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Gene Environment Interactions in Psychiatry

Gene Environment Interactions in Psychiatry Book
Author : Bart Ellenbroek,Ji Un Youn
Publisher : Academic Press
Release : 2016-07-26
ISBN : 012801783X
Language : En, Es, Fr & De

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Book Description :

Gene-Environment Interactions in Psychiatry: Nature, Nurture, Neuroscience begins with the basic aspects of gene–environment studies, such as basic genetics, principles of animals modeling, and the basic processes of how environmental factors affect brain and behavior, with part two describing the most important psychiatric disorders in detail. Each chapter has a similar structure that includes a general description of the disorder that is followed by an analysis of the role of genes and how they are affected by environmental factors. Each chapter ends with a description of the most relevant animal models, again focusing on gene–environment interactions. The book concludes with a critical evaluation of the current research and an outlook for the (possible) future, offering a vignette into the fascinating world of nature, nurture, and neuroscience. Written to provide in-depth basic knowledge on gene–environment interactions for graduate students, postgraduate students, clinicians, and scientists Includes descriptions of the major psychiatric disorders Provides detailed descriptions of animal models and basic genetic information Presents well-illustrated color figures to explain complex features in a simple manner

Gene Environment Interactions

Gene Environment Interactions Book
Author : Moyra Smith
Publisher : Academic Press
Release : 2020-01-24
ISBN : 0128196130
Language : En, Es, Fr & De

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Book Description :

Gene Environment Interactions: Nature and Nurture in the Twenty-first Century offers a rare, synergistic view of ongoing revelations in gene environment interaction studies, drawing together key themes from epigenetics, microbiomics, disease etiology, and toxicology to illuminate pathways for clinical translation and the paradigm shift towards precision medicine. Across eleven chapters, Dr. Smith discusses interactions with the environment, human adaptations to environmental stimuli, pathogen encounters across the centuries, epigenetic modulation of gene expression, transgenerational inheritance, the microbiome's intrinsic effects on human health, and the gene-environment etiology of cardiovascular, metabolic, psychiatric, behavioral and monogenic disorders. Later chapters illuminate how our new understanding of gene environment interactions are driving advances in precision medicine and novel treatments. In addition, the book's author shares strategies to support clinical translation of these scientific findings to improve heath literacy among the general population. Offers a thorough, interdisciplinary discussion on recent revelations from gene environment interaction studies Illuminates environmental factors affecting disease-gene etiology and treatment Supports the clinical translation of gene environment interaction findings into novel therapeutics and precision medicine

Statistical Approaches to Gene x Environment Interactions for Complex Phenotypes

Statistical Approaches to Gene x Environment Interactions for Complex Phenotypes Book
Author : Michael Windle
Publisher : MIT Press
Release : 2016-07-08
ISBN : 0262335514
Language : En, Es, Fr & De

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Book Description :

Diverse methodological and statistical approaches for investigating the role of gene-environment interactions in a range of complex diseases and traits. Findings from the Human Genome Project and from Genome-Wide Association (GWA) studies indicate that many diseases and traits manifest a more complex genomic pattern than previously assumed. These findings, and advances in high-throughput sequencing, suggest that there are many sources of influence—genetic, epigenetic, and environmental. This volume investigates the role of the interactions of genes and environment (G × E) in diseases and traits (referred to by the contributors as complex phenotypes) including depression, diabetes, obesity, and substance use. The contributors first present different statistical approaches or strategies to address G × E and G × G interactions with high-throughput sequenced data, including two-stage procedures to identify G × E and G × G interactions, marker-set approaches to assessing interactions at the gene level, and the use of a partial-least square (PLS) approach. The contributors then turn to specific complex phenotypes, research designs, or combined methods that may advance the study of G × E interactions, considering such topics as randomized clinical trials in obesity research, longitudinal research designs and statistical models, and the development of polygenic scores to investigate G × E interactions. Contributors Fatima Umber Ahmed, Yin-Hsiu Chen, James Y. Dai, Caroline Y. Doyle, Zihuai He, Li Hsu, Shuo Jiao, Erin Loraine Kinnally, Yi-An Ko, Charles Kooperberg, Seunggeun Lee, Arnab Maity, Jeanne M. McCaffery, Bhramar Mukherjee, Sung Kyun Park, Duncan C. Thomas, Alexandre Todorov, Jung-Ying Tzeng, Tao Wang, Michael Windle, Min Zhang

Gene Environment Interaction Analysis

Gene Environment Interaction Analysis Book
Author : Sumiko Anno
Publisher : CRC Press
Release : 2016-03-30
ISBN : 9814669644
Language : En, Es, Fr & De

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Book Description :

Gene–environment (G × E) interaction analysis is a statistical method for clarifying G × E interactions applicable to a phenotype or a disease that is the result of interactions between genes and the environment. This book is the first to deal with the theme of G × E interaction analysis. It compiles and details cutting-edge research in bioinformatics and computational biology and will appeal to anyone involved in bioinformatics and computational biology.

Gene Environment Interactions

Gene Environment Interactions Book
Author : Lucio G. Costa,David L. Eaton
Publisher : John Wiley & Sons
Release : 2005-12-16
ISBN : 0471758035
Language : En, Es, Fr & De

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Book Description :

Understanding the play between heredity and environment, andrelating it to disease causation, is the task of ecogenetics.Gene-Environment Interactions: Fundamentals of Ecogenetics presentsthe first comprehensive survey of this discipline, reflecting itsrelationship with toxicology, epidemiology, pharmacology, publichealth, and other medical and biological fields. Divided into four sections, the text elucidates key basic andadvanced topics: * Section 1 covers fundamentals, including the history of thediscipline, a discussion of the molecular laboratory toolscurrently available to assess genotypes, using such measurements inmolecular epidemiology studies, and the statistical issues involvedin their analysis. * Section 2 focuses on a number of key genetic polymorphismsrelevant for ecogenetics, including enzymes of phase I and phase IImetabolism, enzymes involved in DNA repair, as well as receptorsand ion channels. This highlights characteristics of selected,widely studied genotypic/phenotypic differences, and allowsdiscussion of how given genetic variations can influence responsesto exogenous chemicals. * Section 3 examines gene-environment interactions through adisease-based approach, addressing how genetic polymorphisms caninfluence susceptibility to various diseases. Chapters coverimportant disease conditions such as various types of cancer,neurodegenerative diseases, cardiovascular disease, chronicpulmonary diseases, infectious diseases, diabetes, andobesity. * The final section discusses the ethical, legal, and social issuesthat arise when investigating and evaluating genetic polymorphismsin human populations, as well as the impact of ecogenetics on riskassessment, regulatory policies, and medicine and publichealth. Packed with clear examples illustrating concepts, as well asnumerous tables and figures, Gene-Environment Interactions:Fundamentals of Ecogenetics is a unique resource for a wide rangeof physicians, students, and other specialists.

Environmental Epigenetics

Environmental Epigenetics Book
Author : L. Joseph Su,Tung-chin Chiang
Publisher : Springer
Release : 2015-05-18
ISBN : 1447166787
Language : En, Es, Fr & De

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Book Description :

This book examines the toxicological and health implications of environmental epigenetics and provides knowledge through an interdisciplinary approach. Included in this volume are chapters outlining various environmental risk factors such as phthalates and dietary components, life states such as pregnancy and ageing, hormonal and metabolic considerations and specific disease risks such as cancer cardiovascular diseases and other non-communicable diseases. Environmental Epigenetics imparts integrative knowledge of the science of epigenetics and the issues raised in environmental epidemiology. This book is intended to serve both as a reference compendium on environmental epigenetics for scientists in academia, industry and laboratories and as a textbook for graduate level environmental health courses. Environmental Epigenetics imparts integrative knowledge of the science of epigenetics and the issues raised in environmental epidemiology. This book is intended to serve both as a reference compendium on environmental epigenetics for scientists in academia, industry and laboratories and as a textbook for graduate level environmental health courses.

Genes Behavior and the Social Environment

Genes  Behavior  and the Social Environment Book
Author : Institute of Medicine,Board on Health Sciences Policy,Committee on Assessing Interactions Among Social, Behavioral, and Genetic Factors in Health
Publisher : National Academies Press
Release : 2006-12-07
ISBN : 0309101964
Language : En, Es, Fr & De

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Book Description :

Over the past century, we have made great strides in reducing rates of disease and enhancing people's general health. Public health measures such as sanitation, improved hygiene, and vaccines; reduced hazards in the workplace; new drugs and clinical procedures; and, more recently, a growing understanding of the human genome have each played a role in extending the duration and raising the quality of human life. But research conducted over the past few decades shows us that this progress, much of which was based on investigating one causative factor at a time—often, through a single discipline or by a narrow range of practitioners—can only go so far. Genes, Behavior, and the Social Environment examines a number of well-described gene-environment interactions, reviews the state of the science in researching such interactions, and recommends priorities not only for research itself but also for its workforce, resource, and infrastructural needs.

Cancer and the Environment

Cancer and the Environment Book
Author : Institute of Medicine,Board on Health Sciences Policy,Roundtable on Environment Health Sciences, Research, and Medicine
Publisher : National Academies Press
Release : 2002-09-01
ISBN : 030908475X
Language : En, Es, Fr & De

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Book Description :

The Roundtable on Environmental Health Sciences, Research, and Medicine wanted to address the link between environmental factors and the development of cancer in light of recent advances in genomics. They asked what research tools are needed, how new scientific information can be applied in a timely manner to reduce the burden of cancer, and how this can be flexible enough to treat the individual.

Epigenomics in Health and Disease

Epigenomics in Health and Disease Book
Author : Mario Fraga,Agustin Fernandez Fernandez
Publisher : Academic Press
Release : 2015-10-12
ISBN : 0128004967
Language : En, Es, Fr & De

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Book Description :

Epigenomics in Health and Disease discusses the next generation sequencing technologies shaping our current knowledge with regards to the role of epigenetics in normal development, aging, and disease. It includes the consequences for diagnostics, prognostics, and disease-based therapies made possible by the study of the complete set of epigenetic modifications to the genetic material of human cells. With coverage pertinent to both basic biology and translational research, the book will be of particular interest for medical and bioscience researchers and students seeking current translational knowledge in epigenesis and epigenomics. Coverage includes the latest findings on epigenome-wide research in disease-based profiling, epidemiological implications, epigenome-wide epigenetic studies, the cancer epigenome, and other pervasive disease categories. Presents critical reviews that provide the means for reviewing and analyzing the epigenome as a whole, also discussing its translational potential Combines basic epigenomic knowledge with methodological and biostatistical topics related to technology and data analysis Includes coverage of relatively new topics, including DNA methylation dynamics during development and differentiation, genome-wide histone post-translational modifications during development and differentiation, and genome-wide DNA methylation changes during aging

Beyond Our Genes

Beyond Our Genes Book
Author : Raffaele Teperino
Publisher : Springer Nature
Release : 2020-01-24
ISBN : 3030352137
Language : En, Es, Fr & De

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Book Description :

The genotype/phenotype dichotomy is being slowly replaced by a more complex relationship whereby the majority of phenotypes arise from interactions between one’s genotype and the environment in which one lives. Interestingly, it seems that not only our lives, but also our ancestors’ lives, determine how we look. This newly recognized form of inheritance is known as (epi)genetic, as it involves an additional layer of information on top of the one encoded by the genes. Its discovery has constituted one of the biggest paradigm shifts in biology in recent years. Understanding epigenetic factors may help explain the pathogenesis of several complex human diseases (such as diabetes, obesity and cancer) and provide alternative paths for disease prevention, management and therapy. This book introduces the reader to the importance of the environment for our own health and the health of our descendants, sheds light on the current knowledge on epigenetic inheritance and opens a window to future developments in the field.

The Wiley Encyclopedia of Personality and Individual Differences Personality Processes and Individuals Differences

The Wiley Encyclopedia of Personality and Individual Differences  Personality Processes and Individuals Differences Book
Author : Annamaria Di Fabio,Donald H. Saklofske,Con Stough
Publisher : John Wiley & Sons
Release : 2020-11-03
ISBN : 1119795257
Language : En, Es, Fr & De

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Book Description :

Volume 3, Personality Processes and Individuals Differences of The Wiley Encyclopedia of Personality and Individual Differences The Encyclopedia of Personality and Individual Differences (EPID) is organized into four volumes that look at the many likenesses and differences between individuals. Each of these four volumes focuses on a major content area in the study of personality psychology and individuals' differences. The first volume, Models and Theories, surveys the significant classic and contemporary viewpoints, perspectives, models, and theoretical approaches to the study of personality and individuals' differences (PID). The second volume on Measurement and Assessment examines key classic and modern methods and techniques of assessment in the study of PID. Volume III, titled Personality Processes and Individuals Differences, covers the important traditional and current dimensions, constructs, and traits in the study of PID. The final volume discusses three major categories: clinical contributions, applied research, and cross-cultural considerations, and touches on topics such as culture and identity, multicultural identities, cross-cultural examinations of trait structures and personality processes, and more. Each volume contains approximately 100 entries on personality and individual differences written by a diverse international panel of leading psychologists Covers significant classic and contemporary personality psychology models and theories, measurement and assessment techniques, personality processes and individuals differences, and research Provides a comprehensive and in-depth overview of the field of personality psychology The Encyclopedia of Personality and Individual Differences is an important resource for all psychology students and professionals engaging in the study and research of personality.

Bipolar Disorder Vulnerability

Bipolar Disorder Vulnerability Book
Author : Jair Soares,Consuelo Walss-Bass,Paolo Brambilla
Publisher : Academic Press
Release : 2018-06-09
ISBN : 0128125608
Language : En, Es, Fr & De

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Book Description :

Bipolar Disorder Vulnerability: Perspectives from Pediatric and High-Risk Populations synthesizes our current understanding of high-risk and pediatric populations to aid readers in identifying markers of vulnerability for the development of bipolar disorder, with an ultimate goal of the development of drug targets and other therapies for early diagnosis and treatment. The book provides readers with an understanding of biological and environmental factors influencing disease manifestation that will aid them in defining discrete clinical stages and, importantly, establish an empirical basis for the application of novel therapeutics in a phase of illness during which specific treatments could more effectively alter disease course. Whereas most of the literature available on the pathophysiological mechanisms of bipolar disorder focuses on chronically ill adult individuals, this represents the only book that specifically examines pediatric and high-risk populations. An estimated 30 to 60 percent of adult bipolar disorder patients have their disease onset during childhood, with early-onset cases representing a particularly severe and genetically loaded form of the illness. Highlights diverse translational methodologies, including functional and structural neuroimaging, neuropsychological testing and integrated genomics Examines molecular trajectories in youth with bipolar disorder and unaffected youth at high risk for developing bipolar disorder Explores the interaction between genomic and environmental influences that shape behavior

The Neurobiological Basis of Suicide

The Neurobiological Basis of Suicide Book
Author : Yogesh Dwivedi
Publisher : CRC Press
Release : 2012-06-25
ISBN : 143983881X
Language : En, Es, Fr & De

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Book Description :

With recent studies using genetic, epigenetic, and other molecular and neurochemical approaches, a new era has begun in understanding pathophysiology of suicide. Emerging evidence suggests that neurobiological factors are not only critical in providing potential risk factors but also provide a promising approach to develop more effective treatment and prevention strategies. The Neurobiological Basis of Suicide discusses the most recent findings in suicide neurobiology. Psychological, psychosocial, and cultural factors are important in determining the risk factors for suicide; however, they offer weak prediction and can be of little clinical use. Interestingly, cognitive characteristics are different among depressed suicidal and depressed nonsuicidal subjects, and could be involved in the development of suicidal behavior. The characterization of the neurobiological basis of suicide is in delineating the risk factors associated with suicide. The Neurobiological Basis of Suicide focuses on how and why these neurobiological factors are crucial in the pathogenic mechanisms of suicidal behavior and how these findings can be transformed into potential therapeutic applications.

Genotype X Environment Interactions

Genotype X Environment Interactions Book
Author : Paolo Annicchiarico
Publisher : Food & Agriculture Org.
Release : 2002
ISBN : 9789251048702
Language : En, Es, Fr & De

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Book Description :

The projected increase in world population levels and the subsequent rise in food demand represents a huge challenge for agricultural production systems worldwide. This publication examines the opportunities and challenges raised by the use of plant genetic resources and highlights the contribution that data from multi-environment yield trials can provide for the definition of adaptation strategies and yield stability targets in plant breeding programmes. It contains a case study about a durum wheat crop programme in Algeria, and also includes a CD-ROM with data from IRRISTAT, a programme developed by the International Rice Research Institute (IRRI).

Gene Environment Transactions in Developmental Psychopathology

Gene Environment Transactions in Developmental Psychopathology Book
Author : Patrick H. Tolan,Bennett L. Leventhal
Publisher : Springer
Release : 2017-04-29
ISBN : 3319492276
Language : En, Es, Fr & De

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Book Description :

This book examines the current research in gene-environment transactions (GEX) and its potential use in developing interventions and applications tailored to individual genetic makeups. Key concepts underlying GEX studies in this area are defined, identifying fundamental challenges in devising informed research questions and conducting valid and useful experiments. Chapters analyze GEX models inspired by the present day genome-based frameworks, particularly in terms of advances in identifying and understanding complex environmental factors, using examples from common psychological conditions, such as antisocial behavior, chronic physical aggression, and chronic internalizing disorder. In addition, the book presents new and potential applications of the framework in the contexts of prevention science and intervention research. Topics featured in this book include: Epigenetics and the biology of gene x environment interactions. Gene by environment interactions and its potential use for intervention strategies in anxiety disorders. The challenges and potential for research on gene-environment interactions within autism spectrum disorder. Using genetically informed prevention trials to test gene x environment hypothese. Challenges for intervention research within the GEX framework. Gene-Environment Transactions in Developmental Psychopathology is a must-have resource for researchers/professors, clinicians, and related professionals as well as graduate students in developmental psychology, psychiatry, human genetics, and related disciplines.

Handbook of Statistical Methods for Case Control Studies

Handbook of Statistical Methods for Case Control Studies Book
Author : Ørnulf Borgan,Norman Breslow,Nilanjan Chatterjee,Mitchell H. Gail,Alastair Scott,Chris J. Wild
Publisher : CRC Press
Release : 2018-06-27
ISBN : 1351650122
Language : En, Es, Fr & De

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Book Description :

Handbook of Statistical Methods for Case-Control Studies is written by leading researchers in the field. It provides an in-depth treatment of up-to-date and currently developing statistical methods for the design and analysis of case-control studies, as well as a review of classical principles and methods. The handbook is designed to serve as a reference text for biostatisticians and quantitatively-oriented epidemiologists who are working on the design and analysis of case-control studies or on related statistical methods research. Though not specifically intended as a textbook, it may also be used as a backup reference text for graduate level courses. Book Sections Classical designs and causal inference, measurement error, power, and small-sample inference Designs that use full-cohort information Time-to-event data Genetic epidemiology About the Editors Ørnulf Borgan is Professor of Statistics, University of Oslo. His book with Andersen, Gill and Keiding on counting processes in survival analysis is a world classic. Norman E. Breslow was, at the time of his death, Professor Emeritus in Biostatistics, University of Washington. For decades, his book with Nick Day has been the authoritative text on case-control methodology. Nilanjan Chatterjee is Bloomberg Distinguished Professor, Johns Hopkins University. He leads a broad research program in statistical methods for modern large scale biomedical studies. Mitchell H. Gail is a Senior Investigator at the National Cancer Institute. His research includes modeling absolute risk of disease, intervention trials, and statistical methods for epidemiology. Alastair Scott was, at the time of his death, Professor Emeritus of Statistics, University of Auckland. He was a major contributor to using survey sampling methods for analyzing case-control data. Chris J. Wild is Professor of Statistics, University of Auckland. His research includes nonlinear regression and methods for fitting models to response-selective data.

The Science of Expertise

The Science of Expertise Book
Author : David Z. Hambrick,Guillermo Campitelli,Brooke N. Macnamara
Publisher : Routledge
Release : 2017-09-22
ISBN : 1351624830
Language : En, Es, Fr & De

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Book Description :

Offering the broadest review of psychological perspectives on human expertise to date, this volume covers behavioral, computational, neural, and genetic approaches to understanding complex skill. The chapters show how performance in music, the arts, sports, games, medicine, and other domains reflects basic traits such as personality and intelligence, as well as knowledge and skills acquired through training. In doing so, this book moves the field of expertise beyond the duality of "nature vs. nurture" toward an integrative understanding of complex skill. This book is an invaluable resource for researchers and students interested in expertise, and for professionals seeking current reviews of psychological research on expertise.

Genetic Effects on Environmental Vulnerability to Disease

Genetic Effects on Environmental Vulnerability to Disease Book
Author : Sir Michael J. Rutter
Publisher : Wiley
Release : 2008-10-20
ISBN : 9780470777800
Language : En, Es, Fr & De

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Book Description :

Much research has attempted to show direct linear relations between genes and disorder. However, scientists have been discouraged by inconsistent findings based on this simple gene-phenotype approach. The alternative approach is to incorporate information about the environment. A gene-environment interaction approach assumes that environmental pathogens cause disorder, whereas genes influence susceptibility to environmental pathogens. This book brings together contributions from experts from multiple disciplines who discuss: How epidemiological cohort studies can better integrate physiological (mechanistic) measures; How best to characterise subjects’ vulnerability versus resilience by moving beyond single genetic polymorphisms; How gene hunters can benefit from recruiting samples selected for known exposures; How environmental pathogens can be used as tools for gene hunting; How to deal with potential spurious (statistical) interactions, and How genes can help explain fundamental demographic properties of disorders (e.g. sex distribution, age effects).

Chesley s Hypertensive Disorders in Pregnancy

Chesley s Hypertensive Disorders in Pregnancy Book
Author : Robert N. Taylor,James M. Roberts,F. Gary Cunningham,Marshall D. Lindheimer
Publisher : Elsevier
Release : 2014-08-28
ISBN : 0124079458
Language : En, Es, Fr & De

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Book Description :

Chesley’s Hypertensive Disorders in Pregnancy continues its tradition as one of the beacons to guide the field of preeclampsia research, recognized for its uniqueness and utility. Hypertensive disorders remain one the major causes of maternal and fetal morbidity and death. It is also a leading cause of preterm birth now known to be a risk factor in remote cardiovascular disease. Despite this the hypertensive disorders remain marginally studied and management is often controversial. The fourth edition of Chesley’s Hypertensive Disorders in Pregnancy focuses on prediction, prevention, and management for clinicians, and is an essential reference text for clinical and basic investigators alike. Differing from other texts devoted to preeclampsia, it covers the whole gamut of high blood pressure, and not just preeclampsia. Features new chapters focusing on recent discoveries in areas such as fetal programming, genomics/proteomics, and angiogenesis Includes extensive updates to chapters on epidemiology, etiological considerations, pathophysiology, prediction, prevention, and management Discusses the emerging roles of metabolic syndrome and obesity and the increasing incidence of preeclampsia Each section overseen by one of the editors; each chapter co-authored by one of the editors, ensuring coherence throughout book

Neuronal and Synaptic Dysfunction in Autism Spectrum Disorder and Intellectual Disability

Neuronal and Synaptic Dysfunction in Autism Spectrum Disorder and Intellectual Disability Book
Author : Carlo Sala,Chiara Verpelli
Publisher : Academic Press
Release : 2016-04-30
ISBN : 0128005335
Language : En, Es, Fr & De

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Book Description :

Neuronal and Synaptic Dysfunction in Autism Spectrum Disorder and Intellectual Disability provides the latest information on Autism spectrum disorders (ASDs), the lifelong neurodevelopmental disorders that present in early childhood and affect how individuals communicate and relate to others and their surroundings. In addition, three quarters of ASD patients also manifest severe intellectual disability. Though certain genes have been implicated, ASDs remain largely a mystery, and research looking into causes and cellular deficits are crucial for better understanding of neurodevelopmental disorders. Despite the prevalence and insidious nature of this disorder, this book remains to be an extensive resource of information and background on the state of current research in the field. The book serves as a reference for this purpose, and discusses the crucial role synaptic activity plays in proper brain function. In addition, the volume discusses the neurodevelopmental synaptopathies and serves as a resource for scientists and clinicians in all biomedical science specialties. This research has been crucial for recent studies that have provided a rationale for the development of pharmacological agents able to counteract functional synaptic anomalies and potentially ameliorate some ASD symptoms. Introduces the genetic and non-genetic causes of autism and associated intellectual disabilities Describes the genes implicated in autistic spectrum disorders and their function Considers major individual genetic causes of autism, Rett syndrome, Fragile X syndrome, and other autism spectrum disorders, as well as their classification as synaptopathies Presents a thorough discussion of the clinical aspects of multiple neurodevelopmental disorders and the experimental models that exist to study their pathophysiology in vitro and in vivo, including animal models and patient-derived stem cell culture