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Epigenetics In Psychiatry

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Epigenetics in Psychiatry

Epigenetics in Psychiatry Book
Author : Jacob Peedicayil,Dennis R. Grayson,Dimitri Avramopoulos
Publisher : Elsevier
Release : 2014-06-23
ISBN : 0124171346
Language : En, Es, Fr & De

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Book Description :

Epigenetics in Psychiatry covers all major areas of psychiatry in which extensive epigenetic research has been performed, fully encompassing a diverse and maturing field, including drug addiction, bipolar disorder, epidemiology, cognitive disorders, and the uses of putative epigenetic-based psychotropic drugs. Uniquely, each chapter correlates epigenetics with relevant advances across genomics, transcriptomics, and proteomics. The book acts as a catalyst for further research in this potentially very important and useful area of psychiatry. The elucidation of basic principles of epigenetic biology points to the creation of more optimal and effective therapies for major classes of psychiatric disease. In this regard, epigenetic therapy, the use of drugs to correct epigenetic defects, may help in the pharmacotherapy of patients with these disorders. With time, such advances may eventually point to replacements for psychotropic drugs presently of symptomatic value and low efficacy. Moreover, there is evidence to suggest that other forms of treatment commonly used in the management of psychiatric disorders, like psychotherapy and electroconvulsive therapy, may also act by epigenetic mechanisms. Chapters review fascinating new areas of research across neuronal stem cells, cognitive disorders, and transgenerational epigenetics through drug addiction Relates broad advances in psychiatric epigenetics to a modern understanding of the genome, transcriptome, and protein Catalyzes knowledge discovery in both basic epigenetic biology and clinical application as epigenetic targets for drug discovery

Genetics and Epigenetics of Psychiatric Diseases

Genetics and Epigenetics of Psychiatric Diseases Book
Author : Cunyou Zhao,Weihua Yue,Zhexing Wen
Publisher : Frontiers Media SA
Release : 2020-07-10
ISBN : 2889633950
Language : En, Es, Fr & De

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Book Description :

Psychiatric diseases have a highly complex etiology, aggregating in families but not segregating in a traditional Mendelian manner. Recent approaches to understanding the causes of psychiatric disease have focused on describing the genetic contribution to major psychiatric illnesses; the use of large-scale genome-wide association studies (GWAS) and exome sequencing has enabled a systematic exploration of genetic risk factors and identified over 100 independent genomic loci significantly associated with psychiatric diseases; however, there remains uncertainty about the causal genes involved in disease pathogenesis, and how their function is regulated. Since many GWAS variants reside in non-coding regions, the disease-associated common variants might be enriched in regulatory domains, including enhancers and regions of active chromatin state. These lead us to focus on the possible role of non-sequence-based genomic variation in health and disease. Of particular interest are epigenetic modifications that regulate gene expression through modifications to DNA, RNA, histone proteins, and chromatin. The availability of high-throughput profiling methods for quantifiying epigenomic modifications in large numbers of samples has enabled us to perform epigenome-wide association studies (EWAS) aimed at screening methylomic variations associated with environmental exposure and disease. Thus systematic integration of genetic, epigenetic and epidemiological approaches will contribute to improving our understanding of the molecular mechanisms underlying disease phenotypes.

Epigenetics and Neuroendocrinology

Epigenetics and Neuroendocrinology Book
Author : Dietmar Spengler,Elisabeth Binder
Publisher : Springer
Release : 2016-04-02
ISBN : 3319244930
Language : En, Es, Fr & De

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Book Description :

The field of neuroendocrinology has extended from the initial interest in the hypothalamic control of pituitary secretion to embrace multiple reciprocal interactions between the central nervous system and endocrine systems in the coordination of homeostasis and various physiological responses from adaptation to disease. Most recently, epigenetic mechanisms were recognized for their role in the development of the neuroendocrine axes as well as in the mediation of gene-environment interactions in stress-related psychiatry disorders.

Epigenetics in Psychiatry Characterization of the Immune System and Its Methylome in Depressed Patients Receiving Electroconvulsive Therapy

Epigenetics in Psychiatry   Characterization of the Immune System and Its Methylome in Depressed Patients Receiving Electroconvulsive Therapy Book
Author : Nicole Katherin Moschny
Publisher : Unknown
Release : 2020
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Epigenetics in Psychiatry Characterization of the Immune System and Its Methylome in Depressed Patients Receiving Electroconvulsive Therapy book written by Nicole Katherin Moschny, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Neuropsychiatric Disorders and Epigenetics

Neuropsychiatric Disorders and Epigenetics Book
Author : Dag Yasui,Jacob Peedicayil,Dennis R. Grayson
Publisher : Academic Press
Release : 2016-11-15
ISBN : 0128005270
Language : En, Es, Fr & De

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Book Description :

Neuropsychiatric Disorders and Epigenetics is a comprehensive reference for the epigenetic basis of most common neuropsychiatric disorders. The volume is organized into chapters representing individual neuropsychiatric disorders, from addition to obesity contributed by leading experts in their respective fields. The epigenetic aspects of each disorder are discussed, in the context of the full range of epigenetic mechanisms including DNA modification, histone post-translational modification, chromatin organization and non-coding RNA. A particular emphasis is placed on potential epigenetic interventions, when the effects of environmental stimuli on epigenetic states is particularly relevant o disease. Recent discoveries in epigenetic research enabled by epic advances in genomic technologies have positioned the field for broad translation to therapeutic interventions for previously unmanageable disorders Neuropsychiatric disorders represent a prime target of epigenetic interventions as they are highly debilitating, often chronic diseases with enormous costs to society. Thus, this volume will help define epigenetics as a key player in neuropsychiatric disorders, highlighting the full spectrum of epigenetic mechanisms underlying such disorders and introducing the vast range of epigenetic therapies under development. Analyzes the effects of environmental stimuli on epigenetic states that correlate with neuropsychiatric disease induction Reviews the epigenetic basis for common neuropsychiatric disorders, thereby guiding translational therapies for clinicians and mechanistic studies for scientists Extensive use of diagrams, illustrations, tables, and graphical abstracts for each section providing rapid assessment

Psychiatry Reborn Biopsychosocial Psychiatry in Modern Medicine

Psychiatry Reborn  Biopsychosocial Psychiatry in Modern Medicine Book
Author : Lecturer in Philosophy Will Davies,Will Davies,Uehiro Chair in Practical Ethics Professor Julian Savalescu,Professor Julian Savalescu,Rebecca Roache,Senior Lecturer in Philosophy Rebecca Roache,Professor J. Pierre Loebel
Publisher : Oxford University Press, USA
Release : 2020-06-15
ISBN : 0198789696
Language : En, Es, Fr & De

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Book Description :

With contributions from psychiatry, psychology, neuroscience, and philosophy, this book provides the most comprehensive account to date of the interplay between biological, psychological, and social factors in mental health and their ethical dimensions.

Computational Psychiatry

Computational Psychiatry Book
Author : Rodrick Wallace
Publisher : Springer
Release : 2017-04-20
ISBN : 3319539108
Language : En, Es, Fr & De

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Book Description :

This book explores mental disorders from a uniquely evolutionary perspective. Although there have been many attempts to mathematically model neural processes and, to some extent, their dysfunction, there is very little literature that models mental function within a sociocultural, socioeconomic, and environmental context. Addressing this gap in the extant literature, this book explores essential aspects of mental disorders, recognizing the ubiquitous role played by the exaptation of crosstalk between cognitive modules at many different scales and levels of organization, the missing heritability of complex diseases, and cultural epigenetics. Further, it introduces readers to valuable control theory tools that permit the exploration of the environmental induction of neurodevelopmental disorders, as well as the study of the synergism between culture, psychopathology and sleep disorders, offering a distinctively unique resource.

Psychiatric Genetics

Psychiatric Genetics Book
Author : Thomas Schulze,Francis McMahon
Publisher : Oxford University Press
Release : 2018
ISBN : 0190221976
Language : En, Es, Fr & De

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Book Description :

Psychiatrists and other mental health professionals are increasingly confronted with questions about the genetics of psychiatric illness, and the clinical applications of new genetic findings. Psychiatric Genetics: A Primer for Clinical and Basic Scientists addresses these questions through a straightforward introduction to the essentials of psychiatric genetics, complementing more comprehensive textbooks that may seem overwhelming for those new to the field. Written and edited by leaders in the field and the International Society of Psychiatric Genetics (ISPG), the book covers basic epidemiology, recruitment for human studies, phenotyping strategies, formal genetic and molecular genetic studies, statistical genetics, bioinformatics and genomics, pharmacogenetics, the most relevant animal models, and biobanking. Each chapter begins with a list of "take home" points that summarizes content, followed by a brief overview of current knowledge and suggestions for further reading. This Primer is ideal for medical students, psychiatric residents, psychiatrists, and basic neuroscience researchers who are interested in learning about the key concepts and recent advances in the exciting field of psychiatric genetics.

New Oxford Textbook of Psychiatry

New Oxford Textbook of Psychiatry Book
Author : John R. Geddes,Nancy C. Andreasen
Publisher : Oxford University Press, USA
Release : 2020-02-20
ISBN : 0198713002
Language : En, Es, Fr & De

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Book Description :

Over its two editions, The New Oxford Textbook of Psychiatry has come to be regarded as one of the most popular and trusted standard psychiatry texts among psychiatrists and trainees. Bringing together 146 chapters from the leading figures in the discipline, it presents a comprehensive account of clinical psychiatry, with reference to its scientific basis and to the patient's perspective throughout. The New Oxford Textbook of Psychiatry, Third Edition has been extensively re-structured and streamlined to keep pace with the significant developments that have taken place in the fields of clinical psychiatry and neuroscience since publication of the second edition in 2009. The new edition has been updated throughout to include the most recent versions of the two main classification systems---the DSM-5 and the ICD-11---used throughout the world for the diagnosis of mental disorders. In the years since publication of the first edition, many new and exciting discoveries have occurred in the biological sciences, which are having a major impact on how we study and practise psychiatry. In addition, psychiatry has fostered closer ties with philosophy, and these are leading to healthy discussions about how we should diagnose and treat mental illness. This new edition recognises these and other developments. Throughout, accounts of clinical practice are linked to the underlying science, and to the evidence for the efficacy of treatments. Physical and psychological treatments, including psychodynamic approaches, are covered in depth. The history of psychiatry, ethics, public health aspects, and public attitudes to psychiatry and to patients are all given due attention.

Overlapping Pain and Psychiatric Syndromes

Overlapping Pain and Psychiatric Syndromes Book
Author : Mario Incayawar,Sioui Maldonado Bouchard,Michael R. Clark
Publisher : Oxford University Press, USA
Release : 2020-09-09
ISBN : 0190248254
Language : En, Es, Fr & De

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Book Description :

This book describes the complex and striking relationships between pain and psychiatric disorders, offering an in-depth review of the challenging and neglected intersection between pain medicine and psychiatry.

Epigenetics and Neuroplasticity Evidence and Debate

Epigenetics and Neuroplasticity   Evidence and Debate Book
Author : Anonim
Publisher : Academic Press
Release : 2014-11-05
ISBN : 0128010851
Language : En, Es, Fr & De

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Book Description :

The ‘epi-(Greek for ‘over’, ‘above’)genome’, with its rich cache of highly regulated, structural modifications—including DNA methylation, histone modifications and histone variants—defines the moldings and three-dimensional structures of the genomic material inside the cell nucleus and serves, literally, as a molecular bridge linking the environment to the genetic materials in our brain cells. Due to technological and scientific advances in the field, the field of neuroepigenetics is currently one of the hottest topics in the basic and clinical neurosciences. The volume captures some of this vibrant and exciting new research, and conveys to the reader an up-to-date discussion on the role of epigenetics across the lifespan of the human brain in health and disease. Topics cover the entire lifespan of the brain, from transgenerational epigenetics to neurodevelopmental disease to disorders of the aging brain. All chapters are written with dual intent, to provide the reader with a timely update on the field, and a discussion of provocative or controversial findings in the field with the potential of great impact for future developments in the field.

Schizophrenia Bulletin

Schizophrenia Bulletin Book
Author : Anonim
Publisher : Unknown
Release : 1999
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Schizophrenia Bulletin book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Epigenetic Aspects of Chronic Diseases

Epigenetic Aspects of Chronic Diseases Book
Author : Helmtrud I. Roach,Felix Bronner,Richard O.C. Oreffo
Publisher : Springer Science & Business Media
Release : 2011-04-01
ISBN : 9781848826441
Language : En, Es, Fr & De

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Book Description :

Epigenetic Aspects of Chronic Diseases assembles in comprehensive form what is known about the role of epigenetics in chronic disease development. This book provides new insights into treatment, including modulation of epigenetic regulation. Each chapter gives an outline of a respective disease, explains why epigenetics may be involved in the disease process and then presents the evidence of how changes in epigenetic status contribute to initiation and progress of the disease. The final chapters look towards future therapeutic treatment, based on manipulation of epigenetic aspects. Written by widely published experts, Epigenetic Aspects of Chronic Diseases is a valuable reference tool for clinicians and researchers who investigate and treat chronic diseases, as well as health care personnel, post-doctoral fellows and medical or dental students.

Epigenetic Epidemiology

Epigenetic Epidemiology Book
Author : Karin B. Michels
Publisher : Springer Science & Business Media
Release : 2012-01-03
ISBN : 9400724942
Language : En, Es, Fr & De

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Book Description :

The exploding field of epigenetics is challenging the dogma of traditional Mendelian inheritance. Epigenetics plays an important role in shaping who we are and contributes to our prospects of health and disease. While early epigenetic research focused on plant and animal models and in vitro experiments, population-based epidemiologic studies increasingly incorporate epigenetic components. The relevance of epigenetic marks, such as DNA methylation, genomic imprinting, and histone modification for disease causation has yet to be fully explored. This book covers the basic concepts of epigenetic epidemiology, discusses challenges in study design, analysis, and interpretation, epigenetic laboratory techniques, the influence of of age and environmental factors on shaping the epigenome, the role of epigenetics in the developmental origins hypothesis, and provides the state of the art on the epigenetic epidemiology of various health conditions including childhood syndromes, cancer, infectious diseases, inflammation and rheumatoid arthritis, asthma, autism and other neurodevelopmental disorders, psychiatric disorders, diabetes, obesity and metabolic disorders, and atherosclerosis. With contributions from: Peter Jones, Jean-Pierre Issa, Gavin Kelsey, Robert Waterland, and many other experts in epigenetics!

Epigenetic Regulation in the Nervous System

Epigenetic Regulation in the Nervous System Book
Author : J. David Sweatt,Michael J. Meaney,Eric J. Nestler,Schahram Akbarian
Publisher : Academic Press
Release : 2012-12-31
ISBN : 0123944058
Language : En, Es, Fr & De

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Book Description :

Epigenetic Regulation in the Nervous System addresses current understanding of the roles of epigenetic processes at the molecular/cellular level, their impact on neural development and behavior, and the potential roles of these mechanisms in neurological and psychiatric disorders. This award-winning volume spans molecular epigenetics, development, cellular physiology and biochemistry, synaptic and neural plasticity, and behavioral models, and is unique in covering epigenetically based disorders of the central nervous system. Behavioral epigenetics is the study of how environmental factors alter behavior, addressing the fundamental mechanisms that shape development and individual vulnerability/resilience to adverse behavioral outcomes. By understanding the molecular mechanisms involved in epigenetic modulation, researchers may be able to develop targeted therapies for those individuals in whom it malfunctions. Edited by the most highly regarded leaders in the field, this book offers a comprehensive review of behavioral epigenetics and a balanced treatment of the strengths and weaknesses in experimentation in this area. Covering background material as well as topics of current interest, it serves both as a cutting-edge resource and a foundational reference. The book will benefit neuroscience researchers and graduate students with an interest in the links between gene regulation and behavior, as will clinicians dealing with disorders such as addiction, depression, and schizophrenia. BMA Medical Book Awards 2014 - Highly Commended, Neurology, British Medical Association BMA Medical Book Awards 2014 - First Prize, Neurology, British Medical Association 2013 PROSE Award winner for Best in Reference Works and Best Single Volume Reference in Science from the Association of American Publishers Presents a unified view of epigenetic mechanisms from behavior to genes and everything in between Discusses clinically relevant disorders in the context of epigenetics research, making the volume appealing to clinicians as well as basic scientists Provides numerous practical examples for the new investigator to facilitate implementation of research in neuroepigenetics

Stress Genetics Epigenetics and Genomics

Stress  Genetics  Epigenetics and Genomics Book
Author : George Fink
Publisher : Academic Press
Release : 2020-10-24
ISBN : 0128131578
Language : En, Es, Fr & De

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Book Description :

This fourth volume in the Handbook of Stress series, Stress: Genetics, Epigenetics and Genomics, deals with the influence that genetics, epigenetics, and genomics have on the effects of and responses to stress. Chapters refer to epigenetic mechanisms that involve DNA methylation, histone modification, and/or noncoding RNA-associated gene activation or silencing. There is also coverage of epigenetic mechanisms in stress-related transgenerational transmission of characteristics, and how these may help explain heritability in some complex human diseases. The Handbook of Stress series, comprised of self-contained volumes that each focus on a specific stress area, covers the significant advances made since the publication of Elsevier’s Encyclopedia of Stress (2000 and 2007). Volume 4 is ideal for graduate students, post-doctoral fellows, faculty and clinicians interested in stress genetics, epigenetics and genomics involved in neuroendocrinology, neuroscience, biomedicine, endocrinology, psychology, psychiatry and the social sciences. Articles carefully selected by eminent stress researchers and prepared by contributors representing outstanding scholarship in the field, with each chapter fully vetted for reliable expert knowledge Richly illustrated with explanatory figures and tables Each chapter includes a boxed “Key points call out section Affordably priced, self-contained volume for readers specifically interested in stress genetics and epigenetics, removing the need to purchase the whole Handbook series

Indian Journal of Medical Research

Indian Journal of Medical Research Book
Author : Anonim
Publisher : Unknown
Release : 2007
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Indian Journal of Medical Research book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

An Epigenetic Basis for an Omnigenic Model of Psychiatric Disorders

An Epigenetic Basis for an Omnigenic Model of Psychiatric Disorders Book
Author : Anonim
Publisher : Unknown
Release : 2018
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Highlights: Recently, the omnigenic model for the inheritance of complex traits was proposed. There is increasing evidence that there are abnormalities of epigenetic mechanisms of gene expression underlying psychiatric disorders. This article invokes abnormalities of epigenetic mechanisms of gene expression to propose an omnigenic model for the inheritance of schizophrenia, bipolar disorder, and major depressive disorder.

Principles of Psychiatric Genetics

Principles of Psychiatric Genetics Book
Author : John I. Nurnberger, Jr,Wade Berrettini
Publisher : Cambridge University Press
Release : 2012-09-13
ISBN : 1139560379
Language : En, Es, Fr & De

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Book Description :

Disorders of behavior represent some of the most common and disabling diseases affecting humankind; however, despite their worldwide distribution, genetic influences on these illnesses are often overlooked by families and mental health professionals. Psychiatric genetics is a rapidly advancing field, elucidating the varied roles of specific genes and their interactions in brain development and dysregulation. Principles of Psychiatric Genetics includes 22 disorder-based chapters covering, amongst other conditions, schizophrenia, mood disorders, anxiety disorders, Alzheimer's disease, learning and developmental disorders, eating disorders and personality disorders. Supporting chapters focus on issues of genetic epidemiology, molecular and statistical methods, pharmacogenetics, epigenetics, gene expression studies, online genetic databases and ethical issues. Written by an international team of contributors, and fully updated with the latest results from genome-wide association studies, this comprehensive text is an indispensable reference for psychiatrists, neurologists, psychologists and anyone involved in psychiatric genetic studies.

The Oxford Handbook of Molecular Psychology

The Oxford Handbook of Molecular Psychology Book
Author : Associate Professor of Psychology and Radiology Turhan Canli,Turhan Canli
Publisher : Oxford University Press, USA
Release : 2015-01-09
ISBN : 0199753881
Language : En, Es, Fr & De

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Book Description :

This entry in the Oxford Library of Psychology compiles cutting- edge research organized around the concept "molecular psychology," which applies principles of molecular biology to the study of behavior and its neural underpinnings. Determining the biological bases for behavior, and the extent to which we can observe and explain their neural underpinnings, requires a bold, broadly defined research methodology. The interdisciplinary entries in this handbook are organized around the principle of "molecular psychology," which unites cutting-edge research from such wide-ranging disciplines as clinical neuroscience and genetics, psychology, behavioral neuroscience, and neuroethology. For the first time in a single volume, leaders in diverse research areas use molecular approaches to investigate social behavior, psychopathology, emotion, cognition and stress in healthy volunteers, patient populations, and an array of non-human species including rodents, insects, fish, and non-human primates. Chapters draw on molecular methods covering candidate genes, genome-wide association studies, copy number variations, gene expression studies, and epigenetics while addressing the ethical, legal, and social issues to emerge from this new and exciting research approach.