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Novel Therapeutic Advances in Glioblastoma

Novel Therapeutic Advances in Glioblastoma Book
Author : Anonim
Publisher : Academic Press
Release : 2020-05-22
ISBN : 0128211156
Language : En, Es, Fr & De

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Book Description :

Novel Therapeutic Advances in Glioblastoma, Volume 151 in the International Review of Neurobiology series, highlights new advances in the field, with this new volume presenting interesting chapters on a variety of topics, including Blood-brain barrier and pathophysiology of brain tumors, Promising strategies of glioblastoma treatment: personalized genotoxic therapy and stem cell transplantation, Extracellular matrix and biocompatible materials in glioblastoma treatment, Expression of Twist associated to microcirculation patterns of human glioma correlated with progression and survival of the patient, Advanced Multimodal Imaging in Differentiating Glioma Recurrence from Post-radiotherapy Changes, Advanced Multimodal Imaging in Differentiating Glioma Recurrence from Post-radiotherapy Changes, and much more. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the International Review of Neurobiology series Updated release includes the latest information on glioblastomas

Glioblastoma

Glioblastoma  Book
Author : Swapan K. Ray
Publisher : Springer Science & Business Media
Release : 2009-10-31
ISBN : 9781441904102
Language : En, Es, Fr & De

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Book Description :

Glioblastoma is the most malignant brain tumor that still remains incurable. It is such a deadly disease that patients do not survive more than a few months after diagnosis. Our understanding of the histopathology and molecular mechanisms of formation of glioblastoma is rapidly advancing so as to provide us clues for devising rational therapeutic strategies for treatment of this malignancy. It is important that we continue to improve our knowledge about the pathogenesis of this devastating disease and explore new areas to find successful therapeutic strategies. Various approaches such as sophisticated imaging techniques, improved surgical procedures, ground-breaking strategies for radiotherapy, chemotherapy, immunotherapy, chemoimmunotherapy, and photodynamic therapy are being used for eradicating glioblastoma. Hopefully, this book will be an important source of information on glioblastoma and therefore be highly useful to the students, postdoctoral fellows, principal investigators, and clinicians involved in this field.

Glioblastoma Multiforme

Glioblastoma Multiforme Book
Author : Steven A. Rosenberg,Vincent T. DeVita, Jr.
Publisher : Jones & Bartlett Learning
Release : 2005
ISBN : 9780763726409
Language : En, Es, Fr & De

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Book Description :

Treatment of malignant glioma remains a major challenge for neurosurgeons, neurologists, medical oncologists, and radiation oncologists caring for patients with these tumors. Glioblastoma multiforme, the most common type of brain tumor, is also the most deadly -- only five percent of patients or fewer will be alive at five years after diagnosis. This comprehensive new reference is edited by a renowned team consisting of a neurosurgeon, medical oncologist, oncologic surgeon, and radiation oncologist. The book provides basic researchers and clinicians with a contemporary review of the epidemiology, diagnosis, and treatment of glioblastoma multiforme, and also imparts to experienced investigators outside of the field sufficient background to apply their skills to the treatment of this deadly disease. Expert malignant glioma researchers and clinicians provide state-of-the-art chapters on important topics such as molecular genetic classification of glioblastoma, surgical management, stem cell therapy, chemotherapy, angiogenesis, and more.

A Statistic of One

A Statistic of One Book
Author : Stephen Hatrak
Publisher : iUniverse
Release : 2012-05
ISBN : 1475916345
Language : En, Es, Fr & De

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Book Description :

"A Statistic of One: My Walk with Glioblastoma Multiforme" traces Stephen Hatrak's life from his diagnosis of glioblastoma multiforme, the deadliest of malignant brain tumors, to the present. He chronicles the trials and tribulations he faced and the losses he suffered along his journey. Faith and inner strength are formidable allies in overcoming any tragedy in one's life, and they played vital roles in his struggle. He was told from the start that the he might have twelve months to live; even so, he defi ed the odds and, six years later, is telling his own story. Despite the dire statistics associated with a diagnosis of glioblastoma, there are several stories of long-term survival; these stories gave him hope that this cancer could be tamed. To overcome this challenge in his life, he had to believe in himself and fi nd his inner sixth sense to strengthen his resolve. Along the way, he learned that life with brain cancer could be tough, but that he could be even tougher. What cancer cannot do....separate me from my soul, squash my spirit, and stop the sun from rising in the east and setting in the west; creating new tomorrows and new opportunities. "A Statistic of One" is an uplifting story of faith and perseverance; how we cope with challenge will determine how we move forward and live life to its fullest.

Glioblastoma E Book

Glioblastoma E Book Book
Author : Steven Brem,Kalil G. Abdullah
Publisher : Elsevier Health Sciences
Release : 2016-09-22
ISBN : 032347974X
Language : En, Es, Fr & De

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Book Description :

Clinically focused and designed to provide a to-the-point overview, Glioblastoma , by Drs. Steven Brem and Kalil G. Abdullah, brings you up to date with increased understanding, new treatment protocols, and recent advances in the field. Written by contributing specialists who are global experts in their respective areas, this one-stop reference provides neurosurgeons, medical-and-radiation oncologists, neuro-oncologists, neuropathologists, internal medicine physicians, and researchers with a dependable source of information on current treatment options, tumor recurrence, and patient care. Evidence for current treatment options for de novo and recurrent glioblastoma, indications for local and topical therapies, immunotherapy, gene therapy, nanotherapy, small-molecule inhibition, electric tumor treating field stimulation, and antiangiogenic therapies and the role of Avastin. Recent advances relating to tumor resection, such as stereotactic laser ablation, diffusion tensor imaging, and fluorescent markers. Prognostic molecular and genetic markers and the impact of gene mutations on survival, as well as controversies relating to pseudo-progression. Lessons learned from unsuccessful interventions, as well as the most promising aspects of future glioblastoma research and treatment.

Radiobiology of Glioblastoma

Radiobiology of Glioblastoma Book
Author : Luigi Pirtoli,Giovanni Luca Gravina,Antonio Giordano
Publisher : Springer
Release : 2016-06-06
ISBN : 3319283057
Language : En, Es, Fr & De

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Book Description :

This text properly considers the most recent and relevant advances in molecular RB of GB, taking into account the related topics of pathobiology, and underscores the most promising translational perspectives from the preclinical to the clinical domain. Section I (From Bedside to Bench) discusses conditions associated with RT resistance of GB and the consequent RB hints, technology improvements intended to overcome RT-resistance of GB, mathematical modeling of RB parameters from clinical studies, the present impact of molecular prognostic factors in therapy of GB, and RT tolerance of normal brain. Section II (Preclinical Research and Pathobiology Topics) presents the traditional and mechanistic/molecular approaches to RB of GB, genetic and epigenetic studies on GB, issues of cell-death pathways, stem-like cells, invasiveness, tumor microenvironment, hypoxia, mi-RNA manipulations, and nanoparticle technology. Section III (Translational Perspectives) presents RB issues related to molecular profiling and classification of GB as frames of reference for clinical studies, translational perspectives of gene therapy, evolving protocols based on pre-clinical data and large data-bases and ontologic models. Radiobiology of Glioblastoma: Recent Advances and Related Pathobiology will be of great value to pathologists, medical oncologists, radiation oncologists as well as basic researchers and clinical investigators.

Precision Molecular Pathology of Glioblastoma

Precision Molecular Pathology of Glioblastoma Book
Author : José Javier Otero,Aline Paixao Becker
Publisher : Springer
Release : 2021-05-19
ISBN : 9783030691691
Language : En, Es, Fr & De

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Book Description :

This volume provides a balanced and realistic review of the current state of glioblastoma, ranging from traditional histological review, molecular pathology of glioma, modern radiomics, neurosurgical focus, and integration of treatment plans by neuro-oncologists. The book reviews basic principles such as epidemiology and etiology, and modern 2016 WHO classification of CNS tumors. Chapters cover a general overview of common molecular techniques used in molecular pathology, molecular pathology in a developing country, key drivers of patient outcomes and predictors of response to radiation and/or chemotherapy treatment, and immunohistochemical surrogates for key molecular pathology. It concludes with reviews on radiomics, animal and stem cell models of glioblastoma, and a chapter on the emerging field of Glioblastoma Neuroscience. Precision Molecular Pathology of Glioblastoma is intended for pathology residents and fellows interested in glioblastoma, general surgical pathologists who need reviews on how to implement modern glioblastoma classification, as well as neuro-radiologists, oncologists, and radiation oncologists needing a holistic perspective to glioblastoma diagnosis and management.

Glioblastoma

Glioblastoma Book
Author : Marcelo F. Bezerra,Claudio R. Alves
Publisher : Nova Biomedical
Release : 2012
ISBN : 9781621008583
Language : En, Es, Fr & De

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Book Description :

Glioblastoma is the most common and lethal primary brain tumor which exhibits clinical, radiological and pathological heterogenity. Despite advances in standard therapy, including surgical resection, radiotherapy and chemotherapy, the prognosis for patients remains poor. In this book, the authors present topical research on the risk factors, diagnosis and treatment options for glioblastoma. Topics discussed include the therapeutic potential of scorpion toxins against glioblastoma; co-amplified oncogenes in glioblastoma; mesenchymal stem cells as a novel therapeutic delivery vehicle for glioblastoma; targeting fibroblast growth factor (FGF) signals and how to stop glial neoplastic brain development. (Imprint: Nova Biomedical)

Tumors of the Central Nervous System Volume 1

Tumors of the Central Nervous System  Volume 1 Book
Author : M. A. Hayat
Publisher : Springer Science & Business Media
Release : 2011-03-23
ISBN : 9789400703445
Language : En, Es, Fr & De

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Book Description :

The most recent developments in diagnostic and therapeutic aspects of Gliomas (Glioblastoma) in the brain are presented. The importance of personalized medicine and clinical validation for targeted therapy are discussed. The identification of various types of biomarkers is included. The identification and validation of brain cancer (glioblastoma) genes are discussed. Role of cancer stem cells in the initiation, progression, and persistence of malignant gliomas is explained. The use of surgical resection, chemotherapy (e.g., temozolomide), immunotherapy, and radiotherapy for malignant glioblastoma are pointed out. Standard (established) as well as newer imaging modalities (proton magnetic resonance spectroscopy) are discussed.

Tumors of the Central Nervous System Volume 2

Tumors of the Central Nervous System  Volume 2 Book
Author : M.A. Hayat
Publisher : Springer Science & Business Media
Release : 2011-04-03
ISBN : 9789400706187
Language : En, Es, Fr & De

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Book Description :

Advantages and limitations of biomarkers in gliomagenesis are described. Molecular subtypes of gliomas are detailed. The role played by TP53 gene mutation in the deadliest brain tumor, glioblastoma multiforme, is pointed out. The role of mutations of IDH1 and IDH2, and isocitrate dehydrogenases in malignant gliomas are presented. Metabolic differences in different regions of the glioma tumor are clarified. Various types of imaging modalities, including PET and SPECT, to diagnose gliomas in general and glioblastoma in particular in patients are explained in detail. Both low-grade and high-grade gliomas are discussed. Conventional as well as fluorescent-guided resection techniques for high-grade, recurrent malignant gliomas are detailed. Impact of resection extent on outcomes in patients with high-grade gliomas is clarified. The advantage of the use of intraoperative low-field MRI in glioma surgery is explained.

Glioblastoma Part II Molecular Targets and Clinical Trials An Issue of Neurosurgery Clinics of North America E Book

Glioblastoma  Part II  Molecular Targets and Clinical Trials  An Issue of Neurosurgery Clinics of North America  E Book Book
Author : Linda M. Liau
Publisher : Elsevier Health Sciences
Release : 2021-04-08
ISBN : 0323813062
Language : En, Es, Fr & De

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Book Description :

This issue of Neurosurgery Clinics, guest edited by Dr. Linda M. Liau, is dedicated to Glioblastoma: Molecular and Clinical Trials. This issue is one of four selected each year by the series consulting editors, Drs. Russell R. Lonser and Daniel K. Resnick. Topics will include—but are not limited to—Pathology & Molecular Markers, Cellular States & Genetic Diversity in Glioblastoma, Mismatch Repair in Glioblastoma Resistance, Genetic Susceptibility in Brain Cancer, Pediatric Gliomas: Molecular Landscape & Emerging Targets, Molecularly Targeted Clinical Trials, Novel Radiation Sensitizers, Immunotherapy Checkpoint Inhibitors, Brain Tumor Vaccines, CAR T Cells, Oncolytic Virotherapy, Targeting Cancer Stem Cells, Therapeutic Delivery to CNS, Theranostics: Dual Modality PET Tracers, and Neuroimaging & Novel Response Assessments.

Fast Facts Glioblastoma

Fast Facts  Glioblastoma Book
Author : M. McNamara,S. Brandner,S.C. Thust
Publisher : Karger Medical and Scientific Publishers
Release : 2020-02-26
ISBN : 1912776715
Language : En, Es, Fr & De

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Book Description :

Glioblastoma (also known as glioblastoma multiforme) is a malignant intrinsic tumor thought to arise from populations of stem/progenitor cells in the brain. It is the most common aggressive intrinsic brain tumor in adults, with the potential to spread rapidly within the brain. Patients with glioblastoma face a poor prognosis, with median overall survival of approximately 15 months. However, our growing understanding of the molecular biology of gliomas means that this outlook may be improving. The identification of clinically relevant subgroups defined by specific genetic mutations is challenging the traditional delineation between low- and high-grade gliomas that has been based on histological appearance and imaging. Indeed, it is becoming clear that, as a molecular entity, a glioblastoma, which by traditional classification is a grade IV glioma, may present with a lower grade initially and then become more aggressive – an important addition to the established concept. The care of a patient with a glioblastoma requires a coordinated approach delivered by a multidisciplinary team, with the aim of maintaining quality of life for as long as possible. Here, we provide a concise overview of the diagnosis and management of glioblastoma, as well as discussion of our emerging understanding of the molecular drivers that are helping us to delineate different patient subgroups. These subgroups will, hopefully, allow more targeted treatments in the future. This resource will be of interest to all those involved in caring for patients with this aggressive brain tumor, including neurologists, neurosurgeons, neuro-oncologists, radiation oncologists, palliative care specialists, specialist nurses and medical students. Contents: • Epidemiology, pathophysiology and classification • Clinical presentation • Diagnosis • Management • Treatment of associated conditions • Emerging research and treatment

Glioblastoma Resistance to Chemotherapy Molecular Mechanisms and Innovative Reversal Strategies

Glioblastoma Resistance to Chemotherapy  Molecular Mechanisms and Innovative Reversal Strategies Book
Author : Ramasamy Paulmurugan,Tarik F. Massoud, MD, PhD
Publisher : Elsevier
Release : 2021-07-02
ISBN : 0128215674
Language : En, Es, Fr & De

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Book Description :

Glioblastoma Resistance to Chemotherapy: Molecular Mechanisms and Innovative Reversal Strategies brings current knowledge from an international team of experts on the science and clinical management of glioblastoma chemoresistance. The book discusses topics such as molecular mechanisms of chemoresistance, experimental models to study chemoresistance, chemoresistance to drugs other than Temozolomide, and specific strategies to reverse chemoresistance. Additionally, it encompasses information on how to mitigate chemoresistance by targeted enhancement of p53 function. This book is a valuable resource for cancer researchers, oncologists, neuro-oncologists and other members of the biomedical field. Glioblastoma (GBM) is the most invasive and malignant primary brain tumor in humans with poor survival after diagnosis, therefore it is imperative that molecular and cellular mechanisms behind therapy resistant GBM cells, as well as the therapeutic strategies available to counter the resistance are comprehensively understood. Provides comprehensive, core knowledge related to the entire discipline of glioblastoma chemoresistance, from its many etiological mechanisms, to specific strategies to reverse resistance Presents current information from an international team of experts on the basic science, pre-clinical research, and clinical management of glioblastoma chemoresistance Discusses molecular and cellular mechanisms behind therapy resistant glioblastoma cells, as well as the therapeutic strategies available to counter this resistance

Targeted Therapies for Glioblastoma A Critical Appraisal

Targeted Therapies for Glioblastoma  A Critical Appraisal Book
Author : Shiv K. Gupta,Sani H. Kizilbash,Thierry M. Muanza
Publisher : Frontiers Media SA
Release : 2020-01-22
ISBN : 2889633535
Language : En, Es, Fr & De

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Book Description :

Download Targeted Therapies for Glioblastoma A Critical Appraisal book written by Shiv K. Gupta,Sani H. Kizilbash,Thierry M. Muanza, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Advances in the Biology Imaging and Therapies for Glioblastoma

Advances in the Biology  Imaging and Therapies for Glioblastoma Book
Author : Clark Chen
Publisher : BoD – Books on Demand
Release : 2011-11-09
ISBN : 9533072849
Language : En, Es, Fr & De

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Book Description :

This book is intended for physicians and scientists with interest in glioblastoma biology, imaging and therapy. Select topics in DNA repair are presented here to demonstrate novel paradigms as they relate to therapeutic strategies. The book should serve as a supplementary text in courses and seminars as well as a general reference.

Glioblastoma Part I Surgical Management and Adjuncts An Issue of Neurosurgery Clinics of North America E Book

Glioblastoma  Part I  Surgical Management and Adjuncts  An Issue of Neurosurgery Clinics of North America  E Book Book
Author : Michael A Vogelbaum
Publisher : Elsevier Health Sciences
Release : 2021-02-12
ISBN : 032379095X
Language : En, Es, Fr & De

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Book Description :

This issue of Neurosurgery Clinics, guest edited by Dr. Michael A. Vogelbaum, is devoted to Glioblastoma, Part I: Surgical Management and Adjuncts. This is one of four issues selected each year by the series Consulting Editors, Russell R. Lonser and Daniel K. Resnick. Articles in this issue include: Perioperative Management of Patients with Glioblastoma, Role of Resection in Glioblastoma Management, Advancing Imaging to Enhance Surgery, Intraoperative Imaging for High-Grade Glioma Surgery, Use of Intraoperative Fluorophores, Extent of Resection of Glioblastoma, Functional Mapping for Glioma Surgery: Preoperative Mapping Tools, Functional Mapping for Glioma Surgery: Intraoperative Mapping Tools, Surgical Adjuncts for Glioblastoma, Window of Opportunity Clinical Trials to Evaluate Novel Therapies for Brain Tumors, Stereotactic Laser Ablation of Glioblastoma, Radiosurgery for Glioblastoma, Challenges Associated with Reoperation in Patients with Glioma, and Surgery for Glioblastoma in Elderly Patients.

Glioblastoma State of the Art and Future Perspectives

Glioblastoma  State of the Art and Future Perspectives Book
Author : Ghazaleh Tabatabai ,Hiroaki Wakimoto
Publisher : MDPI
Release : 2020-12-10
ISBN : 3039282603
Language : En, Es, Fr & De

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Book Description :

Glioblastoma is an aggressive incurable primary tumor of the central nervous system. Median overall survival is in the range of 1.5 years even in selected clinical trials populations. Many features contribute to this therapeutic challenge including high intratumoral and intertumoral heterogeneity, resistance to therapy, migration and invasion, immunosuppression. With the access of novel highthroughput technologies, significant progress has been made to understand molecular and immunological signatures underlying the pathology of glioblastoma. Clinical trial designs have shifted from investigating broad “one-for-all” treatment approaches to precision oncology designs. The collection of contributions in this book aim at providing researchers and clinicians an update on different aspects of glioblastoma, i.e. progress in basic, preclinical and clinical research.

Glioblastoma Multiforme

Glioblastoma Multiforme Book
Author : Isabelle Germano
Publisher : Unknown
Release : 2015-09-01
ISBN : 9781634832731
Language : En, Es, Fr & De

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Book Description :

This book provides basic researchers and clinicians with a contemporary review of personalised medicine for the diagnosis and treatment of Glioblastoma Multiforme (GBM), the most common and most aggressive type of brain tumor. Over the past decade, there has been an explosion of basic and clinical research revolving around GBM, resulting in improved outcomes and, most importantly, significant advances in our ability to better understand this disease to formulate personalised medical treatment for each patient. It is important to note that the word multiforme means of many forms or appearances, implying that one treatment will not fit all. Data from a variety of sources show that medical decisions and interventions must be tailored to the individual patient to obtain the greatest outcome. In this book, the diagnostic techniques and treatment options for patients with GBM are reviewed in state-of-the-art chapters written by expert researchers and clinicians in the field focusing on molecular genetic classification, surgical management, chemotherapy, radiation, nutrition, immune-therapy, and more. Many new therapeutic options are described and reviewed, confirming that not only does each patient needs to have personalised treatment, but also that a single treatment alone will not be sufficient; multiple mechanisms are involved and tumor biology changes over time. Hopefully, this book will educate and stimulate readers knowledge and lead to new avenues of investigation and therapeutic success.

Glioblastoma

Glioblastoma Book
Author : Steven Brem,Kalil G. Abdullah
Publisher : Elsevier
Release : 2016-09-01
ISBN : 9780323476607
Language : En, Es, Fr & De

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Book Description :

Clinically focused and designed to provide a to-the-point overview, Glioblastoma, by Drs. Steven Brem and Kalil G. Abdullah, brings you up to date with increased understanding, new treatment protocols, and recent advances in the field. Written by contributing specialists who are global experts in their respective areas, this one-stop reference provides neurosurgeons, medical-and-radiation oncologists, neuro-oncologists, neuropathologists, internal medicine physicians, and researchers with a dependable source of information on current treatment options, tumor recurrence, and patient care. Evidence for current treatment options for de novo and recurrent glioblastoma, indications for local and topical therapies, immunotherapy, gene therapy, nanotherapy, small-molecule inhibition, electric tumor treating field stimulation, and antiangiogenic therapies and the role of Avastin. Recent advances relating to tumor resection, such as stereotactic laser ablation, diffusion tensor imaging, and fluorescent markers. Prognostic molecular and genetic markers and the impact of gene mutations on survival, as well as controversies relating to pseudo-progression. Lessons learned from unsuccessful interventions, as well as the most promising aspects of future glioblastoma research and treatment. Expert ConsultT eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, and references from the book on a variety of devices.

Glioblastoma Part I Surgical Management and Adjuncts an Issue of Neurosurgery Clinics of North America

Glioblastoma  Part I  Surgical Management and Adjuncts  an Issue of Neurosurgery Clinics of North America Book
Author : Michael A Vogelbaum
Publisher : Elsevier
Release : 2021-02-12
ISBN : 9780323790949
Language : En, Es, Fr & De

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Book Description :

This issue of Neurosurgery Clinics, guest edited by Dr. Michael A. Vogelbaum, is devoted to Glioblastoma, Part I: Surgical Management and Adjuncts. This is one of four issues selected each year by the series Consulting Editors, Russell R. Lonser and Daniel K. Resnick. Articles in this issue include: Perioperative Management of Patients with Glioblastoma, Role of Resection in Glioblastoma Management, Advancing Imaging to Enhance Surgery, Intraoperative Imaging for High-Grade Glioma Surgery, Use of Intraoperative Fluorophores, Extent of Resection of Glioblastoma, Functional Mapping for Glioma Surgery: Preoperative Mapping Tools, Functional Mapping for Glioma Surgery: Intraoperative Mapping Tools, Surgical Adjuncts for Glioblastoma, Window of Opportunity Clinical Trials to Evaluate Novel Therapies for Brain Tumors, Stereotactic Laser Ablation of Glioblastoma, Radiosurgery for Glioblastoma, Challenges Associated with Reoperation in Patients with Glioma, and Surgery for Glioblastoma in Elderly Patients.