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Fibroblast Growth Factors

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Fibroblast Growth Factors

Fibroblast Growth Factors Book
Author : Xiaokun Li
Publisher : Academic Press
Release : 2018-06-20
ISBN : 0128161434
Language : En, Es, Fr & De

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Book Description :

Fibroblast Growth Factors presents research and results from the leading global research group on FGF, providing up-to-date and comprehensive coverage of the field. The book describes the history, basic research and growth engineering technology involved with FGFs, while also introducing detailed research methods. It comprises eight chapters that detail successes and problems in relation to wound healing of engineered growth factors and considers injury repair and regeneration, non-mitogenic mutants, structure modification, pathology, physiology, pharmacology, development, FGF/FGFR inhibitors, bioengineering, and new drug development. It will serve as a key reference book for researchers working on FGFs. Focuses on the growth engineering aspects of FGF-based drug development and its clinical applications Presents useful information on the history of FGFs, along with basic research and growth engineering technology Provides detailed, practical research methods and results obtained on FGFs Considers the successes and problems in engineering technology Offers up-to-date, comprehensive coverage from the world’s leading research group

Fibroblast Growth Factors

Fibroblast Growth Factors Book
Author : Xiaokun Li
Publisher : Academic Press
Release : 2023-03-01
ISBN : 9780443157936
Language : En, Es, Fr & De

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Book Description :

Fibroblast Growth Factors, Second Edition systematically introduces readers to FGF in the fields of injury repair and regeneration, endocrinology and metabolism, structure and modification, pharmaceutics, pharmacology, FGF/FGFR inhibitor, engineering and new drug development. Fibroblast growth factors (FGFs) are secreted protein ligands that act in a paracrine or endocrine fashion to carry out their pleiotropic functions in development, tissue homeostasis and metabolism. In recent years, more and more attention has been paid to this super family. This book covers the work from Li's team from 2013 to 2018. This work should be a helper primer to scientists, particularly young students entering the FGFs field with their eye toward basic research and application.

Endocrine FGFs and Klothos

Endocrine FGFs and Klothos Book
Author : Makoto Kuro-o
Publisher : Springer Science & Business Media
Release : 2012-03-06
ISBN : 1461408873
Language : En, Es, Fr & De

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Book Description :

Fibroblast growth factors (FGFs) have been recognized primarily as autocrine/paracrine factors that regulate embryonic development and organogenesis. However, recent studies have revealed that some FGFs function as endocrine factors and regulate various metabolic processes in adulthood. Such FGFs, collectively called endocrine FGFs, are comprised of three members (FGF15/19, FGF21, and FGF23: FGF15 is the mouse ortholog of human FGF19). These endocrine FGFs share a common structural feature that enables the endocrine mode of action at the expense of the affinity to FGF receptors. To restore the affinity to FGF receptors in their target organs, the endocrine FGFs have designated the Klotho family of transmembrane proteins as obligate co-receptors. By expressing Klothos in a tissue-specific manner, this unique co-receptor system also enables the endocrine FGFs to specify their target organs among many tissues that express FGF receptors.

Fibroblast Growth Factor 23

Fibroblast Growth Factor 23 Book
Author : Christian Faul,Kenneth White,Orlando Gutierrez
Publisher : Elsevier
Release : 2021-04-06
ISBN : 0128180374
Language : En, Es, Fr & De

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Book Description :

Fibroblast Growth Factor 23 describes how FGF23 was initially identified as a bone-derived factor targeting the kidney. As such, sections in this comprehensive book cover exciting research that shows that different FGF23 effects require distinct signaling receptors and mediators that differ among target tissues, cover FGF23 initially identified as a bone-derived factor targeting the kidney, look at FGF23 as a regulator of phosphate metabolism and beyond, and cover research on novel concepts of FGF receptor signaling. Additional sections cover biochemistry, pharmacology and nephrology, making this book an ideal reference source on FGF23. Provides a comprehensive collection of chapters on the diversity of FGF23's actions Highlights truly translational topics, from molecular signaling to physiology and mechanism of disease, discussing cell culture and animal models to study FGF23 Describes FGF23’s potential in the clinical setting as a biomarker or even drug target Presents leaders in the field who cover a wide spectrum of research backgrounds and expertise, including clinical and basic scientists who specialize in diseases, endocrinology, genetics, protein biochemistry, cell biology and physiology

FGF Signalling in Vertebrate Development

FGF Signalling in Vertebrate Development Book
Author : Mary Elizabeth Pownall,Harry V. Isaacs
Publisher : Morgan & Claypool Publishers
Release : 2010
ISBN : 1615040633
Language : En, Es, Fr & De

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Book Description :

The fibroblast growth factors (FGFs) represent one of the relatively few families of extracellular signalling peptides that have been shown in recent decades to be key regulators of metazoan development. FGFs are required for multiple processes in both protostome and deuterostome groups. Given the wide range of regulatory roles attributed to the FGFs, it is perhaps not surprising that misregulation of this signalling pathway has been implicated in a number of human disease conditions. The focus of the present review is to look at the fundamental components of the FGF pathway and illustrate how this highly conserved regulatory cassette has been deployed to regulate multiple, diverse processes during vertebrate development. This review will explore examples from several vertebrate model organisms and include discussions of the role of FGF signalling in regulating the establishment of the mesoderm, neural patterning, morphogenesis, myogenesis, limb development, and the establishment of right-left asymmetry. This volume is a printed version of a work that appears in the Colloquium Digital Library of Life Sciences. Colloquium titles cover all of cell and molecular biology and biomedicine, including the neurosciences, from the advanced undergraduate and graduate level up to the post-graduate and practicing researcher level. They offer concise, original presentations of important research and development topics, published quickly, in digital and print formats. For more information, visit www.morganclaypool.com

Fibroblast Growth Factors Biology And Clinical Application Fgf Biology And Therapeutics

Fibroblast Growth Factors  Biology And Clinical Application   Fgf Biology And Therapeutics Book
Author : Simons Michael
Publisher : World Scientific
Release : 2016-12-27
ISBN : 981314338X
Language : En, Es, Fr & De

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Book Description :

The fibroblast growth factor (FGF) family of ligands and the corresponding family of FGF receptor tyrosine kinases comprise one of the most versatile and diverse growth factor signaling families in vertebrates, found virtually in every tissue and cell type where they regulate metabolic and physiologic function, maintain tissue homeostasis, and mediate injury response, tissue repair, and regeneration. As a result, FGFs play critical roles in a wide variety of normal biological and abnormalities in FGF signaling can lead to a variety of disease states from developmental malformations, to atherosclerosis, pulmonary hypertension and cancer among many others. A thorough understanding of this system is necessary for critical insights into both normal and disease biology and is essential to development of rationale therapeutic strategies aimed at treatment of FGF-dependent diseases states. Recent years have seen advances in our understanding of FGFs role in endothelial and, more general, vascular biology, the subject of this book. In particular, FGFs have been implicated in the maintenance of vascular homeostasis and control of blood vessel permeability while aberrant FGF signaling has been shown to be central to the development of pulmonary hypertension, and endothelial-to-mesenchymal transition, a process implicated in the development of atherosclerosis. Finally, FGFs ability to stimulate blood vessel growth has been explored in therapeutic angiogenesis approaches. With this in mind, the present monograph is structured to provide comprehensive information to a reader interested in FGFs in general and vascular biology in particular. To this end, we explore everything from the structure and signaling of FGFs and their receptors (Chapters 1, 2 and 3) to their role in the regulation of vascular homeostasis (Chapter 4) and cardiovascular diseases (Chapters 5 and 6). We then address new developments in FGF therapeutics (chapter 7) and explore FGF biology in the epithelium (Chapter 8) thereby providing a complete analysis of this growth factor family biology in two closely related but distinctly different environments — endothelium and epithelium. Finally, we examine FGF biology in eye disease and in cancer. It is our hope that this comprehensive treatment of FGF vascular biology and its application will provide the reader with the accurate and timely summary of this rapidly moving field.

Fibroblast Growth Factor Receptor FGFR Signaling Pathway in Tumor

Fibroblast Growth Factor Receptor  FGFR  Signaling Pathway in Tumor Book
Author : Klaus Holzmann,Brigitte Marian
Publisher : Unknown
Release : 2020-08-31
ISBN : 9783039367849
Language : En, Es, Fr & De

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Book Description :

Fibroblast growth factor (FGF) signal transmission has an essential function in embryonic development and tissue repair, and is dysregulated in the vast majority of malignancies studied. The FGF signaling in the tumor cells is usually increased by autocrine and paracrine mechanisms and gives them a high growth potential, resistance to apoptosis, neoangiogenesis and metastasis, all essential parameters relevant for tumor progression. This makes FGFs, and their tyrosine kinase receptors FGFRs, valuable targets for therapeutic interventions. This book is a collection of 15 recent articles-both original work and reviews-that summarize the current research state effectively. The content covers FGF signaling aspects in gastric, skin, liver, esophageal cancer, melanoma, mesothelioma and glioblastoma, including one article that addresses the role of FGF in the tumor-microenvironment cross-talk. Several reports describe the development of compounds targeting FGFRs, their structure and interaction with the receptor molecules, and their effectivity in preclinical and clinical testing. In summary, the papers demonstrate the complexity of the topic, with various FGF ligands and receptors involved and the need for further research. They also present results that fuel hope that targeting cancer with dysfunctional FGF signaling can become a realistic treatment option.

Holland Frei Cancer Medicine

Holland Frei Cancer Medicine Book
Author : Robert C. Bast, Jr.,Carlo M. Croce,William N. Hait,Waun Ki Hong,Donald W. Kufe,Martine Piccart-Gebhart,Raphael E. Pollock,Ralph R. Weichselbaum,Hongyang Wang,James F. Holland
Publisher : John Wiley & Sons
Release : 2017-03-10
ISBN : 111900084X
Language : En, Es, Fr & De

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Book Description :

Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates

Molecular and Cellular Biology of Neuroprotection in the CNS

Molecular and Cellular Biology of Neuroprotection in the CNS Book
Author : Christian Alzheimer
Publisher : Springer Science & Business Media
Release : 2003-01-31
ISBN : 030647414X
Language : En, Es, Fr & De

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Book Description :

Univ. of Kiel, Germany. Text provides an overview of the recent developments in neuroprotective signaling and experimental neuroprotection. Also offers a detailed look at many of the highly intertwined processes that determine the fate of CNS neurons in the face of acute or chronic insults.

Handbook of Neurochemistry and Molecular Neurobiology

Handbook of Neurochemistry and Molecular Neurobiology Book
Author : Ramon Lim,Abel Lajtha
Publisher : Springer Science & Business Media
Release : 2006-09-18
ISBN : 0387303480
Language : En, Es, Fr & De

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Book Description :

"The Handbook is intended to be a service to the neuroscience community, to help in finding available and useful information, to point out gaps in our knowledge, and to encourage continued studies. It represents the valuable contributions of the many authors of the chapters and the guidance of the editors and most important, it represents support for research in this discipline. Based on the rapid advances in the years since the second edition."--Publisher's website.

Growth Factors

Growth Factors Book
Author : C. Bondy,D. LeRoith
Publisher : Elsevier
Release : 1996-06-25
ISBN : 9780080532653
Language : En, Es, Fr & De

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Book Description :

This series provides a variety of different discussions on topics within the field of growth factors and cytokines in health and disease.

Peptide Growth Factors and Their Receptors

Peptide Growth Factors and Their Receptors Book
Author : Anonim
Publisher : Unknown
Release : 1990
ISBN : 9780387511849
Language : En, Es, Fr & De

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Book Description :

Download Peptide Growth Factors and Their Receptors book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

CNS Injuries

CNS Injuries Book
Author : Martin Berry,Ann Logan
Publisher : CRC Press
Release : 2019-07-17
ISBN : 9781420048544
Language : En, Es, Fr & De

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Book Description :

The basic science of the cellular and molecular responses of the brain to injury is a rapidly expanding area of research that provides evidence of growing opportunities for pharmacological intervention in the clinic. CNS Injuries: Cellular Responses and Pharmacological Strategies is an up-to-date examination of new developments in our understanding of the cellular and trophic responses to CNS injuries and the potential treatment. This text collates reviews of the most important areas of study regarding injury response including inflammatory and immune reactions scarring neuron death demyelination and remyelination axonal regeneration re-establishment of neuronal connectivity Providing a record of recent advances that will help point the way to future developments, this enlightening reference is sure to benefit researchers and practitioners in a broad range of disciplines, including: neurology, pharmacology, pathology, toxicology, immunology, and many others.

Fibroblast Growth Factors and Stem Cells in Regenerative Pharmacology and Anti Aging Intervention

Fibroblast Growth Factors and Stem Cells in Regenerative Pharmacology and Anti Aging Intervention Book
Author : Zhouguang Wang,Xiaokun Li,Q. Adam Ye,Saverio Bellusci,Yidong Wang
Publisher : Frontiers Media SA
Release : 2022-05-31
ISBN : 2889762882
Language : En, Es, Fr & De

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Book Description :

Download Fibroblast Growth Factors and Stem Cells in Regenerative Pharmacology and Anti Aging Intervention book written by Zhouguang Wang,Xiaokun Li,Q. Adam Ye,Saverio Bellusci,Yidong Wang, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Neuronal Growth Factors

Neuronal Growth Factors Book
Author : Mark Bothwell
Publisher : Springer Science & Business Media
Release : 2013-06-29
ISBN : 3642757472
Language : En, Es, Fr & De

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Book Description :

A host of environmental factors regulate the embryonic development of neurons. In adults, the survival of neurons, the regeneration of damaged axons, and plastic changes in axonal arborization are also controlled by a complex array of environmental cues. An important category of regulatory influences involves target-derived hormone-like peptides act ing on neuronal cell surface receptors. Nerve growth factor (NGF) was the first such factor to be characterized (LEVI MONTALCINI and HAMBURGER 1953) and has served as the model against which all similar factors are compared. A number of factors with properties similar to NGF have been described with activities toward differing populations of neurons. Many of these factors have been characterized only poorly at the biochemical level. However, several factors have been charac terized to the extent that molecular clones are available and complete amino acid sequences are known. These include: three structurally related factors, NGF itself (SCOTT et al. 1983), brain-derived neurotrophic factor (BDNF) (LEIBROCK et al. 1989), and neurotrophin-3 (NT-3) (MAISONPIERRE et al. 1990; HOHN et al. 1990); ciliary neurotrophic factor (CNTF) (LIN et al. 1989) and a second set of structural homologs; acidic and basic fibroblast growth factors (aFGF, bFGF) (ABRAHAM et al. 1986; JAYE et al. 1986). Investigators have cloned the receptors for NGF (JOHNSON et al. 1986; RADEKE et al. 1987) and FGF (LEE et al. 1989).

Growth Factors and Their Receptors in Cell Differentiation Cancer and Cancer Therapy

Growth Factors and Their Receptors in Cell Differentiation  Cancer and Cancer Therapy Book
Author : G V Sherbet
Publisher : Elsevier
Release : 2011-07-12
ISBN : 0123878209
Language : En, Es, Fr & De

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Book Description :

Recent years have seen a considerable emphasis on growth factors and the elucidation of their mode of function, which has led to the recognition that growth factors, their receptors as well as downstream elements of signalling associated with their function might be potential targets in therapeutic management of human diseases. Humanised monoclonal antibodies raised against growth factor receptors have proved to be valuable for targeted cancer treatment and in patient management. This book reviews the latest developments providing insights into the signalling processes involved in morphogenesis and pathogenesis with emphasis on using the elements of the signalling cascades as targets for therapeutic deployment. Provides a fundamental understanding of the basic functions of growth factors and their receptors, describing how they are linked in biological processes Aids the development of therapeutic treatments for cancer Focuses on the interrelationships and convergence of growth factors and their receptors in development and pathogenesis and encourages greater cooperation and integration in the areas of developmental, cancer and cancer therapeutic research

Branching Morphogenesis

Branching Morphogenesis Book
Author : Jamie Davies
Publisher : Springer Science & Business Media
Release : 2007-03-20
ISBN : 0387308733
Language : En, Es, Fr & De

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Book Description :

Branching morphogenesis, the creation of branched structures in the body, is a key feature of animal and plant development. This book brings together, for the first time, expert researchers working on a variety of branching systems to present a state-of-the-art view of the mechanisms that control branching morphogenesis. Systems considered range from single cells, to blood vessel and drainage duct systems to entire body plans, and approaches range from observation through experiment to detailed biophysical modelling. The result is an integrated overview of branching.

Malignant Cell Secretion

Malignant Cell Secretion Book
Author : Velibor Krsmanovic,James F. Whitfield
Publisher : CRC Press
Release : 2020-11-03
ISBN : 9780367226299
Language : En, Es, Fr & De

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Book Description :

First Published in 1990, this book offers a full, comprehensive guide into the nature of cells. Carefully compiled and filled with a vast repertoire of notes, pictures, and references this book serves as a useful reference for Students of Medicine, Microbiology, and other practitioners in their respective fields.

Encyclopedia of Movement Disorders

Encyclopedia of Movement Disorders Book
Author : Anonim
Publisher : Academic Press
Release : 2010-02-26
ISBN : 012374105X
Language : En, Es, Fr & De

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Book Description :

The Encyclopedia of Movement Disorders is a comprehensive reference work on movement disorders, encompassing a wide variety of topics in neurology, neurosurgery, psychiatry and pharmacology. This compilation will feature more than 300 focused entries, including sections on different disease states, pathophysiology, epidemiology, genetics, clinical presentation, diagnostic tools, as well as discussions on relevant basic science topics. This Encyclopedia is an essential addition to any collection, written to be accessible for both the clinical and non-clinical reader. Academic clinicians, translational researchers and basic scientists are brought together to connect experimental findings made in the laboratory to the clinical features, pathophysiology and treatment of movement disorders. The Encyclopedia targets a broad readership, ranging from students to general physicians, basic scientists and Movement Disorder specialists. Published both in print and via Elsevier’s online platform of Science Direct, this Encyclopedia will have the enhanced option of integrating traditional print with online multimedia. Connects experimental findings made in the laboratory to the clinical features, pathophysiology, and treatment of movement disorders Encompasses a wide variety of topics in neurology neurosurgery, psychiatry, and pharmacology Written for a broad readership ranging from students to general physicians, basic scientists, and movement disorder specialists