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Histopathology Of Preclinical Toxicity Studies

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Histopathology of Preclinical Toxicity Studies

Histopathology of Preclinical Toxicity Studies Book
Author : Peter Greaves
Publisher : Academic Press
Release : 2011-11-22
ISBN : 0444538569
Language : En, Es, Fr & De

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Book Description :

Chapter 1: Introduction -- Chapter 2: Integumentary System -- -- Skin and subcutaneous tissue -- Chapter 3: Mammary Gland -- Chapter 4: Haemopoietic and Lymphatic Systems -- -- Blood/bone marrow -- -- Lymphoid system -- -- Lymph nodes -- -- Spleen -- -- Thymus -- -- Lymphoreticular neoplasms -- Chapter 5: Musculoskeletal System -- -- Bone -- -- Joints -- -- Skeletal muscle -- Chapter 6: Respiratory Tract -- -- Nose, nasal sinuses, nasopharynx and pharynx -- -- Larynx and trachea -- -- Bronchi and lungs -- Chapter 7: Cardiovascular System -- -- Heart and pericardium -- -- Systemic blood vessels -- -- Pulmonary blood vessels -- Chapter 8: Gastrointestinal tract -- -- Forestomach -- -- Stomach (glandular) -- -- Small intestine -- -- Large intestine -- Chapter 9: Liver and Pancreas -- -- Liver -- -- Bile ducts, biliary system -- -- Pancreas -- Chapter 10: Urinary System -- -- Kidney -- -- Urinary bladder -- Chapter 11: Male Genital Tract -- -- Prostate gland -- -- Epididymis -- -- Testis -- Chapter 12: Female Genital Tract -- -- Vagina -- -- Cervix -- -- Uterus -- -- Ovary -- Chapter 13: Endocrine System -- -- Pituitary gland -- -- Adrenal gland -- -- Thyroid gland -- -- Parathyroid gland -- Chapter 14: Nervous System and Special Sense Organs -- -- Brain -- -- Spinal cord, spinal nerve roots, peripheral nerves -- -- Eye -- -- Ear -- Subject index

Histopathology of Preclinical Toxicity Studies

Histopathology of Preclinical Toxicity Studies Book
Author : Peter Greaves
Publisher : Elsevier
Release : 2007-03-23
ISBN : 9780080471303
Language : En, Es, Fr & De

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Book Description :

This work covers effectively all aspects of drug-induced pathology that may be encountered within preclinical toxicity studies. It fills a gap in the pathology literature relating to the preclinical safety assessment of new medicines. It systematically describes, in one volume, both spontaneous and drug induced pathology on an organ by organ basis. Information relevant to understanding the nature of pathological changes in pre-clinical studies and assessment of their relevance to the clinical investigation of new drugs is also covered. Numerous colour photographs are included that highlight and embellish the histopathological features that are described. It also contains many pertinent references to both human and animal pathology forming an essential basis for the assessment of drug-induced pathology. NEW TO THE THIRD EDITION: * Covers drug induced pathology in preclinical (animal) studies and their relevance for patients or volunteers in clinical studies * General comments to each chapter about the relevance of pathological findings to humans * Provides essential information that can help decide the relevance of particular lesions for patients

Rat Histopathology

Rat Histopathology Book
Author : P. Greaves,J. M. Faccini
Publisher : Elsevier Science Limited
Release : 1992
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Hardbound. The need to update advances in histopathology that relate to toxicologic pathology has resulted in the stimulus to produce this second edition of Rat Histopathology. Consequently, each chapter has been expanded and updated, with more information on defining common and uncommon lesions, as well as on common strains of rat.This second edition follows the philosophy of the first and reflects the interests of the authors in human pathology, a useful inclusion because of the increasing evidence over recent years that many pathological processes in the rodent are quite similar to those occurring in man.This book will be of great value to toxicologists and pathologists as well as to medical and pharmaceutical libraries.

A Comprehensive Guide to Toxicology in Preclinical Drug Development

A Comprehensive Guide to Toxicology in Preclinical Drug Development Book
Author : Ali S. Faqi
Publisher : Academic Press
Release : 2012-11-16
ISBN : 0123878152
Language : En, Es, Fr & De

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Book Description :

A Comprehensive Guide to Toxicology in Preclinical Drug Development is a resource for toxicologists in industry and regulatory settings, as well as directors working in contract resource organizations, who need a thorough understanding of the drug development process. Incorporating real-life case studies and examples, the book is a practical guide that outlines day-to-day activities and experiences in preclinical toxicology. This multi-contributed reference provides a detailed picture of the complex and highly interrelated activities of preclinical toxicology in both small molecules and biologics. The book discusses discovery toxicology and the international guidelines for safety evaluation, and presents traditional and nontraditional toxicology models. Chapters cover development of vaccines, oncology drugs, botanic drugs, monoclonal antibodies, and more, as well as study development and personnel, the role of imaging in preclinical evaluation, and supporting materials for IND applications. By incorporating the latest research in this area and featuring practical scenarios, this reference is a complete and actionable guide to all aspects of preclinical drug testing. Chapters written by world-renowned contributors who are experts in their fields Includes the latest research in preclinical drug testing and international guidelines Covers preclinical toxicology in small molecules and biologics in one single source

Current Catalog

Current Catalog Book
Author : Anonim
Publisher : Unknown
Release : 1991
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

First multi-year cumulation covers six years: 1965-70.

A Toxicologist s Guide to Clinical Pathology in Animals

A Toxicologist s Guide to Clinical Pathology in Animals Book
Author : John E. Whalan
Publisher : Springer
Release : 2015-03-25
ISBN : 3319158538
Language : En, Es, Fr & De

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Book Description :

This guide provides an easy-to-use desk reference for diagnostic information on commonly used hematology, clinical chemistry and urinalysis parameters. Additional reference materials are provided as an aid in evaluating clinical pathology data. For many toxicologists, the evaluation of hematology, clinical chemistry and urinalysis data can be the most challenging aspect of animal toxicity studies. In a typical toxicity study, dozens of parameters are measured several times over the course of the study. There may be hundreds of data points, each of which needs to be considered. A Toxicologist’s Guide to Clinical Pathology in Animals will serve as an essential primer for toxicologists in training and in industry as well as for researchers and professionals in a veterinary practice or a laboratory.

Toxicologic Pathology

Toxicologic Pathology Book
Author : Pritam S. Sahota,James A. Popp,Jerry F. Hardisty,Chirukandath Gopinath
Publisher : CRC Press
Release : 2013-04-09
ISBN : 1439872104
Language : En, Es, Fr & De

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Book Description :

As drug development shifts over time to address unmet medical needs and more targeted therapies are developed, previously unseen pharmacological or off-target effects may occur in treatment. Designed to provide practical information for the bench toxicologic pathologist working in pharmaceutical drug research, Toxicologic Pathology: Nonclinical Safety Assessment presents a histopathologic description of lesions observed during drug development and discusses their implication in the drug development process. Divided into two sections, the book systematically assists pathologists in making a determination as to the origin and potential importance of a lesion and its relevance for assessing human risk. The first section includes eight "concept" chapters to orient pathologists in areas that are important for effective interaction with other pathologists as well as the many non-pathologists involved in drug development. The second section is made up of organ-based chapters, each including light microscopic and electron microscopic descriptions of pathological lesions, differential diagnoses, biological consequences, pathogenesis, mechanism of lesion formation, and the expected clinical pathology correlates. This volume presents critical information—both published and unpublished and gained through personal experience—to improve the quality of drug safety evaluation and to expedite and improve the efficiency of the process. This book is crafted to assist students, residents, and toxicologic pathologists in their early career phase by serving as a resource that can effectively be used as a ready reference next to the microscope. In addition, more experienced pathologists will find this volume to be invaluable during their assessments. The book is also a valuable reference for toxicologists to assist in understanding compound-related pathological findings and to provide background for working on a range of toxicological problems.

U S Government Research Development Reports

U S  Government Research   Development Reports Book
Author : Anonim
Publisher : Unknown
Release : 1968
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download U S Government Research Development Reports book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

U S Government Research and Development Reports

U  S  Government Research and Development Reports Book
Author : Anonim
Publisher : Unknown
Release : 1970-05
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download U S Government Research and Development Reports book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Technical Report Series

Technical Report Series Book
Author : Anonim
Publisher : Unknown
Release : 2011
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Technical Report Series book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Government Reports Announcements

Government Reports Announcements Book
Author : Anonim
Publisher : Unknown
Release : 1974
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Government Reports Announcements book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Preclinical Drug Development

Preclinical Drug Development Book
Author : Mark Rogge,David R. Taft
Publisher : CRC Press
Release : 2016-04-19
ISBN : 1420084739
Language : En, Es, Fr & De

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Book Description :

Preclinical Drug Development, Second Edition discusses the broad and complicated realm of preclinical drug development. Topics range from assessment of pharmacology and toxicology to industry trends and regulatory expectations to requirements that support clinical trials. Highlights of the Second Edition include: PharmacokineticsModeling and simula

Adverse Effects of Engineered Nanomaterials

Adverse Effects of Engineered Nanomaterials Book
Author : Bengt Fadeel,Antonio Pietroiusti,Anna A. Shvedova
Publisher : Academic Press
Release : 2012
ISBN : 0123869404
Language : En, Es, Fr & De

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Book Description :

An essential reference that discusses occupational exposure and the adverse health effects of engineered nanomaterials and highlights current and future biomedical applications of these nanomaterials in relation to nanosafety. Multi-authored book written by leading US and European experts on nanotoxicology and nanomedicine Discusses the health implications and a clinical translation of experimental data in this area Takes a schematic, non-exhaustive approach to summarize the most important research data in this field Includes a glossary, with a brief explanation of the term and with a reference to where the term or phrase has been used will be included within the book

Ansel s Pharmaceutical Dosage Forms and Drug Delivery Systems

Ansel s Pharmaceutical Dosage Forms and Drug Delivery Systems Book
Author : Loyd V. Allen,Nicholas G. Popovich,Howard C. Ansel
Publisher : Unknown
Release : 2011
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

"Thanks to its comprehensive coverage, clear explanations, and logical organization, Ansel's Pharmaceutical Dosage Forms and Drug Delivery Systems has been a core pharmaceutics text in the pharmacy curriculum for more than 40 years. As you progress through this thoroughly updated Ninth Edition, you'll master all the principles, practices, and technologies essential for the preparation of pharmaceutical dosage forms and drug delivery systems. The text's integrated approach will help you understand the interrelationships among pharmaceutical and biopharmaceutical principles, product design, formulation, manufacturing, compounding, and the clinical application of dosage forms for effective patient care." --Book Jacket.

A Comprehensive Guide to Toxicology in Nonclinical Drug Development

A Comprehensive Guide to Toxicology in Nonclinical Drug Development Book
Author : Ali S. Faqi
Publisher : Academic Press
Release : 2016-11-03
ISBN : 0128036214
Language : En, Es, Fr & De

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Book Description :

A Comprehensive Guide to Toxicology in Nonclinical Drug Development, Second Edition, is a valuable reference designed to provide a complete understanding of all aspects of nonclinical toxicology in the development of small molecules and biologics. This updated edition has been reorganized and expanded to include important topics such as stem cells in nonclinical toxicology, inhalation and dermal toxicology, pitfalls in drug development, biomarkers in toxicology, and more. Thoroughly updated to reflect the latest scientific advances and with increased coverage of international regulatory guidelines, this second edition is an essential and practical resource for all toxicologists involved in nonclinical testing in industry, academic, and regulatory settings. Provides unique content that is not always covered together in one comprehensive resource, including chapters on stem cells, abuse liability, biomarkers, inhalation toxicology, biostatistics, and more Updated with the latest international guidelines for nonclinical toxicology in both small and large molecules Incorporates practical examples in order to illustrate day-to-day activities and the expectations associated with working in nonclinical toxicology

Laboratory Animal Science

Laboratory Animal Science Book
Author : Anonim
Publisher : Unknown
Release : 1969
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Laboratory Animal Science book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Laboratory Animal Care

Laboratory Animal Care Book
Author : Anonim
Publisher : Unknown
Release : 1969
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Laboratory Animal Care book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Information Resources in Toxicology

Information Resources in Toxicology Book
Author : Philip Wexler
Publisher : Elsevier Publishing Company
Release : 1988
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

UNITED STATES RESOURCES; BOOK, SPECIAL DOCUMENTS, JOURNAL ARTICLES, JOURNALS, NEWSLETTERS, POPULAR WORKS, COMPUTERIZED INFORMATION SOURCES, ABSTRACTS, INDEXES, CURRENT AWARENESS, AUDIO VISUALS, INFORMATION HANDLING; LEGISLATION AND REGULATORY ISSUES; REGULATION OF CHEMICALS IN THE US, HAZARD COMMUNICATION COMPLIANCE; ORGANIZATIONS, EDUCATION, SCHOOLS, MUTAGENICITY TESTING LABORATORIES IN UNITED STATES; POISON CONTROL CENTERS; INTERNATIONAL RESOURCES.

Psychopharmacology and Women

Psychopharmacology and Women Book
Author : Margaret F. Jensvold,Uriel Halbreich,Jean A. Hamilton
Publisher : Amer Psychiatric Pub Incorporated
Release : 1996
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Brings together for the first time in one place current knowledge of sex differences in psychopharmacology. Features reviews of topics as well as recent advances and new theories and treatment.

Toxicologic Pathology

Toxicologic Pathology Book
Author : Pritam S. Sahota,James A. Popp,Jerry F. Hardisty,Chirukandath Gopinath,Page Bouchard
Publisher : CRC Press
Release : 2018-08-31
ISBN : 0429997450
Language : En, Es, Fr & De

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Book Description :

Following the success of the first edition, this book is designed to provide practical and timely information for toxicologic pathologists working in pharmaceutical drug discovery and development. The majority of the book (Organ Systems) will provide detailed descriptions of histopathological lesions observed in drug development. In addition, it will provide information to assist the pathologist in making determinations of the origin of lesions as well as its relevance to human risk. Toxicologic Pathology: Nonclinical Safety Assessment, Second Edition includes 2 new concept chapters. The first of the new chapters address approaches for the evaluation of unique therapeutic modalities such as cell therapies, gene therapies, and gene expression knockdown therapies. While these still represent new developing therapeutic approaches, there has been significant experience with the therapeutic modalities in the last 5 years. The second new chapter addresses the nonclinical safety assessment of medical devices, a topic of increasing importance that was not addressed in a unique chapter in the first edition. The other concept chapters have been updated and cover important topics including the overview of drug development; principles of nonclinical safety assessment; an introduction to toxicologic pathology; techniques used in toxicologic pathology, clinical pathology, toxicokinetics, and drug development toxicogenomics; and spontaneous lesions. The 13 organ system chapters provide the specifics related to pathologic characteristics, differential diagnosis, and interpretation of toxic responses in each organ system. These chapters are specifically important for the bench pathologist but also for the toxicologist who interacts with pathologists and function as study toxicologists and project team representatives in the drug development arena.