Handbook Of Neuroemergency Clinical Trials

Book Description :

Handbook of Neuroemergency Clinical Trials, Second Edition, focuses on the practice of clinical trials in acute neuroscience populations, or what have been called neuroemergencies. Neuroemergencies are complex, life-threatening diseases and disorders, often with devastating consequences, including death or disability. The overall costs are staggering in terms of annual incidence and costs associated with treatment and survival, yet despite their significance as public health issues, there are few drugs and devices available for definitive treatment. The book focuses on novel therapies and the unique challenges their intended targets pose for the design and analysis of clinical trials. This volume provides neurologists, neuroscientists, and drug developers with a more complete understanding of the scientific and medical issues of relevance in designing and initiating clinical development plans for novel drugs intended for acute neuroscience populations. The editors provide the best understanding of the pitfalls associated with acute CNS drug development and the best information on how to approach and solve issues that have plagued drug development. Presents a comprehensive overview on clinical trials and drug development challenges in acute neuroscience populations Provides neurologists, neuroscientists and drug developers with a complete understanding of scientific and medical issues related to designing clinical trials Edited by leaders in the field who have designed and managed over 50 neuroemergency clinical trials

Book Description :

Handbook of Neuroemergency Clinical Trials, 2e focuswa on the "state of the practice" of clinical trials in acute neuroscience populations, or what have been called "neuroemergencies." Neuroemergencies are complex life-threatening diseases and disorders, often with devastating consequences including death or disability. The overall costs are staggering in terms of annual incidence and costs associated with treatment and survival from acute neurological emergencies. Yet, despite their significance as public health issues, there are few drugs and devices available for definitive treatment The book focuses on novel therapies and the unique challenges their intended targets pose for the design and analysis of clinical trials. This volume provides neurologists, neuroscientists, and drug developers with a more complete understanding of the scientific and medical issues of relevance in designing and initiating clinical development plans for novel drugs intended for acute neuroscience populations. The editors provide the best understanding of the pitfalls associated with acute CNS drug development and the best information available regarding how to approach and solve the issues that have plagued drug development. Comprehensive overview on clinical trials and drug development challenges in acute neuroscience populations Provides neurologists, neuroscientists, and drug developers with a complete understanding of scientific and medical issues related to designing clinical trials Edited by leaders in the field who have designed and managed over 50 neuroemergency clinical trials

Book Description :

This is the first comprehensive guide to the design of behavioral randomized clinical trials (RCT) for chronic diseases. It includes the scientific foundations for behavioral trial methods, problems that have been encountered in past behavioral trials, advances in design that have evolved, and promising trends and opportunities for the future. The value of this book lies in its potential to foster an ability to “speak the language of medicine” through the conduct of high-quality behavioral clinical trials that match the rigor commonly seen in double-blind drug trials. It is relevant for testing any treatment aimed at improving a behavioral, social, psychosocial, environmental, or policy-level risk factor for a chronic disease including, for example, obesity, sedentary behavior, adherence to treatment, psychosocial stress, food deserts, and fragmented care. Outcomes of interest are those that are of clinical significance in the treatment of chronic diseases, including standard risk factors such as cholesterol, blood pressure, and glucose, and clinical outcomes such as hospitalizations, functional limitations, excess morbidity, quality of life, and mortality. This link between behavior and chronic disease requires innovative clinical trial methods not only from the behavioral sciences but also from medicine, epidemiology, and biostatistics. This integration does not exist in any current book, or in any training program, in either the behavioral sciences or medicine.

Book Description :

This practical handbook allows nurses, advanced practice nurses, physician assistants, and allied health professionals practicing in the fields of neurosurgery, neurology, and spinal care to quickly review essentials while in the work environment. It emphasizes procedural steps and critical elements in patient management, including intensive care, the neurological examination, differential diagnoses, and pain management. Written by a multidisciplinary team of experts, the handbook is expected to become a well-worn companion and essential aid to the busy practitioner.

Book Description :

Good neurosurgical practice is based not only on evidence, skills, and modern equipment, but also on good values. This book is the first to discuss specifically the ethical issues that arise during the daily practice of neurosurgery. It is divided into three parts addressing patients’ rights, ethical issues relating to the working environment, and wider societal aspects such as dealings of neurosurgeons with the legal system, the media, and companies. The authors are well-established neurosurgeons who present the ethical problems that they have encountered during their careers and explain what they have learned in confronting these problems. In all, more than 50 neurosurgical cases drawn from real life are reported and discussed from an ethical point of view. This book will be especially informative for young neurosurgeons and will provide all who work in this very special field with a road map on how to avoid violations of medical ethics in neurosurgical practice.

Book Description :

Covering the many relatively uncommon pain conditions that are often misdiagnosed, this one-of-a-kind visual resource clearly presents the extensive knowledge and experience of world-renowned pain expert Steven D. Waldman, MD, JD. Atlas of Uncommon Pain Syndromes, 4th Edition, first and foremost helps you make a correct diagnosis – a critical step in managing patients in chronic pain. Hundreds of high-quality illustrations, as well as x-rays, ultrasound, CTs, and MRIs, help you confirm your diagnoses with confidence. Offers head-to-toe coverage – 135 conditions in all – providing concise, easy-to-read chapters for each condition. Dr. Waldman’s practical guidance is designed to help you make the correct diagnosis of uncommon pain syndromes, even the signs and symptoms don’t quite fit. Explains each pain syndrome using a consistent, easy-to-follow format: an ICD-10 CM code for billing purposes, followed by a brief description of the signs and symptoms, laboratory and radiographic testing, differential diagnosis, available treatment options, and clinical pearls. Features updated chapters throughout, as well as 12 new chapters covering Hemicrania Continua, Acute Calcific Prevertebral Tendinitis, Sternohyoid Syndrome Snapping Scapula Syndrome, Erythromelagia, Foix-Alajouanine Syndrome, Lumbar Paraspinous Muscle Compartment Syndrome, Clunealgia, Nutcracker Syndrome, Paroxysmal Extreme Pain Disorder, Iliopsoas Tendon Rupture, and Snapping Pes Anserinus Syndrome Provides practitioners and trainees in pain medicine, anesthesiology, neurology, psychiatry, physical medicine and rehabilitation, primary care, and more with a firm foundation in the diagnosis of uncommon pain in daily practice.

Book Description :

Download American Book Publishing Record book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Book Description :

Noted pain authority Dr. Steven Waldman returns with a new edition of Atlas of Common Pain Syndromes. Delivering complete, concise, step-by-step visual guidance, this innovative, popular atlas equips you to effectively diagnose and manage pain syndromes commonly encountered in any clinical practice. Clearly labeled, vivid illustrations depict the physical symptoms and anatomy of each pain site, and diagnostic images demonstrate key findings from MRI, CT, and conventional radiography. With an easy-to use, templated format, you’ll have Dr. Waldman’s preferred approaches right at your fingertips. Accurately diagnose and treat common pain syndromes by following a step-by-step approach that progresses from signs and symptoms through physical findings, laboratory and radiographic testing, treatment options, clinical pearls, and diagnostic codes. Practice with confidence by consulting with Steven D. Waldman, MD - author of numerous groundbreaking pain management references - as well as a team of leading international authorities. Quickly and easily find the information you need thanks to highly templated chapters that explore signs and symptoms, physical findings, laboratory and radiographic testing, treatment options, clinical pearls, and diagnostic codes for each pain syndrome. Ensure proper reimbursement with comprehensive coverage of insurance coding information. Avoid potential pitfalls in diagnosis and treatment by referring to "Side Effects and Complications" sections in each chapter. See, identify, and diagnose patients’ issues with help from clinically relevant illustrations that connect pain syndromes to clearly labeled anatomic illustrations. Effectively apply the latest techniques and approaches with 29 new chapters covering subarachnoid hemorrhage, adhesive capsulitis, iliopectineal bursitis, discitis, and more!

Book Description :

Download Joyce in the Belly of the Big Truck Workbook book written by Joyce A. Cascio, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Book Description :

Download The British National Bibliography book written by Arthur James Wells, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Book Description :

This text/reference book provides the most comprehensive coverage of anticholinesterase compounds (Organophosphates and Carbamates), which constitute the largest number of chemicals that are primarily used as insecticides in agriculture, industry, and around the home/garden. Some OPs (nerve agents) have been used in chemical warfare and terrorist attacks, while some OPs and CMs have been recommended as therapeutic agents in human medicine as well as in veterinary medicine. Many chemicals of both classes are extremely toxic and lack selectivity, thus their inadvertent/accidental use continues to pose a threat to human and animal health, aquatic systems and wildlife. These anticholinesterase agents produce a variety of toxicological effects in target and nontarget organs. In light of this complexicity, this multi-authored book is written by the well known scientists from many countries. The book is organized into nine sections, with a total of 49 chapters, to provide in-depth knowledge on various aspects of OP and CM compounds, including their use, classification, mechanism-based toxicity, and prophylactic and therapeutic measurements. Several chapters are written with special emphasis to cover timely topics, such as chemical warfare agents, physiologically-based pharmacokinetic modeling, structure and function of cholinesterases, paraoxonase, carboxylesterases; developmental neurotoxicity, the intermediate syndrome, oxidative stress, endocrine disruption, and DNA damage/gene expression and carcinogenesis. Section-VI with 5 chapters is specifically devoted to risk assessment, and safety and regulatory guidelines for pesticides. Describes everything you need to know about Organophosphates and Carbamates Extensively covers pesticides, nerve agents, therapeutic drugs, and flame retardants Describes epidemiology of the world's major disasters involving Organophosphates and Carbamates Covers animal, human, aquatic, and wildlife toxicity of Anticholinesterases Insights into in-depth cholinergic and noncholinergic mechanisms of toxicity Describes recent advancements in cholinesterases, paraoxonases, carboxylesterases, oxidative stress, endocrine disruption, cardiac and pulmonary toxicity, and carcinogenesis Provides in vitro and in vivo models for neurotoxicity testing Integrates knowledge of studies in lab animals and humans Offers risk/safety assessment and national/international guidelines for permissible levels of pesticide residues Describes management of Anticholinesterase poisoning in humans

Book Description :

Using diagrams and CT images, this easy-to-read Handbook offers clinicians a practical system for interpreting an emergency cranial CT scan.

Book Description :

This open access book offers an essential overview of brain, head and neck, and spine imaging. Over the last few years, there have been considerable advances in this area, driven by both clinical and technological developments. Written by leading international experts and teachers, the chapters are disease-oriented and cover all relevant imaging modalities, with a focus on magnetic resonance imaging and computed tomography. The book also includes a synopsis of pediatric imaging. IDKD books are rewritten (not merely updated) every four years, which means they offer a comprehensive review of the state-of-the-art in imaging. The book is clearly structured and features learning objectives, abstracts, subheadings, tables and take-home points, supported by design elements to help readers navigate the text. It will particularly appeal to general radiologists, radiology residents, and interventional radiologists who want to update their diagnostic expertise, as well as clinicians from other specialties who are interested in imaging for their patient care.

Book Description :

This updated second edition of Acute Ischemic Stroke: Imaging and Intervention provides a comprehensive account of the state of the art in the diagnosis and treatment of acute ischemic stroke. The basic format of the first edition has been retained, with sections on fundamentals such as pathophysiology and causes, imaging techniques and interventions. However, each chapter has been revised to reflect the important recent progress in advanced neuroimaging and the use of interventional tools. In addition, a new chapter is included on the classification instruments for ischemic stroke and their use in predicting outcomes and therapeutic triage. All of the authors are internationally recognized experts and members of the interdisciplinary stroke team at the Massachusetts General Hospital and Harvard Medical School. The text is supported by numerous informative illustrations, and ease of reference is ensured through the inclusion of suitable tables. This book will serve as a unique source of up-to-date information for neurologists, emergency physicians, radiologists and other health care providers who care for the patient with acute ischemic stroke.

Book Description :

This new book deals systematically with the assessment and treatment of small animal neurological patients in light of latest research findings and greatly improved imaging techniques. The authors first discuss step-wise neurological and systemic approaches to common emergency cases-examination, critical care and rapid assessment-based on presentin

Book Description :

The book provides detailed information on all major neuroemergencies, and includes a detailed checklist for practical care during the first hour of an emergency. Reinforcing the concept of quality care for better outcomes in patients with neurological diseases, the book discusses approaches to comatose patients, neurological evaluation, neuropharmacology, neuroradiology, traumatic brain and spine injury, and various other neurological disorders. The field of neuroanesthesiology and neurocritical care has expanded with the advent of newer, complex surgeries, and neurocritical care is becoming an established subspecialty of neuroscience. Neurological emergencies require special care since prevention of secondary damage to the brain is of paramount importance. A valuable resource for intensivists, neurointensivists, emergency medicine physicians, neurology and neurosurgeons and nursing professionals involved in neurocare, this book also serves as study material for participants of the two-day course on “Acute Neuro Care” designed by the Indian Society of Neuroanesthesiology and Critical Care (ISNACC).

Book Description :

Neurological Emergencies in Clinical Practice discusses neurological emergencies in a stepwise fashion including stabilizing the patient, identifying the cause, and treating the underlying cause. It is useful in several settings including the emergency room, hospital in-patient service as well as the intensive care unit. Neurological Emergencies in Clinical Practice has a wide appeal and relevance to disciplines including neurology, emergency medicine, critical care medicine, internal medicine and family medicine. Medical students and residents may use this convenient, pocket-sized book to prepare for and succeed in their training examinations and it is also useful for other house staff and practicing physicians.

Book Description :

Vestibular Disorders, Third Edition, uses a case-study approach to outline the principles and practice of the care of patients with dizziness and balance disorders. The text reflects the combined perspectives and experience of a neurologist (Dr. Furman) a neurotologic surgeon (Dr. Cass), and a physical therapist (Dr. Whitney). Each case study contains relevant material regarding history, physical examination, laboratory testing, differential diagnosis, and treatment. This material provides a springboard for discussion of either a concept in the field of vestibular disorders or the diagnosis or treatment of a particular disease state. Practical, specific treatment options are discussed throughout the book. The book is written to a wide audience and educational level of readers including Primary Care Physicians, Otolaryngologists, Neurologists, Physical Therapist, and Audiologists. The case-format style of the book lends itself to use in teaching programs involving medical students, residents, physical therapy students, and audiology students, and as a reference text for clinicians at the bedside. Each of the cases from the first and second editions have been updated, the background material has been expanded and eight new cases have been added. Vestibular Disorders, Third Edition, aims to span the gap between existing in-depth tests and the problems that arise whenever a patient presents with dizziness.

Book Description :

Emergency nursing requires rapid assessment and decision-making. Often nurses are required to make sense of considerable amounts of information and act on it. The Oxford Handbook of Emergency Nursing provides an essential resource when time is short and the need for practical clinical guidance is paramount. This second edition has been fully updated to reflect new guidelines and approaches which have impacted emergency nursing in recent years. This handbook provides clear, focussed information that will aid all areas of patient assessment and management in emergency care. The concise format will enable the reader to quickly locate the information needed and provides alerts regarding critical 'must-dos' for ill adults and children. The skills section provides a quick summary of the many clinical skills needed in emergency care, ideal as an introduction for the uninitiated and as a refresher for skills performed infrequently. Additionally, this second edition has been expanded to cover nursing in major trauma and emergencies in the elderly. This handbook will empower nurses to deliver excellence in emergency care. Written by practising nurses and subject experts, the Oxford Handbook of Emergency Nursing is a unique and invaluable companion for qualified and student nurses, and to all health care professionals working in the emergency care setting.

Book Description :

The story has been sculptured at the backdrop of scenic beauty in a typical Indian village with overwhelming farming community. It develops current reluctance of people to transform into the nuances of the modern world naturally embedded in the story. A twist to highlight the impoverished views of the society on casteism and agony faced by a girl and her parents during the marriage had been picturized. This then graduates to the evils of female feticide and unethical medical practices. Further, it develops into the male chauvinism in administration of religious places. The misinformation about Down syndrome is brought out and that of lack of attention given by parents and father on a challenged female child is painted. Illegal methods to terminate pregnancy have also been injected without confusion. Thereafter, lack of attention given to school buses and poor state of affairs in that sector is brought out and simulated into an accident. This is then graduated to give an insight in emergency evacuation and treatment. Finally, the subject of brain death and organ transplantation has been brought in.