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Fluorine Chemistry

Fluorine Chemistry Book
Author : J.H. Simons
Publisher : Elsevier
Release : 2012-12-02
ISBN : 0323142451
Language : En, Es, Fr & De

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Book Description :

Fluorine Chemistry, Volume IV provides an extensive survey and discussion on the physiological properties of fluoride ion and substances capable of producing it in aqueous solution. This book elaborates the detrimental effects of excessive fluoride ingestion, through the beneficial effects of optimal amounts, to recognized detrimental effects, such as dental caries accompanied by suboptimal fluoride intake. Fluoride metabolism is discussed in detail, including the capacity for storage of fluoride by the bones and rates of excretion of fluoride from the body. This text also covers the relation of fluoride ion to the health of teeth and bones. This publication is a good source for chemists and clinicians intending to acquire knowledge of the biological effects of fluoride.

Fluorine

Fluorine Book
Author : Alain Tressaud
Publisher : Academic Press
Release : 2018-10-06
ISBN : 0128129913
Language : En, Es, Fr & De

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Book Description :

Fluorine: A Paradoxical Element, Volume Five, deals with the link between fluorine, humanity and the environment. It is divided into three main sections, including i) The history and developmental stages of fluorinated products, ii) Awareness of its importance in our environment, and iii) Recent contributions of fluoride products in medicine, pharmacy and our daily lives. Made engaging through interesting figures and accessible language, and written by a leading expert, Professor Tressaud, the book supports the work of scientists working in materials, toxicology and environmental science. It complements the author’s edited series, Progress in Fluorine Science, covering recent advances. Describes background and contextual information regarding the history, development of understanding, and applications of this important element Explores the impacts of fluorine, both positive and negative, in the environment and biological systems Includes applied, real-world information from agencies, such as CNRS, NASA, HWS and DOH

Fluorine

Fluorine Book
Author : Victor R Preedy
Publisher : Royal Society of Chemistry
Release : 2015-04-17
ISBN : 1782624929
Language : En, Es, Fr & De

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Book Description :

Fluorine is best known for its role in the prevention of cavities and in improving oral and bone health however equally there are millions of people around the world suffering from dental fluorosis due to chronic exposure to high levels of fluoride in drinking water. This volume, written by leading researchers in this area, examines the positives and negatives of fluorine and its effects on humans for example fluoride-induced oxidative stress in the liver, effects of fluoride on insulin and preventing fluoride toxicity. Extremely useful for underpinning cross-disciplinary fluorine research, this book provides a fascinating insight for those with an interest in the health and nutritional sciences.

Graphite Fluorides Carbon Fluoride Compounds

Graphite Fluorides   Carbon Fluoride Compounds Book
Author : Tsuyoshi Nakajima,Nobuatsu Watanabe
Publisher : CRC PressI Llc
Release : 1991
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Graphite Fluorides Carbon Fluoride Compounds book written by Tsuyoshi Nakajima,Nobuatsu Watanabe, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Guide to Fluorine NMR for Organic Chemists

Guide to Fluorine NMR for Organic Chemists Book
Author : W. R. Dolbier
Publisher : John Wiley & Sons
Release : 2009-05-20
ISBN : 9780470483398
Language : En, Es, Fr & De

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Book Description :

AN UNPARALLELED ONE-STOP GUIDE TO FLUORINE NMR Guide to Fluorine NMR for Organic Chemists provides a unique single source on both fluorine NMR and the impact of fluorine substituents on proton and carbon NMR spectra. Helping working chemists overcome the challenges associated with the synthetic methodologies of fluorinated compounds, this guide enables the effective use of these increasingly popular spectroscopic techniques to accurately characterize compounds that contain fluorine. Following a thorough introduction of fluorinated compounds, chapters in the text cover: An overview of fluorine NMR The single fluorine substituent The CF2 group The trifluoromethyl group More heavily fluorinated compounds Compounds and substituents with fluorine directly bound to heteroatoms With unparalleled depth and completeness, the coverage ranges from those compounds containing only a few fluorinated substituents, typically employed in pharmaceutical and agricultural applications, to more heavily fluorinated compounds. Featuring NMR data for more than 1,000 specific compunds and including more than 100 exemplary spectra, Guide to Fluorine NMR for Organic Chemists gives the working chemist and advanced student an essential tool for understanding cutting-edge NMR techniques and interpreting the resulting spectroscopic data.

Fluorine and Health

Fluorine and Health Book
Author : Alain Tressaud,Gunter Haufe
Publisher : Elsevier
Release : 2008-06-06
ISBN : 9780080558110
Language : En, Es, Fr & De

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Book Description :

Fluorine and Health presents a critical multidisciplinary overview on the contribution of fluorinated compounds to resolve the important global issue of medicinal monitoring and health care. The involved subjects are organized in three thematic parts devoted to Molecular Imaging, Biomedical Materials and Pharmaceuticals. Initially the key-position of partially fluorinated low molecular weight compounds labelled either with the natural 19F-isotope for Magnetic Resonance Imaging (MRI) or labelled with the radioactive [18F]-isotope for Positron Emission Tomography (PET) is highlighted. Both non-invasive methods belong to the most challenging in vivo imaging techniques in oncology, neurology and in cardiology for the diagnosis of diseases having the highest mortality in the industrialized countries. The manifold facets of fluorinated biomaterials range from inorganic ceramics to perfluorinated organic molecules. Liquid perfluorocarbons are suitable for oxygen transport and as potential respiratory gas carriers, while fluorinated polymers are connected to the pathology of blood vessels. Another important issue concerns the application of highly fluorinated liquids in ophthalmology. Moreover, fluorine is an essential trace element in bone mineral, dentine and tooth enamel and is applied for the prophylaxis and treatment of dental caries. The various origins of human exposure to fluoride species is detailed to promote a better understanding of the effect of fluoride species on living organisms. Medicinally relevant fluorinated molecules and their interactions with native proteins are the main focus of the third part. New molecules fluorinated in strategic position are crucial for the development of pharmaceuticals with desired action and optimal pharmacological profile. Among the hundreds of marketed active drug components there are more than 150 fluorinated compounds. The chapters will illustrate how the presence of fluorine atoms alters properties of bioactive compounds at various biochemical steps, and possibly facilitate its emergence as pharmaceuticals. Finally the synthetic potential of a fluorinase, the first C-F bond forming enzyme, is summarized. - New approach of topics involving chemistry, biology and medicinal techniques - Transdisciplinar papers on fluoride products - Importance of fluoride products in health - Updated data on specific topics

Fluorine Chemistry Research Advances

Fluorine Chemistry Research Advances Book
Author : Ira V. Gardiner
Publisher : Nova Publishers
Release : 2007
ISBN : 9781600217302
Language : En, Es, Fr & De

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Book Description :

Fluorine continues to intrigue chemists who overcome the challenge of handling this remarkable halogen and work to develop varied methods for synthesising fluorine compounds. The unique properties of these materials, ranging from inert perfluorocarbons and fluoropolymers to a multitude of other fascinating fluorinated compounds, firmly established their place amidst the technological achievements of the 20th Century. Fluorine substitution in biologically active compounds has become particularly significant in recent years. This book presents new and significant research in this field.

The Chemistry of Fluorine

The Chemistry of Fluorine Book
Author : T. A. O'Donnell
Publisher : Elsevier
Release : 2013-10-22
ISBN : 1483146421
Language : En, Es, Fr & De

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Book Description :

Pergamon Texts in Inorganic Chemistry, Volume 5: The Chemistry of Fluorine comprises a series of reviews on the physical and chemical properties of fluorine compounds. This book discusses the general properties of fluorine and fluorides; hydrogen fluoride solvent system; ionization in halogen fluorides; fluorides of main group elements; and chemical reactivity of higher fluorides of d- and f-transition elements. The production of elemental fluorine; acidity of hydrogen fluoride; preparative reactions in halogen fluorides; specificity of fluorination in rare gas reactivity; and bonding and structure in higher transition metal are also elaborated in this text. This publication is intended for chemical engineering students and chemists researching on the characteristics of fluorine and fluorides.

Experimental Methods in Organic Fluorine Chemistry

Experimental Methods in Organic Fluorine Chemistry Book
Author : Tomoya Kitazume
Publisher : Routledge
Release : 2019-06-14
ISBN : 1351449230
Language : En, Es, Fr & De

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Book Description :

In the fields of biologically active materials and functional materials, fluorinated organic materials are becoming a focus of significant interest. Over the past decade synthetic methodologies and reagents in fluorine chemistry have been developed, especially stereocontrolled synthetic methods, enzymatic resolution to synthesize enantiomers, fluoromethylated reagents, and fluorination reagents. These methods have contributed to the opening of new pathways for fluorinated materials. However, few fluorinated materials have been put to commercial use. Furthermore, there remain problems to be solved, such as the handling of the materials, availability of reagents and selectivity (stereo-, regio-, and/or chemoselectivity). Research chemists, technical engineers, and graduate students in all branches of chemistry, pharmaceutics, and material science interested in fluorinated materials need to know detailed experimental procedures of how to synthesize the target fluorinated materials. This volume summarizes the chemical and microbial methods for obtaining functionalized fluorinated materials for use as building blocks; detailed experimental methods (reaction conditions, solvent, temperature, handling techniques, etc.); and the stereoview (possible absolute configuration) of the structures with spectral data. Mono-, di-, tri-, and polyfluorinated materials derived from fluorinating agents, fluoromethylated reagents and building blocks are summarized. A chemical name index, molecular formula index, and reagent index are also included. The publication of this monograph will provide access to the enormous possibilities in fluorine chemistry, biological material chemistry, and functionalized material chemistry.

Modern Synthesis Processes and Reactivity of Fluorinated Compounds

Modern Synthesis Processes and Reactivity of Fluorinated Compounds Book
Author : Henri Groult,Frederic Leroux,Alain Tressaud
Publisher : Elsevier
Release : 2016-11-04
ISBN : 0128037903
Language : En, Es, Fr & De

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Book Description :

Modern Synthesis Processes and Reactivity of Fluorinated Compounds focuses on the exceptional character of fluorine and fluorinated compounds. This comprehensive work explores examples taken from all classes of fluorine chemistry and illustrates the extreme reactivity of fluorinating media and the peculiar synthesis routes to fluorinated materials. The book provides advanced and updated information on the latest synthesis routes to fluorocompounds and the involved reaction mechanisms. Special attention is given to the unique reactivity of fluorine and fluorinated media, along with the correlation of those properties to valuable applications of fluorinated compounds. Contains quality content edited, and contributed, by leading scholars in the field Presents applied guidance on the preparation of original fluorinated compounds, potentially transferable from the lab scale to industrial applications Provides practical synthesis information for a wide audience interested in fluorine compounds in many branches of chemistry, materials science, and physics

Handling and Use of Fluorine and Fluorine oxygen Mixtures in Rocket Systems

Handling and Use of Fluorine and Fluorine oxygen Mixtures in Rocket Systems Book
Author : Harold W. Schmidt
Publisher : Unknown
Release : 1967
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Handling and Use of Fluorine and Fluorine oxygen Mixtures in Rocket Systems book written by Harold W. Schmidt, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Fluorine in Heterocyclic Chemistry Volume 2

Fluorine in Heterocyclic Chemistry Volume 2 Book
Author : Valentine Nenajdenko
Publisher : Springer
Release : 2014-07-08
ISBN : 3319044354
Language : En, Es, Fr & De

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Book Description :

This two-volume work combines comprehensive information on the chemistry of the fluorinated heterocycles. The material has been divided such that the first volume is dedicated to 5-membered fluorinated heterocycles and macrocycles, while the second volume combines data connected with the chemistry of fluorine containing 6-membered heterocycles. Both volumes will be of interest to synthetic organic chemists in general, and particularly for those colleagues working in the fields of heterocyclic-compound chemistry, materials chemistry, medicinal chemistry, and fluorine chemistry. All information is presented and classified clearly to be effective source for broad auditory of chemists. It will be interesting for scientists working in the field of inorganic and coordination chemistry. Fluorinated heterocycles are becoming increasingly important in many areas including the pharmaceutical industry, materials science and agriculture. The presence of fluorine can result in substantial functional changes in the biological as well as physicochemical properties of organic compounds. Incorporation of fluorine into drug molecules can greatly affect their physicochemical properties, such as bond strength, lipophilicity, bioavailability, conformation, electrostatic potential, dipole moment, pKa etc. as well as pharmacokinetic properties, such as tissue distribution, rate of metabolism and pharmacological properties, such as pharmacodynamics and toxicology.

Fluorine in Stomatology and Hygiene

Fluorine in Stomatology and Hygiene Book
Author : Rafail Davidovich Gabovich,G. D. Ovrut{u0361}skiĭ
Publisher : Unknown
Release : 1977
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Fluorine in Stomatology and Hygiene book written by Rafail Davidovich Gabovich,G. D. Ovrut{u0361}skiĭ, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Efficient Preparations of Fluorine Compounds

Efficient Preparations of Fluorine Compounds Book
Author : Herbert W. Roesky
Publisher : John Wiley & Sons
Release : 2012-10-11
ISBN : 1118409442
Language : En, Es, Fr & De

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Book Description :

The definitive guide to creating fluorine-basedcompounds—and the materials of tomorrow Discovered as an element by the French chemist Henri Moissan in1886, through electrolysis of potassium fluoride in anhydroushydrogen fluoride—"le fluor," or fluorine, began its chemicalhistory as a substance both elusive and dangerous. With a slightpale yellow hue, fluorine is at room temperature a poisonousdiatomic gas. Resembling a spirit from a chemical netherworld,fluorine is highly reactive, difficult to handle, yet veryversatile as a reagent—with the power to form compounds withalmost any other element. Comprising 20% of pharmaceutical products and 30% ofagrochemical compounds, as well as playing a key role in electriccars, electronic devices, and space technology, compoundscontaining fluorine have grown in importance across the globe.Learning how to safely handle fluorine in the preparation ofinnovative new materials—with valuable newproperties—is of critical importance to chemists today.Bringing together the research and methods of leading scientists inthe fluorine field, Efficient Preparations of FluorineCompounds is the definitive manual to creating, andunderstanding the reaction mechanisms integral to a wide variety offluorine compounds. With sixty-eight contributed chapters, thebook's extensive coverage includes: Preparation of Elemental Fluorine Synthesis Methods for Exotic Inorganic Fluorides with VariedApplications Introduction of Fluorine into Compounds via Electrophilic andNucleophilic Reactions Direct Fluorination of Organic Compounds with ElementalFluorine Efficient Preparations of Bioorganic Fluorine Compounds Asymmetric Fluorocyclization Reactions Preparations of Rare Earth Fluorosulfides andOxyfluorosulfides The book offers methods and results that can be reproduced bystudents involved in advanced studies, as well as practicingchemists, pharmaceutical scientists, biologists, and environmentalresearchers. The only chemical resource of its kind, EfficientPreparations of Fluorine Compounds—from its firstexperiment to its last—is a unique window into the centuriesold science of fluorine and the limitless universe offluorine-based compounds.

Fluorine Its Compounds and Air Pollution

Fluorine  Its Compounds  and Air Pollution Book
Author : Air Pollution Technical Information Center
Publisher : Unknown
Release : 1976
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Fluorine Its Compounds and Air Pollution book written by Air Pollution Technical Information Center, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Fluorine Carbon and Fluoride Carbon Materials

Fluorine Carbon and Fluoride Carbon Materials Book
Author : Tsuyoshi Nakajima
Publisher : CRC Press
Release : 1994-12-20
ISBN : 1482293560
Language : En, Es, Fr & De

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Book Description :

"This outstanding reference presents the latest scientific findings concerning the synthesis, structure, thermodynamics, and physical and chemical properties of fluorine- and fluoride-carbon compounds elucidating their practical applications in lithium batteries, superhydrophobic composites, and the electrolytic production of elemental fluorine."

Guide to Fluorine NMR for Organic Chemists

Guide to Fluorine NMR for Organic Chemists Book
Author : William R. Dolbier, Jr.
Publisher : John Wiley & Sons
Release : 2016-08-22
ISBN : 111883111X
Language : En, Es, Fr & De

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Book Description :

Following its well-received predecessor, this book offers an essential guide to chemists for understanding fluorine in spectroscopy. With over 1000 compounds and 100 spectra, the second edition adds new data – featuring fluorine effects on nitrogen NMR, chemical shifts, and coupling constants. • Explains how to successfully incorporate fluorine into target molecules and utilize fluorine substituents to structurally characterize organic compounds • Includes new data on nitrogen NMR, focusing on N-15, to portray the influence of fluorine upon nitrogen NMR chemical shifts and coupling constants • Expands on each chapter from the first edition with additional data and updated discussion from recent findings • "The flawless ordering of material covered in this stand-alone volume is such that information can be found very easily." – Angewandte Chemie review of the first edition, 2010

Fluorine in Pharmaceutical and Medicinal Chemistry

Fluorine in Pharmaceutical and Medicinal Chemistry Book
Author : Véronique Gouverneur
Publisher : World Scientific
Release : 2012
ISBN : 1848166346
Language : En, Es, Fr & De

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Book Description :

Fluorine chemistry is an expanding area of research that is attracting international interest, due to the impact of fluorine in drug discovery and in clinical and molecular imaging (e.g. PET, MRI). Many researchers and academics are entering this area of research, while scientists in industrial and clinical environments are also indirectly exposed to fluorine chemistry through the use of fluorinated compounds for imaging. This book provides an overview of the impact that fluorine has made in the life sciences. In the first section, the emphasis is on how fluorine substitution of amino acids, peptides, nucleobases and carbohydrates can provide invaluable information at a molecular level. The following chapters provide answers to the key questions posed on the importance of fluorine in drug discovery and clinical applications. For examples, the reader will discover how fluorine has found its place as a key element improving drug efficacy, with reference to some of the best-selling drugs on the market. Finally, a thorough review on the design, synthesis and use of 18F-radiotracers for positron emission tomography is provided, and this is complemented with a discussion on how 19F NMR has advanced molecular and clinical imaging.

The Curious World of Fluorinated Molecules

The Curious World of Fluorinated Molecules Book
Author : Konrad Seppelt
Publisher : Elsevier
Release : 2020-10-30
ISBN : 0128198753
Language : En, Es, Fr & De

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Book Description :

The Curious World of Fluorinated Molecules: Molecules Containing Fluorine is the sixth volume in the Progress in Fluorine Science series and is edited by the world-renowned scientist Konrad Seppelt. Dr. Seppelt brings together a team of global experts to uncover the multifaceted nature of the most electronegative element in the Periodic Table. The book explores the fascinating world of unpredictable, fluorine-containing molecules through their discoveries, path to recognition, current state of the art, and impact on the broader fields of fluorinated materials development. This volume will inspire and energize researchers, future scientists, and educators working in fluorine chemistry. Highlights the current state of fundamental research of fluorinated molecules that either helped to rewrite the fundamental rules of chemistry or impacted modern material technologies Features contributions from a global team of leading experts in the field Provides a unique combination of the historical and current examples that explain the unique role that fluorine can play in advancing our understanding of the scientific method at large

Bioorganic and Medicinal Chemistry of Fluorine

Bioorganic and Medicinal Chemistry of Fluorine Book
Author : Jean-Pierre Bégué,Daniele Bonnet-Delpon
Publisher : John Wiley & Sons
Release : 2008-06-02
ISBN : 0470281871
Language : En, Es, Fr & De

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Book Description :

Provides a thorough overview of the role of fluorine in pharmaceutical science and development Includes chapters on fluorinated analogues of natural products, fluorinated amino acids and peptides, and derivatives of sugars Classifies marketed and in-development fluorinated pharmaceuticals according to their therapeutic classes