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Genetics Of Bone Biology And Skeletal Disease

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Genetics of Bone Biology and Skeletal Disease

Genetics of Bone Biology and Skeletal Disease Book
Author : Rajesh V. Thakker,Michael P. Whyte,John Eisman,Takashi Igarashi
Publisher : Academic Press
Release : 2017-10-31
ISBN : 0128041986
Language : En, Es, Fr & De

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Book Description :

Genetics of Bone Biology and Skeletal Disease, Second Edition, is aimed at students of bone biology and genetics and includes general introductory chapters on bone biology and genetics. More specific disease orientated chapters comprehensively summarize the clinical, genetic, molecular, animal model, molecular pathology, diagnostic, counseling, and treatment aspects of each disorder. The book is organized into five sections that each emphasize a particular theme, general background to bone biology, general background to genetics and epigenetics, disorders of bone and joint, parathyroid and related disorders, and vitamin D and renal disorders. The first section is specifically devoted to providing an overview of bone biology and structure, joint and cartilage biology, principles of endocrine regulation of bone, and the role of neuronal regulation and energy homeostasis. The second section reviews the principles and progress of medical genetics and epigenetics related to bone disease, including genome-wide association studies (GWAS), genomic profiling, copy number variation, prospects of gene therapy, pharmacogenomics, genetic testing and counseling, as well as the generation and utilizing of mouse models. The third section details advances in the genetics and molecular biology of bone and joint diseases, both monogenic and polygenic, as well as skeletal dysplasias, and rarer bone disorders. The fourth section highlights the central role of the parathyroids in calcium and skeletal homeostasis by reviewing the molecular genetics of: hyperparathyroidism, hypoparathyrodism, endocrine neoplasias, and disorders of the PTH and calcium-sensing receptors. The fifth section details molecular and cellular advances across associated renal disorders such as vitamin D and rickets. Identifies and analyzes the genetic basis of bone disorders in humans and demonstrates the utility of mouse models in furthering the knowledge of mechanisms and evaluation of treatments Demonstrates how the interactions between bone and joint biology, physiology, and genetics have greatly enhanced the understanding of normal bone function as well as the molecular pathogenesis of metabolic bone disorders Summarizes the clinical, genetic, molecular, animal model, molecular pathology, diagnostic, counseling, and treatment aspects of each disorder

Principles of Bone Biology

Principles of Bone Biology Book
Author : John P. Bilezikian,Lawrence G. Raisz,T. John Martin
Publisher : Academic Press
Release : 2008-09-29
ISBN : 9780080568751
Language : En, Es, Fr & De

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Book Description :

Principles of Bone Biology provides the most comprehensive, authoritative reference on the study of bone biology and related diseases. It is the essential resource for anyone involved in the study of bone biology. Bone research in recent years has generated enormous attention, mainly because of the broad public health implications of osteoporosis and related bone disorders. Provides a "one-stop" shop. There is no need to search through many research journals or books to glean the information one wants...it is all in one source written by the experts in the field The essential resource for anyone involved in the study of bones and bone diseases Takes the reader from the basic elements of fundamental research to the most sophisticated concepts in therapeutics Readers can easily search and locate information quickly as it will be online with this new edition

Pediatric Bone

Pediatric Bone Book
Author : Francis H. Glorieux,John M. Pettifor,Harald Jüppner
Publisher : Academic Press
Release : 2012
ISBN : 0123820405
Language : En, Es, Fr & De

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Book Description :

Pediatric Bone is the first book to be published to deal exclusively with the biology and diseases of bone as they affect children. Rapid advances have been made in our understanding of the mechanisms and factors controlling the growth and development of bone, and these are discussed in detail in this book. Further, the various diseases of bone which are peculiar to children are highlighted and discussed in the light of our current knowledge with regard to the causation, clinical signs and treatment. The book is aimed to provide those clinicians interested in children's diseases and basic scientists with a comprehensive resource covering the various aspects of bone health and disease in children Key Features * Deals exclusively with bone development and diseases of children and each chapter written by an * Fully referenced providing an appendix of usually difficult to find information on the investigation of pediatric bone disease and reference values * Covers both the physiology of bone and mineral homeostasis in children and diseases in one book * Includes a CD-ROM of images

Principles of Bone Biology

Principles of Bone Biology Book
Author : John P. Bilezikian,T. John Martin,Thomas L. Clemens,Clifford Rosen
Publisher : Academic Press
Release : 2019-08-22
ISBN : 012814842X
Language : En, Es, Fr & De

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Book Description :

Preface from the first edition (1996): "The world of modern science is undergoing a number of spectacular events that are redefining our understanding of ourselves. As with any revolution, we should take stock of where we have been, where we are, and where we are going. Our special world of bone biology is participating in and taking advantage of the larger global revolution in modern science... we assembled experts from all over the world and asked them to focus on the current state of knowledge and the prospects for new knowledge in their area of expertise. To this end, Principles of Bone Biology was conceived." - John P. Bilezikian, Lawrence G. Raisz, Gideon A. Rodan Praise for the previous edition: "Students, teachers, and practitioners will benefit from reading it, and investigators will use it as a reference work; it will certainly be consulted frequently." --The New England Journal of Medicine For over two decades, "Big Gray" has been the go-to repository of knowledge in the disciplines related to bone and mineral metabolism. The fourth edition is a must-have for students new to the field; young investigators at the graduate or postgraduate level beginning their research careers; established scientists who need to keep up with the changing nature of the field, looking to enrich their own research programs, or who are changing their career direction; clinicians who want ready access to up-to-date relevant basic science. This new edition builds on the successful formula from previous editions, taking the reader from the basic elements of fundamental research to the most sophisticated concepts in therapeutics. Principles of Bone Biology, Fourth Edition provides the most comprehensive, authoritative reference on the study of bone biology and related diseases. Bone research continues to generate enormous attention, due to the broad public health implications of osteoporosis and related bone disorders. This classic, fully updated, two volume reference is designed for anyone involved in the study of bone biology. Provides a "one-stop" shopping paradise. Anything you want to find about bone biology is here and written by the world’s experts THE essential resource for anyone involved in the study of the skeleton and metabolic bone diseases Covers everything from the basic scientific concepts to the underlying principles of therapeutics and management Allows readers to easily search and locate information quickly in the online format Volumes include: Basic Principles; Molecular Mechanisms of Metabolic Bone Disease; Pharmacological Mechanisms of Therapeutics; Methods in Bone Research

Bone Disease of Organ Transplantation

Bone Disease of Organ Transplantation Book
Author : Juliet Compston,Elizabeth Shane
Publisher : Elsevier
Release : 2005-01-26
ISBN : 9780080490540
Language : En, Es, Fr & De

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Book Description :

Bone disease, particularly osteoporosis, has emerged as a common and serious complication of solid organ transplantation. In recent years there have been real advances in our understanding of the pathogenesis and pathophysiology of bone loss, however treatment studies have been relatively sparse and successful strategies to reduce skeletal morbidity after transplantation remain to be clearly established. Bone Disease of Organ Transplantation provides a unique resource for the many health professionals involved with transplantation of bone disease, both in terms of its scientific background and the management of the disease in clinical practice. Basic Transplantation and Bone Biology Pathogenesis of Transplantation Related Bone Disease Clinical Features of Transplantation Bone Disease Management

The Genetics of Osteoporosis and Metabolic Bone Disease

The Genetics of Osteoporosis and Metabolic Bone Disease Book
Author : Michael J. Econs
Publisher : Springer Science & Business Media
Release : 2000-05-12
ISBN : 1592590330
Language : En, Es, Fr & De

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Book Description :

The explosive growth in the field of molecular biology over the last two decades has started to make a great impact on clinical medicine. Genes have been cloned for diseases that were poorly understood only a decade ago. Additionally, investigators are increasingly aware that there are strong genetic components to complex disorders, such as osteoporosis, that are not classically thought of as genetic disorders. New insights into the pathogenesis of metabolic bone diseases have been obtained from investigations into the molecular biology of these diseases and new therapies will become available based on these new insights. In The Genefies of Osteoporosis and Metabolie Bane Disease, I have assembled an internationally renowned group of experts to write the various chapters. Each of the authors is an expert in his/her field who is currently performing research on the content of their chapter and have made important contributions to the understanding of the clinical fea tures and pathophysiology of metabolic bone disease and genetics. The first part of The Genefies of Osteoporosis and Metabolie Bane Disease addresses issues related to genetic contributions to the development of osteoporosis and the many factors that must be considered when searching for genesthat predispose to osteoporosis. The second sec tion addresses recent advances in the clinical and molecular biological aspects of inherited metabolic bone disorders. The last section reviews the latest techniques for finding genes that predispose to metabolic bone diseases.

ASBMR Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism

ASBMR Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism Book
Author : Anonim
Publisher : John Wiley & Sons
Release : 2009-12-22
ISBN : 0470623985
Language : En, Es, Fr & De

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Book Description :

EDITOR-IN-CHIEF: Clifford J. Rosen, M.D., Maine Medical Center Research Institute, Scarborough, Maine SENIOR ASSOCIATE EDITORS: Juliet E. Compston, M.D., FRCP, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom Jane B. Lian, Ph.D., University of Massachusetts Medical School, Worcester, Massachusetts This comprehensive yet concise handbook is an indispensable reference for the many clinicians who see patients with disorders of bone formation, metabolic bone diseases, or disorders of stone formation. It is also a crucial tool for researchers, students, and all other professionals working in the bone field. In a format designed for quick reference, it provides complete information on the symptoms, pathophysiology, diagnosis, and treatment of all common and rare bone and mineral disorders. New in this edition: detailed coverage of osteonecrosis of the jaw, more in-depth coverage of cancer and bone including new approaches to pathogenesis, diagnosis, and treatment; new approaches to anabolic therapy of osteoporosis; the latest research on Vitamin D; expanded coverage of international topics; more on the genetics of bone mass; and newer imaging techniques for the skeleton. In addition, this edition features a free, online-only appendix of medicines used to treat bone disorders and their availability around the world.

Encyclopedia of Bone Biology

Encyclopedia of Bone Biology Book
Author : Mone Zaidi
Publisher : Academic Press
Release : 2020-07-14
ISBN : 9780128140819
Language : En, Es, Fr & De

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Book Description :

Encyclopedia of Bone Biology covers hot topics from within the rapidly expanding field of bone biology and skeletal research, enabling a complete understanding of both bone physiology and its relation to other organs and pathophysiology. This encyclopedia will serve as a vital resource for those involved in bone research, research in other fields that cross link with bone, such as metabolism and immunology, and physicians who treat bone diseases. Each article provides a comprehensive overview of the selected topic to inform a broad spectrum of readers from advanced undergraduate students to research professionals. Chapters also explore the latest advances and hot topics that have emerged in recent years, including the Hematopoietic Niche and Nuclear Receptors. In the electronic edition, each chapter will include hyperlinked references and further readings as well as cross-references to related articles. Incorporates perspectives from experts working within the domains of biomedicine, including physiology, pathobiology, pharmacology, immunology, endocrinology, orthopedics and metabolism Provides an authoritative introduction for non-specialists and readers from undergraduate level upwards, as well as up-to-date foundational content for those familiar with the field Includes multimedia features, cross-references and color images/videos

Basic and Applied Bone Biology

Basic and Applied Bone Biology Book
Author : David B. Burr,Matthew R. Allen
Publisher : Academic Press
Release : 2019-03-15
ISBN : 9780128132593
Language : En, Es, Fr & De

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Book Description :

Basic and Applied Bone Biology, Second Edition provides an overview of skeletal biology from the molecular level to the organ level, including cellular control, interaction and response; adaptive responses to various external stimuli; the interaction of the skeletal system with other metabolic processes in the body, and the effect of various disease processes on the skeleton. The book includes chapters that address how the skeleton can be evaluated through the use of various imaging technologies, biomechanical testing, histomorphometric analysis, and the use of genetically-modified animal models. It delves into the important details of the chapter topics, ensuring a solid understanding of the basics of bone biology. Bone biology is an established area of research and education, but remarkably there is no accessible graduate level appropriate text or reference focused specifically on the biology of the skeletal system. Larger reference books exist, but these are too detailed and too expensive for new researchers and clinicians to the field of bone biology. Smaller references attempt to act as textbooks, but they are extremely broad in scope and treat many subjects superficially. Basic and Applied Bone Biology, Second Edition fills this gap. If you are a bone biology researcher who is also training undergraduate and graduate students in the lab, you will use this book constantly - to orient new students in the basics of the field and as a background reference for many of the technical aspects of qualification in bone biology (eg., mechanics, histomorphometry, genetic modification, biochemistry, etc). Presents an in-depth overview of skeletal biology from the molecular to the organ level Offers "refresher" level content for clinicians or researchers outside their areas of expertise Includes updated and complete references Incorporates expanded study questions at the end of each chapter for further exploration of the topic Covers topics relevant to a modern course in skeletal biology

Bone Dysplasias

Bone Dysplasias Book
Author : Jürgen W. Spranger,Paula W. Brill,Christine Hall,Gen Nishimura,Andrea Superti-Furga,Sheila Unger
Publisher : Oxford University Press
Release : 2018-10-25
ISBN : 0190914521
Language : En, Es, Fr & De

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Book Description :

The definitive guide to genetic bone disorders, now revised and expanded with glossy photographs and radiographs "Brilliantly written and produced and deserves to be on the shelves of all pediatric radiologists. It should also be available to geneticists, counselors, and pediatricians." --Radiology This updated and expanded fourth edition of Bone Dysplasias presents age-related radiographs, photographs and clinical guidelines for more than 250 rare constitutional skeletal diseases. Focusing on diagnostically essential imaging and clinical features, each chapter is supplemented with prognostic and therapeutic information, a guide to differential diagnoses, and a short list of the most relevant publications. Organized in accordance with the most recent International Nosology and Classification of Genetic Skeletal Disorders, this new Bone Dysplasias distills the insights of a small, world-class author team on diagnosis and clinical approaches to this most difficult class of disorders.

Osteoporosis in Men

Osteoporosis in Men Book
Author : Eric S. Orwoll,John P. Bilezikian,Dirk Vanderschueren
Publisher : Academic Press
Release : 2009-11-30
ISBN : 9780080923468
Language : En, Es, Fr & De

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Book Description :

Since the publication of the first edition, the U.S. Surgeon General released the first-ever report on bone health and osteoporosis in October 2004. This report focuses even more attention on the devastating impact osteoporosis has on millions of lives. According to the National Osteoporosis Foundation, 2 million American men have osteoporosis, and another 12 million are at risk for this disease. Yet despite the large number of men affected, the lack of awareness by doctors and their patients puts men at a higher risk that the condition may go undiagnosed and untreated. It is estimated that one-fifth to one-third of all hip fractures occur in men. This second edition brings on board John Bilezikian and Dirk Vanderschueren as editors with Eric Orwoll. The table of contents is more than doubling with 58 planned chapters. The format is larger – 8.5 x 11. This edition of Osteoporosis in Men brings together even more eminent investigators and clinicians to interpret developments in this growing field, and describe state-of-the-art research as well as practical approaches to diagnosis, prevention and therapy. Brings together more eminent investigators and clinicians to interpret developments in this growing field. Describes state-of-the-art research as well as practical approaches to diagnosis, prevention and therapy. There is no book on the market that covers osteoporosis in men as comprehensively as this book.

Bone Health and Osteoporosis

Bone Health and Osteoporosis Book
Author : United States Public Health Service,Ge Surgeon General of the United States
Publisher : International Law & Taxation Pub
Release : 2004-12-01
ISBN : 9781410219275
Language : En, Es, Fr & De

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Book Description :

This first-ever Surgeon General's Report on bone health and osteoporosis illustrates the large burden that bone disease places on our Nation and its citizens. Like other chronic diseases that disproportionately affect the elderly, the prevalence of bone disease and fractures is projected to increase markedly as the population ages. If these predictions come true, bone disease and fractures will have a tremendous negative impact on the future well-being of Americans. But as this report makes clear, they need not come true: by working together we can change the picture of aging in America. Osteoporosis, fractures, and other chronic diseases no longer should be thought of as an inevitable part of growing old. By focusing on prevention and lifestyle changes, including physical activity and nutrition, as well as early diagnosis and appropriate treatment, Americans can avoid much of the damaging impact of bone disease and other chronic diseases. This Surgeon General's Report brings together for the first time the scientific evidence related to the prevention, assessment, diagnosis, and treatment of bone disease. More importantly, it provides a framework for moving forward. The report will be another effective tool in educating Americans about how they can promote bone health throughout their lives. This first-ever Surgeon General's Report on bone health and osteoporosis provides much needed information on bone health, an often overlooked aspect of physical health. This report follows in the tradition of previous Surgeon Generals' reports by identifying the relevant scientific data, rigorously evaluating and summarizing the evidence, and determining conclusions.

Bones and Cartilage

Bones and Cartilage Book
Author : Brian K. Hall
Publisher : Academic Press
Release : 2014-12-23
ISBN : 0124166857
Language : En, Es, Fr & De

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Book Description :

Bones and Cartilage provides the most in-depth review and synthesis assembled on the topic, across all vertebrates. It examines the function, development and evolution of bone and cartilage as tissues, organs and skeletal systems. It describes how bone and cartilage develop in embryos and are maintained in adults, how bone is repaired when we break a leg, or regenerates when a newt grows a new limb, or a lizard a new tail. The second edition of Bones and Cartilage includes the most recent knowledge of molecular, cellular, developmental and evolutionary processes, which are integrated to outline a unified discipline of developmental and evolutionary skeletal biology. Additionally, coverage includes how the molecular and cellular aspects of bones and cartilage differ in different skeletal systems and across species, along with the latest studies and hypotheses of relationships between skeletal cells and the most recent information on coupling between osteocytes and osteoclasts All chapters have been revised and updated to include the latest research. Offers complete coverage of every aspect of bone and cartilage, with updated references and extensive illustrations Integrates development and evolution of the skeleton, as well a synthesis of differentiation, growth and patterning Treats all levels from molecular to clinical, embryos to evolution, and covers all vertebrates as well as invertebrate cartilages Includes new chapters on evolutionary skeletal biology that highlight normal variation and variability, and variation outside the norm (neomorphs, atavisms) Updates hypotheses on the origination of cartilage using new phylogenetic, cellular and genetic data Covers stem cells in embryos and adults, including mesenchymal stem cells and their use in genetic engineering of cartilage, and the concept of the stem cell niche

Cellular and Molecular Biology of Bone

Cellular and Molecular Biology of Bone Book
Author : Masaki Noda
Publisher : Academic Press
Release : 1993-09-13
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Cellular and Molecular Biology of Bone covers the differentiation of these cells, the regulation of their growth and metabolism, and their death and resorption.

Bone Pathology

Bone Pathology Book
Author : Jasvir S. Khurana
Publisher : Springer Science & Business Media
Release : 2009-12-02
ISBN : 1597453471
Language : En, Es, Fr & De

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Book Description :

Bone Pathology is the second edition of the book, A Compendium of Skeletal Pathology that published 10 years ago. Similar to the prior edition, this book complements standard pathology texts and blends new but relatively established information on the molecular biology of the bone. Serving as a bench-side companion to the surgical pathologist, this new edition reflects new advances in our understanding of the molecular biology of bone. New chapters on soft-tissue sarcomas and soft-tissue tumors have been added as well as several additional chapters such as Soft-tissue pathology and Biomechanics. The volume is written by experts who are established in the field of musculoskeletal diseases. Bone Pathology is a combined effort from authors of different specialties including surgeons, pathologists, radiologists and basic scientists all of whom have in common an interest in bone diseases. It will be of great value to surgical pathology residents as well as practicing pathologists, skeletal radiologists, orthopedic surgeons and medical students.

Calcium and Bone Disorders in Children and Adolescents

Calcium and Bone Disorders in Children and Adolescents Book
Author : J. Allgrove,N.J. Shaw
Publisher : Karger Medical and Scientific Publishers
Release : 2015-06-11
ISBN : 3318054674
Language : En, Es, Fr & De

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Book Description :

There has been a rapid expansion of knowledge in the field of paediatric calcium and bone disorders over the past twenty years. Advances have been made in the underlying genetic basis for many conditions in conjunction with progress in bone density and geometry imaging and the development of new treatment options. The 2nd revised edition of ‘Calcium and Bone Disorders in Children and Adolescents’ presents up-to-date information on many aspects included in the 1st edition such as the physiology, pathology, diagnosis and management of numerous conditions including a chapter of case histories illustrating clinical aspects. New chapters on skeletal dysplasias, the genetics of osteoporosis, radiological imaging of bone and a practical approach to a child with recurrent fractures are included. Providing a comprehensive update, this book is a useful clinical resource for paediatricians and specialists in endocrinology, metabolic bone disease, nephrology, rheumatology, radiology, orthopaedics and clinical genetics who may be faced with a child with a calcium and/or bone disorder.

The Bioarchaeology of Metabolic Bone Disease

The Bioarchaeology of Metabolic Bone Disease Book
Author : Megan Brickley,Rachel Ives
Publisher : Academic Press
Release : 2008-06-18
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

'The Bioarchaeology of Metabolic Bone Disease' provides a comprehensive source of information on this important group of diseases. It is a guide for those engaged in either basic recording or in-depth research on human remains from archaeological sites.

Advances in Pathobiology and Management of Paget s Disease of Bone

Advances in Pathobiology and Management of Paget   s Disease of Bone Book
Author : Sakamuri V. Reddy
Publisher : Academic Press
Release : 2016-04-28
ISBN : 012809690X
Language : En, Es, Fr & De

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Book Description :

Advances in Pathobiology and Management of Paget’s Disease of Bone presents an essential collection of up-to-date knowledge about the pathophysiology, genetics, and treatment of Paget’s disease. It covers the comprehensive information related to clinical perspectives, epidemiology, genetics, environmental factors such as viral etiology, molecular abnormalities, complications such as osteosarcoma, and current and future treatment for Paget’s disease. This book serves as a useful volume for basic scientists, graduate students, and practicing clinicians in understanding the pathobiology, etiology, and treatment of this disease. Discusses the current research of the nature of Paget’s disease and its response to the latest treatments which are seminal in the management of this disease Helps users quickly assess the very latest details on the diverse scientific and clinical aspects of Paget’s disease, as opposed to searching through multiple journal articles in the literature Presents work from featured leaders in Paget’s disease around the globe Serves as a useful volume for basic scientists, graduate students, and practicing clinicians in understanding the pathobiology, etiology, and treatment of this disease

Current Topics in Bone Biology

Current Topics in Bone Biology Book
Author : Hong-wen Deng,Yao-zhong Liu,Chun-Yuan Guo
Publisher : World Scientific
Release : 2005
ISBN : 9812562095
Language : En, Es, Fr & De

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Book Description :

This book covers a wide spectrum of areas related to basic bone research. While bone remodeling, bone development, and osteoclast biology constitute the main contents, topics important to the understanding of bone metabolism and treatment of bone-related diseases are also intensively reviewed. Three chapters are dedicated to the classic topic of bone mechanics, which include a brief overview of the mechanostat hypothesis, a more detailed review on mechanotransduction and bone adaptation, and a chapter illustrating the basic principles of bone mechanical testing. New emerging fields such as skeletal stem cells, bone tissue engineering, phytoestrogens applications, and bone genetics study using mouse models, are also covered in detail. The book closes with a special chapter dedicated to state-of-the-art advances in bone biology research.

Osteogenesis Imperfecta

Osteogenesis Imperfecta Book
Author : Peter H. Byers,Paul Sponseller
Publisher : Academic Press
Release : 2013-08-06
ISBN : 0123977894
Language : En, Es, Fr & De

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Book Description :

Osteogenesis Imperfecta is the first translational reference professionals can turn to for a source of comprehensive information on this disorder. Although several reviews of the field have been published in various journals, there is no other single source for a compendium of current information. Separate chapters discuss each of the several clinical features of OI. Ethical issues related to OI are discussed, as is the importance of nutrition in managing the OI child and the OI adult. The role of physical medicine and rehabilitation for OI patients is also presented, along with the current status of OI medical treatment and the prospects for genetic engineering in the future. The text also provides the orthopedic surgeon with an advanced discussion of surgical techniques applicable to OI. Incorporates chapters and information on the ethical issues related to osteogenesis imperfecta (OI) as will the importance of nutrition in managing the OI child and the OI adult Offers new insights into the underlying mechanisms of collagen biochemistry as related to OI as well as a presentation of intracellular collagen processing and the expanded role of protein chaperones in OI Discusses the role of physical medicine and rehabilitation for OI patients and the current status of OI medical treatment as well as prospects for genetic engineering in the future Provides a unique overview for the orthopedic surgeon with an advanced discussion of surgical techniques applicable to OI