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Handbook Of Proteolytic Enzymes

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Handbook of Proteolytic Enzymes

Handbook of Proteolytic Enzymes Book
Author : Alan J. Barrett,Neil D. Rawlings,J. Fred Woessner
Publisher : Academic Press
Release : 2012-10-30
ISBN : 0123822203
Language : En, Es, Fr & De

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Book Description :

The third edition of the Handbook of Proteolytic Enzymes is a comprehensive reference work for the enzymes that cleave proteins and peptides, written by acknowledged experts in the field and containing over 850 chapters. Each chapter is organized into sections describing the name and history, activity and specificity, structural chemistry, preparation, biological aspects, and distinguishing features for a specific peptidase. There are also introductory chapters on peptidase classification and mechanisms and a comprehensive index. For the first time, the Handbook is also available online via Elsevier's ScienceDirect platform as well as a three-volume book. The online version has enhanced options, including online multimedia, cross-referencing capabilities, integrated online delivery and closer integration with the online MEROPS database of peptidases and their inhibitors. This reference work is a must-have for biochemists, biotechnologists, molecular biologists and students in these disciplines, and will be of great interest to pharmaceutical and biotechnology companies. Contains over 830 chapters Covers new research in therapeutics and drug trials Supplies content written by experts in the field

Handbook of Proteolytic Enzymes Volume 1

Handbook of Proteolytic Enzymes  Volume 1 Book
Author : Alan J. Barrett,J. Fred Woessner,Neil D. Rawlings
Publisher : Elsevier
Release : 2012-12-02
ISBN : 0080984150
Language : En, Es, Fr & De

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Book Description :

Handbook of Proteolytic Enzymes, Second Edition, Volume 1: Aspartic and Metallo Peptidases is a compilation of numerous progressive research studies on proteolytic enzymes. This edition is organized into two main sections encompassing 328 chapters. This handbook is organized around a system for the classification of peptidases, which is a hierarchical one built on the concepts of catalytic type, clan, family and peptidase. The concept of catalytic type of a peptidase depends upon the chemical nature of the groups responsible for catalysis. The recognized catalytic types are aspartic, cysteine, metallo, serine, threonine, and the unclassified enzymes, while clans and families are groups of homologous peptidases. Homology at the level of a family of peptidases is shown by statistically significant relationship in amino acid sequence to a representative member called the type example, or to another member of the family that has already been shown to be related to the type example. Each chapter discusses the history, activity, specificity, structural chemistry, preparation, and biological aspects of the enzyme. This book will prove useful to enzyme chemists and researchers.

Handbook of Proteolytic Enzymes

Handbook of Proteolytic Enzymes Book
Author : J. F. Woessner,Neil D. Rawlings,Alan J. Barrett
Publisher : Academic Press
Release : 2004-06-30
ISBN : 9780120796106
Language : En, Es, Fr & De

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Book Description :

Extensively revised and updated, the new edition of the highly regarded Handbook of Proteolytic Enzymes is an essential reference for biochemists, biotechnologists and molecular biologists. Edited by world-renowned experts in the field, this comprehensive work provides detailed information on all known proteolytic enzymes to date. This two-volume set unveils new developments on proteolytic enzymes which are being investigatedin pharmaceutical research for such diseases as HIV, Hepatitis C, and the common cold. Volume I covers aspartic and metallo petidases while Volume II examines peptidases of cysteine, serine, threonine and unknown catalytic type. A CD-ROM accompanies the book containing fully searchable text, specialised scissile bond searches, 3-D color structures and much more. * The only comprehensive book on proteolytic enzymes * Includes 671 chapters, each written by experts in their field, on proteolytic enzymes from all groups of living organisms and the viruses, including those that are currently major targets of pharmaceutical research * Accompanying CD-ROM provides fully searchable text, 2D structures of peptidases in color and links directly to PubMed and MEROPS databases *Each chapter describes in detail the enzyme name, its history, activity and specificity, structural chemistry, preparation, biological aspects and distinguishing features *Over 1000 peptidases included

Handbook of Proteolytic Enzymes

Handbook of Proteolytic Enzymes Book
Author : Neil D. Rawlings
Publisher : Academic Press
Release : 2022-12-15
ISBN : 9780128225738
Language : En, Es, Fr & De

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Book Description :

The Handbook of Proteolytic Enzymes has stood as most comprehensive work in the field of applied enzymology and biocatalysis since the first edition published in 1998. Extensively revised and updated, the new, fourth edition is an essential reference for biochemists, biotechnologists, and molecular biologists across academia and industry. Edited by world-renowned experts in the field and with five volumes available for individual sale, this work provides detailed information on all known proteolytic enzymes researched to-date, with expanded coverage of metallopeptidases, cysteine peptidases, serine and threonine peptidases, aspartic and glutamic peptidases, and inhibitors of proteolytic enzymes. This volume, Serine and Threonine Peptidases, includes over 400 chapters on known serine and threonine peptidases, including their name, history, activity and specificity, structural chemistry, preparation, biological aspects, and distinguishing features, with 2D and 3D structures of peptidases in color, extensive references, and links to PubMed and MEROPS databases. The only comprehensive book on serine and threonine peptidases, with over 400 peptides included Each chapter written by experts in their field, on proteolytic enzymes from all groups of living organisms and viruses, including those that are currently major targets of pharmaceutical research Fully searchable text, 2D and 3D structures of peptidases in color, and links directly to PubMed and MEROPS databases Details the latest proteotases used in therapeutic research, and discusses recent drug trials

Handbook of Proteolytic Enzymes

Handbook of Proteolytic Enzymes Book
Author : Neil D. Rawlings,David S. Auld
Publisher : Academic Press
Release : 2021-06-15
ISBN : 9780128235874
Language : En, Es, Fr & De

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Book Description :

The Handbook of Proteolytic Enzymes: Metallopeptidases has stood as most comprehensive work in the field of applied enzymology and biocatalysis since the first edition published in 1998. Extensively revised and updated, the new, fourth edition?is an essential reference for biochemists, biotechnologists, and molecular biologists across academia and industry. Edited by world-renowned experts in the field and with five volumes available for individual sale, this work provides detailed information on all known proteolytic enzymes researched to-date, with expanded coverage of metallopeptidases, cysteine peptidases, serine and threonine peptidases, aspartic and glutamic peptidases, and inhibitors of proteolytic enzymes. This volume,?Metallopeptidases, includes over 300 chapters on known metallopeptidases, including their name, history, activity and specificity, structural chemistry, preparation, biological aspects, and distinguishing features, with 2D and 3D structures of peptidases in color, extensive references, and links to PubMed and MEROPS databases. The only comprehensive book on Metallopeptidases with over 300 peptides included Each chapter written by experts in their field, on proteolytic enzymes from all groups of living organisms and viruses, including those that are currently major targets of pharmaceutical research Fully searchable text, 2D and 3D structures of peptidases in color, and links directly to PubMed and MEROPS databases Details the latest proteotases used in therapeutic research, and discusses recent drug trials

Industrial Enzymes

Industrial Enzymes Book
Author : Julio Polaina,Andrew P. MacCabe
Publisher : Springer Science & Business Media
Release : 2007-05-16
ISBN : 1402053770
Language : En, Es, Fr & De

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Book Description :

Recent developments in genetic engineering and protein chemistry are bringing ever more powerful means of analysis to bear on the study of enzyme structure. This volume reviews the most important types of industrial enzymes. In a balanced manner it covers three interrelated aspects of paramount importance for enzyme performance: three-dimensional protein structure, physicochemical and catalytic properties, and the range of both classical and novel applications.

Drug Design of Zinc Enzyme Inhibitors

Drug Design of Zinc Enzyme Inhibitors Book
Author : Claudiu T. Supuran,Jean-Yves Winum
Publisher : John Wiley & Sons
Release : 2009-10-22
ISBN : 9780470508152
Language : En, Es, Fr & De

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Book Description :

Brings together functional and structural informationrelevant to the design of drugs targeting zinc enzymes The second most abundant transition element in living organisms, zinc spans all areas of metabolism, with zinc-containing proteins offering both established and potential drug targets. Drug Design of Zinc-Enzyme Inhibitors brings together functional and structural information relevant to these zinc-containing targets. With up-to-date overviews of the latest developments field, this unique and comprehensive text enables readers to understand zinc enzymes and evaluate them in a drug design context. With contributions from the leaders of today's research, Drug Design of Zinc-Enzyme Inhibitors covers such key topics as: Major drug targets like carbonic anhydrases, matrix metalloproteinases, bacterial proteases, angiotensin-converting enzyme, histone deacetylase, and APOBEC3G Roles of recently discovered zinc-containing isozymes in cancer, obesity, epilepsy, pain management, malaria, and other conditions Cross reactivity of zinc-enzyme inhibitors and activators The extensive use of X-ray crystallography and QSAR studies for understanding zinc-containing proteins Clinical applications An essential resource for the discovery and development of new drug molecules, Drug Design of Zinc-Enzyme Inhibitors gives researchers, professionals, students, and academics the foundation to understand and work with zinc enzyme inhibitors and activators.

Proteolytic Enzymes

Proteolytic Enzymes Book
Author : Alan J. Barrett
Publisher : Unknown
Release : 1995
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

In this volume of Methods in Enzymology and its companion Volume 244, the chapters on specific methods, enzymes, and inhibitors are organized within the rational framework of the new systems for classification and nomenclature. A wide variety of specificities of peptide bond hydrolysis are represented in each set of peptidases, together with an equally wide range of biological functions. Key Features * Aspartic peptidases * Metallopeptidases * New information on classification of proteolytic enzymes * Medical implications of research in this area * Biotechnological uses of these enzymes.

Advances in Parasitology

Advances in Parasitology Book
Author : Anonim
Publisher : Academic Press
Release : 2009-09-27
ISBN : 9780080950969
Language : En, Es, Fr & De

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Book Description :

First published in 1963, Advances in Parasitology contains comprehensive and up-to-date reviews in all areas of interest in contemporary parasitology. Advances in Parasitology includes medical studies on parasites of major influence, such as Plasmodium falciparum and trypanosomes. The series also contains reviews of more traditional areas, such as zoology, taxonomy, and life history, which shape current thinking and applications. Eclectic volumes are supplemented by thematic volumes on various topics, including control of human parasitic diseases and global mapping of infectious diseases. * Informs and updates on all the latest developments in the field * Contributions from leading authorities and industry experts

Handbook of Food Enzymology

Handbook of Food Enzymology Book
Author : John R. Whitaker,Alphons G. J. Voragen,Dominic W.S. Wong
Publisher : CRC Press
Release : 2002-12-05
ISBN : 0203910451
Language : En, Es, Fr & De

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Book Description :

Discussing methods of enzyme purification, characterization, isolation, and identification, this book details the chemistry, behavior, and physicochemical properties of enzymes to control, enhance, or inhibit enzymatic activity for improved taste, texture, shelf-life, nutritional value, and process tolerance of foods and food products. The book cov

Handbook of Food Analytical Chemistry Volume 1

Handbook of Food Analytical Chemistry  Volume 1 Book
Author : Ronald E. Wrolstad,Terry E. Acree,Eric A. Decker,Michael H. Penner,David S. Reid,Steven J. Schwartz,Charles F. Shoemaker,Denise M. Smith,Peter Sporns
Publisher : John Wiley & Sons
Release : 2005-09-02
ISBN : 0471709093
Language : En, Es, Fr & De

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Book Description :

Emphasizing effective, state-of-the art methodology and written byrecognized experts in the field, the Handbook of Food AnalyticalChemistry is an indispensable reference for food scientists andtechnologists to enable successful analysis. * Provides detailed reports on experimental procedures * Includes sections on background theory and troubleshooting * Emphasizes effective, state-of-the art methodology, written byrecognized experts in the field * Includes detailed instructions with annotated advisory comments,key references with annotation, time considerations and anticipatedresults

Handbook of Plant Based Fermented Food and Beverage Technology Second Edition

Handbook of Plant Based Fermented Food and Beverage Technology  Second Edition Book
Author : Y. H. Hui,E. Özgül Evranuz
Publisher : CRC Press
Release : 2012-05-17
ISBN : 1439849048
Language : En, Es, Fr & De

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Book Description :

Fermented food can be produced with inexpensive ingredients and simple techniques and makes a significant contribution to the human diet, especially in rural households and village communities worldwide. Progress in the biological and microbiological sciences involved in the manufacture of these foods has led to commercialization and heightened interest among scientists and food processors. Handbook of Plant-Based Fermented Food and Beverage Technology, Second Edition is an up-to-date reference exploring the history, microorganisms, quality assurance, and manufacture of fermented food products derived from plant sources. The book begins by describing fermented food flavors, manufacturing, and biopreservation. It then supplies a detailed exploration of a range of topics, including: Soy beverages and sauce, soymilk, and tofu Fruits and fruit products, including wine, capers, apple cider and juice, mangos, olive fruit, and noni fruits Vegetables and vegetable products, including red beet juice, eggplant, olives, pickles, sauerkraut, and jalapeño peppers Cereals and cereal products, including fermented bread, sourdough bread, rice noodles, boza, Chinese steamed buns, whiskey, and beer Specialty products such as balsamic vinegar, palm wine, cachaça, brick tea, shalgam, coconut milk and oil, coffee, and probiotic nondairy beverages Ingredients such as proteolytic bacteria, enzymes, and probiotics Fermented food products play a critical role in cultural identity, local economy, and gastronomical delight. With contributions from over 60 experts from more than 20 countries, the book is an essential reference distilling the most critical information on this food sector.

Proteases as Targets for Therapy

Proteases as Targets for Therapy Book
Author : Klaus, von der Helm,Bruce D. Korant,John C. Cheronis
Publisher : Springer Science & Business Media
Release : 2012-12-06
ISBN : 3642570925
Language : En, Es, Fr & De

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Book Description :

With contributions by numerous experts

Programmed Cell Death in Higher Plants

Programmed Cell Death in Higher Plants Book
Author : E. Lam,H. Fukuda,J. Greenberg
Publisher : Springer Science & Business Media
Release : 2000-12-31
ISBN : 0792366778
Language : En, Es, Fr & De

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Book Description :

The molecular mechanisms which determine whether the cells of a multicellular organism will live or commit suicide have become a popular field of research in biology during the last decade. Cell death research in the plant field has also been expanding rapidly in the past 5 years. This special volume of Plant Molecular Biology seeks to bring together examples of a diverse array of experimental approaches in a single volume. From the differentiation of tracheary elements in vascular plants to the more specialized cell death model of the aleurone in cereals, this volume will bring the reader up-to-date with the characterization of different plant model systems that are currently being studied. This endeavor should complement general overviews of plant cell death mechanisms that have been published elsewhere by providing more detailed information on various aspects of this field to interested graduate students and more senior biologists alike.

Aspartic Acid Proteases as Therapeutic Targets

Aspartic Acid Proteases as Therapeutic Targets Book
Author : Arun K. Ghosh
Publisher : John Wiley & Sons
Release : 2011-08-04
ISBN : 3527641629
Language : En, Es, Fr & De

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Book Description :

In this ground-breaking practical reference, the family of aspartic acid proteases is described from a drug developer's perspective. The first part provides a general introduction to the family of aspartic acid proteases, their physiological functions, molecular structure and inhibition. Parts two to five present various case studies of successful protease inhibitor drug design and development, as well as current and potential uses of such inhibitors in pharmaceutical medicine, covering the major therapeutic targets HIV-1 protease, renin, beta-secretase, gamma-secretase,plasmepsins and fungal proteases. A ready reference aimed primarily at professionals in the pharmaceutical industry, as well as for anyone studying proteases and their function.

Recent Advances in Thrombosis and Hemostasis

Recent Advances in Thrombosis and Hemostasis Book
Author : K. Tanaka,E.W. Davie
Publisher : Springer Science & Business Media
Release : 2009-01-15
ISBN : 4431788476
Language : En, Es, Fr & De

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Book Description :

Now more than ever, thrombotic and thromboembolic disorders as well as related diseases such as malignancies, arteriosclerosis, diabetes mellitus, hypertension, and obesity are the leading causes of morbidity and mortality. They have become urgent medical problems with serious economic consequences in industrialized and devel- ing countries alike. At the same time, the impact of molecular biology and genetics on our understanding of thrombosis and hemostasis is rapidly growing stronger as well as our knowledge of regeneration and development of specific tissues, organs, and embryos. Researchers are also constantly learning more about cardiovascular diseases as well as regulatory mechanisms for various intrinsic and extrinsic stimuli in viable tissues. In this volume, our intention has been to present the latest relevant information in molecular biology and genetics as well as the clinical implications of a better understanding of pathophysiology, novel diagnostic methodologies, and therapeutic applications for new methods of prevention in thrombosis/hemostasis and related disorders, including atherosclerosis. The dramatic advances in knowledge of thrombosis/hemostasis and vascular biology since the first publication of Recent Advances in Thrombosis and Fibrinolysis, edited with Japanese colleagues, in 1991, have required extensive revision in order to highlight and review recent progress in the field. The editors also gratefully welcome the seven distinguished non Japanese authors, who, with their valuable contributions on subjects beyond the coverage by Japanese authors, have made this new edition truly international.

The Handbook of Microbial Bioresources

The Handbook of Microbial Bioresources Book
Author : Vijai Kumar Gupta,Gauri Dutt Sharma,Maria G Tuohy,Rajeeva Gaur
Publisher : CABI
Release : 2016-06-27
ISBN : 178064521X
Language : En, Es, Fr & De

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Book Description :

Microbial technology plays an integral role in the biotechnology, bioengineering, biomedicine/biopharmaceuticals and agriculture sector. This book provides a detailed compendium of the methods, biotechnological routes, and processes used to investigate different aspects of microbial resources and applications. It covers the fundamental and applied aspects of microorganisms in the health, industry, agriculture and environmental sectors, reviewing subjects as varied and topical as pest control, health and industrial developments and animal feed.

Proteolytic Enzymes

Proteolytic Enzymes Book
Author : Erwin E. Sterchi,Walter Stöcker
Publisher : Springer Science & Business Media
Release : 2013-11-11
ISBN : 3642598161
Language : En, Es, Fr & De

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Book Description :

Following an overview on proteolytic enzyme assays, this text covers procedures on how to investigate and study proteases. It describes the use of specific restriction proteases as well as inhibitors of proteases to prevent unwanted proteolysis.

Handbook of Drug Administration via Enteral Feeding Tubes 3rd edition

Handbook of Drug Administration via Enteral Feeding Tubes  3rd edition Book
Author : Rebecca White,Vicky Bradnam
Publisher : Pharmaceutical Press
Release : 2015-03-11
ISBN : 0857111620
Language : En, Es, Fr & De

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Book Description :

With over 400 drug monographs, this book covers the technical, practical and legal aspects that you should consider before prescribing or administering drugs via enteral feeding tubes.

Matrix Metalloproteinase Protocols

Matrix Metalloproteinase Protocols Book
Author : Ian M. Clark
Publisher : Springer Science & Business Media
Release : 2008-02-05
ISBN : 1592590462
Language : En, Es, Fr & De

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Book Description :

Research in the matrix metalloproteinase field began with the demonstration by Gross and Lapière, in 1962, that resorbing tadpole tail expressed an enzyme that could degrade collagen gels. These humble beginnings have led us to the elucidation of around twenty distinct vertebrate MMPs, along with a variety of homologs from such diverse organisms as sea urchin, plants, nematode worm, and bacteria. This, coupled with four known specific inhibitors of MMPs, the TIMPs, gives a complex picture. Part I of Matrix Metalloproteinase Protocols provides the reader with a selective overview of the MMP arena, and a chance to come to grips with where the field has been, where it is, and where it is going. I hope that this complements all of the methodology that comes later. Part II presents the reader with a diverse set of methods for the expression and purification of MMPs and TIMPs, bringing together the long and often hard-earned experience of a number of researchers. Part III allows the reader to detect MMPs and TIMPs at both the protein and mRNA level, whereas Part IV gives the ability to assay MMP and TIMP activities in a wide variety of circumstances.