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Essentials Of Genomic And Personalized Medicine

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Essentials of Genomic and Personalized Medicine

Essentials of Genomic and Personalized Medicine Book
Author : Geoffrey S. Ginsburg,Huntington F Willard
Publisher : Academic Press
Release : 2009-10-02
ISBN : 9780080958118
Language : En, Es, Fr & De

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Book Description :

Derived from the comprehensive two-volume set, Genomic and Personalized Medicine also edited by Drs. Willard and Ginsburg, this work serves the needs of the evolving population of scientists, researchers, practitioners and students that are embracing one of the most promising avenues for advances in diagnosis, prevention and treatment of human disease. From principles, methodology and translational approaches to genome discoveries and clinical applications, Essentials of Genomic and Personalized Medicine will be a valuable resource for various professionals and students across medical disciplines, including human genetics and genomics, oncology, neuroscience, gene therapy, molecular medicine, pharmacology, and biomedical sciences. Updates with regard to diagnostic testing, pharmacogenetics, predicting disease susceptibility, and other important research components as well as chapters dedicated to cardiovascular disease, oncology, inflammatory disease, metabolic disease, neuropsychiatric disease, and infectious disease, present this book as an essential tool for a variety of professionals and students who are endeavouring into the developing the diverse and practical field of genomic and personalized medicine. * Full color throughout * Includes contributions on genetic counselling, ethical, legal/regulatory, and social issues related to the practice of genomic medicine from leaders in the field * Introductory chapter highlights differences between personalized and traditional medicine, promising areas of current research, and challenges to incorporate the latest research discoveries and practice * Ancillary material includes case studies and lab questions which highlight the collaborative approach to the science

Genomic and Personalized Medicine

Genomic and Personalized Medicine Book
Author : Anonim
Publisher : Academic Press
Release : 2012-10-30
ISBN : 0123822289
Language : En, Es, Fr & De

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Book Description :

Genomic and Personalized Medicine, Second Edition — winner of a 2013 Highly Commended BMA Medical Book Award for Medicine — is a major discussion of the structure, history, and applications of the field, as it emerges from the campus and lab into clinical action. As with the first edition, leading experts review the development of the new science, the current opportunities for genome-based analysis in healthcare, and the potential of genomic medicine in future healthcare. The inclusion of the latest information on diagnostic testing, population screening, disease susceptability, and pharmacogenomics makes this work an ideal companion for the many stakeholders of genomic and personalized medicine. With advancing knowledge of the genome across and outside protein-coding regions of DNA, new comprehension of genomic variation and frequencies across populations, the elucidation of advanced strategic approaches to genomic study, and above all in the elaboration of next-generation sequencing, genomic medicine has begun to achieve the much-vaunted transformative health outcomes of the Human Genome Project, almost a decade after its official completion in April 2003. Highly Commended 2013 BMA Medical Book Award for Medicine More than 100 chapters, from leading researchers, review the many impacts of genomic discoveries in clinical action, including 63 chapters new to this edition Discusses state-of-the-art genome technologies, including population screening, novel diagnostics, and gene-based therapeutics Wide and inclusive discussion encompasses the formidable ethical, legal, regulatory and social challenges related to the evolving practice of genomic medicine Clearly and beautifully illustrated with 280 color figures, and many thousands of references for further reading and deeper analysis

Essentials of Genomic and Personalized Medicine

Essentials of Genomic and Personalized Medicine Book
Author : Geoffrey S. Ginsburg,Huntington F Willard, PhD
Publisher : Academic Press
Release : 2009-10-08
ISBN : 9780123749345
Language : En, Es, Fr & De

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Book Description :

Derived from the comprehensive two-volume set, Genomic and Personalized Medicine also edited by Drs. Willard and Ginsburg, this work serves the needs of the evolving population of scientists, researchers, practitioners and students that are embracing one of the most promising avenues for advances in diagnosis, prevention and treatment of human disease. From principles, methodology and translational approaches to genome discoveries and clinical applications, Essentials of Genomic and Personalized Medicine will be a valuable resource for various professionals and students across medical disciplines, including human genetics and genomics, oncology, neuroscience, gene therapy, molecular medicine, pharmacology, and biomedical sciences. Updates with regard to diagnostic testing, pharmacogenetics, predicting disease susceptibility, and other important research components as well as chapters dedicated to cardiovascular disease, oncology, inflammatory disease, metabolic disease, neuropsychiatric disease, and infectious disease, present this book as an essential tool for a variety of professionals and students who are endeavouring into the developing the diverse and practical field of genomic and personalized medicine. * Full color throughout * Includes contributions on genetic counselling, ethical, legal/regulatory, and social issues related to the practice of genomic medicine from leaders in the field * Introductory chapter highlights differences between personalized and traditional medicine, promising areas of current research, and challenges to incorporate the latest research discoveries and practice * Ancillary material includes case studies and lab questions which highlight the collaborative approach to the science

Essentials of Cancer Genomic Computational Approaches and Precision Medicine

 Essentials of Cancer Genomic  Computational Approaches and Precision Medicine Book
Author : Nosheen Masood,Saima Shakil Malik
Publisher : Springer Nature
Release : 2020-03-20
ISBN : 9811510679
Language : En, Es, Fr & De

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Book Description :

This book concisely describes the role of omics in precision medicine for cancer therapies. It outlines our current understanding of cancer genomics, shares insights into the process of oncogenesis, and discusses emerging technologies and clinical applications of cancer genomics in prognosis and precision-medicine treatment strategies. It then elaborates on recent advances concerning transcriptomics and translational genomics in cancer diagnosis, clinical applications, and personalized medicine in oncology. Importantly, it also explains the importance of high-performance analytics, predictive modeling, and system biology in cancer research. Lastly, the book discusses current and potential future applications of pharmacogenomics in clinical cancer therapy and cancer drug development.

Essentials of Cancer Genomic Computational Approaches and Precision Medicine

 Essentials of Cancer Genomic  Computational Approaches and Precision Medicine Book
Author : Anonim
Publisher : Unknown
Release : 2020
ISBN : 9789811510687
Language : En, Es, Fr & De

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Book Description :

This book concisely describes the role of omics in precision medicine for cancer therapies. It outlines our current understanding of cancer genomics, shares insights into the process of oncogenesis, and discusses emerging technologies and clinical applications of cancer genomics in prognosis and precision-medicine treatment strategies. It then elaborates on recent advances concerning transcriptomics and translational genomics in cancer diagnosis, clinical applications, and personalized medicine in oncology. Importantly, it also explains the importance of high-performance analytics, predictive modeling, and system biology in cancer research. Lastly, the book discusses current and potential future applications of pharmacogenomics in clinical cancer therapy and cancer drug development.

Genomics Personalized Medicine and Oral Disease

Genomics  Personalized Medicine and Oral Disease Book
Author : Stephen T. Sonis, DMD, DMSc
Publisher : Springer
Release : 2015-09-17
ISBN : 331917942X
Language : En, Es, Fr & De

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Book Description :

The objective of this book is to catalyze the application of genomics to the diagnosis and treatment of oral diseases by comprehensively presenting focused discussions on the current state of knowledge. The first section book provides basic information about genetics, genomics and personalized medicine and the informatical methods available to apply and organize genetic data so that it has clinical relevance. Recognizing the genetic robustness of the oral cavity, the introductory section includes chapters on the oral micro biome and host genomics and response to infectious agents. The next two sections contain chapters which describe the genomics of specific oral diseases and conditions, including the genetic basis for mechanism and risk of treatment toxicities associated with cancer therapy and bisphosphonates. Four chapters focus on gene-based therapies and the pharmacogenomics applied to oral disease. The final chapter presents a provocative summary which describes a comprehensive vision of the melding of genomics to personalized medicine and the potential actionable outcomes that will likely affect clinical practice in the upcoming years.

Genomics and the Reimagining of Personalized Medicine

Genomics and the Reimagining of Personalized Medicine Book
Author : Richard Tutton
Publisher : Routledge
Release : 2016-04-15
ISBN : 1317129407
Language : En, Es, Fr & De

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Book Description :

Drawing on insights from work in medical history and sociology, this book analyzes changing meanings of personalized medicine over time, from the rise of biomedicine in the twentieth century, to the emergence of pharmacogenomics and personal genomics in the 1990s and 2000s. In the past when doctors championed personalization they did so to emphasize that patients had unique biographies and social experiences in the name of caring for their patients as individuals. However, since the middle of the twentieth century, geneticists have successfully promoted the belief that genes are implicated in why some people develop diseases and why some have adverse reactions to drugs when others do not. In doing so, they claim to offer a new way of personalizing the prediction, prevention and treatment of disease. As this book shows, the genomic reimagining of personalized medicine centres on new forms of capitalization and consumption of genetic information. While genomics promises the ultimate individualization of medicine, the author argues that personalized medicine exists in the imaginative gap between the problems and limits of current scientific practices and future prospects to individualize medical interventions. A rigorous, critical examination of the promises of genomics to transform the economics and delivery of medicine, Genomics and the Reimagining of Personalized Medicine examines the consequences of the shift towards personalization for the way we think about and act on health and disease in society. As such, it will be of interest to scholars and students of the sociology of medicine and health, science and technology studies, and health policy.

Individualized Medicine

Individualized Medicine Book
Author : Tobias Fischer,Martin Langanke,Paul Marschall,Susanne Michl
Publisher : Springer
Release : 2015-01-16
ISBN : 331911719X
Language : En, Es, Fr & De

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Book Description :

In 2009 the University Medicine Greifswald launched the “Greifswald Approach to Individualized Medicine” (GANI_MED) to implement biomarker-based individualized diagnostic and therapeutic strategies in clinical settings. Individualized Medicine (IM) has led not only to controversies about its potentials, but also about its societal, ethical and health economic implications. This anthology focusses on these areas and includes – next to clinical examples illustrating how the integrated analysis of biomarkers leads to significant improvement of therapeutic outcomes for a subgroup of patients – chapters about the definition, history and epistemology of IM. Additionally there is a focus on conceptual philosophical questions as well as challenges for applied research ethics (informed consent process, the IT-based consent management and the handling of incidental findings). Finally it pays attention to health economic aspects. The possibilities of IM to initiate a paradigm shift in the German health care provision are investigated. Furthermore, it is asked whether the G-DRG system is ready for the implementation of such approaches into clinical routine.

Essentials of Bioinformatics Volume II

Essentials of Bioinformatics  Volume II Book
Author : Noor Ahmad Shaik,Khalid Rehman Hakeem,Babajan Banaganapalli,Ramu Elango
Publisher : Springer Nature
Release : 2019-10-18
ISBN : 3030183750
Language : En, Es, Fr & De

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Book Description :

Bioinformatics is an integrative field of computer science, genetics, genomics, proteomics, and statistics, which has undoubtedly revolutionized the study of biology and medicine in past decades. It mainly assists in modeling, predicting and interpreting large multidimensional biological data by utilizing advanced computational methods. Despite its enormous potential, bioinformatics is not widely integrated into the academic curriculum as most life science students and researchers are still not equipped with the necessary knowledge to take advantage of this powerful tool. Hence, the primary purpose of our book is to supplement this unmet need by providing an easily accessible platform for students and researchers starting their career in life sciences. This book aims to avoid sophisticated computational algorithms and programming. Instead, it focuses on simple DIY analysis and interpretation of biological data with personal computers. Our belief is that once the beginners acquire these basic skillsets, they will be able to handle most of the bioinformatics tools for their research work and to better understand their experimental outcomes. Our second title of this volume set In Silico Life Sciences: Medicine provides hands-on experience in analyzing high throughput molecular data for the diagnosis, prognosis, and treatment of monogenic or polygenic human diseases. The key concepts in this volume include risk factor assessment, genetic tests and result interpretation, personalized medicine, and drug discovery. This volume is expected to train readers in both single and multi-dimensional biological analysis using open data sets, and provides a unique learning experience through clinical scenarios and case studies.

Handbook of Biomarkers and Precision Medicine

Handbook of Biomarkers and Precision Medicine Book
Author : Claudio Carini,Mark Fidock,Alain van Gool
Publisher : CRC Press
Release : 2019-04-16
ISBN : 0429574622
Language : En, Es, Fr & De

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Book Description :

"The field of Biomarkers and Precision Medicine in drug development is rapidly evolving and this book presents a snapshot of exciting new approaches. By presenting a wide range of biomarker applications, discussed by knowledgeable and experienced scientists, readers will develop an appreciation of the scope and breadth of biomarker knowledge and find examples that will help them in their own work." -Maria Freire, Foundation for the National Institutes of Health Handbook of Biomarkers and Precision Medicine provides comprehensive insights into biomarker discovery and development which has driven the new era of Precision Medicine. A wide variety of renowned experts from government, academia, teaching hospitals, biotechnology and pharmaceutical companies share best practices, examples and exciting new developments. The handbook aims to provide in-depth knowledge to research scientists, students and decision makers engaged in Biomarker and Precision Medicine-centric drug development. Features: Detailed insights into biomarker discovery, validation and diagnostic development with implementation strategies Lessons-learned from successful Precision Medicine case studies A variety of exciting and emerging biomarker technologies The next frontiers and future challenges of biomarkers in Precision Medicine Claudio Carini, Mark Fidock and Alain van Gool are internationally recognized as scientific leaders in Biomarkers and Precision Medicine. They have worked for decades in academia and pharmaceutical industry in EU, USA and Asia. Currently, Dr. Carini is Honorary Faculty at Kings’s College School of Medicine, London, UK. Dr. Fidock is Vice President of Precision Medicine Laboratories at AstraZeneca, Cambridge, UK. Prof.dr. van Gool is Head Translational Metabolic Laboratory at Radboud university medical school, Nijmegen, NL.

Molecular Medicine

Molecular Medicine Book
Author : R. J. Trent
Publisher : Academic Press
Release : 2012
ISBN : 0123814510
Language : En, Es, Fr & De

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Book Description :

Molecular Medicine is the application of genetic or DNA-based knowledge to the modern practice of medicine. Molecular Medicine, 4e, provides contemporary insights into how the genetic revolution is influencing medical thinking and practice. The new edition includes recent changes in personalized medicine, new growth in omics and direct-to-consumer DNA testing, while focusing on advances in the Human Genome project and implications of the advances in clinical medicine. Graduate students, researchers, clinicians and allied health professionals will appreciate the background history and clinical application of up-to-date molecular advances. Extensively revised to incorporate the results of the Human Genome Project, it provides the latest developments in molecular medicine The only book in Molecular Medicine to reach its fourth edition Identifies current practice as well as future developments Presents extensive tables, well presented figures and resources for further understanding

Advancing Healthcare Through Personalized Medicine

Advancing Healthcare Through Personalized Medicine Book
Author : Priya Hays
Publisher : Springer Nature
Release : 2021-10-27
ISBN : 3030801004
Language : En, Es, Fr & De

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Book Description :

Download Advancing Healthcare Through Personalized Medicine book written by Priya Hays, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Essentials of Genomics and Bioinformatics

Essentials of Genomics and Bioinformatics Book
Author : Christoph W. Sensen
Publisher : John Wiley & Sons
Release : 2008-09-26
ISBN : 3527612653
Language : En, Es, Fr & De

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Book Description :

Provides an overview of the rapidly evolving field of genomics with coverage of nucleic acid technologies, proteomics and bioinformatics. It includes chapters on applications in human health, agriculture and comparative genomics and also contains two chapters on the legal and ethical issues of genomics, a topic that is becoming increasingly important as genomics moves out of the laboratory into practical applications.

Encyclopedia of Lifestyle Medicine and Health

Encyclopedia of Lifestyle Medicine and Health Book
Author : James M. Rippe
Publisher : SAGE
Release : 2011-12-08
ISBN : 1412950236
Language : En, Es, Fr & De

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Book Description :

These three volumes sort out the science behind nightly news reports and magazine cover stories, and help define the interdisciplinary field of lifestyle medicine and health.

Essentials of Medical Genomics

Essentials of Medical Genomics Book
Author : Stuart M. Brown,John G. Hay,Harry Ostrer
Publisher : John Wiley & Sons
Release : 2008-12-29
ISBN : 0470334495
Language : En, Es, Fr & De

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Book Description :

Six new chapters on vital topics of interest such as multilocus SNP genotyping (SNP chips), RNAi, ChIP-chip, and genomic tiling arrays New edition responds to reviewers' and users' desire for greater coverage—now the most useful handbook on the market! Practical, concise summary of everything about genomics and emerging technologies a busy physician or medical student should know Covers concepts and techniques that are in use in medicine now, as well as those on the cutting-edge of science relevant to medicine, from bioinformatics to DNA diagnostics and proteomics NEW: Includes chapter-end exercises, enhancing the utility of the new edition as a textbook NEW: PowerPoint slides of images available at instructor website

The Impact of Science and Technology on the Rights of the Individual

The Impact of Science and Technology on the Rights of the Individual Book
Author : Nicola Lucchi
Publisher : Springer
Release : 2016-06-14
ISBN : 3319304399
Language : En, Es, Fr & De

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Book Description :

The volume is devoted to the relevant problems in the legal sphere, created and generated by recent advances in science and technology. In particular, it investigates a series of cutting-edge contemporary and controversial case-studies where scientific and technological issues intersect with individual legal rights. The book addresses challenging topics at the intersection of communication technologies and biotech innovations such as freedom of expression, right to health, knowledge production, Internet content regulation, accessibility and freedom of scientific research.

Smart Nanotechnology with Applications

Smart Nanotechnology with Applications Book
Author : Cherry Bhargava,Amit Sachdeva,Pradeep Kumar Sharma
Publisher : CRC Press
Release : 2020-12-16
ISBN : 1000262480
Language : En, Es, Fr & De

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Book Description :

This comprehensive reference text discusses advance concepts and applications in the field of nanotechnology. The text presents a detailed discussion of key important concepts including nanomaterials and nanodevices, nano-bio interface, nanoscale memories, and semiconductor nanotechnology. It discusses applications of nanotechnology in the fields of aerospace engineering, cosmetic industry, pharmaceutical science, food industry, and the textile industry. The text will be useful for senior undergraduate and graduate students in the field of electrical engineering, electronics engineering, nanotechnology, and pharmaceutical science. Discussing fundamental, advanced concepts and their applications in a single volume, this text will be useful as a reference text for senior undergraduate and graduate students in the field of electrical engineering, electronics engineering, nanotechnology, and pharmaceutical science. It comprehensively discusses important concepts such as nano-robotics, carbon-based nanomaterials, and nanoscale memories. The text discusses advanced concepts of nanotechnology and its applications in the fields of textile, pharmaceutical sciences, aerospace, and food industry. It will be an ideal reference text for senior undergraduate and graduate students in the field of electrical engineering, electronics engineering, nanotechnology, and nanoscience.

Healthcare Infrastructure

Healthcare Infrastructure Book
Author : Bruce R. Schatz,Richard B. Berlin Jr.
Publisher : Springer Science & Business Media
Release : 2011-06-23
ISBN : 9780857294524
Language : En, Es, Fr & De

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Book Description :

The first systematic survey of Healthcare Infrastructure, this book describes the inevitable future of health systems. It gives a concrete plan for improved quality at diminished cost, via merger of personal medicine and public health. It discusses general aspects of infrastructure engineering and specific aspects of healthcare systems. It discusses current and future technologies for health measurement and management. This book outlines how the health of populations will be measured at the level of individuals, combining engineering and medicine to support viable health systems for the first time. This book is unique, in combining a systematic survey of health determinants with a research monograph on health technologies. Readers will gain a broad context and a deep knowledge of future information technology applied to health systems.

Smart Bioremediation Technologies

Smart Bioremediation Technologies Book
Author : Pankaj Bhatt
Publisher : Academic Press
Release : 2019-06-07
ISBN : 012818308X
Language : En, Es, Fr & De

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Book Description :

Smart Bioremediation Technologies: Microbial Enzymes provides insights into the complex behavior of enzymes and identifies metabolites and their degradation pathways. It will help readers work towards solutions for sustainable medicine and environmental pollution. The book highlights the microbial enzymes that have replaced many plant and animal enzymes, also presenting their applications in varying industries, including pharmaceuticals, genetic engineering, biofuels, diagnostics and therapy. In addition, new methods, including genomics and metagenomics, are being employed for the discovery of new enzymes from microbes. This book brings all of these topics together, representing the first resource on how to solve problems in bioremediation. Provides the most novel approaches in enzyme studies Gives insights in real-time enzymology that are correlated with bioremediation Serves as a valuable resource on the use of genomes, transcriptomes and proteomes with bioremediation Refers to enzymes as diagnostic tools

Chemical Biology of Glycoproteins

Chemical Biology of Glycoproteins Book
Author : Zhongping Tan,Lai-Xi Wang
Publisher : Royal Society of Chemistry
Release : 2017-03-27
ISBN : 1782623337
Language : En, Es, Fr & De

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Book Description :

Glycans play a vital role in modulating protein structure and function from involvement in protein folding, solubility and stability to regulation of tissue distribution, recognition specificity, and biological activity. They can act as both positive and negative regulators of protein function, providing an additional level of control with respect to genetic and environmental conditions. Due to the complexity of glycosylated protein forms, elucidating structural and functional information has been challenging task for researchers but recent development of chemical biology-based tools and techniques is bridging these knowledge gaps. This book provides a thorough review of the current state of glycoprotein chemical biology, describing the development and application of glycoprotein and glycan synthesis technologies for understanding and manipulating protein glycosylation.