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Epigenetics Of Cancer Prevention

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Epigenetics of Cancer Prevention

Epigenetics of Cancer Prevention Book
Author : Anupam Bishayee,Deepak Bhatia
Publisher : Academic Press
Release : 2018-11-27
ISBN : 0128125667
Language : En, Es, Fr & De

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Book Description :

Epigenetics of Cancer Prevention, Volume Ten is the first to look at epigenetics and chemoprevention together. Although there is numerous scientific data available on how epigenetics can lead to cancer and how chemoprevention can be beneficial in the treatment of, or improvement of quality of life, together they will set an advanced understanding for the reader in this upcoming field of chemoprevention influencing epigenetics. This book discusses molecular epigenetic targets of natural products, such as green tea polyphenols, curcumin and resveratrol, and organ specific epigenetic targets related to diverse types of cancer, for example prostate, colorectal, breast, lung and skin cancers. Additionally, it encompasses a discussion on research methods and limitations to study epigenetics and epigenomics of chemopreventive drugs and personalized cancer treatment with phytochemicals. The book is ideal for cancer researchers, health care professionals and all individuals who are interested in cancer prevention research and its clinical applications, especially in natural remedies. Lists natural agents, including nutraceuticals, and their effects on normal or tumor genome Addresses various epigenetic systems and mechanisms in the regulation and support of the mammalian genome Discusses how various parts of dietary phytochemicals can influence or modify epigenetic mechanisms in several types of cancer

Emerging Epigenetics in Cancer Chemoprevention by Dietary Phytochemicals

Emerging Epigenetics in Cancer Chemoprevention by Dietary Phytochemicals Book
Author : Chengyue Zhang
Publisher : Unknown
Release : 2017
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Cancer chemoprevention is defined as the strategy to block or slow the onset of premalignant tumors and using relatively nontoxic chemical substance. Recently, accumulating experimental evidence has suggested that epigenetic alterations are involved in cancer development. The scope of epigenetics lies on the molecular interface between genetics and environmental factors; external factors switch genes on and off by influencing how cells read the genes. DNA methylation, histone covalent modification and remodeling, miRNA-mediated gene silencing represent the major mechanisms that play important role in epigenetic control of gene expression. This thesis focused on elucidating the epigenetic mechanisms in cancer prevention by dietary phytochemicals. Nrf2 is a master regulator of the antioxidant response and xenobiotic metabolism through the regulation of a wide range of antioxidant and phase II detoxification genes. The cellular protective role of Nrf2 points its potential as a primary target in chemoprevetion. Our group has reported that within tumor development in the transgenic adenocarcinoma of mouse prostate (TRAMP) model, there is a progressive loss of expression of Nrf2 and its downstream target genes, which is associated CpG hypermethylation in the promoter region. Using TRAMP C1 cells, we demonstrated that sulforaphane is a potent demethylation agent and it restores the epigenetically silenced Nrf2 gene through DNA demethylation. JB6 cells are derived from normal skin epidermis. We found that hypermethylation of Nrf2 promoter also exists in the transformation sensitive JB6 P+ cell line. The epigenetic reactivation of the Nrf2 signaling pathway by Tanshinone IIA could potentially contribute to the attenuation of JB6 P+ cellular transformation under the challenge of TPA, a tumor promoter. On the other hand, histone modification, in particular acetylation of H3K27 residue, is implicated in the transcription activation of pro-survival, pro-proliferative, and pro-inflammatory genes following TPA treatment. Bromodomain and extraterminal domain (BET) proteins function as epigenetic reader that recognizes acetylated histone tails and recruits the transcription machinery. Our study revealed that a small molecule BET inhibitor JQ-1 exerts potent anti-cancer and anti-inflammatory effects by interfering with the core transcriptional program of neoplastic transformation. Last but not least, altered levels of miRNA have been linked to tumor malignancy due to their ability to regulate functional gene expression in carcinogenesis. Using oligonucleotide microarray approach we identified the most affected miRNAs in LNCaP cells. Then we further assessed one potential target of PEITC - miR-194 in prostate cancer cell invasiveness. Collectively, dietary phytochemicals could modulate cellular epigenetic events that in part contribute to the cancer preventive effects. Given that oxidative stress and inflammation reaction are important (micro) environmental factors in malignancy transformation, understanding the role of redox and inflammatory signaling in epigenetic regulation could bring novel insights in cancer prevention.

Epigenetics in Cancer Prevention

Epigenetics in Cancer Prevention Book
Author : Mukesh Verma,Barbara K. Dunn,Asad Umar
Publisher : Unknown
Release : 2003
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

This volume addresses the question of how knowledge of epigenetic phenomena like DNA methylation and acetylation can be applied to early cancer detection and risk assessment. The objectives of the papers include defining the terminology used in epigenetics.

Cancer Epigenetics

Cancer Epigenetics Book
Author : Mukesh Verma
Publisher : Humana Press
Release : 2016-08-23
ISBN : 9781493948949
Language : En, Es, Fr & De

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Book Description :

This volume shares technologies that detect common epigenetic changes which are very important in the early detection, progression, and prognosis of cancer as well as the design of new therapeutic tools against cancer cells. Beginning with a bit of background on epigenetic mechanisms, Cancer Epigenetics: Risk Assessment, Diagnosis, Treatment, and Prognosis continues with cancer specific type epigenetic change, methods and technologies used for detecting epigenetic changes, factors that influence epigenetic changes in cancer, as well as a final section on future directions in the field. Written for the highly successful Methods in Molecular Biology series, chapters in this volume include the kind of detailed implementation advice that guarantees easily reproducible results. Comprehensive and practical, Cancer Epigenetics: Risk Assessment, Diagnosis, Treatment, and Prognosis provides the most up-to-date knowledge of epigenetics and its implication in cancer prevention by risk assessment and screening and cancer control by treatment.

Molecular mechanisms and physiology of disease

Molecular mechanisms and physiology of disease Book
Author : Nilanjana Maulik,Tom Karagiannis
Publisher : Springer
Release : 2014-05-31
ISBN : 1493907069
Language : En, Es, Fr & De

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Book Description :

In a simplified form, epigenetics refers to heritable changes in phenotype that are not due to changes in the underlying DNA sequence. In this book, epigenetic mechanisms of regulation and dysregulation in health and disease are explored in great depth. Detailed chapters on epigenetic processes including DNA methylation and chromatin post-translational modifications including potential interventions with DNA methyltransferase inhibitors and histone deacetylase inhibitors are explored in initial chapters. These provide a detailed overview and important background to the entire field. The book is then focussed on epigenetic mechanisms involved in various diseases including anti-inflammatory and autoimmune conditions. Important accounts relating to the effects of epigenetics in metabolic syndrome, cardiovascular disease and asthma are the focus of subsequent chapters. The role of epigenetic dysregulation in malignancy is a current topic of interest and represents an intense field of research. A large component of this book is dedicated to the analysis of aberrant epigenetic processes in carcinogenesis and cancer progression. Further, chapters are focused on emerging cancer prevention using nutritional components and anti-cancer therapies particularly with histone deacetylase inhibitors, which have already been approved for the treatment of cutaneous T-cell lymphoma. The emerging role of nanoparticle preparations, especially in the context of delivering potential epigenetic therapies to target cells in various diseases, is also explored in this book. Overall, this book encompasses a wide range of topics related to epigenetic mechanisms in health and disease and would appeal to anyone with an interest in epigenetics, chromatin biology and emerging epigenetic interventions and therapies.

Dietary Factors and Cancer Cell Epigenetics

Dietary Factors and Cancer Cell Epigenetics Book
Author : Colleen C. Spurling
Publisher : Unknown
Release : 2008
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Dietary Factors and Cancer Cell Epigenetics book written by Colleen C. Spurling, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Phytochemicals for Prostate Cancer Prevention

Phytochemicals for Prostate Cancer Prevention Book
Author : Ying Huang
Publisher : Unknown
Release : 2015
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Phytochemicals for Prostate Cancer Prevention book written by Ying Huang, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Epigenetics and Public Policy The Tangled Web of Science and Politics

Epigenetics and Public Policy  The Tangled Web of Science and Politics Book
Author : Shea K. Robison
Publisher : ABC-CLIO
Release : 2018-04-19
ISBN : 1440844704
Language : En, Es, Fr & De

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Book Description :

The exciting field of epigenetics offers novel and unanticipated science-based insights into human origins and development. This book presents one of the first detailed examinations of the political implications of epigenetics. • Focuses on the latest developments in epigenetics, a subject that is attracting increased attention among scientists and researchers yet is practically unknown among policymakers and members of the general public • Explains how epigenetics works, how it is related to genetics, how it differs from conventional genetics, the different kinds of epigenetic mechanisms, and the political history of genetics and epigenetics • Addresses the latest research on epigenetics within the context of hot public policy topics such as cancer, obesity, and the environment and identifies potential policy recommendations

Epigenetics in Cancer Prevention

Epigenetics in Cancer Prevention Book
Author : Mukesh Verma,Barbara K. Dunn,Asad Umar,National Cancer Institute (U.S.). Division of Cancer Prevention
Publisher : Unknown
Release : 2003-01-01
ISBN : 9781573314312
Language : En, Es, Fr & De

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Book Description :

Papers from a December 2001 conference review recent work in the field and determine future research needs in the area of epigenetics as it applies to early detection, risk assessment, and prevention of cancer. The basic mechanism of epigenetics-mediated regulation is explained, and technical approa

Epigenetics and Cancer

Epigenetics and Cancer Book
Author : Fazlul H. Sarkar
Publisher : Springer
Release : 2015-07-16
ISBN : 9789401780803
Language : En, Es, Fr & De

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Book Description :

Overall, this book illustrates the complexities of the regulation and deregulation of genes mediated through epigenetics in the development and progression of human malignancies. All the articles have been carefully chosen to represent several cancer systems with state of our knowledge on the role of epigenetic deregulation of microRNAs (miRNAs) and their target mRNAs along with epigenetic deregulation of mRNAs. This book also illustrates the role of several dietary agents, collectively called nutraceuticals or natural agents in modulating the epigenetic reprogramming of miRNAs and mRNAs for the prevention and/or treatment of human malignancies. It is well known that genetic aberrations, especially inherited through parents (somatic genetic alterations) contribute to the development of less than 10% of all cancer yet epigenetic alterations in genes especially through selective methylation and acetylation appears to be responsible for the development and progression of the vast majority of all cancers. Therefore, understanding the role of epigenetics in the regulation of genes especially through deregulated expression of miRNAs as presented in this book will allow scientists to devise targeted therapeutic strategies for re-expression of the lost genes or down-regulate the genes that are over-expressed in order to eradicate cancer. It is hoped that targeting epigenetics will not only target cancer cells but it will also target the tumor microenvironment (more like the entire tumor environment such as the entire host) for achieving better treatment outcomes for patients diagnosed with cancer which will lead to achieve the long-term objective for complete eradication of cancer. This book contains fifteen chapters which begins with the concept of systems and network biology for investigating the epigenetics of cancer followed by a series of articles on the role of miRNAs and their target genes in the biology of pancreatic cancer and other cancers such as breast, kidney, prostate and and colon. Since it is becoming increasingly clear that cancer stem cells (CSCs) are important in the development and progression of cancer, and CSCs are important in therapeutic resistance, treatment failure and tumor recurrence, thus the importance of CSCs and epigenetics has been highlighted by a very timely article on epigenetic variations of stem cell markers in cancer including miRNAs. Moreover, just targeting heterogeneous cancer cell populations may not be optimal to eradicate tumors and for which one must take a holistic approach for developing drugs that could also target the tumor microenvironment and tumor dormancy that are regulated through epigenetics. Keeping abreast with this thought process the concluding chapter provides a concept towards curative cancer therapy with maspin, which could be a unique window of opportunity to target tumor dormancy. Therefore, it suggest that targeting the tumor dormancy and the tumor microenvironment using novel therapeutics specifically by targeting epigenetics would become the future of medicine.

Epigenetics Territory and Cancer

Epigenetics Territory and Cancer Book
Author : Parvin Mehdipour
Publisher : Springer
Release : 2015-03-18
ISBN : 9401796394
Language : En, Es, Fr & De

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Book Description :

This book explores epigenetic strategies, bridging fundamental cancer epigenetics, different paradigms in tumor genetics and translational understanding for both the clinic and improved lifestyles. The work provides target-based insights for treating different types of cancers and presents research on evolutionary epigenetics, introducing ‘Medical Epi- Anthropology’ and ‘Cancer Epi-Anthropology’. Translating multi-disciplinary research into therapeutic design is at the core of this book. Readers may explore how cancer management involves unmasking the involved networks and the interactive status of different genes to achieve the appropriate methylome based therapy. Early chapters explore fundamental aspects and brain tumours, whilst later chapters investigate breast cancer and various other cancers, and the final chapter presents an evolutionary insight in cancer epigenetics, considering that the epigene is beyond DNA methylation, RNA interference and histone modification in cancer development. This book will be of interest to researchers in different medical and scientific fields, including clinical management (diagnosis, prognosis, prediction, prevention, and guidelines), genetic education, nutrition and nutrigenomics, industrial chemistry, and drug innovation. Because of the unique bridging between science and medicine this book will also be useful as an educational and translational research package.

Targeting Epigenetics and Nrf2 pathway by Dietary Phytochemicals

Targeting Epigenetics and Nrf2 pathway by Dietary Phytochemicals Book
Author : Yuqing Yang
Publisher : Unknown
Release : 2017
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

The induction of nuclear factor (erythroid-derived 2)-like 2 (Nrf2)- antioxidant response elements (ARE)-mediated antioxidant enzymes provides a cellular defense against oxidative stress, a major drive of human diseases such as the tumor. Phytochemicals in folk medicine are widely being used as natural sources to develop novel therapeutics. Astaxanthin (AST) with potent antioxidant activity in combination with omega-3 fatty acid docosahexaenoic acid (DHA) or eicosapentaenoic acid (EPA) at low concentration showed synergistic defense against oxidative stress via Nrf2-ARE pathway. The three natural chemicals alone and in combination elevated cellular GSH level, increased total antioxidant activity, induced mRNA expression of Nrf2 and its downstream genes in human HepG2-C8 cells. In addition, AST significantly decreased the methylation of GSTP1 promoter region and restored the expression of GSTP1, which is involved in detoxification and metabolism to prevent genome damage and cancer initiation. It suggests a correlation between the DNA methylation and GSTP1 expression in human prostate LNCaP cells. AST reduced protein expression and enzyme activity of the DNA methyltransferases (DNMTs). Moreover, we demonstrated that Nrf2 shows protective role in epidermis against inflammation and extracellular matrix (ECM) damage induced by the UVB-irradiation. As compared with the wildt-ype (WT) mice, Nrf2 knockout (KO) mice showed the increased protein expression of inflammatory markers, including P53, macrophage inflammatory protein-2 (MIP-2), and pro-matrix metalloproteinase-9 (pro-MMP-9). The protective effects of Nrf2 in response to the UVB-irradiation were mediated by increased HO-1 protein expression. Moreover, we conducted genome-wide analysis of DNA methylation in UVB- and DMBA-TPA induced mouse skin tumor models to identify genes and pathways with significant changes. The top-ranked genes and pathways will provide insight into the discovery of key genes in skin tumor initiation and progression so as to provide potential preventive biomarkers. Furthermore, we demonstrated that ursolic acid (UA), and sulforaphane (SFN) reduced in vivo skin carcinogenesis induced by UVB-irradiation. In conclusion, dietary natural chemicals alone or in combination attenuate oxidative stress, inflammation and even carcinogenesis through modulation of genetic and epigenetic events, and provide promising insights into cancer prevention.

Natural Products in Cancer Prevention and Therapy

Natural Products in Cancer Prevention and Therapy Book
Author : John M. Pezzuto,Nanjoo Suh
Publisher : Springer
Release : 2013-01-04
ISBN : 3642345751
Language : En, Es, Fr & De

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Book Description :

Chemoprevention of Esophageal Squamous Cell Carcinoma with Berries, by Gary D. Stoner and Li-Shu Wang Cancer Prevention by Different Forms of Tocopherols, by Chung S. Yang and Nanjoo Suh Cancer Chemopreventive and Therapeutic Potential of Guggulsterone, by Inas Almazari and Young-Joon Surh Inhibition of UVB-Induced Nonmelanoma Skin Cancer: A Path from Tea to Caffeine to Exercise to Decreased Tissue Fat, by Allan H. Conney, You-Rong Lou, Paul Nghiem, Jamie J. Bernard, George C. Wagner and Yao-Ping Lu Cancer Chemoprevention and Nutri-Epigenetics: State of the Art and Future Challenges, by Clarissa Gerhauser A Perspective on Dietary Phytochemicals and Cancer Chemoprevention: Oxidative Stress, Nrf2, and Epigenomics, by Zheng-Yuan Su, Limin Shu, Tin Oo Khor, Jong Hun Lee, Francisco Fuentes and Ah-Ng Tony Kong Keap1-Nrf2 Signaling: A Target for Cancer Prevention by Sulforaphane, by Thomas W. Kensler, Patricia A. Egner, Abena S. Agyeman, Kala Visvanathan, John D. Groopman, Jian-Guo Chen, Tao-Yang Chen, Jed W. Fahey and Paul Talalay Chemoprotection Against Cancer by Isothiocyanates: A Focus on the Animal Models and the Protective Mechanisms, by Albena T. Dinkova-Kostova Human Cancer Chemoprevention: Hurdles and Challenges, by Vaqar Mustafa Adhami and Hasan Mukhtar Personalizing Lung Cancer Prevention Through a Reverse Migration Strategy, by Kathryn A. Gold, Edward S. Kim, Ignacio I. Wistuba and Waun K. Hong Natural-Agent Mechanisms and Early-Phase Clinical Development, by Janet L. Wang, Kathryn A. Gold and Scott M. Lippman

Advances in Nutrition and Cancer

Advances in Nutrition and Cancer Book
Author : Vincenzo Zappia,Salvatore Panico,Gian Luigi Russo,Alfredo Budillon,Fulvio Della Ragione
Publisher : Springer Science & Business Media
Release : 2013-10-10
ISBN : 3642380077
Language : En, Es, Fr & De

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Book Description :

This book comprises proceedings from the Third International Conference on Advances in Nutrition and Cancer, held in Naples in May 2012. This highly multidisciplinary meeting analyzed “nutrition and cancer” from different perspectives and on the basis of distinct and up-to-date experimental approaches. Knowledge on the relation between lifestyle, diet, and cancer is explored in a number of contributions, and the role of dietary intervention in cancer patients is discussed. Issues of vital interest to the research community, such as epidemiological and experimental oncology (genetics, epigenetics, and the mechanisms of action of natural compounds in the diet), receive detailed consideration. A further key topic is the emerging molecular technologies (the “omics”) that can cast light on the interplay between nutrition and human malignancies. Chapters take the form of reviews that include sections presenting expert opinions.

Diet Epigenetic Events and Cancer Prevention

Diet  Epigenetic Events  and Cancer Prevention Book
Author : Sharon A. Ross,National Institutes of Health (Bethesda, Md.),Symposium Titled Diet, Epigenetic Events, and Cancer Prevention (2007, Bethesda, Md.)
Publisher : Unknown
Release : 2008
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Diet Epigenetic Events and Cancer Prevention book written by Sharon A. Ross,National Institutes of Health (Bethesda, Md.),Symposium Titled Diet, Epigenetic Events, and Cancer Prevention (2007, Bethesda, Md.), available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Cancer

Cancer Book
Author : Gary S. Stein,Kimberly P. Luebbers
Publisher : John Wiley & Sons
Release : 2019-10-01
ISBN : 1118962885
Language : En, Es, Fr & De

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Book Description :

A guide to recent insights into the genetic and epigenetic parameters of cancer biology and pathology and emerging clinical applications The thoroughly updated second edition of The Biology and Treatment of Cancer, now titled Cancer: Prevention, Early Detection, Treatment and Recovery, goes beyond reviewing the fundamental properties of cancer biology and the relevant issues associated with treatment of the disease. The new edition contains coverage of additional "patient centric" topics and presents cancer biology with selection of topics, facts, and perspectives written in easy-to-understand terms. With contributions from noted experts, the book explores recent advances in the understanding of cancer including breakthroughs in the molecular and cellular basis of cancer and provides strategies for approaching cancer prevention, early detection, and treatment. The authors incorporate recent information on the genetic and epigenetic parameters of cancer biology and pathology with indications of emerging clinical applications. The text offers a unique guide to cancer prevention, early detection, treatment, and recovery for students, caregivers, and most importantly cancer patients. This significant book: Incorporates current insight into the genetic and epigenetic parameters of cancer biology and pathology and information on emerging clinical applications Contains contributions from leaders in cancer research, care, and clinical trials Offers an accessible guide to an accurate and balanced understanding of cancer and the cancer patient Focuses on the importance of cancer prevention, early detection, treatment, and survivorship Written for medical students, students of cancer biology, and caregivers and cancer patients, Cancer: Prevention, Early Detection, Treatment and Recovery offers an authoritative overview of the challenges and opportunities associated with cancer biology, cancer research, and the spectrum of clinical considerations.

Selenium and Selenoproteins in Cancer

Selenium and Selenoproteins in Cancer Book
Author : Francesco Galli
Publisher : Academic Press
Release : 2017-10-19
ISBN : 0128120177
Language : En, Es, Fr & De

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Book Description :

Selenium and Selenoproteins in Cancer, Volume 136, the latest release in the Advances in Cancer Research series, provides invaluable information on the fast-moving field of cancer research. This updated volume includes chapters on The epidemiology of selenium and human cancer, Selenium, epigenetics and cancer, Selenium status and cancer risk, Nutritional aspects of selenium and breast cancer risk: focus on cellular and molecular mechanisms, Selenoproteins in tumorigenesis and cancer progression, Selenoproteins and metastasis, The tumor microenvironment and inflammatory factors, and Selenium-dependent glutathione peroxidases during tumor development. This new release in the series presents original reviews on research regarding the prevention and treatment of cancer with selenium. Provides information on cancer research and prevention Offers outstanding and original reviews on a range of cancer research topics, with this volume focusing on the role of selenium and selenoproteins in cancer prevention Serves as an indispensable reference for researchers and students alike

Cancer Epigenetics for Precision Medicine

Cancer Epigenetics for Precision Medicine Book
Author : Ramona G. Dumitrescu,Mukesh Verma
Publisher : Humana Press
Release : 2018-10-12
ISBN : 9781493987504
Language : En, Es, Fr & De

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Book Description :

This volume discusses certain epigenetic changes recognized in early carcinogenic lesions and different tumors, as well as factors that alter the epigenome and epigenetic profile such as diet, alcohol, immunity, circadian rhythm, and more. The chapters in this book further delve into this field and cover topics such as epigenome-based precision medicine in lung cancer; interplay between genetic and epigenetic changes in breast cancer subtypes; genetic regulation of PDCD1 gene in cancer immunology; and pyrosequencing methylation analysis. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and authoritative, Cancer Epigenetics for Precision Medicine: Methods and Protocols is a valuable resource to help researchers and scientists identify these specific biomarkers and work towards the prevention, diagnosis, and prognosis of different cancers in the future.

Beat Breast Cancer

Beat Breast Cancer Book
Author : Daniella Chace
Publisher : Skyhorse
Release : 2020-09-01
ISBN : 9781510755789
Language : En, Es, Fr & De

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Book Description :

A Cutting-Edge Guide to Preventing and Healing from Breast Cancer Beat Breast Cancer is a comprehensive and targeted program for using nutrition and detoxification to prevent and heal from breast cancer. Rooted in the science of epigenetics—how gene expression is affected by nutrients and toxins—Daniella Chace teaches readers to restore their own genes via diet, supplementation, and detoxification. Readers will learn how to: Nourish their bodies with more than one hundred foods that combat breast cancer. Chace also offers supplement recommendations for pre- and postmenopausal women. Restore their bodies by using new genetic tests to determine their personal nutrition and detox needs. Detoxify their bodies by flushing out the toxins that contribute to breast cancer development and disturb cellular communication. Carefully researched and incredibly comprehensive, Beat Breast Cancer forges a clear path toward health and healing.