Skip to main content

Epigenetics In Cardiovascular Disease

In Order to Read Online or Download Epigenetics In Cardiovascular Disease Full eBooks in PDF, EPUB, Tuebl and Mobi you need to create a Free account. Get any books you like and read everywhere you want. Fast Download Speed ~ Commercial & Ad Free. We cannot guarantee that every book is in the library!

Epigenetics in Cardiac Disease

Epigenetics in Cardiac Disease Book
Author : Johannes Backs,Timothy A. McKinsey
Publisher : Springer
Release : 2016-11-21
ISBN : 3319414577
Language : En, Es, Fr & De

GET BOOK

Book Description :

This book describes important advances in our understanding of how environmental conditions affect cardiac gene expression through epigenetic mechanisms. Further, it discusses the roles of chromatin modifications (in particular DNA methylation and histone modifications) and of chromatin regulators in the context of cardiac diseases. The book provides readers with an overview of our current understanding of epigenetic regulation in the heart, and will stimulate further research in this exciting field. Edited and written by internationally respected experts, it addresses the needs of professors, students and researchers working in the fields of cardiac biology and epigenetics.

Epigenetics in Cardiovascular Disease

Epigenetics in Cardiovascular Disease Book
Author : Yvan Devaux,Emma Louise Robinson
Publisher : Academic Press
Release : 2021-03-06
ISBN : 012822259X
Language : En, Es, Fr & De

GET BOOK

Book Description :

Epigenetics in Cardiovascular Disease, a new volume in the Translational Epigenetics series, offers a comprehensive overview of the epigenetics mechanisms governing cardiovascular disease development, as well as instructions in research methods and guidance in pursing new studies. More than thirty international experts provide an (i) overview of the epigenetics mechanisms and their contribution to cardiovascular disease development, (i) high-throughput methods for RNA profiling including single-cell RNA-seq, (iii) the role of nucleic acid methylation in cardiovascular disease development, (iv) epigenetic actors as biomarkers and drug targets, (v) and the potential of epigenetics to advance personalized medicine. Here, readers will discover strategies to combat research challenges, improve quality of their epigenetic research and reproducibility of their findings. Additionally, discussion of assay and drug development for personalized healthcare pave the way for a new era of understanding in cardiovascular disease. Offers a thorough overview of role of epigenetics mechanisms in cardiovascular disease Includes guidance to improve research plans, experimental protocols design, quality and reproducibility of results in new epigenetics research Explores biomarkers and drug targets of therapeutic potential to advance personalized healthcare Features chapter contributions from a wide range of international researchers in the field

Programming of Cardiovascular Disease

Programming of Cardiovascular Disease Book
Author : Catherine Margaret Rose
Publisher : Unknown
Release : 2015
ISBN : 0987650XXX
Language : En, Es, Fr & De

GET BOOK

Book Description :

Download Programming of Cardiovascular Disease book written by Catherine Margaret Rose, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Epigenetics in Human Disease

Epigenetics in Human Disease Book
Author : Trygve Tollefsbol
Publisher : Academic Press
Release : 2012-07-26
ISBN : 0123884160
Language : En, Es, Fr & De

GET BOOK

Book Description :

Epigenetics is one of the fastest growing fields of sciences, illuminating studies of human diseases by looking beyond genetic make-up and acknowledging that outside factors play a role in gene expression. The goal of this volume is to highlight those diseases or conditions for which we have advanced knowledge of epigenetic factors such as cancer, autoimmune disorders and aging as well as those that are yielding exciting breakthroughs in epigenetics such as diabetes, neurobiological disorders and cardiovascular disease. Where applicable, attempts are made to not only detail the role of epigenetics in the etiology, progression, diagnosis and prognosis of these diseases, but also novel epigenetic approaches to the treatment of these diseases. Chapters are also presented on human imprinting disorders, respiratory diseases, infectious diseases and gynecological and reproductive diseases. Since epigenetics plays a major role in the aging process, advances in the epigenetics of aging are highly relevant to many age-related human diseases. Therefore, this volume closes with chapters on aging epigenetics and breakthroughs that have been made to delay the aging process through epigenetic approaches. With its translational focus, this book will serve as valuable reference for both basic scientists and clinicians alike. Comprehensive coverage of fundamental and emergent science and clinical usage Side-by-side coverage of the basis of epigenetic diseases and their treatments Evaluation of recent epigenetic clinical breakthroughs

Nutrition Epigenetics and Health

Nutrition  Epigenetics and Health Book
Author : Burdge Graham,Lillycrop Karen
Publisher : World Scientific
Release : 2016-10-07
ISBN : 9813143320
Language : En, Es, Fr & De

GET BOOK

Book Description :

Epigenetics is emerging as an important factor in risk of diseases of global importance including obesity, cardiovascular disease and cancer. Unlike gene polymorphisms which have been the focus of understanding the role of inherited disease susceptibility for some time, epigenetic can be modified by environmental factors, in particular nutrition. Thus research into the role of epigenetics in disease has substantial potential for explaining the impact of the environmental factors such as diet on disease risk. Since epigenetic processes can be modified by nutrition, it may be possible to modify inappropriate epigenetic marks by nutritional interventions to reduce disease risk. This book will explore current understanding of the interaction between nutrition, epigenetics and disease risk, will place this knowledge in the context of global health and discuss the ethical implications of this research.

Computational Epigenetics and Diseases

Computational Epigenetics and Diseases Book
Author : Anonim
Publisher : Academic Press
Release : 2019-02-06
ISBN : 0128145145
Language : En, Es, Fr & De

GET BOOK

Book Description :

Computational Epigenetics and Diseases, written by leading scientists in this evolving field, provides a comprehensive and cutting-edge knowledge of computational epigenetics in human diseases. In particular, the major computational tools, databases, and strategies for computational epigenetics analysis, for example, DNA methylation, histone modifications, microRNA, noncoding RNA, and ceRNA, are summarized, in the context of human diseases. This book discusses bioinformatics methods for epigenetic analysis specifically applied to human conditions such as aging, atherosclerosis, diabetes mellitus, schizophrenia, bipolar disorder, Alzheimer disease, Parkinson disease, liver and autoimmune disorders, and reproductive and respiratory diseases. Additionally, different organ cancers, such as breast, lung, and colon, are discussed. This book is a valuable source for graduate students and researchers in genetics and bioinformatics, and several biomedical field members interested in applying computational epigenetics in their research. Provides a comprehensive and cutting-edge knowledge of computational epigenetics in human diseases Summarizes the major computational tools, databases, and strategies for computational epigenetics analysis, such as DNA methylation, histone modifications, microRNA, noncoding RNA, and ceRNA Covers the major milestones and future directions of computational epigenetics in various kinds of human diseases such as aging, atherosclerosis, diabetes, heart disease, neurological disorders, cancers, blood disorders, liver diseases, reproductive diseases, respiratory diseases, autoimmune diseases, human imprinting disorders, and infectious diseases

Epigenetics in Human Disease

Epigenetics in Human Disease Book
Author : Trygve Tollefsbol
Publisher : Academic Press
Release : 2018-06
ISBN : 9780128122150
Language : En, Es, Fr & De

GET BOOK

Book Description :

Epigenetics is one of the fastest growing fields in biomedical research, illuminating studies of human diseases by looking beyond genetic make-up and acknowledging that outside factors play a role in gene expression. In Epigenetics in Human Disease, Second Edition, leading international researchers examine those diseases or conditions for which we have advanced knowledge of epigenetic mechanisms such as cancer, autoimmune disorders, aging, metabolic disorders, neurobiological disorders, and cardiovascular disease. In addition to detailing the role of epigenetics in the etiology, progression, diagnosis, and prognosis of these diseases, novel epigenetic approaches to treatment are also explored. Fully revised and up-to-date, this new edition discusses topics of current interest in epigenetic research, including stem cell epigenetic therapy, bioinformatic analysis of NGS data, epigenetic mechanisms of imprinting disorders, online epigenetic tools and data sets, early-life programming of epigenetics in age-related diseases, and epigenetics of addiction and suicide, as well as epigenetic approaches to regulating and preventing diabetes, cardiac disease, allergic disorders, Alzheimer's disease, respiratory diseases, and many other human maladies. With its translational focus, Epigenetics in Human Disease, Second Edition, serves as an invaluable reference for both basic scientists and clinicians alike Includes contributions by leading international investigators involved in translational epigenetic research and therapeutic applications Integrates methods and applications with fundamental chapters on epigenetics in human disease, as well as evaluation of recent epigenetic clinical breakthroughs Side-by-side coverage of the basis of epigenetic diseases and treatment pathways This new edition has been fully revised to cover current developments in disease epigenetics, including stem cell epigenetic therapy, bioinformatic analysis of NGS data, epigenetic mechanisms of imprinting disorders, online epigenetic tools and data sets, early-life programming of epigenetics in age-related diseases, and epigenetics of addiction and suicide, as well as epigenetic approaches to regulating and preventing diabetes, cardiac disease, allergic disorders, Alzheimer's disease, respiratory diseases, and many other human maladies

Epigenetics of Coronary Artery Disease

Epigenetics of Coronary Artery Disease Book
Author : Annie Jane Stevenson
Publisher : Unknown
Release : 2018
ISBN : 0987650XXX
Language : En, Es, Fr & De

GET BOOK

Book Description :

Download Epigenetics of Coronary Artery Disease book written by Annie Jane Stevenson, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Environmental Epigenomics in Health and Disease

Environmental Epigenomics in Health and Disease Book
Author : Randy L Jirtle,Frederick L. Tyson
Publisher : Springer Science & Business Media
Release : 2013-05-16
ISBN : 3642233805
Language : En, Es, Fr & De

GET BOOK

Book Description :

There are now compelling human epidemiological and animal experimental data that indicate the risk of developing adult-onset complex diseases and neurological disorders are influenced by persistent epigenetic adaptations in response to prenatal and early postnatal exposures to environmental factors. Epigenetics refers to heritable changes in gene function that occur without a change in the sequence of the DNA. The main components of the epigenetic code are DNA methylation, histone modifications, and non-coding RNAs. The epigenetic programs are established as stem cell differentiate during embryogenesis, and they are normally faithfully reproduced during mitosis. Moreover, they can also be maintained during meiosis, resulting in epigenetic transgenerational disease inheritance, and also potentially introducing phenotypic variation that is selected for in the evolution of new species. The objective of this book is to provide evidence that environmental exposures during early development can alter the risk of developing medical conditions, such as asthma, autism, cancer, cardiovascular disease, diabetes, obesity, and schizophrenia later in life by modifying the epigenome.

Personalized Epigenetics

Personalized Epigenetics Book
Author : Trygve Tollefsbol
Publisher : Academic Press
Release : 2015-04-28
ISBN : 0128004363
Language : En, Es, Fr & De

GET BOOK

Book Description :

Personalized Epigenetics discusses the core translatability of epigenetics to health management of individuals who have unique variations in their epigenetic signatures that can guide both disorder and disease prevention and therapy. The book details inter-individual variability in the major epigenetic process in humans consisting of DNA methylation, histone modifications, and noncoding RNA, and the diagnostic, prognostic, and therapeutic potential of the field, it also reviews the impact of the environment on epigenetic variations among individuals and the role of pharmacology and drug development in personalized epigenetics. Most importantly, the text covers personalized epigenetics from a disease-oriented perspective, presenting chapters that provide advances in widespread disorders or diseases, including diabetes, cancer, autoimmune disorders, obesity, cardiovascular diseases, neurological disorders, and pain management. Discusses the core translatability of epigenetics to health management of individuals who have unique variations in their epigenetic signatures Details inter-individual variability in the major epigenetic process in humans consisting of DNA methylation, histone modifications, and noncoding RNA, and the consequent diagnostic, prognostic and therapeutic potential of the field Reviews the impact of the environment on epigenetic variations among individuals and the roles of pharmacology and drug development Devotes several chapters to the advances made in widespread disorders or diseases, including diabetes, cancer, autoimmune disorders, obesity, cardiovascular diseases, neurological disorders, and pain management

Molecular mechanisms and physiology of disease

Molecular mechanisms and physiology of disease Book
Author : Nilanjana Maulik,Tom Karagiannis
Publisher : Springer
Release : 2014-05-31
ISBN : 1493907069
Language : En, Es, Fr & De

GET BOOK

Book Description :

In a simplified form, epigenetics refers to heritable changes in phenotype that are not due to changes in the underlying DNA sequence. In this book, epigenetic mechanisms of regulation and dysregulation in health and disease are explored in great depth. Detailed chapters on epigenetic processes including DNA methylation and chromatin post-translational modifications including potential interventions with DNA methyltransferase inhibitors and histone deacetylase inhibitors are explored in initial chapters. These provide a detailed overview and important background to the entire field. The book is then focussed on epigenetic mechanisms involved in various diseases including anti-inflammatory and autoimmune conditions. Important accounts relating to the effects of epigenetics in metabolic syndrome, cardiovascular disease and asthma are the focus of subsequent chapters. The role of epigenetic dysregulation in malignancy is a current topic of interest and represents an intense field of research. A large component of this book is dedicated to the analysis of aberrant epigenetic processes in carcinogenesis and cancer progression. Further, chapters are focused on emerging cancer prevention using nutritional components and anti-cancer therapies particularly with histone deacetylase inhibitors, which have already been approved for the treatment of cutaneous T-cell lymphoma. The emerging role of nanoparticle preparations, especially in the context of delivering potential epigenetic therapies to target cells in various diseases, is also explored in this book. Overall, this book encompasses a wide range of topics related to epigenetic mechanisms in health and disease and would appeal to anyone with an interest in epigenetics, chromatin biology and emerging epigenetic interventions and therapies.

Epigenetic Programming of Cardiovascular Disease by Perinatal Hypoxia and Fetal Growth Restriction

Epigenetic Programming of Cardiovascular Disease by Perinatal Hypoxia and Fetal Growth Restriction Book
Author : Paola Casanello
Publisher : Unknown
Release : 2017
ISBN : 0987650XXX
Language : En, Es, Fr & De

GET BOOK

Book Description :

Most of the worldwide deaths in patients with non-communicable diseases are due to cardiovascular and metabolic diseases, which are determined by a mix of environmental, genetic and epigenetic factors, and by their interactions. The aetiology of most cardiovascular diseases has been partially linked with in utero adverse conditions that may increase the risk of developing diseases later in life, known as Developmental Origins of Health and Disease (DOHaD). Perinatal hypoxia can program the fetal and postnatal developmental patterns, resulting in permanent modifications of cells, organs and systems function. In spite of the vast evidence obtained from human and animal studies linking development under adverse intrauterine conditions with increased cardiovascular risk, still few is known about the specific effects of intrauterine oxygen deficiency and the related pathogenic mechanisms. Currently, the most accepted processes that program cellular function are epigenetic mechanisms which determine gene expression in a cell-specific fashion. In this chapter we will review the current literature regarding the perinatal exposure to chronic hypoxia and Fetal Growth Restriction (FGR) in humans and animals and how this impinges the cardiovascular physiology through epigenetic, biochemical, morphologic and pathophysiologic modifications that translate into diseases blasting at postnatal life.

Translating Epigenetics to the Clinic

Translating Epigenetics to the Clinic Book
Author : Jeffrey Laurence
Publisher : Academic Press
Release : 2016-12-30
ISBN : 0128006129
Language : En, Es, Fr & De

GET BOOK

Book Description :

Translating Epigenetics to the Clinic reviews current methodological tools and experimental approaches used by leading translational researchers seeking to use epigenetics as a clinical model. It organizes epigenetics into disease treatment areas with a major focus on oncology, and with much coverage of pervasive treatment categories such as diabetes, as well as the ‘diseases of modernity’—including pharmacological addiction, dementia, and ageing. Pedagogically, the work concentrates on the latest knowledge, laboratory techniques, and experimental approaches used by translational research leaders in this field. The book promotes cross-disciplinary communication between the sub-specialties of medicine. In common with the rest of the books in Translational Medicine, the book remains unified in theme by emphasizing recent innovations, critical barriers to progress, and the new tools being used to overcome them. Also includes specific areas of research that require additional study to advance the field as a whole. Encompasses the latest innovations and tools being used to apply epigenetics in the lab and clinic Features extensive pedagogical updates aiming to improve the education of translational researchers in this field Offers a transdisciplinary approach to support cross-fertilization between different sub-specialties of medicine

Environmental Epigenomics in Health and Disease

Environmental Epigenomics in Health and Disease Book
Author : Randy L. Jirtle,Frederick L. Tyson
Publisher : Springer Science & Business Media
Release : 2013-05-13
ISBN : 3642368271
Language : En, Es, Fr & De

GET BOOK

Book Description :

There are now compelling human epidemiological and animal experimental data that indicate the risk of developing adult-onset complex diseases and neurological disorders are influenced by persistent epigenetic adaptations in response to prenatal and early postnatal exposures to environmental factors. Epigenetics refers to heritable changes in gene function that occur without a change in the sequence of the DNA. The main components of the epigenetic code are DNA methylation, histone modifications, and non-coding RNAs. The epigenetic programs are established as stem cell differentiate during embryogenesis, and they are normally faithfully reproduced during mitosis. Moreover, they can also be maintained during meiosis, resulting in epigenetic transgenerational disease inheritance, and also potentially introducing phenotypic variation that is selected for in the evolution of new species. The objective of this two volume book is to provide evidence that environmental exposures during early development can alter the risk of developing medical conditions, such as asthma, autism, cancer, cardiovascular disease, diabetes, obesity, and schizophrenia later in life by modifying the epigenome. Consequently, epigenetic research promises to markedly improve our ability to diagnosis, prevent, and treat the pathological conditions of humans; however, it also introduces unique legal and ethical issues. This volume highlights the correlation between environmental factors and complex diseases, such as autism, addiction, neurological diseases, diabetes, obesity and cancer. It concludes with a chapter on legal and ethical implications of epigenetics. ​

Epigenetic Regulators of Cardiac Hypertrophy and Failure

Epigenetic Regulators of Cardiac Hypertrophy and Failure Book
Author : Shanxi Jiang
Publisher : Unknown
Release : 2018
ISBN : 0987650XXX
Language : En, Es, Fr & De

GET BOOK

Book Description :

Under pathological stress, an otherwise healthy heart may enter hypertrophy, a partially-reversible, compromised state wherein heart function is relatively normal although the muscle cells increase in size. Should the stress continue, however, the heart will succumb to the irreversible condition of heart failure, resulting in an inability to efficaciously pump enough blood to support bodily demands. When the heart enters states of either hypertrophy or failure, noticeable changes in chromatin accessibility and gene expression arise. Chromatin accessibility can be defined by a binary chromatin state model: heterochromatin is tightly packed and contains silenced genes, while the relatively loose conformation of euchromatin is more conductive to active gene transcription. Alternations in gene expression or epigenetic regulation are revealed using high-throughput sequencing techniques, which have been developed and rigorously applied over the last two decades. How the principles revealed from studies of chromatin impact gene expression levels in the diseased heart is unknown. My dissertation studied the role of multiple chromatin regulator factors, as studied by high-throughput sequencing techniques, contribute to function of the normal and diseased heart. Those factors include a histone modifying enzyme, a nucleosome remodeling protein, circular RNAs and DNA methylation. The first two chapters of my dissertation detail the functions of two chromatin remodelers identified by quantitative proteomics using mouse hypertrophy and heart failure models: Smyd1, a histone methyltransferase coding gene containing the SET and MYND domains, and Napl14, nucleosome assembly protein 1-like 4. Chapter 1 reports that the chromatin-binding protein Smyd1 restricts adult mammalian heart growth. Mice with induced knockdown of cardiac-specific Smyd1 displayed cardiomyocyte growth, organ remodeling, and declined heart function. Chapter 2 describes a possible mechanism by which histone chaperone Nap1l4 may regulate cardiac transcription in hypertrophy. As revealed by siRNA knock down, the lack of Nap1l4-mediated transcription reduces the size of neonatal rat ventricular myocytes (NRVMs) and inhibits fetal gene reprogramming induced by phenylephrine (PHE). However, when Nap1l4 is overexpressed, there is an increase in the size of NRVMs. The latter two chapters of the dissertation describe the epigenomic changes revealed by high-throughput sequencing that could potentially affect gene expression during cardiovascular diseases. Chapter 3 explores our utilization of Ribo-Zero RNA sequencing to discover circular RNAs (circRNAs) in the heart using mouse models. We confirmed the existence of cardiac-related circRNAs including circMyocd, circRyr2, and circTtn. With the successful knockdown of circMyocd in NRVMs, we observed increased expression of linear Myocd, indicating the circRNAs may regulate transcription of its linear counterparts. Chapter 4 characterizes DNA methylation alterations in patients undergoing coronary artery bypass grafting (CABG) using reduced representation bisulfite sequencing (RRBS) with respect to post-operative atrial fibrillation (POAF). When comparing pre-operative and post-operative epigenomic states, we found that the hypervariable CpG sites are mostly enriched in or around genes pertaining to the immune system, cellular adhesion and the cardiovascular system. Specifically, altered CpG methylation in genes coding for transforming growth factor-beta 1 (TGF- 1) may be a marker for POAF as well as pre-operative and post-operative epigenomic states. My dissertation revealed that epigenetic changes including chromatin remodelers, DNA methylation and circRNAs could affect the gene expression during heart diseases. The work will undoubtedly benefit the whole community and shed light on the translational medicine for heart failure patients.

Environmental Epigenetics

Environmental Epigenetics Book
Author : L. Joseph Su,Tung-chin Chiang
Publisher : Springer
Release : 2015-05-18
ISBN : 1447166787
Language : En, Es, Fr & De

GET BOOK

Book Description :

This book examines the toxicological and health implications of environmental epigenetics and provides knowledge through an interdisciplinary approach. Included in this volume are chapters outlining various environmental risk factors such as phthalates and dietary components, life states such as pregnancy and ageing, hormonal and metabolic considerations and specific disease risks such as cancer cardiovascular diseases and other non-communicable diseases. Environmental Epigenetics imparts integrative knowledge of the science of epigenetics and the issues raised in environmental epidemiology. This book is intended to serve both as a reference compendium on environmental epigenetics for scientists in academia, industry and laboratories and as a textbook for graduate level environmental health courses. Environmental Epigenetics imparts integrative knowledge of the science of epigenetics and the issues raised in environmental epidemiology. This book is intended to serve both as a reference compendium on environmental epigenetics for scientists in academia, industry and laboratories and as a textbook for graduate level environmental health courses.

Medical Epigenetics

Medical Epigenetics Book
Author : Trygve Tollefsbol
Publisher : Academic Press
Release : 2016-06-21
ISBN : 0128032405
Language : En, Es, Fr & De

GET BOOK

Book Description :

Medical Epigenetics provides a comprehensive analysis of the importance of epigenetics to health management. The purpose of this book is to fill a current need for a comprehensive volume on the medical aspects of epigenetics with a focus on human systems, epigenetic diseases that affect these systems and modes of treating epigenetic-based disorders and diseases. The intent of this book is to provide a stand-alone comprehensive volume that will cover all human systems relevant to epigenetic maladies and all major aspects of medical epigenetics. The overall goal is to provide the leading book on medical epigenetics that will be useful not only to physicians, nurses, medical students and many others directly involved with health care, but also investigators in life sciences, biotech companies, graduate students and many others who are interested in more applied aspects of epigenetics. Research in the area of translational epigenetics is a cornerstone of this volume. Critical reviews dedicated to the burgeoning role of epigenetics in medical practice Coverage of emerging topics including twin epigenetics as well as epigenetics of gastrointestinal disease, muscle disorders, endocrine disorders, ocular medicine, pediatric diseases, sports medicine, noncoding RNA therapeutics, pain management and regenerative medicine Encompasses a disease-oriented perspective of medical epigenetics as well as diagnostic and prognostic epigenetic approaches to applied medicine

Transgenerational Epigenetics

Transgenerational Epigenetics Book
Author : Anonim
Publisher : Academic Press
Release : 2019-05-18
ISBN : 0128167335
Language : En, Es, Fr & De

GET BOOK

Book Description :

Transgenerational Epigenetics, Second Edition, offers the only up-to-date, comprehensive analysis of the inheritance of epigenetic phenomena between generations with an emphasis on human disease relevance, drug discovery, and next steps in clinical translation. International experts discuss mechanisms of epigenetic inheritance, its expression in animal and plant models, and how human ailments, such as metabolic disorders and cardiovascular disease are influenced by transgenerational epigenetic inheritance. Where evidence is sufficient, epigenetic clinical interventions are proposed that may help prevent or reduce the severity of disease before offspring are born. This edition has been thoroughly revised in each disease area, featuring newly researched actors in epigenetic regulation, including long noncoding RNA in addition to histone modifications and DNA methylation. Therapeutic pathways in treating cancer and extending human longevity are also considered, as are current debates and future directions for research. Presents a fully-updated and expanded release addressing transgenerational epigenetics, epigenetic mechanisms of gene regulation, and the role of epigenetics in human longevity and cancer Examines the field from "bench-to-bedside", discussing basic science, disease management, current debates, and next steps in epigenetic research and drug discovery Features chapter contributions from international experts

Endothelium and Cardiovascular Diseases

Endothelium and Cardiovascular Diseases Book
Author : Protasio Lemos Da Luz,Peter Libby,Francisco Rafael Martins Laurindo,Antonio Carlos Palandri Chagas
Publisher : Academic Press
Release : 2018-02-03
ISBN : 0128125519
Language : En, Es, Fr & De

GET BOOK

Book Description :

Endothelium and Cardiovascular Diseases: Vascular Biology and Clinical Syndromes provides an in-depth examination of the role of endothelium and endothelial dysfunction in normal vascular function, and in a broad spectrum of clinical syndromes, from atherosclerosis, to cognitive disturbances and eclampsia. The endothelium is a major participant in the pathophysiology of diseases, such as atherosclerosis, diabetes and hypertension, and these entities are responsible for the largest part of cardiovascular mortality and morbidly. Over the last decade major new discoveries and concepts involving the endothelium have come to light. This important reference collects this data in an easy to reference resource. Written by known experts, and covering all aspects of endothelial function in health and disease, this reference represents an assembly of recent knowledge that is essential to both basic investigators and clinicians. Provides a complete overview of endothelial function in health and diseases, along with an assessment of new information Includes coverage of groundbreaking areas, including the artificial LDL particle, the development of a new anti-erectile dysfunction agent, a vaccine for atherosclerosis, coronary calcification associated with red wine, and the interplay of endoplasmic reticulum/oxidative stress Explores the genetic features of endothelium and the interaction between basic knowledge and clinical syndromes