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Estrogen Effects On Traumatic Brain Injury

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Estrogen Effects on Traumatic Brain Injury

Estrogen Effects on Traumatic Brain Injury Book
Author : Kelli A Duncan
Publisher : Academic Press
Release : 2014-12-29
ISBN : 0128017074
Language : En, Es, Fr & De

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Book Description :

This book demystifies, deconstructs, and simultaneously humanizes the field of estrogen-mediated neuroprotection following TBI, making the subject approachable to both researchers and advanced students. Bringing together leading researchers and practitioners to explain the basis for their work, methods, and their results, chapters explore what is known about the role of estrogens following damage to the brain. With topics covering induction of estrogen response, consequences of estrogen action, and mechanisms underlying estrogen mediated neuroprotection, Estrogen Effects on Traumatic Brain Injury is of great importance to teachers, researchers, and clinicians interested in the role that estrogens play following traumatic brain injury. Written to provide a foundational view of estrogens as neuroprotectors in TBI, appropriate for both researchers and advanced students Data Analysis boxes in each chapter help with data interpretation and offer guidelines on how best to understand results. A multidisciplinary approach to the methods, issues, empirical findings in the field of estrogen mediated neuroprotection. Detailed focus on how studies relate and build upon each other and the ways different methods of analysis inform each other. Written to provide clinicians with new and developing treatment options for patients in their field.

The Effects of Oestrogen and Progesterone on Outcome Following Experimental Traumatic Brain Injury in Rats

The Effects of Oestrogen and Progesterone on Outcome Following Experimental Traumatic Brain Injury in Rats Book
Author : Christine A. O'Connor
Publisher : Unknown
Release : 2004
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download The Effects of Oestrogen and Progesterone on Outcome Following Experimental Traumatic Brain Injury in Rats book written by Christine A. O'Connor, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

On the Basis of Sex Impact on Traumatic Brain Injury

On the Basis of Sex  Impact on Traumatic Brain Injury Book
Author : T. John Wu,Courtney L. Robertson,Aviva Jane Symes,Peter John Crack
Publisher : Frontiers Media SA
Release : 2021-10-01
ISBN : 2889711579
Language : En, Es, Fr & De

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Book Description :

Download On the Basis of Sex Impact on Traumatic Brain Injury book written by T. John Wu,Courtney L. Robertson,Aviva Jane Symes,Peter John Crack, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Estradiol Synthesized by Reactive Glia is a Potent Anti inflammatory in the Injured Vertebrate Brain

Estradiol  Synthesized by Reactive Glia  is a Potent Anti inflammatory in the Injured Vertebrate Brain Book
Author : Alyssa Pedersen
Publisher : Unknown
Release : 2015
ISBN : 9781321710182
Language : En, Es, Fr & De

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Book Description :

Neuroinflammation following traumatic brain injury (TBI) may have detrimental and beneficial effects that likely differ between the acute and chronic periods post-trauma. In birds and mammals, traumatic brain injury increases the expression of cytokines in microglia and aromatase ( estrogen synthase) in astroglia. In the songbird, TBI-induced synthesis of estrogens by glial aromatization is neuroprotective as aromatase inhibition and replacement with estradiol (E2) exacerbates and mitigates the extent of damage and apoptosis, respectively. The effect of glial estrogens on inflammation, however, remains unstudied. We hypothesized that induced astrocytic aromatization may affect neuroinflammation following TBI, via the synthesis of neural E2 around the site of damage. In three separate experiments on adult zebra finches (Taeniopygia guttata) of both sexes we tested the influence of (a) mechanical TBI, (b) inhibition of induced aromatase expression, and (c) inhibition of induced aromatase with central E2 replacement, on the expression of the pro-inflammatory cytokines TNFalpha, IL-1beta and IL-6, and aromatase. At 2-hour post-injury, in both sexes, TBI increased, and tended to elevate, TNFalpha and IL-1beta respectively. At 24-hour post-injury, also in both sexes, cytokines appeared to have returned to baseline, but aromatase is robustly elevated in the lobe that sustained TBI. Pharmacological inhibition of induced aromatization resulted in persistent neuroinflammation, as administration of fadrozole increased IL-1beta in females and TNFalpha in males 24 hour following TBI. This prolonged neuroinflammation following aromatase inhibition appears to be due to a failure to synthesize E2 locally, since E2 replacement lowered TNFalpha and IL-1beta relative to fadrozole alone. IL-6 was not affected by TBI, aromatase inhibition or E2 replacement in either sex. These data suggest that astrocytic E2 synthesis following TBI is a potent and inducible anti-inflammatory signal, with specific modulation of discrete cytokine signaling. Induced neural provision of E2 following damage and compromise of central pathways may protect the brain from the deleterious effects of prolonged neuroinflammation.

New Therapeutics for Traumatic Brain Injury

New Therapeutics for Traumatic Brain Injury Book
Author : Kim Heidenreich
Publisher : Academic Press
Release : 2016-09-27
ISBN : 0128027010
Language : En, Es, Fr & De

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Book Description :

New Therapeutics for Traumatic Brain Injury: Prevention of Secondary Brain Damage and Enhancement of Repair and Regeneration explores traumatic brain injury (TBI), a major cause of death and disability throughout the world. The delayed nature of the secondary injury phase suggests that there is a therapeutic window for pharmacological interventions or other approaches to prevent progressive tissue damage and improve functional outcomes. It is now apparent that therapeutic interventions should entail both protective and repair/regeneration strategies depending on the phase of brain injury. This book describes emerging experimental strategies for the treatment of TBI, including new anti-inflammatory or anti-apoptotic therapeutics that limit brain damage, and novel or repurposed drugs that enhance repair or regeneration of the brain after injury. Comprehensive overview of basic approaches and translational development of new therapies for TBI Edited by a prominent TBI researcher that includes contributions by leading global researchers in the field Presents a great resource for researchers and practitioners to learn more about the many evolving preclinical studies and clinical trials currently underway, and the challenges of bringing translational studies in TBI to the clinic

Traumatic Brain Injury

Traumatic Brain Injury Book
Author : Mark J. Ashley,David A. Hovda
Publisher : CRC Press
Release : 2017-07-28
ISBN : 1498710328
Language : En, Es, Fr & De

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Book Description :

The fourth edition of this text constitutes a continuation of 20 years of coverage of traumatic brain injury, and broadens the discussion of acquired brain injury. Within TBI, the paradigm shift from an injury occurring at a point in time to a disease entity of a chronic nature is changing the discussion of diagnosis, management, treatment and outcome assessment. Disease specification that differentiates TBIs by the mechanism of injury, the exact nature of the injury, the extent of injury, presence of co-morbidities and their exact nature, gender, age, race, and genome are emerging as crucial. Disease differentiation has impacted diagnosis, treatment and outcome.

Brain Injury Medicine

Brain Injury Medicine Book
Author : Ross Zafonte, DO
Publisher : Demos Medical Publishing
Release : 2007
ISBN : 9781888799934
Language : En, Es, Fr & De

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Book Description :

Covers the full continuum from early diagnosis and evaluation through rehabilitation, post-acute care, and community re-entry. Includes assessment and treatment, epidemiology, pathophysiology, neuroanatomy, neuroimaging, the neuroscientific basis for rehabilitation, ethical and medicolegal issues, life-care planning, and more.

The Neuroprotective Effects of Z bisdehydrodoisynolic Acid Following Traumatic Brain Injury

The Neuroprotective Effects of Z bisdehydrodoisynolic Acid Following Traumatic Brain Injury Book
Author : Steven L. Neese
Publisher : Unknown
Release : 2007
ISBN : 9780549032601
Language : En, Es, Fr & De

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Book Description :

Experiment 3 attempted to determine if Z-BDDA treatment reduced edema following CCI injury in young male rats. Analysis of percent brain water 50 hours following injury revealed a Z-BDDA induced decrease in hippocampal edema ipsilaterally in comparison to controls. No other differences were found.

Traumatic Brain Injury in Sports

Traumatic Brain Injury in Sports Book
Author : Mark Lovell,Jeffrey Barth,Michael Collins,Ruben Echemendia
Publisher : CRC Press
Release : 2004-01-01
ISBN : 9789026519611
Language : En, Es, Fr & De

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Book Description :

Traumatic brain injury (TBI) in sports has become an important international public health issue over the past two decades. However, until recently, return to play decisions following a sports-related traumatic brain injury have been based on anecdotal evidence and have not been based on scientifically validated clinical protocols. Over the past decade, the field of Neuropsychology has become an increasingly important component of the return to play decision making process following TBI. Neuropsychological assessment instruments are increasingly being adapted for use with athletes throughout the world and the field of sports neuropsychology appears to be a rapidly evolving subspecialty. This book provides a comprehensive overview of the application of neuropsychological assessment instruments in sports, and it is structured to present a global perspective on contemporary research. In addition to a review of current research, Traumatic Brain Injury in Sports: An International Neuropsychological Perspective, presents a thorough review of current clinical models that are being implemented internationally within American and Australian rules football, soccer, boxing, ice hockey, rugby and equestrian sports.

Neuroprotection

Neuroprotection Book
Author : Matilde Otero-Losada,Francisco Capani,Santiago Perez Lloret
Publisher : BoD – Books on Demand
Release : 2020-11-26
ISBN : 1838804390
Language : En, Es, Fr & De

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Book Description :

Neurological disease affects nearly 25%–30% of the world’s population, exerting enormous financial strain on the healthcare system. Estimated current costs are around $800 annual billion, and this number is expected to increase exponentially as the global population ages. As such, new and alternative neuroprotective strategies are urgently needed. This book examines some of the most promising approaches in neuroprotection as well as discusses current goals and prospects. Organized into three sections, chapters cover such topics as the use of cannabinoids, medicinal plants, and essential oils in Alzheimer’s and Parkinson’s; protein misfolding and the neuroprotective potential of vitamin E in cerebral ischemia; and potential new neurological treatments and their mechanisms of action.

Brain Injury

Brain Injury Book
Author : Robert S.B. Clark,Patrick Kochanek
Publisher : Springer Science & Business Media
Release : 2012-12-06
ISBN : 1461517214
Language : En, Es, Fr & De

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Book Description :

Brain Injury is the second volume in the book series, Molecular and Cellular Biology of Critical Care Medicine. In this volume, a group of internationally regarded experts in important areas of neuroscience and neurointensive care research address the molecular and cellular basis of acute brain injury. This text covers acute brain injury within a context relevant to the care of patients with critical neurologic injuries such as cardiac arrest, trauma and stroke. It includes recent data pertaining to established pathways such as neurotransmission, exitotoxicity, ionic-mechanisms, oxidative stress, inflammation, and cerebral vascular injury. In addition, rapidly developing areas such as cell signaling, adenosine pharmacology, apoptosis, mitochondrial dysfunction, neurocytoskeletal changes, and the role of trophic factors are reviewed from the level of in vitro modeling to human data. Other topics covered that are highly clinically relevant include the effect of genetic background and gender differences in outcome after brain injury, preconditioning, and the effects of currently used anesthetics and sedative agents in patients with brain injury.

Steroids and the Brain

Steroids and the Brain Book
Author : Takayoshi Ubuka,Ishwar Parhar,Vance L. Trudeau
Publisher : Frontiers Media SA
Release : 2020-07-10
ISBN : 2889638510
Language : En, Es, Fr & De

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Book Description :

Download Steroids and the Brain book written by Takayoshi Ubuka,Ishwar Parhar,Vance L. Trudeau, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Estrogen Analysis by Liquid Chromatography Mass Spectrometry

Estrogen Analysis by Liquid Chromatography   Mass Spectrometry Book
Author : Hien P. Nguyen
Publisher : Unknown
Release : 2010
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Estrogens are well known as female hormones associated with both health and disease. Although they have been reported as potential carcinogens, their use as therapy in the treatment of neurodegeneration has recently received a great deal of attention. The main goal of this work was to advance estrogen analysis using liquid chromatography - mass spectrometry (LC-MS) and associated techniques in order to support pre-clinical and clinical research on the neuroprotective effects of estrogens. Native estrogen analyses were performed in different types of biological samples, including human cerebrospinal fluid (CSF), horse serum, phosphate buffered saline - bovine serum albumin (PBS-BSA), mouse serum, and mouse brain. A derivatization step with dansyl chloride was used in sample preparation prior to the introduction of LC-MS to enhance the electrospray ionization efficiency of native estrogens, since they are poorly ionizable in aqueous liquid phases. The four dansylated estrogens were successfully analyzed in cerebrospinal fluid (CSF) using a heart-cutting two dimensional reversed-phase (2D RP) LC-tandem MS system; detection limits in the part-per-trillion concentration range were achieved. Interestingly, later elution and 2D-separation were considered to be factors that reduced interferences in the analysis of 17[alpha]- and 17[beta]-estradiol from CSF matrices. The matrix effects were further studied in other biological samples for these two estrogens, which are of most interest for their neuroprotective effects, using two sequentially connected C18 columns coupled with tandem MS. The data revealed that matrix effects were observed in mouse brain and gelded horse serum but not in mouse serum and PBS-BSA. In direct support of clinical trials, the stability of Premarin®Intravenous, a potential first response treatment for traumatic brain injury, was investigated under the conditions that mimic ambulance environment. The drug is a cocktail of estrogen metabolites mainly in the form of sulfates, generated from natural sources of pregnant mare's urine. The experiment was designed in a time frame of six months and Premarin®Intravenous was studied in the form of dry powder and reconstituted solutions. Although individual major components of the drug in reconstituted samples significantly varied at elevated temperatures of 100 and 120°F, they were considered to be fairly stable in the form of dry power with the variation less than or eaqual to 10%. It was noted that the variation was larger for reconstituted samples stored at elevated versus room temperature. Based on the diversity of estrogens and their metabolites, they were used as a model to study the mechanism of hydrophilic interaction chromatography (HILIC) in the conjunction with MS. The retention behavior of estrogens and their metabolites was investigated on five polar stationary phases. Two interaction models were applied, the partition and the surface adsorption model. Retention of the compounds, especially estrogen glucuronides, on the amide- and diol-bonded stationary phases could be best fit the surface adsorption model while mixed modes were observed on most stationary phases. The advantages of electrospray (ESI) - MS detection in conjunction with HILIC were also emphasized. The combination is considered to be ideal for providing an increased sensitivity over reversed phase separation approaches in many cases. A comprehensive literature review was carried out on this topic.

Hormones Brain and Behavior

Hormones  Brain and Behavior Book
Author : Anonim
Publisher : Academic Press
Release : 2016-11-09
ISBN : 0128036087
Language : En, Es, Fr & De

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Book Description :

Hormones, Brain and Behavior, Third Edition offers a state-of-the-art overview of hormonally-mediated behaviors, including an extensive discussion of the effects of hormones on insects, fish, amphibians, birds, rodents, and humans. Entries have been carefully designed to provide a valuable source of information for students and researchers in neuroendocrinology and those working in related areas, such as biology, psychology, psychiatry, and neurology. This third edition has been substantially restructured to include both foundational information and recent developments in the field. Continuing the emphasis on interdisciplinary research and practical applications, the book includes articles aligned in five main subject sections, with new chapters included on genetic and genomic techniques and clinical investigations. This reference provides unique treatment of all major vertebrate and invertebrate model systems with excellent opportunities for relating behavior to molecular genetics. The topics cover an unusual breadth (from molecules to ecophysiology), ranging from basic science to clinical research, making this reference of interest to a broad range of scientists in a variety of fields. Comprehensive and updated coverage of a rapidly growing field of research Unique treatment of all major vertebrate and invertebrate model systems with excellent opportunities for relating behavior to molecular genetics Covers an unusual breadth of topics and subject fields, ranging from molecules to ecophysiology, and from basic science to clinical research Ideal resource for interdisciplinary learning and understanding in the fields of hormones and behavior

Your Healthy Brain A Personal and Family Guide to Staying Healthy and Living Longer

Your Healthy Brain  A Personal and Family Guide to Staying Healthy and Living Longer Book
Author : Stephen J. Kiraly, MD, FRCPC
Publisher : Lulu.com
Release : 2014-09-30
ISBN : 1483414809
Language : En, Es, Fr & De

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Book Description :

Your Healthy Brain is a presentation of The Healthy Brain Program(c) which was an innovative approach to addressing brain care and the need for a long and healthy life, first presented to mental health professionals and then to the public, starting in 2000. The concepts were presented at many psychiatric conferences both in Canada and the USA, in a 10-lecture interactive workshop format to colleagues and to the public. They have gained popularity and some Community Mental Health Teams have adopted The Healthy Brain Program(c) as a platform for delivering brain care. After about 350 presentations, many colleagues and participants urged the publication of a book format. The first edition appeared in 2008. This book, Your Healthy Brain, is organized along the same lines as the lecture series, following the same headings, in two parts.

The Estrogen Fix

The Estrogen Fix Book
Author : Mache Seibel
Publisher : Rodale Books
Release : 2017-09-19
ISBN : 1635651964
Language : En, Es, Fr & De

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Book Description :

With groundbreaking research and an exciting new theory that will change the way women look at hormone replacement therapy for years of substantially improved health, happiness, and quality of life, The Estrogen Fix is a must-have book for every woman over 40. Dr. Mache Seibel, one of the leading doctors in women’s health and menopause, proves that every woman has an ideal time to more safely begin estrogen replacement. When administered at this time, referred to as “the estrogen window,” estrogen can lower your risk for breast cancer, heart disease, Alzheimer’s, diabetes, osteoporosis, and more while minimizing your symptoms. Offering hope, expertise, and concrete solutions to a rectifiable problem, The Estrogen Fix is the definitive book on hormonal health for women. If estrogen has you confused or worried, if you are toughing it out because it seems too complicated to figure it out, if your doctors are reluctant to treat you and your symptoms are making your life a challenge, this book is for you.

Women at War

Women at War Book
Author : Elspeth Cameron Ritchie,Anne L. Naclerio
Publisher : Oxford University Press, USA
Release : 2015
ISBN : 0199344531
Language : En, Es, Fr & De

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Book Description :

Reviews topics such as epidemiology, deployment health, reproductive and genitourinary issues, mothering, sexuality, PTSD and other psychological effects of war, wounds and disability, intimate partner violice, sexual assault, and suicide. It provides health care providers with insight that can help prepare and prevent illness in the female military population by bringing together researchers, clinicians, and service member experience and knowledge and presents the information in a practical, actionable format. It also highlights areas where data is lacking and more study is demanded--Cover.

The Good News About Estrogen

The Good News About Estrogen Book
Author : Uzzi Reiss, M.D.,Billie Fitzpatrick
Publisher : St. Martin's Press
Release : 2020-03-10
ISBN : 1250214548
Language : En, Es, Fr & De

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Book Description :

The latest information about estrogen, the body's enlivening powerhouse hormone. Why is estrogen crucial—and so misunderstood? How do I know if my estrogen level is “normal”? What is the best treatment for a hormonal imbalance? How does estrogen impact my reproductive cycle? Is hormone replacement therapy right for me? Is it only useful at menopause? How can I be my best, healthiest self now and in the future? Understanding estrogen—its function and interplay with all your other hormones and body systems—is key to a healthy, vibrant life. But far too many women remain unaware of the benefits of estrogen, and how it can be supplemented in natural, bioidentical form. This book, written by an expert in the field of OB-GYN and integrative medicine, offers an authoritative yet accessible approach to hormonal health. In The Good News About Estrogen, Dr. Uzzi Reiss draws upon the most up-to-date scientific research, as well as women’s stories from his decades of practice, to explain: - How hormones—and your levels of estrogen—change over time, and what you can do to achieve balance naturally or with hormone replacement therapy (HRT). - The good news about estrogen—how it can enhance energy, sexuality, and memory; alleviate premenstrual syndrome (PMS) or the side effects of menopause; help fight weight gain, anxiety, depression, and more. - Bioidentical hormones—why they are safe and crucial to your well-being at any age or stage, and how to choose which treatment plan is right for you. - How your everyday habits—what you eat, drink, wear, and breathe—can affect hormonal health, and which small lifestyle changes can make a big difference. - Nutrition and exercise—learn how each works hand-in-hand with hormones and can help you to achieve maximum physical and emotional fitness, promote bone health, prevent cardiovascular disease, and boost brain power.

The Handbook of Neuroprotection

The Handbook of Neuroprotection Book
Author : Kewal K. Jain
Publisher : Springer
Release : 2019-05-15
ISBN : 1493994654
Language : En, Es, Fr & De

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Book Description :

This fully revised edition explores the management of neurological disorders with a focus on neuroprotection, disease modification, and neuroregeneration rather than symptomatic treatment. Since the publication of the first edition, advances in biotechnology, particularly in cell and gene therapies, are reflected in this volume, as are numerous new and repurposed drugs in clinical trials. Overall, The Handbook of Neuroprotection serves as a comprehensive review of neuroprotection based on knowledge of the molecular basis of disorders of the central nervous system. In-depth and authoritative, The Handbook of Neuroprotection, Second Edition features a compendium of vital knowledge aimed at providing researchers with an essential reference for this key neurological area of study.

Estrogens and Memory

Estrogens and Memory Book
Author : Karyn M. Frick
Publisher : Oxford University Press, USA
Release : 2020
ISBN : 0190645903
Language : En, Es, Fr & De

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Book Description :

"A book about the influence of estrogens on memory would have been unthinkable as recently as 30 years ago. Although a few small studies in the late 1970's reported a beneficial effect of estrogens on memory in human women (Hackman and Galbraith, 1976; Fedor-Freybergh, 1977), examination of the role of estrogens in memory did not truly capture more widespread attention until the pioneering work of Barbara Sherwin and colleagues in 1988 and beyond. In her initial paper, Sherwin showed that bilateral removal of the ovaries (aka surgical menopause) led to impaired short-term and long-term memory, whereas treatment of surgically menopausal women with estradiol alone, testosterone alone, or estradiol plus testosterone prevented this decline (Sherwin, 1988). As a search for the terms "estrogen" and "memory" in PubMed illustrates, well over 2000 papers have been published on the subject of estrogens and memory in the ensuing decades. The vast majority of these studies have focused on the hippocampus, a bilateral medial temporal lobe structure essential for the formation of episodic memories, particularly those with spatial, contextual, relational, temporal, and recognition components (Olton et al., 1979; Morris et al., 1982; Kim and Fanselow, 1992; Squire, 1992; Cohen and Stackman, 2015; Tonegawa et al., 2015; Eichenbaum, 2017). Although various forms of learning and memory are mediated by numerous brain regions, including the prefrontal cortex, medial temporal lobe cortices, amygdala, striatum, and cerebellum, the hippocampus has received the lion's share of attention due to its central importance for episodic memory formation. Hippocampal damage produces profound retrograde amnesia for facts and events, as well as anterograde amnesia for new information and impairments in spatial navigation (Winocur, 1990; Anagnostaras et al., 2001; Clark et al., 2002; Gilboa et al., 2006). Hippocampal dysfunction in middle-aged and aged subjects is a primary contributor to age-related memory decline (Golumb et al., 1996; Grady et al., 2003; Apostolova et al., 2010; Burke and Barnes, 2010; Small et al., 2011; Yassa et al., 2011), and has also been implicated in the cognitive impairments observed in diseases such as schizophrenia and depression (Small et al., 2011; Nakahara et al., 2018; Santos et al., 2018; Ott et al., 2019). Moreover, the hippocampi of patients with Alzheimer's disease are substantially atrophied and burdened with copious amounts of amyloid plaques and neurofibrillary tangles, the hallmark pathologies of this insidious disease (Hyman et al., 1984; Walsh and Selkoe, 2004; Selkoe and Hardy, 2016). As such, understanding how estrogens influence hippocampal functioning may provide important insights not only about the fundamental neurobiology of memory processes, but also into the etiology of neuropsychiatric and neurodegenerative diseases"--