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Fibroblast Growth Factor 23

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Fibroblast Growth Factor 23

Fibroblast Growth Factor 23 Book
Author : Christian Faul,Kenneth White,Orlando Gutierrez
Publisher : Elsevier
Release : 2021-04-06
ISBN : 0128180374
Language : En, Es, Fr & De

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Book Description :

Fibroblast Growth Factor 23 describes how FGF23 was initially identified as a bone-derived factor targeting the kidney. As such, sections in this comprehensive book cover exciting research that shows that different FGF23 effects require distinct signaling receptors and mediators that differ among target tissues, cover FGF23 initially identified as a bone-derived factor targeting the kidney, look at FGF23 as a regulator of phosphate metabolism and beyond, and cover research on novel concepts of FGF receptor signaling. Additional sections cover biochemistry, pharmacology and nephrology, making this book an ideal reference source on FGF23. Provides a comprehensive collection of chapters on the diversity of FGF23's actions Highlights truly translational topics, from molecular signaling to physiology and mechanism of disease, discussing cell culture and animal models to study FGF23 Describes FGF23’s potential in the clinical setting as a biomarker or even drug target Presents leaders in the field who cover a wide spectrum of research backgrounds and expertise, including clinical and basic scientists who specialize in diseases, endocrinology, genetics, protein biochemistry, cell biology and physiology

SP287SERUM FIBROBLAST GROWTH FACTOR 23 FGF 23 SOLUBLE KLOTHO SKLOTHO AND SCLEROSTIN LEVELS AS MARKERS OF CARDIOVASCULAR COMPLICATIONS IN RUSSIAN PATIENTS WITH END STAGE OF RENAL DISEASE REGULAR HEMODIALYSIS AND HEMODIAFILTRATION ON LINE

SP287SERUM FIBROBLAST GROWTH FACTOR 23  FGF 23   SOLUBLE KLOTHO  SKLOTHO  AND SCLEROSTIN LEVELS AS MARKERS OF CARDIOVASCULAR COMPLICATIONS IN RUSSIAN PATIENTS WITH END STAGE OF RENAL DISEASE  REGULAR HEMODIALYSIS AND HEMODIAFILTRATION ON LINE   Book
Author : Anonim
Publisher : Unknown
Release : 2018
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download SP287SERUM FIBROBLAST GROWTH FACTOR 23 FGF 23 SOLUBLE KLOTHO SKLOTHO AND SCLEROSTIN LEVELS AS MARKERS OF CARDIOVASCULAR COMPLICATIONS IN RUSSIAN PATIENTS WITH END STAGE OF RENAL DISEASE REGULAR HEMODIALYSIS AND HEMODIAFILTRATION ON LINE book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

High Fibroblast Growth Factor 23 Levels Associated With Low Hemoglobin Levels in Patients With Chronic Kidney Disease Stages 3 and 4

High Fibroblast Growth Factor 23 Levels Associated With Low Hemoglobin Levels in Patients With Chronic Kidney Disease Stages 3 and 4 Book
Author : Anonim
Publisher : Unknown
Release : 2016
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Abstract : Abstract: In chronic kidney disease (CKD), decreased erythropoietin production, low serum active vitamin D levels, and high renin-angiotensin-aldosterone activities had been regarded as major causes of renal anemia. At present, no clinical data are available to elucidate the association between renal anemia and fibroblast growth factor 23 (FGF23) levels in CKD. This study aimed to access whether FGF23 is involved in the pathogenesis of renal anemia. This cross-sectional observational study included 53 stable outpatients with CKD stages 3 and 4. Our primary predictor was serum FGF23 levels and outcome was hemoglobin levels. Measurements contained hemoglobin, FGF23, 25-hydroxyvitamin D, intact parathyroid hormone, plasma renin, serum aldosterone, HbA1C levels, lipid and iron profiles, and serum and urine electrolytes. Mean age of our patients was 66.4 ± 12.8 (SD) years, mean estimated glomerular filtration rate 33.5 ± 13.9 mL/min/1.73 m 2, median FGF23 level 200 (25th–75th percentile, 124–303) pg/mL, vitamin D level 19.5 (25th–75th percentile, 14.0–25.9) ng/mL, and hemoglobin level 12.7 (25th–75th percentile, 10.7–13.75) g/dL. Even after adjusting multiple variables, lower hemoglobin levels correlated significantly with FGF23 levels that were higher than the median value (>200 pg/mL). Moreover, after adjusting for aldosterone, but not 25-hydroxyvitamin D, it decreased the association with FGF23 that higher than median level and hemoglobin levels. We also observed a significant decrease of hemoglobin level in the higher FGF23 group who had a diabetes history. High FGF23 levels were observed to be associated with low hemoglobin levels, which may be partially mediated through the effects of serum aldosterone levels in our patients with CKD stages 3 and 4. Furthermore, we also presumed that diabetes itself may have an impact on the loop among FGF23, hemoglobin, and aldosterone levels in these CKD patients.

SP377EFFECTS OF LOWER PHOSPHATE DIETS ON FIBROBLAST GROWTH FACTOR 23 IN PATIENTS WITH CHRONIC KIDNEY DISEASE SYSTEMATIC REVIEW AND META ANALYSIS

SP377EFFECTS OF LOWER PHOSPHATE DIETS ON FIBROBLAST GROWTH FACTOR 23 IN PATIENTS WITH CHRONIC KIDNEY DISEASE  SYSTEMATIC REVIEW AND META ANALYSIS  Book
Author : Anonim
Publisher : Unknown
Release : 2018
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download SP377EFFECTS OF LOWER PHOSPHATE DIETS ON FIBROBLAST GROWTH FACTOR 23 IN PATIENTS WITH CHRONIC KIDNEY DISEASE SYSTEMATIC REVIEW AND META ANALYSIS book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Endocrine and Paracrine Role of FGF23 and Klotho in Health and Disease

Endocrine and Paracrine Role of FGF23 and Klotho in Health and Disease Book
Author : Reinhold G. Erben,L. Darryl Quarles
Publisher : Frontiers Media SA
Release : 2019-04-05
ISBN : 2889458059
Language : En, Es, Fr & De

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Book Description :

αKlotho and fibroblast growth factor-23 (FGF23) were discovered independently about 20 years ago. Since their initial description, a series of exciting discoveries have revealed the important role of endocrine and paracrine FGF23 and αKlotho signaling not only for the physiological regulation of mineral and bone homeostasis, but also for the pathophysiology of diseases such as chronic kidney disease, left ventricular hypertrophy, myocardial infarction, hypertension, and disorders characterized by impaired bone mineralization. The 11 articles compiled in this Research Topic consist of three Original Research articles and 8 Reviews or Mini Reviews, and are an excellent source of information about the state of the art in the FGF23/αKlotho field, covering almost all aspects of FGF23/αKlotho biology.

FP317PROTEINURIA DECREASES IN THE ACTIVITY OF FIBROBLAST GROWTH FACTOR 23 AND REDUCED FGF23 ACTIVITY IS ASSOCIATED WITH RENAL PROGRESSION IN PATIENTS WITH CHRONIC KIDNEY DISEASE RESULT FROM KNOW CKD STUDY

FP317PROTEINURIA DECREASES IN THE ACTIVITY OF FIBROBLAST GROWTH FACTOR 23 AND REDUCED FGF23 ACTIVITY IS ASSOCIATED WITH RENAL PROGRESSION IN PATIENTS WITH CHRONIC KIDNEY DISEASE  RESULT FROM KNOW CKD STUDY  Book
Author : Anonim
Publisher : Unknown
Release : 2018
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download FP317PROTEINURIA DECREASES IN THE ACTIVITY OF FIBROBLAST GROWTH FACTOR 23 AND REDUCED FGF23 ACTIVITY IS ASSOCIATED WITH RENAL PROGRESSION IN PATIENTS WITH CHRONIC KIDNEY DISEASE RESULT FROM KNOW CKD STUDY book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

SP332CIRCULATING FIBROBLAST GROWTH FACTOR 23 LEVELS ARE ASSOCIATED WITH AN INCREASED RISK OF ANEMIA DEVELOPMENT IN PATIENTS WITH NON DIALYSIS CHRONIC KIDNEY DISEASE

SP332CIRCULATING FIBROBLAST GROWTH FACTOR 23 LEVELS ARE ASSOCIATED WITH AN INCREASED RISK OF ANEMIA DEVELOPMENT IN PATIENTS WITH NON DIALYSIS CHRONIC KIDNEY DISEASE  Book
Author : Anonim
Publisher : Unknown
Release : 2018
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download SP332CIRCULATING FIBROBLAST GROWTH FACTOR 23 LEVELS ARE ASSOCIATED WITH AN INCREASED RISK OF ANEMIA DEVELOPMENT IN PATIENTS WITH NON DIALYSIS CHRONIC KIDNEY DISEASE book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Index Medicus

Index Medicus Book
Author : Anonim
Publisher : Unknown
Release : 2003
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Index Medicus book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

FP545THE CLINICAL IMPACT OF FIBROBLAST GROWTH FACTOR 23 AND SCLEROSTIN ON VASCULAR CALCIFICATION IN PREVALENT HEMODIALYSIS PATIENTS

FP545THE CLINICAL IMPACT OF FIBROBLAST GROWTH FACTOR 23 AND SCLEROSTIN ON VASCULAR CALCIFICATION IN PREVALENT HEMODIALYSIS PATIENTS  Book
Author : Anonim
Publisher : Unknown
Release : 2018
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download FP545THE CLINICAL IMPACT OF FIBROBLAST GROWTH FACTOR 23 AND SCLEROSTIN ON VASCULAR CALCIFICATION IN PREVALENT HEMODIALYSIS PATIENTS book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

The Fibroblast Growth Factor Family

The Fibroblast Growth Factor Family Book
Author : Andrew Baird,Michael Klagsbrun,New York Academy of Sciences
Publisher : Unknown
Release : 1991
ISBN : 9780897666909
Language : En, Es, Fr & De

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Book Description :

Download The Fibroblast Growth Factor Family book written by Andrew Baird,Michael Klagsbrun,New York Academy of Sciences, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Vitamin D

Vitamin D Book
Author : Sol Epstein
Publisher : Endocrinology and Metabolism C
Release : 2010
ISBN : 9781437718171
Language : En, Es, Fr & De

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Book Description :

This issue features internationally renowned experts who have provided their expertise on a variety of topics related to the importance of vitamin D. It was not until feedback loops were identified between vitamin D production and parathyroid hormone, phosphate that it earned its place as a true endocrine hormone. Current social and economic conditions have brought it back into the limelight with outbreaks of rickets and osteomalacia even in developed countries. However its complex regulation, together with the identification and characterization of the vitamin D receptor and its role in influencing multiple genetic pathways and function has heralded a new era highlighting its importance in health and disease. This includes its role in autoimmune diseases such as multiple sclerosis, diabetes mellitus, cancer especially breast and prostate, skin, neurological and cognitive disorders, and infectious diseases such as tuberculosis. We now know that adequate levels of vitamin D it is important in preventing falls and fracture. The need for supplementation and the amount recommended has also changed considerably from what we previously considered sufficient. The ongoing development of selective active analogs of vitamin D targeted to specific organs and function leads to the exciting possibility of improving outcomes of diseases associated with vitamin D regulation.

RENAL DYSFUNCTION AND FGF 23 IN PATIENTS WITH RECENT SMALL SUBCORTICAL STROKE A PROSPECTIVE COHORT STUDY

RENAL DYSFUNCTION AND FGF 23 IN PATIENTS WITH RECENT SMALL SUBCORTICAL STROKE  A PROSPECTIVE COHORT STUDY  Book
Author : Thomas Gattringer
Publisher : Unknown
Release : 2017
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Background Cerebral small vessel disease (CSVD) may be part of a multisystemic small vessel disorder also affecting the kidneys, but most previous data on this topic was retrospective and used limited renal parameters. In this prospective study of stroke patients with CSVD-related recent small subcortical infarction (RSSI), we hypothesized that markers of renal dysfunction were associated with the burden of CSVD on baseline MRI and its progression at follow-up MRI.MethodsWe prospectively investigated 101 patients (mean age: 60u00b111 years, 73% men) with MRI-confirmed RSSI who underwent follow-ups until 15 months poststroke. Renal parameters assessed included eGFR, Albumin-Creatinine Ratio and fibroblast growth factor-23 (FGF-23, an early marker of renal dysfunction). Chronic kidney disease (CKD) was defined according to current guidelines. Baseline CSVD burden and progression were assessed on brain MRI. ResultsRSSI patients with CKD (n=24, 24%) had more severe WMH at baseline (Fazekas 2-3 in 58% vs. 36%, p=0.04), other MRI markers of chronic CSVD did not differ compared to patients without CKD. CKD did not predict CSVD progression at 15 months. However, patients in the highest FGF-23 quartile more frequently showed CSVD progression (50% vs. 21%, OR 3.89, p=0.03) and showed increased rates of recurrent vascular events in the observation period (53% vs. 19%, OR 4.93, p=0.003). ConclusionsAlthough the severity of WMH was associated with CKD, conventional parameters of renal dysfunction did not predict progression of CSVD. However, our data suggest FGF-23 as a new biomarker of CSVD progression and recurrence of vascular events in RSSI patients, which warrants further studies.

The Anterior Cruciate Ligament

The Anterior Cruciate Ligament Book
Author : Douglas W. Jackson,Steven P. Arnoczky
Publisher : Lippincott Williams & Wilkins
Release : 1993
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Focuses on structure function & biology of injury & heal- ing reconstruction & rehab. of anterior cruciate ligament.

Bulletin of the Mount Desert Island Biological Laboratory

Bulletin of the Mount Desert Island Biological Laboratory Book
Author : Mount Desert Island Biological Laboratory
Publisher : Unknown
Release : 2007
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Bulletin of the Mount Desert Island Biological Laboratory book written by Mount Desert Island Biological Laboratory, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Annals of Clinical Biochemistry

Annals of Clinical Biochemistry Book
Author : Anonim
Publisher : Unknown
Release : 2007
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Annals of Clinical Biochemistry book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.