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Forensic Practitioners Guide To The Interpretation Of Complex Dna Profiles

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Forensic Practitioner s Guide to the Interpretation of Complex DNA Profiles

Forensic Practitioner s Guide to the Interpretation of Complex DNA Profiles Book
Author : Peter Gill,Øyvind Bleka,Oskar Hansson,Corina Benschop,Hinda Haned
Publisher : Academic Press
Release : 2020-06-10
ISBN : 0128205687
Language : En, Es, Fr & De

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Book Description :

Over the past twenty years, there’s been a gradual shift in the way forensic scientists approach the evaluation of DNA profiling evidence that is taken to court. Many laboratories are now adopting ‘probabilistic genotyping’ to interpret complex DNA mixtures. However, current practice is very diverse, where a whole range of technologies are used to interpret DNA profiles and the software approaches advocated are commonly used throughout the world. Forensic Practitioner’s Guide to the Interpretation of Complex DNA Profiles places the main concepts of DNA profiling into context and fills a niche that is unoccupied in current literature. The book begins with an introduction to basic forensic genetics, covering a brief historical description of the development and harmonization of STR markers and national DNA databases. The laws of statistics are described, along with the likelihood ratio based on Hardy-Weinberg equilibrium and alternative models considering sub-structuring and relatedness. The historical development of low template mixture analysis, theory and practice, is also described, so the reader has a full understanding of rationale and progression. Evaluation of evidence and statement writing is described in detail, along with common pitfalls and their avoidance. The authors have been at the forefront of the revolution, having made substantial contributions to theory and practice over the past two decades. All methods described are open-source and freely available, supported by sets of test-data and links to web-sites with further information. This book is written primarily for the biologist with little or no statistical training. However, sufficient information will also be provided for the experienced statistician. Consequently, the book appeals to a diverse audience Covers short tandem repeat (STR) analysis, including database searching and massive parallel sequencing (both STRs and SNPs) Encourages dissemination and understanding of probabilistic genotyping by including practical examples of varying complexity Written by authors intimately involved with software development, training at international workshops and reporting cases worldwide using the methods described in this book

Interpreting Complex Forensic DNA Evidence

Interpreting Complex Forensic DNA Evidence Book
Author : Jane Moira Taupin
Publisher : CRC Press
Release : 2019-11-14
ISBN : 1351023764
Language : En, Es, Fr & De

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Book Description :

Interpreting Complex Forensic DNA Evidence is a handy guide to recent advances—and emerging issues—in interpreting complex DNA evidence and profiles for use in criminal investigations. In certain cases, DNA cannot be connected to a specific biological material such as blood, semen or saliva. How or when the DNA was deposited may be an issue. However, the possibility of generating DNA profiles from touched objects, where there may not be a visible deposit, has expanded the scope and number of exhibits submitted for DNA analysis. With such advances, and increasing improvements in technological capabilities in testing samples, this means it is possible to detect ever smaller amounts of DNA. There are also many efforts underway to seek was to interpret DNA profiles that are sub-optimal—either relative to the amount required by the testing kit and, potentially, the quality of the obtained sample. Laboratories often use enhancements in order to obtain a readable DNA profile. The broad-reaching implications of improving DNA sensitivity have led to this next, emerging generation of more complex profiles. Examples partial profiles that do not faithfully reflect the proposed donor, or mixtures of partial DNA from multiple people. A complexity threshold has been proposed to limit interpretation of poor-quality data. Research is now addressing the interpretation of transfer of trace amounts of DNA. Complex issues are arising in trial that need to be reconciled as such complexity has added challenges to the interpretation of evidence and its introduction or dismissal in certain cases in the courts. Interpreting Complex Forensic DNA Evidence provides tools to assist the criminal investigator, forensic expert, and legal professional when posed with a DNA result in a forensic report or testimony. The result—and any associated statistic—may not reveal any ambiguity, complexity, or the assumptions involved in deriving it. Questions from resolved criminal cases are posed, and the relevant forensic literature, are provided for the reader to assess a DNA result and any associated statistic. Case studies included throughout illustrate concepts and emphasize the need for conclusions in the forensic report that are data-driven and supported by the data.

Advanced Topics in Forensic DNA Typing Interpretation

Advanced Topics in Forensic DNA Typing  Interpretation Book
Author : John M. Butler
Publisher : Academic Press
Release : 2014-07-28
ISBN : 012405854X
Language : En, Es, Fr & De

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Book Description :

Advanced Topics in Forensic DNA Typing: Interpretation builds upon the previous two editions of John Butler’s internationally acclaimed Forensic DNA Typing textbook with forensic DNA analysts as its primary audience. Intended as a third-edition companion to the Fundamentals of Forensic DNA Typing volume published in 2010 and Advanced Topics in Forensic DNA Typing: Methodology published in 2012, this book contains 16 chapters with 4 appendices providing up-to-date coverage of essential topics in this important field. Over 80 % of the content of this book is new compared to previous editions. Provides forensic DNA analysts coverage of the crucial topic of DNA mixture interpretation and statistical analysis of DNA evidence Worked mixture examples illustrate the impact of different statistical approaches for reporting results Includes allele frequencies for 24 commonly used autosomal STR loci, the revised Quality Assurance Standards which went into effect September 2011

A Guide to Forensic DNA Profiling

A Guide to Forensic DNA Profiling Book
Author : Scott Bader
Publisher : John Wiley & Sons
Release : 2016-03-21
ISBN : 1118751523
Language : En, Es, Fr & De

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Book Description :

The increasingly arcane world of DNA profiling demands that those needing to understand at least some of it must find a source of reliable and understandable information. Combining material from the successful Wiley Encyclopedia of Forensic Science with newly commissioned and updated material, the Editors have used their own extensive experience in criminal casework across the world to compile an informative guide that will provide knowledge and thought-provoking articles of interest to anyone involved or interested in the use of DNA in the forensic context. Following extensive introductory chapters covering forensic DNA profiling and forensic genetics, this comprehensive volume presents a substantial breadth of material covering: Fundamental material – including sources of DNA, validation, and accreditation Analysis and interpretation – including, extraction, quantification, amplification and interpretation of electropherograms (epgs) Evaluation – including mixtures, low template, and transfer Applications – databases, paternity and kinship, mitochondrial-DNA, wildlife DNA, single-nucleotide polymorphism, phenotyping and familial searching Court - report writing, discovery, cross examination, and current controversies With contributions from leading experts across the whole gamut of forensic science, this volume is intended to be authoritative but not authoritarian, informative but comprehensible, and comprehensive but concise. It will prove to be a valuable addition, and useful resource, for scientists, lawyers, teachers, criminologists, and judges.

Forensic Science Evidence and Expert Witness Testimony

Forensic Science Evidence and Expert Witness Testimony Book
Author : Paul Roberts,Michael Stockdale
Publisher : Edward Elgar Publishing
Release : 2018-11-30
ISBN : 1788111036
Language : En, Es, Fr & De

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Book Description :

Forensic science evidence plays a pivotal role in modern criminal proceedings. Yet such evidence poses intense practical and theoretical challenges. It can be unreliable or misleading and has been associated with miscarriages of justice. In this original and insightful book, a global team of prominent scholars and practitioners explore the contemporary challenges of forensic science evidence and expert witness testimony from a variety of theoretical, practical and jurisdictional perspectives. Chapters encompass the institutional organisation of forensic science, its procedural regulation, evaluation and reform, and brim with comparative insight.

An Introduction to Forensic Genetics

An Introduction to Forensic Genetics Book
Author : William Goodwin,Adrian Linacre,Sibte Hadi
Publisher : John Wiley & Sons
Release : 2007-11-27
ISBN : 0470010258
Language : En, Es, Fr & De

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Book Description :

An Introduction to Forensic Genetics is a comprehensive introduction to this fast moving area from the collection of evidence at the scene of a crime to the presentation of that evidence in a legal context. The last few years have seen significant advances in the subject and the development and application of genetics has revolutionised forensic science. This book begins with the key concepts needed to fully appreciate the subject and moves on to examine the latest developments in the field, illustrated throughout with references to relevant casework. In addition to the technology involved in generating a DNA profile, the underlying population biology and statistical interpretation are also covered. The evaluation and presentation of DNA evidence in court is discussed as well with guidance on the evaluation process and how court reports and statements should be presented. An accessible introduction to Forensic Genetics from the collection of evidence to the presentation of that evidence in a legal context Includes case studies to enhance student understanding Includes the latest developments in the field focusing on the technology used today and that which is likely to be used in the future Accessible treatment of population biology and statistics associated with forensic evidence This book offers undergraduate students of Forensic Science an accessible approach to the subject that will have direct relevance to their courses. An Introduction to Forensic Genetics is also an invaluable resource for postgraduates and practising forensic scientists looking for a good introduction to the field.

Molecular Forensics

Molecular Forensics Book
Author : Ralph Rapley,David Whitehouse
Publisher : John Wiley & Sons
Release : 2007-05-21
ISBN : 047002495X
Language : En, Es, Fr & De

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Book Description :

Molecular Forensics offers a comprehensive coverage of the increasingly important role that molecular analysis plays within forensic science. Starting with a broad introduction of modern forensic molecular technologies, the text covers key issues from the initial scenes of crime sampling to the use of evidential material in the prosecution of legal cases. The book also explores the questions raised by the growing debate on the applications of national DNA databases and the resulting challenges of developing, maintaining and curating such vast data structures. The broader range of applications to non-human cases is also discussed, as are the statistical pitfalls of using so-called unique data such as DNA profiles, and the ethical considerations of national DNA databases. An invaluable reference for students taking courses within the Forensic and Biomedical sciences, and also useful for practitioners in the field looking for a broad overview of the subject. Provides a comprehensive overview of modern forensic molecular technologies. Explores the growing debate on the applications of national DNA databases. Discusses the initial phases of investigation to the conclusion of cases involving molecular forensic analysis.

Introduction to Forensic DNA Evidence for Criminal Justice Professionals

Introduction to Forensic DNA Evidence for Criminal Justice Professionals Book
Author : Jane Moira Taupin
Publisher : CRC Press
Release : 2017-07-27
ISBN : 143989910X
Language : En, Es, Fr & De

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Book Description :

The use of DNA profiling in forensic cases has been considered the most innovative technique in forensic science since fingerprinting, yet for those with limited scientific knowledge, understanding DNA enough to utilize it properly can be a daunting task. Introduction to Forensic DNA Evidence for Criminal Justice Professionals is designed for nonsc

Clinical Trials with Missing Data

Clinical Trials with Missing Data Book
Author : Michael O'Kelly,Bohdana Ratitch
Publisher : John Wiley & Sons
Release : 2014-02-14
ISBN : 1118762533
Language : En, Es, Fr & De

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Book Description :

This book provides practical guidance for statisticians, clinicians, and researchers involved in clinical trials in the biopharmaceutical industry, medical and public health organisations. Academics and students needing an introduction to handling missing data will also find this book invaluable. The authors describe how missing data can affect the outcome and credibility of a clinical trial, show by examples how a clinical team can work to prevent missing data, and present the reader with approaches to address missing data effectively. The book is illustrated throughout with realistic case studies and worked examples, and presents clear and concise guidelines to enable good planning for missing data. The authors show how to handle missing data in a way that is transparent and easy to understand for clinicians, regulators and patients. New developments are presented to improve the choice and implementation of primary and sensitivity analyses for missing data. Many SAS code examples are included – the reader is given a toolbox for implementing analyses under a variety of assumptions.

Kirk Othmer Encyclopedia of Chemical Technology Volume 12

Kirk Othmer Encyclopedia of Chemical Technology  Volume 12 Book
Author : Kirk-Othmer
Publisher : Wiley-Interscience
Release : 2005
ISBN : 9780471485117
Language : En, Es, Fr & De

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Book Description :

The fifth edition of the Kirk-Othmer Encyclopedia of Chemical Technology builds upon the solid foundation of the previous editions, which have proven to be a mainstay for chemists, biochemists, and engineers at academic, industrial, and government institutions since publication of the first edition in 1949. * Over 1000 articles in 27 volumes * More than 600 new or updated articles

Search

Search Book
Author : N.A
Publisher :
Release : 1989
ISBN :
Language : En, Es, Fr & De

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Book Description :

Choice

Choice Book
Author : N.A
Publisher :
Release : 1997
ISBN :
Language : En, Es, Fr & De

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Book Description :

Forensic Nursing Science E Book

Forensic Nursing Science   E Book Book
Author : Virginia A. Lynch,Janet Barber Duval
Publisher : Elsevier Health Sciences
Release : 2010-07-23
ISBN : 0323066380
Language : En, Es, Fr & De

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Book Description :

Written and edited by the most respected authorities in forensic nursing and forensic sciences, this new edition provides the tools and concepts you need to collect evidence that is admissible in court, determine the significance of that evidence, and provide accurate, reliable testimony while administering high-quality patient care. Now in full color throughout, it remains the most comprehensive, highly illustrated text of its kind. Provides a comprehensive, updated guide to forensic nursing science, paying special attention to the International Association of Forensic Nurses’s (IAFN) goals for forensic nursing. Retains a focus on assessment skills and the collection and preservation of evidence, following the established guidelines of the forensic sciences. Prepares you to provide testimony as a fact witness or a forensic nursing expert. Includes an illustrated case study in almost every chapter, helping you relate the information to clinical practice. Highlights important recommendations for interventions in Best Practice boxes, including the evidence base for each. Summarizes important points in Key Point boxes, so you can quickly review the most important concepts in each chapter. Explores the evolving role of forensic nurses in today’s health care facilities and the community. Edited by Virginia Lynch, founding member and first President of the International Association of Forensic Nurses and Janet Barber Duval, both well-respected pioneers and educators in the field. Contains 300 full-color illustrations integrated throughout the text, so you can view evidence quickly and easily, as it is likely to appear in practice. Presents information on courtroom testimony and depositions in one reorganized, streamlined chapter, giving you a full, organized treatment of this extremely important topic. Includes twelve new chapters: Digital Evidence, Medical Evidence Recovery at the Death Scene, Asphyxia, Electrical and Thermal Injury, Intrafamilial Homicide and Unexplained Childhood Death, Human Trafficking, Credential Development for Forensic Nurses, Gangs and Hate Crimes, Ethics Issues in Forensic Nursing, Forensic Physics and Fracture Analysis, Sexual Deviant Behaviors and Crime and Forensic Epidemiology. Contains heavily revised information on Prehospital Evidence, Forensic Investigation in the Hospital, and Human Abuse and Deaths in Custody. Features critical thinking questions with every case study, so you can thoroughly consider the implications of each clinical scenario. Evolve site will include appendices and additional documentation materials.

Encyclopedia of Molecular Biology and Molecular Medicine Denaturation of DNA to Growth Factors

Encyclopedia of Molecular Biology and Molecular Medicine  Denaturation of DNA to Growth Factors Book
Author : Robert A. Meyers
Publisher : Wiley-Blackwell
Release : 1996-05-17
ISBN : 9783527284726
Language : En, Es, Fr & De

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Book Description :

This six volume Encyclopedia is the most comprehensive, detailed treatment of molecular biology and molecular medicine available today! The Encyclopedia provides a single-source library of molecular genetics and the molecular basis of life, with a focus on molecular medicine. Genetic screening, gene therapy, structural biology, and the technology and findings of the Human Genome Project are discussed in detail. The articles that comprise the set are designed as self-contained treatments. Each of the nearly 300 articles begins with an outline and a key word section which includes definitions. These features assist the scientist or student who is unfamiliar with a specific subject area. A glossary of basic terms completes each volume and defines the most commonly used terms in molecular biology. Together with the introductory illustrations found in each volume, these definitions enable readers to understand articles without referring to a dictionary, textbook, or other reference.

Forensic Science Handbook

Forensic Science Handbook Book
Author : Richard Saferstein
Publisher : Pearson College Division
Release : 2002
ISBN :
Language : En, Es, Fr & De

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Book Description :

The second in a three-volume series, this popular and widely circulated professional handbook describes the theories and practices of today's criminalistics, and covers a wide range of subject areas relevant to the services rendered by crime laboratories and related facilities. Presents authoritative reviews from recognized forensic criminologists and forensic scientists well-versed in their chosen areas of expertise. Considers a specific examination technique for a wide-range of evidence prevalent in the modern crime laboratory, e.g., DNA, hair, paint, soil, glass, petroleum products, explosives, alcohol in blood and breath, and questioned documents. Describes the theory, operation, and forensic utilization of such modern analytical instruments as mass spectrometry, capillary electrophoresis, high-performance liquid chromatography, and the visible microspectrophotometer. Emphasizes the symbiotic relationship between forensic science and criminal law as it examines the role and conduct of the expert witness, rules of evidence, and the legal requirements governing the admissibility of scientifically evaluated evidence.For professionals in forensic science and criminology.