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From Artemisia Annua L To Artemisinins

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From Artemisia annua L to Artemisinins

From Artemisia annua L  to Artemisinins Book
Author : Youyou Tu
Publisher : Academic Press
Release : 2017-07-08
ISBN : 0128116560
Language : En, Es, Fr & De

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Book Description :

From Artemisia annua L. to Artemisinins: The Discovery and Development of Artemisinins and Antimalarial Agents is the first book that systematically introduces the origin and development of artemisinine and artemisinine-based drugs. It includes four distinct sections, including Artemisia annua L., Artemisinin, Dihydroartemisinin, and other artemisinin derivatives. Tu Youyou, the chief inventor of artemisinin, together with other members from the research team, have written a book that will be a valuable reference work for both researchers involved in the medical industry and scholars who are interested in undertaking innovative research. Presents a full view of artemisinin, not only its origin and development, but also chemical structure, chemical properties, extracting mode, derivatives, chromogenic reaction, general pharmacological, and toxicology. Provides many aspects of artemisinin-based drugs Incudes lots of experimental data, such as the X-ray crystallography result—the first application reported in China in determining the absolute molecular configuration utilizing the scattering effects of oxygen atoms by X-ray diffraction technique

Extraction of Artemisinin from Artemisia Annua

Extraction of Artemisinin from Artemisia Annua Book
Author : Seid Yimer
Publisher : GRIN Verlag
Release : 2013-01-28
ISBN : 3656361665
Language : En, Es, Fr & De

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Book Description :

Bachelor Thesis from the year 2008 in the subject Engineering - Chemical Engineering, grade: A, Bahir Dar University (Bahir Dar University Engineering Faculity), course: Chemical Engineering, language: English, abstract: Abstract Malaria disease is endemic in least developed countries like Ethiopia. The rapid development of drug-resistant malaria parasite strain leaves the need for new effective anti-malarial drugs. Artemisinin is a sesquiterpene lactone found in the leaves and flowers of plants Artemisia annua L and have different chemical structures and higher efficacy than others. The content of artemisinin is very small and from 0.5 to 1.2 % of dry weight of plants in Ethiopia. Extraction of artemisinin from Artemisia annua is mainly performed using hydrocarbon extraction processes. Extraction with Supercritical CO2, ethanol, ionic liquids, hydroflourocarbon HFC-134a and hexane extraction are extraction technologies and compared majorly in terms of their extraction efficiency, cost and drawback to environment. Since artemisinin is only present in the epidermis of the leaves, leaves were only washed on the outside by stirring appeared to be the most appropriate method and the first step in this research was solvent extraction using hexane. Step followed purify by repeated crystallization. Laboratory scale production data and procedures were listed for aremisinin extraction process. By using those data large scale production method was designed. And did material and energy balance calculations for large scale production process carried out by taking scientific approach followed by feasibility study. As a result my extractor was very large and it has 14.37m3 capacities it wasn’t found in market. So I designed the required larger extractor that should fulfill the target of the project i.e. with simple, rapid, cost effective, environmental friendly and practical method for the isolation of artemisinin from Artemisia annua. The design the extractor I used the optimum ratio between solvent and leaves, optimum extraction time, optimum extraction temperature and optimum design of the stirrer paddles. In these thesis work extractor design, skirt design, bolt design, reinforcement calculations, preliminary equipment design (sizing), economic analysis calculations were included. In the profitability analysis Return on investment, payback period and net present worth calculated and the project was checked its feasibility. The payback period is 1.22yrs and it is economically acceptable that means this market is promising in Ethiopia in addition to save millions of Ethiopian and African from killer malaria. Key words: artemisinin, sesquiterpene lactone, hexane extraction

Selection of Artemisia Annua L Cell Lines for Production of Cell Biomass Artemisinin and Dihydroartemisinin

Selection of Artemisia Annua L  Cell Lines for Production of Cell Biomass  Artemisinin and Dihydroartemisinin Book
Author : Song Jin Ch'ng
Publisher : Unknown
Release : 2014
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Selection of Artemisia Annua L Cell Lines for Production of Cell Biomass Artemisinin and Dihydroartemisinin book written by Song Jin Ch'ng, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Artemisia annua Pharmacology and Biotechnology

Artemisia annua   Pharmacology and Biotechnology Book
Author : Tariq Aftab,Jorge F.S. Ferreira,M. Masroor A. Khan,M. Naeem
Publisher : Springer
Release : 2013-12-11
ISBN : 9783642410260
Language : En, Es, Fr & De

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Book Description :

Artemisinin, a sesquiterpene lactone originally extracted from the medicinal plant Artemisia annua L., is an effective antimalarial agent, particularly for multi-drug resistant and cerebral malaria. However, the concentration of artemisinin in the plant is very low. Because the chemical synthesis of artemisinin is complicated and not economically feasible in view of the poor yield of the drug, the intact plant remains the only viable source of artemisinin production. Therefore, it is necessary to increase the concentration of artemisinin in A. annua to reduce the cost of artemisinin based antimalarial drugs. Plant scientists have focused their efforts on A. annua for a higher artemisinin crop yield. With the present volume, we are bringing together the research which is being done on this plant throughout the world and future possibilities for scientists and researchers who want to work on it.

Regulation of Artemisinin Biosynthesis in Artemisia Annua L

Regulation of Artemisinin Biosynthesis in Artemisia Annua L  Book
Author : Anonim
Publisher : Unknown
Release : 2014
ISBN : 9789187925436
Language : En, Es, Fr & De

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Book Description :

Download Regulation of Artemisinin Biosynthesis in Artemisia Annua L book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Artemisia annua

Artemisia annua Book
Author : Tariq Aftab,M. Naeem,M. Masroor A. Khan
Publisher : CRC Press
Release : 2017-12-14
ISBN : 1351802860
Language : En, Es, Fr & De

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Book Description :

Artemisia annua is a well-known medicinal plant that has been utilized for a number of purposes, including malaria, for centuries. This is the first comprehensive book to cover the importance of Artemisia annua in the global health crisis and in the treatment against diseases. A component and extract, artemisinin, is the source of other derivatives which are also suitable for pharmaceutical use. The present demand for artemisinin far outpaces its supply. Researchers are working globally towards improving artemisinin content in the plant by various means. Artemisia annua: Prospects, Applications and Therapeutic Uses highlights the different approaches, including ‘omics', that are being used in current research on this immensely important medicinal plant. Providing comprehensive coverage of the agricultural and pharmaceutical uses of this plant, Artemisia annua will be essential reading for botanists, plant scientists, herbalists, pharmacognosists, pharmacologists and natural product chemists.

Pharmacokinetics of the Artemisinin Derivative Artesunate in Patients with Severe Falciparum Malaria and Quantitative Analysis of Artemisinin and Artemisinic Acid in Artemisia Annua L

Pharmacokinetics of the Artemisinin Derivative Artesunate in Patients with Severe Falciparum Malaria and Quantitative Analysis of Artemisinin and Artemisinic Acid in Artemisia Annua L  Book
Author : Yueming Qian
Publisher : Unknown
Release : 1992
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Analyse: Les taux de l'artémisinine et de l'acide artémisinique dans l'"Artemisia annua L" d'origines différents ont été déterminés par HPLC en utilisant la détection électrochimique et l'absorption dans l'UV. Il semble que les taux de ces deux composés sont inversement proportionnels. Le taux de l'artémisinine dépend de l'origine de la plante, de la période de plantation et du moment de la récolte.

A Detailed Chronological Record of Project 523 and the Discovery and Development of Qinghaosu Artemisinin

A Detailed Chronological Record of Project 523 and the Discovery and Development of Qinghaosu  Artemisinin  Book
Author : Zhang Jianfang
Publisher : Strategic Book Publishing
Release : 2013-02
ISBN : 1622121643
Language : En, Es, Fr & De

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Book Description :

This is an account of a project in China carried out in secrecy from the Chinese people and the Western World during the tumultuous years of the Cultural Revolution. Project 523, as it was called, resulted in one of the most significant advances in the treatment of malaria since the discovery and first use of quinine over 300 years ago. The origin of the project was a request from the North Vietnamese Government to Mao Zedong in China, for assistance in managing chloroquine drug-resistant malaria affecting their military forces during the Vietnam-American war. Initially the project was directed by the Chinese military medical research authorities, but it became so large that civilian scientists were called upon to help. Ultimately, to accomplish this task, over 60 institutions and more than 500 scientists and other personnel scattered throughout mainland China became involved. This achievement is all the more remarkable because it was accomplished during the Cultural Revolution using obsolete equipment, and at a time when all regular research was halted, scientists were harassed and denigrated, and academic and intellectual activity was discouraged or even forbidden. The drug discovered - artemisinin from the plant Qinghao (Artemisia annua L) - is now the most widely used treatment for malaria in the world.

Production of Artemisia Annua L Cell Biomass and Artemisinin Via Manipulation of Culture Medium Abiotic Culture Condition and Elicitation

Production of Artemisia Annua L  Cell Biomass and Artemisinin Via Manipulation of Culture Medium  Abiotic Culture Condition and Elicitation Book
Author : Kiah Yann Lo
Publisher : Unknown
Release : 2014
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Production of Artemisia Annua L Cell Biomass and Artemisinin Via Manipulation of Culture Medium Abiotic Culture Condition and Elicitation book written by Kiah Yann Lo, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Roots and Hormones Synergistic Control of Artemisinin Production in Artemisia Annua L Shoots

Roots and Hormones    Synergistic Control of Artemisinin Production in Artemisia Annua L  Shoots Book
Author : Khanh Van T. Nguyen
Publisher : Unknown
Release : 2011
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Abstract: Artemisinin is a potent antimalarial drug produced in the plant Artemisia annua. Earlier reports suggested that the roots play a key role in artemisinin production; however, it was not clear if other factors actually affected production instead of roots. Here the role of roots and two phytohormones, NAA and BAP, were studied to determine what role each plays in artemisinin production in the plant. Rooted Artemisia annua shoots produced significantly more artemisinin, arteannuin B, and deoxyartemisinin, the end products in the pathway, than unrooted shoots. Although roots do not seem to affect the levels of precursors, artemisinic acid and dihydroartemisinic acid, or regulate the transcription of the genes in the pathway, rooted plants developed larger trichome sacs suggesting that the accumulation of end products is linked to the expansion of the trichome sac. Unrooted shoots are grown in shooting medium containing higher amount of MS salts, vitamins, sucrose and two potent phytohormones, NAA and BAP. Rooted shoots grown in rooting medium containing either one or both of these hormones showed that NAA increased production of arteannuin B in the young leaves and artemisinin in the mature leaves; in mature leaves, however, arteannuin B was inhibited by NAA. BAP induced production of both the precursors and the end products, except for artemisinin, in the young and/or mature leaves. When rooted shoots with their roots removed were grown in rooting medium containing either one of these hormones, artemisinin was significantly less in cultures grown with BAP while there were no differences in metabolite levels in cultures grown with NAA. Although the importance of roots on the artemisinin biosynthetic pathway cannot be concluded, these results help improve our understanding of artemisinin biosynthesis as may prove useful for improving artemisinin production in field-grown crops.

Morphological Study of in Vitro Culture of Artemisia Annua L and Enhancement of Artemisinin Production Via Chemical Mutagenesis

Morphological Study of in Vitro Culture of Artemisia Annua L  and Enhancement of Artemisinin Production Via Chemical Mutagenesis Book
Author : E Shuen Leow
Publisher : Unknown
Release : 2014
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Morphological Study of in Vitro Culture of Artemisia Annua L and Enhancement of Artemisinin Production Via Chemical Mutagenesis book written by E Shuen Leow, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Enhancement of Artemsinin Content in Artemisia Annua L

Enhancement of Artemsinin Content in Artemisia Annua L Book
Author : Elias Gebremariam Oba
Publisher : LAP Lambert Academic Publishing
Release : 2012
ISBN : 9783659224171
Language : En, Es, Fr & De

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Book Description :

Artemisinin, a sesquiterpene lactone endoperoxide compound derived from Artemisia annua L., is highly effective against multi-drug resistant Plasmodium spp. In addition to its antimalaria activity, artemisinin now has been known for its various medicinal properties such as antiviral and anti-cancer activities. Nevertheless, one of the major challenges facing artemisinin production nowadays is its low yield per dry weight. Thus, in this study, enhancement of artemisinin content in plant parts produced from different culturing systems was investigated by using plant bioregulator in order to provide other alternative sources of artemisinin production besides the field grown plants. Our result showed the potential use of CPPU in promoting artemisinin accumulation in both the hairy root system and transplanted pots of A. annua. It was also suggested that using effective stimulators with appropriate culturing system could enhance not only production of the target compound but also other useful compounds.

Selection of High Yieldings Strain of Artemisia Annua by Tissue Culture Techniques

Selection of High Yieldings Strain of Artemisia Annua by Tissue Culture Techniques Book
Author : Jinadasa Sunil
Publisher : Unknown
Release : 1993
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

The leaves of qinghao (Artemisia annua L.) produced artemisinin, an antimalarial drug. Since the plants are propagated by seds, artemisinin produced by each plant varies. The aetemisinin content of plantlets produced in our laboratory ranged from 0.13 to 0.48%. These plants were derived from seeds obtained from Vietnam. This paper outlines an in vitro selection method for high artemisinin yielding strains of Artemisia annua. [Author's abstract].

Establishment of in Vitro Plantlets of Artemisia Annua L for the Analysis of Artemisinin Biosynthetic Gene CYP71AV1 and Trichome Initiation Gene GL3

Establishment of in Vitro Plantlets of Artemisia Annua L  for the Analysis of Artemisinin Biosynthetic Gene  CYP71AV1  and Trichome Initiation Gene  GL3  Book
Author : Suganthi Appalasamy
Publisher : Unknown
Release : 2014
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Establishment of in Vitro Plantlets of Artemisia Annua L for the Analysis of Artemisinin Biosynthetic Gene CYP71AV1 and Trichome Initiation Gene GL3 book written by Suganthi Appalasamy, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Tu Youyou s Journey in the Search for Artemisinin

Tu Youyou s Journey in the Search for Artemisinin Book
Author : Zhang Wenhu,Wang Manyuan,Yang Lan
Publisher : World Scientific
Release : 2018-02-27
ISBN : 9813207663
Language : En, Es, Fr & De

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Book Description :

Tu Youyou's Journey in the Search for Artemisinin is an autobiographical science book chronicling in detail the great experiences of Tu Youyou from her childhood to winning the Nobel Prize in Physiology or Medicine. As Tu Youyou is the first female scientist from China to win the Nobel Prize in Physiology or Medicine, this win created a sudden wave of interest in medicine, resulting in numerous autobiographical books about Tu Youyou appearing on the market. Contrary to these mass market titles, this book is uniquely different as it is fully authorized by the Nobel laureate herself. Her once-confidential experimental data and Artemisinin research reports are now revealed in this book for all to learn and comprehend. In addition, one of the book authors, Dr Wang Manyuan, is the only PhD student supervised by Professor Tu. Pharmaceutical researchers can use the book's valuable contents to reference, quote and analyse while searching for their own scientific inspirations. It also successfully serves as a guide for budding scientists and future Nobel Prize winners as it provides the proper guidance and methods of scientific research.

Production of Cell Biomass and Artemisinin from Cell Cultures of Artemisia Annua L from Shake Flasks to Innovated Cell Culture Vessel

Production of Cell Biomass and Artemisinin from Cell Cultures of Artemisia Annua L  from Shake Flasks to Innovated Cell Culture Vessel Book
Author : King Wey Heng
Publisher : Unknown
Release : 2014
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Production of Cell Biomass and Artemisinin from Cell Cultures of Artemisia Annua L from Shake Flasks to Innovated Cell Culture Vessel book written by King Wey Heng, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Propagation of Selected Clones of Artemisia Annua L and Measurements of Their Artemisinin Content Under Laboratory and Field Conditions

Propagation of Selected Clones of Artemisia Annua L  and Measurements of Their Artemisinin Content Under Laboratory and Field Conditions Book
Author : Sunil Jinadasa
Publisher : Unknown
Release : 1994
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Plantlets derived from North Vietnam Artemisia annua seeds by tissue culture technique were heterogenous in population with variable artemisinin content. They were randomly selected and cloned. Statistical comparison of the artemisinin content from the various clones (3-week-old) indicated that they may be grouped as high [mean 0.41 %+0.02 SD (0.39-0.44 %), moderate [mean 0.25 % + 0.02 SD (0.23-0.29 %)] and low [mean 0.13 %+0.03 SD (0.09-0.16 %)] artemisinin yielders. The high artemisinin yielding clones when planted in the field continued to produce higher artemisinin content (0.18, 0.29 and 0.33 %) than the low yielding clones (0.06, 0.08, 0.09 and 0.13 %) after 3, 6, 9 and 12 weeks of growth respectively. [Authors' abstract].