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Green Approaches In Medicinal Chemistry For Sustainable Drug Design

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Green Approaches in Medicinal Chemistry for Sustainable Drug Design

Green Approaches in Medicinal Chemistry for Sustainable Drug Design Book
Author : Bimal K. Banik
Publisher : Advances in Green Chemistry
Release : 2020-04
ISBN : 0128175923
Language : En, Es, Fr & De

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Book Description :

Extensive experimentation and high failure rates are a well-recognised downside to the drug discovery process, with the resultant high levels of inefficiency and waste producing a negative environmental impact. Sustainable and Green Approaches in Medicinal Chemistry reveals how medicinal and green chemistry can work together to directly address this issue. After providing essential context to the growth of green chemistry in relation to drug discovery in Part 1, the book goes on to identify a broad range of practical methods and synthesis techniques in Part 2. Part 3 reveals how medicinal chemistry techniques can be used to improve efficiency, mitigate failure and increase the environmental benignity of the entire drug discovery process, whilst Parts 4 and 5 discuss natural products and microwave-induced chemistry. Finally, the role of computers in drug discovery is explored in Part 6.

Green Approaches in Medicinal Chemistry for Sustainable Drug Design

Green Approaches in Medicinal Chemistry for Sustainable Drug Design Book
Author : Bimal K. Banik
Publisher : Elsevier
Release : 2020-03-27
ISBN : 0128175931
Language : En, Es, Fr & De

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Book Description :

Extensive experimentation and high failure rates are a well-recognised downside to the drug discovery process, with the resultant high levels of inefficiency and waste producing a negative environmental impact. Sustainable and Green Approaches in Medicinal Chemistry reveals how medicinal and green chemistry can work together to directly address this issue. After providing essential context to the growth of green chemistry in relation to drug discovery in Part 1, the book goes on to identify a broad range of practical methods and synthesis techniques in Part 2. Part 3 reveals how medicinal chemistry techniques can be used to improve efficiency, mitigate failure and increase the environmental benignity of the entire drug discovery process, whilst Parts 4 and 5 discuss natural products and microwave-induced chemistry. Finally, the role of computers in drug discovery is explored in Part 6. Identifies novel and cost effective green medicinal chemistry approaches for improved efficiency and sustainability Reflects on techniques for a broad range of compounds and materials Highlights sustainable and green chemistry pathways for molecular synthesis

Contemporary Chemical Approaches for Green and Sustainable Drugs

Contemporary Chemical Approaches for Green and Sustainable Drugs Book
Author : Marianna Torok
Publisher : Elsevier
Release : 2021-07-15
ISBN : 9780128222485
Language : En, Es, Fr & De

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Book Description :

The design, discovery, development and use of medicinal agents produces a whole range of environmental contaminants which have a damaging ecological impact. By acknowledging and addressing these issues, chemists can take preventative steps at multiple stages in the process, from using computational models and selecting green solvents, to designing for degradation and creating new remediation tools. Contemporary Chemical Approaches for Green and Sustainable Drugs provides readers with the knowledge they need to integrate such sustainable approaches into their work. After an introduction to the major focus areas in the field, the book includes four parts, each dealing with different aspects of green and sustainable drug development from design to disposal. These include computer-aided drug design, green resourcing of drugs and drug candidates, an overview of the health concerns of pharmaceutical pollution, and a survey of potential chemical methods for its reduction. Drawing together the knowledge of a global team of experts, Contemporary Chemical Approaches for Green and Sustainable Drugs provides an inclusive overview of the chemical tools and approaches available for minimizing the negative environmental impact of current and newly developed drugs, making it a useful guide for all academic and industrial researchers across green and sustainable chemistry, medicinal chemistry, environmental chemistry and pharmaceutical science. Provides an integrative overview of the environmental risks of drugs and drug by products to support chemists in pre-emptively addressing these issues Highlights the advantages of computer-aided drug design, green and sustainable sourcing, and novel methods for the production of safer, more effective drugs Presents individual chapters written by renowned experts with diverse backgrounds Reflects research in practise through selected case studies and extensive state-of-the-art reference sections to serve as a starting point in the design of any specialized environmentally-conscious medicinal chemistry project

Microwaves in Chemistry Applications

Microwaves in Chemistry Applications Book
Author : Aparna Das,Bimal K. Banik
Publisher : Elsevier
Release : 2021-05-21
ISBN : 0128230851
Language : En, Es, Fr & De

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Book Description :

Microwaves in Chemistry Applications: Fundamentals, Methods and Future Trends offers a number of benefits over conventional heating technologies, including acceleration of reaction rates, milder reaction conditions, higher chemical yields, lower energy usage and different reaction selectivity, all of which can improve the sustainability of processes. The book provides valuable insights into the underlying chemistry at play in microwave-assisted processes, introducing fundamental concepts, discussing the modeling of reactions in such processes, and also highlighting a range of key methods and applications of microwaves in chemistry for improved sustainability. Beginning with an introduction to microwave chemistry, Part One discusses foundational principles, equipment and approaches for modeling reactions and assessing the outputs of those models. Methods in microwave chemistry are then the focus of Part Two, with microwave-assisted synthesis, catalysis, reduction and reactions all explored in detail. Part Three reflects on the practical usage of these methods to address specific issues, covering a number of interesting applications. Provides guidance on the modeling and interpretation of microwave effects Discusses microwave chemistry in the context of green chemistry principles Outlines a range of important microwave methods, including microwave-assisted synthesis, catalysis, reactions and reductions

Green Chemistry Strategies for Drug Discovery

Green Chemistry Strategies for Drug Discovery Book
Author : Emily A. Peterson,Julie B. Manley
Publisher : Royal Society of Chemistry
Release : 2015-06-11
ISBN : 1782622659
Language : En, Es, Fr & De

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Book Description :

The incorporation of Green Chemistry is a relatively new phenomenon in the drug discovery discipline, since the scale that chemists operate on in drug discovery is smaller than those of process and manufacturing chemistry. The necessary metrics are more difficult to obtain in drug discovery due to the diversity of reactions conducted. However, pharmaceutical companies are realizing that incorporation of green chemistry techniques at earlier stages of drug development can speed the development of a drug candidate. Written by experts who have pioneered green chemistry efforts within their own institutions, this book provides a practical guide for both academic and industrial labs wanting to know where to start with introducing greener approaches for greatest return on investment. The Editors have taken a comprehensive approach to the topic, covering the entire drug discovery process from molecule conception, through synthesis, formulation and toxicology with specific examples and case studies where green chemistry strategies have been implemented. Emerging techniques for performing greener drug discovery chemistry are addressed as well as cutting-edge topics like biologics discovery and continuous processing. Moreover, important surrounding issues such as intellectual property are included. This book serves as a practical guide for both academic and industrial chemists who work across the breadth of the drug discovery discipline. Ultimately, readers will learn how to incorporate green chemistry strategies into their everyday workflow without slowing down their science.

Green Techniques for Organic Synthesis and Medicinal Chemistry

Green Techniques for Organic Synthesis and Medicinal Chemistry Book
Author : Wei Zhang,Berkeley W. Cue
Publisher : John Wiley & Sons
Release : 2012-05-10
ISBN : 1118308654
Language : En, Es, Fr & De

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Book Description :

An updated overview of the rapidly developing field of green engineering techniques for organic synthesis and medicinal chemistry Green chemistry remains a high priority in modern organic synthesis and pharmaceutical R&D, with important environmental and economic implications. This book presents comprehensive coverage of green chemistry techniques for organic and medicinal chemistry applications, summarizing the available new technologies, analyzing each technique’s features and green chemistry characteristics, and providing examples to demonstrate applications for green organic synthesis and medicinal chemistry. The extensively revised edition of Green Techniques for Organic Synthesis and Medicinal Chemistry includes 7 entirely new chapters on topics including green chemistry and innovation, green chemistry metrics, green chemistry and biological drugs, and the business case for green chemistry in the generic pharmaceutical industry. It is divided into 4 parts. The first part introduces readers to the concepts of green chemistry and green engineering, global environmental regulations, green analytical chemistry, green solvents, and green chemistry metrics. The other three sections cover green catalysis, green synthetic techniques, and green techniques and strategies in the pharmaceutical industry. Includes more than 30% new and updated material—plus seven brand new chapters Edited by highly regarded experts in the field (Berkeley Cue is one of the fathers of Green Chemistry in Pharma) with backgrounds in academia and industry Brings together a team of international authors from academia, industry, government agencies, and consultancies (including John Warner, one of the founders of the field of Green Chemistry) Green Techniques for Organic Synthesis and Medicinal Chemistry, Second Edition is an essential resource on green chemistry technologies for academic researchers, R&D professionals, and students working in organic chemistry and medicinal chemistry.

Hazardous Reagent Substitution

Hazardous Reagent Substitution Book
Author : Rakeshwar Bandichhor,Rakesh Kumar Sharma
Publisher : Royal Society of Chemistry
Release : 2017-11-28
ISBN : 178801376X
Language : En, Es, Fr & De

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Book Description :

In recent years, a significant amount of progress has been made using green chemistry in the synthesis of synthetically useful compounds and molecules by replacing hazardous chemicals with greener alternatives. However, there is still room for improvement, especially in the pharmaceutical sector where new drugs are being formulated. This book examines green approaches to overcoming hazardous organic transformations. Summarizing recent developments, the book features a detailed description of some of the high impact active pharmaceutical ingredients that have been developed considering green chemistry approaches. It explores the design, engineering and process development and the calculations to account for waste. The book includes strategies to further advance green approaches in the development of generic pharmaceutical industries and features novel, innovative approaches that promote waste-free organic synthesis. This book is of interest to industrialists working in pharmaceuticals and researchers working in green chemistry.

Green Sustainable Process for Chemical and Environmental Engineering and Science

Green Sustainable Process for Chemical and Environmental Engineering and Science Book
Author : Dr. Inamuddin,Rajender Boddula,Mohd Imran Ahamed,Abdullah M. Asiri
Publisher : Elsevier
Release : 2020-12-04
ISBN : 0128218851
Language : En, Es, Fr & De

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Book Description :

Green Sustainable Process for Chemical and Environmental Engineering and Science: Solvents for the Pharmaceutical Industry aims at providing a detailed overview of applications of green solvents in pharmaceutical industries. It also focuses on providing a detailed literature survey on the green solvents for pharmaceutical analysis, drug design, synthesis, and production, etc. It summarizes the applications of various greens solvents such as water, cyrene, vegetable oils, ionic liquids, ethyl lactate, eutectic solvents, and glycerol in contrast to toxic solvents. This book provides an overview of the use of green solvents for the sustainable and environmentally friendly development of synthetic methodologies for biomedical and pharmaceutical industries. Up-to-date developments towards the development of solvents for pharmaceutical industry Includes latest advances in pharmaceutical analysis and synthesis using green solvents Outlines eco-friendly green solvents for medicinal applications State-of-the-art overview on the exploration of green solvents for pharmaceutical industries

Microwave Heating as a Tool for Sustainable Chemistry

Microwave Heating as a Tool for Sustainable Chemistry Book
Author : Nicholas E. Leadbeater
Publisher : CRC Press
Release : 2010-09-02
ISBN : 9781439812709
Language : En, Es, Fr & De

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Book Description :

Shorter reaction times, higher product yields, and enhanced selectivity are some of the advantages microwave heating has over conventional methods, causing its use to transition from a curiosity to mainstream, both in industrial and academic settings. Microwave Heating as a Tool for Sustainable Chemistry showcases the application of microwave heati

Chimie Pure Et Appliqu e

Chimie Pure Et Appliqu  e Book
Author : Anonim
Publisher : Unknown
Release : 2012
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Chimie Pure Et Appliqu e book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Green and Sustainable Pharmacy

Green and Sustainable Pharmacy Book
Author : Klaus Kümmerer,Maximilian Hempel
Publisher : Springer Science & Business Media
Release : 2010-06-16
ISBN : 3642051995
Language : En, Es, Fr & De

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Book Description :

Within recent years pharmaceuticals have come into focus as contaminants of the environment (see for example Kümmerer, K. editor: Pharmaceuticals in the Environment). At the same time the issue of sustainable chemistry gained momentum. Bringing both together would result in sustainable pharmacy. Sustainable pharmacy is a totally new issue and approach. It addresses environmental, economical and social aspects of pharmacy. In the present stage the focus will be on environmental issues along the whole lifecycle of a pharmaceutical entity. That is dealing with resources and energy input but also with waste issues for example during the synthesis and production of an active pharmaceutical ingredient. Furthermore, it would also look on the compounds themselves and will aim to improve the degradability of the compounds after their use in the environment to reduce the environmental risk caused by pharmaceuticals in the environment. Another issue is the people using pharmaceuticals such as pharmacists, medical doctors and patients. How can they contribute to more efficient use of pharmaceuticals with less environmental burden and less risk for drinking water. The book "Sustainable Pharmacy" will address all these issues and will be the first one dealing with this important topic.

Sustainable Flow Chemistry

Sustainable Flow Chemistry Book
Author : Luigi Vaccaro
Publisher : John Wiley & Sons
Release : 2016-12-12
ISBN : 3527689109
Language : En, Es, Fr & De

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Book Description :

This ready reference not only presents the hot and emerging topic of modern flow chemistry, it is also unique in illustrating the important connection to sustainable chemistry. Focusing on more sustainable methods and applications, the text extensively covers every important field from reaction time optimization to waste minimization, and from safety improvements to microwave applications. In addition, green metrics are presented as a key aspect of the book, helping readers to evaluate the efficiency of flow technologies and their impact on the overall efficiency of a chemical process. An invaluable handbook for every chemist working in the laboratory, whether in academia or industry.

Green Sustainable Process for Chemical and Environmental Engineering and Science

Green Sustainable Process for Chemical and Environmental Engineering and Science Book
Author : Dr. Inamuddin,Rajender Boddula,Abdullah M. Asiri
Publisher : Elsevier
Release : 2020-09-20
ISBN : 0128226706
Language : En, Es, Fr & De

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Book Description :

Microwaves in Organic Synthesis provides an in-depth overview in the area of organic and pharmaceutical chemistry of the microwave technology in separation, purification and extraction of medicinal, biological, and organic compounds.This book methodically explores the application of microwaves in all types of organic synthesis. It includes stereoselectivity, regioselectivity, oxidation, reduction, protection, deprotection, addition, condensation, coupling, C-X bond formation, named reactions, heterocyclic, biological drugs, fluoro-organics and polymers. After a brief introduction discusses the main parameters which influence the process, and the limitations and advantages of the practical use of microwave in organic synthesis. This book is a vital resource on green chemistry technologies for students and academic researchers, R& D professionals, students and university professors working in the field of organic chemistry, medicinal chemistry and chemical engineering. Outlines microwave technology for green organic synthesis Includes a description of the significant factors and challenges of the microwave-assisted green organic synthesis Outlines the eco-friendly microwave based chemical processes and their applications in organic reactions, polymer synthesis, biofuel production, etc. Gives detail account of the numerous real industrial applications such as polymers, pharmaceutical, fluoroorganics, biofuel, carbon, etc. Discusses recent advances in microwave technology in organic chemistry

Applications of Nanotechnology for Green Synthesis

Applications of Nanotechnology for Green Synthesis Book
Author : Inamuddin,Abdullah M. Asiri
Publisher : Springer
Release : 2020-07-28
ISBN : 9783030441753
Language : En, Es, Fr & De

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Book Description :

Traditional methods in synthetic chemistry produce chemical waste and byproducts, yield smaller desired products, and generate toxic chemical substances, but the past two centuries have seen consistent, greener improvements in organic synthesis and transformations. These improvements have contributed to substance handling efficiency by using green-engineered forerunners like sustainable techniques, green processes, eco-friendly catalysis, and have minimized energy consumption, reduced potential waste, improved desired product yields, and avoided toxic organic precursors or solvents in organic synthesis. Green synthesis has the potential to have a major ecological and monetary impact on modern pharmaceutical R&D and organic chemistry fields. This book presents a broad scope of green techniques for medicinal, analytical, environmental, and organic chemistry applications. It presents an accessible overview of new innovations in the field, dissecting the highlights and green chemistry attributes of approaches to green synthesis, and provides cases to exhibit applications to pharmaceutical and organic chemistry. Although daily chemical processes are a major part of the sustainable development of pharmaceuticals and industrial products, the resulting environmental pollution of these processes is of worldwide concern. This edition discusses green chemistry techniques and sustainable processes involved in synthetic organic chemistry, natural products, drug syntheses, as well various useful industrial applications.

Integrating Green Chemistry and Sustainable Engineering

Integrating Green Chemistry and Sustainable Engineering Book
Author : Shahid Ul-Islam
Publisher : John Wiley & Sons
Release : 2019-04-01
ISBN : 1119509823
Language : En, Es, Fr & De

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Book Description :

Over the past decade, the population explosion, rise in global warming, depletion of fossil fuel resources and environmental pollution has been the major driving force for promoting and implementing the principles of green chemistry and sustainable engineering in all sectors ranging from chemical to environmental sciences. It is noteworthy to mention that production of biofuels, exploitation of renewable energy sources and use of ecologically safer products in applied sectors are becoming increasingly important for the development of alternative sustainable technologies. Integrating Green Chemistry and Sustainable Engineering focusses on latest sustainable technologies and developments and describes how sustainable chemistry and engineering practices are being applied and integrated in various industrial sectors. The book addresses emerging topics including biofuel production, CO2 conversation to green fuels, advanced green polymers in coating applications, biological macromolecules in medical sector, biofertilizers for agricultural sector, bioadsorption and much more.

Applications of Nanotechnology for Green Synthesis

Applications of Nanotechnology for Green Synthesis Book
Author : Inamuddin,Abdullah M. Asiri
Publisher : Springer Nature
Release : 2020-07-02
ISBN : 3030441768
Language : En, Es, Fr & De

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Book Description :

Traditional methods in synthetic chemistry produce chemical waste and byproducts, yield smaller desired products, and generate toxic chemical substances, but the past two centuries have seen consistent, greener improvements in organic synthesis and transformations. These improvements have contributed to substance handling efficiency by using green-engineered forerunners like sustainable techniques, green processes, eco-friendly catalysis, and have minimized energy consumption, reduced potential waste, improved desired product yields, and avoided toxic organic precursors or solvents in organic synthesis. Green synthesis has the potential to have a major ecological and monetary impact on modern pharmaceutical R&D and organic chemistry fields. This book presents a broad scope of green techniques for medicinal, analytical, environmental, and organic chemistry applications. It presents an accessible overview of new innovations in the field, dissecting the highlights and green chemistry attributes of approaches to green synthesis, and provides cases to exhibit applications to pharmaceutical and organic chemistry. Although daily chemical processes are a major part of the sustainable development of pharmaceuticals and industrial products, the resulting environmental pollution of these processes is of worldwide concern. This edition discusses green chemistry techniques and sustainable processes involved in synthetic organic chemistry, natural products, drug syntheses, as well various useful industrial applications.

Biocatalysis for Green Chemistry and Chemical Process Development

Biocatalysis for Green Chemistry and Chemical Process Development Book
Author : Junhua (Alex) Tao,Romas Joseph Kazlauskas
Publisher : John Wiley & Sons
Release : 2011-06-09
ISBN : 9781118028292
Language : En, Es, Fr & De

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Book Description :

This book describes recent progress in enzyme-driven green syntheses of industrially important molecules. The first three introductory chapters overview recent technological advances in enzymes and cell-based transformations, and green chemistry metrics for synthetic efficiency. The remaining chapters are directed to case studies in biotechnological production of pharmaceuticals (small molecules, natural products and biologics), flavors, fragrance and cosmetics, fine chemicals, value-added chemicals from glucose and biomass, and polymeric materials. The book is aimed to facilitate the industrial applications of this powerful and emerging green technology, and catalyze the advancement of the technology itself.

Green Sustainable Process for Chemical and Environmental Engineering and Science

Green Sustainable Process for Chemical and Environmental Engineering and Science Book
Author : Dr. Inamuddin,Rajender Boddula,Abdullah M. Asiri
Publisher : Elsevier
Release : 2020-07-10
ISBN : 0128195401
Language : En, Es, Fr & De

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Book Description :

Green Sustainable Process for Chemical and Environmental Engineering and Science: Sonochemical Organic Synthesis focuses on purification and extraction of organic, biological, and medicinal compounds using sonochemistry. It provides readers with an understanding of green ultrasound-assisted chemical synthesis for industrial applications. This book systematically explores the application of ultrasound in organic synthesis of all types and includes stereoselectivity, regioselectivity, oxidations, reductions, protection, deprotection, additions, condensation, coupling, C-X bond formation, named reactions, heterocyclics, biological drugs, and fluoroorganics over conventional techniques. A brief introduction to the parameters which influence the process, solvent-effects, supported reagents and catalysis and the pros and cons to the practical use of sonochemical protocols in organic synthesis are also discussed. This book provides overview on the applications of sonochemical technology for the sustainable and environmentally friendly development of synthetic methodologies for organic and pharmaceutical chemistry. Sonochemical Organic Synthesis is an essential resource on green chemistry technologies for academic researchers, R&D professionals, and students working in modern organic chemistry and medicinal chemistry. Offers a broad overview of ultrasonics-assisted green organic synthesis Discusses sonochemical technology for green organic synthesis and biological medicinal importance Gives detailed accounts of numerous industrial applications, including polymers, pharmaceutical, fluoroorganics, biofuel, carbon, and more Includes a description of significant factors and challenges in ultrasonics-assisted green organic synthesis Lists recent developments in the use of sonochemical technology in organic chemist

Sustainable Synthesis of Pharmaceuticals

Sustainable Synthesis of Pharmaceuticals Book
Author : Mariette M Pereira,Mário J F Calvete
Publisher : Royal Society of Chemistry
Release : 2018-03-26
ISBN : 1788014413
Language : En, Es, Fr & De

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Book Description :

There is a growing interest in the development of sustainable processes for the synthesis of pharmaceuticals and this book bridges the divide between industrial examples and the fundamental chemistry. It explains the basic principles of using transition metal catalysis with several green approaches for the synthesis of pharmaceuticals. The topic is an important one for green chemistry and the chapters in this book on hydroformylation, green oxidation and olefin metathesis will also be of interest to both medicinal and organic chemists. Written by leading experts in the field, it provides a valuable and easy tool for scientists and industrialists who require information regarding this topic.

Green Chemistry for Environmental Remediation

Green Chemistry for Environmental Remediation Book
Author : Rashmi Sanghi,Vandana Singh
Publisher : John Wiley & Sons
Release : 2012-01-20
ISBN : 111828772X
Language : En, Es, Fr & De

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Book Description :

The book presents an in depth review from eminent industry practitioners and researchers of the emerging green face of multidimensional environmental chemistry. Topics such as green chemistry in industry, green energy: solar photons to fuels, green nanotechnology and sustainability, and green chemistry modeling address a wide array of iusses encouraging the use of economical ecofriendly benign technologies, which not only improve the yield, but also illustrates the concept of zero waste, a subject of interest to both chemists and environmentalists alike.