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Growth Factors And Their Receptors In Cell Differentiation Cancer And Cancer Therapy

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Growth Factors and Their Receptors in Cell Differentiation Cancer and Cancer Therapy

Growth Factors and Their Receptors in Cell Differentiation  Cancer and Cancer Therapy Book
Author : Gajanan V. Sherbet
Publisher : Elsevier
Release : 2011
ISBN : 0123878195
Language : En, Es, Fr & De

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Book Description :

Annotation G.V. Sherbet provides insights into the signalling processes involved in morphogenesis and pathogenesis with emphasis on using the elements of the signalling cascades as targets for therapeutic deployment. The book focuses on the relationships and convergence of growth factors and their receptors in development and pathogenesis.

Growth Factors and Their Receptors in Cell Differentiation Cancer and Cancer Therapy

Growth Factors and Their Receptors in Cell Differentiation  Cancer and Cancer Therapy Book
Author : Gajanan V. Sherbet
Publisher : Unknown
Release : 2011-07-28
ISBN : 9780323165310
Language : En, Es, Fr & De

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Book Description :

Recent years have seen a considerable emphasis on growth factors and the elucidation of their mode of function, which has led to the recognition that growth factors, their receptors as well as downstream elements of signalling associated with their function might be potential targets in therapeutic management of human diseases. Humanised monoclonal antibodies raised against growth factor receptors have proved to be valuable for targeted cancer treatment and in patient management. This book reviews the latest developments providing insights into the signalling processes involved in morphogenesis and pathogenesis with emphasis on using the elements of the signalling cascades as targets for therapeutic deployment. Provides a fundamental understanding of the basic functions of growth factors and their receptors, describing how they are linked in biological processes Aids the development of therapeutic treatments for cancer Focuses on the interrelationships and convergence of growth factors and their receptors in development and pathogenesis and encourages greater cooperation and integration in the areas of developmental, cancer and cancer therapeutic research

Growth Factors and their Receptors in Cancer Metastasis

Growth Factors and their Receptors in Cancer Metastasis Book
Author : Wen G. Jiang,K. Matsumoto,T. Nakamura
Publisher : Springer Science & Business Media
Release : 2006-04-11
ISBN : 0306483998
Language : En, Es, Fr & De

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Book Description :

about the involvement of signaling Transforming growth factor in tumor development and metastasis. plays a central role in the signaling network that controls morphogenesis, 2. THE BASICS OF growth and cell differentiation in SIGNALING multicellular organisms. The different members of this pleiotropic family of 2. 1. receptor signaling growth and differentiation factors seem to The family of growth factors regulate many processes in human disease consists of more than thirty members in and, in particular, tumor development. humans alone (15, 16). They cluster in Our understanding of how two major groups, the group composed of initiated signals are mediated has both the bone morphogenetic proteins increased dramatically in the last fifteen (BMP) and growth and differentiation years. Firstly, the prototype of factors (GDFs), and the group formed by this still constantly growing family, was the Activins, and Nodals. The two identified and cloned (1). Secondly, the groups differ in their use of receptors for family receptors were transmembrane receptors and the identified by expression cloning from subsequent activation of the mammalian tissue culture (2-7). Thirdly, transcriptional mediators (for recent genetic screens in Drosophila reviews see (13, 14, 17)).

Growth Factors and Their Receptors in Cell Differentiation Cancer and Cancer Therapy

Growth Factors and Their Receptors in Cell Differentiation  Cancer and Cancer Therapy Book
Author : G V Sherbet
Publisher : Elsevier
Release : 2011-07-12
ISBN : 0123878209
Language : En, Es, Fr & De

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Book Description :

Recent years have seen a considerable emphasis on growth factors and the elucidation of their mode of function, which has led to the recognition that growth factors, their receptors as well as downstream elements of signalling associated with their function might be potential targets in therapeutic management of human diseases. Humanised monoclonal antibodies raised against growth factor receptors have proved to be valuable for targeted cancer treatment and in patient management. This book reviews the latest developments providing insights into the signalling processes involved in morphogenesis and pathogenesis with emphasis on using the elements of the signalling cascades as targets for therapeutic deployment. Provides a fundamental understanding of the basic functions of growth factors and their receptors, describing how they are linked in biological processes Aids the development of therapeutic treatments for cancer Focuses on the interrelationships and convergence of growth factors and their receptors in development and pathogenesis and encourages greater cooperation and integration in the areas of developmental, cancer and cancer therapeutic research

Molecular Approach to Cancer Management

Molecular Approach to Cancer Management Book
Author : Gajanan V. Sherbet
Publisher : Academic Press
Release : 2017-06-15
ISBN : 0128128976
Language : En, Es, Fr & De

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Book Description :

Molecular Approach to Cancer Management discusses molecular mechanisms of cancer initiation, growth and secondary spread, emphasizing how this information can be used to devise new modes of treatment of cancer, especially in combatting secondary spread. The book addresses the basic concepts relating to cancer biology, the genetic determinants, and the signal transduction cascades associated with tumor growth, EMT, stem cell maintenance and propagation, and invasion and metastasis. The salient features of the signaling systems that are amenable to targeted manipulation are emphasized to facilitate research and development in the design of novel therapies and for the planning of new trials. This book is the only unique volume with coverage of topics that target therapy. As such, it is a valuable source for cancer researchers, molecular oncologists and members of the biomedical field who are interested in knowing more about molecular approaches to cancer therapy. Covers all relevant topics with a defined aim of targeted therapy Encompasses the basic aspects of cancer invasion and metastasis Discusses signaling systems operating in normal cells and their deregulation in cancer cells Directs attention to the foci in signaling systems that can be targeted with a new and conventional drug-based approach

Therapeutic Strategies in Cancer Biology and Pathology

Therapeutic Strategies in Cancer Biology and Pathology Book
Author : Gajanan V. Sherbet
Publisher : Elsevier
Release : 2013-07-26
ISBN : 0124165907
Language : En, Es, Fr & De

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Book Description :

Currently, intensive effort is being directed toward the identification of molecular targets that can provide approaches to the development of novel therapeutic strategies in cancer management. This book focuses on metastasis-associated genes, metastasis promoter and suppressor genes, which relate specifically to behavioral alterations of cancer cells in epithelial mesenchymal transition, cancer stem cell maintenance and propagation, and to the acquisition of invasive and metastasis faculty. The function of these genes has implications for cell cycle regulation and cell proliferation and so constitute an essential element in cancer growth and dissemination. The emphasis in this book is on how appropriate these genes are as molecular targets and how practicable are the constituents of their signal transduction systems as potential candidates and how accessible they are to targeted therapy. Written in a straightforward and clear style with background information supporting the new research, this book will be useful for students and researchers in cancer therapies. Identifies molecular targets and their accessibility for therapeutic intervention Provides information on biological features of tumor development and dissemination Background information provided for each topic

The Genetics of Cancer

The Genetics of Cancer Book
Author : Gajanan V. Sherbet,M. S. Lakshmi
Publisher : Academic Press
Release : 1997-06-22
ISBN : 9780080542485
Language : En, Es, Fr & De

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Book Description :

Written by internationally recognized experts, The Genetics of Cancer provides up-to-date information and insight into the genetic basis of cancer and the mechanisms involved in cancer invasion and its secondary spread. This volume presents the deregulation of the cell cycle in tumor development and integrates the function of tumor suppressor genes, oncogenes, and metastasis-associated genes in the pathogenesis and progression of cancer. The Genetics of Cancer will be useful to all graduate students, clinicians, and researchers working in the fields of cancer biology, genetics, and molecular biology. Clonal evolution of the metastasis phenotype Cell Cycle regulation Apoptosis in tumour growth and metastasis Angiogenesis in cancer Cell surface glycoproteins and their receptors Proteinases and their inhibitors in cancer invasion Oncogenes and cancer metastasis Developmental genes Tumour suppressor genes Metastasis suppressor genes Dominant metastasis-associated genes

Genetic Recombination in Cancer

Genetic Recombination in Cancer Book
Author : Gajanan V. Sherbet
Publisher : Elsevier
Release : 2003-07-24
ISBN : 9780080521909
Language : En, Es, Fr & De

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Book Description :

Genetic recombination is a process of combining genes that leads to the generation of cell variants that possess different characteristics. This process is important to the evolution of a species and to embryonic growth and differentiation. However, this process can also lead to the development of abnormal, cancerous cells. This book reviews the role of genetic recombination in the generation of various cancers and how genetic alterations have been or could be employed to elicit clinically useful information. * Provides detailed discussion of the genetic mechanisms that result in the generation of normal and abnormal cells * Examines the role of genetic recombination in cancer including cancer invasion and metastasis * Information is presented in a manner that is useful and accessible to everyone from graduate students to established cancer researchers

Fibroblast Growth Factors Biology And Clinical Application Fgf Biology And Therapeutics

Fibroblast Growth Factors  Biology And Clinical Application   Fgf Biology And Therapeutics Book
Author : Simons Michael
Publisher : World Scientific
Release : 2016-12-27
ISBN : 981314338X
Language : En, Es, Fr & De

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Book Description :

The fibroblast growth factor (FGF) family of ligands and the corresponding family of FGF receptor tyrosine kinases comprise one of the most versatile and diverse growth factor signaling families in vertebrates, found virtually in every tissue and cell type where they regulate metabolic and physiologic function, maintain tissue homeostasis, and mediate injury response, tissue repair, and regeneration. As a result, FGFs play critical roles in a wide variety of normal biological and abnormalities in FGF signaling can lead to a variety of disease states from developmental malformations, to atherosclerosis, pulmonary hypertension and cancer among many others. A thorough understanding of this system is necessary for critical insights into both normal and disease biology and is essential to development of rationale therapeutic strategies aimed at treatment of FGF-dependent diseases states. Recent years have seen advances in our understanding of FGFs role in endothelial and, more general, vascular biology, the subject of this book. In particular, FGFs have been implicated in the maintenance of vascular homeostasis and control of blood vessel permeability while aberrant FGF signaling has been shown to be central to the development of pulmonary hypertension, and endothelial-to-mesenchymal transition, a process implicated in the development of atherosclerosis. Finally, FGFs ability to stimulate blood vessel growth has been explored in therapeutic angiogenesis approaches. With this in mind, the present monograph is structured to provide comprehensive information to a reader interested in FGFs in general and vascular biology in particular. To this end, we explore everything from the structure and signaling of FGFs and their receptors (Chapters 1, 2 and 3) to their role in the regulation of vascular homeostasis (Chapter 4) and cardiovascular diseases (Chapters 5 and 6). We then address new developments in FGF therapeutics (chapter 7) and explore FGF biology in the epithelium (Chapter 8) thereby providing a complete analysis of this growth factor family biology in two closely related but distinctly different environments — endothelium and epithelium. Finally, we examine FGF biology in eye disease and in cancer. It is our hope that this comprehensive treatment of FGF vascular biology and its application will provide the reader with the accurate and timely summary of this rapidly moving field.

Insulin Like Growth Factors

Insulin Like Growth Factors Book
Author : Douglas Yee
Publisher : IOS Press
Release : 2003
ISBN : 9781586034092
Language : En, Es, Fr & De

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Book Description :

Over the past five years there has been an explosion of "targeted therapies" for cancer treatment. In most cases, these therapies have been based on pre-clinical data showing that specific molecules play an important role in regulating the malignant phenotype. In breast cancer, there is compelling rationale that such targeted strategies should be successful. Targeting of estrogen receptor ? (ER?) has proven to be a successful way to reduce breast cancer risk, decrease the risk of death and recurrence in an adjuvant setting, and remains the first choice of treatment for advanced disease. With this success, it is hoped that other molecular pathways could also be successfully exploited. This publication reviews the role of the insulin-like growth factors (IGFs) in breast cancer. Over 100 years ago George Beatson made an intuitive leap connecting breast cancer therapy with ovarian function He removed the ovaries from a premenopausal woman with breast cancer; he reasoned that ovarian function regulated normal mammary gland function, therefore the ovaries may influence the malignant phenotype. Other discussion included cover the function of IGF action in the normal mammary gland using mouse model systems where expression and function can be manipulated and the patterns of expression of the IGFs, their binding proteins, and their receptors in the normal gland.

Principles of Tumors

Principles of Tumors Book
Author : Leon P. Bignold
Publisher : Academic Press
Release : 2019-11-01
ISBN : 0128173297
Language : En, Es, Fr & De

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Book Description :

Principles of Tumors: A Translational Approach to Foundations, Second Edition, provides a concise summary of translational/interdisciplinary topics on the various aspects of tumors, especially abnormalities in their cells, their causes and effects on patients. Topics discussed include how genomic abnormalities in tumors may result from the actions of carcinogens and how genomic changes determine the cell biological/morphological abnormalities in tumor cell populations. In addition, the relationships between tumor cell genomics and therapeutic outcomes are described. There are also supporting appendices on general bioscience, including the principles of histology (the cells and tissues of the body), genetics, pathology, radiology and pharmacology. This book gives a thorough, detailed, yet concise account of the main bioscience, clinical and therapeutic aspects of tumors. It emphasizes the translational aspects of research into tumors with extensive discussions of interdisciplinary issues. The content in this book will be invaluable for researchers and clinicians involved in collaborative projects where it is necessary to understand fundamental issues in other branches of biomedicine. Presents content that has been totally updated with the most recent developments of the field, including new chapters on tumor imaging exams, new surgical techniques, immunotherapy, gene therapy, and several novel therapies using natural and synthetic compounds Presents translational approaches for every topic to improve conceptual insights for new research projects Covers a broad range of subjects, making it easier for the reader to understand related fields Includes diagrams for complex topics to aid in understanding for non-specialists

Protooncogenes and Growth Factors in Steroid Hormone Induced Growth and Differentiation

Protooncogenes and Growth Factors in Steroid Hormone Induced Growth and Differentiation Book
Author : Sohaib A. Khan,George M. Stancel
Publisher : CRC Press
Release : 1993-12-17
ISBN : 9780849386725
Language : En, Es, Fr & De

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Book Description :

Protooncogenes and Growth Factors in Steroid Hormone Induced Growth and Differentiation reviews current information regarding the complex nature of hormone-induced cell growth and differentiation. The contributors examine the emerging consensus that protooncogenes and growth factors mediate perhaps the most crucial steps leading to cell growth and differentiation. The primary objective of this book is to unite the status of current research related to protooncogenes and growth factors from diverse physiological systems to help readers gain a comprehensive understanding of the subject. Leading researchers have contributed outstanding chapters pertaining to steroid hormone-regulated cell growth and differentiation in normal and/or neoplastic tissues. This book will appeal to basic science researchers, clinicians, industrial researchers, and graduate students.

Transforming Growth Factor Beta in Cancer Therapy Volume II

Transforming Growth Factor Beta in Cancer Therapy  Volume II Book
Author : Sonia B. Jakowlew
Publisher : Springer Science & Business Media
Release : 2010-01-01
ISBN : 1597452939
Language : En, Es, Fr & De

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Book Description :

Transforming Growth Factor- ß in Cancer Therapy, Vols. 1 and 2, provides a compendium of findings about the role of transforming growth factor- ß (TGF- ß) in cancer treatment and therapy. The second volume, Cancer Treatment in Therapy, is divided into three parts. The companion volume details the role of TGF- ß on basic and clinical biology.

Growth Factors and Oncogenes

Growth Factors and Oncogenes Book
Author : M. Bolla,E. M. Chambaz,C. Vrousos
Publisher : Unknown
Release : 1989
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

The major objective of this book is to bring together specialists well-known for their contribution to the basic knowledge of growth factors and oncogenes and experts engaged in clinical research and prospective in cancer therapy."

Insulin like Growth Factor Receptor Signalling

Insulin like Growth Factor Receptor Signalling Book
Author : Derek Leroith,Walter Zumkeller,Robert C. Baxter
Publisher : Springer Science & Business Media
Release : 2003-07-31
ISBN : 9780306478468
Language : En, Es, Fr & De

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Book Description :

Insulin-like growth factors are ubiquitously expressed and are crucial for growth and function of almost all cells. Together with their binding proteins and receptors, they form a widely studied biological system involving many proteins and characterized by complex interactions. In addition to its significance in growth and development, the insulin-like growth factor system also has important roles in a wide variety of pathological states. This has led to interest in the therapeutic potential of insulin-like growth factors and their binding proteins as candidate drug targets. This comprehensive book contains current information on both basic science and clinical aspects of IGFs and their regulatory proteins, with emphasis on their relevance to cancer.

Signal Transduction in Cancer

Signal Transduction in Cancer Book
Author : David A. Frank
Publisher : Springer Science & Business Media
Release : 2006-04-18
ISBN : 0306481588
Language : En, Es, Fr & De

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Book Description :

One of the most exciting areas of cancer research now is the development of agents which can target signal transduction pathways that are activated inappropriately in malignant cells. The understanding of the molecular abnormalities which distinguish malignant cells from their normal counterparts has grown tremendously. This volume summarizes the current research on the role that signal transduction pathways play in the pathogenesis of cancer and how this knowledge may be used to develop the next generation of more effective and less toxic anticancer agents. Series Editor comments: "The biologic behavior of both normal and cancer cells is determined by critical signal transduction pathways. This text provides a comprehensive review of the field. Leading investigators discuss key molecules that may prove to be important diagnostic and/or therapeutic targets."

Transforming Growth Factor Beta in Cancer Therapy Volume I

Transforming Growth Factor Beta in Cancer Therapy  Volume I Book
Author : Sonia B. Jakowlew
Publisher : Springer Science & Business Media
Release : 2010-01-01
ISBN : 1597452920
Language : En, Es, Fr & De

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Book Description :

Transforming Growth Factor- ß in Cancer Therapy, Vols. 1 and 2, provides a compendium of findings about the role of transforming growth factor- ß (TGF- ß) in cancer treatment and therapy. The first volume, Basic and Clinical Biology, is divided into three parts. This volume’s companion, Cancer Treatment in Therapy, examines transforming growth factor- ß in other developing and advanced cancers and methods of treatment and therapy.

Transforming Growth Factor Beta in Cancer Therapy Volume II

Transforming Growth Factor Beta in Cancer Therapy  Volume II Book
Author : Sonia B. Jakowlew
Publisher : Humana Press
Release : 2010-10-28
ISBN : 9781617377365
Language : En, Es, Fr & De

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Book Description :

Transforming Growth Factor- ß in Cancer Therapy, Vols. 1 and 2, provides a compendium of findings about the role of transforming growth factor- ß (TGF- ß) in cancer treatment and therapy. The second volume, Cancer Treatment in Therapy, is divided into three parts. The companion volume details the role of TGF- ß on basic and clinical biology.

The Effects of Insulin Like Growth Factors on Human G292 Osteosarcoma Cells

The Effects of Insulin Like Growth Factors on Human G292 Osteosarcoma Cells Book
Author : Thabet AlHousami
Publisher : Unknown
Release : 2017
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Introduction: Osteosarcoma is the most common bone sarcoma in children and adolescents. It is an aggressive primary bone cancer recognized by abnormal cell proliferation and function. The insulin-like growth factor (IGF) system plays an integral role in the growth, differentiation, and developmental processes, and is involved in various physiological and pathological events. The IGF system consists of IGF I and II, their cell surface receptors and insulin-like growth factor binding proteins (IGFBP). IGF-binding proteins (IGFBPs) are important modulators of IGF signaling. IGF-II is a potent mitogen whose deregulation is linked to diverse pathologies and plays a role in tumorigenesis, development of different types of cancers such as liver, breast and prostate cancers, metastasis and resistance to existing forms of cancer therapy. Chromeceptin is a synthetic small molecule that induces expression of IGF inhibitory genes.^It has been shown that chromeceptin inhibits insulin-induced adipogenesis and decreases the growth and viability of hepatocellular carcinoma cells that overexpress IGF-II. The involvement of IGF-II and IGFBP1 in cancer suggests that the analysis of their regulation may provide us with a better understanding of human cancers and new therapeutic approaches. Aim of the study: To study the effect of IGF-II on the activity of human G292 osteosarcoma cells, focusing both on the effects of endogenous and exogenous IGF-II levels. In addition, to study the role of IGFBPs and chromeceptin on G292 osteosarcoma cell activity. Material and Methods: The MTT assay was used to assess the activity of G292 (Clone A141B1) human osteosarcoma cells. Growth activity was analyzed after various periods of incubation in serum-free media. Enzyme-linked Immunosorbent Assays (ELISA) were used to detect the endogenous levels of IGF-II and IGFBP1 in the treated G292 human osteosarcoma cells. Result: Our experimental results show that chromeceptin plays a significant role in the activity of G292 osteosarcoma cells, since chromeceptin alone decreased cell activity of G292 osteosarcoma cells compared to the control group. With the concentrations of IGF-II added exogenously, very small effects were observed under the conditions studied. G292 cells appear to thrive in serum free medium and to be dependent in an autocrine manner on IGF-II and paracrine effects of this growth factor are minimal. In addition, we tested the effects of chromeceptin on IGFBP-1 in G292 cells and observed significant decreases in IGF-II levels. At concentrations that had significant effects on G292 cell activity and IGF-II levels, chromeceptin produced small, but significant increases in IGFBP1 levels. Conclusions: Our studies with the drug, chromeceptin, presented here strongly suggest a role of endogenous IGF-II in cell activity of G292 human osteosarcoma cells with a role of IGFBP-1 in this process as well. In general, our studies on the involvement of IGF-II in the human G292 osteosarcoma cell suggest that the further analysis of IGF-II regulation may lead to a better understanding of human bone cancers and possible new cancer therapies.

Introduction to Biological and Small Molecule Drug Research and Development

Introduction to Biological and Small Molecule Drug Research and Development Book
Author : null Hasmann
Publisher : Elsevier Inc. Chapters
Release : 2013-05-07
ISBN : 0128061995
Language : En, Es, Fr & De

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Book Description :

HER2 (ErbB-2) is a member of the human epidermal growth factor receptor tyrosine kinase family which is involved in the regulation of cell proliferation, survival and differentiation. Soon after its discovery, HER2 was shown frequently to be overexpressed in breast cancer and was associated with a worse prognosis. It was identified as a target for drug development and molecular cloning of the gene and expression in cell lines provided a vehicle for the selection of HER2-specific antibodies. The monoclonal antibody trastuzumab is the first HER2-targeting drug approved for cancer treatment. By significantly extending the time to disease progression and overall survival of patients, it has become established in all treatment lines of early and metastatic HER2-positive breast cancer, as well as in HER2-positive advanced metastatic gastric or gastroesophageal junction cancer. Combination of trastuzumab with pertuzumab, a second antibody binding to a distinct epitope on HER2 which implies a different mode of action, took the treatment of HER2-positive metastatic breast cancer to the next level of success. Finally, trastuzumab emtansine is an antibodydrug conjugate that retains all pharmacodynamic activities of trastuzumab and delivers a toxic maytansinoid directly to the tumour cells. Current clinical results indicate that trastuzumab emtansine may be more efficacious and less toxic than trastuzumab plus chemotherapy, and further improvement is expected in combination with pertuzumab.