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Epigenetics And Reproductive Health

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Epigenetics and Reproductive Health

Epigenetics and Reproductive Health Book
Author : Anonim
Publisher : Academic Press
Release : 2020-09-12
ISBN : 0128197544
Language : En, Es, Fr & De

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Book Description :

Epigenetics and Reproductive Health, a new volume in the Translational Epigenetics series, provides a thorough overview and discussion of epigenetics in reproduction and implications for reproductive medicine. Twenty international researchers discuss epigenetic mechanisms operating during the formation of male and female gametes, fertilization and subsequent embryo and placental development, particularly in mammals and transgenerational epigenetic inheritance. This volume also addresses aberrant epigenetic changes influencing male and female infertility, pregnancy related disorders, and those potentially linked to therapeutic manipulations and assisted reproductive technologies. Emphasis is placed on identifying biomarkers for early detection of aberrant epigenetic mechanisms. Later chapters examine the possibility of correcting these epigenetic dysfunctions, as well as current challenges and next steps in research, enabling new translational discoveries and efforts towards developing therapeutics. Thoroughly examines the influence of aberrant epigenetics during gametogenesis and embryogenesis, affecting parents, gametes and embryos, offspring and future generations Explores health outcomes for reproductive senescence, endocrine disruption, testicular cancer, prostrate cancer, breast cancer, ovarian, cancer, endometrial cancer and cervical cancers Features chapter contributions from international researchers in the field

The Epigenome and Developmental Origins of Health and Disease

The Epigenome and Developmental Origins of Health and Disease Book
Author : Cheryl S Rosenfeld
Publisher : Academic Press
Release : 2015-10-10
ISBN : 0128016728
Language : En, Es, Fr & De

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Book Description :

The Epigenome and Developmental Origins of Health and Disease synthesizes the existing knowledge on how the in utero environment could be the most important environment in shaping later risk for various diseases or to conversely promote the health of the offspring. The book mines the existing literature from a variety of disciplines from toxicology to nutrition to epigenetics to reveal how contrasting maternal in utero environmental changes might be leading to epigenetic convergence and the resulting deleterious phenotypic and physiological effects in our offspring. It is increasingly becoming apparent that even subtle changes in the mother’s diet, stress, and exposure to low concentrations of toxic chemicals at levels deemed safe by the EPA and FDA, such as endocrine disrupting compounds (EDC), can dramatically impact the health of our children, possibly leading to metabolic, cardiovascular, immunological, neurobehavioral disorders, and increased risk for cancer to list but a few examples. Informs how everyday choices pregnant women make can impact child development Ties together how in utero environmental changes may be inducing epigenetic changes in the offspring leading to overlapping phenotypes regardless of the initial insult (toxic, nutrition, or stress) Includes a boxed-in area in each chapter for further references and resources to keep up with the field Features video interviews with the authors and other key leaders in the field

Transgenerational Epigenetics

Transgenerational Epigenetics Book
Author : Trygve Tollefsbol
Publisher : Elsevier
Release : 2014-05-02
ISBN : 0124059228
Language : En, Es, Fr & De

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Book Description :

Transgenerational Epigenetics provides a comprehensive analysis of the inheritance of epigenetic phenomena between generations. Recent research points to the existence of biological phenomena that are controlled not through gene mutations, but rather through reversible and heritable epigenetic processes. Epidemiological studies have suggested that environmental factors may be heritable. In fact, environmental factors often play a role in transgenerational epigenetics, which may have selective or adverse effects on the offspring. This epigenetic information can be transferred through a number of mechanisms including DNA methylation, histone modifications or RNA and the effects can persist for multiple generations. This book examines the evolution of epigenetic inheritance, its expression in animal and plant models, and how human diseases, such as metabolic disorders and cardiovascular diseases, appear to be affected by transgenerational epigenetic inheritance. It discusses clinical interventions in transgenerational epigenetic inheritance that may be on the horizon to help prevent diseases before the offspring are born, or to reduce the severity of diseases at the very earliest stages of development in utero, and current controversies in this area of study, as well as future directions for research. Focused discussion of metabolic disorders, cardiovascular diseases and longevity, which appear most affected by reversible and heritable epigenetic processes Encompasses both foundational and clinical aspects including discussions of preventative in utero therapies Covers history, future outlook, disease management and current controversies

Environmental Epigenetics

Environmental Epigenetics Book
Author : L. Joseph Su,Tung-chin Chiang
Publisher : Springer
Release : 2015-05-18
ISBN : 1447166787
Language : En, Es, Fr & De

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Book Description :

This book examines the toxicological and health implications of environmental epigenetics and provides knowledge through an interdisciplinary approach. Included in this volume are chapters outlining various environmental risk factors such as phthalates and dietary components, life states such as pregnancy and ageing, hormonal and metabolic considerations and specific disease risks such as cancer cardiovascular diseases and other non-communicable diseases. Environmental Epigenetics imparts integrative knowledge of the science of epigenetics and the issues raised in environmental epidemiology. This book is intended to serve both as a reference compendium on environmental epigenetics for scientists in academia, industry and laboratories and as a textbook for graduate level environmental health courses. Environmental Epigenetics imparts integrative knowledge of the science of epigenetics and the issues raised in environmental epidemiology. This book is intended to serve both as a reference compendium on environmental epigenetics for scientists in academia, industry and laboratories and as a textbook for graduate level environmental health courses.

Reproductomics

Reproductomics Book
Author : José A. Horcajadas,Jaime Gosálvez
Publisher : Academic Press
Release : 2018-07-23
ISBN : 0128126760
Language : En, Es, Fr & De

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Book Description :

Recent advances in genomic and omics analysis have triggered a revolution affecting nearly every field of medicine, including reproductive medicine, obstetrics, gynecology, andrology, and infertility treatment. Reproductomics: The –Omics Revolution and Its Impact on Human Reproductive Medicine demonstrates how various omics technologies are already aiding fertility specialists and clinicians in characterizing patients, counseling couples towards pregnancy success, informing embryo selection, and supporting many other positive outcomes. A diverse range of chapters from international experts examine the complex relationship between genomics, transcriptomics, proteomics, and metabolomics and their role in human reproduction, identifying molecular factors of clinical significance. With this book Editors Jaime Gosálvez and José A. Horcajadas have provided researchers and clinicians with a strong foundation for a new era of personalized reproductive medicine. Thoroughly discusses how genomics and other omics approaches aid clinicians in various areas of reproductive medicine Identifies specific genomic and molecular factors of translational value in treating infertility and analyzing patient data Features chapter contributions by leading international experts

Weighing the Future

Weighing the Future Book
Author : Natali Valdez
Publisher : Univ of California Press
Release : 2021-12-14
ISBN : 0520380150
Language : En, Es, Fr & De

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Book Description :

Epigenetics, the study of heritable changes in gene expression, has been heralded as one of the most promising new fields of scientific inquiry. Current large-scale studies selectively draw on epigenetics to connect behavioral choices made by pregnant people, such as diet and exercise, to health risks for future generations. As the first ethnography of its kind, Weighing the Future examines the sociopolitical implications of ongoing pregnancy trials in the United States and the United Kingdom, illuminating how processes of scientific knowledge production are linked to capitalism, surveillance, and environmental reproduction. Natali Valdez argues that a focus on individual behavior rather than social environments ignores the vital impacts of systemic racism. The environments we imagine to shape our genes, bodies, and future health are intimately tied to race, gender, and structures of inequality. This groundbreaking book makes the case that science, and how we translate it, is a reproductive project that requires feminist vigilance. Instead of fixating on a future at risk, this book brings attention to the present at stake.

Textbook of Human Reproductive Genetics

Textbook of Human Reproductive Genetics Book
Author : Karen Sermon,Stéphane Viville
Publisher : Cambridge University Press
Release : 2014-04-10
ISBN : 1107683580
Language : En, Es, Fr & De

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Book Description :

This book brings together genetics, reproductive biology and medicine for an integrative view of the emerging specialism of reproductive genetics.

Epigenetics in Precision Medicine

Epigenetics in Precision Medicine Book
Author : Jose Luis Garcia-Gimenez
Publisher : Elsevier
Release : 2021-11-22
ISBN : 0323858058
Language : En, Es, Fr & De

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Book Description :

In recent years, knowledge of epigenetic mechanisms underlying disease onset and progression has proven crucial for the development of novel early diagnosis and prognosis biomarkers for patient stratification and precision medicine. Epigenetics in Precision Medicine, a new volume in the Translational Epigenetics series, provides a thorough discussion and overview of current developments in clinical epigenetics with special emphasis on epigenetic biomarkers that can be used for clinical diagnosis, prognosis, patient stratification, and treatment monitoring. Disease types discussed include cancer, metabolic disorders, neurodegenerative diseases, bone disease, and immune-related disorders. The book examines the challenges of advancing epigenetics research and translating findings to the clinic and drug discovery in each of these areas, as well as current solutions; chapter authors discuss how to leverage epigenomic technologies, applications, and tools, such as next-generation sequencing, to discover new epigenetic biomarkers in disease and drug studies. Epigenetics in Precision Medicine focuses on complex epigenetic mechanisms in several pathologies, and explores how epigenetics can power the advance of precision medicine, not only by improving in vitro diagnostic and prognostic tools, but by providing new therapeutic approaches to treat human disease. Provides a thorough grounding in epigenetics-driven precision medicine, with emphasis on developing and implementing early diagnosis and prognosis biomarkers, and supporting patient stratification Empowers researchers and clinicians to incorporate epigenetics in new disease research, drug discovery, and clinical practice Features chapter contributions from international leaders in the field

Medical Epigenetics

Medical Epigenetics Book
Author : Anonim
Publisher : Academic Press
Release : 2021-08-27
ISBN : 0128243260
Language : En, Es, Fr & De

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Book Description :

Medical Epigenetics, Second Edition provides a comprehensive analysis of epigenetics in health management, across a broad spectrum of disease categories and specialties, and with a focus on human systems, epigenetic diseases that affect these systems, and evolving modes of epigenetic-based treatment. Here, more than 40 leading researchers examine how each human system is affected by epigenetic maladies, offering an all-in-one resource on medical epigenetics not only for those directly involved with health care, but investigators in life sciences, biotech companies, graduate students, and others who are interested in applied aspects of epigenetics. Incorporating both diagnostic and prognostic epigenetic approaches, this volume also fully supports the application of epigenetics in precision medicine. This second edition of Medical Epigenetics, a volume in the Translational Epigenetics series, has been fully revised to address recent advances in disease epigenetics and role of epigenetics in precision medicine, with all-new chapters on skin cancer epigenetics, network analysis in medical epigenetics, machine learning in epigenetic diseases, and clinical trials of epigenetics drugs. Features chapters from leading researchers and clinicians dedicated to the burgeoning role of epigenetics in medical practice Covers emerging topics, including twin epigenetics, as well as epigenetics of gastrointestinal disease, muscle disorders, endocrine disorders, ocular medicine, pediatric diseases, sports medicine, noncoding RNA therapeutics, pain management and regenerative medicine Organized from system disorders to multi-system disorders that involve epigenetic aberrations Examines the role of epigenetics in precision medicine

Epigenetics in Human Disease

Epigenetics in Human Disease Book
Author : Trygve O. Tollefsbol
Publisher : Academic Press
Release : 2012
ISBN : 0123884152
Language : En, Es, Fr & De

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Book Description :

Epigenetics is one of the fastest growing fields of sciences, illuminating studies of human diseases by looking beyond genetic make-up and acknowledging that outside factors play a role in gene expression. The goal of this volume is to highlight those diseases or conditions for which we have advanced knowledge of epigenetic factors such as cancer, autoimmune disorders and aging as well as those that are yielding exciting breakthroughs in epigenetics such as diabetes, neurobiological disorders and cardiovascular disease. Where applicable, attempts are made to not only detail the role of epigenetics in the etiology, progression, diagnosis and prognosis of these diseases, but also novel epigenetic approaches to the treatment of these diseases. Chapters are also presented on human imprinting disorders, respiratory diseases, infectious diseases and gynecological and reproductive diseases. Since epigenetics plays a major role in the aging process, advances in the epigenetics of aging are highly relevant to many age-related human diseases. Therefore, this volume closes with chapters on aging epigenetics and breakthroughs that have been made to delay the aging process through epigenetic approaches. With its translational focus, this book will serve as valuable reference for both basic scientists and clinicians alike. Comprehensive coverage of fundamental and emergent science and clinical usage Side-by-side coverage of the basis of epigenetic diseases and their treatments Evaluation of recent epigenetic clinical breakthroughs

Developmental Origins of Health and Disease

Developmental Origins of Health and Disease Book
Author : Peter Gluckman,Mark Hanson
Publisher : Cambridge University Press
Release : 2006-04-20
ISBN : 9780521847438
Language : En, Es, Fr & De

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Book Description :

This landmark publication provides the first definitive account of how and why subtle influences on the fetus and during early life can have such profound consequences for adult health and diseases. Although the epidemiological evidence for this link has long proved compelling, it is only much more recently that the scientific and physiological basis has begun to be studied in depth and fully understood. The compilation, written by many of the world's leading experts in this exciting field, summarizes these scientific and clinical advances.

Human Reproductive Genetics

Human Reproductive Genetics Book
Author : Juan A. Garcia-Velasco,Emre Seli
Publisher : Academic Press
Release : 2020-04-19
ISBN : 0128167491
Language : En, Es, Fr & De

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Book Description :

Human Reproductive Genetics: Emerging Technologies and Clinical Applications presents a great reference for clinicians and researchers in reproductive medicine. Part I includes a brief background of genetics and epigenetics, probability of disease, and the different techniques that are being used today for analysis and genetic counseling. Part II focuses on the analysis of the embryo, current controversies and future concepts. Part III comprises different clinical scenarios that clinicians frequently face in practice. The increasing amount of genetic tests available and the growing information that patients handle makes this section a relevant part of the fertility treatment discussion. Finally, Part IV concludes with the psychological aspects of genetic counseling and the role of counselor and bioethics in human reproduction. Provides an essential reference for clinicians involved in reproductive medicine Builds foundational knowledge on new genetic tests coming into the clinical scenario for physicians involved with patients Assembles critically evaluated chapters that cover basic concepts of genetics and epigenetics and the techniques involved, including preimplantation genetic testing, controversies, and more

Handbook of New Genetic Diagnostic Technologies in Reproductive Medicine

Handbook of New Genetic Diagnostic Technologies in Reproductive Medicine Book
Author : Carlos Simón,Carmen Rubio
Publisher : CRC Press
Release : 2017-12-14
ISBN : 1498763316
Language : En, Es, Fr & De

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Book Description :

Different genetic diagnostic and treatment options are used worldwide to improve routine IVF procedures for the benefit of patients. This handbook updates the new genetic diagnostic technologies that have been translated to practice aiming to improve outcomes in the clinic and have a healthy baby at home. Chapters cover the use of genetic technologies in a personalized manner to unravel the possible genetic risks for the couple wishing to conceive, in terms of sperm, the embryo, the endometrium, miscarriage, and finally the fetus.

Innovations In Assisted Reproduction Technology

Innovations In Assisted Reproduction Technology Book
Author : Nidhi Sharma,Sudakshina Chakrabarti,Yona Barak,Adrian Ellenbogen
Publisher : BoD – Books on Demand
Release : 2020-05-06
ISBN : 1838805486
Language : En, Es, Fr & De

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Book Description :

This book deals with all recent advances in clinical and laboratory aspects of assisted reproductive therapy (ART). It elaborates on innovations and developments in the field that have the potential to improve ART outcomes. Chapters cover such topics as newer techniques for evaluating sperm, DNA, and ovarian reserve, including proteomic analysis, sonoendocrinology, preparation and administration of platelet-rich plasma, and in vitro maturation. Authors also address the structure, function, and role of low molecular weight ligands of gonadotropins, as well as the ethical and legal aspects of ART.

Twin and Family Studies of Epigenetics

Twin and Family Studies of Epigenetics Book
Author : Shuai Li,John Hopper,Trygve Tollefsbol
Publisher : Elsevier
Release : 2021-08-30
ISBN : 0128209518
Language : En, Es, Fr & De

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Book Description :

Twin and Family Studies of Epigenetics, Volume 29, the latest release in the Translational Epigenetics series, gathers expert opinions on epigenetic twin and family study research methods, recent findings across various disease areas, and future directions. The book provides in-depth coverage of epigenetics fundamentals, twin and family epigenetic study design, and the broader role of epigenetics in answering questions on the developmental origins of health and disease. Throughout the volume, twin and family studies are employed to examine causes of epigenetic variation, the relationship between epigenetic modifications and mental illness, cancers, cardiovascular disease, diabetes, obesity, high blood pressure, and more. Emerging research methods applied in twin and family studies discussed include imaging epigenetics, exposure-specific DNA methylation changes, and unravelling time trends in epigenetic effects. Offers a practical, interdisciplinary approach across epigenetics, epidemiology and various disease specialties Applies epigenetic twin and family studies to determine the relationship between epigenetics and mental illness, cancers, cardiovascular disease, diabetes, obesity and high blood pressure, among other diseases and disorders Features chapter contributions from a wide range of international researchers in the field

The Maternal Imprint

The Maternal Imprint Book
Author : Sarah S. Richardson
Publisher : University of Chicago Press
Release : 2021-11-08
ISBN : 022680707X
Language : En, Es, Fr & De

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Book Description :

Leading gender and science scholar Sarah S. Richardson charts the untold history of the idea that a woman's health and behavior during pregnancy can have long-term effects on her descendants' health and welfare. The idea that a woman may leave a biological trace on her gestating offspring has long been a commonplace folk intuition and a matter of scientific intrigue, but the form of that idea has changed dramatically over time. Beginning with the advent of modern genetics at the turn of the twentieth century, biomedical scientists dismissed any notion that a mother—except in cases of extreme deprivation or injury—could alter her offspring’s traits. Consensus asserted that a child’s fate was set by a combination of its genes and post-birth upbringing. Over the last fifty years, however, this consensus was dismantled, and today, research on the intrauterine environment and its effects on the fetus is emerging as a robust program of study in medicine, public health, psychology, evolutionary biology, and genomics. Collectively, these sciences argue that a woman’s experiences, behaviors, and physiology can have life-altering effects on offspring development. Tracing a genealogy of ideas about heredity and maternal-fetal effects, this book offers a critical analysis of conceptual and ethical issues—in particular, the staggering implications for maternal well-being and reproductive autonomy—provoked by the striking rise of epigenetics and fetal origins science in postgenomic biology today.

Computational Epigenetics and Diseases

Computational Epigenetics and Diseases Book
Author : Anonim
Publisher : Academic Press
Release : 2019-02-06
ISBN : 0128145145
Language : En, Es, Fr & De

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Book Description :

Computational Epigenetics and Diseases, written by leading scientists in this evolving field, provides a comprehensive and cutting-edge knowledge of computational epigenetics in human diseases. In particular, the major computational tools, databases, and strategies for computational epigenetics analysis, for example, DNA methylation, histone modifications, microRNA, noncoding RNA, and ceRNA, are summarized, in the context of human diseases. This book discusses bioinformatics methods for epigenetic analysis specifically applied to human conditions such as aging, atherosclerosis, diabetes mellitus, schizophrenia, bipolar disorder, Alzheimer disease, Parkinson disease, liver and autoimmune disorders, and reproductive and respiratory diseases. Additionally, different organ cancers, such as breast, lung, and colon, are discussed. This book is a valuable source for graduate students and researchers in genetics and bioinformatics, and several biomedical field members interested in applying computational epigenetics in their research. Provides a comprehensive and cutting-edge knowledge of computational epigenetics in human diseases Summarizes the major computational tools, databases, and strategies for computational epigenetics analysis, such as DNA methylation, histone modifications, microRNA, noncoding RNA, and ceRNA Covers the major milestones and future directions of computational epigenetics in various kinds of human diseases such as aging, atherosclerosis, diabetes, heart disease, neurological disorders, cancers, blood disorders, liver diseases, reproductive diseases, respiratory diseases, autoimmune diseases, human imprinting disorders, and infectious diseases

Weighing the Future

Weighing the Future Book
Author : Natali Valdez
Publisher : Univ of California Press
Release : 2022
ISBN : 0520380134
Language : En, Es, Fr & De

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Book Description :

Epigenetics is the study of heritable changes in gene expression and has been heralded as one of the most promising new fields of scientific inquiry. Current large-scale pregnancy studies draw on epigenetics to connect pregnant women's behavioral choices, like diet and exercise, to future health risks for unborn babies. As the first ethnography of its kind, Weighing the Future examines the sociopolitical implications of ongoing pregnancy trials in the United States and the United Kingdom, illuminating how processes of scientific knowledge production are linked to capitalism, surveillance, and environmental reproduction. The environments we imagine to shape our genes, bodies, and future health are tied to race, gender, and structures of inequality. This groundbreaking book makes the case that science, and how we translate it, is a reproductive project that requires feminist vigilance. Instead of fixating on a future at risk, this book brings attention to the present at stake.

Reproductive Genetics

Reproductive Genetics Book
Author : Sean Kehoe,Lyn Chitty,Tessa Homfray
Publisher : RCOG
Release : 2009-11
ISBN : 1906985162
Language : En, Es, Fr & De

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Book Description :

This book presents the findings of the RCOG Study Group findings on genetics underlying reproductive function.

Epigenetics and Assisted Reproduction

Epigenetics and Assisted Reproduction Book
Author : Cristina Camprubí,Joan Blanco
Publisher : CRC Press
Release : 2018-08-16
ISBN : 1351804448
Language : En, Es, Fr & De

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Book Description :

Epigenetics is the study of how certain genes are activated without modification at the DNA sequence level, resulting in genetically similar individuals having different clinical outcomes. As contemporary medicine increasingly aims to personalize the medical approach to a patient's genetic profile, the factors that can affect which genes are expressed also increase in importance and relevance to the clinician. This text from experts will give the clinician in Reproductive Medicine a reliable grounding in current thinking and research on this fast-moving topic, with many clinical implications.