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Essential Pharmacokinetics

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Essential Pharmacokinetics

Essential Pharmacokinetics Book
Author : Thorsteinn Loftsson
Publisher : Academic Press
Release : 2015-03-25
ISBN : 0128014911
Language : En, Es, Fr & De

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Book Description :

Essential Pharmacokinetics: A Primer for Pharmaceutical Scientists is an introduction to the concepts of pharmacokinetics intended for graduate students and new researchers working in the pharmaceutical sciences. This book describes the mathematics used in the mammillary model as well as the application of pharmacokinetics to pharmaceutical product development, and is useful as both a self-study and classroom resource. Content coverage includes detailed discussions of common models and important pharmacokinetic concepts such as biological half-life, clearance, excretion, multiple dosage regimens and more. Numerous equations, practical examples and figures are incorporated to clearly illustrate the theoretical background of pharmacokinetic behavior of drugs and excipients. Shows how to apply basic pharmacokinetic methods to evaluate drugs, excipients and drug products Uses guided practice questions, mathematical concepts and real-world examples for self-assessment and retention purposes Illustrates how to write and evaluate drug registration files

Handbook of Essential Pharmacokinetics Pharmacodynamics and Drug Metabolism for Industrial Scientists

Handbook of Essential Pharmacokinetics  Pharmacodynamics and Drug Metabolism for Industrial Scientists Book
Author : Younggil Kwon
Publisher : Springer Science & Business Media
Release : 2007-05-08
ISBN : 0306468204
Language : En, Es, Fr & De

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Book Description :

In the pharmaceutical industry, the incorporation of the disciplines of pharma- kinetics, pharmacodynamics, and drug metabolism (PK/PD/DM) into various drug development processes has been recognized to be extremely important for approp- ate compound selection and optimization. During discovery phases, the identifi- tion of the critical PK/PD/DM issues of new compounds plays an essential role in understanding their pharmacological profiles and structure-activity relationships. Owing to recent progress in analytical chemistry, a large number of compounds can be screened for their PK/PD/DM properties within a relatively short period of time. During development phases as well, the toxicology and clinical study designs and trials of a compound should be based on a thorough understanding of its PK/PD/DM properties. During my time as an industrial scientist, I realized that a reference work designed for practical industrial applications of PK/PD/DM could be a very valuable tool for researchers not only in the pharmacokinetics and drug metabolism departments, but also for other discovery and development groups in pharmaceutical companies. This book is designed specifically for industrial scientists, laboratory assistants, and managers who are involved in PK/PD/DM-related areas. It consists of thirteen chapters, each of which deals with a particular PK/PD/DM issue and its industrial applications. Chapters 3 and 12 in particular address recent topics on higher throughput in vivo exposure screening and the prediction of pharmacokinetics in humans, respectively. Chapter 8 covers essential information on drug metabolism for industrial scientists.

Basic Pharmacokinetics

Basic Pharmacokinetics Book
Author : Mohsen A. Hedaya
Publisher : CRC Press
Release : 2007-04-23
ISBN : 1420046721
Language : En, Es, Fr & De

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Book Description :

This volume is a self-instructional computer-assisted medium for active learning. Indeed, the tutorial materials included in the accompanying compact disk have received an award from the American Association of Colleges of Pharmacy for innovation in teaching. This volume and its companion CD are intended for students and practitioners in the health professions who need to comprehend the concepts and principles related to how the body absorbs, distributes, metabolizes, and excretes drugs. "...The author's reliance on active learning, his use of examples illustrating important pharmacokinetic principles, and particularly the thoughtful simulation tools he has developed make this text and its companion CD an extremely effective and enjoyable introduction to the field of pharmacokinetics." From the Foreword, Ronald J. Sawchuk Minneapolis, Minnesota Pharmacokinetics has become an essential component of all the processes involved in drug development, discovery, and preclinical evaluation, as well as with the clinical use of drugs. While this has led to the development of many highly complex techniques, basic pharmacokinetic concepts remain the backbone of all these new developments. Consequently, a thorough understanding of the basic concepts is essential before one can tackle the more involved and applied areas of pharmacokinetics. Basic Pharmacokinetics consists of two parts: textual printed materials and highly interactive computer-based presentations. Together, these provide a useful combination that makes it easy to grasp basic principles. The computer-based information is presented in a self-instructional format, which introduces concepts, utilizing highly interactive graphical presentations and simulations. It visualizes the interplay between the different pharmacokinetic parameters, observing how the change in one or more of these parameters impacts the drug concentration-time profile in the body. Uniquely and carefully designed, the learning modules in the CD closely support and complement the text, providing the learner with an opportunity to reinforce his or her understanding of the principles presented.

Applied Biopharmaceutics and Pharmacokinetics

Applied Biopharmaceutics and Pharmacokinetics Book
Author : Leon Shargel,Andrew B. C. Yu
Publisher : McGraw-Hill/Appleton & Lange
Release : 1993
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

The third edition of this introductory text covers the factors which influence the release of the drug from the drug product and how the body handles the drug. A stronger focus has been placed on the basics with clear explanations and illustrated examples. There is also more information on statistics and population pharmacokinetics and new chapters on drug distribution, computer applications, enzyme kinetics and pharmacokinetics models.

Basic Pharmacokinetics and Pharmacodynamics

Basic Pharmacokinetics and Pharmacodynamics Book
Author : Sara E. Rosenbaum
Publisher : John Wiley & Sons
Release : 2016-12-27
ISBN : 1119143152
Language : En, Es, Fr & De

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Book Description :

Updated with new chapters and topics, this book provides a comprehensive description of all essential topics in contemporary pharmacokinetics and pharmacodynamics. It also features interactive computer simulations for students to experiment and observe PK/PD models in action. • Presents the essentials of pharmacokinetics and pharmacodynamics in a clear and progressive manner • Helps students better appreciate important concepts and gain a greater understanding of the mechanism of action of drugs by reinforcing practical applications in both the book and the computer modules • Features interactive computer simulations, available online through a companion website at: https://web.uri.edu/pharmacy/research/rosenbaum/sims/ • Adds new chapters on physiologically based pharmacokinetic models, predicting drug-drug interactions, and pharmacogenetics while also strengthening original chapters to better prepare students for more advanced applications • Reviews of the 1st edition: “This is an ideal textbook for those starting out … and also for use as a reference book …." (International Society for the Study of Xenobiotics) and “I could recommend Rosenbaum’s book for pharmacology students because it is written from a perspective of drug action . . . Overall, this is a well-written introduction to PK/PD …. “ (British Toxicology Society Newsletter)

Applied Biopharmaceutics Pharmacokinetics

Applied Biopharmaceutics   Pharmacokinetics Book
Author : Leon Shargel,Andrew B. C. Yu
Publisher : McGraw-Hill/Appleton & Lange
Release : 1999
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

This new edition emphasizes the application and understanding of basic theoretical principles of biopharmaceutics and pharmacokinetics. Now with a second highlight color, this book helps students gain skills in problem solving and includes examples and practice problems and solutions.

Basic Pharmacokinetics Second Edition

Basic Pharmacokinetics  Second Edition Book
Author : Mohsen A. Hedaya
Publisher : CRC Press
Release : 2012-02-09
ISBN : 1439850739
Language : En, Es, Fr & De

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Book Description :

Knowledge of pharmacokinetics is critical to understanding the absorption, distribution, metabolism, and excretion of drugs. It is therefore vital to those engaged in the discovery, development, and preclinical and clinical evaluation of drugs, as well as practitioners involved in the clinical use of drugs. Using different approaches accessible to a wide variety of readers, Basic Pharmacokinetics: Second Edition demonstrates the quantitative pharmacokinetic relations and the interplay between pharmacokinetic parameters. After a basic introduction to pharmacokinetics and its related fields, the book examines: Mathematical operations commonly used in pharmacokinetics Drug distribution and clearance and how they affect the rate of drug elimination after a single dose Factors affecting drug absorption following extravascular drug administration, the rate and extent of drug absorption, and drug bioequivalence The steady-state concept during constant rate intravenous infusion and during multiple drug administration Renal drug elimination, drug metabolism, multicompartment models, nonlinear pharmacokinetics, and drug administration by intermittent intravenous infusion Pharmacokinetic-pharmacodynamic modeling, noncompartmental pharmacokinetic data analysis, clearance concept from the physiological point of view, and physiological modeling Clinical applications of pharmacokinetics, including therapeutic drug monitoring, drug pharmacokinetics in special populations, pharmacokinetic drug-drug interactions, pharmacogenomics, and applications of computers in pharmacokinetics Accompanying the book is a CD-ROM with self-instructional tutorials and pharmacokinetic and pharmacokinetic-pharmacodynamic simulations, allowing visualization of concepts for enhanced comprehension. This learning tool received an award from the American Association of Colleges of Pharmacy for innovation in teaching, making it a valuable supplement to this essential text.

Essentials of Biopharmaceutics and Pharmacokinetics E Book

Essentials of Biopharmaceutics and Pharmacokinetics   E Book Book
Author : Ashutosh Kar
Publisher : Elsevier Health Sciences
Release : 2010-09-15
ISBN : 813123262X
Language : En, Es, Fr & De

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Book Description :

Essentials of Biopharmaceutics and Pharmacokinetics Kar’s Essentials of Biopharmaceutics and Pharmacokinetics deals with how a drug exerts its action in the human body through the fundamentals of absorption, distribution, metabolism and excretion. The book adopts a growth-oriented format and design that is developed systematically and methodically. The book interrelates five different sections: Section 1 Biopharmaceutics and Pharmacokinetics: What Do They Mean? Section 2 Biopharmaceutics Section 3 Pharmacokinetics Section 4 Clinical Pharmacokinetics Section 5 Bioavailability and Bioequivalence Each section starts with a basic theory and fields of application, focuses on model-independent pharmacokinetic analyses, expatiates various biopharmaceutical aspects of dosage form and evaluation, provides an altogether new approach in understanding both dosage regimen design and individualization, and explains modification in drug molecules related to the pharmacokinetics. Undoubtedly, the unique blend of fundamental principles and latest breakthroughs in the field will certainly provide sufficient subject matter to the students of pharmacy, pharmacology, medicinal chemistry scientists, who need a simple as well as detailed introduction in theory and application.

Handbook of Basic Pharmacokinetics Including Clinical Applications

Handbook of Basic Pharmacokinetics   Including Clinical Applications Book
Author : Wolfgang A. Ritschel
Publisher : Unknown
Release : 1986
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Handbook of Basic Pharmacokinetics Including Clinical Applications book written by Wolfgang A. Ritschel, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Applied Pharmacokinetics

Applied Pharmacokinetics Book
Author : William E. Evans,Jerome J. Schentag,William J. Jusko
Publisher : Applied Therapeutics, Incorporated
Release : 1992
ISBN : 9780915486151
Language : En, Es, Fr & De

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Book Description :

The Third Edition of Applied Pharmacokinetics remains the gold standard by which all other clinical pharmacokinetics texts are measured. Written by leading pharmacokinetics researchers and practitioners, this book is the most advanced kinetics reference available. All chapters have been extensively updated or completely rewritten for this edition, and six new chapters have been added on pharmacodynamics, pharmacogenetics, pharmacokinetic considerations in the obese, dietary influences on drug disposition, zidovudine, and corticosteroids. Each chapter is tightly focused on the most important concepts and issues. Chapters on specific drugs are organized in a consistent format for quick, easy information retrieval. Major subheadings include Clinical Pharmacokinetics, Pharmacodynamics, Clinical Application of Pharmacokinetic Data, Analytical Methods, and Prospectus.

Handbook of Essential Psychopharmacology

Handbook of Essential Psychopharmacology Book
Author : Ronald W. Pies
Publisher : Amer Psychiatric Pub
Release : 1998
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Because of continuous new developments in drug research and practice, psychopharmacology is a subject in constant change. As the number of published research and efficacy studies, theoretical papers, and case reports continues to increase, busy clinicians, residents, and teachers must struggle constantly to keep current with this explosion of information. Fortunately, there is a source that can help them learn and retain the basics of psychopharmacology. Loaded with many special features, the "Handbook of Essential Psychopharmacology" is both a handy clinical reference for experienced clinicians and an ideal teaching tool and manual for residents, especially those preparing for the psychiatry board examinations. This useful guide provides busy residents and clinicians with a quick, current, and accessible guide to basic facts about psychotropic drugs, including dosage, indications, and drug interactions. Each chapter summarizes information about one of the four major drug classes: antidepressants, antipsychotics, anxiolytics/sedative-hypnotics, and mood stabilizers. Each chapter provides a brief overview; a wealth of tables and graphs for quick clinical consultation; a unique question and answer section and clinical vignettes designed to test the reader's comprehension; and a comprehensive reference list. Packed with essential information and many useful charts and graphs, the "Handbook of Essential Psychopharmacology" is an essential starting point in psychopharmacology for residents and experienced clinicians alike.

Management of Essential Hypertension

Management of Essential Hypertension Book
Author : Francis Gilbert McMahon
Publisher : Blackwell/Futura
Release : 1984
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Management of Essential Hypertension book written by Francis Gilbert McMahon, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Essentials of Pharmacokinetics and Pharmacodynamics

Essentials of Pharmacokinetics and Pharmacodynamics Book
Author : Thomas N. Tozer,Malcolm Rowland
Publisher : LWW
Release : 2015-09-01
ISBN : 9781451194425
Language : En, Es, Fr & De

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Book Description :

This unique text helps students and healthcare professionals master the fundamentals of pharmacokinetics and pharmacodynamics. Written by distinguished international experts, it provides readers with an introduction to the basic principles underlying the establishment and individualization of dosage regimens and their optimal use in drug therapy. Up-to-date examples featuring currently prescribed drugs illustrate how pharmacokinetics and pharmacodynamics relate to contemporary drug therapy. Study problems at the end of each chapter help students and professionals gain a firm grasp of the material covered within the text.

Pharmacokinetics

Pharmacokinetics Book
Author : Milo Gibaldi,Donald Perrier
Publisher : Unknown
Release : 1975
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Pharmacokinetics book written by Milo Gibaldi,Donald Perrier, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Essentials of Pharmacology

Essentials of Pharmacology Book
Author : John A. Bevan,Jeremy H. Thompson
Publisher : Harpercollins
Release : 1983
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Essentials of Pharmacology book written by John A. Bevan,Jeremy H. Thompson, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Calcium in Essential Hypertension

Calcium in Essential Hypertension Book
Author : Kyuzo Aoki,Edward D. Frohlich
Publisher : Unknown
Release : 1989
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Calcium in Essential Hypertension book written by Kyuzo Aoki,Edward D. Frohlich, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

The Pharmacokinetics of Prazosin

The Pharmacokinetics of Prazosin Book
Author : Robert A. Baughman
Publisher : Unknown
Release : 1982
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download The Pharmacokinetics of Prazosin book written by Robert A. Baughman, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Abstracts

Abstracts Book
Author : American Pharmaceutical Association
Publisher : Unknown
Release : 1986
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Abstracts book written by American Pharmaceutical Association, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Psychiatry Essentials

Psychiatry Essentials Book
Author : Alex Kolevzon,Daphne Simeon
Publisher : Unknown
Release : 2002
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Concise outline-oriented coverage of psychiatry covers all the information the medical student needs for clinical rotations and for preparing for the USMLE. For each psychiatric disorder, first section (The Basics) identifies and describes the disorder and its treatment (ideal for the first weeks of the rotation). The second section (Essential Features) summarizes all essential features of the disorder (will help you answer most exam questions and excel on the ward). The third section (Depth and Detail) covers more in-depth material, including high-yield details in epidemiology, etiology, diagnosis, course and prognosis, treatment, and differential (for study immediately before the boards). Concise coverage of the medical school curriculum in psychiatry Unique organization allows student to review either just The Basics or to go deeper into the subject area by reviewing Essential Features and then Depth and Detail Attractive page layout for easy studying and review Contains the latest DMS-4-TR material Extensive coverage of Psychopharmacology

Biopharmaceutics and Clinical Pharmacokinetics

Biopharmaceutics and Clinical Pharmacokinetics Book
Author : Milo Gibaldi
Publisher : Lippincott Williams & Wilkins
Release : 1991
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

This updated introduction to the clinical applications of pharmacokinetics looks at gastrointestinal absorption, prolonged release medication, and drug disposition. The effects of disease, weight, age, sex and genetic factors on pharmacokinetic variability and drug response are detailed. Bioequivalence and regulatory considerations for generic drug.