Skip to main content

Epigenetics Of Aging And Longevity

In Order to Read Online or Download Epigenetics Of Aging And Longevity Full eBooks in PDF, EPUB, Tuebl and Mobi you need to create a Free account. Get any books you like and read everywhere you want. Fast Download Speed ~ Commercial & Ad Free. We cannot guarantee that every book is in the library!

Epigenetics of Aging and Longevity

Epigenetics of Aging and Longevity Book
Author : Alexey Moskalev,Alexander M. Vaiserman
Publisher : Academic Press
Release : 2017-11-17
ISBN : 012811083X
Language : En, Es, Fr & De

GET BOOK

Book Description :

Epigenetics of Aging and Longevity provides an in-depth analysis of the epigenetic nature of aging and the role of epigenetic factors in mediating the link between early-life experiences and life-course health and aging. Chapters from leading international contributors explore the effect of adverse conditions in early-life that may result in disrupted epigenetic pathways, as well as the potential to correct these disrupted pathways via targeted therapeutic interventions. Intergenerational epigenetic inheritance, epigenetic drug discovery, and the role of epigenetic mechanisms in regulating specific age-associated illnesses—including cancer and cardiovascular, metabolic, and neurodegenerative diseases—are explored in detail. This book will help researchers in genomic medicine, epigenetics, and biogerontology better understand the epigenetic determinants of aging and longevity, and ultimately aid in developing therapeutics to extend the human life-span and treat age-related disease. Offers a comprehensive overview of the epigenetic nature of aging, as well as the impact of epigenetic factors on longevity and regulating age-related disease Provides readers with clinical and epidemiological evidence for the role of epigenetic mechanisms in mediating the link between early-life experiences, life-course health and aging trajectory Applies current knowledge of epigenetic regulatory pathways towards developing therapeutic interventions for age-related diseases and extending the human lifespan

Epigenetics of Aging

Epigenetics of Aging Book
Author : Trygve O. Tollefsbol
Publisher : Springer Science & Business Media
Release : 2009-11-11
ISBN : 9781441906397
Language : En, Es, Fr & De

GET BOOK

Book Description :

Recent studies have indicated that epigenetic processes may play a major role in both cellular and organismal aging. These epigenetic processes include not only DNA methylation and histone modifications, but also extend to many other epigenetic mediators such as the polycomb group proteins, chromosomal position effects, and noncoding RNA. The topics of this book range from fundamental changes in DNA methylation in aging to the most recent research on intervention into epigenetic modifications to modulate the aging process. The major topics of epigenetics and aging covered in this book are: 1) DNA methylation and histone modifications in aging; 2) Other epigenetic processes and aging; 3) Impact of epigenetics on aging; 4) Epigenetics of age-related diseases; 5) Epigenetic interventions and aging: and 6) Future directions in epigenetic aging research. The most studied of epigenetic processes, DNA methylation, has been associated with cellular aging and aging of organisms for many years. It is now apparent that both global and gene-specific alterations occur not only in DNA methylation during aging, but also in several histone alterations. Many epigenetic alterations can have an impact on aging processes such as stem cell aging, control of telomerase, modifications of telomeres, and epigenetic drift can impact the aging process as evident in the recent studies of aging monozygotic twins. Numerous age-related diseases are affected by epigenetic mechanisms. For example, recent studies have shown that DNA methylation is altered in Alzheimer’s disease and autoimmunity. Other prevalent diseases that have been associated with age-related epigenetic changes include cancer and diabetes. Paternal age and epigenetic changes appear to have an effect on schizophrenia and epigenetic silencing has been associated with several of the progeroid syndromes of premature aging. Moreover, the impact of dietary or drug intervention into epigenetic processes as they affect normal aging or age-related diseases is becoming increasingly feasible.

Epigenetics of Aging

Epigenetics of Aging Book
Author : Trygve O. Tollefsbol
Publisher : Springer
Release : 2009-11-18
ISBN : 9781441906380
Language : En, Es, Fr & De

GET BOOK

Book Description :

Recent studies have indicated that epigenetic processes may play a major role in both cellular and organismal aging. These epigenetic processes include not only DNA methylation and histone modifications, but also extend to many other epigenetic mediators such as the polycomb group proteins, chromosomal position effects, and noncoding RNA. The topics of this book range from fundamental changes in DNA methylation in aging to the most recent research on intervention into epigenetic modifications to modulate the aging process. The major topics of epigenetics and aging covered in this book are: 1) DNA methylation and histone modifications in aging; 2) Other epigenetic processes and aging; 3) Impact of epigenetics on aging; 4) Epigenetics of age-related diseases; 5) Epigenetic interventions and aging: and 6) Future directions in epigenetic aging research. The most studied of epigenetic processes, DNA methylation, has been associated with cellular aging and aging of organisms for many years. It is now apparent that both global and gene-specific alterations occur not only in DNA methylation during aging, but also in several histone alterations. Many epigenetic alterations can have an impact on aging processes such as stem cell aging, control of telomerase, modifications of telomeres, and epigenetic drift can impact the aging process as evident in the recent studies of aging monozygotic twins. Numerous age-related diseases are affected by epigenetic mechanisms. For example, recent studies have shown that DNA methylation is altered in Alzheimer’s disease and autoimmunity. Other prevalent diseases that have been associated with age-related epigenetic changes include cancer and diabetes. Paternal age and epigenetic changes appear to have an effect on schizophrenia and epigenetic silencing has been associated with several of the progeroid syndromes of premature aging. Moreover, the impact of dietary or drug intervention into epigenetic processes as they affect normal aging or age-related diseases is becoming increasingly feasible.

Nutrition Exercise and Epigenetics Ageing Interventions

Nutrition  Exercise and Epigenetics  Ageing Interventions Book
Author : Byung Pal Yu
Publisher : Springer
Release : 2015-02-11
ISBN : 3319148303
Language : En, Es, Fr & De

GET BOOK

Book Description :

This book focuses on the three most important aspects of ageing research: nutrition, physical exercise and epigenetics. The contributors discuss ways that age-related epigenetic imprints such as DNA methylation and histone acetylation are modified by these two interventions. The emphasis on epigenetics helps to illuminate the underlying mechanisms of anti-ageing interventions, as ageing and disease are predominately epigenetic phenomena. Among the highlights are chapter-length discussion of such topics as: how anti-inflammatory action of calorie restriction underlies the retardation of ageing and age-related diseases (Chapter 3); epigenetic modification of gene expression by exercise (Chapter 5); the role of functional foods and their bioactive components in bone health (Chapter 8); and an account of the first decade of a study of calorie restriction in nonhuman primates, conducted by the National Institute on Ageing.

Longevity Genes

Longevity Genes Book
Author : Gil Atzmon, PhD
Publisher : Springer
Release : 2015-04-27
ISBN : 1493924044
Language : En, Es, Fr & De

GET BOOK

Book Description :

The release of the complete version of the human genome sequence in 2003 has paved the way for defining gene function and genetic background for phenotypic variation in humans and allowed us to study the aging process in a new light. This new volume results from that research and focuses on the genetic and epigenetic process of aging. While the interpretation of the genome data is still in its initial stages, this new volume looks at the evolving understanding of molecular mechanisms involved in cellular processes, gene function associated with complex traits, epigenetic components involve in gene control and the creation of hypothesis-free genome-wide approaches. Longevity Genes: A Blueprint for Aging explores the genetic and genomic elements that can maintain a long life such as DNA damage mechanisms, epigenetics and the way we can use this knowledge to generate customized treatments. It touches on some of the multidisciplinary approaches as well as genomic-wide association technology used to analyze complex traits. This book describes the hunt for genes affecting complex traits using a high throughput technology, with adequate consideration for the selection of an appropriate population, applications of statistical genetics and computational biology, and most importantly, considering phenotype-genotype association studies. Longevity Genes provides coverage of not only established aspects of genetics and aging, but also new approaches and perceptions in this important area of research.

Biomarkers of Human Aging

Biomarkers of Human Aging Book
Author : Alexey Moskalev
Publisher : Springer Nature
Release : 2019-09-13
ISBN : 3030249700
Language : En, Es, Fr & De

GET BOOK

Book Description :

This book collects and reviews, for the first time, a wide range of advances in the area of human aging biomarkers. This accumulated data allows researchers to assess the rate of aging processes in various organs and systems, and to individually monitor the effectiveness of therapies intended to slow aging. In an introductory chapter, the editor defines biomarkers of aging as molecular, cellular and physiological parameters that demonstrate reproducible changes - quantitative or qualitative - with age. The introduction recounts a study which aimed to create a universal model of biological age, whose most predictive parameters were albumin and alkaline phosphatase (indication liver function), glucose (metabolic syndrome), erythrocytes (respiratory function) and urea (renal function). The book goes on to describe DNA methylation, known as the “epigenetic clock,” as currently the most comprehensive predictor of total mortality. It is also useful for predicting mortality from cancer and cardiovascular diseases, and for analyzing the effects of lifestyle factors including diet, exercise, and education. Individual contributions draw additional insight from research on genetics and epigenetic aging markers, and immunosenescence and inflammaging markers. A concluding chapter outlines the challenge of integrating of biological and clinical markers of aging. Biomarkers of Human Aging is written for professionals and practitioners engaged in the study of aging, and will be useful to both advanced students and researchers.

Longevity Genes

Longevity Genes Book
Author : PhD Atzmon (Gil)
Publisher : Unknown
Release : 2015
ISBN : 9781493924059
Language : En, Es, Fr & De

GET BOOK

Book Description :

The release of the complete version of the human genome sequence in 2003 has paved the way for defining gene function and genetic background for phenotypic variation in humans and allowed us to study the aging process in a new light. This new volume results from that research and focuses on the genetic and epigenetic process of aging. While the interpretation of the genome data is still in its initial stages, this new volume looks at the evolving understanding of molecular mechanisms involved in cellular processes, gene function associated with complex traits, epigenetic components involve in gene control and the creation of hypothesis-free genome-wide approaches. Longevity Genes: A Blueprint for Aging explores the genetic and genomic elements that can maintain a long life such as DNA damage mechanisms, epigenetics and the way we can use this knowledge to generate customized treatments. It touches on some of the multidisciplinary approaches as well as genomic-wide association technology used to analyze complex traits. This book describes the hunt for genes affecting complex traits using a high throughput technology, with adequate consideration for the selection of an appropriate population, applications of statistical genetics and computational biology, and most importantly, considering phenotype-genotype association studies. Longevity Genes provides coverage of not only established aspects of genetics and aging, but also new approaches and perceptions in this important area of research.

Papers of the Conference on Genetics of Aging and Longevity 2012

Papers of the Conference on Genetics of Aging and Longevity 2012 Book
Author : Alexey Moskalev,Elena G. Pasyukova
Publisher : Frontiers E-books
Release : 2014-11-12
ISBN : 2889193535
Language : En, Es, Fr & De

GET BOOK

Book Description :

Download Papers of the Conference on Genetics of Aging and Longevity 2012 book written by Alexey Moskalev,Elena G. Pasyukova, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Life Extension

Life Extension Book
Author : Alexander M. Vaiserman,Alexey A. Moskalev,Elena G. Pasyukova
Publisher : Springer
Release : 2015-06-09
ISBN : 3319183265
Language : En, Es, Fr & De

GET BOOK

Book Description :

​This book looks at aging through research on Drosophila, the fruit fly that is one of the most widely used model organisms in bio gerontology. Work in model organisms can expand the theoretical knowledge of aging: it yields valuable insight into the molecular and cellular processes that underlie aging process, and it can perhaps provide new therapeutic targets for the treatment of age-related disorders in humans. Drosophila models have been developed for a large variety of aging-related processes and diseases, and this book provides readers with an overview of current research on the use of the Drosophila model to understand the genetic, molecular and physiological mechanisms that underlie the aging process. Themes of health span, life extension and longevity-associated genes emerge in this collation of international research on Drosophila that is of relevance to geriatrics and gerontology, animal genetics and genomics, and biomedicine. This fascinating, illustrated book will be of interest to a wide audience, ranging from academic researchers to the general reader.

Circadian Rhythms and Their Impact on Aging

Circadian Rhythms and Their Impact on Aging Book
Author : S. Michal Jazwinski,Victoria P Belancio,Steven M Hill
Publisher : Springer
Release : 2017-10-24
ISBN : 3319645439
Language : En, Es, Fr & De

GET BOOK

Book Description :

Biological rhythms time the ebb and flow of virtually every physiological process, and their mutual coordination guarantees the integrity of the organism over space and time. Aging leads to the disintegration of this coordination, as well as to changes in the amplitude and/or frequency of the underlying rhythms. The results of this are accelerated loss of health during aging, and in experimental model systems curtailed lifespan occurs. This book will examine the machinery that constitutes circadian systems and how they impact physiologic processes. It will also discuss how disturbances of circadian rhythms can lead to complex diseases associated with aging. Much of this treatment will focus on metabolism and genome stability. Importantly, the chapters in this book will encompass work in several different models, in addition to human. The book will conclude with a discussion of modeling approaches to biologic cycles and chronotherapy, for future research and translation.

Lifespan

Lifespan Book
Author : David A. Sinclair,Matthew D. LaPlante
Publisher : Atria Books
Release : 2019-09-10
ISBN : 1501191977
Language : En, Es, Fr & De

GET BOOK

Book Description :

A NEW YORK TIMES BESTSELLER “Brilliant and enthralling.”​ —The Wall Street Journal A paradigm-shifting book from an acclaimed Harvard Medical School scientist and one of Time’s most influential people. It’s a seemingly undeniable truth that aging is inevitable. But what if everything we’ve been taught to believe about aging is wrong? What if we could choose our lifespan? In this groundbreaking book, Dr. David Sinclair, leading world authority on genetics and longevity, reveals a bold new theory for why we age. As he writes: “Aging is a disease, and that disease is treatable.” This eye-opening and provocative work takes us to the frontlines of research that is pushing the boundaries on our perceived scientific limitations, revealing incredible breakthroughs—many from Dr. David Sinclair’s own lab at Harvard—that demonstrate how we can slow down, or even reverse, aging. The key is activating newly discovered vitality genes, the descendants of an ancient genetic survival circuit that is both the cause of aging and the key to reversing it. Recent experiments in genetic reprogramming suggest that in the near future we may not just be able to feel younger, but actually become younger. Through a page-turning narrative, Dr. Sinclair invites you into the process of scientific discovery and reveals the emerging technologies and simple lifestyle changes—such as intermittent fasting, cold exposure, exercising with the right intensity, and eating less meat—that have been shown to help us live younger and healthier for longer. At once a roadmap for taking charge of our own health destiny and a bold new vision for the future of humankind, Lifespan will forever change the way we think about why we age and what we can do about it.

Early Life Origins of Ageing and Longevity

Early Life Origins of Ageing and Longevity Book
Author : Alexander Vaiserman
Publisher : Springer
Release : 2019-07-29
ISBN : 3030249581
Language : En, Es, Fr & De

GET BOOK

Book Description :

This book provides a comprehensive overview of the field of developmental programming of ageing phenotypes. Although gerontological research has traditionally focused on later stages of the life cycle, growing evidence indicates that both the rate of ageing-associated functional declines, and the risks of later-life chronic pathological conditions, can be traced to origins early in life. While other books in the field concentrate on the developmental origin of particular disorders, this volume offers a detailed guide to all important aspects of the role of early-life conditions in programming both chronic pathological conditions and the ageing process. Interest in the study of ageing and longevity had its beginnings in research on the fetal origins of adult disease. This has evolved into a hypothesis on the Developmental Origins of Adult Health and Disease (DOHaD), which postulates that adverse environmental exposures during critical in-utero and early postnatal stages of development may permanently change physiological responses and cause functional impairments and disorders in adult life. In this book, the contributing authors and leading experts from around the world, describe research on mechanisms underlying the developmental programming phenomenon, as well as interventional strategies aimed at restoring developmentally disrupted epigenetic patterns. Early Life Origins of Ageing and Longevity benefits a wide audience of working scientists, clinicians, and advanced students, and will also interest scientifically curious general readers who wish to know more about current research in this rapidly evolving field.

Epigenetics in Human Disease

Epigenetics in Human Disease Book
Author : Trygve O. Tollefsbol
Publisher : Academic Press
Release : 2012
ISBN : 0123884152
Language : En, Es, Fr & De

GET BOOK

Book Description :

Epigenetics is one of the fastest growing fields of sciences, illuminating studies of human diseases by looking beyond genetic make-up and acknowledging that outside factors play a role in gene expression. The goal of this volume is to highlight those diseases or conditions for which we have advanced knowledge of epigenetic factors such as cancer, autoimmune disorders and aging as well as those that are yielding exciting breakthroughs in epigenetics such as diabetes, neurobiological disorders and cardiovascular disease. Where applicable, attempts are made to not only detail the role of epigenetics in the etiology, progression, diagnosis and prognosis of these diseases, but also novel epigenetic approaches to the treatment of these diseases. Chapters are also presented on human imprinting disorders, respiratory diseases, infectious diseases and gynecological and reproductive diseases. Since epigenetics plays a major role in the aging process, advances in the epigenetics of aging are highly relevant to many age-related human diseases. Therefore, this volume closes with chapters on aging epigenetics and breakthroughs that have been made to delay the aging process through epigenetic approaches. With its translational focus, this book will serve as valuable reference for both basic scientists and clinicians alike. Comprehensive coverage of fundamental and emergent science and clinical usage Side-by-side coverage of the basis of epigenetic diseases and their treatments Evaluation of recent epigenetic clinical breakthroughs

Epigenetic and PTEN Regulation of Longevity Pathways Related to Idiopathic Pulmonary Fibrosis and Organismal Aging

Epigenetic and PTEN Regulation of Longevity Pathways Related to Idiopathic Pulmonary Fibrosis and Organismal Aging Book
Author : Tierra A. Ware
Publisher : Unknown
Release : 2016
ISBN : 0987650XXX
Language : En, Es, Fr & De

GET BOOK

Book Description :

Understanding the cellular and molecular mechanisms that impact aging is important to improve accelerated aging diseases and promote healthy living in the aging population. Recent genetic studies provide clues on the mechanisms important in aging, specifically stem cell exhaustion, cellular senescence, telomere attrition and protein quality control mechanisms such as autophagy. Aging and some-age related diseases, such as pulmonary fibrosis are linked to these impaired mechanisms. The PTEN/PI3K/Akt/mTOR pathway is evolutionarily implicated and conserved in organismal longevity. In this pathway, PTEN promotes longevity by negatively regulating PI3K, Akt and mTOR activity. PTEN expression is down regulated in age-related diseases, such as cancer and idiopathic pulmonary fibrosis (IPF), resulting in activation of Akt and mTOR. These events promote cellular and organismal aging, which may drive pathogenic aging. In addition to PTEN as an important determinant of cellular longevity, telomerase activity and autophagy are also evolutionarily implicated and conserved in organismal aging. The overall objective of this proposal is to determine the impact of known aging pathways on organismal and lung aging in two parts. First, in Chapter 2, we elucidate how the loss of PTEN in mesenchymal stem cells (MSCs) impacts organismal aging. Second, we interrogate how the upregulation of DNA methyltransferases (DNMTs) target telomerase (Chapter 3) and autophagy genes (Chapter 4) in primary lung fibroblasts and lung tissues from IPF patients of different severity. We further demonstrate that DNMTs are upregulated via TGFß1in vitro (Chapter 5).

Longevity Promotion Multidisciplinary Perspectives

Longevity Promotion  Multidisciplinary Perspectives Book
Author : Ilia Stambler PhD
Publisher : Lulu Press, Inc
Release : 2017-08-14
ISBN : 1387164058
Language : En, Es, Fr & De

GET BOOK

Book Description :

This book considers the multidisciplinary aspects of longevity promotion, from the advocacy, historical, philosophical and scientific perspectives. The first part on longevity advocacy includes examples of pro-longevity campaigns, outreach materials, frequent debates and policy suggestions. The second part on longevity history includes historical analyses of life-extensionism as a social and intellectual movement. The third part on longevity philosophy surveys the aspirations and arguments for increasing healthy longevity in the philosophical and religious traditions of ancient Greece, India, the Middle East, in particular in Islam and Judaism, and the Christian tradition. Finally, the fourth part on longevity science includes brief discussions of some of the scientific issues in life extension research. These discussions are in no way exhaustive, but are intended to simulate additional interest, consultation and study of longevity science and its social and cultural implications.

The Abolition of Aging

The Abolition of Aging Book
Author : David W Wood
Publisher : Delta Wisdom
Release : 2016-06-06
ISBN : 9780995494206
Language : En, Es, Fr & De

GET BOOK

Book Description :

Within our collective grasp dwells the remarkable possibility of the abolition of biological aging. It's a big "if," but if we decide as a species to make this project a priority, there's around a 50% chance that practical rejuvenation therapies resulting in the comprehensive reversal of aging will be widely available as early as 2040. People everywhere, on the application of these treatments, will, if they wish, stop becoming biologically older. Instead, again if they wish, they'll start to become biologically younger, in both body and mind, as rejuvenation therapies take hold. In short, everyone will have the option to become ageless. The viewpoint just described is a position the author has reached following extensive research, carried out over more than ten years. His research has led him to become a strong supporter of what can be called "the rejuveneering project" a multi-decade cross-disciplinary endeavour to engineer human rejuvenation and thereby enable the choice to abolish aging. But this viewpoint frequently encounters one of two adverse reactions. First, people say that it's not possible that such treatments are going to exist in any meaningful timescale any time soon. In other words, they insist that human rejuvenation can't be done. It's wishful thinking to suppose otherwise, they say. It's bad science. It's naively over-optimistic. It's ignorant of the long history of failures in this field. The technical challenges remain overwhelmingly difficult. Second, people say that any such treatments would be socially destructive and morally indefensible. In other words, they insist that human rejuvenation shouldn't be done. It's essentially a selfish idea, they say - an idea with all kinds of undesirable consequences for societal harmony or planetary well-being. It's an arrogant idea, from immature minds. It's an idea that deserves to be strangled. Can't; shouldn't - this books argues that both these objections are profoundly wrong. It argues instead that rejuvenation is a noble, highly desirable, eminently practical destiny for our species - a "Humanity+" destiny that could be achieved within just one human generation from now. In the author's view, the abolition of aging is set to take its place on the upward arc of human social progress, echoing developments such as the abolition of slavery, the abolition of racism, and the abolition of poverty. This is a discussion with enormous consequences. Changes in the public mood regarding the desirability of rejuveneering could trigger large reallocations of both public and private research expenditure. In turn, these reallocations are likely to have major implications in many areas of public well-being. Clearly, these decisions need to be taken wisely - with decisions being guided by a better understanding of the rich landscape of rejuveneering possibilities. Due to complexities and unknowns, no one can be sure of the outcome of this project. Despite what some rejuvenation enthusiasts may suggest, there's nothing inevitable about the pace of future medical progress. That's why the author gives the probability of success as only around 50%. Although the end outcome remains unclear, the sense of discovery is increasing. The underlying scientific context is changing rapidly. Every day brings its own fresh firehose of news of potential breakthrough medical approaches. In the midst of so much innovation, it behoves us to seek clarity on the bigger picture. To the extent that this book can provide that bigger picture, it will have met at least some of its goals. Armed with that bigger picture, readers of this book will, hopefully, be better placed to find the aspect of the overall rejuveneering project where they can make their best contributions. Together, we can tilt that 50% success probability upwards. The sooner, the better. Note: For advance feedback on this book, see https: //theabolitionofaging.com/.

Ageing and Senescence

Ageing and Senescence Book
Author : Muralidhar S. Talkad,Akanksha Rai,Sneha Srivathasava
Publisher : LAP Lambert Academic Publishing
Release : 2014-02-24
ISBN : 9783659494840
Language : En, Es, Fr & De

GET BOOK

Book Description :

Molecular genetics - with biotechnological tools, metabolic engineering, and disease diagnosis with pathophysiology in which there is a considerable enthusiasm driving new discoveries. Epigenomes would serve as a reference for comparison with diseased tissues, revealing epigenetic causes of disease. The importance of epigenetics in human disease, together with the maturing of technologies for mapping epigenetic changes, makes a human epigenome project both critical and feasible. On recurrent epigenetic modification like DNA methylation, normal, disease implications, and the current scenario as to how it is dealt with. There are many findings or research done on these epigenetic behavior that suggest modern approaches are being implemented so as to provide new platform for understanding Ageing process, genes, diet, habitat, environmental interactions can further better understanding and discovering genes that regulate longevity by identifying single gene mutations that lead to increased longevity. SIRT1 is a NAD+-dependent protein deacetylase, that governs many physiological pathways, SIRT1 may play an important role in aging.

Handbook of the Biology of Aging

Handbook of the Biology of Aging Book
Author : Matt Kaeberlein,George Martin
Publisher : Academic Press
Release : 2015-09-08
ISBN : 9780124115965
Language : En, Es, Fr & De

GET BOOK

Book Description :

Handbook of the Biology of Aging, Eighth Edition, provides readers with an update on the rapid progress in the research of aging. It is a comprehensive synthesis and review of the latest and most important advances and themes in modern biogerontology, and focuses on the trend of 'big data' approaches in the biological sciences, presenting new strategies to analyze, interpret, and understand the enormous amounts of information being generated through DNA sequencing, transcriptomic, proteomic, and the metabolomics methodologies applied to aging related problems. The book includes discussions on longevity pathways and interventions that modulate aging, innovative new tools that facilitate systems-level approaches to aging research, the mTOR pathway and its importance in age-related phenotypes, new strategies to pharmacologically modulate the mTOR pathway to delay aging, the importance of sirtuins and the hypoxic response in aging, and how various pathways interact within the context of aging as a complex genetic trait, amongst others. Covers the key areas in biological gerontology research in one volume, with an 80% update from the previous edition Edited by Matt Kaeberlein and George Martin, highly respected voices and researchers within the biology of aging discipline Assists basic researchers in keeping abreast of research and clinical findings outside their subdiscipline Presents information that will help medical, behavioral, and social gerontologists in understanding what basic scientists and clinicians are discovering New chapters on genetics, evolutionary biology, bone aging, and epigenetic control Provides a close examination of the diverse research being conducted today in the study of the biology of aging, detailing recent breakthroughs and potential new directions

Adipose Tissue Which Role in Aging and Longevity

Adipose Tissue  Which Role in Aging and Longevity  Book
Author : Antonello Lorenzini,Aurelia Santoro,Daniela Monti
Publisher : Frontiers Media SA
Release : 2020-09-18
ISBN : 288966032X
Language : En, Es, Fr & De

GET BOOK

Book Description :

Download Adipose Tissue Which Role in Aging and Longevity book written by Antonello Lorenzini,Aurelia Santoro,Daniela Monti, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Lifespan

Lifespan Book
Author : David A. Sinclair,Matthew D. LaPlante
Publisher : Unknown
Release : 2019
ISBN : 9780008380328
Language : En, Es, Fr & De

GET BOOK

Book Description :

From an acclaimed Harvard professor and one of Time's most influential people, this paradigm-shifting book shows how almost everything we think we know about aging is wrong, offers a front-row seat to the amazing global effort to slow, stop, and reverse aging, and calls readers to consider a future where aging can be treated. For decades, experts have believed that we are at the mercy of our genes, and that natural damage to our genes--the kind that inevitably happens as we get older--makes us become sick and grow old. But what if everything you think you know about aging is wrong? What if aging is a disease--and that disease is treatable? In Lifespan, one of the world's foremost experts on aging and genetics reveals a groundbreaking new theory that will forever change the way we think about why we age and what we can do about it. Aging isn't immutable; we can have far more control over it than we realize. This eye-opening and provocative work takes us to the frontlines of research that is pushing the boundaries on our perceived scientific limitations, revealing incredible breakthroughs--many from Dr. David Sinclair's own lab--that demonstrate how we can slow down, or even reverse, the genetic clock. The key is activating newly discovered vitality genes--the decedents of an ancient survival circuit that is both the cause of aging and the key to reversing it. Dr. Sinclair shares the emerging technologies and simple lifestyle changes--such as intermittent fasting, cold exposure, and exercising with the right intensity--that have been shown to help lead to longer lives. Lifespan provides a roadmap for taking charge of our own health destiny and a bold new vision for the future when humankind is able to live to be 100 years young.