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From Artemisia Annua L To Artemisinins

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From Artemisia Annua L to Artemisinins Hindi Edition

From Artemisia Annua L  to Artemisinins  Hindi Edition  Book
Author : Youyou Tu
Publisher : Unknown
Release : 2021-10-31
ISBN : 9781487804459
Language : En, Es, Fr & De

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Book Description :

From Artemisia annua L. to Artemisinins: The Discovery and Development of Artemisinins and Antimalarial Agents is the first book that systematically introduces the origin and development of artemisinine and artemisinine-based drugs. It includes four distinct sections, including Artemisia annua L., Artemisinin, Dihydroartemisinin, and other artemisinin derivatives. Tu Youyou, the chief inventor of artemisinin, together with other members from the research team, have written a book that will be a valuable reference work for both researchers involved in the medical industry and scholars who are interested in undertaking innovative research.

Artemisia annua Pharmacology and Biotechnology

Artemisia annua   Pharmacology and Biotechnology Book
Author : Tariq Aftab,Jorge F.S. Ferreira,M. Masroor A. Khan,M. Naeem
Publisher : Springer Science & Business Media
Release : 2013-11-26
ISBN : 3642410278
Language : En, Es, Fr & De

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Book Description :

Artemisinin, a sesquiterpene lactone originally extracted from the medicinal plant Artemisia annua L., is an effective antimalarial agent, particularly for multi-drug resistant and cerebral malaria. However, the concentration of artemisinin in the plant is very low. Because the chemical synthesis of artemisinin is complicated and not economically feasible in view of the poor yield of the drug, the intact plant remains the only viable source of artemisinin production. Therefore, it is necessary to increase the concentration of artemisinin in A. annua to reduce the cost of artemisinin based antimalarial drugs. Plant scientists have focused their efforts on A. annua for a higher artemisinin crop yield. With the present volume, we are bringing together the research which is being done on this plant throughout the world and future possibilities for scientists and researchers who want to work on it.

From Artemisia annua L to Artemisinins

From Artemisia annua L  to Artemisinins Book
Author : Youyou Tu
Publisher : Academic Press
Release : 2017-07-08
ISBN : 0128116560
Language : En, Es, Fr & De

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Book Description :

From Artemisia annua L. to Artemisinins: The Discovery and Development of Artemisinins and Antimalarial Agents is the first book that systematically introduces the origin and development of artemisinine and artemisinine-based drugs. It includes four distinct sections, including Artemisia annua L., Artemisinin, Dihydroartemisinin, and other artemisinin derivatives. Tu Youyou, the chief inventor of artemisinin, together with other members from the research team, have written a book that will be a valuable reference work for both researchers involved in the medical industry and scholars who are interested in undertaking innovative research. Presents a full view of artemisinin, not only its origin and development, but also chemical structure, chemical properties, extracting mode, derivatives, chromogenic reaction, general pharmacological, and toxicology. Provides many aspects of artemisinin-based drugs Incudes lots of experimental data, such as the X-ray crystallography result—the first application reported in China in determining the absolute molecular configuration utilizing the scattering effects of oxygen atoms by X-ray diffraction technique

Artemisia

Artemisia Book
Author : Colin W. Wright
Publisher : CRC Press
Release : 2001-10-18
ISBN : 0203303067
Language : En, Es, Fr & De

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Book Description :

A comprehensive overview of this genus, Artemisia examines all aspects of the herbs uses and applications, its mode of action and clinical importance. Following a comprehensive introduction to the genus, the book discusses the botanical, phytochemical and biological aspects of a number of important species of Artemisis. Considering that the discove

Artemisinin Based and Other Antimalarials

Artemisinin Based and Other Antimalarials Book
Author : Guoqiao Li,Ying Li,Zelin Li,Meiyi Zeng
Publisher : Academic Press
Release : 2017-11-28
ISBN : 0128132116
Language : En, Es, Fr & De

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Book Description :

Artemisinin-Based and Other Antimalarials: Detailed Account of Studies by Chinese Scientists Who Discovered and Developed Them provides a historical and scientific background of the discovery and development of artemisinin, artemisinin derivatives, combination drugs and related chemicals. It is a historical document, a scientific treatise, and a fascinating description of innovative research on new drug development that is carried out under extremely difficult conditions. The book also includes detailed experiments, physical-chemical procedures, practical methodologies and clinical trials. It is a valuable reference for students and researchers in the fields of scientific history, medicine, pharmaceutical science, chemistry, pharmacology and toxicology. Presents details of all stages of drug development, including in vitro experiment, animal exploratory studies, animal tests for toxicity, safety and efficacy followed by stages I, II, III and IV, safety and efficacy in human volunteers and patients with malaria Provides many physical-chemical laboratory procedures, such as NMR, MS, HPLC and X-ray diffraction used in drug development Includes practical methodology of clinical trials from many research centers and countries to demonstrate the importance of this discovery

Artemisia annua Pharmacology and Biotechnology

Artemisia annua   Pharmacology and Biotechnology Book
Author : Tariq Aftab,Jorge F.S. Ferreira,M. Masroor A. Khan,M. Naeem
Publisher : Springer
Release : 2013-12-11
ISBN : 9783642410260
Language : En, Es, Fr & De

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Book Description :

Artemisinin, a sesquiterpene lactone originally extracted from the medicinal plant Artemisia annua L., is an effective antimalarial agent, particularly for multi-drug resistant and cerebral malaria. However, the concentration of artemisinin in the plant is very low. Because the chemical synthesis of artemisinin is complicated and not economically feasible in view of the poor yield of the drug, the intact plant remains the only viable source of artemisinin production. Therefore, it is necessary to increase the concentration of artemisinin in A. annua to reduce the cost of artemisinin based antimalarial drugs. Plant scientists have focused their efforts on A. annua for a higher artemisinin crop yield. With the present volume, we are bringing together the research which is being done on this plant throughout the world and future possibilities for scientists and researchers who want to work on it.

Fighting Multidrug Resistance with Herbal Extracts Essential Oils and Their Components

Fighting Multidrug Resistance with Herbal Extracts  Essential Oils and Their Components Book
Author : Kateryna Volodymyrivna Kon,Mahendra Kumar Rai
Publisher : Elsevier Inc. Chapters
Release : 2013-05-24
ISBN : 0128066814
Language : En, Es, Fr & De

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Book Description :

High prevalence of multidrug-resistant microorganisms in the etiologic structure of different infectious processes significantly decreases the effectiveness of the treatment and enhances the probability of an unfavorable outcome from the infection. Combinations between antibiotics and other antimicrobial agents represent one of the most promising approaches for combating multidrug-resistant bacteria. A high therapeutic potential exists for combinations of antibiotics and natural antimicrobial substances with complex mechanisms of action and multiple healing properties, such as plant essential oils. The purpose of the present chapter is to review published studies on antibiotic-essential oil combinations and discuss the prospects for future studies. In general, many studies have shown the potential for essential oils to act synergistically with antibiotics in vitro. The main proposed mechanism of this beneficial effect is through inhibition of efflux pumps by some essential oils, which restores the activity of the antibiotic. Future efforts should be directed into further studies of antibiotic-essential oil combinations against multidrug-resistant bacteria, with an emphasis on understanding the mechanisms of the produced effect. Combinations of essential oils with different types of antimicrobial agents, such as bacteriophages, nanoparticles, and quorum-sensing inhibitors, require greater attention and are worthy of future investigations.

Artemisinin From Traditional Chinese Medicine to Artemisinin Combination Therapies Four Decades of Research on the Biochemistry Physiology and Breeding of Artemisia annua

Artemisinin   From Traditional Chinese Medicine to Artemisinin Combination Therapies  Four Decades of Research on the Biochemistry Physiology  and Breeding of Artemisia annua Book
Author : Tomasz Czechowski,Ian A. Graham,Pamela J. Weathers,Peter E. Brodelius,Geoffrey Duncan Brown
Publisher : Frontiers Media SA
Release : 2020-12-04
ISBN : 288966158X
Language : En, Es, Fr & De

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Book Description :

This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

Artemisia annua

Artemisia annua Book
Author : Tariq Aftab,M. Naeem,M. Masroor A. Khan
Publisher : CRC Press
Release : 2017-12-14
ISBN : 1351802852
Language : En, Es, Fr & De

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Book Description :

Artemisia annua is a well-known medicinal plant that has been utilized for a number of purposes, including malaria, for centuries. This is the first comprehensive book to cover the importance of Artemisia annua in the global health crisis and in the treatment against diseases. A component and extract, artemisinin, is the source of other derivatives which are also suitable for pharmaceutical use. The present demand for artemisinin far outpaces its supply. Researchers are working globally towards improving artemisinin content in the plant by various means. Artemisia annua: Prospects, Applications and Therapeutic Uses highlights the different approaches, including ‘omics', that are being used in current research on this immensely important medicinal plant. Providing comprehensive coverage of the agricultural and pharmaceutical uses of this plant, Artemisia annua will be essential reading for botanists, plant scientists, herbalists, pharmacognosists, pharmacologists and natural product chemists.

Extraction of Artemisinin from Artemisia Annua

Extraction of Artemisinin from Artemisia Annua Book
Author : Seid Yimer
Publisher : GRIN Verlag
Release : 2013-01-28
ISBN : 3656361665
Language : En, Es, Fr & De

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Book Description :

Bachelor Thesis from the year 2008 in the subject Engineering - Chemical Engineering, grade: A, Bahir Dar University (Bahir Dar University Engineering Faculity), course: Chemical Engineering, language: English, abstract: Abstract Malaria disease is endemic in least developed countries like Ethiopia. The rapid development of drug-resistant malaria parasite strain leaves the need for new effective anti-malarial drugs. Artemisinin is a sesquiterpene lactone found in the leaves and flowers of plants Artemisia annua L and have different chemical structures and higher efficacy than others. The content of artemisinin is very small and from 0.5 to 1.2 % of dry weight of plants in Ethiopia. Extraction of artemisinin from Artemisia annua is mainly performed using hydrocarbon extraction processes. Extraction with Supercritical CO2, ethanol, ionic liquids, hydroflourocarbon HFC-134a and hexane extraction are extraction technologies and compared majorly in terms of their extraction efficiency, cost and drawback to environment. Since artemisinin is only present in the epidermis of the leaves, leaves were only washed on the outside by stirring appeared to be the most appropriate method and the first step in this research was solvent extraction using hexane. Step followed purify by repeated crystallization. Laboratory scale production data and procedures were listed for aremisinin extraction process. By using those data large scale production method was designed. And did material and energy balance calculations for large scale production process carried out by taking scientific approach followed by feasibility study. As a result my extractor was very large and it has 14.37m3 capacities it wasn’t found in market. So I designed the required larger extractor that should fulfill the target of the project i.e. with simple, rapid, cost effective, environmental friendly and practical method for the isolation of artemisinin from Artemisia annua. The design the extractor I used the optimum ratio between solvent and leaves, optimum extraction time, optimum extraction temperature and optimum design of the stirrer paddles. In these thesis work extractor design, skirt design, bolt design, reinforcement calculations, preliminary equipment design (sizing), economic analysis calculations were included. In the profitability analysis Return on investment, payback period and net present worth calculated and the project was checked its feasibility. The payback period is 1.22yrs and it is economically acceptable that means this market is promising in Ethiopia in addition to save millions of Ethiopian and African from killer malaria. Key words: artemisinin, sesquiterpene lactone, hexane extraction

Medicinal Chemistry of Bioactive Natural Products

Medicinal Chemistry of Bioactive Natural Products Book
Author : Xiao-Tian Liang,Wei-Shuo Fang
Publisher : John Wiley & Sons
Release : 2006-03-17
ISBN : 0471739332
Language : En, Es, Fr & De

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Book Description :

Current discoveries and research into bioactive naturalproducts Medicinal Chemistry of Bioactive Natural Products provides amuch-needed survey of bioactive natural products and theirapplications in medicinal chemistry. This comprehensive referencefeatures articles by some of the world's leading scientists in thefield on discovery, structure elucidation, and elegant syntheticstrategies--developed for natural products--with an emphasis on thestructure activity relationship of bioactive natural products. Thetopics have been carefully chosen on the basis of relevance tocurrent research and to importance as clinicially usefulagents. Rather than attempting to be a comprehensive encyclopedia ofbioactive natural products, Medicinal Chemistry of BioactiveNatural Products guides the reader to the key developments in thefield. By providing not only practical detail but a historicalperspective on the chemistry and biology of the compounds underconsideration, the book serves as a handy resource for researchersin their own work developing pharmaceuticals, and as an inspiringintroduction for young scientists to the dynamic field of bioactivenatural products research. Enhanced by examples with updated research results, the discussioncovers such topics as: * The chemistry and biology of epothilones * Vancomycin and other glycopeptide antibiotic derivates * Antitumor and other related activities of Taxol and itsanalogs * The antimalarial properties of the traditional Chinese medicine,Quinghaosu (artemisinin) * Huperzine A: A natural drug for the treatment of Alzheimer'sdisease * The medicinal chemistry of ginkgolides from Ginkgo biloba * Recent progress in Calophyllum coumarins as potent anti-HIVagents * Plant-derived anti-HIV agents and analogs * Chemical synthesis of annonaceous acetogenins and theirstructurally modified mimics

A Detailed Chronological Record of Project 523 and the Discovery and Development of Qinghaosu Artemisinin

A Detailed Chronological Record of Project 523 and the Discovery and Development of Qinghaosu  Artemisinin  Book
Author : Zhang Jianfang
Publisher : Strategic Book Publishing
Release : 2013-02
ISBN : 1622121643
Language : En, Es, Fr & De

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Book Description :

This is an account of a project in China carried out in secrecy from the Chinese people and the Western World during the tumultuous years of the Cultural Revolution. Project 523, as it was called, resulted in one of the most significant advances in the treatment of malaria since the discovery and first use of quinine over 300 years ago. The origin of the project was a request from the North Vietnamese Government to Mao Zedong in China, for assistance in managing chloroquine drug-resistant malaria affecting their military forces during the Vietnam-American war. Initially the project was directed by the Chinese military medical research authorities, but it became so large that civilian scientists were called upon to help. Ultimately, to accomplish this task, over 60 institutions and more than 500 scientists and other personnel scattered throughout mainland China became involved. This achievement is all the more remarkable because it was accomplished during the Cultural Revolution using obsolete equipment, and at a time when all regular research was halted, scientists were harassed and denigrated, and academic and intellectual activity was discouraged or even forbidden. The drug discovered - artemisinin from the plant Qinghao (Artemisia annua L) - is now the most widely used treatment for malaria in the world.

Medicinal and Aromatic Plants XII

Medicinal and Aromatic Plants XII Book
Author : Y. P. S. Bajaj,Toshiyuki Nagata,Yutaka Ebizuka
Publisher : Springer Science & Business Media
Release : 2002-04-24
ISBN : 9783540416869
Language : En, Es, Fr & De

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Book Description :

Deals with the distribution, importance, conventional propagation, micropropagation, tissue culture study, and in vitro production of important medicinal and pharmaceutical compounds in plants.

Hepatotoxicity

Hepatotoxicity Book
Author : Hyman J. Zimmerman
Publisher : Lippincott Williams & Wilkins
Release : 1999
ISBN : 9780781719520
Language : En, Es, Fr & De

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Book Description :

Written by the foremost authority in the field, this volume is a comprehensive review of the multifaceted phenomenon of hepatotoxicity. Dr. Zimmerman examines the interface between chemicals and the liver; the latest research in experimental hepatotoxicology; the hepatotoxic risks of household, industrial, and environmental chemicals; and the adverse effects of drugs on the liver. This thoroughly revised, updated Second Edition features a greatly expanded section on the wide variety of drugs that can cause liver injury. For quick reference, an appendix lists these medications and their associated hepatic injuries. Also included are in-depth discussions of drug metabolism and factors affecting susceptibility to liver injury.

Traditional Medicinal Plants and Malaria

Traditional Medicinal Plants and Malaria Book
Author : Merlin Willcox,Gerard Bodeker,Philippe Rasoanaivo,Jonathan Addae-Kyereme
Publisher : CRC Press
Release : 2004-06-28
ISBN : 0203502329
Language : En, Es, Fr & De

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Book Description :

Malaria is an increasing worldwide threat, with more than three hundred million infections and one million deaths every year. The worlds poorest are the worst affected, and many treat themselves with traditional herbal medicines. These are often more available and affordable, and sometimes are perceived as more effective than conventional antimala

Fortschritte Der Chemie Organischer Naturstoffe

Fortschritte Der Chemie Organischer Naturstoffe Book
Author : László Zechmeister
Publisher : Unknown
Release : 1938
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Fortschritte Der Chemie Organischer Naturstoffe book written by László Zechmeister, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Preparation of Phytopharmaceuticals for the Management of Disorders

Preparation of Phytopharmaceuticals for the Management of Disorders Book
Author : Chukwuebuka Egbuna,Abhay Prakash Mishra,Megh R. Goyal
Publisher : Academic Press
Release : 2020-11-03
ISBN : 0128202858
Language : En, Es, Fr & De

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Book Description :

Preparation of Phytopharmaceuticals for the Management of Disorders: The Development of Nutraceuticals and Traditional Medicine presents comprehensive coverage and recent advances surrounding phytopharmaceuticals, nutraceuticals and traditional and alternative systems of medicines. Sections cover the concepts of phytopharmaceuticals, their history, and current highlights in phytomedicine. Also included are classifications of crude drugs, herbal remedies and toxicity, traditional and alternative systems of medicine, nanotechnology applications, and herbal cosmeticology. Final sections cover applications of microbiology and biotechnology in drug discovery. This book provides key information for everyone interested in drug discovery, including medicinal chemists, nutritionists, biochemists, toxicologists, drug developers and health care professionals. Students, professors and researchers working in the area of pharmaceutical sciences and beyond will also find the book useful. Includes the history and current highlights in phytomedicine, along with classifications of crude drugs, herbal drug technologies and herbal cosmeticology Provides detailed information on herbal remedies and toxicity, traditional and alternative systems of medicine, and applications of microbiology and biotechnology in drug discovery Discusses the nutritional and health benefits of nutraceuticals and how they help in the management and treatment of metabolic diseases

Medicinal Plants and Environmental Challenges

Medicinal Plants and Environmental Challenges Book
Author : Mansour Ghorbanpour,Ajit Varma
Publisher : Springer
Release : 2017-10-31
ISBN : 3319687174
Language : En, Es, Fr & De

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Book Description :

This book sheds new light on the role of various environmental factors in regulating the metabolic adaptation of medicinal and aromatic plants. Many of the chapters present cutting-edge findings on the contamination of medicinal plants through horizontal transfer, as well as nanomaterials and the biosynthesis of pharmacologically active compounds. In addition, the book highlights the impacts of environmental factors (e.g., high and low temperature, climate change, global warming, UV irradiation, intense sunlight and shade, ozone, carbon dioxide, drought, salinity, nutrient deficiency, agrochemicals, waste, heavy metals, nanomaterials, weeds, pests and pathogen infections) on medicinal and aromatic plants, emphasizing secondary metabolisms. In recent years, interest has grown in the use of bioactive compounds from natural sources. Medicinal and aromatic plants constitute an important part of the natural environment and agro-ecosystems, and contain a wealth of chemical compounds known as secondary metabolites and including alkaloids, glycosides, essential oils and other miscellaneous active substances. These metabolites help plants cope with environmental and/or external stimuli in a rapid, reversible and ecologically meaningful manner. Additionally, environmental factors play a crucial role in regulating the metabolic yield of these biologically active molecules. Understanding how medicinal plants respond to environmental perturbations and climate change could open new frontiers in plant production and in agriculture, where successive innovation is urgently needed due to the looming challenges in connection with global food security and climate change. Readers will discover a range of revealing perspectives and the latest research on this vital topic.

Medicinal and Aromatic Plants XII

Medicinal and Aromatic Plants XII Book
Author : Toshiyuki Nagata,Yutaka Ebizuka
Publisher : Springer Science & Business Media
Release : 2013-11-11
ISBN : 3662086166
Language : En, Es, Fr & De

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Book Description :

Medicinal and Aromatic Plants XII comprises 18 chapters. It deals with the distribution, importance, conventional propagation, micropropagation, tissue culture studies, and the in vitro production of important medicinal and pharmaceutical compounds in the following plants: Artemisia annua, Coriandrum sativum, Crataegus, Dionaea muscipula, Hyoscyamus reticulatus, Hypericum canariense, Leguminosae, Malva, Ocimum, Pergularia tomentosa, Phellodendron amurense, Sempervivum, Solanum aculeatissimum, S. chrysotrichum, S. kasianum, Stephania, Trigonella, and Vaccinium. It is tailored to the needs of advanced students, teachers, and research scientists in the fields of pharmacy, plant tissue culture, phytochemistry, biomedical engineering, and plant biotechnology in general.