theoretical grounds that each of the body's organs, beginning with the brain, must be "a factory and laboratory of a specific humor which it returns to the blood", and that these circulating signals "are indispensable for the life of the whole" (Bordeu 1775). During the nineteenth cen tury, some remarkable physiological experiments revealed the actions of humoral factors that affected the for and function of multiple tissues, organs and organ sys tems within the body (Berthold 1849); much later, the chemical and molecular na ture of some of those factors was determined. Against this deep historical backdrop of the founding studies of intercellular signaling, molecular biology sprang into existence a mere forty years ago, rooted in the revelation of regulable gene expression in bacteria. But contemporaneous with those classical analyses of transcriptional regulation of the lactose operon, the mod em era of signal transduction was inaugurated by the identification of cAMP as a second messenger -- an intracellular mediator of hormonal activation of glycogen catabolism (Sutherland and RaIl 1960). Later in that same decade, it emerged that cAMP is a critical signal not only in metazoans, but even in bacteria, where it serves an analogous function as a critical switch that activates expression of genes re quired for catabolism of complex carbon sources, including those of the lactose operon.

The Biology of Exercise

The Biology of Exercise Book
Author : Juleen R. Zierath,Michael J. Joyner,John A. Hawley
Publisher : Perspectives Cshl
Release : 2017-08-31
ISBN : 9781621822851
Language : En, Es, Fr & De

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Book Description :

Exercise training provokes widespread transformations in the human body, requiring coordinated changes in muscle composition, blood flow, neuronal and hormonal signaling, and metabolism. These changes enhance physical performance, improve mental health, and delay the onset of aging and disease. Understanding the molecular basis of these changes is therefore important for optimizing athletic ability and for developing drugs that elicit therapeutic effects. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine examines the biological basis of exercise from the molecular to the systemic levels. Contributors discuss how transcriptional regulation, cytokine and hormonal signaling, glucose metabolism, epigenetic modifications, microRNA profiles, and mitochondrial and ribosomal functions are altered in response to exercise training, leading to improved skeletal muscle, hippocampal, and cardiovascular function. Cross talk among the pathways underlying tissue-specific and systemic responses to exercise is also considered. The authors also discuss how the understanding of such molecular mechanisms may lead to the development of drugs that mitigate aging and disease. This volume will therefore serve as a vital reference for all involved in the fields of sports science and medicine, as well as anyone seeking to understand the molecular mechanisms by which exercise promotes whole-body health.

Cell to Cell Signalling

Cell to Cell Signalling Book
Author : A. Goldbeter
Publisher : Academic Press
Release : 2014-06-28
ISBN : 1483276791
Language : En, Es, Fr & De

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Book Description :

Cell to Cell Signalling: From Experiments to Theoretical Models is a collection of papers from a NATO Workshop conducted in Belgium in September 1988. The book discusses nerve cells and neural networks involved in signal transfers. The works of Hodgkin and Huxley presents a prototypic combination between experimental and theoretical approaches. The book discusses the coupling process found between secretory cells that modify their behavior. The text also analyzes morphogenesis and development, and then emphasizes the pattern formation found in Drosophila and in the amphibian embryo. The text also cite examples of immunological modeling that is related to the dynamics of immune networks based on idiotypic regulation. One paper analyzes the immune dynamism of HIV infection. The text notes that hormone signaling can be attributed as responsible for intercellular communication. Another paper examines how the dominant follicle in the ovarian cycle is selected, as well as the effectiveness of hormone secretion responsible for encoding the frequency of occurrence of periodic signals. The book also discusses heart signal sources such as cardiac dynamics and the response of periodically excited cardiac cells. The text can prove valuable for practioners in the field of neurology and cardiovascular medicine, and for researchers in molecular biology and molecular chemistry.

Biological and Medical Aspects of Electromagnetic Fields Fourth Edition

Biological and Medical Aspects of Electromagnetic Fields  Fourth Edition Book
Author : Ben Greenebaum,Frank Barnes
Publisher : CRC Press
Release : 2018-11-01
ISBN : 1351737724
Language : En, Es, Fr & De

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Book Description :

The two volumes of this new edition of the Handbook cover the basic biological, medical, physical, and electrical engineering principles. They also include experimental results concerning how electric and magnetic fields affect biological systems—both as potential hazards to health and potential tools for medical treatment and scientific research. They also include material on the relationship between the science and the regulatory processes concerning human exposure to the fields. Like its predecessors, this edition is intended to be useful as a reference book but also for introducing the reader to bioelectromagnetics or some of its aspects. FEATURES • New topics include coverage of electromagnetic effects in the terahertz region, effects on plants, and explicitly applying feedback concepts to the analysis of biological electromagnetic effects • Expanded coverage of electromagnetic brain stimulation, characterization and modeling of epithelial wounds, and recent lab experiments on at all frequencies • Section on background for setting standards and precautionary principle • Discussion of recent epidemiological, laboratory, and theoretical results; including: WHO IARC syntheses of epidemiological results on both high and low frequency fields, IITRI lab study of cancer in mice exposed to cell phone-like radiation, and other RF studies • All chapters updated by internationally acknowledged experts in the field

Breast Cancer

Breast Cancer Book
Author : Phuc Van Pham
Publisher : BoD – Books on Demand
Release : 2017-04-05
ISBN : 9535129996
Language : En, Es, Fr & De

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Book Description :

Breast Cancer - From Biology to Medicine thoroughly examines breast cancer from basic definitions, to cellular and molecular biology, to diagnosis and treatment. This book also has some additional focus on preclinical and clinical results in diagnosis and treatment of breast cancer. The book begins with introduction on epidemiology and pathophysiology of breast cancer in Section 1. In Section 2, the subsequent chapters introduce molecular and cellular biology of breast cancer with some particular signaling pathways, the gene expression, as well as the gene methylation and genomic imprinting, especially the existence of breast cancer stem cells. In Section 3, some new diagnostic methods and updated therapies from surgery, chemotherapy, hormone therapy, immunotherapy, radiotherapy, and some complementary therapies are discussed. This book provides a succinct yet comprehensive overview of breast cancer for advanced students, graduate students, and researchers as well as those working with breast cancer in a clinical setting.