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Genes Environment And Alzheimers Disease

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Genes Environment and Alzheimer s Disease

Genes  Environment and Alzheimer s Disease Book
Author : Orly Lazarov,Giuseppina Tesco
Publisher : Academic Press
Release : 2016-02-25
ISBN : 0128028858
Language : En, Es, Fr & De

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Book Description :

Genes, Environment and Alzheimer's Disease discusses the role that activities such as exercise can play in cardiovascular health, while also highlighting the fact that the last 10 years have brought great discoveries in the strong environmental component of brain disorders, neurodegeneration, and cognitive decline. It is now clear that brain insult is an environmental risk factor for AD, while on the other hand, lifestyle components such as exercise and level of education may play a protective role, delaying the onset and/or severity of the disease. Evidence from experiments in rodent models of Alzheimer’s disease contributes major insight into the molecular mechanisms by which the environment plays its role in AD. Additionally, there are diseases related to lifestyle that may lead to AD. This volume reviews new discoveries related to all these factors, serving as a translational tool for clinicians and researchers interested in genetic and environmental risk factors for the disease. Provides the first volume to link genetic and environmental risk factors for Alzheimer’s disease and dementia Aids researchers and clinicians in understanding the basic mechanisms of Alzheimer’s disease and cognitive decline Brings the basic science and clinical perspectives together in a single volume, facilitating translational possibilities Includes a range of molecular to behavioral components assembled into a single volume that creates an excellent resource for basic and clinical neuroscientists

Genes Environment and Alzheimer s Disease

Genes  Environment and Alzheimer s Disease Book
Author : Orly Lazarov
Publisher : Academic Press
Release : 2016-03-01
ISBN : 9780128028513
Language : En, Es, Fr & De

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Book Description :

Genes, Environment and Alzheimer's Disease discusses the role that activities such as exercise can play in cardiovascular health, while also highlighting the fact that the last 10 years have brought great discoveries in the strong environmental component of brain disorders, neurodegeneration, and cognitive decline. It is now clear that brain insult is an environmental risk factor for AD, while on the other hand, lifestyle components such as exercise and level of education may play a protective role, delaying the onset and/or severity of the disease. Evidence from experiments in rodent models of Alzheimer's disease contributes major insight into the molecular mechanisms by which the environment plays its role in AD. Additionally, there are diseases related to lifestyle that may lead to AD. This volume reviews new discoveries related to all these factors, serving as a translational tool for clinicians and researchers interested in genetic and environmental risk factors for the disease. Provides the first volume to link genetic and environmental risk factors for Alzheimer's disease and dementia Aids researchers and clinicians in understanding the basic mechanisms of Alzheimer's disease and cognitive decline Brings the basic science and clinical perspectives together in a single volume, facilitating translational possibilities Includes a range of molecular to behavioral components assembled into a single volume that creates an excellent resource for basic and clinical neuroscientists

Behavior Genetics of Cognition Across the Lifespan

Behavior Genetics of Cognition Across the Lifespan Book
Author : Deborah Finkel,Chandra A. Reynolds
Publisher : Springer Science & Business Media
Release : 2013-07-09
ISBN : 1461474477
Language : En, Es, Fr & De

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Book Description :

Along with psychopathology, cognition has been one of the primary phenotypic focal points of the field of behavior genetics since its inception. Francis Galton’s 1874 examination of eminent families in Britain was among the earliest attempts to investigate whether cognitive achievements run in families. This volume presents current methodologies for understanding cognitive abilities that move beyond the outdated nature vs. nurture paradigm. Recent advances in both collection and statistical modeling of twin data, particularly longitudinal twin data, make this an especially advantageous moment to produce a work that presents a collection of the groundbreaking research on cognitive abilities across the lifespan. This volume presents an overview of the current state of quantitative and molecular genetic investigations into the many facets of cognitive performance and functioning across the lifespan.​

Challenging Genetic Determinism

Challenging Genetic Determinism Book
Author : Royal Society of Canada. Symposium
Publisher : McGill-Queen's Press - MQUP
Release : 2011
ISBN : 0773537805
Language : En, Es, Fr & De

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Book Description :

Compelling essays on understanding the interplay of genes in society.

Cognitive Enhancement

Cognitive Enhancement Book
Author : Shira Knafo,César Venero
Publisher : Academic Press
Release : 2014-12-20
ISBN : 0124171257
Language : En, Es, Fr & De

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Book Description :

Cognitive Enhancement: Pharmacologic, Environmental and Genetic Factors addresses the gap that exists in research on the topic, gathering multidisciplinary knowledge and tools that help the reader understand the basics of cognitive enhancement. It also provides assistance in designing procedures and pharmacological approaches to further the use of novel cognitive enhancers, a field that offers potential benefit to a variety of populations, including those with neurologic and psychiatric disorders, mild aging-related cognitive impairment, and those who want to improve intellectual performance. The text builds on our knowledge of the molecular/cellular basis of cognitive function, offering the technological developments that may soon enhance cognition. Separate sections cover enhancement drugs, environmental conditions, and genetic factors in terms of both human and animal studies, including both healthy/young and aging/diseased individuals. Provides a multidisciplinary knowledge, enabling a further understanding of cognitive enhancement Offers coverage of the pharmacologic, environmental, and genetic factors relevant to the topic Discusses cognitive enhancement from the perspective of both healthy and diseased or aging populations Topics are discussed in terms of both human and animal studies

Human Genome Epidemiology

Human Genome Epidemiology Book
Author : Muin J. Khoury,Julian Little,Wylie Burke
Publisher : Oxford University Press
Release : 2004
ISBN : 0195146743
Language : En, Es, Fr & De

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Book Description :

This book describes the important role that epidemiologic methods play in the continuum from gene discovery to the development and application of genetic tests. It proceeds systematically from the fundamentals of genome technology and gene discovery, to epidemiologic approaches to gene characterization in the population, to the evaluation of genetic tests and their use in health services.

Alzheimer s Disease

Alzheimer s Disease Book
Author : Celestina Akbar
Publisher : Xlibris Corporation
Release : 2008
ISBN : 9781425797553
Language : En, Es, Fr & De

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Book Description :

This book has highlighted significant issues and needs of people afflicted with Alzheimer's disease and the understanding of the occurrence of AD. Many studies, services and programs were reviewed concerning the diagnostic work up of patients with the Alzheimer's disease. Hopefully, these and other studies will help future researchers to disentangle the genetic and environmental factors associated with AD.

Apolipoprotein E and Alzheimer s Disease

Apolipoprotein E and Alzheimer   s Disease Book
Author : A.D. Roses,K.H. Weisgraber,Y. Christen
Publisher : Springer Science & Business Media
Release : 2012-12-06
ISBN : 3642801099
Language : En, Es, Fr & De

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Book Description :

There is now considerable genetic evidence that the type 4 allele of the apolipoprotein E gene is a major susceptibility factor associated with late-onset Alzheimer's disease, the common form of the disease defined as starting after sixty years of age. The role of apolipoprotein E in normal brain metabolism and in the pathogenesis of Alzheimer's disease are new and exciting avenues of research. This book, written by the most outstanding scientists in this new filed, is the first presentation of results concerning the implications of apolipoprotein E on the genetics, cell biology, neuropathology, biochemistry, and therapeutic management of Alzheimer's disease.

Protein Aggregation and Fibrillogenesis in Cerebral and Systemic Amyloid Disease

Protein Aggregation and Fibrillogenesis in Cerebral and Systemic Amyloid Disease Book
Author : J. Robin Harris
Publisher : Springer Science & Business Media
Release : 2012-12-09
ISBN : 9400754167
Language : En, Es, Fr & De

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Book Description :

This volume of the Subcellular Biochemistry series is the result of the long-standing research interest of the editor in the molecular mechanism underlying Alzheimer’s disease and other amyloid diseases, indicated also by the earlier book in the series (Volume 38), devoted to Alzheimer’s disease. The broad coverage within the present amyloidogenesis book represents an attempt to collate current knowledge relating to the proteins and peptides involved in most of the known amyloid diseases, together with some amyloid/fibril-forming proteins and peptides that are not involved in diseases. Thus, the range of topics included is comprehensive and furthermore it was thought appropriate to include both basic science and clinical presentation of the subjects under discussion.

Gene Environment Transactions in Developmental Psychopathology

Gene Environment Transactions in Developmental Psychopathology Book
Author : Patrick H. Tolan,Bennett L. Leventhal
Publisher : Springer
Release : 2017-04-29
ISBN : 3319492276
Language : En, Es, Fr & De

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Book Description :

This book examines the current research in gene-environment transactions (GEX) and its potential use in developing interventions and applications tailored to individual genetic makeups. Key concepts underlying GEX studies in this area are defined, identifying fundamental challenges in devising informed research questions and conducting valid and useful experiments. Chapters analyze GEX models inspired by the present day genome-based frameworks, particularly in terms of advances in identifying and understanding complex environmental factors, using examples from common psychological conditions, such as antisocial behavior, chronic physical aggression, and chronic internalizing disorder. In addition, the book presents new and potential applications of the framework in the contexts of prevention science and intervention research. Topics featured in this book include: Epigenetics and the biology of gene x environment interactions. Gene by environment interactions and its potential use for intervention strategies in anxiety disorders. The challenges and potential for research on gene-environment interactions within autism spectrum disorder. Using genetically informed prevention trials to test gene x environment hypothese. Challenges for intervention research within the GEX framework. Gene-Environment Transactions in Developmental Psychopathology is a must-have resource for researchers/professors, clinicians, and related professionals as well as graduate students in developmental psychology, psychiatry, human genetics, and related disciplines.

The Etiology of Mental Disorders

The Etiology of Mental Disorders Book
Author : Ladislav Hosák,Mohammad Malekirad,Klára Látalová
Publisher : Charles University in Prague, Karolinum Press
Release : 2022-06-01
ISBN : 8024651475
Language : En, Es, Fr & De

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Book Description :

The textbook consists of three sections. The first offers a general overview of factors important to the etiology of mental disorders, particularly the genetic, epigenetic, environmental, and microbiomatic elements. The next part examines over two dozen significant mental disorders and details specific factors in their etiology. Finally, suggestions are made for further research in and development of the field. While primarily intended for medical students studying in English, the textbook’s clear and straightforward presentation should make it useful to specialists in the fields of psychiatry and neuroscience, as well.

Translational Research in Traumatic Brain Injury

Translational Research in Traumatic Brain Injury Book
Author : Daniel Laskowitz,Gerald Grant
Publisher : CRC Press
Release : 2015-12-01
ISBN : 1498766579
Language : En, Es, Fr & De

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Book Description :

Traumatic brain injury (TBI) remains a significant source of death and permanent disability, contributing to nearly one-third of all injury related deaths in the United States and exacting a profound personal and economic toll. Despite the increased resources that have recently been brought to bear to improve our understanding of TBI, the development of new diagnostic and therapeutic approaches has been disappointingly slow. Translational Research in Traumatic Brain Injury attempts to integrate expertise from across specialties to address knowledge gaps in the field of TBI. Its chapters cover a wide scope of TBI research in five broad areas: Epidemiology Pathophysiology Diagnosis Current treatment strategies and sequelae Future therapies Specific topics discussed include the societal impact of TBI in both the civilian and military populations, neurobiology and molecular mechanisms of axonal and neuronal injury, biomarkers of traumatic brain injury and their relationship to pathology, neuroplasticity after TBI, neuroprotective and neurorestorative therapy, advanced neuroimaging of mild TBI, neurocognitive and psychiatric symptoms following mild TBI, sports-related TBI, epilepsy and PTSD following TBI, and more. The book integrates the perspectives of experts across disciplines to assist in the translation of new ideas to clinical practice and ultimately to improve the care of the brain injured patient.

Genetic Disorders Sourcebook

Genetic Disorders Sourcebook Book
Author : Keith Jones
Publisher : Omnigraphics
Release : 2016-07-01
ISBN : 9780780815223
Language : En, Es, Fr & De

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Book Description :

"Provides basic consumer health information about disorders caused by gene and chromosome abnormalities and those with genetic and environmental components, along with facts about genetic testing and treatment research, and guidance for parents of children with special needs. Includes index, glossary of related terms, and other resources"--

Genetic Disorders

Genetic Disorders Book
Author : Robin Santos Doak
Publisher : Benchmark Education Company
Release : 2010
ISBN : 1450908020
Language : En, Es, Fr & De

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Book Description :

Readers learn about different types of genetic disorders. They learn how some are passed down from parent to child while others happen when the environment affects genes.

Environmental Neuroscience

Environmental Neuroscience Book
Author : National Academies of Sciences, Engineering, and Medicine,Division on Earth and Life Studies,Health and Medicine Division,Board on Environmental Studies and Toxicology,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders
Publisher : National Academies Press
Release : 2021-01-22
ISBN : 0309683092
Language : En, Es, Fr & De

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Book Description :

Humans are potentially exposed to more than 80,000 toxic chemicals in the environment, yet their impacts on brain health and disease are not well understood. The sheer number of these chemicals has overwhelmed the ability to determine their individual toxicity, much less potential interactive effects. Early life exposures to chemicals can have permanent consequences for neurodevelopment and for neurodegeneration in later life. Toxic effects resulting from chemical exposure can interact with other risk factors such as prenatal stress, and persistence of some chemicals in the brain over time may result in cumulative toxicity. Because neurodevelopmental and neurodegenerative disorders - such as attention-deficit hyperactivity disorder and Parkinson's disease - cannot be fully explained by genetic risk factors alone, understanding the role of individual environmental chemical exposures is critical. On June 25, 2020, the National Academies of Sciences, Engineering, and Medicine's Forum on Neuroscience and Nervous System Disorders hosted a workshop to lay the foundation for future advances in environmental neuroscience. The workshop was designed to explore new opportunities to bridge the gap between what is known about the genetic contribution to brain disorders and what is known, and not known, about the contribution of environmental influences, as well as to discuss what is known about how genetic and environmental factors interact. This publication summarizes the presentation and discussion of the workshop.

Neurology in Clinical Practice

Neurology in Clinical Practice Book
Author : Walter George Bradley
Publisher : Unknown
Release : 2004
ISBN : 9780750674690
Language : En, Es, Fr & De

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Book Description :

New edition, completely rewritten, with new chapters on endovascular surgery and mitochrondrial and ion channel disorders.

Alzheimer s Disease

Alzheimer s Disease Book
Author : Xudong Huang
Publisher : Unknown
Release : 2020-12-31
ISBN : 9780645001709
Language : En, Es, Fr & De

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Book Description :

Download Alzheimer s Disease book written by Xudong Huang, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Genetic Analysis of Complex Disease

Genetic Analysis of Complex Disease Book
Author : Jonathan L. Haines,Margaret A. Pericak-Vance
Publisher : John Wiley & Sons
Release : 2007-02-26
ISBN : 0471781134
Language : En, Es, Fr & De

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Book Description :

Second Edition features the latest tools for uncovering thegenetic basis of human disease The Second Edition of this landmark publication bringstogether a team of leading experts in the field to thoroughlyupdate the publication. Readers will discover the tremendousadvances made in human genetics in the seven years that haveelapsed since the First Edition. Once again, the editorshave assembled a comprehensive introduction to the strategies,designs, and methods of analysis for the discovery of genes incommon and genetically complex traits. The growing social, legal,and ethical issues surrounding the field are thoroughly examined aswell. Rather than focusing on technical details or particularmethodologies, the editors take a broader approach that emphasizesconcepts and experimental design. Readers familiar with theFirst Edition will find new and cutting-edge materialincorporated into the text: Updated presentations of bioinformatics, multiple comparisons,sample size requirements, parametric linkage analysis, case-controland family-based approaches, and genomic screening New methods for analysis of gene-gene and gene-environmentinteractions A completely rewritten and updated chapter on determininggenetic components of disease New chapters covering molecular genomic approaches such asmicroarray and SAGE analyses using single nucleotide polymorphism(SNP) and cDNA expression data, as well as quantitative trait loci(QTL) mapping The editors, two of the world's leading genetic epidemiologists,have ensured that each chapter adheres to a consistent and highstandard. Each one includes all-new discussion questions andpractical examples. Chapter summaries highlight key points, and alist of references for each chapter opens the door to furtherinvestigation of specific topics. Molecular biologists, human geneticists, geneticepidemiologists, and clinical and pharmaceutical researchers willfind the Second Edition a helpful guide to understanding thegenetic basis of human disease, with its new tools for detectingrisk factors and discovering treatment strategies.

Alzheimer s Disease A Century of Scientific and Clinical Research

Alzheimer s Disease  A Century of Scientific and Clinical Research Book
Author : G. Perry,J. Avila,J. Kinoshita
Publisher : IOS Press
Release : 2006-06-26
ISBN : 1607501759
Language : En, Es, Fr & De

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Book Description :

This publication is a landmark work commemorating the centennial of Alois Alzheimer's discovery of what would be known as Alzheimer's disease (AD). The centennial of Alois Alzheimer’s original description of the disease that would come to bear his name offers a vantage point from which to commemorate the seminal discoveries in the field. It traces how the true importance of AD as the major cause of late life dementia ultimately came to light and narrates the evolution of the concepts related to AD throughout the years and its recognition as a major public health problem, with an estimated 30-40 million people affected by AD today. To identify the breakthroughs, the editors have used citation analysis, landmark papers identified by current researchers, and drew upon their own experience and insights. This process took into account the perspectives of individuals who recall the impact of findings at the time they were made, as well as of scientists today who have the advantage of hindsight in weighing the lasting influence of these findings. Because modern AD research was triggered by the seminal work of Tomlinson, Blessed, and Roth some four decades ago, it is particularly fortunate that the vast majority of these milestone authors are still with us.

Alzheimer s Disease

Alzheimer s Disease Book
Author : Inga Zerr
Publisher : BoD – Books on Demand
Release : 2015-07-01
ISBN : 9535121375
Language : En, Es, Fr & De

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Book Description :

There is a wide scope of clinical phenomenology in Alzheimers disease, regarding the age of onset, presenting features, rate of progression and appearance of other clinical manifestation. Although clinical appearance and neuropathological hallmarks have been defining AD since its first description, major factors which trigger pathology are still unknown. The role of comorbidity is discussed controversially. Important environmental risk factors in AD development are continuous stress, low education and cardiovascular risk factors such as alcohol intake, smoking, hypertension. The role of lipids and cholesterol has been recognized, but the relevant pathogenetic steps are still to be identified. There is an urgent need to understand molecular disease pathogenesis in order to develop early therapeutic targets for the disease.