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Epigenetics In Human Disease

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Epigenetics in Human Disease

Epigenetics in Human Disease Book
Author : Trygve O. Tollefsbol
Publisher : Academic Press
Release : 2012
ISBN : 0123884152
Language : En, Es, Fr & De

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Book Description :

Epigenetics is one of the fastest growing fields of sciences, illuminating studies of human diseases by looking beyond genetic make-up and acknowledging that outside factors play a role in gene expression. The goal of this volume is to highlight those diseases or conditions for which we have advanced knowledge of epigenetic factors such as cancer, autoimmune disorders and aging as well as those that are yielding exciting breakthroughs in epigenetics such as diabetes, neurobiological disorders and cardiovascular disease. Where applicable, attempts are made to not only detail the role of epigenetics in the etiology, progression, diagnosis and prognosis of these diseases, but also novel epigenetic approaches to the treatment of these diseases. Chapters are also presented on human imprinting disorders, respiratory diseases, infectious diseases and gynecological and reproductive diseases. Since epigenetics plays a major role in the aging process, advances in the epigenetics of aging are highly relevant to many age-related human diseases. Therefore, this volume closes with chapters on aging epigenetics and breakthroughs that have been made to delay the aging process through epigenetic approaches. With its translational focus, this book will serve as valuable reference for both basic scientists and clinicians alike. Comprehensive coverage of fundamental and emergent science and clinical usage Side-by-side coverage of the basis of epigenetic diseases and their treatments Evaluation of recent epigenetic clinical breakthroughs

Exam Prep for Epigenetics in Human Disease

Exam Prep for  Epigenetics in Human Disease Book
Author : Anonim
Publisher : Unknown
Release : 2021-05-16
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Exam Prep for Epigenetics in Human Disease book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Computational Epigenetics and Diseases

Computational Epigenetics and Diseases Book
Author : Anonim
Publisher : Academic Press
Release : 2019-02-06
ISBN : 0128145145
Language : En, Es, Fr & De

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Book Description :

Computational Epigenetics and Diseases, written by leading scientists in this evolving field, provides a comprehensive and cutting-edge knowledge of computational epigenetics in human diseases. In particular, the major computational tools, databases, and strategies for computational epigenetics analysis, for example, DNA methylation, histone modifications, microRNA, noncoding RNA, and ceRNA, are summarized, in the context of human diseases. This book discusses bioinformatics methods for epigenetic analysis specifically applied to human conditions such as aging, atherosclerosis, diabetes mellitus, schizophrenia, bipolar disorder, Alzheimer disease, Parkinson disease, liver and autoimmune disorders, and reproductive and respiratory diseases. Additionally, different organ cancers, such as breast, lung, and colon, are discussed. This book is a valuable source for graduate students and researchers in genetics and bioinformatics, and several biomedical field members interested in applying computational epigenetics in their research. Provides a comprehensive and cutting-edge knowledge of computational epigenetics in human diseases Summarizes the major computational tools, databases, and strategies for computational epigenetics analysis, such as DNA methylation, histone modifications, microRNA, noncoding RNA, and ceRNA Covers the major milestones and future directions of computational epigenetics in various kinds of human diseases such as aging, atherosclerosis, diabetes, heart disease, neurological disorders, cancers, blood disorders, liver diseases, reproductive diseases, respiratory diseases, autoimmune diseases, human imprinting disorders, and infectious diseases

Nutrition Epigenetic Mechanisms and Human Disease

Nutrition  Epigenetic Mechanisms  and Human Disease Book
Author : Nilanjana Maulik,Gautam Maulik
Publisher : CRC Press
Release : 2010-12-03
ISBN : 1439804826
Language : En, Es, Fr & De

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Book Description :

As nutrition research is shifting its focus from epidemiology and physiology to effects of nutrients at the molecular level, a uniquely tailored diet that corresponds to the demands of our genetic signature is emerging as an indispensable need. Using high-throughput genomic tools, nutrigenomics unravels the influence of micro- and macronutrients as

DNA Methylation and Complex Human Disease

DNA Methylation and Complex Human Disease Book
Author : Michel Neidhart
Publisher : Academic Press
Release : 2015-08-11
ISBN : 0127999205
Language : En, Es, Fr & De

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Book Description :

DNA Methylation and Complex Human Disease reviews the possibilities of methyl-group-based epigenetic biomarkers of major diseases, tailored epigenetic therapies, and the future uses of high-throughput methylome technologies. This volume includes many pertinent advances in disease-bearing research, including obesity, type II diabetes, schizophrenia, and autoimmunity. DNA methylation is also discussed as a plasma and serum test for non-invasive screening, diagnostic and prognostic tests, as compared to biopsy-driven gene expression analysis, factors which have led to the use of DNA methylation as a potential tool for determining cancer risk, and diagnosis between benign and malignant disease. Therapies are at the heart of this volume and the possibilities of DNA demethylation. In cancer, unlike genetic mutations, DNA methylation and histone modifications are reversible and thus have shown great potential in the race for effective treatments. In addition, the authors present the importance of high-throughput methylome analysis, not only in cancer, but also in non-neoplastic diseases such as rheumatoid arthritis. Discusses breaking biomarker research in major disease families of current health concern and research interest, including obesity, type II diabetes, schizophrenia, and autoimmunity Summarizes advances not only relevant to cancer, but also in non-neoplastic disease, currently an emerging field Describes wholly new concepts, including the linking of metabolic pathways with epigenetics Provides translational researchers with the knowledge of both basic research and clinic applications of DNA methylation in human diseases

Epigenetics

Epigenetics Book
Author : C. David Allis
Publisher : CSHL Press
Release : 2007-01
ISBN : 0879697245
Language : En, Es, Fr & De

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Book Description :

The regulation of gene expression in many biological processes involves epigenetic mechanisms. In this new volume, 24 chapters written by experts in the field discuss epigenetic effects from many perspectives. There are chapters on the basic molecular mechanisms underpinning epigenetic regulation, discussion of cellular processes that rely on this kind of regulation, and surveys of organisms in which it has been most studied. Thus, there are chapters on histone and DNA methylation, siRNAs and gene silencing; X-chromosome inactivation, dosage compensation and imprinting; and discussion of epigenetics in microbes, plants, insects, and mammals. The last part of the book looks at how epigenetic mechanisms act in cell division and differentiation, and how errors in these pathways contribute to cancer and other human diseases. Also discussed are consequences of epigenetics in attempts to clone animals. This book is a major resource for those working in the field, as well as being a suitable text for advanced undergraduate and graduate courses on gene regulation.

Epigenetics of Infectious Diseases

Epigenetics of Infectious Diseases Book
Author : Walter Doerfler,Josep Casadesús
Publisher : Springer
Release : 2017-06-24
ISBN : 3319550217
Language : En, Es, Fr & De

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Book Description :

The present volume of Epigenetics and Human Health is devoted to the patho-epigenetics of viral and microbial infections, an exiting new field of disease-related epigenetic research. As recognized during the past years, epigenetic reprogramming of pathogen and host genome functions – the latter frequently induced by pathogens – plays an important role in many infectious processes. Beyond their immediate relevance for pathogen proliferation and obligatorily associated symptoms, such alterations frequently contribute to severe additional complications, such as the development of immunodeficiency, cancer and various chronic disorders. This holds in particular for epigenetic dysregulation of host gene expression induced by latent infections. The present book summarizes current knowledge of the mechanisms underlying epigenetic changes caused by viral, bacterial, fungal and protozoan infections and their impact on human health.

Epigenetics and Human Health

Epigenetics and Human Health Book
Author : Alexander Haslberger,Sabine Greßler
Publisher : John Wiley & Sons
Release : 2011-08-24
ISBN : 352764475X
Language : En, Es, Fr & De

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Book Description :

After first introducing the concept of epigenetics, this handbook and ready reference provides an overview of the main research on epigenetics. It adopts a multidisciplinary approach, involving molecular biology, molecular epidemiology and nutritional science, with a special focus of the book is on disease prevention and treatment. Of interest to all healthcare-related professionals as well as nutritionists, and the medical community focusing on disease prevention.

Epigenetics in Cardiac Disease

Epigenetics in Cardiac Disease Book
Author : Johannes Backs,Timothy A. McKinsey
Publisher : Springer
Release : 2016-11-21
ISBN : 3319414577
Language : En, Es, Fr & De

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Book Description :

This book describes important advances in our understanding of how environmental conditions affect cardiac gene expression through epigenetic mechanisms. Further, it discusses the roles of chromatin modifications (in particular DNA methylation and histone modifications) and of chromatin regulators in the context of cardiac diseases. The book provides readers with an overview of our current understanding of epigenetic regulation in the heart, and will stimulate further research in this exciting field. Edited and written by internationally respected experts, it addresses the needs of professors, students and researchers working in the fields of cardiac biology and epigenetics.

Nature Encyclopedia of the Human Genome Genome databases Mitochondrial genome Evolution

Nature Encyclopedia of the Human Genome  Genome databases   Mitochondrial genome  Evolution Book
Author : David Neil Cooper
Publisher : Unknown
Release : 2003
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

The recent completion of important phases of the Human Genome Project heralds a new era in biomedical research, ensuring that human genetics will remain at the forefront of the public, scientific and educational consciousness. 'The Nature Encyclopedia of the Human Genome' (Nature EHG) will be the first major reference resource devoted entirely to the scientific basis and ethical, philosophical and commercial ramifications of genome research. Nature EHG will contain 1,000 articles, specially written by the world's leading experts and structured in such a way that different subsets will be useful to students, teachers, academics, researchers, and other professionals. The articles will be extensively cross-referenced and indexed and will contain many tables and illustrations. Areas to be covered include structural genomics, functional genomics, evolution and comparative genomics, genome mapping and sequencing, chromosome structure and function, population and mathematical genetics, bioinformatics, proteomics, genes and disease, behavioural and psychiatric genetics and ethical, legal and social issues.

Nutrition and Epigenetics

Nutrition and Epigenetics Book
Author : Emily Ho,Frederick Domann
Publisher : CRC Press
Release : 2014-10-16
ISBN : 1482203812
Language : En, Es, Fr & De

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Book Description :

Nutrition and Epigenetics presents new information on the action of diet and nutritional determinants in regulating the epigenetic control of gene expression in health and disease. Each chapter gives a unique perspective on a different nutritional or dietary component or group of components, and reveals novel mechanisms by which dietary factors modulate the epigenome and affect development processes, chronic disease, and the aging process. This pivotal text: Documents the epigenetic effect of antioxidants and their health benefits Adds to the understanding of mechanisms leading to disease susceptibility and healthy aging Illustrates that the epigenetic origins of disease occur in early (fetal) development Synthesizes the data regarding nutrient and epigenomic interactions Nutrition and Epigenetics highlights the interactions among nutrients, epigenetics, and health, providing an essential resource for scientists and clinical researchers interested in nutrition, aging, and metabolic diseases.

Epigenetics Disease and Behaviour

Epigenetics  Disease and Behaviour Book
Author : Hans J. Lipps,Jan Postberg,Dean A. Jackson
Publisher : Chihuly Workshop
Release : 2010-01-01
ISBN : 9781855781795
Language : En, Es, Fr & De

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Book Description :

Epigenetic mechanisms provide a series of regulatory principles that define potentially stable and heritable changes in gene expression without altering the genetic information that is encoded within DNA. In understanding how epigenetic regulation defines cell type, it may also define patterns of gene expression that correlate with changes in behaviour and disease. The study of epigenetics reveals the complexity of regulatory mechanisms that control gene expression. This volume of Essays in Biochemistry provides an appraisal of the fundamental principles that facilitate the epigenetic regulation of chromatin function, with particular attention on the relevance to human disease and behaviour.

Transgenerational Epigenetics

Transgenerational Epigenetics Book
Author : Trygve Tollefsbol
Publisher : Academic Press
Release : 2019-08-15
ISBN : 9780128163634
Language : En, Es, Fr & De

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Book Description :

Recent research points to the existence of biological phenomena that are controlled not through gene mutations, but rather reversible and heritable epigenetic processes. These processes may have selective or adverse effects on offspring persisting for multiple generations. Transgenerational Epigenetics, Second Edition offers the only up-to-date, comprehensive analysis of the inheritance of epigenetic phenomena between generations with emphasis on human disease relevance, drug discovery, and next steps in clinical translation. Here, international experts discuss mechanisms of epigenetic inheritance, its expression in animal and plant models, and how human ailments, such as metabolic disorders and cardiovascular disease, are influenced by transgenerational epigenetic inheritance. Where evidence is sufficient, epigenetic clinical interventions are proposed that may help prevent disease before the offspring are born, or reduce the severity of disease at the very earliest stages of development in utero. This edition has been thoroughly revised in each disease area, featuring newly researched actors in epigenetic regulation, including long noncoding RNA in addition to histone modifications and DNA methylation. Therapeutic pathways in treating cancer and extending human longevity are also considered, as well as current debates and future directions for research. Fully updated and expanded to address human disease relevance of transgenerational epigenetics, epigenetic mechanisms of gene regulation, and the role of epigenetics in human longevity and cancer Examines the field from "bench-to-bedside," discussing basic science, disease management, current debates, and next steps in epigenetic research and drug discovery Features chapter contributions from international experts

Epigenetic Gene Expression and Regulation

Epigenetic Gene Expression and Regulation Book
Author : Suming Huang,Michael D Litt,C. Ann Blakey
Publisher : Academic Press
Release : 2015-10-19
ISBN : 0128004711
Language : En, Es, Fr & De

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Book Description :

Epigenetic Gene Expression and Regulation reviews current knowledge on the heritable molecular mechanisms that regulate gene expression, contribute to disease susceptibility, and point to potential treatment in future therapies. The book shows how these heritable mechanisms allow individual cells to establish stable and unique patterns of gene expression that can be passed through cell divisions without DNA mutations, thereby establishing how different heritable patterns of gene regulation control cell differentiation and organogenesis, resulting in a distinct human organism with a variety of differing cellular functions and tissues. The work begins with basic biology, encompasses methods, cellular and tissue organization, topical issues in epigenetic evolution and environmental epigenesis, and lastly clinical disease discovery and treatment. Each highly illustrated chapter is organized to briefly summarize current research, provide appropriate pedagogical guidance, pertinent methods, relevant model organisms, and clinical examples. Reviews current knowledge on the heritable molecular mechanisms that regulate gene expression, contribute to disease susceptibility, and point to potential treatment in future therapies Helps readers understand how epigenetic marks are targeted, and to what extent transgenerational epigenetic changes are instilled and possibly passed onto offspring Chapters are replete with clinical examples to empower the basic biology with translational significance Offers more than 100 illustrations to distill key concepts and decipher complex science

Environmental Epigenomics in Health and Disease

Environmental Epigenomics in Health and Disease Book
Author : Randy L Jirtle,Frederick L. Tyson
Publisher : Springer Science & Business Media
Release : 2013-05-16
ISBN : 3642233805
Language : En, Es, Fr & De

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Book Description :

There are now compelling human epidemiological and animal experimental data that indicate the risk of developing adult-onset complex diseases and neurological disorders are influenced by persistent epigenetic adaptations in response to prenatal and early postnatal exposures to environmental factors. Epigenetics refers to heritable changes in gene function that occur without a change in the sequence of the DNA. The main components of the epigenetic code are DNA methylation, histone modifications, and non-coding RNAs. The epigenetic programs are established as stem cell differentiate during embryogenesis, and they are normally faithfully reproduced during mitosis. Moreover, they can also be maintained during meiosis, resulting in epigenetic transgenerational disease inheritance, and also potentially introducing phenotypic variation that is selected for in the evolution of new species. The objective of this book is to provide evidence that environmental exposures during early development can alter the risk of developing medical conditions, such as asthma, autism, cancer, cardiovascular disease, diabetes, obesity, and schizophrenia later in life by modifying the epigenome.

Handbook of Epigenetics

Handbook of Epigenetics Book
Author : Trygve Tollefsbol
Publisher : Academic Press
Release : 2010-11-21
ISBN : 9780123757104
Language : En, Es, Fr & De

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Book Description :

Epigenetics is considered by many to be the "new genetics" because of the overwhelming evidence of the contribution of non-genetic factors such as nutrition, environment, and chemical exposure on gene expression. The effects of epigenetics are vast, including tissue/organ regeneration, X-chromosome inactivation, and stem cell differentiation and genomic imprinting and aging. Aberrations of epigenetics influence many diseases for which clinical intervention is already in place, and many novel epigenetic therapies for cancer, immune disorders, neurological and metabolic disorders, and imprinting diseases are on the horizon. This comprehensive collection of reviews written by leaders in the field of epigenetics provides a broad view of this important and evolving topic. From molecular mechanisms and epigenetic technology to discoveries in human disease and clinical epigenetics, the nature and applications of the science will be presented for those with interests ranging from the fundamental basis of epigenetics to therapeutic interventions for epigenetic-based disorders. Contributions by leading international investigators involved in molecular research and clinical and therapeutic applications Integrates methods and biological topics with basic and clinical discoveries Includes coverage of new topics in epigenetics such as prions, regulation of long-term memory by epigenetics, metabolic aspects of epigenetics, and epigenetics of neuronal disorders

Gene Regulation Epigenetics and Hormone Signaling

Gene Regulation  Epigenetics and Hormone Signaling Book
Author : Subhrangsu S. Mandal
Publisher : John Wiley & Sons
Release : 2017-10-23
ISBN : 3527322817
Language : En, Es, Fr & De

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Book Description :

The first of its kind, this reference gives a comprehensive but concise introduction to epigenetics before covering the many interactions between hormone regulation and epigenetics at all levels. The contents are very well structured with no overlaps between chapters, and each one features supplementary material for use in presentations. Throughout, major emphasis is placed on pathological conditions, aiming at the many physiologists and developmental biologists who are familiar with the importance and mechanisms of hormone regulation but have a limited background in epigenetics.

The Penguin Dictionary of Human Biology

The Penguin Dictionary of Human Biology Book
Author : Michael Thain
Publisher : Penguin Global
Release : 2009
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Enhanced by illustrations and diagrams, offers over seven thousand entries spanning human physiology, biochemistry, genetics, cell biology, immunology, and disease.

Genome Research

Genome Research Book
Author : Anonim
Publisher : Unknown
Release : 2009
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Genome Research book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

International Journal of Oncology

International Journal of Oncology Book
Author : Anonim
Publisher : Unknown
Release : 2007
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download International Journal of Oncology book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.