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Hepatitis C In Developing Countries

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Hepatitis C in Developing Countries

Hepatitis C in Developing Countries Book
Author : Sanaa M. Kamal
Publisher : Academic Press
Release : 2017-11-23
ISBN : 0128032340
Language : En, Es, Fr & De

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Book Description :

Hepatitis C in Developing Countries: Current and Future Challenges explores the current state of HCV in several countries, including Africa, Asia and South America. It maintains a dedicated focus on the epidemiology, clinical patterns, virologic diversity, coinfections, natural history and progression, complications, and response to standard of care (SOC) pegylated interferon and ribavirin therapy of HCV with recommendations specific to middle and low income countries. Readers will find detailed information on the burden of HCV infection from a global health and economic perspective, along with data from multicenter trials on DAAs that have enrolled patients infected with HCV non-genotype 1. Features coverage on the prevention of, or inhibition of, liver fibrosis, cirrhosis, and hepatocellular carcinoma Presents data from trials on patients with diverse ethnic backgrounds and those infected with genotypes 3, 4, 5, 6 Addresses the epidemiology, modes of transmission, socio-political aspects, genotypes, and co-infections of Hepatitis C

HCV and Related Liver Diseases

HCV and Related Liver Diseases Book
Author : Kiwamu Okita
Publisher : Springer Science & Business Media
Release : 2012-12-06
ISBN : 4431684883
Language : En, Es, Fr & De

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Book Description :

More than 2 million people in Japan have chronic hepatitis C and many of them will lose their lives to liver cirrhosis or complications of hepatocellular carcinoma. Hepatitis C virus-related diseases are a serious concern both in developing countries and in Japan and the United States, where the number of patients is also in the millions. Therapeutic modalities recently developed in Japan, including interferon therapy and nutritional supportive therapy, are gaining worldwide acceptance. At this critical juncture, HCV and Related Liver Diseases presents new information on etiology, pathology, diagnosis, and therapy. Viral hepatitis was the theme of the Yamaguchi Symposium on Liver Disease, meeting in December 1998 and attended by leading hepatologists and virologists. Collected in this volume are the papers from the symposium, providing a valuable resource for hepatologists, gastroenterologists, and others working to understand and treat viral hepatitis.

Hepatitis C Virus NS3 NS5A and NS5B Proteins as Drug Targets

Hepatitis C Virus NS3  NS5A and NS5B Proteins as Drug Targets Book
Author : Mazhar Iqbal,Moazur Rahman,Anwar Muhammad Ikram,Muhammad Ikram Anwar
Publisher : LAP Lambert Academic Publishing
Release : 2014-11-12
ISBN : 9783659634703
Language : En, Es, Fr & De

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Book Description :

Hepatitis C virus (HCV) infects 3% of world population with significant mortalities in developing countries. If HCV disease goes untreated, it can lead to cirrhosis, hepatocellular carcinoma and ultimately death of the patient. Currently in Pakistan, about 5 to 10% of population is infected with HCV. This book provides useful informations about diagnostic, prevalence and drug discovery initiative against HCV genotype-3a (HCV-3a), the most prevalent genotype in developing world, particularly in South Asia including Pakistan. Drug discovery imitative is pursued by exploring the expression, purification and characterization of HCV-3a proteins such as NS3, NS5A and N5B, which are the targets of antiviral drugs. The newly developed direct acting antiviral drugs are less effective against HCV-3a as compared to genotype-1, therefore, studies describe in this book will help the relevant scientific professionals in designing better strategies to develop potent drugs against HCV-3a. From both, pharmaceutical market or human life saving point of views, there is a huge potential to develop cost effective and safer drugs to treat life-threatening disease caused by HCV.

Recommendations and guidance on hepatitis C virus self testing

Recommendations and guidance on hepatitis C virus self testing Book
Author : World Health Organization
Publisher : World Health Organization
Release : 2021-07-15
ISBN : 924003112X
Language : En, Es, Fr & De

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Book Description :

WHO has set a global goal to eliminate HCV as a public health problem by 2030. WHO estimates that 58 million people had chronic hepatitis C virus (HCV) infection globally in 2019, and less than a quarter of them were diagnosed. New and innovative approaches are needed to accelerate progress toward the HCV elimination targets. Self-testing is one such approach. These guidelines provide a new recommendation and guidance on HCV self-testing to complement existing HCV testing services in countries. These guidelines also highlight operational considerations to support strategic implementation and scale up of HCV self-testing.

Modulation of Cell Proliferation Pathways by the Hepatitis B Virus X Protein A Potential Contributor to the Development of Hepatocellular Carcinoma

Modulation of Cell Proliferation Pathways by the Hepatitis B Virus X Protein  A Potential Contributor to the Development of Hepatocellular Carcinoma Book
Author : Jessica C. Casciano,Bei Yang,Michael J. Bouchard,Sumedha Bagga
Publisher : Unknown
Release : 2012
ISBN : 9789535100232
Language : En, Es, Fr & De

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Book Description :

Download Modulation of Cell Proliferation Pathways by the Hepatitis B Virus X Protein A Potential Contributor to the Development of Hepatocellular Carcinoma book written by Jessica C. Casciano,Bei Yang,Michael J. Bouchard,Sumedha Bagga, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Hepatocellular Carcinoma

Hepatocellular Carcinoma Book
Author : Joseph W.Y. Lau
Publisher : BoD – Books on Demand
Release : 2012-02-10
ISBN : 9535100238
Language : En, Es, Fr & De

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Book Description :

Hepatocellular Carcinoma represents a leading cause of cancer death and a major health problem in developing countries where hepatitis B infection is prevalent. It has also become increasingly important with the increase in hepatitis C infection in developed countries. Knowledge of hepatocellular carcinoma has progressed rapidly. This book is a compendium of papers written by experts to present the most up-to-date knowledge on hepatocellular carcinoma. This book deals mainly with the basic research aspect of hepatocellular carcinoma. The book is divided into three sections: (I) Biomarkers / Therapeutic Target; (II) Carcinogenesis / Invasion / Metastasis; and (III) Detection / Prevention / Prevalence. There are 18 chapters in this book. This book is an important contribution to the basic research of hepatocellular carcinoma. The intended readers of this book are scientists and clinicians who are interested in research on hepatocellular carcinoma. Epidemiologists, pathologists, hospital administrators and drug manufacturers will also find this book useful.

Reviews on the Epidemiology Quality of Life and Management of Chronic Hepatitis B CHB

Reviews on the Epidemiology  Quality of Life  and Management of Chronic Hepatitis B  CHB   Book
Author : Elegance T.P. Lam,Cindy L.K. Lam
Publisher : Unknown
Release : 2012
ISBN : 9789535100232
Language : En, Es, Fr & De

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Book Description :

Download Reviews on the Epidemiology Quality of Life and Management of Chronic Hepatitis B CHB book written by Elegance T.P. Lam,Cindy L.K. Lam, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Hepatocellular Carcinoma

Hepatocellular Carcinoma Book
Author : Joseph W.Y. Lau
Publisher : IntechOpen
Release : 2012-02-10
ISBN : 9789535100232
Language : En, Es, Fr & De

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Book Description :

Hepatocellular Carcinoma represents a leading cause of cancer death and a major health problem in developing countries where hepatitis B infection is prevalent. It has also become increasingly important with the increase in hepatitis C infection in developed countries. Knowledge of hepatocellular carcinoma has progressed rapidly. This book is a compendium of papers written by experts to present the most up-to-date knowledge on hepatocellular carcinoma. This book deals mainly with the basic research aspect of hepatocellular carcinoma. The book is divided into three sections: (I) Biomarkers / Therapeutic Target; (II) Carcinogenesis / Invasion / Metastasis; and (III) Detection / Prevention / Prevalence. There are 18 chapters in this book. This book is an important contribution to the basic research of hepatocellular carcinoma. The intended readers of this book are scientists and clinicians who are interested in research on hepatocellular carcinoma. Epidemiologists, pathologists, hospital administrators and drug manufacturers will also find this book useful.

A National Strategy for the Elimination of Hepatitis B and C

A National Strategy for the Elimination of Hepatitis B and C Book
Author : National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Population Health and Public Health Practice,Committee on a National Strategy for the Elimination of Hepatitis B and C
Publisher : National Academies Press
Release : 2017-06-30
ISBN : 0309457327
Language : En, Es, Fr & De

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Book Description :

Hepatitis B and C cause most cases of hepatitis in the United States and the world. The two diseases account for about a million deaths a year and 78 percent of world's hepatocellular carcinoma and more than half of all fatal cirrhosis. In 2013 viral hepatitis, of which hepatitis B virus (HBV) and hepatitis C virus (HCV) are the most common types, surpassed HIV and AIDS to become the seventh leading cause of death worldwide. The world now has the tools to prevent hepatitis B and cure hepatitis C. Perfect vaccination could eradicate HBV, but it would take two generations at least. In the meantime, there is no cure for the millions of people already infected. Conversely, there is no vaccine for HCV, but new direct-acting antivirals can cure 95 percent of chronic infections, though these drugs are unlikely to reach all chronically-infected people anytime soon. This report, the second of two, builds off the conclusions of the first report and outlines a strategy for hepatitis reduction over time and specific actions to achieve them.

Proteoglycans in Chronic Liver Disease and Hepatocellular Carcinoma An Update

Proteoglycans in Chronic Liver Disease and Hepatocellular Carcinoma  An Update Book
Author : Péter Tátrai,Ilona Kovalszky
Publisher : Unknown
Release : 2012
ISBN : 9789535100232
Language : En, Es, Fr & De

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Book Description :

Download Proteoglycans in Chronic Liver Disease and Hepatocellular Carcinoma An Update book written by Péter Tátrai,Ilona Kovalszky, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Guidelines for the Screening Care and Treatment of Persons with Hepatitis C Infection

Guidelines for the Screening Care and Treatment of Persons with Hepatitis C Infection Book
Author : World Health Organization
Publisher : Unknown
Release : 2015-03-31
ISBN : 9789241548755
Language : En, Es, Fr & De

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Book Description :

These are the first guidelines dealing with hepatitis C treatment produced by the World Health Organization (WHO) and complement existing guidance on the prevention of transmission of bloodborne viruses, including HCV. They are intended for policy-makers, government officials, and others working in low- and middleincome countries who are developing programmes for the screening, care and treatment of persons with HCV infection. These guidelines serve as a framework that can allow the expansion of clinical services to patients with HCV infection, as they provide key recommendations in these areas and discuss considerations for implementation. The guidelines are also intended for health-care providers who care for persons with HCV infection in low- and middle-countries and provide them guidance in the management of patients infected with HCV.

Hepatitis B C Infection Among Voluntary Blood Donors

Hepatitis B   C Infection Among Voluntary Blood Donors Book
Author : Omosigho Omoruyi Pius
Publisher : LAP Lambert Academic Publishing
Release : 2013-01
ISBN : 9783659324161
Language : En, Es, Fr & De

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Book Description :

In many developing countries, the relative contribution of various routes of blood borne hepatitis infection have not been defined in population based studies due to lack of universal and appropriate blood screening policy in these countries the risk of post-transfusion hepatitis infection is still very high. This study was carried out to determine the seroprevalence of blood borne hepatitis B & C among blood donors by Rapid Chromatogenic Enzyme Immunoassay (EIA). One hundred and ninety eight (198) samples were collected from blood donors' population in Bida within the age range of 20 and 52 years. Twenty(10.1%) were seropositive for Hepatitis B surface antigen and Four(2.0%) were seropositive for Hepatitis C virus antibodies. Of these positive cases for Hepatitis B surface antigen, the highest frequency of 11(55%) was found among age group 30-39 years interval. There was no significant statistical difference (p>0.05) between seroprevalence of Hepatitis B surface antigen and age group among blood donors population in Bida. The findings of this study evaluate the evidence on risks and benefits of screening for all blood borne hepatitis as a policy in safe blood transfusion practice.

Hepatitis ECAB

Hepatitis   ECAB Book
Author : Abhijit Chowdhury
Publisher : Elsevier Health Sciences
Release : 2009-07-15
ISBN : 8131231860
Language : En, Es, Fr & De

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Book Description :

Hepatitis means inflammation of the liver, which can be classified as acute or chronic depending upon the duration of the condition. Various etiological agents have been correlated with the occurrence of various forms of the disease. The developed countries have a majority of drug-induced and toxic liver injury, while the developing countries like India present with a majority of feco-oral and blood borne transmissions of the disease. Viral hepatitis virtually constitutes a separate etiological group. It causes a set of typical clinical, biochemical, and histological changes with or without icterus resulting from hepatic cell damage. It may be acute or chronic. The acute form causes considerable morbidity and mortality, and the chronic sequelae may prove to be fatal by resulting in liver cirrhosis and hepatocellular carcinoma (HCC). Hepatitis A and E are transmitted feco-orally, while B and C are transmitted only through blood/secretions. Hepatitis D occurs only in association with hepatitis B. Morphological pattern of liver injury in acute hepatitis varies with etiology and severity of insult. The typical lesion in all forms of acute viral hepatitis is panlobular infiltration with mononuclear cells, predominantly lymphocytes, hepatic cell necrosis, and variable degree of cholestasis, Kupffer cell hyperplasia. In fulminant hepatic failure, massive hepatic necrosis results in a soft shrunken liver. All forms of acute viral hepatitis run similar clinical course, which include incubation period after infection during which they are asymptomatic, followed by prodromal, icteric, and convalescent phases. Extrahepatic manifestations of viral hepatitis include renal, neurological, and hematological disorders. Most patients with acute viral hepatitis recover with supportive management. Hospitalization is required only in severe cases as evidenced by prolonged PT, altered sensorium, deep jaundice with ascites. Identification of etiology of acute hepatitis is of prime importance for the treatment of hepatitis. Definitive therapy is needed in drug-induced hepatitis. Most mild forms of viral hepatitis resolve with supportive treatment. Progressive liver failure mandates urgent liver transplantation. Prognostic models (Kings’ College criteria, Clichy’s criteria) have been developed for early identification of patients who would require liver transplant.

Tissue Factor Pathway Inhibitor 2 Inhibits the Growth and Invasion of Hepatocellular Carcinoma Cells and is Inactivated in Human Hepatocellular Carcinoma

Tissue Factor Pathway Inhibitor 2 Inhibits the Growth and Invasion of Hepatocellular Carcinoma Cells and is Inactivated in Human Hepatocellular Carcinoma Book
Author : Yong Xu,Jinjing Zhou,Wuxian Li,Xiao Bi,Xiaolin Qin,Xiaoqing Fan,Yi Zhang,Zhiguang Tu
Publisher : Unknown
Release : 2012
ISBN : 9789535100232
Language : En, Es, Fr & De

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Book Description :

Download Tissue Factor Pathway Inhibitor 2 Inhibits the Growth and Invasion of Hepatocellular Carcinoma Cells and is Inactivated in Human Hepatocellular Carcinoma book written by Yong Xu,Jinjing Zhou,Wuxian Li,Xiao Bi,Xiaolin Qin,Xiaoqing Fan,Yi Zhang,Zhiguang Tu, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Contemporary Obstetrics and Gynecology for Developing Countries

Contemporary Obstetrics and Gynecology for Developing Countries Book
Author : Friday E. Okonofua,Joseph A. Balogun,Kunle Odunsi,Victor N. Chilaka
Publisher : Springer Nature
Release : 2021
ISBN : 3030753859
Language : En, Es, Fr & De

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Book Description :

This book is a comprehensive and easy-to-read guide to obstetrics and gynecology in developing countries. Although significant progress has been made towards the reduction of maternal mortality and morbidity globally, they are still unacceptably high in developing countries. This can be directly or indirectly tied to poor quality maternal health care and lack of access to cost-effective, comprehensive healthcare. Health practitioners in developing countries also contend with trying to keep abreast of recent developments in obstetrics and gynecology while dealing with lack of time, resources, and access to relevant information. This textbook was thus created by experts in obstetrics and gynecology with extensive experience in African clinical settings and consultants in developed countries to teach proper and accurate diagnosis, treatment and management of gynecologic and obstetric health issues within the context of developing countries. This second edition has been fully updated throughout with an added 25+ chapters that cover topics such as reproductive health, gynecological cancers and research methods. The book is divided into six sections: Women's Reproductive Health; Obstetrics; Medical and Surgical Disorders in Pregnancy; General Gynecology; Gynecological Malignancies; Health Systems Organization, Research Methodology and Biostatistics. These section topics have been carefully covered by expert authors with the use of valid scientific data, policy instruments, and adapted to the cultural and social context of developing countries, with particular in depth coverage of conditions that have greater prevalence and incidence in developing countries. Each chapter also focuses on filling gaps in knowledge with a distinct pedagogical approach, starting with a set of learning objectives and ending with key takeaways for the chapter. This is an ideal guide for residents, medical students, practitioners of obstetrics and gynecology, midwives, general practitioners, and pediatricians, particularly those working in developing companies.

Vital Research in Hepatocellular Carcinoma

Vital Research in Hepatocellular Carcinoma Book
Author : Jay Amsel
Publisher : Unknown
Release : 2015-01-10
ISBN : 9781632424266
Language : En, Es, Fr & De

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Book Description :

Research-focused information regarding hepatocellular carcinoma has been illustrated in this all-inclusive book. Hepatocellular Carcinoma is a leading cause of cancer death and an important health problem in developing countries where hepatitis B infection is widespread. It has also gained significance with increase in hepatitis C infection in developed countries. Information on hepatocellular carcinoma has developed rapidly. This book is a well detailed publication produced as a result of the efforts of professionals and discusses the most updated information on hepatocellular carcinoma. It essentially deals with the basic research characteristics of hepatocellular carcinoma. Several topics like Biomarkers / Therapeutic Target, Detection / Prevention / Prevalence and Carcinogenesis / Invasion / Metastasis have been elucidated in this book. This book makes vital contributions to the fundamental research of hepatocellular carcinoma. The targeted readers of this book are experts and professionals involved in research on hepatocellular carcinoma. Pathologists, epidemiologists, hospital managers and drug producers will also find this book relevant as a handy source of reference.

Hepatitis C Virus The Next Epidemic An issue of Gastroenterology Clinics of North America

Hepatitis C Virus  The Next Epidemic  An issue of Gastroenterology Clinics of North America  Book
Author : K. Rajender Reddy
Publisher : Elsevier Health Sciences
Release : 2016-01-07
ISBN : 0323402496
Language : En, Es, Fr & De

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Book Description :

There are over 180 million people with chronic HCV infection worldwide with between 2.7 and 3.9 million in the United States. Hepatitis C most significantly affects Asia and Africa, with rates up to 15% in countries such as Egypt and up to 30% in certain regions such as Punjab, Pakistan. Hepatitis C places a significant burden on the public health infrastructure, as it remains the leading cause of chronic liver disease, accounting for 50-75% of primary liver cancers and is responsible for 30% of all liver transplantations. It is estimated to have cost the United States $5.5 billion in 1997, comparable to the national cost of asthma, $5.8 billion in 1994.This number is only expected to grow as the current HCV population ages, increasing overall rates of compensated cirrhosis/end-stage liver disease. The evolution of directly acting anti-virals has ushered in a new era for chronic hepatitis C. Ongoing drug development strategy has involved targeting several replication steps of the virus and the hope is to see all oral therapies by late 2014 or early 2015. Thus we are at an exciting cross roads with regard to new information and challenges with HCV: rising disease burden with associated high costs, the challenges globally and in multiple patient populations, and the impending availability of effective and well tolerated treatments. Therefore there is a need to commission an exclusive issue of GCNA for HCV.

Hepatocellular Carcinoma Methods of Circulating Tumor Cells CTC Measurements

Hepatocellular Carcinoma  Methods of Circulating Tumor Cells  CTC  Measurements Book
Author : Natalia Olaya,Franck Chiappini
Publisher : Unknown
Release : 2012
ISBN : 9789535100232
Language : En, Es, Fr & De

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Book Description :

Download Hepatocellular Carcinoma Methods of Circulating Tumor Cells CTC Measurements book written by Natalia Olaya,Franck Chiappini, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.