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Gene Therapy For Viral Infections

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Gene Therapy for Viral Infections

Gene Therapy for Viral Infections Book
Author : Patrick Arbuthnot
Publisher : Academic Press
Release : 2015-06-01
ISBN : 0124114520
Language : En, Es, Fr & De

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Book Description :

Gene Therapy for Viral Infections provides a comprehensive review of the broader field of nucleic acid and its use in treating viral infections. The text bridges the gap between basic science and important clinical applications of the technology, providing a systematic, integrated review of the advances in nucleic acid-based antiviral drugs and the potential advantages of new technologies over current treatment options. Coverage begins with the fundamentals, exploring varying topics, including harnessing RNAi to silence viral gene expression, antiviral gene editing, viral gene therapy vectors, and non-viral vectors. Subsequent sections include detailed coverage of the developing use of gene therapy for the treatment of specific infections, the principles of rational design of antivirals, and the hurdles that currently face the further advancement of gene therapy technology. Provides coverage of gene therapy for a variety of infections, including HBV, HCV, HIV, hemorrhagic fever viruses, and respiratory and other viral infections Bridges the gap between the basic science and the important medical applications of this technology Features a broad approach to the topic, including an essential overview and the applications of gene therapy, synthetic RNA, and other antiviral strategies that involve nucleic acid engineering Presents perspectives on the future use of nucleic acids as a novel class of antiviral drugs Arms the reader with the cutting-edge information needed to stay abreast of this developing field

Gene Therapy for HIV and Chronic Infections

Gene Therapy for HIV and Chronic Infections Book
Author : Ben Berkhout,Hildegund C.J. Ertl,Marc S. Weinberg
Publisher : Springer
Release : 2015-03-10
ISBN : 149392432X
Language : En, Es, Fr & De

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Book Description :

This book centers on gene therapy and gene transfer approaches to prevent or treat chronic virus infections. The main focus is on the Big Three: human immunodeficiency virus (HIV-1), hepatitis B virus (HBV) and hepatitis C virus (HCV). Ample anti-HIV drugs are currently available in the clinic and the development of an effective combination therapy has dramatically improved the lifespan and quality of life of infected individuals. A similar trend can already be recognized for HBV and HCV: the development of multiple (directly acting) antiviral drugs and plans to control or even cure the infection. However, approaches that help prevent infection, or which provide long-lasting treatment (such as a cure) remain important goals. Immunization through gene transfer vehicles encoding immunogenic viral proteins shows promise in preventing infections with complex, highly variable, viruses such as HIV-1 or HCV. Gene therapy applications for virus infections have been discussed since the early 1990’s. Whereas a true cure seems difficult to achieve for HIV-1 due to its intrinsic property to deposit its genome into that of the host, such attempts may be within reach for HCV where spontaneous viral clearance occurs in a small percentage of the infected individuals. The prospect of original gene therapy approaches may provide alternative ways to reach the same endpoint by, for example, silencing of CCR5 expression post-transcriptionally. Many alternative antiviral strategies have been developed based on a variety of novel molecular methods: e.g. ribozymes. Some studies have progressed towards pre-clinical animal models and a few antiviral gene therapies have progressed towards clinical trials. This book provides an overview of this rapidly progressing field, while focusing on the interface of gene therapy and immunology/vaccinology.

Gene Therapy for HIV Infection

Gene Therapy for HIV Infection Book
Author : Clay Smith
Publisher : Springer
Release : 2013-01-06
ISBN : 9783662118238
Language : En, Es, Fr & De

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Book Description :

ince the early 1980s, the HIV epidemic has been raging within the S 1 United States and around the world. Drug therapy for HIV infection has not been curative, prompting the search for alternative strategies to control HIV infection within infected persons. One potential alterna tive to drug therapy is a developing medical technology termed gene therapy. 2 Gene therapy involves introducing genetic elements into popu lations of cells in order to correct or prevent a pathologic process. A large number of gene therapy strategies have been developed in an at tempt to inhibit HIV expression and spread. These strategies fall into two general categories, genetic modification of cells in order to elicit an immune response against HIV and genetic modification of the target cells of HIV infection in order to block HIV expression and reproduction. In the first strategy, termed genetic immunotherapy by some, genetic material encoding HIV proteins is introduced into patient's cells in order to stimulate a cellular immune response above and beyond 3 5 that stimulated by the viral infection itself. - Two general genetic im munotherapy strategies have been developed. Genes encoding HIV pro teins have been directly injected into the dermis or muscle tissue of patients. These genes have been encoded in plasmids or viral DNA and have been injected either in the form of naked DNA or complexed with lipids.

Gene Therapy for HIV and Chronic Infections

Gene Therapy for HIV and Chronic Infections Book
Author : Ben Berkhout,Hildegund C.J. Ertl,Marc S. Weinberg
Publisher : Unknown
Release : 2015
ISBN : 9781493924332
Language : En, Es, Fr & De

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Book Description :

This volume examines gene therapy and gene transfer approaches to preventing or treating chronic virus infections, focusing on the Big Three viral pathogens- HIV, hepatitis B virus (HBV), and hepatitis C virus (HCV). It explores molecular antiviral strategies, including RNA interference, aptamer-siRNA chimeras, U1i interference, editing CCR5, alternative genetic vaccination by intramuscular gene transfers of virus vectors, and HIV latency in the context of non-coding RNA. This title is a volume of the American Society of Gene and Cell Therapy, a sub-series of the highly successful Advances in Experimental Medicine and Biology. In eleven illustrated chapters, leading international researchers contextualize the structure, operation, and impact of pathogens; examine the existing genetic and molecular research; and extract possible methods of preventing and treating chronic viral infections while evaluating the current body of knowledge. Authoritative and multifaceted, Gene Therapy for HIV and Chronic Infections is an ideal guide for researchers in the fields of gene therapy and immunology interested in expanding their knowledge on how to design an effective gene therapy against a viral pathogen.

Viruses and Man A History of Interactions

Viruses and Man  A History of Interactions Book
Author : Milton W. Taylor
Publisher : Springer
Release : 2014-07-21
ISBN : 3319077589
Language : En, Es, Fr & De

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Book Description :

Milton Taylor, Indiana University, offers an easy-to-read and fascinating text describing the impact of viruses on human society. The book starts with an analysis of the profound effect that viral epidemics had on world history resulting in demographic upheavals by destroying total populations. It also provides a brief history of virology and immunology. Furthermore, the use of viruses for the treatment of cancer (viral oncolysis or virotherapy) and bacterial diseases (phage therapy) and as vectors in gene therapy is discussed in detail. Several chapters focus on viral diseases such as smallpox, influenza, polio, hepatitis and their control, as well as on HIV and AIDS and on some emerging viruses with an interesting story attached to their discovery or vaccine development. The book closes with a chapter on biological weapons. It will serve as an invaluable source of information for beginners in the field of virology as well as for experienced virologists, other academics, students, and readers without prior knowledge of virology or molecular biology.

New Twists in Gene Therapy for Virus Infection and Cancer

New Twists in Gene Therapy for Virus Infection and Cancer Book
Author : Chen Zhong
Publisher : Unknown
Release : 2004
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download New Twists in Gene Therapy for Virus Infection and Cancer book written by Chen Zhong, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

A Guide to Human Gene Therapy

A Guide to Human Gene Therapy Book
Author : Roland W. Herzog,Sergei Zolotukhin
Publisher : World Scientific
Release : 2010
ISBN : 9814280917
Language : En, Es, Fr & De

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Book Description :

Ever since the birth of molecular biology, the tantalizing possibility of treating disease at its genetic roots has become increasingly feasible. Gene therapy - though still in its infancy - remains one of the hottest areas of research in medicine. Its approach utilizes a gene transfer vehicle ( vector) to deliver therapeutic DNA or RNA to cells of the body in order to rectify the defect that is causing the disease. Successful therapies have been reported in humans in recent years such as cures in boys with severe immune deficiencies. Moreover, gene therapy strategies are being adapted in numerous biomedical laboratories to obtain novel treatments for a variety of diseases and to study basic biological aspects of disease. Correction of disease in animal studies, is steadily gaining ground, highlighting the immense potential of gene therapy in the medical profession. This book will cover topics that are at the forefront of biomedical research such as RNA interference, viral and non-viral gene transfer systems, treatment of hematological diseases and disorders of the central nervous system.Leading experts on the respective vector or disease will contribute the individual chapters and explain cutting-edge technologies. It also gives a broad overview of the most important gene transfer vectors and most extensively studied target diseases. This comprehensive guide is therefore a must-read for anyone in the biotechnology, biomedical or medical industries seeking to further their knowledge in the area of human gene therapy.

Viral Vectors for Gene Therapy

Viral Vectors for Gene Therapy Book
Author : Otto-Wilhelm Merten,Mohamed Al-Rubeai
Publisher : Humana Press
Release : 2011-05-19
ISBN : 9781617790942
Language : En, Es, Fr & De

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Book Description :

The huge potential for gene therapy to cure a wide range of diseases has led to high expectations and a great increase in research efforts in this area, particularly in the study of delivery via viral vectors, widely considered to be more efficient than DNA transfection. In Viral Vectors for Gene Therapy: Methods and Protocols, experts in the field present a collection of their knowledge and experience featuring methodologies that involve virus production, transferring protocols, and evaluating the efficacy of gene products. While thoroughly covering the most popular viral vector systems of adenovirus, retrovirus, and adeno-associated virus, this detailed volume also explores less common viral vector systems such as baculovirus, herpes virus, and measles virus, the growing interest in which is creating a considerable demand for large scale manufacturing and purification procedures. Written in the highly successful Methods in Molecular BiologyTM series format, many chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and vital tips on troubleshooting and avoiding known pitfalls. Comprehensive and practical, Viral Vectors for Gene Therapy: Methods and Protocols provides basic principles accessible to scientists from a wide variety of backgrounds for the development of gene therapy viral products that are safe and effective.

Analysis of Viral Infection Mechanics and Their Use in the Gene Therapy Revolution

Analysis of Viral Infection Mechanics and Their Use in the Gene Therapy Revolution Book
Author : Nicholas Dean Germano,Program in Basic Medical Sciences (Interdisciplinary). Graduate School of Basic Medical Sciences. New York Medical College,New York Medical College. Graduate School of Basic Medical Sciences. Program in Basic Medical Sciences (Interdisciplinary)
Publisher : Unknown
Release : 2012
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Analysis of Viral Infection Mechanics and Their Use in the Gene Therapy Revolution book written by Nicholas Dean Germano,Program in Basic Medical Sciences (Interdisciplinary). Graduate School of Basic Medical Sciences. New York Medical College,New York Medical College. Graduate School of Basic Medical Sciences. Program in Basic Medical Sciences (Interdisciplinary), available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Understanding Viruses

Understanding Viruses Book
Author : Teri Shors
Publisher : Jones & Bartlett Learning
Release : 2009
ISBN : 9780763729325
Language : En, Es, Fr & De

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Book Description :

"Combining the molecular, clinical, and historical aspects of virology, Understanding Viruses is a textbook for the modern undergraduate virology course. The text provides an introduction to human viral diseases. Additional chapters on viral diseases of animals; the history of clinical trials, gene therapy, and xenotransplantation; prions and viroids; plant viruses; and bacteriophages add to the coverage."--Jacket.

Gene Therapy for HIV Infection

Gene Therapy for HIV Infection Book
Author : Clay Smith
Publisher : Springer Verlag
Release : 1998
ISBN : 9783540647133
Language : En, Es, Fr & De

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Book Description :

This book focuses primarily on the development of effective gene therapy approaches for HIV infection, including the improvement of gene transfer vectors, procedures for the ex-vivo manipulation and transduction of T-lymphocytes and hematopoietic stem cells, and preclinical testing of HIV inhibition strategies. It provides a balanced perspective of the many accomplishments in this field as well as the problems which need to be solved in order to develop safe and effective therapies which benefit persons with HIV infection.

A Special Report on Gene Therapy

A Special Report on Gene Therapy Book
Author : K. K. Jain,Kewal K. Jain
Publisher : John Wiley & Sons
Release : 2000-04-14
ISBN : 9780471492900
Language : En, Es, Fr & De

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Book Description :

This special report on Gene Therapy Companies by K.K. Jain provides an up-to-date overview of the gene therapy industry. It contains a wealth of very practical information on 105 companies. For each company, information is available on the people to contact, their contact details, a corporate history, the company's technologies and products, financial data, patents held, products in clinical trials, collaborations with other companies and selected publications from the company's scientists. Almost 200 companies were initially considered for inclusion but just over 100 companies were finally selected as they fulfilled the necessary criteria to be classified as a 'Gene Therapy Company,', defined broadly to include cell therapy companies. Not all of the companies devote their activity exclusively to gene therapy but they have sufficient relevance to be included. As part of this project, new companies were discovered that have not been reported in other publications or on the internet. Dr. Jain has spared no effort to ensure that the information is up-to-date and accurate at the time of publishing. In most instances, the information was reviewed by the companies to correct any outdated information or to add any complementary or recent information. In addition to the detailed descriptions of each company, the data is also presented in summary tabular form so that at a glance the reader can identify collaborations within the gene therapy industry, or determine which companies are pursuing strategies involving viral, non-viral or other approaches to gene therapy, and which diseases are being targetted. Given that much of the gene therapy research and development is currently being carried out within the industrial sector, it is important for scientists, managers and investors to have the relevant information at their fingertips. This special report provides that information in one accurate, easy to consult and up-to-date source.

Gene Therapy

Gene Therapy Book
Author : Doaa Hashad
Publisher : BoD – Books on Demand
Release : 2015-11-26
ISBN : 9535122215
Language : En, Es, Fr & De

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Book Description :

Gene therapy is becoming a promising technology for the management of many human diseases. Hereditary and acquired disorders can both be tackled using the technique of gene therapy. This book provides detailed, up-to-date topics addressing basic principles of gene therapy and discussing some of the challenges encountered by scientists in developing this relatively novel technology. The development of new and efficient gene transfer vectors is of utmost importance in the progress of the field of gene therapy. Both viral and non-viral vectors are extensively discussed. A detailed chapter elaborates the problem of host immune rejection of transplanted donor cells or engineered tissue that can be avoided using the encapsulation of transgenic cells, thus avoiding the use of drugs that achieve immunosuppression.

Antisense Gene Therapy for RNA Viruses

Antisense Gene Therapy for RNA Viruses Book
Author : Arlene Stecenko
Publisher : Unknown
Release : 1903
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

A vector and methods of inhibiting replication of an RNA virus which replicates in the cytoplasm of a cell in a subject, comprising administering to the cell of the subject a composition comprising a vector comprising a promoter functionally linked to a nucleic acid comprising a viral gene, wherein the nucleic acid is in antisense orientation relative to the promoter and wherein the cell is capable of promoting expression from the promoter, thereby transcribing the nucleic acid and inhibiting replication of the RNA virus in the subject. In particular, provided are vectors and methods for treating a respiratory syncytial virus infection.

Gene Therapy

Gene Therapy Book
Author : Nancy Smyth Templeton,D. D. Lasic
Publisher : CRC Press
Release : 2000-06-15
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

This text covers all aspects of gene therapy, including basic principles, viral and nonviral delivery systems, targeted diseases, regulatory issues, and FDA requirements. It investigates genetic bullets to block HIV-1 replication and genetic guns to deliver antiviral agents.

Gene Therapy

Gene Therapy Book
Author : Joseph Panno
Publisher : Infobase Publishing
Release : 2005
ISBN : 0816067341
Language : En, Es, Fr & De

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Book Description :

Many diseases are caused by a simple point mutation.

Viral Vectors for Gene Therapy

Viral Vectors for Gene Therapy Book
Author : Otto-Wilhelm Merten,Mohamed Al-Rubeai
Publisher : Springer Science+Business Media
Release : 2011
ISBN : 9781617790959
Language : En, Es, Fr & De

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Book Description :

The huge potential for gene therapy to cure a wide range of diseases has led to high expectations and a great increase in research efforts in this area, particularly in the study of delivery via viral vectors, widely considered to be more efficient than DNA transfection. In Viral Vectors for Gene Therapy: Methods and Protocols, experts in the field present a collection of their knowledge and experience featuring methodologies that involve virus production, transferring protocols, and evaluating the efficacy of gene products. While thoroughly covering the most popular viral vector systems of adenovirus, retrovirus, and adeno-associated virus, this detailed volume also explores less common viral vector systems such as baculovirus, herpes virus, and measles virus, the growing interest in which is creating a considerable demand for large scale manufacturing and purification procedures. Written in the highly successful Methods in Molecular Biology series format, many chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and vital tips on troubleshooting and avoiding known pitfalls. Comprehensive and practical, Viral Vectors for Gene Therapy: Methods and Protocols provides basic principles accessible to scientists from a wide variety of backgrounds for the development of gene therapy viral products that are safe and effective.

Adenovirus based Gene Therapy Approaches for Chronic Hepatitis B Virus Infection

Adenovirus based Gene Therapy Approaches for Chronic Hepatitis B Virus Infection Book
Author : Maren Schiwon
Publisher : Unknown
Release : 2017
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Adenovirus based Gene Therapy Approaches for Chronic Hepatitis B Virus Infection book written by Maren Schiwon, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Directed Retroviral Motion as a Means of Enhancing Gene Transfer for Gene Therapy

Directed Retroviral Motion as a Means of Enhancing Gene Transfer for Gene Therapy Book
Author : Alice Siw Ying Chuck
Publisher : Unknown
Release : 1995
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Directed Retroviral Motion as a Means of Enhancing Gene Transfer for Gene Therapy book written by Alice Siw Ying Chuck, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Lentiviral Vectors and Gene Therapy

Lentiviral Vectors and Gene Therapy Book
Author : David Escors,Karine Breckpot,Frederick Arce,Grazyna Kochan,Holly Stephenson
Publisher : Springer Science & Business Media
Release : 2012-03-22
ISBN : 3034804024
Language : En, Es, Fr & De

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Book Description :

Gene therapy was conceived during the early and mid part of the 20th century. At first, it was considered a revolutionary biomedical procedure, which could potentially cure any disease for which the molecular bases were understood. Since then, gene therapy has gone through many stages and has evolved from a nearly unrealistic perspective to a real life application. Clinical efficacy in humans was demonstrated at the beginning of this century after its successful application in small-scale clinical trials to cure severe immunodeficiency in children. However, their successes were overshadowed some time later by the occurrence of vector-related leukaemia in a number of treated children. It is in this context that lentiviral vectors have appeared, with improved efficiency and, possibly, increased biosafety. Very recently, the first clinical trials with lentivectors have been carried out with some success. This Brief firstly defines gene therapy, and places lentivectors within this fascinating therapeutic strategy. Then follows a comprehensive description of the development of retroviral and lentiviral vectors and how to specifically target distinct cell types and tissues. The authors also discuss the application of lentivector gene therapy for the treatment of cancer and autoimmune diseases, ending with the application of lentivectors in human gene therapy clinical trials.