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Hands On Approach For The Conduct Of Nonclinical Studies

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Targeted Therapy in Translational Cancer Research

Targeted Therapy in Translational Cancer Research Book
Author : Apostolia-Maria Tsimberidou,Razelle Kurzrock,Kenneth C. Anderson
Publisher : John Wiley & Sons
Release : 2015-10-08
ISBN : 1118468686
Language : En, Es, Fr & De

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Book Description :

Targeted Therapy in Translational Cancer Research for the Translational Oncology series provides a comprehensive overview of recent developments in our understanding of tumor biology, elucidates the roles of targets and pathways involved in carcinogenesis, and describes current state-of-the-art anticancer therapy, as well as the most promising areas of translational research and targeted therapy. Introduces cutting-edge ‘bench to bedside and back’ breakthroughs which have transformed the diagnosis, prognosis, and treatment of cancer Covers basic principles of targeted therapy, including immunotherapy and the roles of cancer stem cells, the microenvironment, angiogenesis, epigenetics, microRNAs, and functional imaging in precision medicine Summarises major advances in therapeutic management of hematologic malignancies and solid tumors using conventional therapy, targeted therapy, immunotherapy, or novel treatment modalities

Global Approach in Safety Testing

Global Approach in Safety Testing Book
Author : Jan Willem van der Laan,Joseph J DeGeorge
Publisher : Springer Science & Business Media
Release : 2013-02-11
ISBN : 1461459508
Language : En, Es, Fr & De

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Book Description :

This volume will consider one of ICH’s major categories, Safety i.e. topics relating to in vitro and in vivo pre-clinical studies (Carcinogenicity Testing, Genotoxicity Testing, etc.). Since the start of the ICH process, many guidelines have been written, but even after ICH6 no explanations have been given during a formal Congress about the background of the ICH Guidance documents. Even more important than what has been written, might have been those thoughts of the experts that are not included in the Guidance documents. Why has the guideline been written as it is written, and why have some aspects been deleted. These and other related questions are the contents of this book, written by experts who were involved in the ICH process. Furthermore, the chapters will contain discussions on the “lessons learnt” and “future developments”.

Nonhuman Primates in Biomedical Research

Nonhuman Primates in Biomedical Research Book
Author : Christian R. Abee,Keith Mansfield,Suzette D. Tardif,Timothy Morris
Publisher : Academic Press
Release : 2012-05-09
ISBN : 0123978378
Language : En, Es, Fr & De

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Book Description :

The 2e of the gold standard text in the field, Nonhuman Primates in Biomedical Research provides a comprehensive, up-to-date review of the use of nonhuman primates in biomedical research. The Biology and Management volume provides basic information on the natural biology of nonhuman primates and the current state of knowledge regarding captive management. Each chapter contains an extensive list of bibliographic references, photographs, and graphic illustrations to provide the reader with a thorough review of the subject. Now in four color throughout, making the book more visually stimulating to enhance learning and ease of use Fully revised and updated, providing researchers with the most comprehensive review of the use of nonhuman primates in biomedical research Addresses commonly used nonhuman primate biomedical models, providing researchers with species-specific information

Current Index to Journals in Education

Current Index to Journals in Education Book
Author : Anonim
Publisher : Unknown
Release : 1996-10
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Current Index to Journals in Education book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Psychological Abstracts

Psychological Abstracts Book
Author : American psychological association
Publisher : Unknown
Release : 2003
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Psychological Abstracts book written by American psychological association, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

New Scientist

New Scientist Book
Author : Anonim
Publisher : Unknown
Release : 2007
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download New Scientist book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Handbook of Organizational Design Adapting organizations to their environments

Handbook of Organizational Design  Adapting organizations to their environments Book
Author : Professor of Business Administration Paul C Nystrom,Paul C. Nystrom,William H. Starbuck
Publisher : Oxford ; New York : Oxford University Press
Release : 1981
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

The two volumes summarize and reinterpret research and suggest applications to the design of organizations. Volume I analyses the effects of environments on organizations, and discusses the adaptive capabilities of organizations such as planning, forecasting, and innovation.

Pharmacokinetics

Pharmacokinetics Book
Author : Peter G. Welling
Publisher : Amer Chemical Society
Release : 1997
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Pharmacokinetics is the study of the absorption, distribution, metabolism, and excretion of drugs in humans. This book, written by an internationally known researcher, teaches the basic principles, including drug transport, parenteral and enteral routes of drug administration, and factors affecting drug absorption, distribution, and metabolism. Extensively revised, this edition presents the mathematics of pharmacokinetics with various single- and multi-compartment models including detailed descriptions of metabolite and nonlinear pharmacokinetics. It also describes renal and hepatic drug clearance, and the influence of kidney and liver impairment on these functions. Taking a tutorial approach throughout, the author provides both a clear introduction to pharmacokinetics and a critical look at how this science affects drug discovery and development.

Population Studies

Population Studies Book
Author : Anonim
Publisher : Unknown
Release : 1948
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Population Studies book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Cancer Research

Cancer Research Book
Author : Anonim
Publisher : Unknown
Release : 2001-11
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Cancer Research book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Psychology

Psychology Book
Author : Addison-Wesley Longman, Incorporated
Publisher : Unknown
Release : 1997
ISBN : 9780673998965
Language : En, Es, Fr & De

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Book Description :

Download Psychology book written by Addison-Wesley Longman, Incorporated, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Biotechnology Recombinant Proteins Monoclonal Antibodies and Therapeutic Genes

Biotechnology  Recombinant Proteins  Monoclonal Antibodies  and Therapeutic Genes Book
Author : A. Mountain,U. M. Ney,Dietmar Schomburg
Publisher : Wiley-Blackwell
Release : 1999-03-19
ISBN : 9783527283156
Language : En, Es, Fr & De

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Book Description :

In the field of medicinal biotechnology three major developments have caused a revolution in research that has a lot of innovative effects on clinical medicine and future applications on humans. With the availability of tailored recombinant proteins and the opportunity to produce high amounts of monoclonal antibodies new diagnostic applications have emerged and many therapeutic perspectives, e.g. in the treatment of multiple sclerosis and of cancer, are being discussed today. The aim of somatic gene therapy is to re-establish normal cell function by supplying the cells with the respective intact gene. This is a very difficult task and different diseases, e.g. AIDS and several metabolic disorders, are under investigation now. So far first promising approaches exist in cancer therapy. Moreover the book informs about regulatory and economic aspects of these new methods and their applications.

Studies to Enhance the Evaluation of Family Planning Programmes

Studies to Enhance the Evaluation of Family Planning Programmes Book
Author : United Nations. Department of International Economic and Social Affairs. Population Division
Publisher : Unknown
Release : 1985
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Studies to Enhance the Evaluation of Family Planning Programmes book written by United Nations. Department of International Economic and Social Affairs. Population Division, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

AMSTAT News

AMSTAT News Book
Author : Anonim
Publisher : Unknown
Release : 2005
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download AMSTAT News book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Schizophrenia Bulletin

Schizophrenia Bulletin Book
Author : Anonim
Publisher : Unknown
Release : 1994
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

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Developmental and Reproductive Toxicology

Developmental and Reproductive Toxicology Book
Author : Ronald D Hood
Publisher : CRC Press
Release : 2011-12-14
ISBN : 9781841847771
Language : En, Es, Fr & De

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Book Description :

The purpose of this third edition of Developmental and Reproductive Toxicology is to provide a practical guide to developmental and reproductive toxicology in a regulatory environment. In addition to a comprehensive update of current chapters, the third edition been revised to reflect recent changes in the field. It contains new chapters that reflect emerging topics of interest, including testing of biologics (including vaccines), nonhuman primates as nonclinical models, developmental immunotoxicity testing, in vitro assays (such as use of zebrafish and stem cells, as well as high throughput screening), in silico systems modelling, evaluating mechanisms of reproductive toxicity, in-depth coverage of neurobehavioral testing, and testing under the EU’s REACH regulations, as well as updated chapters on nonclinical juvenile toxicity testing, endocrine disruptor screening, and on functional and computational genomics. The study of hazard and risk associated with exposure to toxicants during prenatal development has been expanded in recent years to include effects on development until the time of puberty. Concern over the adverse effects of chemical or physical agents on the reproductive processes of both sexes has increased, and progress has been made in identifying the causes and mechanisms eliciting congenital defects and determining the genetic, epigenetic, and environmental factors involved. This book provides up-to-date guidance on the use and interpretation of the newest research techniques in developmental and reproductive toxicology, as well as the more traditional approaches. Developmental and Reproductive Toxicology, Third Edition: Contains valuable insights gained from hands-on experience, together with a critical evaluation of current testing strategies. Includes guidance for the design, conduct, and interpretation of tests in all areas of developmental and reproductive toxicity. Contains reprinted guidelines from major regulatory agencies, as well as terminology for description of developmental abnormalities in laboratory animals, for easy reference. Provides guidance for planning and conducting preclinical toxicity studies and follow-up studies, and interpreting their results in a regulatory environment. This book continues to be the ideal practical reference for developmental and reproductive toxicologists who perform research in industry, government, and academia and for anyone who intends to enter these research areas.

Veterinary and Human Toxicology

Veterinary and Human Toxicology Book
Author : Anonim
Publisher : Unknown
Release : 1992
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Veterinary and Human Toxicology book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Directory of Research Grants 2002

Directory of Research Grants 2002 Book
Author : Grants Program,Oryx Publishing
Publisher : Greenwood
Release : 2002
ISBN : 9781573564885
Language : En, Es, Fr & De

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Book Description :

More than 5,100 current programs from 1,880 sponsors, including U.S. and foreign foundations, corporations, government agencies, and other organizations.

Comprehensive toxicology

Comprehensive toxicology Book
Author : I. Glenn Sipes,Charlene A. McQueen,A. Jay Gandolfi
Publisher : Unknown
Release : 1997
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Comprehensive toxicology book written by I. Glenn Sipes,Charlene A. McQueen,A. Jay Gandolfi, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

International Co ordination of Drug Trials Rheumatological Research and the Fight Against Rheumatic Diseases in Switzerland

International Co ordination of Drug Trials  Rheumatological Research  and the Fight Against Rheumatic Diseases in Switzerland Book
Author : Anonim
Publisher : Unknown
Release : 1978
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download International Co ordination of Drug Trials Rheumatological Research and the Fight Against Rheumatic Diseases in Switzerland book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.