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Genomic Medicine In Emerging Economies

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Genomic Medicine in Emerging Economies

Genomic Medicine in Emerging Economies Book
Author : George Patrinos,Catalina Lopez-Correa
Publisher : Academic Press
Release : 2018-06-29
ISBN : 0128115513
Language : En, Es, Fr & De

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Book Description :

Genomic Medicine in Resource-limited Countries: Genomics for Every Nation provides in-depth analysis and key examples of the implementation of medical genomics in low-income nations across the globe, demonstrating how this advancing medical science has not only transformed health systems, but also led to improved patient care in Indonesian, Nepalese, Chilean, Malaysian, Tanzanian, Argentinian, Chinese, Sri Lankan and Columbian populations, among others. In addition to defining tools, diagnostics and treatment pathways at the population-wide level for medical geneticists, genomic researchers and public health workers, this book offers a case-study based approach that helps users understand how genomic medicine is used in disease-management. Examines essential concepts and protocols, and economic, social and legal considerations related to the implementation of genomic medicine in resource-limited nations Features concrete success stories of the implementation of medical genomics in Indonesian, Nepalese, Chilean, Malaysian, Tanzanian, Argentinian, Chinese, Sri Lankan and Columbian populations, amongst others Provides tools, diagnostics and treatment pathways for medical geneticists, genomic researchers and public health workers to apply in their own work Establishes clear precedents on how genomic technologies can be accessed by nations with limited means and financial support for healthcare

Economic Evaluation in Genomic Medicine

Economic Evaluation in Genomic Medicine Book
Author : Vasilios Fragoulakis,Christina Mitropoulou,Marc Williams,George Patrinos
Publisher : Academic Press
Release : 2015-03-25
ISBN : 9780128014974
Language : En, Es, Fr & De

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Book Description :

Economic Evaluation in Genomic Medicine introduces health economics and economic evaluation to genomic clinicians and researchers, while also introducing the topic to health economists. Each chapter includes an executive summary, questions, and case studies, along with supplementary online materials, including process guides, maps, flow charts, diagrams, and economic evaluation spreadsheets to enhance the learning process. The text can easily be used as course material for related graduate and undergraduate courses, providing a succinct overview of the existing, state-of-the-art application of economic evaluation to genomic healthcare and precision medicine. . Interrelates economic evaluation and genomic medicine . Instructs healthcare professionals and bioscientists about economic evaluation in genomic medicine . Teaches health economists about application of economic evaluation in genomic medicine . Introduces health economics and economic evaluation to clinicians and researchers involved in genomics . Includes process guides, maps, flow charts and diagrams

Genomics and Health in the Developing World

Genomics and Health in the Developing World Book
Author : Dhavendra Kumar
Publisher : Unknown
Release : 2012
ISBN : 9780199392995
Language : En, Es, Fr & De

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Book Description :

Genomics and Health in the Developing World provides detailed and comprehensive coverage of population structures, human genomics, and genome variation--with particular emphasis on medical and health issues--in the emerging economies and countries of the developing world. With sections dedicated to fundamtals of genetics and genomics, epidemiology of human disease, biomarkers, comparative genomics, developments in translational genomic medicine, current and future health strategies related to genetic disease, and pertinent legislative and social factors, this volume highlights the importance o.

Genomics and Health in the Developing World

Genomics and Health in the Developing World Book
Author : Dhavendra Kumar
Publisher : Oxford University Press
Release : 2012-05-11
ISBN : 019970547X
Language : En, Es, Fr & De

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Book Description :

Genomics and Health in the Developing World provides detailed and comprehensive coverage of population structures, human genomics, and genome variation--with particular emphasis on medical and health issues--in the emerging economies and countries of the developing world. With sections dedicated to fundamtals of genetics and genomics, epidemiology of human disease, biomarkers, comparative genomics, developments in translational genomic medicine, current and future health strategies related to genetic disease, and pertinent legislative and social factors, this volume highlights the importance of utilizing genetics/genomics knowledge to promote and achieve optimal health in the developing world. Grouped by geographic region, the chapters in this volume address: - Inherited disorders in the developing world, including a thorough look at genetic disorders in minority groups of every continent - The progress of diagnostic laboratory genetic testing, prenatal screening, and genetic counseling worldwide - Rising ethical and legal concerns of medical genetics in the developing world - Social, cultural, and religious issues related to genetic diseases across continents Both timely and vastly informative, this book is a unique and comprehensive resource for genetists, clinicians, and public health professionals interested in the social, ethical, economic, and legal matters associated with medical genetics in the developing world.

Educating Health Professionals in Genomic Medicine Evidence Based Strategies and Approaches

Educating Health Professionals in Genomic Medicine  Evidence Based Strategies and Approaches Book
Author : Sylvia Ann Metcalfe,Clara Gaff,Michael Dougherty
Publisher : Frontiers Media SA
Release : 2020-10-09
ISBN : 2889660591
Language : En, Es, Fr & De

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Book Description :

Download Educating Health Professionals in Genomic Medicine Evidence Based Strategies and Approaches book written by Sylvia Ann Metcalfe,Clara Gaff,Michael Dougherty, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Economic Evaluation in Genomic Medicine

Economic Evaluation in Genomic Medicine Book
Author : Vasilios Fragoulakis,Christina Mitropoulou,Marc Williams,George P. Patrinos
Publisher : Academic Press
Release : 2015-03-20
ISBN : 0128016116
Language : En, Es, Fr & De

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Book Description :

Economic Evaluation in Genomic Medicine introduces health economics and economic evaluation to genomic clinicians and researchers, while also introducing the topic to health economists. Each chapter includes an executive summary, questions, and case studies, along with supplementary online materials, including process guides, maps, flow charts, diagrams, and economic evaluation spreadsheets to enhance the learning process. The text can easily be used as course material for related graduate and undergraduate courses, providing a succinct overview of the existing, state-of-the-art application of economic evaluation to genomic healthcare and precision medicine. Interrelates economic evaluation and genomic medicine Instructs healthcare professionals and bioscientists about economic evaluation in genomic medicine Teaches health economists about application of economic evaluation in genomic medicine Introduces health economics and economic evaluation to clinicians and researchers involved in genomics Includes process guides, maps, flow charts and diagrams

Applied Genomics and Public Health

Applied Genomics and Public Health Book
Author : George P. Patrinos
Publisher : Academic Press
Release : 2019-11-13
ISBN : 0128136960
Language : En, Es, Fr & De

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Book Description :

Applied Genomics and Public Health examines the interdisciplinary and growing area of how evidence-based genomic knowledge can be applied to public health, population health, healthcare and health policies. The book gathers experts from a variety of disciplines, including life sciences, social sciences, and health care to develop a comprehensive overview of the field. In addition, the book delves into subjects such as pharmacogenomics, genethics, big data, data translation and analysis, economic evaluation, genomic awareness and education, sociology, pricing and reimbursement, policy measures and economic evaluation in genomic medicine. This book is essential reading for researchers and students exploring applications of genomics to population and public health. In addition, it is ideal for those in the biomedical sciences, medical sociologists, healthcare professionals, nurses, regulatory bodies and health economists interested in learning more about this growing field. Explores the growing application of genomics to population and public health Features internationally renowned contributors from a variety of related fields Contains chapters on important topics such as genomic data sharing, genethics and public health genomics, genomics and sociology, and regulatory aspects of genomic medicine and pharmacogenomics

Chapter 28 Genomics in Emerging and Developing Economies

Chapter 28 Genomics in Emerging and Developing Economies Book
Author : Duana Fullwiley,Martyn Pickersgill,Sahra Gibbon
Publisher : Unknown
Release : 2021-12-04
ISBN : 9781138211957
Language : En, Es, Fr & De

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Book Description :

Low and middle-income countries have become a site of increasing research interest and investment with the transnational expansion and spread of genomic knowledge and technologies (Kumar 2012, Seguin and others 2008). This reflects a dynamic terrain in which genomics is being harnessed to address a range of healthcare challenges.

Economic Dimensions of Personalized and Precision Medicine

Economic Dimensions of Personalized and Precision Medicine Book
Author : Ernst R. Berndt,Dana P. Goldman,John Rowe
Publisher : University of Chicago Press
Release : 2019-04-22
ISBN : 022661123X
Language : En, Es, Fr & De

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Book Description :

Personalized and precision medicine (PPM)—the targeting of therapies according to an individual’s genetic, environmental, or lifestyle characteristics—is becoming an increasingly important approach in health care treatment and prevention. The advancement of PPM is a challenge in traditional clinical, reimbursement, and regulatory landscapes because it is costly to develop and introduces a wide range of scientific, clinical, ethical, and socioeconomic issues. PPM raises a multitude of economic issues, including how information on accurate diagnosis and treatment success will be disseminated and who will bear the cost; changes to physician training to incorporate genetics, probability and statistics, and economic considerations; questions about whether the benefits of PPM will be confined to developed countries or will diffuse to emerging economies with less developed health care systems; the effects of patient heterogeneity on cost-effectiveness analysis; and opportunities for PPM’s growth beyond treatment of acute illness, such as prevention and reversal of chronic conditions. This volume explores the intersection of the scientific, clinical, and economic factors affecting the development of PPM, including its effects on the drug pipeline, on reimbursement of PPM diagnostics and treatments, and on funding of the requisite underlying research; and it examines recent empirical applications of PPM.

Genomics and Health in the Developing World

Genomics and Health in the Developing World Book
Author : Dhavendra Kumar
Publisher : Oxford University Press
Release : 2012-06-14
ISBN : 0195374754
Language : En, Es, Fr & De

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Book Description :

This book is designed to be the first major text to discuss advances in medical genetics in the developing world.

The Biologist s Imagination

The Biologist s Imagination Book
Author : William Hoffman,William R. Hoffman,Leo Furcht
Publisher : Oxford University Press, USA
Release : 2014
ISBN : 0199974594
Language : En, Es, Fr & De

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Book Description :

"Scholars and policymakers alike agree that innovation in the biosciences is key to future growth. The field continues to shift and expand, and it is certainly changing the way people live their lives in a variety of ways. But despite the lion's share offederal research dollars being devoted to innovation in the biosciences, the field has yet to live up to its billing as a source of economic productivity and growth. With vast untapped potential to imagine and innovate in the biosciences, adaptation of the innovative model is needed. In The Biologist's Imagination, William Hoffman and Leo Furcht examine the history of innovation in the biosciences, tracing technological innovation from the late eighteenth century to the present and placing special emphasis on how and where technology evolves. Place is key to innovation, from the early industrial age to the rise of the biotechnology industry in the second half of the twentieth century. The book uses the distinct history of bioscientific innovation to discuss current trends as they relate to medicine, agriculture, biofuels, stem-cell research, neuroscience, and more. Ultimately, Hoffman and Furcht argue that, as things currently stand, we fall short in our efforts to innovate in the biosciences; our system of innovation is itself in need of innovation. It needs to adapt to the massive changes brought about by converging technologies, globalization in higher education as well as in finance, and increases in entrepreneurship. The Biologist's Imagination is both an analysis of past models for bioscience innovation and a forward-looking, original argument for how future models should be developed"--

Genome Plasticity in Health and Disease

Genome Plasticity in Health and Disease Book
Author : Anonim
Publisher : Academic Press
Release : 2020-04-08
ISBN : 0128178205
Language : En, Es, Fr & De

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Book Description :

Genome Plasticity in Health and Disease provides a fully up-to-date overview on genome plasticity and its role in human physiology and disease. Following an introduction to the field, a diverse range of chapters cover genomic and epigenomic analysis and the use of model organisms and genomic databases in studies. Specific molecular and biochemical mechanisms of genome plasticity are examined, including somatic variants, De Novo variants, founder variations, isolated populations dynamics, copy-number variations, mobile elements, DNA methylation, histone modifications, transcription factors, non-coding RNAs, telomere dynamics and RNA editing. Later chapters explore disease relevance for cancer, as well as cardiovascular, neuropsychiatric, inflammatory, and endocrine disease, and associated pathways for drug discovery. Examines the role of genome plasticity across a range of disease types, from cardiovascular disease, to cancer and neuropsychiatric disorders Adopts an interdisciplinary approach, with expert contributions across the spectrum of basic science and disease relevance to drug discovery

Genomics and Society

Genomics and Society Book
Author : Dhavendra Kumar,Ruth Chadwick
Publisher : Academic Press
Release : 2015-10-29
ISBN : 0127999213
Language : En, Es, Fr & De

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Book Description :

Genomics and Society; Ethical, Legal-Cultural, and Socioeconomic Implications is the first book to address the vast and thorny web of ELSI topics identified as core priorities of the NHGRI in 2011. The work addresses fundamental issues of biosociety and bioeconomy as the revolution in biology moves from research lab to healthcare system. Of particular interest to healthcare practitioners, bioethicists, and health economists, and of tangential interest to the gamut of applied social scientists investigating the societal impact of new medical paradigms, the work describes a myriad of issues around consent, confidentiality, rights, patenting, regulation, and legality in the new era of genomic medicine. Addresses the vast and thorny web of ELSI topics identified as core priorities of the NHGRI in 2011 Presents the core fundamental issues of biosociety and bioeconomy as the revolution in biology moves from research lab to healthcare system Describes a myriad of issues around consent, including confidentiality, rights, patenting, regulation, and more

Routledge Handbook of Genomics Health and Society

Routledge Handbook of Genomics  Health and Society Book
Author : Sahra Gibbon,Barbara Prainsack,Stephen Hilgartner,Janelle Lamoreaux
Publisher : Routledge
Release : 2018-04-17
ISBN : 1315451670
Language : En, Es, Fr & De

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Book Description :

The Handbook provides an essential resource at the interface of Genomics, Health and Society, and forms a crucial research tool for both new students and established scholars across biomedicine and social sciences. Building from and extending the first Routledge Handbook of Genetics and Society, the book offers a comprehensive introduction to pivotal themes within the field, an overview of the current state of the art knowledge on genomics, science and society, and an outline of emerging areas of research. Key themes addressed include the way genomic based DNA technologies have become incorporated into diverse arenas of clinical practice and research whilst also extending beyond the clinic; the role of genomics in contemporary ‘bioeconomies’; how challenges in the governance of medical genomics can both reconfigure and stabilise regulatory processes and jurisdictional boundaries; how questions of diversity and justice are situated across different national and transnational terrains of genomic research; and how genomics informs – and is shaped by – developments in fields such as epigenetics, synthetic biology, stem cell, microbial and animal model research. Presenting cutting edge research from leading social science scholars, the Handbook provides a unique and important contribution to the field. It brings a rich and varied cross disciplinary social science perspective that engages with both the history and contemporary context of genomics and ‘post-genomics’, and considers the now global and transnational terrain in which these developments are unfolding.

Bringing Leadership to Life in Health LEADS in a Caring Environment

Bringing Leadership to Life in Health  LEADS in a Caring Environment Book
Author : Graham Dickson,Bill Tholl
Publisher : Springer Nature
Release : 2020-03-06
ISBN : 3030385361
Language : En, Es, Fr & De

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Book Description :

This edited volume, featuring five new chapters from invited authors, provides an updated and evidence-based explanation of leadership within a healthcare environment. The book discusses new insights garnered from recent research into the importance of leadership in health system redesign and highlights the practice of shared or distributed health care leadership. New chapters covering LEADS in a national, regional, Indigenous, health profession, and people-centred care context provide new insights into how LEADS is being put to work to transform health systems. The LEADS framework has been refreshed in relation to each of its different elements and tools, with an emphasis on providing real-life examples of how LEADS has been put to work. LEADS is also explained as a change leadership model and in relation to how it helps to level the playing field in terms of gender and diversity in health leadership. The book aims to inform the leadership needs of health reform and its emergent system wide challenges. The content is relevant to health care administrators and professionals working within the public service, academic institutions, and health care delivery organisations.

Endocrine System Diseases New Insights for the Healthcare Professional 2013 Edition

Endocrine System Diseases  New Insights for the Healthcare Professional  2013 Edition Book
Author : Anonim
Publisher : ScholarlyEditions
Release : 2013-07-22
ISBN : 1481658484
Language : En, Es, Fr & De

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Book Description :

Endocrine System Diseases: New Insights for the Healthcare Professional: 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about Diagnosis and Screening. The editors have built Endocrine System Diseases: New Insights for the Healthcare Professional: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Diagnosis and Screening in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Endocrine System Diseases: New Insights for the Healthcare Professional: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Global Clinical Trials for Alzheimer s Disease

Global Clinical Trials for Alzheimer   s Disease Book
Author : Sidney A. Spector
Publisher : Elsevier Inc. Chapters
Release : 2013-08-28
ISBN : 0128070552
Language : En, Es, Fr & De

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Book Description :

The burgeoning field of pharmacogenomics holds the promise to uncover genetic risk factors for both rare and common diseases, identify genetically based inter-individual responses to medicines, and enrich clinical trials with more genetically homogeneous groups, with the overarching goal to provide safer and more effective medicines to individuals and populations. With the sequencing of the human genome at the turn of the twentieth century, this last decade has seen an explosion in the development of technologies and methods to advance our understanding of the genetic underpinnings of disease and how individuals respond to medicines. In the field of Alzheimer’s disease research, pharmacogenomics has provided insight into the genetic complexity of this common disorder, confirming ApoE carrier status as a genetic determinant of risk for this disease, as well as identifying many other possible gene candidates. Recognition of global genetic diversity, however, requires that these methods be applied to different ethnic and racial groups throughout the world. Collaborations between academia, non-government organizations, and the pharmaceutical industry under the guidance and regulation of government-directed institutes and initiatives have been created in underdeveloped and developing countries in Africa, Asia, and Central and South America to identify unique genetic variation that will guide the development and use of medicines in these populations. Though each local population and government has its own set of economic, social, legal, regulatory and ethical challenges, the overarching goal in this endeavor is the translation of pharmacogenomic knowledge into the development of safer and more effective medicines for patients throughout the world.

Essentials of Medical Genomics

Essentials of Medical Genomics Book
Author : Stuart M. Brown,John G. Hay,Harry Ostrer
Publisher : John Wiley & Sons
Release : 2008-12-29
ISBN : 0470334495
Language : En, Es, Fr & De

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Book Description :

Six new chapters on vital topics of interest such as multilocus SNP genotyping (SNP chips), RNAi, ChIP-chip, and genomic tiling arrays New edition responds to reviewers' and users' desire for greater coverage—now the most useful handbook on the market! Practical, concise summary of everything about genomics and emerging technologies a busy physician or medical student should know Covers concepts and techniques that are in use in medicine now, as well as those on the cutting-edge of science relevant to medicine, from bioinformatics to DNA diagnostics and proteomics NEW: Includes chapter-end exercises, enhancing the utility of the new edition as a textbook NEW: PowerPoint slides of images available at instructor website

Genomics Applications for the Developing World

Genomics Applications for the Developing World Book
Author : Karen E. Nelson,Barbara Jones-Nelson
Publisher : Springer Science & Business Media
Release : 2012-05-10
ISBN : 1461421829
Language : En, Es, Fr & De

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Book Description :

This book evolved from the editors strong belief that the information and new developments that were evolving from the rapidly growing field of genomics and that are happening primarily in the developed world have not happened at a parallel rate in the developing world. One would have hoped that by now the technologies and approaches would have been adapted on a far greater scale. In addition to this, the associated information is not always easily accessible, and is not disseminated in a format that can become a useful reference for scientists, students and others who reside in developing countries.

Global Clinical Trials for Alzheimer s Disease

Global Clinical Trials for Alzheimer s Disease Book
Author : Menghis Bairu,Michael Weiner
Publisher : Academic Press
Release : 2013-08-28
ISBN : 0124115306
Language : En, Es, Fr & De

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Book Description :

Global Clinical Trials for Alzheimer’s Disease is a handy one-stop reference for researchers and physicians planning and conducting global clinical trials in this area. This book addresses important considerations that may arise during the successful design and execution of these trials, including site selection, local regulatory issues, pharmacogenomics, ethical matters and much more. Given the saturation of traditional clinical trial markets and the worldwide progression of Alzheimer’s disease, there is a need to focus on clinical trials in emerging markets and developing countries. This book provides you with a practical approach to recognizing the opportunities and tackling the challenges that are present during the planning and execution of global clinical trials for Alzheimer’s disease. Written by leading experts with hands-on experience in designing and running global Alzheimer’s disease and other neurodegenerative diseases clinical trials A step-by-step guide that provides critical information on the design, conduct and standardization necessary to effectively execute clinical trials and accelerate drug development in this area Includes practical examples, ethical considerations, lessons learned and other valuable tools to aid the planning and implementation of Alzheimer’s disease global clinical trials in emerging markets and developing countries