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Epigenetics Of Cancer Prevention

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Epigenetics of Cancer Prevention

Epigenetics of Cancer Prevention Book
Author : Anupam Bishayee,Deepak Bhatia
Publisher : Academic Press
Release : 2018-11-27
ISBN : 0128125667
Language : En, Es, Fr & De

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Book Description :

Epigenetics of Cancer Prevention, Volume Ten is the first to look at epigenetics and chemoprevention together. Although there is numerous scientific data available on how epigenetics can lead to cancer and how chemoprevention can be beneficial in the treatment of, or improvement of quality of life, together they will set an advanced understanding for the reader in this upcoming field of chemoprevention influencing epigenetics. This book discusses molecular epigenetic targets of natural products, such as green tea polyphenols, curcumin and resveratrol, and organ specific epigenetic targets related to diverse types of cancer, for example prostate, colorectal, breast, lung and skin cancers. Additionally, it encompasses a discussion on research methods and limitations to study epigenetics and epigenomics of chemopreventive drugs and personalized cancer treatment with phytochemicals. The book is ideal for cancer researchers, health care professionals and all individuals who are interested in cancer prevention research and its clinical applications, especially in natural remedies. Lists natural agents, including nutraceuticals, and their effects on normal or tumor genome Addresses various epigenetic systems and mechanisms in the regulation and support of the mammalian genome Discusses how various parts of dietary phytochemicals can influence or modify epigenetic mechanisms in several types of cancer

Epigenetic Mechanisms in Cancer

Epigenetic Mechanisms in Cancer Book
Author : Sabita Saldanha
Publisher : Academic Press
Release : 2017-11-16
ISBN : 0128134607
Language : En, Es, Fr & De

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Book Description :

Epigenetic Mechanisms in Cancer provides a comprehensive analysis of epigenetic signatures that govern disease development, progression and metastasis. Epigenetic signatures dictating tumor etiologies present an opportunity for biomarker identification which has broad potential for improving diagnosis, prognosis, prediction, and risk assessment. This volumes offers a unique evaluation of signature differences in childhood, sex-specific and race-specific cancers, and in doing so broadly illuminates the scope of epigenetic biomarkers in clinical environments. Chapters detail the major epigenetic process in humans consisting of DNA methylation, histone modifications and microRNAs (miRNAs) involved in the initiation, progression and metastasis of tumors. Also delineated are recent technologies such as next generation sequencing that are used to identify epigenetic profiles (primarily methylation analysis) in samples (normal, benign and cancerous) and which are highly important to the analysis of epigenetic outcomes. Offers broad coverage that is applicable to audiences in various area of cancer research - population studies, diagnostics, prognosis, prediction, therapy, risk, etc. Provides critical review analysis of the topics that will clarify and delineate the potential roles of epigenetic signatures in cancer management Covers basic, as well as, clinical areas of epigenetic mechanisms in tumorigenesis Features contributions by leading experts in the field Provides comprehensive coverage of current epigenetic signatures involved in the etiology of various cancers and miRNAs

Environmental Epigenetics

Environmental Epigenetics Book
Author : L. Joseph Su,Tung-chin Chiang
Publisher : Springer
Release : 2015-05-18
ISBN : 1447166787
Language : En, Es, Fr & De

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Book Description :

This book examines the toxicological and health implications of environmental epigenetics and provides knowledge through an interdisciplinary approach. Included in this volume are chapters outlining various environmental risk factors such as phthalates and dietary components, life states such as pregnancy and ageing, hormonal and metabolic considerations and specific disease risks such as cancer cardiovascular diseases and other non-communicable diseases. Environmental Epigenetics imparts integrative knowledge of the science of epigenetics and the issues raised in environmental epidemiology. This book is intended to serve both as a reference compendium on environmental epigenetics for scientists in academia, industry and laboratories and as a textbook for graduate level environmental health courses. Environmental Epigenetics imparts integrative knowledge of the science of epigenetics and the issues raised in environmental epidemiology. This book is intended to serve both as a reference compendium on environmental epigenetics for scientists in academia, industry and laboratories and as a textbook for graduate level environmental health courses.

Cancer Epigenetics for Precision Medicine

Cancer Epigenetics for Precision Medicine Book
Author : Ramona G. Dumitrescu,Mukesh Verma
Publisher : Humana Press
Release : 2018-10-12
ISBN : 9781493987504
Language : En, Es, Fr & De

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Book Description :

This volume discusses certain epigenetic changes recognized in early carcinogenic lesions and different tumors, as well as factors that alter the epigenome and epigenetic profile such as diet, alcohol, immunity, circadian rhythm, and more. The chapters in this book further delve into this field and cover topics such as epigenome-based precision medicine in lung cancer; interplay between genetic and epigenetic changes in breast cancer subtypes; genetic regulation of PDCD1 gene in cancer immunology; and pyrosequencing methylation analysis. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and authoritative, Cancer Epigenetics for Precision Medicine: Methods and Protocols is a valuable resource to help researchers and scientists identify these specific biomarkers and work towards the prevention, diagnosis, and prognosis of different cancers in the future.

Epigenetics and Cancer

Epigenetics and Cancer Book
Author : Anonim
Publisher : Academic Press
Release : 2010-11-23
ISBN : 9780123808653
Language : En, Es, Fr & De

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Book Description :

Genes interact with the environment, experience, and biology of the brain to shape an animal’s behavior. This latest volume in Advances in Genetics, organized according to the most widely used model organisms, describes the latest genetic discoveries in relation to neural circuit development and activity. Explores the latest topics in neural circuits and behavior research in zebrafish, drosophila, C.elegans, and mouse models Includes methods for testing with ethical, legal, and social implications Critically analyzes future prospects

Nutrition and Cancer Prevention

Nutrition and Cancer Prevention Book
Author : Thomas Prates Ong,Fernando Salvador Moreno
Publisher : Royal Society of Chemistry
Release : 2019-12-03
ISBN : 1788013417
Language : En, Es, Fr & De

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Book Description :

Cancer is a major global public health problem. Among different environmental and lifestyle factors contributing to cancer risk, diet is a key one. On the one hand, obesity and increased consumption of red and processed meat, ethanol, sugar and saturated fatty acids are associated with increased cancer risk. On the other hand, consumption of micronutrients such as vitamin D, selenium, zinc, folate and bioactive compounds from fruits and vegetables is associated with decreased risk. Written by an influential, international team of experts, this book presents and discusses current topics on nutrition and cancer prevention. It covers both nutritional influences on different cancers plus specific chapters on the commonly occurring cancers. Nutritional genomics-based studies show that some dietary components modulate carcinogenesis through complex cellular and molecular mechanisms. A better understanding of these different cellular and molecular mechanisms is needed to establish efficient dietary recommendations for cancer prevention. This book will provide such an understanding, serving as an important book for all those working in nutritional health, food science and cancer research.

Epigenetics in Cancer Prevention

Epigenetics in Cancer Prevention Book
Author : Mukesh Verma,Barbara K. Dunn,Asad Umar
Publisher : Unknown
Release : 2003
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

This volume addresses the question of how knowledge of epigenetic phenomena like DNA methylation and acetylation can be applied to early cancer detection and risk assessment. The objectives of the papers include defining the terminology used in epigenetics.

Personalized Epigenetics

Personalized Epigenetics Book
Author : Trygve Tollefsbol
Publisher : Academic Press
Release : 2015-04-28
ISBN : 0128004363
Language : En, Es, Fr & De

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Book Description :

Personalized Epigenetics discusses the core translatability of epigenetics to health management of individuals who have unique variations in their epigenetic signatures that can guide both disorder and disease prevention and therapy. The book details inter-individual variability in the major epigenetic process in humans consisting of DNA methylation, histone modifications, and noncoding RNA, and the diagnostic, prognostic, and therapeutic potential of the field, it also reviews the impact of the environment on epigenetic variations among individuals and the role of pharmacology and drug development in personalized epigenetics. Most importantly, the text covers personalized epigenetics from a disease-oriented perspective, presenting chapters that provide advances in widespread disorders or diseases, including diabetes, cancer, autoimmune disorders, obesity, cardiovascular diseases, neurological disorders, and pain management. Discusses the core translatability of epigenetics to health management of individuals who have unique variations in their epigenetic signatures Details inter-individual variability in the major epigenetic process in humans consisting of DNA methylation, histone modifications, and noncoding RNA, and the consequent diagnostic, prognostic and therapeutic potential of the field Reviews the impact of the environment on epigenetic variations among individuals and the roles of pharmacology and drug development Devotes several chapters to the advances made in widespread disorders or diseases, including diabetes, cancer, autoimmune disorders, obesity, cardiovascular diseases, neurological disorders, and pain management

Cancer Treatment

Cancer Treatment Book
Author : Letícia Rangel
Publisher : BoD – Books on Demand
Release : 2013-05-09
ISBN : 9535110985
Language : En, Es, Fr & De

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Book Description :

Cancer Treatment: Conventional and Innovative Approaches is an attempt to integrate into a book volume the various aspects of cancer treatment, compiling comprehensive reviews written by an international team of experts in the field. The volume is presented in six sections: i) Section 1: Cancer treatment: Conventional and innovative pharmacological approaches; ii) Section 2: Combinatorial strategies to fight cancer: Surgery, radiotherapy, backytherapy, chemotherapy, and hyperthermia; iii) Section 3: The immunotherapy of cancer; iv) Section 4: Multidisciplinarity in cancer therapy: nutrition and beyond; v) Section 5: Supportive care for cancer patients; vi) Section 6: Perspectives in cancer biology and modeling. Ultimately, we hope this book can enlighten important issues involved in the management of cancer, summarizing the state-of-the-art knowledge regarding the disease control and treatment; thus, providing means to improve the overall care of patients that daily battle against this potentially lethal condition.

Epigenetic Epidemiology

Epigenetic Epidemiology Book
Author : Karin B. Michels
Publisher : Springer Science & Business Media
Release : 2012-01-02
ISBN : 9400724950
Language : En, Es, Fr & De

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Book Description :

The exploding field of epigenetics is challenging the dogma of traditional Mendelian inheritance. Epigenetics plays an important role in shaping who we are and contributes to our prospects of health and disease. While early epigenetic research focused on plant and animal models and in vitro experiments, population-based epidemiologic studies increasingly incorporate epigenetic components. The relevance of epigenetic marks, such as DNA methylation, genomic imprinting, and histone modification for disease causation has yet to be fully explored. This book covers the basic concepts of epigenetic epidemiology, discusses challenges in study design, analysis, and interpretation, epigenetic laboratory techniques, the influence of of age and environmental factors on shaping the epigenome, the role of epigenetics in the developmental origins hypothesis, and provides the state of the art on the epigenetic epidemiology of various health conditions including childhood syndromes, cancer, infectious diseases, inflammation and rheumatoid arthritis, asthma, autism and other neurodevelopmental disorders, psychiatric disorders, diabetes, obesity and metabolic disorders, and atherosclerosis. With contributions from: Peter Jones, Jean-Pierre Issa, Gavin Kelsey, Robert Waterland, and many other experts in epigenetics!

Epigenetics in Precision Medicine

Epigenetics in Precision Medicine Book
Author : Jose Luis Garcia-Gimenez
Publisher : Elsevier
Release : 2021-11-22
ISBN : 0323858058
Language : En, Es, Fr & De

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Book Description :

In recent years, knowledge of epigenetic mechanisms underlying disease onset and progression has proven crucial for the development of novel early diagnosis and prognosis biomarkers for patient stratification and precision medicine. Epigenetics in Precision Medicine, a new volume in the Translational Epigenetics series, provides a thorough discussion and overview of current developments in clinical epigenetics with special emphasis on epigenetic biomarkers that can be used for clinical diagnosis, prognosis, patient stratification, and treatment monitoring. Disease types discussed include cancer, metabolic disorders, neurodegenerative diseases, bone disease, and immune-related disorders. The book examines the challenges of advancing epigenetics research and translating findings to the clinic and drug discovery in each of these areas, as well as current solutions; chapter authors discuss how to leverage epigenomic technologies, applications, and tools, such as next-generation sequencing, to discover new epigenetic biomarkers in disease and drug studies. Epigenetics in Precision Medicine focuses on complex epigenetic mechanisms in several pathologies, and explores how epigenetics can power the advance of precision medicine, not only by improving in vitro diagnostic and prognostic tools, but by providing new therapeutic approaches to treat human disease. Provides a thorough grounding in epigenetics-driven precision medicine, with emphasis on developing and implementing early diagnosis and prognosis biomarkers, and supporting patient stratification Empowers researchers and clinicians to incorporate epigenetics in new disease research, drug discovery, and clinical practice Features chapter contributions from international leaders in the field

Emerging Epigenetics in Cancer Chemoprevention by Dietary Phytochemicals

Emerging Epigenetics in Cancer Chemoprevention by Dietary Phytochemicals Book
Author : Chengyue Zhang
Publisher : Unknown
Release : 2017
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Cancer chemoprevention is defined as the strategy to block or slow the onset of premalignant tumors and using relatively nontoxic chemical substance. Recently, accumulating experimental evidence has suggested that epigenetic alterations are involved in cancer development. The scope of epigenetics lies on the molecular interface between genetics and environmental factors; external factors switch genes on and off by influencing how cells read the genes. DNA methylation, histone covalent modification and remodeling, miRNA-mediated gene silencing represent the major mechanisms that play important role in epigenetic control of gene expression. This thesis focused on elucidating the epigenetic mechanisms in cancer prevention by dietary phytochemicals. Nrf2 is a master regulator of the antioxidant response and xenobiotic metabolism through the regulation of a wide range of antioxidant and phase II detoxification genes. The cellular protective role of Nrf2 points its potential as a primary target in chemoprevetion. Our group has reported that within tumor development in the transgenic adenocarcinoma of mouse prostate (TRAMP) model, there is a progressive loss of expression of Nrf2 and its downstream target genes, which is associated CpG hypermethylation in the promoter region. Using TRAMP C1 cells, we demonstrated that sulforaphane is a potent demethylation agent and it restores the epigenetically silenced Nrf2 gene through DNA demethylation. JB6 cells are derived from normal skin epidermis. We found that hypermethylation of Nrf2 promoter also exists in the transformation sensitive JB6 P+ cell line. The epigenetic reactivation of the Nrf2 signaling pathway by Tanshinone IIA could potentially contribute to the attenuation of JB6 P+ cellular transformation under the challenge of TPA, a tumor promoter. On the other hand, histone modification, in particular acetylation of H3K27 residue, is implicated in the transcription activation of pro-survival, pro-proliferative, and pro-inflammatory genes following TPA treatment. Bromodomain and extraterminal domain (BET) proteins function as epigenetic reader that recognizes acetylated histone tails and recruits the transcription machinery. Our study revealed that a small molecule BET inhibitor JQ-1 exerts potent anti-cancer and anti-inflammatory effects by interfering with the core transcriptional program of neoplastic transformation. Last but not least, altered levels of miRNA have been linked to tumor malignancy due to their ability to regulate functional gene expression in carcinogenesis. Using oligonucleotide microarray approach we identified the most affected miRNAs in LNCaP cells. Then we further assessed one potential target of PEITC - miR-194 in prostate cancer cell invasiveness. Collectively, dietary phytochemicals could modulate cellular epigenetic events that in part contribute to the cancer preventive effects. Given that oxidative stress and inflammation reaction are important (micro) environmental factors in malignancy transformation, understanding the role of redox and inflammatory signaling in epigenetic regulation could bring novel insights in cancer prevention.

Epigenetics in Human Disease

Epigenetics in Human Disease Book
Author : Trygve O. Tollefsbol
Publisher : Academic Press
Release : 2012
ISBN : 0123884152
Language : En, Es, Fr & De

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Book Description :

Epigenetics is one of the fastest growing fields of sciences, illuminating studies of human diseases by looking beyond genetic make-up and acknowledging that outside factors play a role in gene expression. The goal of this volume is to highlight those diseases or conditions for which we have advanced knowledge of epigenetic factors such as cancer, autoimmune disorders and aging as well as those that are yielding exciting breakthroughs in epigenetics such as diabetes, neurobiological disorders and cardiovascular disease. Where applicable, attempts are made to not only detail the role of epigenetics in the etiology, progression, diagnosis and prognosis of these diseases, but also novel epigenetic approaches to the treatment of these diseases. Chapters are also presented on human imprinting disorders, respiratory diseases, infectious diseases and gynecological and reproductive diseases. Since epigenetics plays a major role in the aging process, advances in the epigenetics of aging are highly relevant to many age-related human diseases. Therefore, this volume closes with chapters on aging epigenetics and breakthroughs that have been made to delay the aging process through epigenetic approaches. With its translational focus, this book will serve as valuable reference for both basic scientists and clinicians alike. Comprehensive coverage of fundamental and emergent science and clinical usage Side-by-side coverage of the basis of epigenetic diseases and their treatments Evaluation of recent epigenetic clinical breakthroughs

The Genetics of Cancer

The Genetics of Cancer Book
Author : B.A. Ponder,M.J. Waring
Publisher : Springer Science & Business Media
Release : 2012-12-06
ISBN : 9401106770
Language : En, Es, Fr & De

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Book Description :

It has been recognized for almost 200 years that certain families seem to inherit cancer. It is only in the past decade, however, that molecular genetics and epidemiology have combined to define the role of inheritance in cancer more clearly, and to identify some of the genes involved. The causative genes can be tracked through cancer-prone families via genetic linkage and positional cloning. Several of the genes discovered have subsequently been proved to play critical roles in normal growth and development. There are also implications for the families themselves in terms of genetic testing with its attendant dilemmas, if it is not clear that useful action will result. The chapters in The Genetics of Cancer illustrate what has already been achieved and take a critical look at the future directions of this research and its potential clinical applications.

Introduction to Epigenetics

Introduction to Epigenetics Book
Author : Renato Paro,Ueli Grossniklaus,Raffaella Santoro,Anton Wutz
Publisher : Springer Nature
Release : 2021-03-23
ISBN : 3030686701
Language : En, Es, Fr & De

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Book Description :

This open access textbook leads the reader from basic concepts of chromatin structure and function and RNA mechanisms to the understanding of epigenetics, imprinting, regeneration and reprogramming. The textbook treats epigenetic phenomena in animals, as well as plants. Written by four internationally known experts and senior lecturers in this field, it provides a valuable tool for Master- and PhD- students who need to comprehend the principles of epigenetics, or wish to gain a deeper knowledge in this field. After reading this book, the student will: Have an understanding of the basic toolbox of epigenetic regulation Know how genetic and epigenetic information layers are interconnected Be able to explain complex epigenetic phenomena by understanding the structures and principles of the underlying molecular mechanisms Understand how misregulated epigenetic mechanisms can lead to disease

Inflammation Oxidative Stress and Cancer

Inflammation  Oxidative Stress  and Cancer Book
Author : Ah-Ng Tony Kong
Publisher : CRC Press
Release : 2016-04-19
ISBN : 1466503718
Language : En, Es, Fr & De

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Book Description :

Increasing scientific evidence suggests that the majority of diseases including cancer are driven by oxidative stress and inflammation, attributed to environmental factors. These factors either drive genetic mutations or epigenetically modify expression of key regulatory genes. These changes can occur as early as gestational fetal development, and major questions remain as to how dietary/nutritional phytochemical factors biochemically interact with such genetic and epigenetic events. With chapters written by international experts, Inflammation, Oxidative Stress, and Cancer: Dietary Approaches for Cancer Prevention examines the latest developments on the effects of various dietary phytochemicals. Divided into nine sections, the book begins with the basic mechanisms of inflammation/oxidative stress-driven cancer, including an overview of the topic and how to prevent carcinogenesis, the role of obesity in inflammation and cancer, and antioxidant properties of some common dietary phytochemicals. Subsequent sections cover cellular signal transduction, molecular targets, and biomarkers of dietary cancer-preventive phytochemicals, as well as their potential challenges with in vivo absorption and pharmacokinetics. The chapters also examine the cancer-preventive properties of various classes of phytochemicals, including vitamins A, D, and E; omega-3 and omega-6 fatty acids; flavanoids and polyphenols; garlic organosulfur compounds and cruciferous glucosinolates; and selenium, traditional Chinese herbal medicines, and alpha lipoic acid. The final section of the book explores the latest developments on the interactions of dietary phytochemicals through epigenetics and the management of chronic inflammation with nutritional phytochemicals.

Epigenetics of Aging

Epigenetics of Aging Book
Author : Trygve O. Tollefsbol
Publisher : Springer Science & Business Media
Release : 2009-11-11
ISBN : 1441906398
Language : En, Es, Fr & De

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Book Description :

Recent studies have indicated that epigenetic processes may play a major role in both cellular and organismal aging. These epigenetic processes include not only DNA methylation and histone modifications, but also extend to many other epigenetic mediators such as the polycomb group proteins, chromosomal position effects, and noncoding RNA. The topics of this book range from fundamental changes in DNA methylation in aging to the most recent research on intervention into epigenetic modifications to modulate the aging process. The major topics of epigenetics and aging covered in this book are: 1) DNA methylation and histone modifications in aging; 2) Other epigenetic processes and aging; 3) Impact of epigenetics on aging; 4) Epigenetics of age-related diseases; 5) Epigenetic interventions and aging: and 6) Future directions in epigenetic aging research. The most studied of epigenetic processes, DNA methylation, has been associated with cellular aging and aging of organisms for many years. It is now apparent that both global and gene-specific alterations occur not only in DNA methylation during aging, but also in several histone alterations. Many epigenetic alterations can have an impact on aging processes such as stem cell aging, control of telomerase, modifications of telomeres, and epigenetic drift can impact the aging process as evident in the recent studies of aging monozygotic twins. Numerous age-related diseases are affected by epigenetic mechanisms. For example, recent studies have shown that DNA methylation is altered in Alzheimer’s disease and autoimmunity. Other prevalent diseases that have been associated with age-related epigenetic changes include cancer and diabetes. Paternal age and epigenetic changes appear to have an effect on schizophrenia and epigenetic silencing has been associated with several of the progeroid syndromes of premature aging. Moreover, the impact of dietary or drug intervention into epigenetic processes as they affect normal aging or age-related diseases is becoming increasingly feasible.

Epigenetic Therapy of Cancer

Epigenetic Therapy of Cancer Book
Author : Michael Lübbert,Peter A. Jones
Publisher : Springer Science & Business Media
Release : 2013-12-12
ISBN : 3642384048
Language : En, Es, Fr & De

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Book Description :

The growing knowledge about disturbances of epigenetic gene regulation in hematopoietic stem cell disorders is now being translated into treatment approaches that target the epigenetic defects pharmacologically. This book first presents the latest evidence regarding the epigenetic regulation of hematopoietic stem cell differentiation and hemoglobin production. The significance of DNA methylation abnormalities in hematopoietic disorders and of epigenetic disturbances in lung cancer and other solid tumors is then discussed. A major part of the book, however, relates specifically to the translation of basic research and drug development to clinical applications, and in this context both present and future clinical strategies are considered. Individual chapters are devoted to the use of DNA hypomethylating agents and chromatin-modifying agents, and the treatment of hematologic malignancies and solid tumors by means of epigenetic agents is discussed in detail.

Gynaecological Malignancies

Gynaecological Malignancies Book
Author : Gwo Yaw Ho,Sophia Frentzas
Publisher : BoD – Books on Demand
Release : 2020-06-17
ISBN : 183880305X
Language : En, Es, Fr & De

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Book Description :

“Gynaecological Malignancies - Updates and Advances” aims to present a review of the significant advances in the understanding and management of gynaecological malignancies. Major areas of importance in this field will be covered, incorporating new knowledge that has arisen due to the advancements in molecular techniques and the ability to correlate these molecular changes with clinical behaviour of gynaecologic tumours. The therapeutic implications of molecular subtyping to match appropriate therapies and the appreciation of the use of up to date radiotherapy techniques will be explored.

Molecular mechanisms and physiology of disease

Molecular mechanisms and physiology of disease Book
Author : Nilanjana Maulik,Tom Karagiannis
Publisher : Springer
Release : 2014-05-31
ISBN : 1493907069
Language : En, Es, Fr & De

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Book Description :

In a simplified form, epigenetics refers to heritable changes in phenotype that are not due to changes in the underlying DNA sequence. In this book, epigenetic mechanisms of regulation and dysregulation in health and disease are explored in great depth. Detailed chapters on epigenetic processes including DNA methylation and chromatin post-translational modifications including potential interventions with DNA methyltransferase inhibitors and histone deacetylase inhibitors are explored in initial chapters. These provide a detailed overview and important background to the entire field. The book is then focussed on epigenetic mechanisms involved in various diseases including anti-inflammatory and autoimmune conditions. Important accounts relating to the effects of epigenetics in metabolic syndrome, cardiovascular disease and asthma are the focus of subsequent chapters. The role of epigenetic dysregulation in malignancy is a current topic of interest and represents an intense field of research. A large component of this book is dedicated to the analysis of aberrant epigenetic processes in carcinogenesis and cancer progression. Further, chapters are focused on emerging cancer prevention using nutritional components and anti-cancer therapies particularly with histone deacetylase inhibitors, which have already been approved for the treatment of cutaneous T-cell lymphoma. The emerging role of nanoparticle preparations, especially in the context of delivering potential epigenetic therapies to target cells in various diseases, is also explored in this book. Overall, this book encompasses a wide range of topics related to epigenetic mechanisms in health and disease and would appeal to anyone with an interest in epigenetics, chromatin biology and emerging epigenetic interventions and therapies.