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Fibroblast Growth Factors

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Fibroblast Growth Factors Biology And Clinical Application Fgf Biology And Therapeutics

Fibroblast Growth Factors  Biology And Clinical Application   Fgf Biology And Therapeutics Book
Author : Simons Michael
Publisher : World Scientific
Release : 2016-12-27
ISBN : 981314338X
Language : En, Es, Fr & De

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Book Description :

The fibroblast growth factor (FGF) family of ligands and the corresponding family of FGF receptor tyrosine kinases comprise one of the most versatile and diverse growth factor signaling families in vertebrates, found virtually in every tissue and cell type where they regulate metabolic and physiologic function, maintain tissue homeostasis, and mediate injury response, tissue repair, and regeneration. As a result, FGFs play critical roles in a wide variety of normal biological and abnormalities in FGF signaling can lead to a variety of disease states from developmental malformations, to atherosclerosis, pulmonary hypertension and cancer among many others. A thorough understanding of this system is necessary for critical insights into both normal and disease biology and is essential to development of rationale therapeutic strategies aimed at treatment of FGF-dependent diseases states. Recent years have seen advances in our understanding of FGFs role in endothelial and, more general, vascular biology, the subject of this book. In particular, FGFs have been implicated in the maintenance of vascular homeostasis and control of blood vessel permeability while aberrant FGF signaling has been shown to be central to the development of pulmonary hypertension, and endothelial-to-mesenchymal transition, a process implicated in the development of atherosclerosis. Finally, FGFs ability to stimulate blood vessel growth has been explored in therapeutic angiogenesis approaches. With this in mind, the present monograph is structured to provide comprehensive information to a reader interested in FGFs in general and vascular biology in particular. To this end, we explore everything from the structure and signaling of FGFs and their receptors (Chapters 1, 2 and 3) to their role in the regulation of vascular homeostasis (Chapter 4) and cardiovascular diseases (Chapters 5 and 6). We then address new developments in FGF therapeutics (chapter 7) and explore FGF biology in the epithelium (Chapter 8) thereby providing a complete analysis of this growth factor family biology in two closely related but distinctly different environments — endothelium and epithelium. Finally, we examine FGF biology in eye disease and in cancer. It is our hope that this comprehensive treatment of FGF vascular biology and its application will provide the reader with the accurate and timely summary of this rapidly moving field.

Fibroblast Growth Factors

Fibroblast Growth Factors Book
Author : Xiaokun Li
Publisher : Academic Press
Release : 2018-06-20
ISBN : 0128161434
Language : En, Es, Fr & De

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Book Description :

Fibroblast Growth Factors presents research and results from the leading global research group on FGF, providing up-to-date and comprehensive coverage of the field. The book describes the history, basic research and growth engineering technology involved with FGFs, while also introducing detailed research methods. It comprises eight chapters that detail successes and problems in relation to wound healing of engineered growth factors and considers injury repair and regeneration, non-mitogenic mutants, structure modification, pathology, physiology, pharmacology, development, FGF/FGFR inhibitors, bioengineering, and new drug development. It will serve as a key reference book for researchers working on FGFs. Focuses on the growth engineering aspects of FGF-based drug development and its clinical applications Presents useful information on the history of FGFs, along with basic research and growth engineering technology Provides detailed, practical research methods and results obtained on FGFs Considers the successes and problems in engineering technology Offers up-to-date, comprehensive coverage from the world’s leading research group

Role Fibroblast Growth Factors Bronchi

Role Fibroblast Growth Factors Bronchi Book
Author : WIDYSATUTI
Publisher : Unknown
Release : 2012-06-05
ISBN : 9789461650528
Language : En, Es, Fr & De

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Book Description :

Download Role Fibroblast Growth Factors Bronchi book written by WIDYSATUTI, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Roles of Fibroblast Growth Factors FGF During Mammalian Liver Development

Roles of Fibroblast Growth Factors  FGF  During Mammalian Liver Development Book
Author : Joonil Jung
Publisher : Unknown
Release : 2000
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Roles of Fibroblast Growth Factors FGF During Mammalian Liver Development book written by Joonil Jung, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

The Fibroblast Growth Factor Signaling Pathway in Metabolic Regulation Development Disease and Repair After Injury

The Fibroblast Growth Factor Signaling Pathway in Metabolic Regulation  Development  Disease and Repair After Injury Book
Author : Zhouguang Wang,Xiaokun Li,Li Lin,Saverio Bellusci,Jin-San Zhang
Publisher : Frontiers Media SA
Release : 2020-11-19
ISBN : 2889661288
Language : En, Es, Fr & De

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Book Description :

Download The Fibroblast Growth Factor Signaling Pathway in Metabolic Regulation Development Disease and Repair After Injury book written by Zhouguang Wang,Xiaokun Li,Li Lin,Saverio Bellusci,Jin-San Zhang, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Fibroblast Growth Factor 23

Fibroblast Growth Factor 23 Book
Author : Christian Faul,Kenneth White,Orlando Gutierrez
Publisher : Elsevier
Release : 2021-04-06
ISBN : 0128180374
Language : En, Es, Fr & De

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Book Description :

Fibroblast Growth Factor 23 describes how FGF23 was initially identified as a bone-derived factor targeting the kidney. As such, sections in this comprehensive book cover exciting research that shows that different FGF23 effects require distinct signaling receptors and mediators that differ among target tissues, cover FGF23 initially identified as a bone-derived factor targeting the kidney, look at FGF23 as a regulator of phosphate metabolism and beyond, and cover research on novel concepts of FGF receptor signaling. Additional sections cover biochemistry, pharmacology and nephrology, making this book an ideal reference source on FGF23. Provides a comprehensive collection of chapters on the diversity of FGF23's actions Highlights truly translational topics, from molecular signaling to physiology and mechanism of disease, discussing cell culture and animal models to study FGF23 Describes FGF23’s potential in the clinical setting as a biomarker or even drug target Presents leaders in the field who cover a wide spectrum of research backgrounds and expertise, including clinical and basic scientists who specialize in diseases, endocrinology, genetics, protein biochemistry, cell biology and physiology

Structural Studies of Fibroblast Growth Factors and Their Receptors

Structural Studies of Fibroblast Growth Factors and Their Receptors Book
Author : N. J. Harmer
Publisher : Unknown
Release : 2004
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Structural Studies of Fibroblast Growth Factors and Their Receptors book written by N. J. Harmer, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Role and Putative Therapeutic Implications of Fibroblast Growth Factor 2 FGF 2 dependent Interplay of Neurotrophic Factors and Signaling Cascades in Amyotrophic Lateral Sclerosis

Role and Putative Therapeutic Implications of Fibroblast Growth Factor 2  FGF 2  dependent Interplay of Neurotrophic Factors and Signaling Cascades in Amyotrophic Lateral Sclerosis Book
Author : Ekaterini Sofia Kefalakes
Publisher : Unknown
Release : 2018
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Role and Putative Therapeutic Implications of Fibroblast Growth Factor 2 FGF 2 dependent Interplay of Neurotrophic Factors and Signaling Cascades in Amyotrophic Lateral Sclerosis book written by Ekaterini Sofia Kefalakes, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Fibroblast Growth Factors in Tooth Development

Fibroblast Growth Factors in Tooth Development Book
Author : Päivi Kettunen
Publisher : Unknown
Release : 1999
ISBN : 9789514589096
Language : En, Es, Fr & De

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Book Description :

Download Fibroblast Growth Factors in Tooth Development book written by Päivi Kettunen, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Heterologous Production of the Human Basic Fibroblast Growth Factor and the Glucosyltransferase S in Escherichia coli with and without Coproduction of Molecular Chaperones

Heterologous Production of the Human Basic Fibroblast Growth Factor and the Glucosyltransferase S in Escherichia coli with and without Coproduction of Molecular Chaperones Book
Author : Eriola Betiku
Publisher : Cuvillier Verlag
Release : 2005
ISBN : 3865373674
Language : En, Es, Fr & De

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Book Description :

Download Heterologous Production of the Human Basic Fibroblast Growth Factor and the Glucosyltransferase S in Escherichia coli with and without Coproduction of Molecular Chaperones book written by Eriola Betiku, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Fibroblast Growth Factors and the Onset of Spermatogenesis

Fibroblast Growth Factors and the Onset of Spermatogenesis Book
Author : Martin J. Seidensticker
Publisher : Unknown
Release : 1997
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Fibroblast Growth Factors and the Onset of Spermatogenesis book written by Martin J. Seidensticker, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Analysis of Fibroblast Growth Factor heparin Interactions

Analysis of Fibroblast Growth Factor heparin Interactions Book
Author : Ruoyan Xu
Publisher : Unknown
Release : 2012
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

The functions of a large number (> 435) of extracellular regulatory proteins are controlled by their interactions with heparan sulfate (HS). In the case of fibroblast growth factors (FGFs), HS binding controls their transport between cells and is required for the assembly of a high affinity signaling complex with the cognate FGF receptor. However, the specificity of the interaction of FGFs with HS is still debated. In this thesis, a panel of FGFs (FGF-1, FGF-2, FGF-7, FGF-9, FGF-18 and FGF-21) spanning five FGF sub-families were used to probe their specificities for HS/heparin at different levels: recombinant FGF proteins were expressed and purified and their biological activities tested in a DNA synthesis assay. Then, the proteins were tested for their heparin binding specificity using a variety of complementary approaches: 1. Measurement of the binding parameters of FGFs and a model heparin sugar in an optical biosensor or by microscale thermophoresis; 2. Identification of the heparin binding site (HBS) in the proteins using a Protect and Label strategy; 3. Determination of stability changes in FGFs when bound to different heparin sugars and related glycosaminoglycans employing differential scanning flurometry; 4. Measurement of the conformational changes in FGFs when binding to a variety of molar ratios of heparin and chemically modified heparins using synchrotron radiation circular dichroism (SRCD); 5. Measure directly the binding of FGF-2 to cellular HS using nanoparticles (NPs) to label the FGF-2 and transmission electron microscopy. For interaction with heparin, the FGFs have KDs varying between 38 nM (FGF-18) and 620 nM (FGF-9) and association rate constants spanning over 20-fold (FGF-1, 2,900,000 M-1s-1, FGF-9, 130,000 M-1s-1). The canonical HBS in FGF-1, FGF-2, FGF-7, FGF-9 and FGF-18 differs in its size and these FGFs have a different complement of secondary HBS, ranging from none (FGF-9) to two (FGF-1). Differential scanning fluorimetry identified clear preferences in these FGFs for distinct structural features in the polysaccharide. SRCD revealed conformational changes in FGFs induced by binding to heparin and the changes were distinct at different heparin concentrations. Moreover, there was evidence that the conformational changes of FGFs differed with chemically modified heparins, indicating that the conformational change caused by binding to heparin is related to the sulfation pattern. At the cellular level, FGF-2 labeled with nanoparticles allowed the distribution of FGF-2 to be determined in the pericellular matrix of Rama 27 fibroblasts. The results showed that the FGF-2-NPs were specifically bound to cellular HS and were clustered. Taken together, these data suggest that the differences in heparin binding sites in both the protein and the sugar are greatest between FGF sub-families and may be more restricted within a FGF sub-family in accord with the known conservation of function within FGF sub-families, which supports the idea that heparin binding of these proteins is specific, but in terms of consensus sites on the GAG chain, rather than precisely defined chemical structures.

Characterization of the Cysteine rich Fibroblast Growth Factor Receptor Complex

Characterization of the Cysteine rich Fibroblast Growth Factor Receptor Complex Book
Author : Michael Ezra Zuber
Publisher : Unknown
Release : 1995
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Characterization of the Cysteine rich Fibroblast Growth Factor Receptor Complex book written by Michael Ezra Zuber, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Functional and Evolutionary Studies of the Fibroblast Growth Factor Family

Functional and Evolutionary Studies of the Fibroblast Growth Factor Family Book
Author : Anonim
Publisher : Unknown
Release : 2011
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Fibroblast growth factors (FGF) are a large family of polypeptides with ubiquitous roles in normal growth and development. There are 22 known members of this family all of which contain a signature FGF core region and a heparin binding region. The N-terminal and C-terminal of each FGF differ largely and form the basis of their different interactions and observed functional diversity. FGFs interact with fibroblast growth factor receptors (FGFR) and heparan sulfate proteoglycans on cell surfaces to activate downstream signaling pathways leading to many physiological functions depending on the cell type and context. The FGF signaling system has crucial roles in development within invertebrates and vertebrates. The evolution of the FGF superfamily has not been well defined in previous studies. While functions of many members are known, this is a very complex family and there is still much to learn about the functions and specifically the evolution of this important super family of proteins. The aim of this study is to conduct a comprehensive evolutionary analysis of the FGF family in a wide array of genomes. Firstly, FGF family members will be identified in newly sequenced vertebrate genomes. This will be followed by phylogenetic analysis to determine relationships among FGF members with the sequences identified here and those previously identified. Finally, functional analysis will be done to identify regions of functional and evolutionary importance.