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Her2 Positive Breast Cancer

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HER2 Positive Breast Cancer

HER2 Positive Breast Cancer Book
Author : Sara Hurvitz,Kelly McCann
Publisher : Elsevier Health Sciences
Release : 2018-07-26
ISBN : 0323581234
Language : En, Es, Fr & De

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Book Description :

Get a quick, expert overview of clinically-focused topics and guidelines that are relevant to testing for HER2, which contributes to approximately 25% of breast cancers today. This concise resource by Drs. Sara Hurvitz, and Kelly McCann consolidates today’s available information on this growing topic into one convenient resource, making it an ideal, easy-to-digest reference for practicing and trainee oncologists.

HER2 Positive Breast Cancer

HER2 Positive Breast Cancer Book
Author : Sara Hurvitz,Kelly McCann
Publisher : Elsevier
Release : 2018-08
ISBN : 9780323581226
Language : En, Es, Fr & De

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Book Description :

Get a quick, expert overview of clinically-focused topics and guidelines that are relevant to testing for HER2, which contributes to approximately 25% of breast cancers today. This concise resource by Drs. Sara Hurvitz, and Kelly McCann consolidates today's available information on this growing topic into one convenient resource, making it an ideal, easy-to-digest reference for practicing and trainee oncologists. Covers the diagnosis, treatments and targeted therapies, and management of breast cancers that are HER2-positive. Contains sections on background and testing, advanced disease, therapeutics, and toxicity considerations. Includes a timely section on innovative future therapies.

Abeloff s Clinical Oncology E Book

Abeloff s Clinical Oncology E Book Book
Author : Martin D. Abeloff,James O. Armitage,John E. Niederhuber,Michael B. Kastan,W. Gillies McKenna
Publisher : Elsevier Health Sciences
Release : 2008-06-30
ISBN : 1437720560
Language : En, Es, Fr & De

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Book Description :

Carrying on the tradition established by its founding editor, the late Dr. Martin Abeloff, the 4th Edition of this respected reference synthesizes all of the latest oncology knowledge in one practical, clinically focused, easy-to-use volume. It incorporates basic science, pathology, diagnosis, management, outcomes, rehabilitation, and prevention – all in one convenient resource – equipping you to overcome your toughest clinical challenges. What's more, you can access the complete contents of this Expert Consult title online, and tap into its unparalleled guidance wherever and whenever you need it most! Equips you to select the most appropriate tests and imaging studies for diagnosing and staging each type of cancer, and manage your patients most effectively using all of the latest techniques and approaches. Explores all of the latest scientific discoveries' implications for cancer diagnosis and management. Employs a multidisciplinary approach - with contributions from pathologists, radiation oncologists, medical oncologists, and surgical oncologists - for well-rounded perspectives on the problems you face. Offers a user-friendly layout with a consistent chapter format • summary boxes • a full-color design • and more than 1,445 illustrations (1,200 in full color), to make reference easy and efficient. Offers access to the book's complete contents online – fully searchable – from anyplace with an Internet connection. Presents discussions on cutting-edge new topics including nanotechnology, functional imaging, signal transduction inhibitors, hormone modulators, complications of transplantation, and much more. Includes an expanded color art program that highlights key points, illustrates relevant science and clinical problems, and enhances your understanding of complex concepts.

Central Nervous System Metastases

Central Nervous System Metastases Book
Author : Manmeet Ahluwalia,Philippe Metellus,Riccardo Soffietti
Publisher : Springer Nature
Release : 2019-11-05
ISBN : 3030234177
Language : En, Es, Fr & De

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Book Description :

This book provides a comprehensive overview of brain metastases, from the molecular biology aspects to therapeutic management and perspectives. Due to the increasing incidence of these tumors and the urgent need to effectively control brain metastatic diseases in these patients, new therapeutic strategies have emerged in recent years. The volume discusses all these innovative approaches combined with new surgical techniques (fluorescence, functional mapping, integrated navigation), novel radiation therapy techniques (stereotactic radiosurgery) and new systemic treatment approaches such as targeted- and immunotherapy. These combination strategies represent a new therapeutic model in brain metastatic patients in which each medical practitioner (neurosurgeon, neurologist, medical oncologist, radiation oncologist) plays a pivotal role in defining the optimal treatment in a multidisciplinary approach. Written by recognized experts in the field, this book is a valuable tool for neurosurgeons, neuro-oncologists, neuroradiologists, medical oncologists, radiation oncologists, cognitive therapists, basic scientists and students working in the area of brain tumors.

Targeted Therapies in Breast Cancer

Targeted Therapies in Breast Cancer Book
Author : George W. Sledge, Jr.,Jose Baselga
Publisher : Unknown
Release : 2013-04-15
ISBN : 9781846920660
Language : En, Es, Fr & De

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Book Description :

This new volume updates the reader on selected areas of targeted therapy in breast cancer, with special emphasis on chemoprevention strategies, drug resistance, biomarkers, combination chemotherapy, angiogenesis inhibition and pharmacogenomics in the context of clinical efficacy. This selected review of targeted therapies will guide the reader on effective treatment as part of an integrated programme of patient management.

Her 2

Her 2 Book
Author : Robert Bazell
Publisher : Random House
Release : 2011-04-27
ISBN : 0307764982
Language : En, Es, Fr & De

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Book Description :

Two years after she underwent a mastectomy and chemotherapy, Barbara Bradfield's aggressive breast cancer had recurred and spread to her lungs. The outlook was grim. Then she took part in Genentech's clinical trials for a new drug. Five years later she remains cancer-free. Her-2 is the biography of Herceptin, the drug that provoked dramatic responses in Barbara Bradfield and other women in the trials and that offers promise for hundreds of thousands of breast cancer patients. Unlike chemotherapy or radiation, Herceptin has no disabling side effects. It works by inactivating Her-2/neu--a protein that makes cancer cells grow especially quickly-- produced by a gene found in 25 to 30 percent of all breast tumors. Herceptin caused some patients' cancers to disappear completely; in others, it slowed the progression of the disease and gave the women months or years they wouldn't otherwise have had. Herceptin is the first treatment targeted at a gene defect that gives rise to cancer. It marks the beginning of a new era of treatment for all kinds of cancers. Robert Bazell presents a riveting account of how Herceptin was born. Her-2 is a story of dramatic discoveries and strong personalities, showing the combination of scientific investigation, money, politics, ego, corporate decisions, patient activism, and luck involved in moving this groundbreaking drug from the lab to a patient's bedside. Bazell's deft portraits introduce us to the remarkable people instrumental in Herceptin's history, including Dr. Dennis Slamon, the driven UCLA oncologist who played the primary role in developing the treatment; Lily Tartikoff, wife of television executive Brandon Tartikoff, who tapped into Hollywood money and glamour to help fund Slamon's research; and Marti Nelson, who inspired the activists who lobbied for a "compassionate use" program that would allow women outside the clinical trials to have access to the limited supplies of Herceptin prior to FDA approval of the drug. And throughout there are the stories of the heroic women with advanced breast cancer who volunteered for the trials, risking what time they had left on an unproven treatment. Meticulously researched, written with clarity and compassion, Her-2 is masterly reporting on cutting-edge science.

Take Control of Your Cancer Risk

Take Control of Your Cancer Risk Book
Author : John Whyte, MD, MPH
Publisher : Harper Horizon
Release : 2021-10-05
ISBN : 0785240411
Language : En, Es, Fr & De

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Book Description :

Something everyone has the power to do is reduce your cancer risk, and this book will show you just how easy it is to do it. Each year, over a million people in the United States alone hear the words no one ever wants to hear: You have cancer. But what if there was a way for fewer people to hear these words? One of the biggest myths regarding cancer is that it’s mostly genetic - meaning that you have no control over whether you get it. While genetics do have an impact, the truth is that your lifestyle and environment play the major role. Physician and Chief Medical Offer of WebMD John Whyte, MD, MPH, shares straightforward information and equips you with strategies to help you on a journey to better health. In Take Control of Your Cancer Risk, Dr. Whyte provides helpful tips including: assessing your cancer risk knowing which screenings you need, and when learning the role food, exercise, and sleep play understanding the relationship between stress and cancer Take Control of Your Cancer Risk is filled with practical advice that empowers you to really take control of our health.

Sentinel Lymph Node Biopsy

Sentinel Lymph Node Biopsy Book
Author : Hiram S. Cody
Publisher : CRC Press
Release : 2001-11-08
ISBN : 9781841840345
Language : En, Es, Fr & De

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Book Description :

An intuitive, ingenious and powerful technique, sentinel lymph node biopsy has entered clinical practice with astonishing rapidity and now represents a new standard of care for melanoma and breast cancer patients, while showing great promise for the treatment of urologic, colorectal, gynecologic, and head and neck cancers. This text, written by international experts in the technique, provides a clear and comprehensive guide, presenting a detailed overview and discussing the various mapping techniques available and how these are applied in a number of leading institutions. This essential resource for surgical onocologists, pathologists, and specialists in nuclear medicine will also provide key information for those planning to start a sentinel lymph node program.

Neo adjuvant Chemotherapy

Neo adjuvant Chemotherapy Book
Author : Claude Jacquillat,Marise Weil,David Khayat,Institut national de la santé et de la recherche médicale (France)
Publisher : John Libbey Eurotext
Release : 1988
ISBN : 9780861961504
Language : En, Es, Fr & De

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Book Description :

This book presents the Proceedings of the Second International Congress on Neo-Adjuvant Chemotherapy which took place on 19 to 21 February 1988 in Paris.

Optimising the Role of Herceptin in Breast Cancer

Optimising the Role of Herceptin in Breast Cancer Book
Author : David Khayat
Publisher : S Karger Ag
Release : 2001-01-01
ISBN : 9783805573276
Language : En, Es, Fr & De

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Book Description :

The humanised monoclonal antibody Herceptin® targets human epidermal growth factor receptor-2 (HER2) positive cells, i.e. cells in which HER2 is overexpressed, a feature associated with many tumour characteristics. Approximately 20-30% of breast cancers are HER2 positive and are known to be particularly aggressive. Thus, HER2-positive clinical trials of Herceptin® have clearly demonstrated that it provides significant clinical benefit in HER2-positive metastatic dis-ease, most importantly increased survival when administered first line in combination with chemotherapy. The articles in this supplement review our knowledge of the activity of HER2 and how to test for HER2 status, and describe the clinical trials of Herceptin® that have been performed today. In conclusion, future research with this novel agent is likely to change the management of cancer patients and further improve the efficacy of therapy.

The Breast Cancer Survival Manual Fifth Edition

The Breast Cancer Survival Manual  Fifth Edition Book
Author : John Link, M.D.
Publisher : Holt Paperbacks
Release : 2012-08-07
ISBN : 1429961481
Language : En, Es, Fr & De

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Book Description :

The updated edition of the essential resource for the 250,000 women diagnosed with breast cancer each year Breast cancer is the leading cause of death in women from thirty-five to fifty-four years of age, and few things are as terrifying and confusing as a diagnosis of this disease. The fifth edition of The Breast Cancer Survival Manual is a concise, information-packed guide that is newly revised to contain all of the latest findings to help the woman facing treatment feel informed and empowered. John Link, M.D., a pioneer developer of Breastlink Medical Group in Southern California includes the most current medical advice on • Tamoxifen, Herceptin, and other chemotherapy options • The growing importance of HER2 oncogene testing • Clinical research trials under way that could broaden treatment options • The role of preventive drugs and prophylactic mastectomy for those with high genetic risk • Sentinel lymph node sampling, a method of local control soon to become standard Of course, all of the basic information included in the previous editions—the nature and biology of breast cancer, choosing a treatment team, managing side effects, and optimizing medication—are here as well, making this the best book of its kind on the market.

Breast Cancer

Breast Cancer Book
Author : Adnan Aydiner,Abdullah Igci,Atilla Soran
Publisher : Springer
Release : 2018-10-29
ISBN : 3319969471
Language : En, Es, Fr & De

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Book Description :

This book is a practical guide to the management of patients with breast malignancies. It serves as a quick reference book that gives the most up-to-date routine practical management strategies of breast cancer. Written and edited by leading experts, this handbook focuses on the application of conventional and novel treatment strategies to the care of patients with malignant breast disease and all stages of breast cancer. The chapters provide evidence-based treatment strategies for all patient subsets. Surgical, radiation, and medical treatment options are all discussed for each stage of breast cancer. It also includes the definitions of statistical terminologies and their usage in clinical practice and research. This is a comprehensive yet concise resource for residents, fellows, and early-career practitioners.

100 Questions Answers About Advanced Metastatic Breast Cancer

100 Questions   Answers About Advanced   Metastatic Breast Cancer Book
Author : Lillie D. Shockney,Gary R. Shapiro
Publisher : Jones & Bartlett Publishers
Release : 2011-06
ISBN : 1449643361
Language : En, Es, Fr & De

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Book Description :

EMPOWER YOURSELF! Whether you're a newly diagnosed patient, survivor, or loved one of someone suffering from advanced breast cancer, 100 Questions & Answers About Advanced and Metastatic Breast Cancer, Second Edition offers essential and practical guidance. Providing both doctor and patient perspectives, this updated and revised edition offers authoritative answers to the most commonly asked questions about advanced and metastatic breast cancer including diagnosis, treatment, post-treatment quality of life, alternative medicine, targeted therapy, and coping strategies. Written by experts from Johns Hopkins University and Medical Center, this new edition is an invaluable resource for anyone coping with the physical and emotional turmoil of this disease.

Preoperative Neoadjuvant Chemotherapy

Preoperative  Neoadjuvant  Chemotherapy Book
Author : Joseph Ragaz,Pierre R. Band,James H. Goldie
Publisher : Springer Science & Business Media
Release : 2012-12-06
ISBN : 3642826717
Language : En, Es, Fr & De

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Book Description :

Despite recent advances in adjuvant therapies of cancer, the regi mens of postoperative adjuvant chemotherapy treatment which are presently available fail to cure the majority of cancer patients. Pre operative (neoadjuvant) chemotherapy represents a new approach in drug scheduling, based on sound theoretical, pharmacokinetic, and experimental principles. The preoperative timing of chemotherapy before definitive sur gery is not a minor change in the therapy of cancer. To be successful, large numbers of practitioners and their patients must participate. Substantial alterations of many aspects of the present management of cancer will have to follow. Therefore, before such therapy can be fully and routinely implemented, results of the novel treatment and its rationale have to be carefully evaluated. In preoperative treatment, other features will likely gain impor tance. For the first time, clinicians have a chance to follow the in vivo response of the tumor exposed to preoperative chemotherapy. The subsequent histological assessment of the tumor sample may likely become an important prognostic guide, permitting more re fined individual approaches to the planning of postoperative adju vant treatment. The value of such a treatment strategy can already be appreciated in the clinical setting, as seen from the therapy of osteosarcoma. Furthermore, preoperative chemotherapy might render previously inoperable tumors operable and hence resectable with a curative intention. The preoperative reduction of tumor bulk may also effectively decrease the need for more radical operations, permitting a more uniform adoption of conservative surgery.

HER2 Inhibitors Advances in Research and Application 2013 Edition

HER2 Inhibitors   Advances in Research and Application  2013 Edition Book
Author : Anonim
Publisher : ScholarlyEditions
Release : 2013-06-21
ISBN : 1481676237
Language : En, Es, Fr & De

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Book Description :

HER2 Inhibitors—Advances in Research and Application: 2013 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about ZZZAdditional Research in a concise format. The editors have built HER2 Inhibitors—Advances in Research and Application: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about ZZZAdditional Research in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of HER2 Inhibitors—Advances in Research and Application: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

New Approaches to Classification and Diagnostic Prediction of Breast Cancers

New Approaches to Classification and Diagnostic Prediction of Breast Cancers Book
Author : Aleix Prat,Mothaffar Rimawi
Publisher : Frontiers Media SA
Release : 2020-06-16
ISBN : 2889637964
Language : En, Es, Fr & De

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Book Description :

Despite many years of translational research in breast cancer, very few new biomarkers have been implemented for clinical use beyond estrogen receptor, progesterone receptor, and HER2. The main reason is that many promising biomarkers are clinically validated but lack analytical and clinical utility. One explanation is that proper validation of the predictive ability of the biomarker in independent datasets, and with a pre-planned statistical analysis, is not always performed. Thus, there is a need to identify new biomarkers or new ways to subclassify breast cancer patients that are reproducible and easy to implement in the clinical setting but, more importantly, that improve patient’s outcomes.

Targeted Therapies in Breast Cancer

Targeted Therapies in Breast Cancer Book
Author : Harold J. Burstein
Publisher : Oxford American Pocket Notes
Release : 2011
ISBN : 0199735670
Language : En, Es, Fr & De

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Book Description :

The development of monoclonal antibodies and other inhibitors of specific molecules, fully utilizing the insights learned from molecular techniques such as comparative microarrays and protein expression patterns, has led to the development and FDA approval of several agents for the treatment of breast cancer, such as trastuzamab (Herceptin, targeting HER-2 positive tumors) and lapatinib (Tykerb, targeting tumors with mutated/overexpressed EGFR 1 and 2). Other agents specifically targeting the estrogen receptor, the aromatose pathway and microtubule dynamics, fulvestrant (Faslodex, targeting the ER specifically in breast cancer cells), and letrozole (Femara, targeting the aromatose pathway), raloxifene (Evista, a selective estrogen receptor modulator), ixabepilone (Ixempra, a ?-tubulin inhibitor) have also been approved for various stages and specific settings in breast cancer treatment. The current challenges in the field include further targeting of these agents as part of specific strategies for each patient (biomarker testing, pharmacogenetics, etc.), as well as follow-up and management of adverse events. Part of the Oxford American Pocket Notes series, this volume provides clinicians with the ultra-concise, evidence-based, current information and insight on implementing the latest treatment strategies, including targeted agents, into clinical practice. This portable volume is intended to provide quick, easily accessible guidance for the practicing oncologist, oncology care staff (including nurses and PAs) as well as the primary care practitioner, on the mechanism of action, dosing and administration and adverse effects of the approved targeted agents.

Adjuvant Therapy for Breast Cancer

Adjuvant Therapy for Breast Cancer Book
Author : Monica Castiglione,Martine J. Piccart
Publisher : Springer Science & Business Media
Release : 2009-07-11
ISBN : 9780387751153
Language : En, Es, Fr & De

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Book Description :

Adjuvant treatment is administered prior to or as follow up to surgical procedures for breast cancer. Proven success in using medical therapies allowing for breast conserving procedures or reducing risk of occurrence. Although there has been much progress towards a cure, including the introduction of new targeted therapies, metastasizing cancer remains highly incurable.

Biomarkers in Breast Cancer

Biomarkers in Breast Cancer Book
Author : Giampietro Gasparini,Daniel F. Hayes
Publisher : Springer Science & Business Media
Release : 2008-01-17
ISBN : 159259915X
Language : En, Es, Fr & De

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Book Description :

Expert laboratory and clinical researchers from around the world review how to design and evaluate studies of tumor markers and examine their use in breast cancer patients. The authors cover both the major advances in sophisticated molecular methods and the state-of-the-art in conventional prognostic and predictive indicators. Among the topics discussed are the relevance of rigorous study design and guidelines for the validation studies of new biomarkers, gene expression profiling by tissue microarrays, adjuvant systemic therapy, and the use of estrogen, progesterone, and epidermal growth factor receptors as both prognostic and predictive indicators. Highlights include the evaluation of HER2 and EGFR family members, of p53, and of UPA/PAI-1; the detection of rare cells in blood and marrow; and the detection and analysis of soluble, circulating markers.

Nuclear Oncology

Nuclear Oncology Book
Author : Cumali Aktolun,W. Newlon Tauxe
Publisher : Springer Science & Business Media
Release : 2012-12-06
ISBN : 3642586430
Language : En, Es, Fr & De

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Book Description :

Nuclear Oncology describes the use of radionuclides in the diagnosis and management of malignant tumors. Both in vivo and in vitro techniques are included. The book was written by an international panel of authors, most, if not all, of whom are the pioneers of the techniques described. Their chapters reflect the universal views in the field of nuclear medicine and oncology. Clinical aspects and technical details are presented for both standard and new nuclear oncological techniques, including breast scintigraphy, receptor imaging, monoclonal antibodies and positron emission tomography. This information will therefore be helpful to those dealing with the diagnosis and therapy of cancer using radionuclides, including medical oncologists, radiation oncologists, oncologic surgeons, nuclear medicine physicians and radiologists. Attention is devoted to potential areas of clinical research in nuclear oncology. Therapeutic use of radionuclides is emphasized.