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Handbook Of Pharmacogenomics And Stratified Medicine

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Handbook of Pharmacogenomics and Stratified Medicine

Handbook of Pharmacogenomics and Stratified Medicine Book
Author : Anonim
Publisher : Academic Press
Release : 2017-11-13
ISBN : 9780128100523
Language : En, Es, Fr & De

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Book Description :

"Handbook of Pharmacogenomics and Stratified Medicine" is a comprehensive resource to understand this rapidly advancing field aiming to deliver the right drug at the right dose to the right patient at the right time. It is designed to provide a detailed, but accessible review of the entire field from basic principles to applications in various diseases. The chapters are written by international experts to allow readers from a wide variety of backgrounds, clinical and non-clinical (basic geneticists, pharmacologists, clinicians, trialists, industry personnel, ethicists) to understand the principles underpinning the progress in this area, the successes, failures and the challenges ahead. Tobe accessibleto the widest range of readers, the clinical application section introduces the disease process, existing therapies, followed by pharmacogenomics and stratified medicine details. Medicine isthe cornerstone of modern therapeutics prescribed on the basis that its benefit should outweigh its risk. It is well known that people respond differently to medications and in many cases the risk-benefit ratio for a particular drug may be a gray area. The last decade has seen a revolution in genomics both in terms of technological innovation and discovering genetic markers associated with disease. In parallel there has been steady progress in trying to make medicines safer and tailored to the individual. This has occurred across the whole spectrum of medicine, some more than others. In addition there is burgeoning interest from the pharmaceutical industry to leverage pharmacogenomics for more effective and efficient clinical drug development. Provides clinical and non-clinical researchers with practical information normally beyond their usual areas of research or expertiseIncludes an basic principles section explaining concepts of basic genetics, genetic epidemiology, bioinformatics, pharmacokinetics and pharmacodynamicsCovers newer technologies next generation sequencing, proteomics, metabolomicsProvides information on animal models, lymphoblastoid cell lines, stem cells Provides detailed chapters on a wide range of disease conditions, implementation and regulatory issuesIncludes chapters on the global implications of pharmacogenomics"

Handbook of Pharmacogenomics and Stratified Medicine

Handbook of Pharmacogenomics and Stratified Medicine Book
Author : Sandosh Padmanabhan
Publisher : Academic Press
Release : 2014-04-28
ISBN : 0123868831
Language : En, Es, Fr & De

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Book Description :

Handbook of Pharmacogenomics and Stratified Medicine is a comprehensive resource to understand this rapidly advancing field aiming to deliver the right drug at the right dose to the right patient at the right time. It is designed to provide a detailed, but accessible review of the entire field from basic principles to applications in various diseases. The chapters are written by international experts to allow readers from a wide variety of backgrounds, clinical and non-clinical (basic geneticists, pharmacologists, clinicians, trialists, industry personnel, ethicists) to understand the principles underpinning the progress in this area, the successes, failures and the challenges ahead. To be accessible to the widest range of readers, the clinical application section introduces the disease process, existing therapies, followed by pharmacogenomics and stratified medicine details. Medicine is the cornerstone of modern therapeutics prescribed on the basis that its benefit should outweigh its risk. It is well known that people respond differently to medications and in many cases the risk-benefit ratio for a particular drug may be a gray area. The last decade has seen a revolution in genomics both in terms of technological innovation and discovering genetic markers associated with disease. In parallel there has been steady progress in trying to make medicines safer and tailored to the individual. This has occurred across the whole spectrum of medicine, some more than others. In addition there is burgeoning interest from the pharmaceutical industry to leverage pharmacogenomics for more effective and efficient clinical drug development. Provides clinical and non-clinical researchers with practical information normally beyond their usual areas of research or expertise Includes an basic principles section explaining concepts of basic genetics, genetic epidemiology, bioinformatics, pharmacokinetics and pharmacodynamics Covers newer technologies– next generation sequencing, proteomics, metabolomics Provides information on animal models, lymphoblastoid cell lines, stem cells Provides detailed chapters on a wide range of disease conditions, implementation and regulatory issues Includes chapters on the global implications of pharmacogenomics

Drug Design

Drug Design Book
Author : Arli Aditya Parikesit
Publisher : BoD – Books on Demand
Release : 2021-06-16
ISBN : 1789847524
Language : En, Es, Fr & De

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Book Description :

Right before the COVID-19 pandemic declared by the World Health Organization (WHO), life sciences have incited novel areas of studies that revolutionize the health sector. They are the studies of structural bioinformatics, pharmacogenomics, and metabolomics. The structural bioinformatics field is the very foundation of drug design research, as it provides insight into the molecular simulations and interactions between the biomolecules and the drug candidates. Secondly, pharmacogenomics is the starting point of any efforts in developing personalized medicine. Lastly, metabolomics provides instrumentation to elicit biomarkers for various diseases and health conditions. These studies have enabled current accelerated effort in COVID-19 research, as well as other communicable and non-communicable diseases.

Pharmacoepigenetics

Pharmacoepigenetics Book
Author : Anonim
Publisher : Academic Press
Release : 2019-06-04
ISBN : 0128139404
Language : En, Es, Fr & De

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Book Description :

Pharmacoepigenetics, Volume Eleven provides a comprehensive volume on the role of epigenetics and epigenomics in drug discovery and development, providing a detailed, but accessible, view of the field, from basic principles, to applications in disease therapeutics. Leading international researchers from across academia, clinical settings and the pharmaceutical industry discuss the influence of epigenetics and epigenomics in human pathology, epigenetic biomarkers for disease prediction, diagnosis, and treatment, current epigenetic drugs, and the application of epigenetic procedures in drug development. Throughout the book, chapter authors offer a balanced and objective discussion of the future of pharmacoepigenetics and its crucial contribution to the growth of precision and personalized medicine. Fully examines the influence of epigenetics and epigenomics in human pathology, epigenetic biomarkers for disease prediction, diagnosis, treatment, current epigenetic drugs and the application of epigenetic procedures in drug development Features chapter contributions from leading international researchers in academia, clinical settings and the pharmaceutical industry Instructs researchers, students and clinicians on how to better interpret and employ pharmacoepigenetics in drug development, efficiency and safety Provides a balanced and objective discussion of the future of pharmacoepigenetics and its crucial role in precision medicine

Big Data Pharmacogenomics and Real World Research in Pharmacology

Big Data  Pharmacogenomics and Real World Research in Pharmacology Book
Author : James Cheng-Chung Wei,Taisei Mushiroda,Wei-Chiao Chang
Publisher : Frontiers Media SA
Release : 2020-10-12
ISBN : 2889660664
Language : En, Es, Fr & De

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Book Description :

Download Big Data Pharmacogenomics and Real World Research in Pharmacology book written by James Cheng-Chung Wei,Taisei Mushiroda,Wei-Chiao Chang, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Personalized Psychiatry

Personalized Psychiatry Book
Author : Bernhard Baune
Publisher : Academic Press
Release : 2019-10-16
ISBN : 0128131772
Language : En, Es, Fr & De

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Book Description :

Personalized Psychiatry presents the first book to explore this novel field of biological psychiatry that covers both basic science research and its translational applications. The book conceptualizes personalized psychiatry and provides state-of-the-art knowledge on biological and neuroscience methodologies, all while integrating clinical phenomenology relevant to personalized psychiatry and discussing important principles and potential models. It is essential reading for advanced students and neuroscience and psychiatry researchers who are investigating the prevention and treatment of mental disorders. Combines neurobiology with basic science methodologies in genomics, epigenomics and transcriptomics Demonstrates how the statistical modeling of interacting biological and clinical information could transform the future of psychiatry Addresses fundamental questions and requirements for personalized psychiatry from a basic research and translational perspective

Textbook of Cultural Psychiatry

Textbook of Cultural Psychiatry Book
Author : Dinesh Bhugra,Kamaldeep Bhui
Publisher : Cambridge University Press
Release : 2018-02-28
ISBN : 1108683169
Language : En, Es, Fr & De

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Book Description :

Cultural psychiatry deals with the impact of culture on causation, perpetuation and treatment of patients suffering with mental illness. The role of culture in mental illness is increasingly being recognised, and the misconceptions that can occur as a result of cultural differences can lead to misdiagnoses, under or over-diagnosis. This second edition of the Textbook of Cultural Psychiatry has been completely updated with additional new chapters on globalisation and mental health, social media and tele-psychiatry. Written by world-leading experts in the field, this new edition provides a framework for the provision of mental health care in an increasingly globalised world. The first edition of the Textbook of Cultural Psychiatry was commended in the BMA Book Awards in 2008 and was the recipient of the 2012 Creative Scholarship Award from the Society for the Study of Psychiatry and Culture.

Food as Medicine

Food as Medicine Book
Author : Maurice M. Iwu
Publisher : CRC Press
Release : 2016-11-25
ISBN : 149870610X
Language : En, Es, Fr & De

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Book Description :

This comprehensive book documents African plants used for functional and medicinal foods. It contains more than 60 detailed monographs of African foods, describing foods with various characteristics such as prebiotic, probiotic, satiety, immune modulation, stress-reduction, sports performance, mental acuity, sleep-supporting, metabolic syndrome, antioxidant, and unsaturated fats. Plant description, botanical names and synonyms, plant part used, habitat and distribution, folk use, nutritional content, and chemistry are all fully detailed. The book highlights indigenous African food processing technologies up to the modern era.

Studies in Natural Products Chemistry

Studies in Natural Products Chemistry Book
Author : Anonim
Publisher : Elsevier
Release : 2018-08-31
ISBN : 0444641807
Language : En, Es, Fr & De

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Book Description :

Studies in Natural Products Chemistry, Volume 59, the latest in the series, covers the synthesis, or testing and recording, of the medicinal properties of natural products, providing cutting-edge accounts of fascinating developments in the isolation, structure elucidation, synthesis, biosynthesis and pharmacology of a diverse array of bioactive natural products. Natural products in the plant and animal kingdom offer a huge diversity of chemical structures that are the result of biosynthetic processes that have been modulated over the millennia through genetic effects. With the rapid developments in spectroscopic techniques and accompanying advances in high-throughput screening techniques, this book is a welcomed resource. Focuses on the chemistry of bioactive natural products Contains contributions by leading authorities in the field Presents sources of new pharmacophores

High Throughput Screening Methods

High Throughput Screening Methods Book
Author : Joshua A Bittker,Nathan T Ross
Publisher : Royal Society of Chemistry
Release : 2016-12-05
ISBN : 1782626778
Language : En, Es, Fr & De

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Book Description :

High throughput screening remains a key part of early stage drug and tool compound discovery, and methods and technologies have seen many fundamental improvements and innovations over the past 20 years. This comprehensive book provides a historical survey of the field up to the current state-of-the-art. In addition to the specific methods, this book also considers cultural and organizational questions that represent opportunities for future success. Following thought-provoking foreword and introduction from Professor Stuart Schreiber and the editors, chapters from leading experts across academia and industry cover initial considerations for screening, methods appropriate for different goals in small molecule discovery, newer technologies that provide alternative approaches to traditional miniaturization procedures, and practical aspects such as cost and resourcing. Within the context of their historical development, authors explain common pitfalls and their solutions. This book will serve as both a practical reference and a thoughtful guide to the philosophy underlying technological change in such a fast-moving area for postgraduates and researchers in academia and industry, particularly in the areas of chemical biology, pharmacology, structural biology and assay development.

Neuroanatomy of the Mouse

Neuroanatomy of the Mouse Book
Author : Hannsjörg Schröder,Natasha Moser,Stefan Huggenberger
Publisher : Springer Nature
Release : 2020-02-28
ISBN : 3030198987
Language : En, Es, Fr & De

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Book Description :

This textbook describes the basic neuroanatomy of the laboratory mouse. The reader will be guided through the anatomy of the mouse nervous system with the help of abundant microphotographs and schemata. Learning objectives and summaries of key facts at the beginning of each chapter provide the reader with an overview on the most important information. As transgenic mice are one of the most widely used paradigms when it comes to modeling human diseases, a basic understanding of the neuroanatomy of the mouse is of considerable value for all students and researchers in the neurosciences and pharmacy, but also in human and veterinary medicine. Accordingly, the authors have included, whenever possible, comparisons of the murine and the human nervous system. The book is intended as a guide for all those who are about to embark on the structural, histochemical and functional phenotyping of the mouse’s central nervous system. It can serve as a practical handbook for students and early researchers, and as a reference book for neuroscience lectures and laboratories.

Smart Nanotechnology with Applications

Smart Nanotechnology with Applications Book
Author : Cherry Bhargava,Amit Sachdeva,Pradeep Kumar Sharma
Publisher : CRC Press
Release : 2020-12-16
ISBN : 1000262480
Language : En, Es, Fr & De

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Book Description :

This comprehensive reference text discusses advance concepts and applications in the field of nanotechnology. The text presents a detailed discussion of key important concepts including nanomaterials and nanodevices, nano-bio interface, nanoscale memories, and semiconductor nanotechnology. It discusses applications of nanotechnology in the fields of aerospace engineering, cosmetic industry, pharmaceutical science, food industry, and the textile industry. The text will be useful for senior undergraduate and graduate students in the field of electrical engineering, electronics engineering, nanotechnology, and pharmaceutical science. Discussing fundamental, advanced concepts and their applications in a single volume, this text will be useful as a reference text for senior undergraduate and graduate students in the field of electrical engineering, electronics engineering, nanotechnology, and pharmaceutical science. It comprehensively discusses important concepts such as nano-robotics, carbon-based nanomaterials, and nanoscale memories. The text discusses advanced concepts of nanotechnology and its applications in the fields of textile, pharmaceutical sciences, aerospace, and food industry. It will be an ideal reference text for senior undergraduate and graduate students in the field of electrical engineering, electronics engineering, nanotechnology, and nanoscience.

Cardio Oncology

Cardio Oncology Book
Author : Roberta A. Gottlieb,Puja K Mehta
Publisher : Academic Press
Release : 2016-11-26
ISBN : 0128035536
Language : En, Es, Fr & De

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Book Description :

Cardio-Oncology: Principles, Prevention and Management is a clinical volume that focuses on the basic science of cardio-oncology, addresses cardiotoxicity as a consequence of cancer therapy, and discusses prevention, diagnosis and management of cardiovascular disease in patients with cancer. This comprehensive volume presents unique perspectives ranging from basic science to clinical medicine in the field of cardio-oncology. It would be a valuable resource for cardiologists, oncologists, internists, and pediatricians caring for patients with cancer who have cardiovascular risk factors, as well as for cardio-oncology researchers. Covers basic science of cardio-oncology to provide readers with the necessary background Addresses cardiotoxicity related to current cancer therapeutic modalities Discusses diagnostic and management approaches of patients with underlying cardiac risk factors as well as otherwise healthy cancer patients

Applications of Bioinformatics in Rice Research

Applications of Bioinformatics in Rice Research Book
Author : Manoj Kumar Gupta
Publisher : Springer Nature
Release : 2021-10-19
ISBN : 9811639973
Language : En, Es, Fr & De

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Book Description :

Download Applications of Bioinformatics in Rice Research book written by Manoj Kumar Gupta, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Omics Technologies for Sustainable Agriculture and Global Food Security Volume 1

Omics Technologies for Sustainable Agriculture and Global Food Security Volume 1 Book
Author : Anirudh Kumar
Publisher : Springer Nature
Release : 2021-10-19
ISBN : 9811608318
Language : En, Es, Fr & De

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Book Description :

Download Omics Technologies for Sustainable Agriculture and Global Food Security Volume 1 book written by Anirudh Kumar, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Sample Preparation in Metabolomics

Sample Preparation in Metabolomics Book
Author : Julia Kuligowski,Guillermo Quintás
Publisher : MDPI
Release : 2021-04-07
ISBN : 3039438131
Language : En, Es, Fr & De

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Book Description :

Metabolomics is increasingly being used to explore the dynamic responses of living systems in biochemical research. The complexity of the metabolome is outstanding, requiring the use of complementary analytical platforms and methods for its quantitative or qualitative profiling. In alignment with the selected analytical approach and the study aim, sample collection and preparation are critical steps that must be carefully selected and optimized to generate high-quality metabolomic data. This book showcases some of the most recent developments in the field of sample preparation for metabolomics studies. Novel technologies presented include electromembrane extraction of polar metabolites from plasma samples and guidelines for the preparation of biospecimens for the analysis with high-resolution μ magic-angle spinning nuclear magnetic resonance (HR-μMAS NMR). In the following chapters, the spotlight is on sample preparation approaches that have been optimized for diverse bioanalytical applications, including the analysis of cell lines, bacteria, single spheroids, extracellular vesicles, human milk, plant natural products and forest trees.

Forensic Medicine and Human Cell Research

Forensic Medicine and Human Cell Research Book
Author : Takaki Ishikawa
Publisher : Springer
Release : 2018-11-03
ISBN : 981132297X
Language : En, Es, Fr & De

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Book Description :

This volume reviews the application of biochemical and molecular pathologies, which are based on conventional pathomorphology, toxicology, and DNA analysis technologies, not only to autopsies but also to the field of clinical medicine in general. The systematic and integrated use of biochemical, immmunohistochemical, and molecular pathology, toxicology, DNA analysis, and cell culture investigations reinforces the pathophysiological diagnostic criteria in a forensic autopsy for clinical diagnosis. The use of these technologies can help to determine the cause and process of death and characterize the functional pathophysiological changes in the body that occur during the death process. Recently, the systematization of the latest supplemental tests, diagnostic methods, and quality control has allowed us to conduct comprehensive data collection and analysis for a range of diseases. This book presents the latest findings on the pathology of a broad range of human diseases, based on data concerning postmortem biochemistry and molecular biology collected from approximately 1000 people. Further, it puts forward a code of ethics for undertaking pathophysiological research and describes research techniques for uncovering pathophysiological mechanisms. As such, it offers a unique resource for researchers in the field of forensic medicine and pathology, and for clinicians. ​

The Genetics of African Populations in Health and Disease

The Genetics of African Populations in Health and Disease Book
Author : Muntaser E. Ibrahim,Charles N. Rotimi
Publisher : Cambridge University Press
Release : 2019-12-19
ISBN : 1107072026
Language : En, Es, Fr & De

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Book Description :

A pioneering work that focuses on the unique diversity of African genetics, offering insights into human biology and genetic approaches.

Bioinformatics Analysis of Single Cell Sequencing Data and Applications in Precision Medicine

Bioinformatics Analysis of Single Cell Sequencing Data and Applications in Precision Medicine Book
Author : Jialiang Yang,Liao Bo,Tuo Zhang,Yifei Xu
Publisher : Frontiers Media SA
Release : 2020-02-27
ISBN : 2889635287
Language : En, Es, Fr & De

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Book Description :

Download Bioinformatics Analysis of Single Cell Sequencing Data and Applications in Precision Medicine book written by Jialiang Yang,Liao Bo,Tuo Zhang,Yifei Xu, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Routledge Handbook of Medical Law and Ethics

Routledge Handbook of Medical Law and Ethics Book
Author : Yann Joly,Bartha Maria Knoppers
Publisher : Routledge
Release : 2014-09-19
ISBN : 1134448651
Language : En, Es, Fr & De

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Book Description :

This book explores the scope, application and role of medical law, regulatory norms and ethics, and addresses key challenges introduced by contemporary advances in biomedical research and healthcare. While mindful of national developments, the handbook supports a global perspective in its approach to medical law. Contributors include leading scholars in both medical law and ethics, who have developed specially commissioned pieces in order to present a critical overview and analysis of the current state of medical law and ethics. Each chapter offers comprehensive coverage of longstanding and traditional topics in medical law and ethics, and provides dynamic insights into contemporary and emerging issues in this heavily debated field. Topics covered include: Bioethics, health and human rights Medical liability Law and emerging health technologies Public health law Personalized medicine The law and ethics of access to medicines in developing countries Medical research in the genome era Emerging legal and ethical issues in reproductive technologies This advanced level reference work will prove invaluable to legal practitioners, scholars, students and researchers in the disciplines of law, medicine, genetics, dentistry, theology, and medical ethics.