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From Molecules To Networks

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From Molecules to Networks

From Molecules to Networks Book
Author : Ruth Heidelberger,M. Neal Waxham,John H. Byrne,James L. Roberts
Publisher : Academic Press
Release : 2009-01-27
ISBN : 9780080920832
Language : En, Es, Fr & De

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Book Description :

An understanding of the nervous system at virtually any level of analysis requires an understanding of its basic building block, the neuron. From Molecules to Networks provides the solid foundation of the morphologic, biochemical, and biophysical properties of nerve cells. All chapters have been thoroughly revised for this second edition to reflect the significant advances of the past 5 years. The new edition expands on the network aspects of cellular neurobiology by adding a new chapter, Information Processing in Neural Networks, and on the relation of cell biological processes to various neurological diseases. The new concluding chapter illustrates how the great strides in understanding the biochemical and biophysical properties of nerve cells have led to fundamental insights into important aspects of neurodegenerative disease. • Written and edited by leading experts in the field, the second edition completely and comprehensively updates all chapters of this unique textbook • Discusses emerging new understanding of non-classical molecules that affect neuronal signaling • Full colour, professional graphics throughout • Includes two new chapters: Information Processing in Neural Networks - describes the principles of operation of neural networks and the key circuit motifs that are common to many networks in the nervous system. Molecular and Cellular Mechanisms of Neurodegenerative Disease - introduces the progress made in the last 20 years in elucidating the cellular and molecular mechanisms underlying brain disorders, including Amyotrophic Lateral Sclerosis (ALS), Parkinson disease, and Alzheimer’s disease.

From Molecules to Networks

From Molecules to Networks Book
Author : John H. Byrne,Ruth Heidelberger,M. Neal Waxham
Publisher : Academic Press
Release : 2014-05-23
ISBN : 0123982677
Language : En, Es, Fr & De

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Book Description :

An understanding of the nervous system at virtually any level of analysis requires an understanding of its basic building block, the neuron. The third edition of From Molecules to Networks provides the solid foundation of the morphological, biochemical, and biophysical properties of nerve cells. In keeping with previous editions, the unique content focus on cellular and molecular neurobiology and related computational neuroscience is maintained and enhanced. All chapters have been thoroughly revised for this third edition to reflect the significant advances of the past five years. The new edition expands on the network aspects of cellular neurobiology by adding new coverage of specific research methods (e.g., patch-clamp electrophysiology, including applications for ion channel function and transmitter release; ligand binding; structural methods such as x-ray crystallography). Written and edited by leading experts in the field, the third edition completely and comprehensively updates all chapters of this unique textbook and insures that all references to primary research represent the latest results. The first treatment of cellular and molecular neuroscience that includes an introduction to mathematical modeling and simulation approaches 80% updated and new content New Chapter on "Biophysics of Voltage-Gated Ion Channels" New Chapter on "Synaptic Plasticity" Includes a chapter on the Neurobiology of Disease Highly referenced, comprehensive and quantitative Full color, professional graphics throughout All graphics are available in electronic version for teaching purposes

From Molecules to Networks

From Molecules to Networks Book
Author : John H. Byrne,James Lewis Roberts
Publisher : Academic Press
Release : 2004
ISBN : 9780121486600
Language : En, Es, Fr & De

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Book Description :

An understanding of the nervous system at virtually any level of analysis requires an understanding of its basic building block, the neuron. This book provides the solid foundation of the morphological, biochemical, and biophysical properties of nerve cells that is needed by advanced undergraduates and graduate students, as well as researchers in need of a thorough reference. * Highly referenced for readers to pursue topics of interest in greater detail * Unique coverage of the application of mathematical modeling and simulation approaches not found in other textbooks * Richly illustrated, four color presentation throughout * Includes CD-ROM of all of the illustrations

Cellular and Molecular Neurophysiology

Cellular and Molecular Neurophysiology Book
Author : Constance Hammond
Publisher : Academic Press
Release : 2014-12-30
ISBN : 0123973228
Language : En, Es, Fr & De

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Book Description :

Cellular and Molecular Neurophysiology, Fourth Edition, is the only up-to-date textbook on the market that focuses on the molecular and cellular physiology of neurons and synapses. Hypothesis-driven rather than a dry presentation of the facts, the book promotes a real understanding of the function of nerve cells that is useful for practicing neurophysiologists and students in a graduate-level course on the topic alike. This new edition explains the molecular properties and functions of excitable cells in detail and teaches students how to construct and conduct intelligent research experiments. The content is firmly based on numerous experiments performed by top experts in the field This book will be a useful resource for neurophysiologists, neurobiologists, neurologists, and students taking graduate-level courses on neurophysiology. 70% new or updated material in full color throughout, with more than 350 carefully selected and constructed illustrations Fifteen appendices describing neurobiological techniques are interspersed in the text

Bacterial Molecular Networks

Bacterial Molecular Networks Book
Author : Jacques van Helden,Ariane Toussaint,Denis Thieffry
Publisher : Humana Press
Release : 2011-12-08
ISBN : 9781617793608
Language : En, Es, Fr & De

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Book Description :

Network-based representations have become pervasive in most fields in biology. Bacterial Molecular Networks: Methods and Protocols provides authoritative descriptions of various experimental and computational methods enabling the characterization and analysis of molecular interaction networks, with a focus on bacteria. Divided into three convenient sections, this volume provides extensive coverage of various experimental and in silico approaches aiming at the characterization of network components, addresses the presentation of computational approaches to analyze the topology of molecular networks, and further introduces a variety of methods and tools enabling scientists to generate qualitative or quantitative dynamical models of molecular processes in bacteria. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and accessible, Bacterial Molecular Networks: Methods and Protocols is intended primarily for post-graduate students and researchers working in the field of experimental and computational microbiology and provides a combination of up-to-date reviews along with detailed protocols written by the developers of bioinformatics resources, such as databases and software tools.

Molecular Diagnostics and Treatment of Pancreatic Cancer

Molecular Diagnostics and Treatment of Pancreatic Cancer Book
Author : Asfar Azmi
Publisher : Elsevier
Release : 2014-04-14
ISBN : 0124079466
Language : En, Es, Fr & De

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Book Description :

Molecular Diagnostics and Treatment of Pancreatic Cancer describes the different emerging applications of systems biology and how it is shaping modern pancreatic cancer research. This book begins by introducing the current state of the art knowledge, trends in diagnostics, progress in disease model systems as well as new treatment and palliative care strategies in pancreatic cancer. Specific sections are dedicated to enlighten the readers to newer discoveries that have emerged from gene expression profiling, proteomics, metabolomics and systems level analyses of pancreatic cancer datasets. First of a kind and novel network strategies to understand oncogenic Kras signaling in pancreatic tumors are presented. The attempts to computationally model and prioritize microRNAs that cause pancreatic cancer resistance are also highlighted. Addressing this important area, Molecular Diagnostics and Treatment of Pancreatic Cancer provides insights into important network evaluation methodologies related to pancreatic cancer related microRNAs targetome. There are dedicated chapters on critical aspects of the evolving yet controversial field of pancreatic cancer stems cells. The work concludes by discussing the applications of network sciences in pancreatic cancer drug discovery and clinical trial design. Encompasses discussion of innovative tools including expression signatures in cell lines, 3D models, animal xenograft models, primary models and patient derived samples, aiding subversion of traditional biology paradigms, and enhancing comprehension across conventional length and temporal scales Coverage includes novel applications in targeted drugs, polypharmacology, network pharmacology and other related drug development arenas – helping researchers in pancreatic cancer drug discovery Summarizes many relevant computational and clinical references from fast-evolving literature Comprehensive glossary helps newer readers understand technical terms and specialized nomenclature

Molecular Neuroscience

Molecular Neuroscience Book
Author : Patricia Revest,Alan Longstaff
Publisher : Garland Science
Release : 1998
ISBN : 1859962505
Language : En, Es, Fr & De

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Book Description :

Molecular Neuroscience takes an interesting and original approach to explaining the present and future impact of molecular biology on the study of neuroscience. It provides the reader with a level of understanding which will allow them to delve deeper into the ever expanding neuroscience literature. A good balance is achieved between a didactic style and well-selected examples of experimental approaches. This book is written for 2nd and 3rd year life science undergraduates and MSc students on a range of courses. Medical students and researchers requiring a concise introduction to neuroscience, particularly the latest molecular approaches, will also find it an essential read.

Contemporary Approaches to the Study of Pain

Contemporary Approaches to the Study of Pain Book
Author : Rebecca Seal
Publisher : Humana
Release : 2022-05-19
ISBN : 9781071620380
Language : En, Es, Fr & De

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Book Description :

This volume contains experimental approaches that are currently revolutionizing our understanding of the neurobiology of pain. The chapters cover many cutting-edge methods including the identification of gene expression profiles, transcriptomes or translatomes, from individual cells or defined groups of cells in rodents and primates; the electrophysiological investigation of human tissues, such as human dorsal root ganglion neurons; ways to assess modality response profiles of neurons using calcium imaging in vitro and in vivo; and somatosensory behaviors in rodents using high-speed videography and machine learning. In the Neuromethods series style, the chapters include detailed advice from specialists to obtain successful results in your laboratory. Cutting-edge and comprehensive, Contemporary Approaches to the Study of Pain: From Molecules to Neural Networks is a valuable resource for scientists and researchers interested in making impactful contributions to our understanding of pain.

Stress From Molecules to Behavior

Stress   From Molecules to Behavior Book
Author : Hermona Soreq,Alon Friedman,Daniela Kaufer
Publisher : John Wiley & Sons
Release : 2009-10-06
ISBN : 3527628355
Language : En, Es, Fr & De

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Book Description :

This title comprehensively covers the molecular basis of stress responses of the nervous system, providing a unique and fundamental insight into the molecular, physiological and behavioral basis of the stress response of a whole organism. Edited by leading experts in the field and summarizing the latest research advances in this area, this ready reference is an invaluable resource for clinicians dealing with stress-related disorders, biomedical researchers working in the field as well as for pharmacology and biotech companies.

Rheological Equations from Molecular Network Theories

Rheological Equations from Molecular Network Theories Book
Author : Pierre Jean Carreau
Publisher : Unknown
Release : 1968
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Rheological Equations from Molecular Network Theories book written by Pierre Jean Carreau, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Molecular Evolutionary Models in Drug Discovery

Molecular Evolutionary Models in Drug Discovery Book
Author : Juan Bueno
Publisher : Academic Press
Release : 2020-01-22
ISBN : 0128189290
Language : En, Es, Fr & De

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Book Description :

Molecular Evolutionary Models in Drug Discovery explores the application of evolutionary molecular models in drug discovery in which secondary metabolites play a fundamental role. Secondary metabolites are not produced in isolation, they are the result of the interaction of genes, metabolism and the environment. The book examines the role of secondary metabolites as leads in drug discovery and on the development of a rational bioprospecting model for new medicines based on the evolution of secondary metabolism. These evolutionary models are part of biological systems and are the most reliable expression of the functioning of living beings. Examines the integration and application of evolutionary models in the pharmaceutical industry to create new drug development platforms Investigates the biotechnological prospecting of secondary metabolites and their potential use in the discovery of new drugs Evaluates the ecosystem of living beings and how its molecular adaptation might improve the success of therapies

Molecular Gels

Molecular Gels Book
Author : Richard G. Weiss,Pierre Terech
Publisher : Springer Science & Business Media
Release : 2006-06-30
ISBN : 1402036892
Language : En, Es, Fr & De

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Book Description :

"Molecular Gels: Materials with Self-Assembled Fibrillar Networks" is a comprehensive treatise on gelators, especially low molecular-mass gelators and the properties of their gels. The structures and modes of formation of the self-assembled fibrillar networks (SAFINs) that immobilize the liquid components of the gels are discussed experimentally and theoretically. The spectroscopic, rheological, and structural features of the different classes of low molecular-mass gelators are also presented. Many examples of the application of the principal analytical techniques for investigation of molecular gels (including SANS, SAXS, WAXS, UV-vis absorption, fluorescence and CD spectroscopies, scanning electron, transmission electron and optical microscopies, and molecular modeling) are presented didactically and in-depth, as are several of the theories of the stages of aggregation of individual low molecular-mass gelator molecules leading to SAFINs. Several actual and potential applications of molecular gels in disparate fields (from silicate replication of nanostructures to art conservation) are described. Special emphasis is placed on perspectives for future developments. This book is an invaluable resource for researchers and practitioners either already researching self-assembly and soft matter or new to the area. Those who will find the book useful include chemists, engineers, spectroscopists, physicists, biologists, theoreticians, and materials scientists.

Bioanalytics

Bioanalytics Book
Author : Friedrich Lottspeich,Joachim W. Engels
Publisher : John Wiley & Sons
Release : 2018-03-08
ISBN : 3527694463
Language : En, Es, Fr & De

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Book Description :

Analytical methods are the essential enabling tools of the modern biosciences. This book presents a comprehensive introduction into these analytical methods, including their physical and chemical backgrounds, as well as a discussion of the strengths and weakness of each method. It covers all major techniques for the determination and experimental analysis of biological macromolecules, including proteins, carbohydrates, lipids and nucleic acids. The presentation includes frequent cross-references in order to highlight the many connections between different techniques. The book provides a bird's eye view of the entire subject and enables the reader to select the most appropriate method for any given bioanalytical challenge. This makes the book a handy resource for students and researchers in setting up and evaluating experimental research. The depth of the analysis and the comprehensive nature of the coverage mean that there is also a great deal of new material, even for experienced experimentalists. The following techniques are covered in detail: - Purification and determination of proteins - Measuring enzymatic activity - Microcalorimetry - Immunoassays, affinity chromatography and other immunological methods - Cross-linking, cleavage, and chemical modification of proteins - Light microscopy, electron microscopy and atomic force microscopy - Chromatographic and electrophoretic techniques - Protein sequence and composition analysis - Mass spectrometry methods - Measuring protein-protein interactions - Biosensors - NMR and EPR of biomolecules - Electron microscopy and X-ray structure analysis - Carbohydrate and lipid analysis - Analysis of posttranslational modifications - Isolation and determination of nucleic acids - DNA hybridization techniques - Polymerase chain reaction techniques - Protein sequence and composition analysis - DNA sequence and epigenetic modification analysis - Analysis of protein-nucleic acid interactions - Analysis of sequence data - Proteomics, metabolomics, peptidomics and toponomics - Chemical biology

Functional Coherence of Molecular Networks in Bioinformatics

Functional Coherence of Molecular Networks in Bioinformatics Book
Author : Mehmet Koyutürk,Shankar Subramaniam,Ananth Grama
Publisher : Springer Science & Business Media
Release : 2011-09-22
ISBN : 9781461403203
Language : En, Es, Fr & De

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Book Description :

Molecular networks provide descriptions of the organization of various biological processes, including cellular signaling, metabolism, and genetic regulation. Knowledge on molecular networks is commonly used for systems level analysis of biological function; research and method development in this area has grown tremendously in the past few years. This book will provide a detailed review of existing knowledge on the functional characterization of biological networks. In 15 chapters authored by an international group of prolific systems biology and bioinformatics researchers, it will organize, conceptualize, and summarize the existing core of research results and computational methods on understanding biological function from a network perspective.

Artificial Neural Networks

Artificial Neural Networks Book
Author : David J. Livingstone
Publisher : Humana Press
Release : 2011-10-09
ISBN : 9781617377389
Language : En, Es, Fr & De

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Book Description :

In this book, international experts report the history of the application of ANN to chemical and biological problems, provide a guide to network architectures, training and the extraction of rules from trained networks, and cover many cutting-edge examples of the application of ANN to chemistry and biology. Methods involving the mapping and interpretation of Infra Red spectra and modelling environmental toxicology are included. This book is an excellent guide to this exciting field.

From Molecules to Minds

From Molecules to Minds Book
Author : Institute of Medicine,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders
Publisher : National Academies Press
Release : 2008-11-07
ISBN : 9780309178457
Language : En, Es, Fr & De

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Book Description :

Neuroscience has made phenomenal advances over the past 50 years and the pace of discovery continues to accelerate. On June 25, 2008, the Institute of Medicine (IOM) Forum on Neuroscience and Nervous System Disorders hosted more than 70 of the leading neuroscientists in the world, for a workshop titled "From Molecules to Minds: Challenges for the 21st Century." The objective of the workshop was to explore a set of common goals or "Grand Challenges" posed by participants that could inspire and rally both the scientific community and the public to consider the possibilities for neuroscience in the 21st century. The progress of the past in combination with new tools and techniques, such as neuroimaging and molecular biology, has positioned neuroscience on the cusp of even greater transformational progress in our understanding of the brain and how its inner workings result in mental activity. This workshop summary highlights the important issues and challenges facing the field of neuroscience as presented to those in attendance at the workshop, as well as the subsequent discussion that resulted. As a result, three overarching Grand Challenges emerged: How does the brain work and produce mental activity? How does physical activity in the brain give rise to thought, emotion, and behavior? How does the interplay of biology and experience shape our brains and make us who we are today? How do we keep our brains healthy? How do we protect, restore, or enhance the functioning of our brains as we age?

The Nature of the Mechanical Bond

The Nature of the Mechanical Bond Book
Author : Carson J. Bruns,J. Fraser Stoddart
Publisher : John Wiley & Sons
Release : 2016-11-07
ISBN : 1119044006
Language : En, Es, Fr & De

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Book Description :

An introduction to the mechanical bond -- The fundamentals of making mechanical bonds -- Making mechanical bonds under thermodynamic control -- Molecular topologies and architectures with mechanical bonds -- The stereochemistry of the mechanical bond -- Molecular switches and machines with mechanical bonds

Creating the Molecules of Life

Creating the Molecules of Life Book
Author : Dr Richard N. Boyd,Dr Michael a. Famiano
Publisher : Iph001
Release : 2018-10-22
ISBN : 9780750319911
Language : En, Es, Fr & De

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Book Description :

Creating the Molecules of Life discusses origins, including the Big Bang, and the origin of the elements. With a complete presentation and explanation, this book provides evidence that the molecules of life are produced in outer space and how the SNAAP model purports to explain that origin. Extremophiles, which explains that evolution is robust enough to create life forms in a wide variety of conditions, is also presented. Readable for those at the upper undergraduate level, mathematics associated with coupling the nuclear spins to the molecular chirality is discussed. An accompanied appendix is provided to support mathematics.

Molecular Biology of the Cell

Molecular Biology of the Cell Book
Author : Bruce Alberts
Publisher : Unknown
Release : 2004
ISBN : 9780815332183
Language : En, Es, Fr & De

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Book Description :

Download Molecular Biology of the Cell book written by Bruce Alberts, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.