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History Of Immunotoxicology

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History of Immunotoxicology

History of Immunotoxicology Book
Author : Jacques Descotes
Publisher : Academic Press
Release : 2017-10-01
ISBN : 0128098007
Language : En, Es, Fr & De

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Book Description :

History of Immunotoxicology offers the first book-length exploration of the development and importance of the field of immunotoxicology. Toxicology is evolving with the identification of new toxic hazards and the marketing of new chemicals. As preventive measures are implemented to reduce risks, including banning of chemicals or applications of one given chemical, current toxicologists may not be aware of the actual toxicity potential of chemicals when marketing or used in the past. Knowledge of what has occurred before can help to give context and understanding of current and future debates. Although immunotoxicology is one of the youngest areas of toxicology – its origin dates back to approximately half a century – a number of significant adverse effects and safety issues have been described, which deserve a historical perspective. History of Immunotoxicology describes the adverse health effects involving the immune system, hypersensitivity and autoimmunity. It also explores new avenues of research and immunotoxicity evaluation, as well as regulatory aspects of immunotoxicology, and the withdrawal/banning from the market of several approved drugs and chemicals due to their immunotoxic effects. Clinical manifestations of immunotoxicity, such as anaphylaxis, opportunistic infections, lymphomas, cytokine storm, and immunotherapy will be addressed. Finally, the book considers how the recent past can provide insights on the future practice of immunotoxicology. This book will be of interest to students and researchers in government, industry, and academia who have an interest in immunotoxicology. Examines the development of immunotoxicology Provides context to current debates about actual toxicity potential of chemicals Covers major developments and areas of immunotoxicology

Introduction To Immunotoxicology

Introduction To Immunotoxicology Book
Author : Jacques Descotes
Publisher : CRC Press
Release : 2003-09-02
ISBN : 0203362543
Language : En, Es, Fr & De

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Book Description :

This text provides a concise and comprehensive introduction to key immunotoxicological issues for all those interested in, but with no prior knowledge of, this area of toxicology. The first section explores the health consequences of immunotoxicity, namely the adverse effects related to chemically-induced immunosuppression and immunostimulation, hypersensitivity reactions and autoimmune diseases, with an overview of major immunotoxicants. The second part describes the latest methods used to detect and evaluate, preclinically and clinically, the unexpected immunotoxic effects of xenobiotics. Trends in implementing strategies and recent changes to the regulatory aspects are also considered. The third section examines possible future developments, including In Vitro methods, biomarkers of immunotixicity and risk assessment.

Principles and Methods of Immunotoxicology

Principles and Methods of Immunotoxicology Book
Author : Jacques Descotes
Publisher : Elsevier
Release : 2004-10-14
ISBN : 0080472990
Language : En, Es, Fr & De

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Book Description :

This is a review of clinical adverse effects on the human immune system that may occur following drug treatments and chemcical exposures. Current and prospective models and assays that can be used to predict these adverse effects in animal toxicity studies or in human beings are described.

Immunotoxicology and Immunopharmacology Third Edition

Immunotoxicology and Immunopharmacology  Third Edition Book
Author : Robert V. House,Robert Luebke,Ian Kimber
Publisher : CRC Press
Release : 2006-12-26
ISBN : 1420005448
Language : En, Es, Fr & De

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Book Description :

Continuing the tradition set by the first and second editions, each a bestseller in its own right, the third edition of Immunotoxicology and Immunopharmacology provides reviews of environmental agents, updated to reflect the latest information on how these agents influence immune system function and health. For the first time in the book's history, an entire section covers the phylogeny and ontogeny of the immune system, spanning levels of biological complexity from earthworms to marine mammals.

Investigative Immunotoxicology

Investigative Immunotoxicology Book
Author : Helen Tryphonas,Michel Fournier,Barry R. Blakley,Judit Smits,Pauline Brousseau
Publisher : CRC Press
Release : 2005-01-27
ISBN : 1134393997
Language : En, Es, Fr & De

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Book Description :

Investigative Immunotoxicology provides a critical evaluation of proposed experimental animal models and approaches, and discusses the contribution that immunotoxicity can make to the overall assessment of chemical-induced adverse health effects on humans and the ecosystem. Following a review of general concepts in immunotoxicology, the book discus

Immunotoxicity Testing

Immunotoxicity Testing Book
Author : Jamie C. DeWitt,Cheryl E. Rockwell,Christal C. Bowman
Publisher : Humana
Release : 2019-06-22
ISBN : 9781493993222
Language : En, Es, Fr & De

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Book Description :

This fully updated volume utilizes the expertise of scientists currently engaged in immunotoxicity testing to provide the reader with lab-ready procedures and the background information needed to identify effective testing approaches. Dedicated to identifying and describing exogenous agents that can modify immune function, uncovering modes and mechanisms of action for such agents, and translating data from the laboratory and from the clinic to better predict health risks as well as benefits to those who are exposed to immunomodulatory agents, immunotoxicity testing continues to be a vital field of study, and this collection highlights both the “tried and true” methods as well as alternative protocols that have been more recently developed. Written in the highly successful Methods in Molecular Biology format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Immunotoxicity Testing: Methods and Protocols, Second Edition serves as a valuable contribution to the continued evolution and the application of immunotoxicity testing.

Immunotoxicity Immune Dysfunction and Chronic Disease

Immunotoxicity  Immune Dysfunction  and Chronic Disease Book
Author : Rodney R. Dietert,Robert W. Luebke
Publisher : Springer Science & Business Media
Release : 2012-06-05
ISBN : 1617798126
Language : En, Es, Fr & De

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Book Description :

Chronic diseases are the leading cause of deaths worldwide and according to the World Economics Council and the Harvard School of Public Health, the cost of chronic diseases is expected to reach a staggering 48% of global gross domestic product by the year 2030. The urgency of the issue was demonstrated in 2011 when for only the second time in its existence, the U.N. General Assembly brought a health issue to the floor for consideration: chronic diseases. To date, most considerations of the issue have approached the topic from the vantage point that chronic diseases are a myriad of largely unconnected diseases and conditions arising in diverse tissues, organs and physiological systems. This book, Immunotoxicity, Immune Dysfuction, and Chronic Disease, deviates from that prior model. It considers the interconnectivity of chronic diseases with both environmental insult of the immune system and subsequent immune dysfunction and inflammatory dysregulation as the underlying basis for many, if not most, chronic diseases. This change in the perception of environment-immune linkages to chronic disease is significant and has immediate implications both for the prevention of disease as well as for the development of more effective therapeutic approaches. Rather than considering environmental factors and types of reported immune alterations (e.g., depressed humoral immunity) as is common in books involving immunotoxicity, the present book approaches the environment-immune-disease triad from the standpoint of the disease. Each chapter emphasizes one or more specific immune dysfunction-based chronic disease(s) or condition(s) (e.g., asthma, atherosclerosis, multiple sclerosis, lupus) and describes: 1) the suggested environmental risk factors, 2) the underlying immune dysfunction(s) associated with the disease and 3) the overall health consequences of the disease. This book is an early entry for a new Toxicology book series for Springer titled: Molecular and Integrative Toxicology (MaIT). The series will feature detailed research information, but in the context of a more integrative or holistic framework. As part of this framework, the chapters will contain a section on ”Key Points” as well as “Recommendations” where appropriate. The goal is to cover the most timely, state-of-the-art issues in toxicology as well as to ensure that the information is maximally accessible for research scientists, teachers, physicians and students. We are particularly grateful to the numerous chapter authors for providing comprehensive and expert disease-oriented contributions. We are also appreciative of their willingness to consider their material not as disparate pieces of what has become a major health crisis, but rather as key pieces in a network of apparently interconnected health challenges.

Infectious Disease Epidemiology

Infectious Disease Epidemiology Book
Author : Ibrahim Abubakar,Helen R. Stagg,Ted Cohen,Laura C. Rodrigues
Publisher : Oxford University Press
Release : 2016-04-07
ISBN : 0191030546
Language : En, Es, Fr & De

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Book Description :

Infectious Disease Epidemiology is a concise reference guide which provides trainees and practicing epidemiologists with the information that they need to understand the basic concepts necessary for working in this specialist area. Divided into two sections, part one comprehensively covers the basic principles and methods relevant to the study of infectious disease epidemiology. It is organised in order of increasing complexity, ranging from a general introduction to subjects such as mathematical modelling and sero-epidemiology. Part two examines key major infectious diseases that are of global significance. Grouped by their route of transmission for ease of reference, they include diseases that present a particular burden or a high potential for causing mortality. This practical guide will be essential reading for postgraduate students in infectious disease epidemiology, health protection trainees, and practicing epidemiologists.

Principles of Immunopharmacology

Principles of Immunopharmacology Book
Author : Franciscus Petrus Nijkamp,Michael J. Parnham
Publisher : Springer Science & Business Media
Release : 2005
ISBN : 9783764358044
Language : En, Es, Fr & De

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Book Description :

This updated 2nd edition provides a thorough grounding on the immune response, its diagnosis and its modification by drugs and chemicals. The first section of the book offers a basic introduction to immunology, updated to accommodate new immunological concepts. The second section on immunodiagnostics has been expanded to describe widely used molecular techniques and is followed by a systematic review of drugs affecting the immune system, revised to cover recent developments. The book concludes with a chapter on immunotoxicology. New aids to readers include a two-column format, glossaries of technical terms and appendix reference tables. The emphasis on illustrations is maintained from the first edition.

Information Resources in Toxicology

Information Resources in Toxicology Book
Author : P.J. Bert Hakkinen,Asish Mohapatra,Steven G. G. Gilbert
Publisher : Academic Press
Release : 2009-08-19
ISBN : 9780080920030
Language : En, Es, Fr & De

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Book Description :

This latest version of Information Resources in Toxicology (IRT) continues a tradition established in 1982 with the publication of the first edition in presenting an extensive itemization, review, and commentary on the information infrastructure of the field. This book is a unique wide-ranging, international, annotated bibliography and compendium of major resources in toxicology and allied fields such as environmental and occupational health, chemical safety, and risk assessment. Thoroughly updated, the current edition analyzes technological changes and is rife with online tools and links to Web sites. IRT-IV is highly structured, providing easy access to its information. Among the “hot topics covered are Disaster Preparedness and Management, Nanotechnology, Omics, the Precautionary Principle, Risk Assessment, and Biological, Chemical and Radioactive Terrorism and Warfare are among the designated. • International in scope, with contributions from over 30 countries • Numerous key references and relevant Web links • Concise narratives about toxicologic sub-disciplines • Valuable appendices such as the IUPAC Glossary of Terms in Toxicology • Authored by experts in their respective sub-disciplines within toxicology

Immunology

Immunology Book
Author : M. A. Hayat
Publisher : Academic Press
Release : 2017-10-31
ISBN : 012809897X
Language : En, Es, Fr & De

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Book Description :

Immunology, Volume 1: Immunotoxicology, Immunopathology, and Immunotherapy discusses the investment of time, effort and finance that go into making progress in preventing and/or curing serious diseases by using standard treatments (chemotherapy, radiotherapy, surgery, and hormone therapy). The use of these treatments is accompanied by unavoidable, devastating side effects. At the cost of being repetitious, it has to be emphasized that an improved understanding of the immune system, avoidance of unhealthy habits (e.g., smoking, intake of alcohol, perpetual stress, and lack of exercise) and early detection (using biomarkers) are the only three friends we have to at least delay the onset of serious diseases. Presents the most advanced information regarding the role of autophagy and immunity Introduces new, more effective therapeutic strategies in the development of targeted drugs and programmed cell death Edited work with chapters authored by leaders from around the globe – the broadest, most expert coverage available

Immunotoxicology Of Environmental And Occupational Metals

Immunotoxicology Of Environmental And Occupational Metals Book
Author : Judith T Zelicoff,Peter Thomas
Publisher : CRC Press
Release : 1998-02-20
ISBN : 0748403906
Language : En, Es, Fr & De

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Book Description :

Provides an overview of the effects of environmentally and occupationally important metals on the immune system and host defence. The fist ten chapters in the text focus on particular metals or groups of metals, including arsenic, beryllium, cadmium, chromium, lead, mercury, nickel and vanadium. Subsequent chapters examine the immunotoxicological effects of trace metals such as indium and platinum and essential metals such as iron, zinc and copper. The main emphasis is on the in vivo and in vitro effects of these metals on host immune responses in a variety of mammalian species including humans. Each chapter also briefly reviews the history, use, occurrence, biology and toxicology of the metals.

Principles and Practice of Toxicology in Public Health

Principles and Practice of Toxicology in Public Health Book
Author : Ira Richards
Publisher : Jones & Bartlett Learning
Release : 2008
ISBN : 0763738239
Language : En, Es, Fr & De

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Book Description :

In Five Sections, this reference Offers An Introduction To The Field, As WellAs The Basics Of Toxicology Principles, Chemical Toxicity, Ecotoxicology, AndToxicology Practice.

Information Resources in Toxicology

Information Resources in Toxicology Book
Author : Steve Gilbert,Asish Mohapatra,Sol Bobst,Antoinette Hayes,Sara T. Humes
Publisher : Academic Press
Release : 2020-05-16
ISBN : 0128137258
Language : En, Es, Fr & De

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Book Description :

This new fifth edition of Information Resources in Toxicology offers a consolidated entry portal for the study, research, and practice of toxicology. Both volumes represents a unique, wide-ranging, curated, international, annotated bibliography, and directory of major resources in toxicology and allied fields such as environmental and occupational health, chemical safety, and risk assessment. The editors and authors are among the leaders of the profession sharing their cumulative wisdom in toxicology’s subdisciplines. This edition keeps pace with the digital world in directing and linking readers to relevant websites and other online tools. Due to the increasing size of the hardcopy publication, the current edition has been divided into two volumes to make it easier to handle and consult. Volume 1: Background, Resources, and Tools, arranged in 5 parts, begins with chapters on the science of toxicology, its history, and informatics framework in Part 1. Part 2 continues with chapters organized by more specific subject such as cancer, clinical toxicology, genetic toxicology, etc. The categorization of chapters by resource format, for example, journals and newsletters, technical reports, organizations constitutes Part 3. Part 4 further considers toxicology’s presence via the Internet, databases, and software tools. Among the miscellaneous topics in the concluding Part 5 are laws and regulations, professional education, grants and funding, and patents. Volume 2: The Global Arena offers contributed chapters focusing on the toxicology contributions of over 40 countries, followed by a glossary of toxicological terms and an appendix of popular quotations related to the field. The book, offered in both print and electronic formats, is carefully structured, indexed, and cross-referenced to enable users to easily find answers to their questions or serendipitously locate useful knowledge they were not originally aware they needed. Among the many timely topics receiving increased emphasis are disaster preparedness, nanotechnology, -omics, risk assessment, societal implications such as ethics and the precautionary principle, climate change, and children’s environmental health. Introductory chapters provide a backdrop to the science of toxicology, its history, the origin and status of toxicoinformatics, and starting points for identifying resources. Offers an extensive array of chapters organized by subject, each highlighting resources such as journals, databases,organizations, and review articles. Includes chapters with an emphasis on format such as government reports, general interest publications, blogs, and audiovisuals. Explores recent internet trends, web-based databases, and software tools in a section on the online environment. Concludes with a miscellany of special topics such as laws and regulations, chemical hazard communication resources, careers and professional education, K-12 resources, funding, poison control centers, and patents. Paired with Volume Two, which focuses on global resources, this set offers the most comprehensive compendium of print, digital, and organizational resources in the toxicological sciences with over 120 chapters contributions by experts and leaders in the field.

Avian Immunology

Avian Immunology Book
Author : Karel A. Schat,Bernd Kaspers,Pete Kaiser
Publisher : Academic Press
Release : 2012-12-02
ISBN : 0123972728
Language : En, Es, Fr & De

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Book Description :

The second edition of Avian Immunology provides an up-to-date overview of the current knowledge of avian immunology. From the ontogeny of the avian immune system to practical application in vaccinology, the book encompasses all aspects of innate and adaptive immunity in chickens. In addition, chapters are devoted to the immunology of other commercially important species such as turkeys and ducks, and to ecoimmunology summarizing the knowledge of immune responses in free-living birds often in relation to reproductive success. The book contains a detailed description of the avian innate immune system, encompassing the mucosal, enteric, respiratory and reproductive systems. The diseases and disorders it covers include immunodepressive diseases and immune evasion, autoimmune diseases, and tumors of the immune system. Practical aspects of vaccination are examined as well. Extensive appendices summarize resources for scientists including cell lines, inbred chicken lines, cytokines, chemokines, and monoclonal antibodies. The world-wide importance of poultry protein for the human diet, as well as the threat of avian influenza pandemics like H5N1 and heavy reliance on vaccination to protect commercial flocks makes this book a vital resource. This book provides crucial information not only for poultry health professionals and avian biologists, but also for comparative and veterinary immunologists, graduate students and veterinary students with an interest in avian immunology. With contributions from 33 of the foremost international experts in the field, this book provides the most up-to-date review of avian immunology so far Contains a detailed description of the avian innate immune system reviewing constitutive barriers, chemical and cellular responses; it includes a comprehensive review of avian Toll-like receptors Contains a wide-ranging review of the "ecoimmunology" of free-living avian species, as applied to studies of population dynamics, and reviews methods and resources available for carrying out such research

Clinical Immunotoxicology

Clinical Immunotoxicology Book
Author : David S Newcombe
Publisher : CRC Press
Release : 1992-06-30
ISBN : 9781439805411
Language : En, Es, Fr & De

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Book Description :

This text is a comprehensive source of information on the toxic effects of environmental, industrial, and pharmacological agents on the human immune system. Focusing entirely on human immunotoxicology, without relying on animal models, the book explains the basic principles of immunotoxicology defines the mechanisms by which immunotoxins act, describes the clinical expression of immunotoxic disorders in the lung, skin, and other target organs, offers practical guidelines for early detection and control of host defense dysfunctions, and explores strategies for assessing the short- and long-term health effects of new and old chemicals and biologicals. The book includes extensive discussions on the role of low-dose, chronic immunosuppression in cancer, as well as on specific environmental and occupational immunotoxins and immunotoxic drugs used in hematology, anesthesiology, oncology and transplantation surgery.

Biologic Markers in Immunotoxicology

Biologic Markers in Immunotoxicology Book
Author : National Research Council,Division on Earth and Life Studies,Commission on Life Sciences,Board on Environmental Studies and Toxicology,Committee on Biologic Markers,Subcommittee on Immunotoxicology
Publisher : National Academies Press
Release : 1992-02-01
ISBN : 0309043891
Language : En, Es, Fr & De

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Book Description :

Are environmental pollutants threatening the human immune system? Researchers are rapidly approaching definitive answers to this question, with the aid of biologic markers--sophisticated assessment tools that could revolutionize detection and prevention of certain diseases. This volume, third in a series on biologic markers, focuses on the human immune system and its response to environmental toxicants. The authoring committee provides direction for continuing development of biologic markers, with strategies for applying markers to immunotoxicology in humans and recommended outlines for clinical and field studies. This comprehensive, up-to-date volume will be invaluable to specialists in toxicology and immunology and to biologists and investigators involved in the development of biologic markers.

Allergens and Respiratory Pollutants

Allergens and Respiratory Pollutants Book
Author : Marc A. Williams
Publisher : Elsevier
Release : 2011-07-18
ISBN : 1908818069
Language : En, Es, Fr & De

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Book Description :

Allergens and respiratory pollutants is a collection of 12 authoritative papers that draws upon the collective expertise of world leaders in the fields of innate immunity, immunotoxicology and pulmonary biology. The book critically explores the biological and immunological mechanisms that contribute to immune dysfunction on exposure to allergens and the susceptibility to infectious disease on exposure to ambient pollutants. The clinical relevance of exposure to ambient airborne xenobiotics is critically discussed and collectively, this book provides an educational forum that links the health effects of environmental exposures, immune dysfunction and inflammatory airways disease. Discusses recent advances in our understanding of cell-mediated innate immune mechanisms that occur during allergic inflammation and provides important timely coverage of diseases of concern and how such diseases are influenced by a dysfunctional immune system Provides useful information on linking environmental 'danger signals' that provoke immune dysfunction and exacerbation of existing disease Draws upon the collective expertise of an international college of leaders in the field, but also provides chapters that provide essential reference material

Principles and Practice of Toxicology in Public Health

Principles and Practice of Toxicology in Public Health Book
Author : Anonim
Publisher : Jones & Bartlett Publishers
Release : 2022-09-24
ISBN : 1449645275
Language : En, Es, Fr & De

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Book Description :

Download Principles and Practice of Toxicology in Public Health book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Schalm s Veterinary Hematology

Schalm s Veterinary Hematology Book
Author : Marjory B. Brooks,Kendal E. Harr,Davis M. Seelig,K. Jane Wardrop,Douglas J. Weiss
Publisher : John Wiley & Sons
Release : 2022-04-12
ISBN : 1119500508
Language : En, Es, Fr & De

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Book Description :

SCHALM’S VETERINARY HEMATOLOGY An updated guide to veterinary hematology with expanded coverage on a variety of topics The revised seventh edition of Schalm’s Veterinary Hematology is updated to provide a comprehensive review of all topics related to disorders of the blood in animals. Designed as a gold-standard reference, this text covers a wide range of species in both confined and free-range populations, reflects the most recent trends in hematology diagnostics, and discusses recent advances in traditional techniques. Edited and written by an international team of experts in the field, the book represents an accessible yet in-depth resource for information on veterinary hematology. The new edition includes a hemolymphatic tissue section that covers current understanding of basic science and the species-specific hematology section is further expanded from previous editions. New chapters address emerging topics in hematology, and existing chapters have been revised and rearranged to improve readability and simplify access to the material. This seventh edition: Updates the most complete reference on veterinary hematology across species Contains a new section on basic biology of hemolymphatic tissues Expands coverage of species-specific hematology Presents new and emerging topics in blood disorders and diagnostic techniques Features a reorganized contents list for an integrated, easy to use reference Written for veterinary clinical pathologists and residents, diagnostic laboratory staff, internists, and specialists, Schalm’s Veterinary Hematology is the most comprehensive and up-to-date reference on the topic.