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Gene Therapy

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Gene Therapy

Gene Therapy Book
Author : United States. Congress. Senate. Committee on Health, Education, Labor, and Pensions. Subcommittee on Public Health
Publisher : Unknown
Release : 2000
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Gene Therapy book written by United States. Congress. Senate. Committee on Health, Education, Labor, and Pensions. Subcommittee on Public Health, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Gene Therapy

Gene Therapy Book
Author : United States,United States. Congress. House. Committee on Science, Space, and Technology
Publisher : Unknown
Release : 1995
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Gene Therapy book written by United States,United States. Congress. House. Committee on Science, Space, and Technology, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Gene Therapy

Gene Therapy Book
Author : Rex A. Hudson,United States. Congress. Senate. Committee on Health, Education, Labor, and Pensions. Subcommittee on Public Health
Publisher : Unknown
Release : 2000
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Gene Therapy book written by Rex A. Hudson,United States. Congress. Senate. Committee on Health, Education, Labor, and Pensions. Subcommittee on Public Health, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Human Gene Therapy

Human Gene Therapy Book
Author : United States. Congress. Office of Technology Assessment
Publisher : Unknown
Release : 1984
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Human Gene Therapy book written by United States. Congress. Office of Technology Assessment, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Human Gene Therapy

Human Gene Therapy Book
Author : Anonim
Publisher : Unknown
Release : 1987
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Human Gene Therapy book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Adeno associated Viral Vectors for Gene Therapy

Adeno associated Viral Vectors for Gene Therapy Book
Author : Kenneth I. Berns,Terence Robin Flotte
Publisher : Unknown
Release : 2005
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Adeno associated Viral Vectors for Gene Therapy book written by Kenneth I. Berns,Terence Robin Flotte, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Gene Therapy

Gene Therapy Book
Author : Evelyn B. Kelly
Publisher : Greenwood Publishing Group
Release : 2007
ISBN : 9780313337604
Language : En, Es, Fr & De

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Book Description :

Presents an introduction to gene therapy, discussing its scientific background, the types of disorders which it can potentially treat, the ethical, social, and religious issues surrounding its use, and the role of government regulation.

Gene Therapy

Gene Therapy Book
Author : Mauro Giacca
Publisher : Springer Science & Business Media
Release : 2010-11-01
ISBN : 9788847016439
Language : En, Es, Fr & De

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Book Description :

I entered the gene therapy field in the mid-1990s, being fascinated by the immense potential of genes as drugs for the treatment of human disease. Since then, I have experienced the ups and downs of this discipline, and tried to contribute with my work and that of my laboratory to the development of innovative approaches to the treatment of cardiovascular disorders. During these years, I have had several opp- tunities to speak on gene therapy at lectures and academic lessons, and have often noticed that the field is very attractive to scientists of all disciplines. However, as yet no comprehensive book on the subject has been published. Indeed, most books in the field are either a collection of gene transfer laboratory protocols or deal with the subject in a rather superficial manner. Hence the idea to write a gene therapy textbook that is broad and comprehensive, but at the same time provides sufficient molecular and clinical detail to be of interest to students, professors, and specialists in the various disciplines that contribute to gene therapy. I have tried to keep the language plain and, whenever possible, non-technical. Since the book is intended to be a textbook in the field of gene therapy in both the basic science and clinical areas, whenever technical descriptions are required, they are provided.

Non invasive Analysis of Reporter Gene Expression and Suicide Gene Therapy by Prostate targeted TSTA System

Non invasive Analysis of Reporter Gene Expression and Suicide Gene Therapy by Prostate targeted  TSTA  System Book
Author : Mai Huy Johnson
Publisher : Unknown
Release : 2003
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Non invasive Analysis of Reporter Gene Expression and Suicide Gene Therapy by Prostate targeted TSTA System book written by Mai Huy Johnson, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Induced Pluripotent Stem Cell iPSC based Gene Therapy of CSF2R c deficient Pulmonary Alveolar Proteinosis in a Murine Disease Model

Induced Pluripotent Stem Cell  iPSC  based Gene Therapy of CSF2R  c deficient Pulmonary Alveolar Proteinosis in a Murine Disease Model Book
Author : Adele Mucci
Publisher : Unknown
Release : 2016
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Induced Pluripotent Stem Cell iPSC based Gene Therapy of CSF2R c deficient Pulmonary Alveolar Proteinosis in a Murine Disease Model book written by Adele Mucci, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Gene Therapy

Gene Therapy Book
Author : Joseph Panno
Publisher : Infobase Publishing
Release : 2005
ISBN : 0816067341
Language : En, Es, Fr & De

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Book Description :

Many diseases are caused by a simple point mutation.

Safety and Early Efficacy Outcomes for Lentiviral Fibroblast Gene Therapy for Recessive Dystrophic Epidermolysis Bullosa

Safety and Early Efficacy Outcomes for Lentiviral Fibroblast Gene Therapy for Recessive Dystrophic Epidermolysis Bullosa Book
Author : Jemima E Mellerio
Publisher : Unknown
Release : 2017
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Recessive dystrophic epidermolysis bullosa (RDEB) is a severe form of skin fragility disorder due to mutations in COL7A1 encoding basement membrane type VII collagen (C7), the main constituent of anchoring fibrils (AFs) in skin. We developed a self-inactivating lentiviral platform encoding a codon-optimized COL7A1 cDNA under the control of a human phosphoglycerate kinase promoter for phase I evaluation. In this single-centre, open-label phase I trial, 4 adults with RDEB each received 3 intradermal injections (~1 u00d7 10^6 cells/cm of intact skin) of COL7A1-modified autologous fibroblasts and were followed up for 12 months. Theprimary outcome was safety, including autoimmune reactions against recombinant C7. Secondary outcomes included C7 expression, AF morphology, and presence of transgene in the injected skin. Gene-modified fibroblasts were well tolerated, without serious adverse reactions or autoimmune reactions against recombinant C7. Regarding efficacy, there was a significant (P

Stem Cell Biology and Gene Therapy

Stem Cell Biology and Gene Therapy Book
Author : Peter J. Quesenberry,Gary S. Stein,Bernard G. Forget,Sherman M. Weissman
Publisher : John Wiley & Sons
Release : 1998-09-10
ISBN : 9780471146568
Language : En, Es, Fr & De

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Book Description :

STEM CELL BIOLOGY AND GENE THERAPY Edited by Peter J. Quesenberry, Gary S. Stein, Bernard Forget, and Sherman Weissman Advances in molecular genetics and recombinant DNA technology have ushered in a new era in medical therapeutic research. New insights into the molecular basis of human disease and the role played by biological regulatory mechanisms have precipitated tremendous drug development efforts backed by intensive research into human gene therapy worldwide. Stem Cell Biology and Gene Therapy is the first book to thoroughly cover major advances in the field and their applications to novel molecular therapies. This self-contained volume integrates biological and clinical components of stem cell biology, examines some of the most difficult aspects of gene therapy, and provides a systematic review of advanced gene modification techniques. Twenty essays by leading researchers address some of the most compelling topics in contemporary medical research, including: * Fundamental regulatory mechanisms that operate in stem cells * Stem cells from a therapeutic perspective, including preparations of stem cells and their therapeutic potential as vehicles for gene therapy * Delivery systems for therapeutic genes, including an overview of the most promising vectors * Clinical applications for gene therapy, covering a broad range of diseases such as hemophilia, cancers, neurological disease, and more Complete with illustrations and real-world examples of a variety of disorders, Stem Cell Biology and Gene Therapy is essential for researchers in gene therapy and members of the biotechnology industry who are developing human molecular therapies for commercial use. It is also an important reference for molecular biologists, cell biologists, immunologists, molecular geneticists, hematologists, cancer researchers, biochemists, and anyone working in internal medicine.

The Development of Human Gene Therapy

The Development of Human Gene Therapy Book
Author : Professor at Center for Molecular Genetics Department of Paediatrics Theodore Friedmann,Theodore Friedmann
Publisher : CSHL Press
Release : 1999
ISBN : 9780879695286
Language : En, Es, Fr & De

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Book Description :

The idea of human gene therapy was accepted by the medical community and society at large long before believable clinical benefits began to emerge. In this book, some of the fields most distinguished contributors chronicle the evolution of this momentous direction for medicine, illustrating how imaginative concepts shaped the development of technologies and brought the daring new idea to its current position of imminent practical success. This is a book designed to endure as clinical advances accumulate, a clear-eyed work of reference that will anchor the further development of this revolution in therapy. It is an essential addition to libraries of clinical medicine, biotechnology, and public policy, and a resource that no laboratory investigator with an interest in the biology of gene transfer should be without.

A Guide to Human Gene Therapy

A Guide to Human Gene Therapy Book
Author : Roland W. Herzog,Sergei Zolotukhin
Publisher : World Scientific
Release : 2010
ISBN : 9814280917
Language : En, Es, Fr & De

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Book Description :

Ever since the birth of molecular biology, the tantalizing possibility of treating disease at its genetic roots has become increasingly feasible. Gene therapy - though still in its infancy - remains one of the hottest areas of research in medicine. Its approach utilizes a gene transfer vehicle ( vector) to deliver therapeutic DNA or RNA to cells of the body in order to rectify the defect that is causing the disease. Successful therapies have been reported in humans in recent years such as cures in boys with severe immune deficiencies. Moreover, gene therapy strategies are being adapted in numerous biomedical laboratories to obtain novel treatments for a variety of diseases and to study basic biological aspects of disease. Correction of disease in animal studies, is steadily gaining ground, highlighting the immense potential of gene therapy in the medical profession. This book will cover topics that are at the forefront of biomedical research such as RNA interference, viral and non-viral gene transfer systems, treatment of hematological diseases and disorders of the central nervous system.Leading experts on the respective vector or disease will contribute the individual chapters and explain cutting-edge technologies. It also gives a broad overview of the most important gene transfer vectors and most extensively studied target diseases. This comprehensive guide is therefore a must-read for anyone in the biotechnology, biomedical or medical industries seeking to further their knowledge in the area of human gene therapy.

Gene Therapy

Gene Therapy Book
Author : Kam Man Hui
Publisher : World Scientific Publishing Company Incorporated
Release : 1994
ISBN : 9789810216542
Language : En, Es, Fr & De

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Book Description :

With advances in our understanding of the molecular biology of human diseases and the development of efficient gene transfer techniques, the treatment of such diseases as cancer and infectious disease using gene therapy has progressed from a distant prospect to a distinct possibility in a very short time. The development of gene transfer methods which are suitable for different forms of therapy has been a major topic of research over the past several years. A common goal of this research has been to achieve the efficient delivery of genes into cells. The successful implementation of gene transfer as a cure for diseases, however, will continue to require the translation of preclinical studies in gene therapy into effective clinical protocols. This volume outlines the latest developments in cancer treatment using various gene delivery systems, which include cytokine gene transfer, the delivery of anti-ras DNA by retroviral vector and the injection of allogeneic HLA DNA via liposomes. Several of these molecular approaches have recently been approved by the US FDA as human clinical trial protocols in order to assess their therapeutic efficiency and safety for cancer treatment. Further developments in recombinant DNA technology within this field should ultimately lead to dramatic improvements in the practice of medicine.

Viral Vectors for Gene Therapy

Viral Vectors for Gene Therapy Book
Author : Curtis A. Machida
Publisher : Springer Science & Business Media
Release : 2003
ISBN : 1592593046
Language : En, Es, Fr & De

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Book Description :

Comprehensive and highly practical, Viral Vectors for Gene Therapy provides researchers with the basic tools needed to design targeted gene delivery vectors, and clinicians with an understanding of how to apply viral vectors to the treatment of genetic disorders. Offering detailed step-by-step instructions to ensure successful results, these experts detail the use of herpes viruses, adenoviruses, adeno-associated viruses, simple and complex retroviruses, including lentiviruses, and other virus systems for vector development and gene transfer. Additional chapters demonstrate the use of virus vectors in the brain and central nervous system.

Gene Therapy

Gene Therapy Book
Author : Gavin Brooks
Publisher : Unknown
Release : 2002
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Considers the genetic basis of disease and gene therapies, concentrating in detail on specific genetic illnesses, such as AIDS, cancer and cardiovascular diseases, and their treatment. This text should be of interest to pharmacists and to those involved in the biological or medical sciences.

Modelling and Gene Therapy for Pyruvate Kinase Deficiency

Modelling and Gene Therapy for Pyruvate Kinase Deficiency Book
Author : Sergio López Manzaneda
Publisher : Unknown
Release : 2018
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Pyruvate kinase deficiency (PKD) is the main cause of chronic non-spherocytichemolytic anemia. This disease is a monogenic recessive disorder that occurs due to mutations in PKLR gene. Although this gene codifies the expression of two isoforms of pyruvate kinase, expressed in liver and in red blood cell s, only the erythroid lineage is affected. Pyruvate kinase is the enzyme that catalyzes the last step of the glycolysis, a critical exergonic reaction for the energetic survival of erythrocytes. Due to its low prevalence (about 5:20,000), PKD is considered a rare disease. Severity of the disease is variable, ranging from mild cases, having hemoglobin levels around11 g/dL and requiring blood transfusions just during exacerbations, to values below 8.5 g/dLin the most severe cases, being transfusion-dependent and fatal in the worst cases. Most severe cases are transfusion-dependent even after splenectomy, the most agresive palliative treatment...

Textbook of Gene Therapy

Textbook of Gene Therapy Book
Author : Kewal K. Jain
Publisher : Seattle ; Toronto : Hogrefe & Huber
Release : 1998
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

During the past eight years following initial gene therapy experiments, more than 200 clinical protocols have been submitted worldwide and more than 2000 patients have been treated. Although a lot remains to be accomplished before gene therapy becomes a standard medical practice, enough information has accumulated to justify a textbook on the subject. Some of the procedures and products are expected to enter the marketplace and medical practice by the year 2000. The public is very much aware of the potential of gene therapy and the medical profession should prepare itself for the new developments by learning about the basics and applications of these techniques. Much of there-search has been conducted in the bio-pharmaceutical industry by gene therapy companies and the commercial opportunities for gene therapy are enormous. A large segment of the society thus has an interest in gene therapy. This book presents a unique critical review of the tremendous progress which has been made in this field. The textbook is an effort to bring a wide range of important developments together in an accessible format. This book is aimed at physicians, gene therapists, molecular biologists, nurse practitioners and students in these fields, as well as other healthcare professionals interested in developments in the field of gene therapy and its impact, both short- and long-term, on the practice of medicine. Industrial executives planning long-term strategies in gene therapy will find this handy textbook to be a comprehensive source of information on the subject and the companies involved in developing it. Prof. K. K. Jain is a neurosurgeon trained in Canada and the United States. He has heldacademic positions in major medical centers around the world. For the last decade, he has been a consultant to a number of major biopharmaceutical companies and now runs his own biotechnology company specializing in gene therapy research and documentation.