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Genomic Control Process

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Genomic Control Process

Genomic Control Process Book
Author : Isabelle Peter,Eric H. Davidson
Publisher : Academic Press
Release : 2015-01-21
ISBN : 0124047467
Language : En, Es, Fr & De

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Book Description :

Genomic Control Process explores the biological phenomena around genomic regulatory systems that control and shape animal development processes, and which determine the nature of evolutionary processes that affect body plan. Unifying and simplifying the descriptions of development and evolution by focusing on the causality in these processes, it provides a comprehensive method of considering genomic control across diverse biological processes. This book is essential for graduate researchers in genomics, systems biology and molecular biology seeking to understand deep biological processes which regulate the structure of animals during development. Covers a vast area of current biological research to produce a genome oriented regulatory bioscience of animal life Places gene regulation, embryonic and postembryonic development, and evolution of the body plan in a unified conceptual framework Provides the conceptual keys to interpret a broad developmental and evolutionary landscape with precise experimental illustrations drawn from contemporary literature Includes a range of material, from developmental phenomenology to quantitative and logic models, from phylogenetics to the molecular biology of gene regulation, from animal models of all kinds to evidence of every relevant type Demonstrates the causal power of system-level understanding of genomic control process Conceptually organizes a constellation of complex and diverse biological phenomena Investigates fundamental developmental control system logic in diverse circumstances and expresses these in conceptual models Explores mechanistic evolutionary processes, illuminating the evolutionary consequences of developmental control systems as they are encoded in the genome

The Regulatory Genome

The Regulatory Genome Book
Author : Eric H. Davidson
Publisher : Elsevier
Release : 2010-07-19
ISBN : 9780080455570
Language : En, Es, Fr & De

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Book Description :

Gene regulatory networks are the most complex, extensive control systems found in nature. The interaction between biology and evolution has been the subject of great interest in recent years. The author, Eric Davidson, has been instrumental in elucidating this relationship. He is a world renowned scientist and a major contributor to the field of developmental biology. The Regulatory Genome beautifully explains the control of animal development in terms of structure/function relations of inherited regulatory DNA sequence, and the emergent properties of the gene regulatory networks composed of these sequences. New insights into the mechanisms of body plan evolution are derived from considerations of the consequences of change in developmental gene regulatory networks. Examples of crucial evidence underscore each major concept. The clear writing style explains regulatory causality without requiring a sophisticated background in descriptive developmental biology. This unique text supersedes anything currently available in the market. The only book in the market that is solely devoted to the genomic regulatory code for animal development Written at a conceptual level, including many novel synthetic concepts that ultimately simplify understanding Presents a comprehensive treatment of molecular control elements that determine the function of genes Provides a comparative treatment of development, based on principles rather than description of developmental processes Considers the evolutionary processes in terms of the structural properties of gene regulatory networks Includes 42 full-color descriptive figures and diagrams

Decoding the Genomic Control of Immune Reactions

Decoding the Genomic Control of Immune Reactions Book
Author : Gregory R. Bock,Jamie A. Goode
Publisher : John Wiley & Sons
Release : 2007-04-04
ISBN : 9780470062111
Language : En, Es, Fr & De

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Book Description :

This book explores existing and potential strategies for using the genome sequences of human, mouse, other vertebrates and human pathogens to solve key problems in the treatment of immunological diseases and chronic infections. The assembled genome sequences now provide important opportunities for solving these problems, but a major bottleneck is the identification of key sequences and circuits controlling the relevant immune reactions. This will require innovative, interdisciplinary and collaborative strategies of a scale and complexity we are only now beginning to comprehend. Specific problems addressed include the following: What kinds of information are we lacking to understand how the genome sequence specifies the differentiation and response of immune system cells, and system behaviour such as immunological memory and tolerance? Which genome sequences and cellular circuits cause or prevent pathological immune responses to foreign pathogens, allergens or self-tissues? Which host and pathogen genome sequences and cellular circuits explain the failure of sterilizing immune responses to sophisticated human pathogens such as the agents of tuberculosis, malaria, metazoan parasites and chronic viruses? Containing contributions from a range of leading experts in the field, this book provides an important new perspective for clinical immunologists and basic researchers alike.

Genetic Control of Salivary Duct Development in Drosophila Melanogaster

Genetic Control of Salivary Duct Development in Drosophila Melanogaster Book
Author : Nikolas Alexander Jones
Publisher : Unknown
Release : 1998
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Genetic Control of Salivary Duct Development in Drosophila Melanogaster book written by Nikolas Alexander Jones, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Mosby s Medical Dictionary

Mosby s Medical Dictionary Book
Author : Mosby
Publisher : Elsevier
Release : 2016-05-06
ISBN : 9780323414258
Language : En, Es, Fr & De

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Book Description :

Download Mosby s Medical Dictionary book written by Mosby, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Philosophy of Systems Biology

Philosophy of Systems Biology Book
Author : Sara Green
Publisher : Springer
Release : 2016-12-15
ISBN : 3319470000
Language : En, Es, Fr & De

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Book Description :

The emergence of systems biology raises many fascinating questions: What does it mean to take a systems approach to problems in biology? To what extent is the use of mathematical and computational modelling changing the life sciences? How does the availability of big data influence research practices? What are the major challenges for biomedical research in the years to come? This book addresses such questions of relevance not only to philosophers and biologists but also to readers interested in the broader implications of systems biology for science and society. The book features reflections and original work by experts from across the disciplines including systems biologists, philosophers, and interdisciplinary scholars investigating the social and educational aspects of systems biology. In response to the same set of questions, the experts develop and defend their personal perspectives on the distinctive character of systems biology and the challenges that lie ahead. Readers are invited to engage with different views on the questions addressed, and may explore numerous themes relating to the philosophy of systems biology. This edited work will appeal to scholars and all levels, from undergraduates to researchers, and to those interested in a variety of scholarly approaches such as systems biology, mathematical and computational modelling, cell and molecular biology, genomics, systems theory, and of course, philosophy of biology.

Molecular Mechanisms of Precise and Robust Gene Regulation in Drosophila

Molecular Mechanisms of Precise and Robust Gene Regulation in Drosophila Book
Author : Alistair Nicol Boettiger
Publisher : Unknown
Release : 2011
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

The ornate arrangement of diverse cells into specialized tissues, organs, and higher structures characteristic of multicellular organisms is all encoded from the same genome sequence. Despite their differences, morphologically distinct cells (e.g. muscle cells and neurons) must transcribe many of the same genes. Morphological indistinguishable cells must often transcribe distinct sets of genes (e.g. different odorant receptor cells). The ensemble of genes expressed in a given cell -- and the relative frequency they are expressed at, give each cell its characteristic identity more so than the presence of individual genes. Therefore understanding the genetic control of development and differentiation is a question not so much of the understanding the gene sequences themselves, but the regulatory structure of the genome which determines how they are deployed. In order for development to unravel in such a manner that each embryo makes it through the process with all the correct parts in the correct positions at the end, this process must be exceedingly precise. Though often taken for granted, this precision becomes particular impressive if one considers the frequency with which mistakes are made in intelligently designed human built assembly processes. The developing animal must position components correctly on scales of microns (e.g. tissue boundaries) and nanometers (e.g. neuron-junctions), has no external direction of assembly, and requires thermal noise to position many of its components (including essentially all transcription factors - proteins which regulate read access to the genome). It is not sufficient for the process to be precise. It must also be robust to changes in the conditions in which it operates, such as different thermal environments, nutrient conditions, and chemical environments. This robustness enables a certain degree of plasticity, such that some components of the system can change and evolve new functions, without causing catastrophic failure of the rest of the system. In my thesis research I have tried to explore some of the molecular mechanisms of gene regulation which support the precise and robust expression of multicellular genomes. Rapid advances in post-genomic technologies have exposed a broad range of fundamental differences in the organization and regulation of multicellular genomes such as Drosophila. I have worked primarily on two phenomena, the use of promoter proximal pausing as a regulatory strategy, and the use of multiple apparently redundant regulatory sequences to drive expression of the same gene. Discovery of both of these phenomena emerged from analysis of whole genome polymerase and transcription factor binding data. Using quantitative high resolution in situ and semi-automated computational image processing I have studied the detailed differences in the transcriptional activation and transcription frequency of genes regulated by these mechanisms. Through this analysis I have shown a strong correlation through more rapid and synchronous gene expression and regulation through release of promoter proximal paused polymerase. Theoretical modeling demonstrates that such an effect can be expected from regulating release of stable downstream state in a general assembly process (such as construction of the RNA Pol II pre-initiation complex). Analysis of gene expression driven by multiple enhancers with overlapping activity compared to constructs with only a single active enhancer revealed that the process by which an enhancer binds its target transcription factors and activates expression is often limiting enough that having a second independent copy can produce detectable changes in the frequency of transcription. This reduction of natural variation in gene activation is especially important under stress conditions, such as thermal stress or reduced levels of some of the activating factors. Robustness to this sort of variation may be important both for adaptation within a species and the flexibility to allow modification of interacting pathways in the course of evolutionary modification. These investigations also revealed a corrective propensity whereby the simultaneous activity of multiple enhancers, responding to repressors as well as activators, can give rise to correctly restricted gene expression even when the elements taken in isolation drive some degree of ectopic expression. So far both of these mechanisms have only been reliably documented in multicellular systems, suggesting that the precision and robustness they confer may be an innovation of metazoans in response to increased levels of coordination required to keep many cells functioning in the tight cooperation of a multicellular organism. Doubtless this is but scratching the surface of the mechanisms which ensure such precision and control. However the rapid improvements to both genomic tools and imaging technology make it like to be a promising field for further exploration for years to come.

The Fractal Brain Theory

The Fractal Brain Theory Book
Author : Wai Tsang
Publisher : Lulu.com
Release : 2021-08-01
ISBN : 1326753223
Language : En, Es, Fr & De

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Book Description :

Download The Fractal Brain Theory book written by Wai Tsang, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Control Mechanisms of Growth and Differentiation

Control Mechanisms of Growth and Differentiation Book
Author : Society for Experimental Biology (Great Britain)
Publisher : Unknown
Release : 1971
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Control Mechanisms of Growth and Differentiation book written by Society for Experimental Biology (Great Britain), available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Statistical Methods in Genetic Epidemiology

Statistical Methods in Genetic Epidemiology Book
Author : Duncan C. Thomas
Publisher : Oxford University Press
Release : 2004-01-29
ISBN : 9780199748051
Language : En, Es, Fr & De

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Book Description :

This well-organized and clearly written text has a unique focus on methods of identifying the joint effects of genes and environment on disease patterns. It follows the natural sequence of research, taking readers through the study designs and statistical analysis techniques for determining whether a trait runs in families, testing hypotheses about whether a familial tendency is due to genetic or environmental factors or both, estimating the parameters of a genetic model, localizing and ultimately isolating the responsible genes, and finally characterizing their effects in the population. Examples from the literature on the genetic epidemiology of breast and colorectal cancer, among other diseases, illustrate this process. Although the book is oriented primarily towards graduate students in epidemiology, biostatistics and human genetics, it will also serve as a comprehensive reference work for researchers. Introductory chapters on molecular biology, Mendelian genetics, epidemiology, statistics, and population genetics will help make the book accessible to those coming from one of these fields without a background in the others. It strikes a good balance between epidemiologic study designs and statistical methods of data analysis.

The Encyclopaedia of Sports Medicine Genetic and Molecular Aspects of Sports Performance

The Encyclopaedia of Sports Medicine  Genetic and Molecular Aspects of Sports Performance Book
Author : Claude Bouchard,Eric P. Hoffman
Publisher : John Wiley & Sons
Release : 2011-08-02
ISBN : 1444348299
Language : En, Es, Fr & De

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Book Description :

This is the latest volume in the IOC Encyclopaedia of Sports Medicine series, summarizing the evidence from all relevant sources on the genetic and molecular basis of sports and other human physical performance. The initial chapters address the basic science of genomics and genetics and the regulation of gene expression. Additional chapters provide authoritative information on the genetics of complex performance phenotypes, the contributions of small animal research, family and twin studies, and ethnic comparisons. A final section addresses the issue of the contribution of specific genes and molecular markers as related to endurance, strength and power, and responsiveness to specific conditioning programs. This latest volume in the Encyclopaedia of Sports Medicine Series from the Medical Commission of the International Olympic Committee is a must for sports and exercise scientists who require a thorough guide to the most cutting edge science in this expanding field.

A Decade of Neuropeptides

A Decade of Neuropeptides Book
Author : George F. Koob,Curt A. Sandman,Fleur L. Strand
Publisher : Unknown
Release : 1990
ISBN : 9780897665636
Language : En, Es, Fr & De

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Book Description :

Download A Decade of Neuropeptides book written by George F. Koob,Curt A. Sandman,Fleur L. Strand, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Echinoderms

Echinoderms Book
Author : Anonim
Publisher : Academic Press
Release : 2019-04-02
ISBN : 0128170735
Language : En, Es, Fr & De

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Book Description :

Echinoderms, Volume 151, the latest release in the Methods in Cell Biology series, highlights advances in the field, with this update presenting chapters on Echinoderm Genome Databases, analysis of gene regulatory networks, using ATAC-seq and RNA-seq to increase resolution in GRN connectivity, multiplex cis-regulatory analysis, experimental approaches GRN/signal pathways, BACs, analysis of chromatin accessibility using ATAC-seq, analysis of sea urchin proteins /Click IT, CRISPR/Cas9-mediated genome editing in sea urchins, super-resolution and in toto imaging of echinoderm embryos, and methods for analysis of intracellular ion signals in sperm, eggs and embryos. Presents clear, concise protocols provided by experts who have established the echinoderms as a model systems Highlights new advances in the field, with this update presenting interesting chapters on echinoderms

Genetic Control of Malaria and Dengue

Genetic Control of Malaria and Dengue Book
Author : Zach N. Adelman
Publisher : Academic Press
Release : 2015-10-15
ISBN : 0128004053
Language : En, Es, Fr & De

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Book Description :

Genetic Control of Malaria and Dengue focuses on the knowledge, technology, regulation and ethics of using genetically modified mosquitoes to interrupt the transmission of important vector-borne diseases including Malaria. It contains coverage of the current state of knowledge of vector-borne diseases and how they are currently controlled; vaccine, drug and insecticide development; various strategies for altering the genome of mosquitoes in beneficial ways; and the regulatory, ethical and social environment concerning these strategies. For more than five decades, the prospect of using genetically-modified mosquitoes to control vector-borne disease transmission has been a purely hypothetical scenario. We simply did not have the technology or basic knowledge to be able to do it. With the explosion of field trials and potential interventions in development, Genetic Control of Malaria and Dengue provides a comprehensive overview of research in genetics, microbiology, virology, and ecology involved in the development and implementation of genetic modification programs for virus and disease control. This book is meant to provide a practical guide to researchers, regulators and the general public about how this technology actually works, how it can be improved, and what is still unknown. Includes coverage of vectorial capacity, critical to understanding vector-borne disease transmission Provides a summary of the concepts of both population suppression and population replacement Contains pivotal coverage of ethical and ecological ramifications of genetics-based control strategies

Phenotypic Switching

Phenotypic Switching Book
Author : Herbert Levine,Mohit Kumar Jolly,Prakash Kulkarni,Vidyanand Nanjundiah
Publisher : Academic Press
Release : 2020-06-10
ISBN : 012817997X
Language : En, Es, Fr & De

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Book Description :

Phenotypic Switching: Implications in Biology and Medicine provides a comprehensive examination of phenotypic switching across biological systems, including underlying mechanisms, evolutionary significance, and its role in biomedical science. Contributions from international leaders discuss conceptual and theoretical aspects of phenotypic plasticity, its influence over biological development, differentiation, biodiversity, and potential applications in cancer therapy, regenerative medicine and stem cell therapy, among other treatments. Chapters discuss fundamental mechanisms of phenotypic switching, including transition states, cell fate decisions, epigenetic factors, stochasticity, protein-based inheritance, specific areas of human development and disease relevance, phenotypic plasticity in melanoma, prostate cancer, breast cancer, non-genetic heterogeneity in cancer, hepatitis C, and more. This book is essential for active researchers, basic and translational scientists, clinicians, postgraduates and students in genetics, human genomics, pathology, bioinformatics, developmental biology, evolutionary biology and adaptive opportunities in yeast. Thoroughly addresses the conceptual, experimental and translational aspects that underlie phenotypic plasticity Emphasizes quantitative approaches, nonlinear dynamics, mechanistic insights and key methodologies to advance phenotypic plasticity studies Features a diverse range of chapter contributions from international leaders in the field

The Theory of Evolution

The Theory of Evolution Book
Author : Samuel M. Scheiner,David P. Mindell
Publisher : University of Chicago Press
Release : 2020-01-07
ISBN : 022667116X
Language : En, Es, Fr & De

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Book Description :

Darwin’s nineteenth-century writings laid the foundations for modern studies of evolution, and theoretical developments in the mid-twentieth century fostered the Modern Synthesis. Since that time, a great deal of new biological knowledge has been generated, including details of the genetic code, lateral gene transfer, and developmental constraints. Our improved understanding of these and many other phenomena have been working their way into evolutionary theory, changing it and improving its correspondence with evolution in nature. And while the study of evolution is thriving both as a basic science to understand the world and in its applications in agriculture, medicine, and public health, the broad scope of evolution—operating across genes, whole organisms, clades, and ecosystems—presents a significant challenge for researchers seeking to integrate abundant new data and content into a general theory of evolution. This book gives us that framework and synthesis for the twenty-first century. The Theory of Evolution presents a series of chapters by experts seeking this integration by addressing the current state of affairs across numerous fields within evolutionary biology, ranging from biogeography to multilevel selection, speciation, and macroevolutionary theory. By presenting current syntheses of evolution’s theoretical foundations and their growth in light of new datasets and analyses, this collection will enhance future research and understanding.

Chordate Origins and Evolution

Chordate Origins and Evolution Book
Author : Noriyuki Satoh
Publisher : Academic Press
Release : 2016-07-14
ISBN : 0128030062
Language : En, Es, Fr & De

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Book Description :

Chordate Origins and Evolution: The Molecular Evolutionary Road to Vertebrates focuses on echinoderms (starfish, sea urchins, and others), hemichordates (acorn worms, etc.), cephalochordates (lancelets), urochordates or tunicates (ascidians, larvaceans and others), and vertebrates. In general, evolution of these groups is discussed independently, on a larger scale: ambulacrarians (echi+hemi) and chordates (cephlo+uro+vert). Until now, discussion of these topics has been somewhat fragmented, and this work provides a unified presentation of the essential information. In the more than 150 years since Charles Darwin proposed the concept of the origin of species by means of natural selection, which has profoundly affected all fields of biology and medicine, the evolution of animals (metazoans) has been studied, discussed, and debated extensively. Following many decades of classical comparative morphology and embryology, the 1980s marked a turning point in studies of animal evolution, when molecular biological approaches, including molecular phylogeny (MP), molecular evolutionary developmental biology (evo-devo), and comparative genomics (CG), began to be employed. There are at least five key events in metazoan evolution, which include the origins of 1) diploblastic animals, such as cnidarians; 2) triploblastic animals or bilaterians; 3) protostomes and deuterostomes; 4) chordates, among deuterostomes; and 5) vertebrates, among chordates. The last two have received special attention in relation to evolution of human beings. During the past two decades, great advances have been made in this field, especially in regard to molecular and developmental mechanisms involved in the evolution of chordates. For example, the interpretation of phylogenetic relationships among deuterostomes has drastically changed. In addition, we have now obtained a large quantity of MP, evo-devo, and CG information on the origin and evolution of chordates. Covers the most significant advances in this field to give readers an understanding of the interesting biological issues involved Provides a unified presentation of essential information regarding each phylum and an integrative understanding of molecular mechanisms involved in the origin and evolution of chordates Discusses the evolutionary scenario of chordates based on two major characteristic features of animals—namely modes of feeding (energy sources) and reproduction—as the two main forces driving animal evolution and benefiting dialogue for future studies of animal evolution

3D Molecular Cytological and Genetic Analysis of the Sun Domain Sad1 Unc 84 Proteins in Maize Zea Mays L Meiosis Discovery of a Novel Plant SUN Family Including SUN3 a Candidate Gene for the Desynaptic dy Mutant

3D Molecular Cytological and Genetic Analysis of the Sun Domain  Sad1 Unc 84  Proteins in Maize  Zea Mays  L   Meiosis  Discovery of a Novel Plant SUN Family  Including SUN3  a Candidate Gene for the Desynaptic  dy  Mutant Book
Author : Shaun Patrick Murphy
Publisher : Unknown
Release : 2011
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

ABSTRACT: Meiosis is the process by which sexually reproducing organisms reduce their genomes from diploid (2n) to haploid (n) during the formation of gametes. It requires that homologous chromosomes pair, synapse, recombine, and finally segregate. These widely conserved processes are under genetic control, yet the exact details of many of the underlying molecular mechanisms remain under active investigation. The initial pairing and subsequent synapsis events are immediately preceded by the clustering of telomeres on the nuclear envelope in a widely conserved structure referred to as the bouquet arrangement of meiotic chromosomes. In animals and plants, genes required for genome reduction at meiosis I have been characterized and show a high degree of conservation between kingdoms and species within them. Higher plants (most notably maize) have provided an excellent large-genome model system for the study of the cytology of homologous chromosome behavior and therefore have allowed an in depth dissection of the meiotic process in eukaryotes. At the cellular level, meiotic chromosome behavior is accompanied by changes in the architecture of the cell nucleus, particularly with respect to the interaction of telomeres with the nuclear periphery. This dissertation presents the work involving the analysis of a classic meiotic mutant of maize, desynaptic (dy1). The dy1 mutant is characterized by a precocious telomere-nuclear envelope detachment phenotype at mid prophase, resulting in chromosome breaks, anaphase bridges, micronuclei, and defective pollen development. In this study, we observed new phenotypes as early as the telomere bouquet stage of meiotic prophase in dy1 lines of maize. Using linkage and translocation mapping techniques, the dy1 mutation was mapped to the long arm of chromosome 3, where a candidate gene with homology to a nuclear envelope associated SUN domain protein gene was identified. SUN (Sad1p/Unc-84) domain proteins function with other proteins to form a physical link between the nucleoskeleton and the cytoskeleton. These bridges transfer forces across the nuclear envelope and are increasingly recognized to play roles in nuclear positioning, nuclear migration, cell cycle-dependent breakdown and reformation of the nuclear envelope, telomere-led nuclear reorganization during meiosis, and karyogamy. Using bioinformatic and molecular approaches, we characterized the family of maize SUN-domain proteins, starting with a screen of maize genomic sequence data. We characterized five different maize ZmSUN genes (ZmSUN1-5), which fell into two structural classes likely of ancient origin. Orthologs of these genes and prevalent in the plant kingdom as they are also found in other monocots, eudicots, and even mosses. The first class described here designated canonical C-terminal SUN-domain (CCSD, ZmSUN1 and ZmSUN2), includes structural homologs of the animal and fungal SUNdomain protein genes. The second class, the plant-prevalent mid-SUN 3 transmembrane (PM3, ZmSUN3-5), includes a novel but conserved structural variant SUN-domain protein gene class. Analysis of the expression levels for these genes revealed very low expression in multiple tissue types, with the exception of ZmSUN5 which showed a pollen=preferred expression profile. Cloning and Peptide antibodies specific for ZmSUN3, and ZmSUN4 were used in western-blot and cell-staining assays to show that they are expressed and show concentrated staining at the nuclear periphery. In order to characterize the CCSD class of SUN proteins, we obtained new reagents and performed immunolocalization analyses coupled with high resolution 3D deconvolution microscopy. We identified a novel structure at the maize nuclear periphery we refer to as the "Nuclear SUN Belt", NSB, which was present in multiple somatic cell types as well as meiotic nuclei. During meiosis, the NSB was present at the onset and well into the leptotene stage of meiotic prophase. Surprisingly at the bouquet stage the NSB appeared to be localized opposite of the nucleolus in a crescent shape, occupying a small region (

Hearing Science

Hearing Science Book
Author : Charles I. Berlin
Publisher : Unknown
Release : 1984
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Hearing Science book written by Charles I. Berlin, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Genomic Signal Processing and Statistics

Genomic Signal Processing and Statistics Book
Author : Edward R. Dougherty
Publisher : Hindawi Publishing Corporation
Release : 2005
ISBN : 9775945070
Language : En, Es, Fr & De

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Book Description :

Recent advances in genomic studies have stimulated synergetic research and development in many cross-disciplinary areas. Processing the vast genomic data, especially the recent large-scale microarray gene expression data, to reveal the complex biological functionality, represents enormous challenges to signal processing and statistics. This perspective naturally leads to a new field, genomic signal processing (GSP), which studies the processing of genomic signals by integrating the theory of signal processing and statistics. Written by an international, interdisciplinary team of authors, this invaluable edited volume is accessible to students just entering this emergent field, and to researchers, both in academia and in industry, in the fields of molecular biology, engineering, statistics, and signal processing. The book provides tutorial-level overviews and addresses the specific needs of genomic signal processing students and researchers as a reference book. The book aims to address current genomic challenges by exploiting potential synergies between genomics, signal processing, and statistics, with special emphasis on signal processing and statistical tools for structural and functional understanding of genomic data. The first part of this book provides a brief history of genomic research and a background introduction from both biological and signal-processing/statistical perspectives, so that readers can easily follow the material presented in the rest of the book. In what follows, overviews of state-of-the-art techniques are provided. We start with a chapter on sequence analysis, and follow with chapters on feature selection, classification, and clustering of microarray data. We then discuss the modeling, analysis, and simulation of biological regulatory networks, especially gene regulatory networks based on Boolean and Bayesian approaches. Visualization and compression of gene data, and supercomputer implementation of genomic signal processing systems are also treated. Finally, we discuss systems biology and medical applications of genomic research as well as the future trends in genomic signal processing and statistics research.