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Epigenetics Of Chronic Pain

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Epigenetics of Chronic Pain

Epigenetics of Chronic Pain Book
Author : Anonim
Publisher : Academic Press
Release : 2018-10-29
ISBN : 0128140712
Language : En, Es, Fr & De

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Book Description :

Epigenetics of Chronic Pain, Volume Nine, presents comprehensive information on the role of epigenetics in chronic pain sensitivity, providing a detailed, but accessible, view of the field from basic principles, to clinical application. Leading international researchers discuss essential mechanisms of chronic pain epigenetics, including the molecular processes of chromatin remodeling, histone modifications, and the microRNAs and noncoding RNAs involved in regulating genes tied to pain sensitivity. The influence of epigenetics in inflammatory, neuropathic, visceral and other pain models is examined, with data derived from epigenetic studies on peripheral and central mechanisms of pain sensitivity in animal models and clinical cases studies. The studies and case examples cited highlight therapeutic pathways of significance and next steps for researchers to develop epigenetic-based treatments for chronic pain. In recent years, epigenetic regulation of gene expression has been shown to play a central role in managing human pain sensitivity. Findings show that expression of many genes critical to increases or decreases in pain sensitivity are indeed regulated by DNA methylation and its enzymes, histone-involved chromatin remodeling, and noncoding RNAs, mainly microRNAs. Compiles all known information on epigenetic regulation of chronic pain in one volume Covers the basic functionality of epigenetic mechanisms involved in pain management, applications of recent research in understanding different types of chronic pain, and pathways for developing therapeutics Leading international researchers from across academia, clinical settings, and the pharmaceutical industry discuss epigenetics in inflammatory, neuropathic, visceral, and other pain models in-depth Enables clinicians, researchers, and pharmacologists to better understand and treat chronic pain

Exam Prep for Epigenetics of Chronic Pain

Exam Prep for  Epigenetics of Chronic Pain Book
Author : Anonim
Publisher : Unknown
Release : 2021-04-16
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Exam Prep for Epigenetics of Chronic Pain book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Overlapping Pain and Psychiatric Syndromes

Overlapping Pain and Psychiatric Syndromes Book
Author : Mario Incayawar,Sioui Maldonado Bouchard,Michael R. Clark
Publisher : Oxford University Press, USA
Release : 2020-09-09
ISBN : 0190248254
Language : En, Es, Fr & De

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Book Description :

This book describes the complex and striking relationships between pain and psychiatric disorders, offering an in-depth review of the challenging and neglected intersection between pain medicine and psychiatry.

Chronic Pain New Insights for the Healthcare Professional 2013 Edition

Chronic Pain  New Insights for the Healthcare Professional  2013 Edition Book
Author : Anonim
Publisher : ScholarlyEditions
Release : 2013-07-22
ISBN : 1481664069
Language : En, Es, Fr & De

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Book Description :

Chronic Pain: New Insights for the Healthcare Professional: 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about Additional Research. The editors have built Chronic Pain: New Insights for the Healthcare Professional: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Additional Research in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Chronic Pain: New Insights for the Healthcare Professional: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Role of Epigenetic Modification of Gene Expression in Chronic Pain

Role of Epigenetic Modification of Gene Expression in Chronic Pain Book
Author : 謝明君
Publisher : Unknown
Release : 2018
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Role of Epigenetic Modification of Gene Expression in Chronic Pain book written by 謝明君, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Translating Epigenetics to the Clinic

Translating Epigenetics to the Clinic Book
Author : Jeffrey Laurence
Publisher : Academic Press
Release : 2016-12-30
ISBN : 0128006129
Language : En, Es, Fr & De

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Book Description :

Translating Epigenetics to the Clinic reviews current methodological tools and experimental approaches used by leading translational researchers seeking to use epigenetics as a clinical model. It organizes epigenetics into disease treatment areas with a major focus on oncology, and with much coverage of pervasive treatment categories such as diabetes, as well as the ‘diseases of modernity’—including pharmacological addiction, dementia, and ageing. Pedagogically, the work concentrates on the latest knowledge, laboratory techniques, and experimental approaches used by translational research leaders in this field. The book promotes cross-disciplinary communication between the sub-specialties of medicine. In common with the rest of the books in Translational Medicine, the book remains unified in theme by emphasizing recent innovations, critical barriers to progress, and the new tools being used to overcome them. Also includes specific areas of research that require additional study to advance the field as a whole. Encompasses the latest innovations and tools being used to apply epigenetics in the lab and clinic Features extensive pedagogical updates aiming to improve the education of translational researchers in this field Offers a transdisciplinary approach to support cross-fertilization between different sub-specialties of medicine

The Pain Epidemic

The Pain Epidemic Book
Author : Don Goldenberg
Publisher : Rowman & Littlefield Publishers
Release : 2020-10-07
ISBN : 1538138360
Language : En, Es, Fr & De

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Book Description :

Internationally-recognized pain expert Don Goldenberg helps readers better understand the intricacies of chronic pain through the lens of personal stories, including his own. One out of three Americans lives with chronic pain. Pain is the number one reason we seek medical care and accounts for 40% of doctor visits. Chronic pain is the most common cause of work loss world-wide. The yearly cost of chronic pain in the United States is between $560-$630 billion, higher than that of heart disease, diabetes and cancer combined. Despite this, physicians and the public are woefully ill-informed about chronic pain. The litany of self-help books available to the public are largely misleading, quick-fix, junk-science. Although there is a major push to better inform primary health-care providers on chronic pain, they have been provided no authoritative treatment of the subject. The Pain Epidemic provides the latest medical information and pathways to better understanding and treatment of chronic pain. Dr. Don Goldenberg, an internationally known expert on pain, here discusses such hot topics as the opioid epidemic, mind/body interactions in chronic pain, and gender bias, as well as the role of cannabis and new potential pain treatment. Interested readers will come away with not only a better understanding of the pain epidemic but of pain itself.

Comprehensive Medicinal Chemistry II Vol 8

Comprehensive Medicinal Chemistry II  Vol 8 Book
Author : John B Taylor,David J Triggle
Publisher : Elsevier Science Limited
Release : 2007
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Presents a different view of medicinal chemistry through personal accounts by eminent scientists describing their lifetime experiences in the field. Also illustrates 14 case studies of successful drug discovery and development. * valuable content available May 2009 as an individual volume * separate volumes will appeal to a wider chemistry, biochemistry and medicinal audience * priced for individual researcher as well as library purchase

Neurobiological Mechanisms Involved in Chronic Pain

Neurobiological Mechanisms Involved in Chronic Pain Book
Author : Roger Negrete Buela
Publisher : Unknown
Release : 2018
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Chronic pain is currently a major clinical issue that represents huge economic and social burdens. Chronic pain treatment currently available presents limited efficacy and significant side effects. One of the reasons for this lack of effective therapeutic approaches is the insufficient knowledge of the mechanisms involved in the development and maintenance of chronic pain and pain-related comorbidities, such as emotional and cognitive manifestations. These associated symptoms negatively affect the life quality of the patients. In our study, we have first validated the different outcomes to measure the nociceptive, emotional and cognitive components of chronic neuropathic pain in mice, and the effects of repeated treatment with pregabalin on these manifestations. We have then identified the influence of different personality traits in the individual variability to chronic neuropathic pain perception in mice, and the emotional and cognitive manifestations associated to this chronic pain using different behavioural, electrophysiological and genetic techniques. The opioid system is a crucial therapeutic target for the treatment of chronic pain, despite the multiple side effects associated to opioid compounds. Thus, we have evaluated the involvement of specific components of the endogenous opioid system in the behavioural, emotional, cognitive, neurochemical and epigenetic manifestations of chronic osteoarthritis pain in mice. We have identified the endogenous dynorphin /  opioid receptor system as an interesting pharmacological target for the treatment of the different manifestations of chronic pain.

Principles of Rehabilitation Medicine

Principles of Rehabilitation Medicine Book
Author : Raj Mitra
Publisher : McGraw Hill Professional
Release : 2018-10-12
ISBN : 0071793348
Language : En, Es, Fr & De

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Book Description :

A high-yield board review and quick reference for Rehabilitation Medicine Rehabilitation Medicine Rapid Review is written primarily for Physical Medicine and Rehabilitation residents preparing for their board exams, and is also an excellent reference for practicing physicians who need a primer on this rapidly growing specialty. With content organized around the American board of Physical Medicine and Rehabilitation core curriculum, this powerful review is enhanced by more than 500 review questions and answers, and concise, bulleted, high-yield text. Readers will find quick answers to common and infrequent issues encountered in rehabilitation medicine

Chronic Pleasure

Chronic Pleasure Book
Author : Karen Lorre
Publisher : Morgan James Publishing
Release : 2019-09-03
ISBN : 1642795127
Language : En, Es, Fr & De

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Book Description :

Chronic Pleasure helps readers who are overwhelmed easily, incessantly fatigued, and constantly in pain by providing them with the tools to feel vibrant, more energized, and happier. After struggling with chronic pain and incessant fatigue, Karen Lorre used her knowledge of the Law of Attraction and the mind-body connection to live with vibrant, youthful energy, and a tranquil mind. In Chronic Pleasure, Karen covers all the steps she discovered that allow her life to be easier, richer, happier, more intuitive, and more fun. She helps readers discover the secrets to wake up feeling good and keep feeling good all day by showing them the “missing piece” that gives boundless energy and relief from pain. Chronic Pleasure is for those who are ready to tap into the vibrant energy and chronic pleasure that one’s body and emotions crave.

Functional Pain Syndromes

Functional Pain Syndromes Book
Author : Emeran A. Mayer,M. Catherine Bushnell
Publisher : International Assn for the Study of Pain
Release : 2009
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

"This book reviews the pathophysiology of functional pain disorders, including irritable bowel syndrome, fibromyalgia, vulvodynia, and interstitial cystitis, and considers the relationship of these disorders with one another and with anxiety, depression,post-traumatic stress disorder, and chronic fatigue syndrome. The authors also describe treatment options, including antidepressants and psychological therapies"--Provided by publisher.

Social Pain

Social Pain Book
Author : Geoff MacDonald,Lauri A. Jensen-Campbell
Publisher : Amer Psychological Assn
Release : 2011
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Social pain is the experience of pain as a result of interpersonal rejection or loss, such as rejection from a social group, bullying, or the loss of a loved one. Research now shows that social pain results from the activation of certain components in physical pain systems. Although social, clinical, health, and developmental psychologists have each explored aspects of social pain, recent work from the neurosciences provides a coherent, unifying framework for integrative research. This edited volume provides the first comprehensive, multidisciplinary exploration of social pain. Part I examines the subject from a neuroscience perspective, outlining the evolutionary basis of social pain and tracing the genetic, neurological, and physiological underpinnings of the phenomenon. Part II explores the implications of social pain for functioning in interpersonal relationships; contributions examine the influence of painkillers on social emotions, the ability to relive past social hurts, and the relation of social pain to experiences of intimacy. Part III examines social pain from a biopsychosocial perspective in its consideration of the health implications of social pain, outlining the role of stress in social pain and the potential long-term health consequences of bullying. The book concludes with an integrative review of these diverse perspectives.

Dissertation Abstracts International

Dissertation Abstracts International Book
Author : Anonim
Publisher : Unknown
Release : 2006
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Dissertation Abstracts International book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Public Library Core Collection

Public Library Core Collection Book
Author : John Greenfieldt,Patrice Bartell
Publisher : Hw Wilson Company
Release : 2008
ISBN : 9780824210946
Language : En, Es, Fr & De

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Book Description :

Wilson's Public Library Core Collection: Nonfiction (13th Edition, 2008) recommends reference and nonfiction books for the general adult audience. It is a guide to over 9,000 books (over 6,500 titles are new to this edition), plus review sources and other professional aids for librarians and media specialists. Acquisitions librarians, reference librarians and cataloguers can all use this reliable guide to building and maintaining a well-rounded collection of the most highly recommended reference and nonfiction books for adults. All titles are selected by librarians, editors, advisors, and nominators-all of them experts in public library services. The collection is a valuable tool for collection development and maintenance, reader's advisory, weeding your collection, and curriculum support. Richly enhanced records provide a wealth of useful information. All entries include complete bibliographic data as well as price, subject headings, annotations, grade level, Dewey classification, cover art, and quotations from reviews. Many entries also list awards, best-book lists, and starred reviews. Save Time: Efficiently organised and includes ""Starred"" titles Save Money: Allocate your resources to the best materials available Stay Relevant: Discover the best in important, contemporary categories Complete Coverage: Includes recommendations on periodicals and electronic resources, too Four-Year Subscription This Core Collection was originally sold as a four-year subscription. The core edition, published in 2008, delivers a library-bound volume with an extensive, selective list of recommended books. From 2009 to 2011 Wilson published extensive paperback supplements to the 2008 edition. A new cycle of materials will begin in 2012. However, the 2008 to 2011 materials are currently available. Buyers of them will receive all these materials immediately. All four years are only $420. Uniquely Valuable There is nothing quite like Wilson Core Collections. The accumulated expertise of our selectors, and the unquestioned reputation of these collections, is invaluable. Wilson Core Collections are universally recognised as impartial and expert aids to collection development that assist and reinforce the judgement of librarians everywhere. Selection to a Wilson Core Collection is strong support to any challenged purchase. Contemporary Relevance This Core Collection includes broad updates in the areas of crafts; terrorism, and international security; environment and global warming; diseases and medicine; and religion, plus other contemporary topics that keep the library's collection as current as today's headlines. Other Key Features Classified Catalogue - A list arranged by Dewey Decimal Classification, with complete cataloguing information for each book. Author, Title, Subject and Analytical Index - An in-depth key to the information in Classified Catalogue-including author and title analytics for works contained in anthologies and collections. Richly enhanced records provide complete bibliographic data, price, subject headings, descriptive annotations, grade level, Dewey classification, evaluative quotations from a review, when available. Listing works published in the United States, or published in Canada or the United Kingdom and distributed in the United States, Public Library Core Collection: Nonfiction features extensive revisions in the areas of health, science and technology, personal finance, sports, cooking and gardening, and handicrafts. Biography, poetry and literary criticism continue to receive comprehensive treatment. Reference works in all subject fields are included.

CURRENT Diagnosis Treatment in Family Medicine 5th Edition

CURRENT Diagnosis   Treatment in Family Medicine  5th Edition Book
Author : Jeannette E. South-Paul,Samuel C. Matheny,Evelyn L. Lewis
Publisher : McGraw Hill Professional
Release : 2020-07-21
ISBN : 1260134903
Language : En, Es, Fr & De

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Book Description :

Publisher's Note: Products purchased from Third Party sellers are not guaranteed by the publisher for quality, authenticity, or access to any online entitlements included with the product. Provide continuous, comprehensive care of patients throughout their lifetimes with this evidence-based guide An easy-to-use guide to the diagnosis, treatment, and management of the full range of clinical conditions seen in primary care NEW content includes coverage of genetics and precision medicine use in family medicine, telehealth in family medicine, CTE and sports injuries, Zika, the opioid epidemic, Hepatitis C, expansion of the HIV section, veteran's health and PTSD, and more The leading resource for USMLE Step 3 review, board certification and maintenance or recertification Essential for primary care trainees, practicing physicians, advanced practice nurses, and physician assistants Features Organized according to the developmental lifespan, beginning with childhood and adolescence and progressing through adulthood and senior years Evidence-based recommendations Conservative and pharmacologic therapies Complementary and alternative therapies when relevant Suggestions for collaborations with other healthcare providers Attention to the mental and behavioral health of patients as solitary as well as comorbid conditions Recognition of impact of illness on the family Patient education information End-of-life issues

Drug Addiction

Drug Addiction Book
Author : Anonim
Publisher : Unknown
Release : 2008
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Drug Addiction book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Nature

Nature Book
Author : Sir Norman Lockyer
Publisher : Unknown
Release : 2008
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Nature book written by Sir Norman Lockyer, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Elucidating Mechanism in Pathological Pain Condition

Elucidating Mechanism in Pathological Pain Condition Book
Author : Ruchi Yadav
Publisher : Unknown
Release : 2017
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Pathological pain is a debilitating condition affecting millions of people worldwide and is poorly treated by conventional therapeutics. In this dissertation, a series of mechanistic studies are presented to identify novel therapeutic strategies to develop analgesic for the treatment of pain. This dissertation comprises four chapters. Chapter one a literature review of the role of neuronal dysfunction in chronic pain conditions. In the chronic pain condition, hyperexcitation of neuronal cells and neuroinflammation are hallmark events in the nociceptive pathway. Homeostasis between excitatory and inhibitory receptor activities is crucial to maintain normal neuronal activities in the central nervous system (CNS). In chapter two we have successfully shown in the paclitaxel-induced neuropathic pain model that local application of GAT-1 transporter activity inhibitors at the spinal enlargement reverses the attenuated GABAergic disinhibition and ameliorates neuropathic pain. Thus, targeting GAT-1 transporters for reversing GABAergic disinhibition in the spinal dorsal horn could be a useful approach for treating paclitaxel-induced neuropathic pain. Tissue and nerve injury produce neuroinflammation which is a critical component, contributing to the genesis of pathological pain. Activation of glial cells, accumulation of proinflammatory cytokines and release of various algesic mediators in the spinal cord produces long-lasting cellular and behavior changes as a consequence of widespread alterations in gene expression profile. Epigenetics mechanism such as post-translation modification of histone tails residues plays important role in various gene activation and suppression. In chapter three we have presented compelling evidence demonstrating global change of enhancer zeste homolog-2 (EZH2) activities and methylation levels of H3K27 in the spinal dorsal horn is associated with glia cells activation and neuroinflammation following nerve injury. Inhibition of EZH2 prevented and attenuated the neuropathic pain condition thus provide compelling evidence that targeting signaling pathways regulating gene expression could prove to be an effective approach for the development of new analgesics for the treatment of neuropathic pain. Lastly, chapter four provides a discussion of pharmacological management of pain with a focus on the remaining challenges in the translation of pain therapeutics.