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Handbook Of Pharmacogenomics And Precision Medicine

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Handbook of Personalized Medicine

Handbook of Personalized Medicine Book
Author : Ioannis S. Vizirianakis
Publisher : CRC Press
Release : 2014-02-12
ISBN : 9814411205
Language : En, Es, Fr & De

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Book Description :

This book compiles multidisciplinary efforts to conceptualize the environment in research and clinical setting that creates the fertile ground for the practical utility of personalized medicine decisions and also enables clinical pharmacogenomics for establishing pharmacotyping in drug prescription. Its covers innovative drug formulations and nanotheranostics, molecular imaging and signatures, translational nanomedicine and informatics, stem cell therapy approaches, modeling and predictability of drug response, pharmacogenetics-guided drug prescription, pediatric drug dosing, pharmacovigilance and regulatory aspects, ethical and cost-effectiveness issues, pharmacogenomics knowledge bases, personal genome sequencing, molecular diagnostics, as well as information-based medicine.

Handbook of Biomarkers and Precision Medicine

Handbook of Biomarkers and Precision Medicine Book
Author : Claudio Carini,Mark Fidock,Alain van Gool
Publisher : CRC Press
Release : 2019-04-16
ISBN : 0429574622
Language : En, Es, Fr & De

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Book Description :

"The field of Biomarkers and Precision Medicine in drug development is rapidly evolving and this book presents a snapshot of exciting new approaches. By presenting a wide range of biomarker applications, discussed by knowledgeable and experienced scientists, readers will develop an appreciation of the scope and breadth of biomarker knowledge and find examples that will help them in their own work." -Maria Freire, Foundation for the National Institutes of Health Handbook of Biomarkers and Precision Medicine provides comprehensive insights into biomarker discovery and development which has driven the new era of Precision Medicine. A wide variety of renowned experts from government, academia, teaching hospitals, biotechnology and pharmaceutical companies share best practices, examples and exciting new developments. The handbook aims to provide in-depth knowledge to research scientists, students and decision makers engaged in Biomarker and Precision Medicine-centric drug development. Features: Detailed insights into biomarker discovery, validation and diagnostic development with implementation strategies Lessons-learned from successful Precision Medicine case studies A variety of exciting and emerging biomarker technologies The next frontiers and future challenges of biomarkers in Precision Medicine Claudio Carini, Mark Fidock and Alain van Gool are internationally recognized as scientific leaders in Biomarkers and Precision Medicine. They have worked for decades in academia and pharmaceutical industry in EU, USA and Asia. Currently, Dr. Carini is Honorary Faculty at Kings’s College School of Medicine, London, UK. Dr. Fidock is Vice President of Precision Medicine Laboratories at AstraZeneca, Cambridge, UK. Prof.dr. van Gool is Head Translational Metabolic Laboratory at Radboud university medical school, Nijmegen, NL.

Handbook of Drug Monitoring Methods

Handbook of Drug Monitoring Methods Book
Author : Amitava Dasgupta
Publisher : Springer Science & Business Media
Release : 2007-10-23
ISBN : 1588297802
Language : En, Es, Fr & De

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Book Description :

In Handbook of Drug Monitoring Methods: Therapeutics and Drug Abuse, authors discuss the different analytical techniques used in today’s practice of therapeutic drug monitoring and drugs of abuse as well as alcohol testing with relevant theory, mechanism, and in-depth scientific discussion on each topic. This volume is the perfect handbook and quick reference for any clinical laboratory, allowing clinicians to find the potential source of a false-positive or a false-negative result in the daily operation of a toxicology laboratory. At the same time, this book can also be used as a reference for medical technologists, supervisors, laboratory directors, clinical chemists, toxicologists, and pathologists to find in-depth cause of a potential interference and what tests can be ordered to circumvent such problem. The volume’s first half focuses on various issues of therapeutic drug monitoring. Additional chapters cover analysis of heavy metals, alcohol testing, and issues of drugs of abuse testing. These chapters are written by experts in their relative sub-specialties and also by the editor. Comprehensive and timely, Handbook of Drug Monitoring Methods: Therapeutics and Drug Abuse is the ideal text for clinicians and researchers monitoring alcohol and drug testing and other important tasks of toxicological laboratory services.

Routledge Handbook of Medical Law and Ethics

Routledge Handbook of Medical Law and Ethics Book
Author : Yann Joly,Bartha Maria Knoppers
Publisher : Routledge
Release : 2014-09-19
ISBN : 1134448724
Language : En, Es, Fr & De

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Book Description :

This book explores the scope, application and role of medical law, regulatory norms and ethics, and addresses key challenges introduced by contemporary advances in biomedical research and healthcare. While mindful of national developments, the handbook supports a global perspective in its approach to medical law. Contributors include leading scholars in both medical law and ethics, who have developed specially commissioned pieces in order to present a critical overview and analysis of the current state of medical law and ethics. Each chapter offers comprehensive coverage of longstanding and traditional topics in medical law and ethics, and provides dynamic insights into contemporary and emerging issues in this heavily debated field. Topics covered include: Bioethics, health and human rights Medical liability Law and emerging health technologies Public health law Personalized medicine The law and ethics of access to medicines in developing countries Medical research in the genome era Emerging legal and ethical issues in reproductive technologies This advanced level reference work will prove invaluable to legal practitioners, scholars, students and researchers in the disciplines of law, medicine, genetics, dentistry, theology, and medical ethics.

Problem Solving through Precision Oncology

Problem Solving through Precision Oncology Book
Author : Peter Selby
Publisher : EBN Health, an imprint of Evidence-based Networks Ltd
Release : 2016-11-07
ISBN : 184692653X
Language : En, Es, Fr & De

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Book Description :

Winner of the BMA Oncology Book of the Year Award. This practical learning and reference handbook provides an overview of the latest progress in the developing field of precision oncology, plus a ground breaking collection of case studies ("Problems") showing precision oncology in practice. The book includes a clear, readable summary of developments, alongside real-life case studies, providing a valuable update for all involved in the oncology community. The editors lead research and clinical teams at four UK centres of excellence in the field.

Handbook of Anticancer Pharmacokinetics and Pharmacodynamics

Handbook of Anticancer Pharmacokinetics and Pharmacodynamics Book
Author : Michelle A. Rudek,Cindy H. Chau,William D. Figg,Howard L. McLeod
Publisher : Springer Science & Business Media
Release : 2014-01-10
ISBN : 1461491355
Language : En, Es, Fr & De

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Book Description :

There are many steps on the road from discovery of an anticancer drug to securing its final approval by the Food and Drug Administration. In this thoroughly updated and expanded second edition of the Handbook of Anticancer Pharmacokinetics and Pharmacodynamics, leading investigators synthesize an invaluable overview of the experimental and clinical processes of anticancer drug development, creating a single indispensable reference that covers all the steps from the identification of cancer-specific molecular targets to screening techniques and the development and validation of bioanalytical methods to clinical trial design and all phases of clinical trials. The authors have included new material on phase 0 trials in oncology, organ dysfunction trials, drug formulations and their impact on anticancer drug PK/PD including strategies to improve drug delivery, pharmacogenomics and cancer therapy, high throughput platforms in drug metabolism and transport pharmacogenetics, imaging in drug development and nanotechnology in cancer. Authoritative and up-to-date, Handbook of Anticancer Pharmacokinetics and Pharmacodynamics, 2nd Edition provides in one comprehensive and highly practical volume a detailed step-by-step guide to the successful design and approval of anticancer drugs. Road map to anticancer drug development from discovery to NDA submission Discussion of molecular targets and preclinical screening Development and validation of bioanalytical methods Chapters on clinical trial design and phase 0, I, II, III clinical trials Pharmacokinetics, pharmacodynamics, pharmacogenomics, and pharmacogenetics of anticancer agents Review of the drug development process from both laboratory and clinical perspectives New technological advances in imaging, high throughput platforms, and nanotechnology in anticancer drug development

Preclinical Development Handbook

Preclinical Development Handbook Book
Author : Shayne Cox Gad
Publisher : John Wiley & Sons
Release : 2008-03-21
ISBN : 9780470249048
Language : En, Es, Fr & De

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Book Description :

A clear, straightforward resource to guide you through preclinical drug development Following this book's step-by-step guidance, you can successfully initiate and complete critical phases of preclinical drug development. The book serves as a basic,comprehensive reference to prioritizing and optimizing leads, toxicity, pharmacogenomics, modeling, and regulations. This single definitive, easy-to-use resource discusses all the issues that need consideration and provides detailed instructions for current methods and techniques. Each chapter was written by one or more leading experts in the field. These authors, representing the many disciplines involved in preclinical toxicology screening and testing, give you the tools needed to apply an effective multidisciplinary approach. The editor, with more than thirty years' experience working with pharmaceutical and biotechnology companies, carefully reviewed all the chapters to ensure that each one is thorough, accurate, and clear. Among the key topics covered are: * In vitro mammalian cytogenetics tests * Phototoxicity * Carcinogenicity studies * The pharmacogenomics of personalized medicine * Bridging studies * Toxicogenomics and toxicoproteomics Each chapter offers a full exploration of problems that may be encountered and their solutions. The authors also set forth the limitations of various methods and techniques used in determining the safety and efficacy of a drug during the preclinical stage. This is a hands-on guide for pharmaceutical scientists involved in preclinical testing,enabling them to perform and document preclinical safety tests to meet all FDA requirements before clinical trials may begin.

Textbook of Personalized Medicine

Textbook of Personalized Medicine Book
Author : Kewal K. Jain
Publisher : Springer Science & Business Media
Release : 2009-08-29
ISBN : 9781441907691
Language : En, Es, Fr & De

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Book Description :

Personalized medicine, which simply means selection of treatment best suited for an individual, involves integration and translation of several new technologies in clinical care of patients. The scope is much broader than indicated by the term genomic medicine because many non-genomic factors are taken into consideration in developing personalized medicine. Basic technologies for personalized medicine, of which molecular diagnostics has the biggest share, are mentioned briefly and appropriate references are given for further information. Commercial aspects are discussed briefly in a chapter and detailed analysis of markets and companies involved in personalized medicine is presented in a special report on this topic. There is increasing interest in personalized medicine. Considerable advances have taken place in molecular biology and biotechnology to make personalized medicine a viable option, but some misconceptions still exist, both in the academic and commercial sectors. There is lack of a suitable source of information that provides both the fundamentals as well as applications of personalized medicine. As the latest version of the first monograph on personalized medicine published in 1998, this volume, Textbook of Personalized Medicine, summarizes the author’s efforts during the past decade, as well as reviews selected studies done during this period in a readable format for the physicians and scientists. It is hoped that physicians, pharmacists, scientists and interested lay readers with basic scientific knowledge will find this book useful.

The Handbook of Biomarkers

The Handbook of Biomarkers Book
Author : Kewal K. Jain
Publisher : Springer Science & Business Media
Release : 2010-02-06
ISBN : 9781607616856
Language : En, Es, Fr & De

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Book Description :

Of the thousands of biomarkers that are currently being discovered, relatively few are being validated for further applications, and the potential of a biomarker can be quite difficult to evaluate. To aid in this imperative research, Dr. Kewal K. Jain’s Handbook of Biomarkers thoroughly describes many different types of biomarkers and their discovery using various "-omics" technologies, such as proteomics and metabolomics, along with the background information needed for the evaluation of biomarkers as well as the essential procedures for their validation and use in clinical trials. With biomarkers described first according to technologies and then according to various diseases, this detailed book features the key correlations between diseases and classifications of biomarkers, which provides the reader with a guide to sort out current and future biomarkers. Comprehensive and cutting-edge, The Handbook of Biomarkers serves as a vital guide to furthering our understanding of biomarkers, which, by facilitating the combination of therapeutics with diagnostics, promise to play an important role in the development of personalized medicine, one of the most important emerging trends in healthcare today.

Mastering Pharmacogenomics A Nurse s Handbook for Success

Mastering Pharmacogenomics  A Nurse s Handbook for Success Book
Author : Dale Halsey Lea,Dennis J. Cheek,Daniel Brazeau,Gayle Brazeau
Publisher : Sigma Theta Tau
Release : 2015-01-14
ISBN : 1938835700
Language : En, Es, Fr & De

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Book Description :

Pharmacogenomics, the study of the role of genetics in drug response, has developed into a critical new area in battling disease and improving outcomes. As our knowledge of the human genome grows, and with the advent of next-generation sequencing technologies, the role of genetic research is evolving to guide therapy and prevent many diseases and mitigate side-effects of current treatments. As a pivotal member of the healthcare team, nurses must acquire competency in pharmacogenomics to deliver optimal patient care in the 21st century. Mastering Pharmacogenomics provides nursing professionals with a foundational knowledge of human genetics and genomics that can be applied in optimizing drug therapy and patient care delivery. Coverage includes: Essential pharmacogenomics competencies for registered nurses Genomics technologies and resources Critical properties of drug response and disposition Covered specialties include obstetrics and prenatal patients, pediatrics, older adult patients, and oncology Ethics and patient careFuture developments in technology and delivery

Handbook of Pharmaceutical Biotechnology

Handbook of Pharmaceutical Biotechnology Book
Author : Shayne C. Gad
Publisher : Wiley-Interscience
Release : 2007-06-11
ISBN :
Language : En, Es, Fr & De

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Book Description :

Describes the use of biotechnology to develop pharmaceuticals. This book gives the professional a basic tool to facilitate the development of biotech medicines by bringing together a general overview of biotechnology used in the drug development process, along with a compendium of regulations and validation methods.

Handbook of Basic Pharmacokinetics Including Clinical Applications

Handbook of Basic Pharmacokinetics   Including Clinical Applications Book
Author : Wolfgang A. Ritschel,Gregory L. Kearns,American Pharmaceutical Association
Publisher : Amer Pharmacists Assn
Release : 2004
ISBN :
Language : En, Es, Fr & De

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Book Description :

A user-friendly handbook on the principles and techniques involved in the various applications of pharmacokinetics. Provides a concise reference for clinicians who need quick information on the pharmacokinetic characteristics of specific drugs. Thoroughly updated and revised, this book features pharmacokinetic data profiles on more than 600 drugs.

Handbook of Communication in Oncology and Palliative Care

Handbook of Communication in Oncology and Palliative Care Book
Author : David Kissane,Barry Bultz,Phyllis Butow,Ilora Finlay
Publisher : OUP Oxford
Release : 2011-03-31
ISBN : 0191620815
Language : En, Es, Fr & De

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Book Description :

This comprehensive text provides clinicians with practical and evidence-based guidelines to achieve effective, patient-centered communication in the areas of cancer and palliative care. Written by an outstanding panel of international experts, it integrates empirical findings with clinical wisdom, draws on historical approaches and presents a state-of-the-art curriculum for applied communication skills training for the specialist oncologist, surgeon, nurse and other multi-disciplinary team members involved in cancer care today. In this book communication is broken down into key modules that cover the life-cycle of cancer care. They include coverage of diagnosis and treatment including clinical trials, empathic support in response to distress, transition to survivorship or palliative therapies, discussion of prognosis, conduct of family meetings, and care of the dying. Complementary training of patients in their communication with the doctor completes the interactive dyad. The art of teaching, impact of gender and power in the consultation and the ethical context are carefully considered. Special communication challenges include discussion of genetic risk, rehabilitative and salvage surgery, promotion of treatment adherence, unanticipated adverse outcomes, intercultural issues, fertility and sexuality. The value of decision aides, question prompt lists, audio-recording of consultations and use of the internet is illustrated. By looking across the full spectrum of disciplines involved in the multidisciplinary team, discipline-specific issues are considered by experts in each field. In this manner, the needs of patients and their relatives are evaluated, including paediatric and geriatric populations. To achieve all of this, theoretical models are examined from the medical school to the highly specialized practice, facilitation training and actor training are made explicit, and international approaches to communication skills training are compared and contrasted. Finally, research tools that assist in coding cancer consultations, evaluating training courses, and employing mixed methods in studies aid the reader in providing clear and sensitive communication when handling challenging situations whilst treating cancer sufferers and palliative care patients.

Handbook of Spectroscopy

Handbook of Spectroscopy Book
Author : G¿nter Gauglitz,David S. Moore
Publisher : John Wiley & Sons
Release : 2014-05-05
ISBN : 3527654720
Language : En, Es, Fr & De

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Book Description :

This second, thoroughly revised, updated and enlarged edition provides a straightforward introduction to spectroscopy, showing what it can do and how it does it, together with a clear, integrated and objective account of the wealth of information that may be derived from spectra. It also features new chapters on spectroscopy in nano-dimensions, nano-optics, and polymer analysis. Clearly structured into sixteen sections, it covers everything from spectroscopy in nanodimensions to medicinal applications, spanning a wide range of the electromagnetic spectrum and the physical processes involved, from nuclear phenomena to molecular rotation processes. In addition, data tables provide a comparison of different methods in a standardized form, allowing readers to save valuable time in the decision process by avoiding wrong turns, and also help in selecting the instrumentation and performing the experiments. These four volumes are a must-have companion for daily use in every lab.

Handbook of Drug Screening Second Edition

Handbook of Drug Screening  Second Edition Book
Author : Ramakrishna Seethala,Litao Zhang
Publisher : CRC Press
Release : 2009-06-24
ISBN :
Language : En, Es, Fr & De

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Book Description :

A presentation of screening techniques, modern technologies, and high-capacity instrumentation for increased productivity in the development and discovery of new drugs, chemical compounds, and targeted delivery of pharmaceuticals. It contains practical applications and examples of strategies in cell-based and cell-free screens as well as homogeneous, fluorescence, chemiluminescence, and radioactive-based technologies.

Biomarkers in Drug Development

Biomarkers in Drug Development Book
Author : Michael R. Bleavins,Claudio Carini,Mallé Jurima-Romet,Ramin Rahbari
Publisher : John Wiley & Sons
Release : 2011-09-20
ISBN : 1118210425
Language : En, Es, Fr & De

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Book Description :

Discover how biomarkers can boost the success rate of drugdevelopment efforts As pharmaceutical companies struggle to improve the success rateand cost-effectiveness of the drug development process, biomarkershave emerged as a valuable tool. This book synthesizes and reviewsthe latest efforts to identify, develop, and integrate biomarkersas a key strategy in translational medicine and the drugdevelopment process. Filled with case studies, the bookdemonstrates how biomarkers can improve drug development timelines,lower costs, facilitate better compound selection, reducelate-stage attrition, and open the door to personalizedmedicine. Biomarkers in Drug Development is divided into eightparts: Part One offers an overview of biomarkers and their role in drugdevelopment. Part Two highlights important technologies to help researchersidentify new biomarkers. Part Three examines the characterization and validation processfor both drugs and diagnostics, and provides practical advice onappropriate statistical methods to ensure that biomarkers fulfilltheir intended purpose. Parts Four through Six examine the application of biomarkers indiscovery, preclinical safety assessment, clinical trials, andtranslational medicine. Part Seven focuses on lessons learned and the practical aspectsof implementing biomarkers in drug development programs. Part Eight explores future trends and issues, including dataintegration, personalized medicine, and ethical concerns. Each of the thirty-eight chapters was contributed by one or moreleading experts, including scientists from biotechnology andpharmaceutical firms, academia, and the U.S. Food and DrugAdministration. Their contributions offer pharmaceutical andclinical researchers the most up-to-date understanding of thestrategies used for and applications of biomarkers in drugdevelopment.

Handbook of Research in Mobile Business

Handbook of Research in Mobile Business Book
Author : Bhuvan Unhelkar
Publisher : IGI Global
Release : 2006
ISBN :
Language : En, Es, Fr & De

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Book Description :

This two-volume collection of 63 comprehensive chapters brings together the practical experiences and knowledge of researchers and academics, making it the single most significant contribution on understanding the usage and application of mobile technologies and networks in global business.

Pharmacogenomics and Proteomics

Pharmacogenomics and Proteomics Book
Author : Steven How-Yan Wong,Mark W. Linder,Roland Valdes
Publisher : AACC Press
Release : 2006
ISBN :
Language : En, Es, Fr & De

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Book Description :

Reviews the fundamentals of molecular biology and general clinical implications important in understanding fundamental concepts, a general review of ethical considerations, methods of predicting response using artificial networks, regulatory issues, reimbursement, quality assurance considerations, and future market analysis; methodologies that merge the disciplines of pharmacogenetics with those of proteomics, metabolomics, and metabonomics; specific clinical applications of pharmacogenetics of major drug groups, specialties, and diseases, and how they are linked to potential clinical management; and selected biotechnologies relevant to the application of clinical pharmacogenomics and proteomics to clinical practice.

Pharmacogenomics An Introduction and Clinical Perspective

Pharmacogenomics An Introduction and Clinical Perspective Book
Author : Joseph S. Bertino,Angela Kashuba,Joseph D. Ma,C. Lindsay DeVane,Uwe Fuhr
Publisher : McGraw Hill Professional
Release : 2012-10-09
ISBN : 0071741690
Language : En, Es, Fr & De

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Book Description :

Pharmacogenomics is comprehensive textbook detailing how genetic makeup affects a body's response to drugs.

Cardiovascular Genetics and Genomics

Cardiovascular Genetics and Genomics Book
Author : Dhavendra Kumar,Perry Elliott
Publisher : Springer
Release : 2018-01-17
ISBN : 3319661140
Language : En, Es, Fr & De

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Book Description :

This title reflects the exponential growth in the knowledge and information on this subject and defines the extensive clinical translation of cardiovascular genetics and genomics in clinical practice. This concise, clinically oriented text is targeted at a broad range of clinicians who manage patients and families with a wide range of heterogeneous inherited cardiovascular conditions. Cardiovascular Genetics and Genomics: Principles and Clinical Practice includes a concise and clear account on selected topics written by a team of leading experts on clinical cardiovascular genetics. Each chapter include key information to assist the clinician and case histories have been incorporated to reflect contemporary practice in clinical cardiovascular genetics and genomics. Therefore this will be of key importance to all professionals working in the discipline, from clinicians and trainees in cardiology, cardiac surgery, electrophysiology, immunology through geneticists, nursing staff and those involved in precision medicine.