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Green Approaches In Medicinal Chemistry For Sustainable Drug Design

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Green Approaches in Medicinal Chemistry for Sustainable Drug Design

Green Approaches in Medicinal Chemistry for Sustainable Drug Design Book
Author : Bimal K. Banik
Publisher : Advances in Green Chemistry
Release : 2020-04
ISBN : 0128175923
Language : En, Es, Fr & De

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Book Description :

Extensive experimentation and high failure rates are a well-recognised downside to the drug discovery process, with the resultant high levels of inefficiency and waste producing a negative environmental impact. Sustainable and Green Approaches in Medicinal Chemistry reveals how medicinal and green chemistry can work together to directly address this issue. After providing essential context to the growth of green chemistry in relation to drug discovery in Part 1, the book goes on to identify a broad range of practical methods and synthesis techniques in Part 2. Part 3 reveals how medicinal chemistry techniques can be used to improve efficiency, mitigate failure and increase the environmental benignity of the entire drug discovery process, whilst Parts 4 and 5 discuss natural products and microwave-induced chemistry. Finally, the role of computers in drug discovery is explored in Part 6.

Contemporary Chemical Approaches for Green and Sustainable Drugs

Contemporary Chemical Approaches for Green and Sustainable Drugs Book
Author : Marianna Torok
Publisher : Elsevier
Release : 2022-08-26
ISBN : 0128232714
Language : En, Es, Fr & De

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Book Description :

Contemporary Chemical Approaches for Green and Sustainable Drugs provides readers with the knowledge they need to integrate sustainable approaches into their work. Sections cover different aspects of green and sustainable drug development from design to disposal, including computer-aided drug design, green resourcing of drugs and drug candidates, an overview of the health concerns of pharmaceutical pollution, and a survey of potential chemical methods for its reduction. Drawing together the knowledge of a global team of experts, this book provides an inclusive overview of the chemical tools and approaches available for minimizing the negative environmental impact of current and newly developed drugs. This will be a useful guide for all academic and industrial researchers across green and sustainable chemistry, medicinal chemistry, environmental chemistry and pharmaceutical science. Provides an integrative overview of the environmental risks of drugs and drug by products to support chemists in pre-emptively addressing these issues Highlights the advantages of computer-aided drug design, green and sustainable sourcing, and novel methods for the production of safer, more effective drugs Presents individual chapters written by renowned experts with diverse backgrounds Reflects research in practice through selected case studies and extensive state-of-the-art reference sections to serve as a starting point in the design of any specialized environmentally-conscious medicinal chemistry project

Green Approaches in Medicinal Chemistry for Sustainable Drug Design

Green Approaches in Medicinal Chemistry for Sustainable Drug Design Book
Author : Bimal K. Banik
Publisher : Elsevier
Release : 2020-03-27
ISBN : 0128175931
Language : En, Es, Fr & De

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Book Description :

Extensive experimentation and high failure rates are a well-recognised downside to the drug discovery process, with the resultant high levels of inefficiency and waste producing a negative environmental impact. Sustainable and Green Approaches in Medicinal Chemistry reveals how medicinal and green chemistry can work together to directly address this issue. After providing essential context to the growth of green chemistry in relation to drug discovery in Part 1, the book goes on to identify a broad range of practical methods and synthesis techniques in Part 2. Part 3 reveals how medicinal chemistry techniques can be used to improve efficiency, mitigate failure and increase the environmental benignity of the entire drug discovery process, whilst Parts 4 and 5 discuss natural products and microwave-induced chemistry. Finally, the role of computers in drug discovery is explored in Part 6. Identifies novel and cost effective green medicinal chemistry approaches for improved efficiency and sustainability Reflects on techniques for a broad range of compounds and materials Highlights sustainable and green chemistry pathways for molecular synthesis

Green and Sustainable Medicinal Chemistry

Green and Sustainable Medicinal Chemistry Book
Author : Louise Summerton,Helen F. Sneddon,Leonie C. Jones,James H. Clark
Publisher : Royal Society of Chemistry
Release : 2016
ISBN : 1782624678
Language : En, Es, Fr & De

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Book Description :

Download Green and Sustainable Medicinal Chemistry book written by Louise Summerton,Helen F. Sneddon,Leonie C. Jones,James H. Clark, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Green Chemistry in the Pharmaceutical Industry

Green Chemistry in the Pharmaceutical Industry Book
Author : Peter J. Dunn,Andrew Wells,Michael T. Williams
Publisher : John Wiley & Sons
Release : 2010-02-02
ISBN : 9783527629695
Language : En, Es, Fr & De

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Book Description :

Edited by three of the world's leading pharmaceutical scientists, this is the first book on this important and hot topic, containing much previously unpublished information. As such, it covers all aspects of green chemistry in the pharmaceutical industry, from simple molecules to complex proteins, and from drug discovery to the fate of pharmaceuticals in the environment. Furthermore, this ready reference contains several convincing case studies from industry, such as Taxol, Pregabalin and Crestor, illustrating how this multidisciplinary approach has yielded efficient and environmentally-friendly processes. Finally, a section on technology and tools highlights the advantages of green chemistry.

Green Techniques for Organic Synthesis and Medicinal Chemistry

Green Techniques for Organic Synthesis and Medicinal Chemistry Book
Author : Wei Zhang,Berkeley W. Cue
Publisher : John Wiley & Sons
Release : 2012-07-23
ISBN : 0470711515
Language : En, Es, Fr & De

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Book Description :

Green chemistry is a new way of looking at organic synthesis and the design of drug molecules, offering important environmental and economic advantages over traditional synthetic processes. Pharmaceutical companies are increasingly turning to the principles of green chemistry in an effort to reduce waste, reduce costs and develop environmentally benign processes. Green Techniques for Organic Synthesis and Medicinal Chemistry presents an overview of the established and emerging techniques in green organic chemistry, highlighting their applications in medicinal chemistry. The book is divided into four parts: Introduction: Introduces the reader to the toxicology of organic chemicals,their environmental impact, and the concept of green chemistry. Green Catalysis: Covers a variety of green catalytic techniques including organocatalysis, supported catalysis, biocatalysis, fluorous catalysis, and catalytic direct C-H bond activation reactions. Green Synthetic Techniques: Presents a series of new techniques, assessing the green chemistry aspects and limitations (i.e. cost, equipment, expertise). Techniques include reactions in alternative solvents, atom economic multicomponent reactions, microwave and ultrasonic reactions, solid-supported synthesis, fluorous and ionic liquid-based recycling techniques, and flow reactors. Green Techniques in Pharmaceutical Industry: Covers applications of green chemistry concepts and special techniques for medicinal chemistry, including synthesis, analysis, separation, formulation, , and drug delivery. Process and business case studies are included to illustrate the applications in the pharmaceutical industry. Green Techniques for Organic Synthesis and Medicinal Chemistry is an essential resource on green chemistry technologies for academic researchers, R&D professionals and students working in organic chemistry and medicinal chemistry.

Green Toxicology

Green Toxicology Book
Author : Alexandra Maertens
Publisher : Royal Society of Chemistry
Release : 2022-02-16
ISBN : 1839164409
Language : En, Es, Fr & De

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Book Description :

Green toxicology is an integral part of green chemistry. One of the key goals of green chemistry is to design less toxic chemicals. Therefore, an understanding of toxicology and hazard assessment is important for any chemist working in green chemistry, but toxicology is rarely part of most chemists' education. As a consequence, chemists lack the toxicological lens necessary to view chemicals in order to design safer substitutions. This book seeks to fill that gap and demonstrate how a basic understanding of toxicology, as well as the tools of in silico and in vitro toxicology, can be an integral part of green chemistry. R&D chemists, product stewards, and toxicologists who work in the field of sustainability, can all benefit from integrating green toxicology principles into their work. Topics include in silico tools for hazard assessment, toxicity testing, and lifecycle considerations, this book aims to act as a bridge between green toxicologists and green chemists.

Green Chemistry Strategies for Drug Discovery

Green Chemistry Strategies for Drug Discovery Book
Author : Emily A. Peterson,Julie B. Manley
Publisher : Royal Society of Chemistry
Release : 2015-06-11
ISBN : 1782622659
Language : En, Es, Fr & De

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Book Description :

The incorporation of Green Chemistry is a relatively new phenomenon in the drug discovery discipline, since the scale that chemists operate on in drug discovery is smaller than those of process and manufacturing chemistry. The necessary metrics are more difficult to obtain in drug discovery due to the diversity of reactions conducted. However, pharmaceutical companies are realizing that incorporation of green chemistry techniques at earlier stages of drug development can speed the development of a drug candidate. Written by experts who have pioneered green chemistry efforts within their own institutions, this book provides a practical guide for both academic and industrial labs wanting to know where to start with introducing greener approaches for greatest return on investment. The Editors have taken a comprehensive approach to the topic, covering the entire drug discovery process from molecule conception, through synthesis, formulation and toxicology with specific examples and case studies where green chemistry strategies have been implemented. Emerging techniques for performing greener drug discovery chemistry are addressed as well as cutting-edge topics like biologics discovery and continuous processing. Moreover, important surrounding issues such as intellectual property are included. This book serves as a practical guide for both academic and industrial chemists who work across the breadth of the drug discovery discipline. Ultimately, readers will learn how to incorporate green chemistry strategies into their everyday workflow without slowing down their science.

Sustainable Synthesis of Pharmaceuticals

Sustainable Synthesis of Pharmaceuticals Book
Author : Mariette M. Pereira,Mario J. F. Calvete
Publisher : Royal Society of Chemistry
Release : 2018-03-26
ISBN : 1788010655
Language : En, Es, Fr & De

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Book Description :

There is a growing interest in the development of sustainable processes for the synthesis of pharmaceuticals and this book bridges the divide between industrial examples and the fundamental chemistry. It explains the basic principles of using transition metal catalysis with several green approaches for the synthesis of pharmaceuticals. The topic is an important one for green chemistry and the chapters in this book on hydroformylation, green oxidation and olefin metathesis will also be of interest to both medicinal and organic chemists. Written by leading experts in the field, it provides a valuable and easy tool for scientists and industrialists who require information regarding this topic.

Green Sustainable Process for Chemical and Environmental Engineering and Science

Green Sustainable Process for Chemical and Environmental Engineering and Science Book
Author : Dr Inamuddin,Rajender Boddula,Mohammed Muzibur Rahman,Abdullah M. Asiri
Publisher : Elsevier
Release : 2021-03-18
ISBN : 0128225564
Language : En, Es, Fr & De

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Book Description :

Green Sustainable Process for Chemical and Environmental Engineering and Science: Solid State Synthetic Methods cover recent advances made in the field of solid-state materials synthesis and its various applications. The book provides a brief introduction to the topic and the fundamental principles governing the various methods. Sustainable techniques and green processes development in solid-state chemistry are also highlighted. This book also provides a comprehensive literature on the industrial application using solid-state materials and solid-state devices. Overall, this book is intended to explore green solid-state techniques, eco-friendly materials involved in organic synthesis and real-time applications. Provides a broad overview of solid-state chemistry Outlines an eco-friendly solid-state synthesis of modern nanomaterials, organometallic, coordination compounds and pure organic Gives a detailed account of solid-state chemistry, fundamentals, concepts, techniques and applications Deliberates cutting-edge recent advances in industrial technologies involved in energy, environmental, medicinal and organic chemistry fields

In Silico Methods for Drug Design and Discovery

In Silico Methods for Drug Design and Discovery Book
Author : Simone Brogi,Teodorico Castro Ramalho,José L. Medina-Franco,Kamil Kuca,Marian Valko
Publisher : Frontiers Media SA
Release : 2020-10-09
ISBN : 2889660575
Language : En, Es, Fr & De

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Book Description :

Download In Silico Methods for Drug Design and Discovery book written by Simone Brogi,Teodorico Castro Ramalho,José L. Medina-Franco,Kamil Kuca,Marian Valko, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Applications of Nanotechnology for Green Synthesis

Applications of Nanotechnology for Green Synthesis Book
Author : Inamuddin,Abdullah M. Asiri
Publisher : Springer Nature
Release : 2020-07-02
ISBN : 3030441768
Language : En, Es, Fr & De

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Book Description :

Traditional methods in synthetic chemistry produce chemical waste and byproducts, yield smaller desired products, and generate toxic chemical substances, but the past two centuries have seen consistent, greener improvements in organic synthesis and transformations. These improvements have contributed to substance handling efficiency by using green-engineered forerunners like sustainable techniques, green processes, eco-friendly catalysis, and have minimized energy consumption, reduced potential waste, improved desired product yields, and avoided toxic organic precursors or solvents in organic synthesis. Green synthesis has the potential to have a major ecological and monetary impact on modern pharmaceutical R&D and organic chemistry fields. This book presents a broad scope of green techniques for medicinal, analytical, environmental, and organic chemistry applications. It presents an accessible overview of new innovations in the field, dissecting the highlights and green chemistry attributes of approaches to green synthesis, and provides cases to exhibit applications to pharmaceutical and organic chemistry. Although daily chemical processes are a major part of the sustainable development of pharmaceuticals and industrial products, the resulting environmental pollution of these processes is of worldwide concern. This edition discusses green chemistry techniques and sustainable processes involved in synthetic organic chemistry, natural products, drug syntheses, as well various useful industrial applications.

Green and Sustainable Pharmacy

Green and Sustainable Pharmacy Book
Author : Klaus Kümmerer,Maximilian Hempel
Publisher : Springer Science & Business Media
Release : 2010-06-16
ISBN : 3642051995
Language : En, Es, Fr & De

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Book Description :

Within recent years pharmaceuticals have come into focus as contaminants of the environment (see for example Kümmerer, K. editor: Pharmaceuticals in the Environment). At the same time the issue of sustainable chemistry gained momentum. Bringing both together would result in sustainable pharmacy. Sustainable pharmacy is a totally new issue and approach. It addresses environmental, economical and social aspects of pharmacy. In the present stage the focus will be on environmental issues along the whole lifecycle of a pharmaceutical entity. That is dealing with resources and energy input but also with waste issues for example during the synthesis and production of an active pharmaceutical ingredient. Furthermore, it would also look on the compounds themselves and will aim to improve the degradability of the compounds after their use in the environment to reduce the environmental risk caused by pharmaceuticals in the environment. Another issue is the people using pharmaceuticals such as pharmacists, medical doctors and patients. How can they contribute to more efficient use of pharmaceuticals with less environmental burden and less risk for drinking water. The book "Sustainable Pharmacy" will address all these issues and will be the first one dealing with this important topic.

Microwave Heating as a Tool for Sustainable Chemistry

Microwave Heating as a Tool for Sustainable Chemistry Book
Author : Nicholas E. Leadbeater
Publisher : CRC Press
Release : 2010-09-02
ISBN : 9781439812709
Language : En, Es, Fr & De

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Book Description :

Shorter reaction times, higher product yields, and enhanced selectivity are some of the advantages microwave heating has over conventional methods, causing its use to transition from a curiosity to mainstream, both in industrial and academic settings. Microwave Heating as a Tool for Sustainable Chemistry showcases the application of microwave heati

Fragment Based Drug Discovery

Fragment Based Drug Discovery Book
Author : Edward R. Zartler,Michael Shapiro
Publisher : John Wiley & Sons
Release : 2008-11-20
ISBN : 0470721561
Language : En, Es, Fr & De

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Book Description :

Fragment-based drug discovery (FBDD) is a new paradigm in drug discovery that utilizes very small molecules - fragments of larger molecules. It is a faster, cheaper, smarter way to do drug discovery, as shown by the number of pharmaceutical companies that have embraced this approach and the biotechnology companies who use fragments as their sole source of drug discovery. Fragment-Based Drug Discovery: A Practical Approach is a guide to the techniques and practice of using fragments in drug screening. The emphasis is on practical guidance, with procedures, case studies, practical tips, and contributions from industry. Topics covered include: an introduction to fragment based drug discovery, why using fragments is a more efficient process than predominant models, and what it means to have a successful FBDD effort. setting up an FBDD project library building and production NMR in fragment screening and follow up application of protein-ligand NOE matching to the rapid evaluation of fragment binding poses target immobilized NMR screening: validation and extension to membrane proteins in situ fragment-based medicinal chemistry: screening by mass spectrometry computational approaches to fragment and substructure discovery and evaluation virtual fragment scanning: current trends, applications and web based tools fragment-based lead discovery using covalent capture methods case study from industry: the identification of high affinity beta-secretase inhibitors using fragment-based lead generation With contributions from industry experts who have successfully set up an industrial fragment-based research program, Fragment-Based Drug Discovery: A Practical Approach offers essential advice to anyone embarking on drug discovery using fragments and those looking for a new approach to screening for drugs.

Drug Selectivity

Drug Selectivity Book
Author : Norbert Handler,Helmut Buschmann,Raimund Mannhold,Jörg Holenz
Publisher : John Wiley & Sons
Release : 2018-02-05
ISBN : 3527335382
Language : En, Es, Fr & De

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Book Description :

The book provides a current overview and comprehensive compilation for medicinal chemists that discusses the effects of aiming for multiple targets on the entire drug development process. The result is a broad survey of current and future strategies for drug selectivity in medicinal chemistry with theoretical but also practical aspects. Different strategies are presented and evaluated, such as various design approaches, merged multiple ligands, discovery technologies and a broad range of successful examples of unselective drugs taken from all major disease areas. With its wide-ranging view of an emerging new paradigm in drug development, this handbook is of prime importance for every medicinal and pharmaceutical chemist.

Green Nanomaterials

Green Nanomaterials Book
Author : Kaushik Pal
Publisher : CRC Press
Release : 2022-02-17
ISBN : 1000291448
Language : En, Es, Fr & De

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Book Description :

Recent technological advancements in green nanotechnology have opened a brand-new avenue for research and development in the field of medicinal plant-mediated nanoparticles, biopolymers, biotechnology, and antimicrobial and biomedical research. This new volume explores several eco-friendly technologies in green materials synthesis, which are of considerable importance. It takes an inter- and cross-multidisciplinary approach to the green chemistry of nanoengineering and green nanotechnology application in materials research. It provides informative coverage of this exciting and dynamic new field as well as relates the fundamentals of soft-nanomaterials fabrication and spectroscopic integration. The book explores bio-inspired self-assembly green nanomaterials for multifunctional applications as well as the design and synthesis of green polymeric nanomaterials for several pharmaceutical and biomedical applications, including biosensors, drug delivery, antimicrobial applications, etc. Also discussed is the fabrication of green polymer nanocomposites from waste and natural fibers, such as chitin fiber, chitin whisker fiber, cellulose fiber, nanocellulose fiber, eggshells, and cotton waste.

New Trends in Green Chemistry

New Trends in Green Chemistry Book
Author : V.K. Ahluwalia,M. Kidwai
Publisher : Springer Science & Business Media
Release : 2012-12-06
ISBN : 1402031750
Language : En, Es, Fr & De

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Book Description :

Organic chemistry has played a vital role in the development of diverse molecules which are used in medicines, agrochemicals and polymers. Most ofthe chemicals are produced on an industrial scale. The industrial houses adopt a synthesis for a particular molecule which should be cost-effective. No attention is paid to avoid the release of harmful chemicals in the atmosphere, land and sea. During the past decade special emphasis has been made towards green synthesis which circumvents the above problems. Prof. V. K. Ahluwalia and Dr. M. Kidwai have made a sincere effort in this direction. This book discusses the basic principles of green chemistry incorporating the use of green reagents, green catalysts, phase transfer catalysis, green synthesis using microwaves, ultrasound and biocatalysis in detail. Special emphasis is given to liquid phase reactions and organic synthesis in the solid phase. I must congratulate both the authors for their pioneering efforts to write this book. Careful selection of various topics in the book will serve the rightful purpose for the chemistry community and the industrial houses at all levels. PROF. JAVED IQBAL, PhD, FNA Distinguished Research Scientist & Head Discovery Research Dr. Reddy's Laboratories Ltd.

Chemoinformatics for Drug Discovery

Chemoinformatics for Drug Discovery Book
Author : Jürgen Bajorath
Publisher : John Wiley & Sons
Release : 2013-09-25
ISBN : 1118743091
Language : En, Es, Fr & De

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Book Description :

Chemoinformatics strategies to improve drug discoveryresults With contributions from leading researchers in academia and thepharmaceutical industry as well as experts from the softwareindustry, this book explains how chemoinformatics enhances drugdiscovery and pharmaceutical research efforts, describing whatworks and what doesn't. Strong emphasis is put on tested and provenpractical applications, with plenty of case studies detailing thedevelopment and implementation of chemoinformatics methods tosupport successful drug discovery efforts. Many of these casestudies depict groundbreaking collaborations between academia andthe pharmaceutical industry. Chemoinformatics for Drug Discovery is logicallyorganized, offering readers a solid base in methods and models andadvancing to drug discovery applications and the design ofchemoinformatics infrastructures. The book features 15 chapters,including: What are our models really telling us? A practical tutorial onavoiding common mistakes when building predictive models Exploration of structure-activity relationships and transfer ofkey elements in lead optimization Collaborations between academia and pharma Applications of chemoinformatics in pharmaceuticalresearch—experiences at large international pharmaceuticalcompanies Lessons learned from 30 years of developing successfulintegrated chemoinformatic systems Throughout the book, the authors present chemoinformaticsstrategies and methods that have been proven to work inpharmaceutical research, offering insights culled from their owninvestigations. Each chapter is extensively referenced withcitations to original research reports and reviews. Integrating chemistry, computer science, and drug discovery,Chemoinformatics for Drug Discovery encapsulates the fieldas it stands today and opens the door to further advances.

Synthesis of Medicinal Agents from Plants

Synthesis of Medicinal Agents from Plants Book
Author : Ashish Tewari,Supriya Tiwari
Publisher : Elsevier
Release : 2018-04-17
ISBN : 0081022743
Language : En, Es, Fr & De

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Book Description :

Synthesis of Medicinal Agents from Plants highlights the importance of synthesizing medicinal agents from plants and outlines methods for performing it effectively. Beginning with an introduction to the significance of medicinal plants, the book goes on to provide a historical overview of drug synthesis before exploring how this can be used to successfully replicate and adapt the active agents from natural sources. Chapters then explore the medicinal properties of a number of important plants, before concluding with a discussion of the future of drugs from medicinal plants. Illustrated with real-world examples, it is a practical resource for researchers in this field. In an age of rapid environmental destruction, hundreds of medicinal plants are at risk of extinction from overexploitation and deforestation, limiting the natural resources available for active agent extraction, thereby threatening the discovery of future cures for diseases. Simultaneously, with the increasing population and advances in medical sciences, the demand for drugs is continuously increasing and cannot be met with just plants. The ability to synthetically replicate the active compounds from these plants is essential in creating an ecologically-aware, sustainable future for drug design Includes detailed coverage of therapeutic compound synthesis Uses multiple real-world examples to support content Lays out a sustainable template for the future of developing active agents from natural products