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Functionalised Cardiovascular Stents

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Functionalised Cardiovascular Stents

Functionalised Cardiovascular Stents Book
Author : Gerard Wall,Halina Podbielska,Magdalena Wawrzynska
Publisher : Woodhead Publishing
Release : 2018-02-06
ISBN : 0081004982
Language : En, Es, Fr & De

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Book Description :

Cardiovascular disease is a major cause of mortality in the western world and about half of these deaths are caused by coronary artery disease. One of the most commonly used interventions to treat arterial blockages is to deploy an arterial stent to keep the vessel open. Traditionally, some cardiovascular stents have been associated with serious side-effects, such as thrombosis. This book describes the fundamentals of cardiovascular stents, technologies to functionalize their surfaces and the market status of these important implants. The chapters provide specific focus on the production and evolution of cardiovascular stents, providing essential knowledge for researchers on advances in the field and knowledge of how cardiovascular stents are currently being "functionalized" in order to improve their biocompatibility and minimize negative outcomes in vivo. Provides a specific focus on cardiovascular stents Includes a range of topics covering the fundamentals, surface modification and biofunctionalization Provides essential knowledge for researchers on advances in the field

Functionalized Cardiovascular Stents

Functionalized Cardiovascular Stents Book
Author : J. Gerard Wall,Halina Podbielska,Magdalena Wawrzyńska
Publisher : Unknown
Release : 2018
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Functionalized Cardiovascular Stents book written by J. Gerard Wall,Halina Podbielska,Magdalena Wawrzyńska, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Functionalised Cardiovascular Stents

Functionalised Cardiovascular Stents Book
Author : Gerard Wall,Halina Podbielska,Magdalena Wawrzynska
Publisher : Woodhead Publishing Limited
Release : 2017-10-01
ISBN : 9780081004968
Language : En, Es, Fr & De

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Book Description :

Cardiovascular disease is a major cause of mortality in the western world and about half of these deaths are caused by coronary artery disease. One of the most commonly used implants to treat these arterial blockages is to deploy an arterial stent to keep the vessel open. Traditionally cardiovascular stents have been associated with serious side-effects, such as thrombosis. Research is being developed to 'functionalise' cardiovascular stents in order to improve their biocompatibility and minimise side-effects. This book describes the fundamentals of cardiovascular stents, technologies to functionalise their surfaces and the market status of these important implants. Provides a specific focus on cardiovascular stents Includes a range of topics coverering the fundamentals, surface modification and biofunctionalisation Provides essential knowledge for researchers on advances in the field

Novel Functionalized and Patterned Surfaces for Cardiovascular Applications

Novel Functionalized and Patterned Surfaces for Cardiovascular Applications Book
Author : Romain Schieber
Publisher : Unknown
Release : 2018
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Novel Functionalized and Patterned Surfaces for Cardiovascular Applications book written by Romain Schieber, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Coronary Artery Disease and The Evolution of Angioplasty Devices

Coronary Artery Disease and The Evolution of Angioplasty Devices Book
Author : Martin W. King,Tushar Bambharoliya,Harshini Ramakrishna,Fan Zhang
Publisher : Springer Nature
Release : 2020-05-18
ISBN : 303042443X
Language : En, Es, Fr & De

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Book Description :

In this concise but authoritative book, the authors take the reader through the epidemiology, risk factors and the basic mechanism of coronary artery disease. In addition, they explain how coronary microvascular dysfunction can lead to angina, even after successful angioplasty following a heart attack. The methods for diagnosis and the options for treatment are explained, ending with a discussion of the evolution of coronary angioplasty from balloon catheters to novel, fully resorbable polymeric drug eluting stents. Enclosed is a list of currently available commercial devices, as well as a listing of experimental products under research and development, so that readers can appreciate the serious nature of this disease and have an understanding of how the medical device sector is attempting to address this major healthcare problem. Globally in 2010, ischemic heart disease was the cause of 13.3% of all deaths. In the US alone, the direct medical costs from coronary artery disease and stroke are currently estimated to be $126 billion per year, and are expected to rise to $309 billion by 2035.

2D Functionalized Films and 3D Direct Printed Patterned PLLA Stents for Cardiovascular Applications

2D Functionalized Films and 3D Direct Printed Patterned PLLA Stents for Cardiovascular Applications Book
Author : Santiago Raymond Llorens
Publisher : Unknown
Release : 2016
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download 2D Functionalized Films and 3D Direct Printed Patterned PLLA Stents for Cardiovascular Applications book written by Santiago Raymond Llorens, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

A Study of Nanostructured Materials Toward Coronary Artery Stenting and DNA based Biosensing

A Study of Nanostructured Materials Toward Coronary Artery Stenting and DNA based Biosensing Book
Author : John E. Jones
Publisher : Unknown
Release : 2015
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Nanostructured materials were investigated for the following applications: (i) ultrathin (20-30 nm) plasma nanocoatings for reduction of restenosis and subsequent blockage in coronary artery stents and (ii) DNA-functionalized anodized aluminum oxide (AAO) filtration membranes for detection of pathogenic group B Streptococcus (GBS). For vascular stent application, plasma nanocoatings were deposited onto stainless steel substrates (i.e., coupons and coronary artery stents) using a low pressure, nonequilibrium plasma glow discharge. Coatings were deposited utilizing either a direct current (DC) or a radio frequency (RF) plasma glow discharge. Coating wettabilities and potential in vitro physiological interactions were enhanced using subsequent NH3/O2 plasma treatment. For validation, cell cultures were carried out utilizing porcine coronary artery smooth muscle cells and endothelial cells. Radiolabelled porcine platelets were also utilized in a stent perfusion circuit to better mimic the shearing stresses from blood flow. Human platelet and leukocyte adhesion studies were also conducted using eosinlabeled cells and their attachment behaviors to plasma-coated metal coupons were studied. To determine the coating surface chemistry, analyses were conducted utilizing X-ray photoelectron spectroscopy (XPS) and Fourier transform infrared spectroscopy (FTIR). Coating corrosion resistance and barrier adhesion properties were assessed with cyclic polarization and electrochemical impedance spectroscopy (EIS), respectively. The results indicate that the coatings can minimize smooth muscle cell attachment while also improving endothelial cell response. Platelet and leukocyte attachment densities were significantly lower for surface modified NH3+O2 conditions, suggesting reduced risk of thrombosis and inflammation. Based on surface analysis, polar nitrogen functional groups may contribute to the improved vascular response. Electrochemical testing results also showed that stent nanocoatings resulted in higher corrosion resistance of the stent materials. Such results indicate that plasma nanocoatings may potentially minimize further inflammatory responses from metal corrosion particles. Continuing the discussion on nanostructured materials, commercially available anodized aluminum oxide (AAO) filtration membranes were utilized as a substrate for fabrication of a DNA-based biosensor. Biosensors were assembled using an electroless gold plating method for the preparation of conductive AAO disks. The gold-coated disks were subsequently functionalized with single-stranded DNA probes that are specific for the detection of the GBS pathogen. Additional substrates were functionalized with locked nucleic acids (LNAs), which may result in more efficient DNA hybridization. Probe nucleic acids were immersed in solutions containing single-stranded GBS DNA derived from bacterial culture or from clinical swabs. The biosensor was able to detect GBS DNA down to 6 × 101 copies. Binding was specific as there was minimal crossreaction with other non-group B streptococcal isolates. Clinical test results are promising, and a probe specific for bacterial reproduction gave suitable results. Further refinement may be necessary before future clinical application.

Elastin like Polymer Coating on CoCr Surfaces for Cardiovascular Applications

Elastin like Polymer Coating on CoCr Surfaces for Cardiovascular Applications Book
Author : Anne-Sophie Zenses
Publisher : Unknown
Release : 2013
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Cardiovascular diseases have emerged as a major concern since they are the first cause of death in developed countries. The advent of percutaneous transluminal coronary angioplasty consisted in an alternative to invasive surgery. Especially the introduction of cardiovascular stents has significantly meliorated the potential of angioplasty, e.g. with the use of drug eluting and bioadsorbable stents. Still, restenosis remains a major implant-related complication and can imply re intervention. Therefore, research has focused on limiting and/r avoided restenosis by investigating the field of surface treatments and drug delivery material. The rapidly developing field of material technology and engineering has enable design of molecular-specific surfaces for a new generation of vascular devices. This project has been focused on how to promote endothelialization on a bare metal CoCr alloy stent still widely used nowadays. The knowledge about biological response and interactions between extra cellular matrix proteins and cellular agents has lead to explore the potential of genetically engineered protein based polymers such as elastin-like polymers which mimic properties of the human elastin. This project has for general goal to promote endothelialization on CoCr-alloy by functionalizing the surfaces with REDV elastin-like biopolymer which contains a specific domain for endothelial cell adhesion. For that purpose different surface treatments have been performed on CoCr in order to enhance the biopolymer adhesion. First surfaces have been activated by means of O2 plasma, acid HNO3 and NaOH basic etching. Afterwards, a series has been CPTES silanized previous to biopolymer adsorption. Finally, REDV elastin-like biopolymer has been physically and/or chemically attached to the different treated surfaces. All treatments have been thoroughly physic-chemically characterized before and after all treatments steps. Finally special attention has been paid to the study of biopolymer coating stability after some thermal and/or mechanical treatments in order to determine the best surface treatment conditions of adhesion and the efficiency of previous surface treatments. REDV elastin-like biopolymer was successfully adsorbed on CoCr ASTM F-90 alloy surfaces. It was biofunctionalized CoCr ASTM F-90 alloy surfaces through CPTES silane. Silanization increased biopolymer adsorption but the efficiency was low. NaOH activated samples presented a higher CPTES silane attachment and biopolymer adhesion as observed by an increase of adhered HUVEC cells compared to other treatments. REDV elastin-like biopolymer is more sensitive to mechanical and thermal treatments probably due to a detachment and/or denaturation of the biomolecule. The increase of silanization efficiency on treated CoCr surfaces could enhance biopolymer stability as observed for NaOH treated surfaces.

Science and Principles of Biodegradable and Bioresorbable Medical Polymers

Science and Principles of Biodegradable and Bioresorbable Medical Polymers Book
Author : Xiang Cheng Zhang
Publisher : Woodhead Publishing
Release : 2016-09-22
ISBN : 0081003935
Language : En, Es, Fr & De

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Book Description :

Science and Principles of Biodegradable and Bioresorbable Medical Polymers: Materials and Properties provides a practical guide to the use of biodegradable and bioresorbable polymers for study, research, and applications within medicine. Fundamentals of the basic principles and science behind the use of biodegradable polymers in advanced research and in medical and pharmaceutical applications are presented, as are important new concepts and principles covering materials, properties, and computer modeling, providing the reader with useful tools that will aid their own research, product design, and development. Supported by practical application examples, the scope and contents of the book provide researchers with an important reference and knowledge-based educational and training aid on the basics and fundamentals of these important medical polymers. Provides a practical guide to the fundamentals, synthesis, and processing of bioresorbable polymers in medicine Contains comprehensive coverage of material properties, including unique insights into modeling degradation Written by an eclectic mix of international authors with experience in academia and industry

Functionalized CoCr Surfaces with Adhesive Molecules to Improve Endothelialization

Functionalized CoCr Surfaces with Adhesive Molecules to Improve Endothelialization Book
Author : Maria Isabel Castellanos Arboleda
Publisher : Unknown
Release : 2017
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Cobalt-chromium (CoCr) alloys are widely used as biomaterials for coronary stents due to their excellent mechanical properties, biocompatibility and corrosion resistance. However, these materials are bioinert, retarding the complete endothelialization and resulting in a higher risk of restenosis, narrowing of the artery, and late-stent thrombosis. Therefore, the improvement of implants surface endothelialization has acquired importance in the last years. Immobilization of cell adhesive biomolecules onto biomaterials surface is a well-known strategy to control cell response. However, the strategy of immobilization, the optimal combination or the appropriate spatial presentation of the bioactive sequences to enhance endothelialization for cardiovascular applications, remains to be elucidated. The present PhD thesis focused on the development of a new biofunctionalized CoCr alloy surfaces in order to improve the endothelialization. To that end, elastin-like recombinamers (ELR) genetically modified with an REDV (Arg-Glu-Asp-Val) sequence and short synthetized peptides RGDS (Arg-Gly-Asp-Ser), REDV, YIGSR (Tyr-Ile-Gly-Ser-Arg) and their equimolar combination, were attached by physisorption and covalent bonding onto CoCr alloy surfaces and thoroughly characterized physico-chemically and evaluated in vitro with human umbilical vein endothelial cells (HUVECs), coronary artery smooth muscle cells (CASMCs) and platelets from blood donors. First, biofunctionalized surfaces with ELR were developed and optimized by evaluating different surface activation treatments, oxygen plasma and sodium hydroxide etching, and different binding strategies, physisorption and covalent bonding. The functionalized surfaces demonstrated a higher cell adhesion and spreading of HUVEC cells, this effect is emphasized as increases the amount of immobilized biomolecules and directly related to the immobilization technique: covalent bonding. Nevertheless, the silanization process was not completely effective since a mixture of covalent and physisorption behavior was observed probably due to the use of big molecules that decreased the control of the bonding between the biomolecule and the surface. Secondly, it was synthetized immobilized RGDS, REDV, YIGSR and their equimolar combination peptides onto the different surfaces. Cell studies demonstrated that the covalent functionalization of CoCr surfaces with an equimolar combination of RGDS/YIGSR represented the most powerful strategy to enhance the early stages of HUVECs adhesion, proliferation and migration, indicating a positive synergistic effect between the two peptide motifs. Besides, gene expression and platelet adhesion studies showed that surfaces silanized with the combination RGDS/YIGSR improved anti-thrombogenicity compared to non-modified surfaces. Finally, cell co-cultures of HUVECs/CASMCs found that functionalization increased the amount of adhered HUVECs onto modified surfaces compared to plain CoCr, independently of the used peptide and the strategy of immobilization. Overall, the present thesis offer a comprehensive view of the effectiveness of immobilizing cell adhesive molecules onto CoCr alloy surfaces to enhance endothelialization while preventing restenosis and thrombosis for cardiovascular applications.

Concise Concepts of Nanoscience and Nanomaterials

Concise Concepts of Nanoscience and Nanomaterials Book
Author : N. Kumar,S. Kumbhat
Publisher : Scientific Publishers
Release : 2018-08-01
ISBN : 938817206X
Language : En, Es, Fr & De

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Book Description :

This book provides a basic understanding of the emerging multidisciplinary area of nanoscience and nanomaterials being offered as core subjects both in basic sciences and engineering disciplines at graduate and postgraduate levels. The subject matter of the book is designed to generate a clear understanding on various aspects of nanoscience from fundamentals to technological applications along with the exhaustive account of nanomaterials classified in a very appropriate manner. Book includes a balanced view on the physics to understand the origin of unique properties of nanomaterials and well tested synthetic techniques including simple chemical and physical routes illustrated with examples. Special emphasis is given on the characterization techniques for nanomaterials in terms of spectroscopy, scattering phenomena and microscopy including their principle, methodology and data interpretation illustrated with examples. I order to drive on the significance of nanoscience and nanomaterials; impact of nanotechnology in diverse area such as health care, environment protection, agriculture, energy, security has been dealt separately. The historical perspective as well existence of nanomaterials in nature both in living and nonliving species has also been discussed in the beginning. It is hoped that the book will prove to be student centric at all levels, from different disciplines to understand the revolutionary as well as evolutionary field of nanoscience. Further, book will also be a valuable resource for professionals, researchers and others interested to gain understanding of the principles of nanoscience and benefits of nanomaterials in developing newer technology.

Polyurethane Polymers Composites and Nanocomposites

Polyurethane Polymers  Composites and Nanocomposites Book
Author : Sabu Thomas,Janusz Datta,Jozef Haponiuk,Arunima Reghunadhan
Publisher : Elsevier
Release : 2017-08-17
ISBN : 0128041021
Language : En, Es, Fr & De

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Book Description :

Polyurethane Polymers: Composites and Nanocomposites concentrates on the composites and nanocomposites of polyurethane based materials. Polyurethane composites are a very important class of materials widely used in the biomedical and industrial field that offer numerous potential applications in many areas. This book discusses current research and identifies future research needs in the area. Provides an elaborate coverage of the chemistry of polyurethane, its synthesis, and properties Includes available characterization techniques Relates types of polyurethanes to their potential properties Discusses composites, nanocomposites options, and PU recycling

Encyclopedia of Polymer Applications 3 Volume Set

Encyclopedia of Polymer Applications  3 Volume Set Book
Author : Munmaya Mishra
Publisher : CRC Press
Release : 2018-12-17
ISBN : 1351019414
Language : En, Es, Fr & De

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Book Description :

Undoubtedly the applications of polymers are rapidly evolving. Technology is continually changing and quickly advancing as polymers are needed to solve a variety of day-to-day challenges leading to improvements in quality of life. The Encyclopedia of Polymer Applications presents state-of-the-art research and development on the applications of polymers. This groundbreaking work provides important overviews to help stimulate further advancements in all areas of polymers. This comprehensive multi-volume reference includes articles contributed from a diverse and global team of renowned researchers. It offers a broad-based perspective on a multitude of topics in a variety of applications, as well as detailed research information, figures, tables, illustrations, and references. The encyclopedia provides introductions, classifications, properties, selection, types, technologies, shelf-life, recycling, testing and applications for each of the entries where applicable. It features critical content for both novices and experts including, engineers, scientists (polymer scientists, materials scientists, biomedical engineers, macromolecular chemists), researchers, and students, as well as interested readers in academia, industry, and research institutions.

Proceedings of 19th World Congress on Materials Science and Engineering 2018

Proceedings of 19th World Congress on Materials Science and Engineering 2018 Book
Author : ConferenceSeries
Publisher : ConferenceSeries
Release : 2021-10-19
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

June 11-13, 2018 Barcelona, Spain Key Topics : Materials Science and Engineering, Nanomaterials and Nanotechnology, Biomaterials and Medical Devices, Polymer Science and Technology, Ceramics and Composite Materials, Electronic, Optical and Magnetic Materials, Emerging Smart Materials, Materials for Energy and Environmental Sustainability, Physics and Chemistry of Materials, Metals, Mining, Metallurgy and Materials, Mechanics, Characterization Techniques and Equipments, Graphene and 2D Materials,

Biomedical Application of Nanoparticles

Biomedical Application of Nanoparticles Book
Author : Bertrand Henri Rihn
Publisher : CRC Press
Release : 2017-09-05
ISBN : 1498750028
Language : En, Es, Fr & De

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Book Description :

Biomedical Application of Nanoparticles explores nanoparticles, their chemical and physicals properties, and how they interact in biological systems with proteins, immune system and targeted cells. Risk assessment of nanoparticles for human is described, including: cellular paradigms, transcriptomics and toxicogenomics. Finally, the applications of nanoparticles in medicine and antioxidant regenerative therapeutics are presented in several chapters with emphasis on how nanoparticles enhance transport of drugs across biological membrane barriers and therefore may enhance drug bioavailability.

Recent Advances in Mechanical Engineering

Recent Advances in Mechanical Engineering Book
Author : Anil Kumar
Publisher : Springer Nature
Release : 2021-10-19
ISBN : 9811596786
Language : En, Es, Fr & De

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Book Description :

Download Recent Advances in Mechanical Engineering book written by Anil Kumar, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Surface Engineering of Polymeric Biomaterials

Surface Engineering of Polymeric Biomaterials Book
Author : Todorka G Vladkova
Publisher : Smithers Rapra
Release : 2013-01-10
ISBN : 1847356605
Language : En, Es, Fr & De

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Book Description :

Biomaterials work in contact with living matter and this gives a number of specific requirements for their surface properties, such as bioinertness or bioactivity, antibiofouling, and so on. Surface engineering based on physical, chemical, physical-chemical, biochemical or biological principles is important for the preparation of biomaterials with the desired biocontact properties. This book helps the reader gain the knowledge to enable them to work in such a rapidly developing area, with a comprehensive list of references given for each chapter. Strategies for tailoring the biological response through the creation of biomaterial surfaces resistant to fouling are discussed. Methods of eliciting specific biomolecular interactions that can be further combined with patterning techniques to engineer adhesive areas in a noninteractive background are also covered. The theoretical basis of surface engineering for improvement of biocontact properties of polymeric biomaterials as well as the current state-of-the-art of the surface engineering of polymeric biomaterials are presented. The book also includes information on the most used conventional and advanced surface engineering methods. The book is targeted at researchers, post-doctorates, graduate students, and those already working in the field of biomaterials with a special interest in the creation of polymeric materials with improved biocontact properties via surface engineering.

Carbon Nanotubes

Carbon Nanotubes Book
Author : Silvana Fiorito
Publisher : CRC Press
Release : 2019-04-30
ISBN : 9814241148
Language : En, Es, Fr & De

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Book Description :

The field of C-nanoparticles toxicity is, at present, fragmented and contradictory, oscillating between enthusiastic raptures and bitter disappointments. This important book presents an overall, unitary view of the carbon nanoparticle world, in which both the positive and negative aspects of these recently discovered nanomaterials are critically de

Monitoring Drug Loading and Releasing in MIL 88B Fe Films Modified Gold Substrates Using Surface Plasmon Methods

Monitoring Drug Loading and Releasing in MIL 88B Fe  Films Modified Gold Substrates Using Surface Plasmon Methods Book
Author : Trenton Nguyen
Publisher : Unknown
Release : 2017
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

A large portion of patients experience coronary artery disease (CAD) caused by atherosclerosis. One of the treatments of CAD is to utilize stents to restore blood flow. Compared to traditional bare metal stents (BMS), polymer-based drug eluting stents (DES) can minimize restenosis symptoms, however they may cause late-stent thrombosis. A significant amount of effort has been devoted to design polymer-free stent by introducing biodegradable drug eluting materials, such as metal-organic framework (MOF). MOFs are composed of repeating units of metal ions connected by organic linkers by forming porous three-dimensional structures. Known for their high surface area and versatile properties, selective MOFs show great potential applications in drug delivery systems. Certain MOFs have exhibited prominent results through their high drug capacity, uniform topography, and flexible structures. Our research investigated iron-based MIL-88B, a type of MOF, as a drug delivery system with ibuprofen as a model drug. We studied ibuprofen encapsulation and delivering properties on MIL-88B(Fe) films attached on a chemically functionalized Au surface. MIL-88B(Fe) film was prepared through a direct crystallization method using the mother solution from solvothermal synthesis. The film was implemented on an Au surface with a COOH-terminated self-assembled monolayer (SAM). Surface plasmon resonance (SPR) was used to monitor the drug loading and kinetic eluting behaviors on MIL-88B(Fe) films.

Implantable Sensor Systems for Medical Applications

Implantable Sensor Systems for Medical Applications Book
Author : Andreas Inmann,Diana Hodgins
Publisher : Elsevier
Release : 2013-01-02
ISBN : 0857096281
Language : En, Es, Fr & De

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Book Description :

Implantable sensor systems offer great potential for enhanced medical care and improved quality of life, consequently leading to major investment in this exciting field. Implantable sensor systems for medical applications provides a wide-ranging overview of the core technologies, key challenges and main issues related to the development and use of these devices in a diverse range of medical applications. Part one reviews the fundamentals of implantable systems, including materials and material-tissue interfaces, packaging and coatings, microassembly, electrode array design and fabrication, and the use of biofuel cells as sustainable power sources. Part two goes on to consider the challenges associated with implantable systems. Biocompatibility, sterilization considerations and the development of active implantable medical devices in a regulated environment are discussed, along with issues regarding data protection and patient privacy in medical sensor networks. Applications of implantable systems are then discussed in part three, beginning with Microelectromechanical systems (MEMS) for in-vivo applications before further exploration of tripolar interfaces for neural recording, sensors for motor neuroprostheses, implantable wireless body area networks and retina implants. With its distinguished editors and international team of expert contributors, Implantable sensor systems for medical applications is a comprehensive guide for all those involved in the design, development and application of these life-changing technologies. Provides a wide-ranging overview of the core technologies, key challenges and main issues related to the development and use of implantable sensor systems in a range of medical applications Reviews the fundamentals of implantable systems, including materials and material-tissue interfaces, packaging and coatings, and microassembly Considers the challenges associated with implantable systems, including biocompatibility and sterilization