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Handbook Of Process Chromatography

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Handbook of Process Chromatography

Handbook of Process Chromatography Book
Author : Gunter Jagschies,Gail K. Sofer,Lars Hagel
Publisher : Elsevier
Release : 2007-12-08
ISBN : 9780080554518
Language : En, Es, Fr & De

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Book Description :

This book will update the original edition published in 1997. Since the publication of the first edition, the biotechnology and biologics industries have gained extensive knowledge and experience in downstream processing using chromatography and other technologies associated with recovery and purification unit operations. This book will tie that experience together for the next generation of readers. Updates include: - sources and productivity - types of products made today - experiences in clinical and licensed products - economics - current status of validation - illustrations and tables - automated column packing - automated systems New topics include: - the use of disposables - multiproduct versus dedicated production - design principles for chromatography media and filters - ultrafiltration principles and optimization - risk assessments - characterization studies - design space - platform technologies - process analytical technologies (PATs) - biogenerics - comparability assessments Key Features: - new approaches to process optimiaztion - use of patform technologies - applying risk assessment to process design

Handbook of Process Chromatography

Handbook of Process Chromatography Book
Author : Gail K. Sofer,Lars Hagel
Publisher : Academic Press
Release : 1997-07-08
ISBN :
Language : En, Es, Fr & De

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Book Description :

With examples from companies with establised processes and approved biotherapeutics, this pack considers the entire scope of process chromatography, including scale-up, regulatory issues, equipment, evaluation studies, scheduling and cost effectiveness.

Handbook of Separation Process Technology

Handbook of Separation Process Technology Book
Author : Ronald W. Rousseau
Publisher : John Wiley & Sons
Release : 1987-05-13
ISBN : 9780471895589
Language : En, Es, Fr & De

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Book Description :

Surveys the selection, design, and operation of most of the industrially important separation processes. Discusses the underlying principles on which the processes are based, and provides illustrative examples of the use of the processes in a modern context. Features thorough treatment of newer separation processes based on membranes, adsorption, chromatography, ion exchange, and chemical complexation. Includes a review of historically important separation processes such as distillation, absorption, extraction, leaching, and crystallization and considers these techniques in light of recent developments affecting them.

Handbook of Bioseparations

Handbook of Bioseparations Book
Author : Satinder Ahuja
Publisher : Elsevier
Release : 2000-06-23
ISBN : 9780080507798
Language : En, Es, Fr & De

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Book Description :

It is generally recognized that the commercial success of biotechnology products is highly dependent on the successful development and application of high-powered separation and purification methods. In this practical and authoritative handbook, the separation of proteins, nucleic acids, and oligonucleotides from biological matrices is covered from analytical to process scales. Also included in a chapter on the separation of monoclonal antibodies, which have found numerous uses as therapeutic and diagnostic agents. Analytical techniques include an interesting montage of chromatographic methods, capillary electrophoresis, isoelectric focusing, and mass spectrometry. Among separation and purification methods, liquid-liquid distribution, displacement chromatography, expanded bed adsorption, membrane chromatography, and simulated moving bed chromatography are covered at length. Regulatory and economic considerations are addressed, as are plant and process equipment and engineering process control. A chapter on future developments highlights the application of DNA chip arrays as well as evolving methodologies for a large number of drugs that are under development for treatment of cancer, AIDS, rheumatoid arthritis, and Alzheimer's disease. Handbook of Bioseparations serves as an essential reference and guidebook for separation scientists working in the pharmaceutical and biotechnology industries, academia, and government laboratories. Key Features * Covers bioseparations of proteins, nucleic acids, and monoclonal antibodies * Encompasses both analytical and process-scale methods * Elucidates the importance of engineering process control * Details selection of plant and process equipment * Addresses economic considerations * Discusses future developments

Handbook of Methods and Instrumentation in Separation Science

Handbook of Methods and Instrumentation in Separation Science Book
Author : N.A
Publisher : Academic Press
Release : 2009-11-11
ISBN : 9780123757272
Language : En, Es, Fr & De

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Book Description :

Handbook of Methods and Instrumentation in Separation Science, Volume 1 provides concise overviews and summaries of the main methods used for separation. It is based on the Encyclopedia of Separation Science. The handbook focuses on the principles of methods and instrumentation. It provides general concepts concerning the subject matter; it does not present specific procedures. This volume discusses the separation processes including affinity methods, analytical ultracentrifugation, centrifugation, chromatography, and use of decanter centrifuge and dye. Each methodology is defined and compared with other separation processes. It also provides specific techniques, principles, and theories concerning each process. Furthermore, the handbook presents the applications, benefits, and validation of the processes described in this book. This handbook is an excellent reference for biomedical researchers, environmental and production chemists, flavor and fragrance technologists, food and beverage technologists, academic and industrial librarians, and nuclear researchers. Students and novices will also find this handbook useful for practice and learning. One-stop source for information on separation methods General overviews for quick orientation Ease of use for finding results fast Expert coverage of major separation methods Coverage of techniques for all sizes of samples, pico-level to kilo-level

Handbook of Biogeneric Therapeutic Proteins

Handbook of Biogeneric Therapeutic Proteins Book
Author : Sarfaraz K. Niazi
Publisher : CRC Press
Release : 2002-08-15
ISBN : 1000611329
Language : En, Es, Fr & De

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Book Description :

More than 20 billion dollars worth of biopharmaceuticals are scheduled to go off-patent by 2006. Given the strong political impetus and the development of technological tools that can answer the questions regulatory authorities may raise, it is inevitable that the FDA and EMEA will allow biogeneric or biosimilar products. Even with all the regulato

Handbook of Downstream Processing

Handbook of Downstream Processing Book
Author : E. Goldberg
Publisher : Taylor & Francis
Release : 1997
ISBN : 9780751403640
Language : En, Es, Fr & De

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Book Description :

The last two decades have witnessed a phenomenal growth in the field of genetic or biochemical engineering, and a variety of products has been developed and marketed through the manipulation and growth of different types of microorganisms and the recovery and purification of the associated products.

CRC Handbook of Chromatography

CRC Handbook of Chromatography Book
Author : Kumar D. Mukherjee,Nikolaus Weber
Publisher : CRC Press
Release : 1993-05-06
ISBN : 9780849330391
Language : En, Es, Fr & De

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Book Description :

Handbook of Chromatography: Analysis of Lipids provides a valuable review of state-of-the-art applications of chromatographic techniques (TLC, GC, HPLC) and other analytical techniques. Much of this volume is devoted to applications of HPLC (including supercritical fluid chromatography) in the analysis of lipids such as fatty acids, oxygenated fatty acids, enantiomeric acyl- and alkylglycerols, and lipoproteins. The handbook also provides extensive coverage of applications of combinations of various chromatographic techniques used in the analysis of ozonides, anacardic acids, glycerophospholipids, products of lipolysis, artifacts and contaminants in edible fats, acylated proteins, non-caloric lipids, lipophilic vitamins, acyl-Coenzyme A thioesters, dolichols, mycolic acids, technical fats and fat products, and liposomes. Handbook of Chromatography: Analysis of Lipids will be a useful reference for oil chemists, biochemists, fat science technologists, and other scientists involved in lipid research.

Handbook Of Size Exclusion Chromatography And Related Techniques

Handbook Of Size Exclusion Chromatography And Related Techniques Book
Author : Chi-San Wu
Publisher : CRC Press
Release : 2003-11-04
ISBN : 0824757793
Language : En, Es, Fr & De

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Book Description :

Documenting critical advances in this rapidly evolving field, the Second Edition highlights the need for new applications and technologies that assist in the determination of molecular weight and molecular weight distributions of polymers in an accurate, efficient manner. This volume presents the latest findings from a international team of specialists and continues to inspire and extend practical applications of size exclusion chromatography (SEC). It includes six new chapters covering high-speed size exclusion chromatography, SEC of low molecular weight materials, and the extended family of techniques, from two-dimensional liquid chromatography to high osmotic pressure chromatography.

A Practical Handbook of Preparative HPLC

A Practical Handbook of Preparative HPLC Book
Author : Donald A Wellings
Publisher : Elsevier
Release : 2011-04-18
ISBN : 9780080458854
Language : En, Es, Fr & De

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Book Description :

This book is a distillation of twenty years of practical experience of the high pressure liquid chromatography (HPLC) process. Deliberately steering clear of complex theoretical aspects, this book concentrates on the everyday problems associated with the technique, making it perfect for frequent use in the laboratory and for those in the pharmaceutical, agrochemical and biotechnology industries for the analysis and purification of drugs, small molecules, proteins and DNA. This book... •Provides practical, hands-on advice based on years of experience •Will help ensure optimal design, equipment and separation results for your particular task •Presents system layouts from laboratory to process scale •Will help you to devise or improve record-keeping and documentation systems ·Provides practical, hands-on advice based on years of experience ·Will help ensure optimal design, equipment and separation results for your particular task ·Presents system layouts from laboratory to process scale ·Will help you to devise or improve record-keeping and documentation systems

Handbook of Thin Layer Chromatography

Handbook of Thin Layer Chromatography Book
Author : Joseph Sherma,Bernard Fried
Publisher : CRC Press
Release : 2003-04-18
ISBN : 0824748662
Language : En, Es, Fr & De

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Book Description :

In this third edition, more than 40 renowned authorities introduce and update chapters on the theory, fundamentals, techniques, and instrumentation of thin-layer chromatography (TLC) and high-performance thin-layer chromatography (HPTLC), highlighting the latest procedures and applications of TLC to 19 important compound classes and coverage of TLC applications by compound type. Easily adaptable to industrial scenarios , the Handbook of Thin-Layer Chromatography, Third Edition supports practical research strategies with extensive tables of data, offers numerous figures that illustrate techniques and chromatograms, and includes a glossary as well as a directory of equipment suppliers.

Expanded Bed Chromatography

Expanded Bed Chromatography Book
Author : B. Mattiasson
Publisher : Springer Science & Business Media
Release : 1999-12-31
ISBN : 9780792361237
Language : En, Es, Fr & De

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Book Description :

Expanded bed adsorption chromatography is a novel processing technique for the purification of biomolecules, combining clarification, concentration and initial purification in one step. By such an integration it is possible to reduce the number of steps in the purification process, to shorten the processing time and to improve the yields. The technology is new, and interesting developments have taken place concerning the adsorbents, the processing technology and potential applications. Both small-scale laboratory processes and larger industrial processes are being developed. Expanded bed chromatography is one of the most exciting new developments in downstream processing in recent years. The technology will be a standard procedure when new biotechnological processes are being developed.

Handbook of Affinity Chromatography

Handbook of Affinity Chromatography Book
Author : Toni Kline
Publisher : CRC Press
Release : 1993-06-16
ISBN : 9780824789398
Language : En, Es, Fr & De

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Book Description :

Outlining the fundamental principles by which all interactions occur, this reference focuses on harnessing the biochemistry of bioorganic compounds in order to separate them, presenting new techniques and applications that affect the planning of research strategies. The contributors discuss how to c

Analytical Instrumentation Handbook

Analytical Instrumentation Handbook Book
Author : Jack Cazes
Publisher : CRC Press
Release : 2004-11-30
ISBN : 9780849390395
Language : En, Es, Fr & De

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Book Description :

Compiled by the editor of Dekker's distinguished Chromatographic Science series, this reader-friendly reference is as a unique and stand-alone guide for anyone requiring clear instruction on the most frequently utilized analytical instrumentation techniques. More than just a catalog of commercially available instruments, the chapters are wri

CRC Handbook of Chromatography

CRC Handbook of Chromatography Book
Author : Henryk Lamparczyk
Publisher : CRC Press
Release : 1992-08-21
ISBN : 9780849330087
Language : En, Es, Fr & De

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Book Description :

CRC Handbook of Analysis and Characterization of Steroids provides a comprehensive review of chromatographic methods used in steroid analysis, including gas chromatography, high-performance liquid chromatography, thin-layer chromatography, and supercritical fluid chromatography. The book discusses principles, applications, and apparatus required for the chromatographic analysis of steroids. Classes of steroids covered include anabolic-androgenic steroids, bile acids, cardenolides, ecdysteroids, estrogens, corticoids, sterols, and Vitamin D. A chapter is devoted to each class of steroids and features nomenclature, structures, and descriptions for sample preparations and chromatographic data. CRC Handbook of Analysis and Characterization of Steroids provides essential information and techniques for professional analytical chemists in academia, clinical chemists in pharmaceutical and food quality control labs, and researchers and technicians in forensic and drug analysis facilities.

Handbook of Batch Process Design

Handbook of Batch Process Design Book
Author : P.N. Sharratt
Publisher : Springer Science & Business Media
Release : 1997-09-30
ISBN : 9780751403695
Language : En, Es, Fr & De

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Book Description :

Batch processes are used to manufacture many fine organic chemicals, and as such they can be considered to underpin much of the modern chemical industry. Despite widespread use and a consequent huge contribution to wealth creation, batch processes have attracted limited attention outside the user industries. Batch chemicals processing uses a number of core techniques and technologies, such as scheduling and sequence control, agitation and batch filtration. The combination of these technologies with often complex chemistry, the multi-purpose nature of much of this type of plant, the distinctive safety and environmental issues, and a fast moving commercial environment makes the development of a successful batch process a considerable challenge for the chemist or engineer. The literature on the topics covered in this book is fragmented and often not easily accessible, so this handbook has been written to address this problem and to bring together design and process analysis methods in the core areas of batch process design. By combining the science and pragmatism required in the development of successful batch processes this new book provides answers to real problems in an accessible and concise way. Written by an international team of authors drawn from industry, consulting and academe, this book is an essential part of the library of any chemist, technologist or engineer working on the development of new or existing batch processes.

Handbook of Membrane Separations

Handbook of Membrane Separations Book
Author : Anil Kumar Pabby,Syed S.H. Rizvi,Ana Maria Sastre Requena
Publisher : CRC Press
Release : 2008-07-07
ISBN : 1420009486
Language : En, Es, Fr & De

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Book Description :

The Handbook of Membrane Separations: Chemical, Pharmaceutical, and Biotechnological Applications provides detailed information on membrane separation technologies as they have evolved over the past decades. To provide a basic understanding of membrane technology, this book documents the developments dealing with these technologies. It explo

Handbook of Chemical and Biological Plant Analytical Methods 3 Volume Set

Handbook of Chemical and Biological Plant Analytical Methods  3 Volume Set Book
Author : Shilin Chen,Andrew Marston,Hermann Stuppner
Publisher : John Wiley & Sons
Release : 2014-07-15
ISBN : 1118874986
Language : En, Es, Fr & De

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Book Description :

Plants and plant-derived compounds and drugs are becoming moreand more popular with increasing numbers of scientists researchingplant analysis. The quality control of herbal drugs is alsobecoming essential to avoid severe health problems, and in thefuture many more new drugs will be developed from plantsources. This three-volume Handbook, featuring 47 detailed review articles,is unique as it deals with chemical and biological methodologiesfor plant analysis. It presents the most important and mostaccurate methods which are available for plant analysis. This comprehensive work is divided into six sections asfollows: Sample preparation and identification – discussingplant selection and collection, followed by extraction and samplepreparation methodologies. Extraction and sample preparation methodologies Instrumentation for chemical analysis - severalinstrumentations for chemical plant analysis are presented with anemphasis on hyphenated techniques, e.g. the coupling between HPLCand mass spectroscometry, and HPLC with NMR. Strategies for selective classes of compounds –coverage of the most interesting classes of compounds such aspolysaccharides, saponins, cardiotonic glycosides, alkaloids,terpenoids, lipids, volatile compounds and polyphenols (flavonoids, xanthones, coumarins, naphthoquinones, anthraquinones,proanthocyanidins, etc.). Biological Analysis - includes phenotyping, DNA barcodingtechniques, transcriptome analysis , microarray, metabolomics andproteomics. Drugs from Plants – covers the screening of plantextracts and strategies for the quick discovery of novelbioactive natural products. Safety assessment of herbal drugs ishighly dependent on outstanding chromatographic and spectroscopicmethods which are also featured here. This Handbook introduces to scientists involved in plant studiesthe current knowledge of methodologies in various fields ofchemically- and biochemically-related topics in plantresearch. The content from this Handbook will publish online within theEncyclopedia of Analytical Chemistry via Wiley Online Library: ahref="http://www.wileyonlinelibrary.com/ref/eac"http://www.wileyonlinelibrary.com/ref/eac/a Benefit from the introductory offer, valid until 30 November2014! Introductory price: £425.00 / $695.00 /€550.00 List price thereafter: £495.00 / $795.00 / €640.00

Handbook of Spectroscopy

Handbook of Spectroscopy Book
Author : G¿nter Gauglitz,David S. Moore
Publisher : John Wiley & Sons
Release : 2014-05-05
ISBN : 3527654720
Language : En, Es, Fr & De

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Book Description :

This second, thoroughly revised, updated and enlarged edition provides a straightforward introduction to spectroscopy, showing what it can do and how it does it, together with a clear, integrated and objective account of the wealth of information that may be derived from spectra. It also features new chapters on spectroscopy in nano-dimensions, nano-optics, and polymer analysis. Clearly structured into sixteen sections, it covers everything from spectroscopy in nanodimensions to medicinal applications, spanning a wide range of the electromagnetic spectrum and the physical processes involved, from nuclear phenomena to molecular rotation processes. In addition, data tables provide a comparison of different methods in a standardized form, allowing readers to save valuable time in the decision process by avoiding wrong turns, and also help in selecting the instrumentation and performing the experiments. These four volumes are a must-have companion for daily use in every lab.