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High Throughput Bioanalytical Sample Preparation

High Throughput Bioanalytical Sample Preparation Book
Author : David Wells
Publisher : Elsevier Science Limited
Release : 2003-02-11
ISBN :
Language : En, Es, Fr & De

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Book Description :

High Throughput Bioanalytical Sample Preparation: Methods and Automation Strategies is an authoritative reference on the current state-of-the-art in sample preparation techniques for bioanalysis. This book focuses on high throughput (rapid productivity) techniques and describes exactly how to perform and automate these methodologies, including useful strategies for method development and optimization. A thorough review of the literature is included within each of these chapters describing high throughput sample preparation techniques: protein removal by precipitation; equilibrium dialysis and ultrafiltration; liquid-liquid extraction; solid-phase extraction; and various on-line techniques. The text begins with an introductory overview of the role of bioanalysis in pharmaceutical drug development. Fundamental understanding of the strategies for sample preparation is reinforced next, along with essential concepts in extraction chemistry. Several chapters introduce and discuss microplates, accessory products and automation devices. Particular strategies for efficient use of automation within a bioanalytical laboratory are also presented. The subject material then reviews protein precipitation, liquid-liquid extraction, solid-phase extraction and various on-line sample preparation approaches. The book concludes with information on recent advances in sample preparation, such as solid-phase extraction in a card format and higher density extraction plates. Important objectives that can be accomplished when the strategies presented in this book are followed include: improved efficiency in moving discovery compounds to preclinical status with robust analytical methods; return on investment in automation for sample preparation; and improved knowledge and expertise of laboratory staff. · Shows the reader exactly how to perform modern bioanalytical sample preparation techniques, complete with detailed strategies · Thorough literature review and summary of published information · Detailed discussion and examples of the method development process

High Throughput Bioanalytical Sample Preparation

High Throughput Bioanalytical Sample Preparation Book
Author : David A. Wells
Publisher : Elsevier
Release : 2017-06-01
ISBN : 044463584X
Language : En, Es, Fr & De

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Book Description :

High Throughput Bioanalytical Sample Preparation: Methods and Automation Strategies, Second Edition, is the go-to resource for industrial analytical chemists and others seeking the latest techniques for optimizing sample preparation in their everyday workflow. Outlining the latest preparation techniques from around the globe, this helpful guide provides answers to questions, including 'How do I automate a procedure?', 'How do I work to reduce matrix interferences?' 'Could I do this procedure online instead of in a manual batch?' 'What sorbent materials are available in the market?' 'How do I use a cation exchange resin?' 'What has been published on micro-sampling techniques?', and more. Featuring detailed coverage of the newer techniques that have emerged since the first edition was published, the book includes discussions on micro sampling and molecularly imprinted polymers, addresses the workflow pain points associated with extraction process efficiency, and outlines exactly how to optimize productivity through enhanced method development. Combining a step-by-step approach with a thorough explanation of the technology, this new edition features 40% new content and 60% revised content, accurately and thoroughly capturing the latest developments in research since the previous edition published in 2003. Offers broad coverage of all sample preparation methods and techniques, including the latest industry developments in bioanalysis Provides detailed ‘How-To’ approaches for each technique, making its applications immediately implementable Authored by an industry analytical chemist who has more than 30 years of experience in all facets of sample preparation, drug analysis, and more Features a thorough and inclusive bibliography of related publications in the field

High Throughput Analysis in the Pharmaceutical Industry

High Throughput Analysis in the Pharmaceutical Industry Book
Author : Perry G. Wang
Publisher : CRC Press
Release : 2008-08-20
ISBN : 1420059548
Language : En, Es, Fr & De

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Book Description :

The introduction of combinatorial chemistry technology has increased the amount of compounds generated in a year from 50 to 2000. Conventional analytical approaches simply cannot keep up. These circumstances have caused drug discovery to take on the shape of a bottleneck, like traffic through a toll booth. In order to break the bottleneck, a corres

Applied Biological Engineering

Applied Biological Engineering Book
Author : Ganesh R. Naik
Publisher : BoD – Books on Demand
Release : 2012-03-23
ISBN : 9535104128
Language : En, Es, Fr & De

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Book Description :

Biological engineering is a field of engineering in which the emphasis is on life and life-sustaining systems. Biological engineering is an emerging discipline that encompasses engineering theory and practice connected to and derived from the science of biology. The most important trend in biological engineering is the dynamic range of scales at which biotechnology is now able to integrate with biological processes. An explosion in micro/nanoscale technology is allowing the manufacture of nanoparticles for drug delivery into cells, miniaturized implantable microsensors for medical diagnostics, and micro-engineered robots for on-board tissue repairs. This book aims to provide an updated overview of the recent developments in biological engineering from diverse aspects and various applications in clinical and experimental research.

Sample Preparation in LC MS Bioanalysis

Sample Preparation in LC MS Bioanalysis Book
Author : Wenkui Li,Wenying Jian,Yunlin Fu
Publisher : John Wiley & Sons
Release : 2019-02-25
ISBN : 111927432X
Language : En, Es, Fr & De

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Book Description :

Revised and Expanded Handbook Provides Comprehensive Introduction and Complete Instruction for Sample Preparation in Vital Category of Bioanalysis Following in the footsteps of the previously published Handbook of LC-MS Bioanalysis, this book is a thorough and timely guide to all important sample preparation techniques used for quantitative Liquid Chromatography–Mass Spectrometry (LC-MS) bioanalysis of small and large molecules. LC-MS bioanalysis is a key element of pharmaceutical research and development, post-approval therapeutic drug monitoring, and many other studies used in human healthcare. While advances are continually being made in key aspects of LC-MS bioanalysis such as sensitivity and throughput, the value of research/study mentioned above is still heavily dependent on the availability of high-quality data, for which sample preparation plays the critical role. Thus, this text provides researchers in industry, academia, and regulatory agencies with detailed sample preparation techniques and step-by-step protocols on proper extraction of various analyte(s) of interest from biological samples for LC-MS quantification, in accordance with current health authority regulations and industry best practices. The three sections of the book with a total of 26 chapters cover topics that include: Current basic sample preparation techniques (e.g., protein precipitation, liquid-liquid extraction, solid-phase extraction, salting-out assisted liquid-liquid extraction, ultracentrifugation and ultrafiltration, microsampling, sample extraction via electromembranes) Sample preparation techniques for uncommon biological matrices (e.g., tissues, hair, skin, nails, bones, mononuclear cells, cerebrospinal fluid, aqueous humor) Crucial aspects of LC-MS bioanalytical method development (e.g., pre-analytical considerations, derivation strategies, stability, non-specific binding) in addition to sample preparation techniques for challenging molecules (e.g., lipids, peptides, proteins, oligonucleotides, antibody-drug conjugates) Sample Preparation in LC-MS Bioanalysis will prove a practical and highly valuable addition to the reference shelves of scientists and related professionals in a variety of fields, including pharmaceutical and biomedical research, mass spectrometry, and analytical chemistry, as well as practitioners in clinical pharmacology, toxicology, and therapeutic drug monitoring.

Regulated Bioanalytical Laboratories

Regulated Bioanalytical Laboratories Book
Author : Michael Zhou
Publisher : John Wiley & Sons
Release : 2011-03-31
ISBN : 9780470922804
Language : En, Es, Fr & De

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Book Description :

This book provides useful information for bioanalytical / analytical scientists, analysts, quality assurance managers, and all personnel in bioanalytical laboratories through all aspects of bioanalytical technical and regulatory perspectives within bioanalytical operations and processes. Readers learn how to develop and implement strategies for routine, non-routine, and standard bioanalytical methods and on the entire equipment hardware and software qualification process. The book also gives guidelines on qualification of certified standards and in-house reference material as well as on people qualification. Finally, it guides readers through stressless internal and third party laboratory audits and inspections. It takes account to most national and international regulations and quality and accreditation standards, along with corresponding interpretation and inspection guides. The author elaborates on highly comprehensive content, making it easy not only to learn the subject but also to quickly implement the recommendations.

A Handbook of Bioanalysis and Drug Metabolism

A Handbook of Bioanalysis and Drug Metabolism Book
Author : Gary Evans
Publisher : CRC Press
Release : 2004-03-29
ISBN : 9780203642535
Language : En, Es, Fr & De

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Book Description :

Recent years have seen a greater industrial emphasis in undergraduate and postgraduate courses in the pharmaceutical and chemical sciences. However, textbooks have been slow to adapt, leaving the field without a text/reference that is both instructional and practical in the industrial setting – until now. A Handbook of Bioanalysis and Drug Metabolismis a stimulating new text that examines the techniques, methodology, and theory of bioanalysis, pharmacokinetics, and metabolism from the perspective of scientists with extensive professional experience in drug discovery and development. These three areas of research help drug developers to optimize the active component within potential drugs thereby increasing their effectiveness, and to provide safety and efficacy information required by regulators when granting a drug license. Professionals with extensive experience in drug discovery and development as well as specialized knowledge of the individual topics contributed to each chapter to create a current and well-credentialed text. It covers topics such as high performance liquid chromatography, protein binding, pharmacokinetics and drug–drug interactions. The unique industrial perspective helps to reinforce theory and develop valuable analytical and interpreting skills. This text is an invaluable guide to students in courses such as pharmaceutical science, pharmacology, chemistry, physiology and toxicology, as well as professionals in the biotechnology industry.

Mass Spectrometry Handbook

Mass Spectrometry Handbook Book
Author : Mike S. Lee
Publisher : John Wiley & Sons
Release : 2012-04-16
ISBN : 1118180720
Language : En, Es, Fr & De

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Book Description :

Due to its enormous sensitivity and ease of use, mass spectrometry has grown into the analytical tool of choice in most industries and areas of research. This unique reference provides an extensive library of methods used in mass spectrometry, covering applications of mass spectrometry in fields as diverse as drug discovery, environmental science, forensic science, clinical analysis, polymers, oil composition, doping, cellular research, semiconductor, ceramics, metals and alloys, and homeland security. The book provides the reader with a protocol for the technique described (including sampling methods) and explains why to use a particular method and not others. Essential for MS specialists working in industrial, environmental, and clinical fields.

Principles and Practice of Bioanalysis

Principles and Practice of Bioanalysis Book
Author : Richard F. Venn
Publisher : CRC Press
Release : 2000-06-22
ISBN : 9780748408429
Language : En, Es, Fr & De

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Book Description :

Principles and Practice of Bioanalysis provides a guide to the methods available and the techniques currently used in this field. It provides up to the minute information and guidance on the methods and strategy used in developing and running ultra-trace analyses for drugs, metabolites and other substances. The authors writes in an informal and didactic style, offering a logical path through the problems of small molecule (bio)analysis and enables readers to choose appropriate methods of analysis for their needs. Principles and Practice of Bioanalysis provides an overview of analytical methods for analytical scientists within the pharmaceutical industry, research and development, the agrochemical industry, and scientists in the health service, biology and biochemistry. It also gives postgraduate students a useful reference for their research methods.

High Throughput Analysis for Food Safety

High Throughput Analysis for Food Safety Book
Author : Perry G. Wang,Mark F. Vitha,Jack F. Kay
Publisher : John Wiley & Sons
Release : 2014-08-07
ISBN : 1118907795
Language : En, Es, Fr & De

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Book Description :

This book focuses on high-throughput analyses for food safety. Because of the contributors domestic and international expertise from industry and government the book appeals to a wider audience. It includes the latest development in rapid screening, with a particular emphasis on the growing use and applicability of a variety of stand-alone mass spectrometry methods as well as using mass spectrometry in hyphenated techniques such as gas chromatograph mass spectrometry (GC-MS) and liquid chromatography mass spectrometry (LC-MS). Readers will be educated to the field of food safety and rapid testing in the most commonly used techniques. Divided into three parts (Basics of High Throughput Analyses, Mass Spectrometry in High Throughput Analyses, and International Food Safety Testing) this book covers many important aspects of high-throughput analyses for food safety.

Bioanalytical Separations

Bioanalytical Separations Book
Author : N.A
Publisher : Elsevier
Release : 2003-09-03
ISBN : 9780080527864
Language : En, Es, Fr & De

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Book Description :

Bioanalytical Separations is volume 4 of the multi-volume series, Handbook of Analytical Separations, providing reviews of analytical separation methods and techniques used for the determination of analytes across a whole range of applications. The theme for this volume is bioanalysis, in this case specifically meaning the analysis of drugs and their metabolites in biological fluids. - Discusses new developments in instrumentation and methods of analyzing drugs and their metabolites in biological fluids - Provides guidance to the different methods, their relative value to the user, and the advantages and pitfalls of their use - Future trends are identified, in terms of the potential impact of new technologies

Using Mass Spectrometry for Drug Metabolism Studies

Using Mass Spectrometry for Drug Metabolism Studies Book
Author : Walter A. Korfmacher
Publisher : CRC Press
Release : 2004-12-17
ISBN : 0203500040
Language : En, Es, Fr & De

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Book Description :

Mass spectrometry (MS) is fast becoming the premier tool for analyzing various drug metabolism samples in the early phases of drug discovery and research. Introducing the newer, more powerful MS equipment and exploring new applications for using them, this book provides a state-of-the-art look at this promising field. Using Mass Spectrometry for Drug Metabolism Studies is an excellent resource for professionals in the fields of mass spectrometry and drug metabolism. It offers current knowledge in stand–alone chapters that address specific topics thoroughly enough to be read independently, with notes and references to other chapters for further reading. The first eight chapters discuss current topics regarding the use of MS for analyzing various types of in vitro and in vivo drug metabolism samples and the final four chapters describe the latest MS technology and its uses. In each chapter, expert authors demonstrate how to apply MS to determine drug metabolism parameters. They also explain the different drug metabolism concepts and their importance. Although there are a few books currently on the market that address this topic, they are rapidly becoming out-of-date. This book gives drug researchers and pharmacokineticists the latest information available on this important technology.

Mass Spectrometry in Drug Metabolism and Disposition

Mass Spectrometry in Drug Metabolism and Disposition Book
Author : Mike S. Lee,Mingshe Zhu
Publisher : John Wiley & Sons
Release : 2011-03-16
ISBN : 9780470934692
Language : En, Es, Fr & De

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Book Description :

This book examines the background, industrial context, process, analytical methodology, and technology of metabolite identification. It emphasizes the applications of metabolite identification in drug research. While primarily a textbook, the book also functions as a comprehensive reference to those in the industry. The authors have worked closely together and combine complementary backgrounds to bring technical and cultural awareness to this very important endeavor while serving to address needs within academia and industry It also contains a variety of problem sets following specific sections in the text.

Handbook of LC MS Bioanalysis

Handbook of LC MS Bioanalysis Book
Author : Wenkui Li,Jie Zhang,Francis L. S. Tse
Publisher : John Wiley & Sons
Release : 2013-09-03
ISBN : 111867135X
Language : En, Es, Fr & De

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Book Description :

Consolidates the information LC-MS bioanalytical scientistsneed to analyze small molecules and macromolecules The field of bioanalysis has advanced rapidly, propelled by newapproaches for developing bioanalytical methods, new liquidchromatographic (LC) techniques, and new mass spectrometric (MS)instruments. Moreover, there are a host of guidelines andregulations designed to ensure the quality of bioanalyticalresults. Presenting the best practices, experimental protocols, and thelatest understanding of regulations, this book offers acomprehensive review of LC-MS bioanalysis of small molecules andmacromolecules. It not only addresses the needs of bioanalyticalscientists working on routine projects, but also explores advancedand emerging technologies such as high-resolution mass spectrometryand dried blood spot microsampling. Handbook of LC-MS Bioanalysis features contributions froman international team of leading bioanalytical scientists. Theircontributions reflect a review of the latest findings, practices,and regulations as well as their own firsthand analyticallaboratory experience. The book thoroughly examines: Fundamentals of LC-MS bioanalysis in drug discovery, drugdevelopment, and therapeutic drug monitoring The current understanding of regulations governing LC-MSbioanalysis Best practices and detailed technical instructions for LC-MSbioanalysis method development, validation, and stabilityassessment of analyte(s) of interest Experimental guidelines and protocols for quantitative LC-MSbioanalysis of challenging molecules, including pro-drugs, acylglucuronides, N-oxides, reactive compounds, and photosensitive andautooxidative compounds With its focus on current bioanalytical practice, Handbook ofLC-MS Bioanalysis enables bioanalytical scientists to developand validate robust LC-MS assay methods, all in compliance withcurrent regulations and standards.

Integrated Strategies for Drug Discovery Using Mass Spectrometry

Integrated Strategies for Drug Discovery Using Mass Spectrometry Book
Author : Mike S. Lee
Publisher : John Wiley & Sons
Release : 2005-09-02
ISBN : 0471721026
Language : En, Es, Fr & De

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Book Description :

New strategies and techniques for today's fast-paced discoveryprocess Today, the pressure is on for high-throughput approaches toaccelerate the generation, identification, and optimization ofmolecules with desirable drug properties. As traditional methods ofanalysis become antiquated, new analytical strategies andtechniques are necessary to meet sample throughput requirements andmanpower constraints. Among them, mass spectrometry has grown to bea front-line tool throughout drug discovery. Integrated Strategies for Drug Discovery Using Mass Spectrometryprovides a thorough review of current analytical approaches,industry practices, and strategies in drug discovery. The topicsrepresent current industry benchmarks in specific drug discoveryactivities that deal with proteomics, biomarker discovery,metabonomic approaches for toxicity screening, lead identification,compound libraries, quantitative bioanalytical support,biotransformation, reactive metabolite characterization, leadoptimization, pharmaceutical property profiling, sample preparationstrategies, and automation. THIS BOOK: * Clearly explains how drug discovery and mass spectrometry areinterconnected * Discusses the uses and limitations of various types of massspectrometry in various aspects of drug discovery * Prominently features analytical applications that requiretrace-mixture analysis * Provides industry applications and real-world examples * Shares historical background information on various techniques toaid in the understanding of how and why new methods are now beingemployed to analyze samples

Pesticides Advances in Research and Application 2012 Edition

Pesticides   Advances in Research and Application  2012 Edition Book
Author : N.A
Publisher : ScholarlyEditions
Release : 2012-12-26
ISBN : 1464991588
Language : En, Es, Fr & De

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Book Description :

Pesticides—Advances in Research and Application: 2012 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Pesticides. The editors have built Pesticides—Advances in Research and Application: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Pesticides in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Pesticides—Advances in Research and Application: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Antisense Drug Technology

Antisense Drug Technology Book
Author : Stanley T. Crooke
Publisher : CRC Press
Release : 2001-09-14
ISBN : 9780824705664
Language : En, Es, Fr & De

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Book Description :

This state-of-the-art reference provides comprehensive coverage of the development of antisense oligonucleotides to inhibit cancer cells as well as those involved in infectious, inflammatory, and immune-mediated diseases-highlighting new tools and technologies in medicinal chemistry, RNA biochemistry, and molecular and cellular biology to produce new therapeutic compounds. Presents previously unpublished data on the use of antisense technology to dissect pharmacological processes and confirm the roles of various genes! Showcasing the benefits of antisense drug use, including reduced toxicity and earlier disease detection, Antisense Drug Technology discusses novel formulations of antisense drugs practical methods to design effective isotype selective inhibitors molecular mechanisms of antisense drugs mRNA as a current biological template modern postreceptor binding mechanisms and more! With contributions by over 60 seasoned experts in the field and containing more than 3000 helpful references, tables, drawings, and photographs, Antisense Drug Technology is an illuminating source for organic, medicinal, and pharmaceutical chemists; biochemists; geneticists; hematologists; oncologists; molecular and cell biologists; virologists; immunologists; and medical school and graduate students in these disciplines.

Technologies for Smart Sensors and Sensor Fusion

Technologies for Smart Sensors and Sensor Fusion Book
Author : Kevin Yallup,Krzysztof Iniewski
Publisher : CRC Press
Release : 2014-04-14
ISBN : 1466595515
Language : En, Es, Fr & De

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Book Description :

Exciting new developments are enabling sensors to go beyond the realm of simple sensing of movement or capture of images to deliver information such as location in a built environment, the sense of touch, and the presence of chemicals. These sensors unlock the potential for smarter systems, allowing machines to interact with the world around them in more intelligent and sophisticated ways. Featuring contributions from authors working at the leading edge of sensor technology, Technologies for Smart Sensors and Sensor Fusion showcases the latest advancements in sensors with biotechnology, medical science, chemical detection, environmental monitoring, automotive, and industrial applications. This valuable reference describes the increasingly varied number of sensors that can be integrated into arrays, and examines the growing availability and computational power of communication devices that support the algorithms needed to reduce the raw sensor data from multiple sensors and convert it into the information needed by the sensor array to enable rapid transmission of the results to the required point. Using both SI and US units, the text: Provides a fundamental and analytical understanding of the underlying technology for smart sensors Discusses groundbreaking software and sensor systems as well as key issues surrounding sensor fusion Exemplifies the richness and diversity of development work in the world of smart sensors and sensor fusion Offering fresh insight into the sensors of the future, Technologies for Smart Sensors and Sensor Fusion not only exposes readers to trends but also inspires innovation in smart sensor and sensor system development.

High Throughput Screening

High Throughput Screening Book
Author : John P. Devlin
Publisher : CRC Press
Release : 1997-05-06
ISBN : 9780824700676
Language : En, Es, Fr & De

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Book Description :

Furnishing the latest interdisciplinary information on the most important and frequently the only investigational system available for discovery programs that address the effects of small molecules on newly discovered enzyme and receptor targets emanating from molecular biology, this timely resource facilitates the transition from classical to high throughput screening (HTS) systems and provides a solid foundation for the implementation and development of HTS in bio-based industries and associated academic environments.

Mass Spectrometry An Issue of Clinics in Laboratory Medicine E Book

Mass Spectrometry  An Issue of Clinics in Laboratory Medicine   E Book Book
Author : Nigel Clarke,Andrew N. Hoofnagle
Publisher : Elsevier Health Sciences
Release : 2011-10-03
ISBN : 1455712019
Language : En, Es, Fr & De

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Book Description :

This issue of Clinics in Laboratory Medicine, Guest Edited by Nigel Clarke, MD, and Andrew Hoofnagle, MD, will focus on Mass Spectrometry, with topics including: Proteins; Peptides; Small Molecules: Toxicology; Small Molecules: Diagnostics; and Regulatory Considerations.