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Epigenetics in Human Disease

Epigenetics in Human Disease Book
Author : Trygve Tollefsbol
Publisher : Academic Press
Release : 2018-05-18
ISBN : 012812329X
Language : En, Es, Fr & De

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Book Description :

Epigenetics in Human Disease, Second Edition examines the diseases and conditions on which we have advanced knowledge of epigenetic mechanisms, such as cancer, autoimmune disorders, aging, metabolic disorders, neurobiological disorders and cardiovascular disease. In addition to detailing the role of epigenetics in the etiology, progression, diagnosis and prognosis of these diseases, novel epigenetic approaches to treatment are also explored. Fully revised and up-to-date, this new edition discusses topics of current interest in epigenetic research, including stem cell epigenetic therapy, bioinformatic analysis of NGS data, and epigenetic mechanisms of imprinting disorders. Further sections explore online epigenetic tools and datasets, early-life programming of epigenetics in age-related diseases, the epigenetics of addiction and suicide, and epigenetic approaches to regulating and preventing diabetes, cardiac disease, allergic disorders, Alzheimer’s disease, respiratory diseases, and many other human maladies. Includes contributions from leading international investigators involved in translational epigenetic research and therapeutic applications Integrates methods and applications with fundamental chapters on epigenetics in human disease, along with an evaluation of recent clinical breakthroughs Presents side-by-side coverage of the basis of epigenetic diseases and treatment pathways Provides a fully revised resource covering current developments, including stem cell epigenetic therapy, the bioinformatic analysis of NGS data, epigenetic mechanisms of imprinting disorders, online epigenetic tools and datasets, and more

Epigenetics in Health and Disease

Epigenetics in Health and Disease Book
Author : Igor Kovalchuk,Olga Kovalchuk
Publisher : FT Press
Release : 2012
ISBN : 013259708X
Language : En, Es, Fr & De

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Book Description :

"After reviewing the field's history and context, the authors introduce and explain each key epigenetic mechanism. Next, they extensively discuss the roles these mechanisms may play in inheritance, development, health and disease, behavior, evolution, ecology, and the interactions of individual organisms with their environments"--Cover, p. [4].

Medical Epigenetics

Medical Epigenetics Book
Author : Trygve Tollefsbol
Publisher : Academic Press
Release : 2016-06-21
ISBN : 0128032405
Language : En, Es, Fr & De

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Book Description :

Medical Epigenetics provides a comprehensive analysis of the importance of epigenetics to health management. The purpose of this book is to fill a current need for a comprehensive volume on the medical aspects of epigenetics with a focus on human systems, epigenetic diseases that affect these systems and modes of treating epigenetic-based disorders and diseases. The intent of this book is to provide a stand-alone comprehensive volume that will cover all human systems relevant to epigenetic maladies and all major aspects of medical epigenetics. The overall goal is to provide the leading book on medical epigenetics that will be useful not only to physicians, nurses, medical students and many others directly involved with health care, but also investigators in life sciences, biotech companies, graduate students and many others who are interested in more applied aspects of epigenetics. Research in the area of translational epigenetics is a cornerstone of this volume. Critical reviews dedicated to the burgeoning role of epigenetics in medical practice Coverage of emerging topics including twin epigenetics as well as epigenetics of gastrointestinal disease, muscle disorders, endocrine disorders, ocular medicine, pediatric diseases, sports medicine, noncoding RNA therapeutics, pain management and regenerative medicine Encompasses a disease-oriented perspective of medical epigenetics as well as diagnostic and prognostic epigenetic approaches to applied medicine

Epigenetics

Epigenetics Book
Author : Reinhard Heil,Stefanie B. Seitz,Harald König,Jürgen Robienski
Publisher : Springer
Release : 2017-01-31
ISBN : 3658144602
Language : En, Es, Fr & De

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Book Description :

Modern epigenetics unites scientists from life sciences, organic chemistry as well as computer and engineering sciences to find an answer to the question of how environmental influences can have a lasting effect on gene expression, maybe even into the next generations. This volume examines from an interdisciplinary perspective the ethical, legal and social aspects of epigenetics.

Handbook of Epigenetics

Handbook of Epigenetics Book
Author : Trygve Tollefsbol
Publisher : Academic Press
Release : 2017-07-10
ISBN : 0128054778
Language : En, Es, Fr & De

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Book Description :

Handbook of Epigenetics: The New Molecular and Medical Genetics, Second Edition, provides a comprehensive analysis of epigenetics, from basic biology, to clinical application. Epigenetics is considered by many to be the new genetics in that many biological phenomena are controlled, not through gene mutations, but rather through reversible and heritable epigenetic processes. These epigenetic processes range from DNA methylation to prions. The biological processes impacted by epigenetics are vast and encompass effects in lower organisms and humans that include tissue and organ regeneration, X-chromosome inactivation, stem cell differentiation, genomic imprinting, and aging. The first edition of this important work received excellent reviews; the second edition continues its comprehensive coverage adding more current research and new topics based on customer and reader reviews, including new discoveries, approved therapeutics, and clinical trials. From molecular mechanisms and epigenetic technology, to discoveries in human disease and clinical epigenetics, the nature and applications of the science is presented for those with interests ranging from the fundamental basis of epigenetics, to therapeutic interventions for epigenetic-based disorders. Timely and comprehensive collection of fully up-to-date reviews on epigenetics that are organized into one volume and written by leading figures in the field Covers the latest advances in many different areas of epigenetics, ranging from basic aspects, to technologies, to clinical medicine Written at a verbal and technical level that can be understood by scientists and college students Updated to include new epigenetic discoveries, newly approved therapeutics, and clinical trials

Epigenetics and Human Health

Epigenetics and Human Health Book
Author : Alexander Haslberger,Sabine Greßler
Publisher : John Wiley & Sons
Release : 2011-08-24
ISBN : 352764475X
Language : En, Es, Fr & De

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Book Description :

After first introducing the concept of epigenetics, this handbook and ready reference provides an overview of the main research on epigenetics. It adopts a multidisciplinary approach, involving molecular biology, molecular epidemiology and nutritional science, with a special focus of the book is on disease prevention and treatment. Of interest to all healthcare-related professionals as well as nutritionists, and the medical community focusing on disease prevention.

Obesity Smoking and Fatty Liver Disease

Obesity  Smoking  and Fatty Liver Disease Book
Author : Amiya P. Sinha-Hikim,Sushil K. Mahata
Publisher : Frontiers Media SA
Release : 2018-04-20
ISBN : 2889454738
Language : En, Es, Fr & De

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Book Description :

The World Health Organization Organization estimates that over 1.9 billion people worldwide are now obese or overweight [body mass index (BMI) > 27 Kg/m2]. Type 2 diabetes (T2D) is now recognized as the most devastating complications of obesity. Intimate relationship exists between obesity, innate (neutrophils, dendritic cells, macrophages, mast cells, and eosinophils) and adaptive (B and T lymphocytes) immune cells. Cells of the innate immune system produce inflammatory cytokines, and other factors leading to impaired insulin secretion and insulin resistance. Likewise, B lymphocytes (mostly B2 cells) are activated in obese adipose tissue and contribute to proinflammatory activation of adipose tissue macrophages and T cells resulting in insulin resistance. Thus, obesity-induced low-grade inflammation in adipose tissue, liver, skeletal muscle, and pancreas not only activates the innate and adaptive systems affecting metabolic homeostasis, it also results in fibrosis and necrosis. It is now becoming increasingly evident that fibrosis is a major contributor to metabolic dysregulation in obese and T2D patients and that advanced liver fibrosis leads to cirrhosis and death. The health risks associated with obesity are further exaggerated by smoking. This research topic consisting of 10 articles (9 reviews and one original) provide a comprehensive assessment of the impact of obesity on immunometabolism, cardiac functions, the connections of nicotine to NAFLD, the expression of hepatic carcinoembryonic antigen related cell adhesion molecule 1 (CEACAM1), the role chromogranin A (CgA) and its peptides pancreastatin (PST) and catestatin (CST) in insulin sensitivity, the loss of skeletal muscle mass and function, and the alternate RNA splicing.

Nutrition Epigenetic Mechanisms and Human Disease

Nutrition  Epigenetic Mechanisms  and Human Disease Book
Author : Nilanjana Maulik,Gautam Maulik
Publisher : CRC Press
Release : 2010-12-03
ISBN : 1439804826
Language : En, Es, Fr & De

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Book Description :

As nutrition research is shifting its focus from epidemiology and physiology to effects of nutrients at the molecular level, a uniquely tailored diet that corresponds to the demands of our genetic signature is emerging as an indispensable need. Using high-throughput genomic tools, nutrigenomics unravels the influence of micro- and macronutrients as

Pediatric Primary Care E Book

Pediatric Primary Care   E Book Book
Author : Catherine E. Burns,Ardys M. Dunn,Margaret A. Brady,Nancy Barber Starr,Catherine G. Blosser,Dawn Lee Garzon Maaks
Publisher : Elsevier Health Sciences
Release : 2012-03-01
ISBN : 1455742171
Language : En, Es, Fr & De

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Book Description :

Covering the full spectrum of health conditions seen in the primary care of children, Pediatric Primary Care, 5th Edition emphasizes both prevention and management from the unique perspective of the Nurse Practitioner. Written by an expert editor/contributor team, it provides in-depth, evidence-based guidance for assessing and managing health problems in children from infancy through adolescence. Other key topics include developmental theory, the health status of children today, issues of daily living, and cultural considerations. Four-part organization includes an introductory unit, plus units on child development, the health management of children, and diseases and disorders common to childhood. UNIQUE! Functional health patterns framework in Unit Three provides a lens for discussing health promotion through the various components of healthy living. UNIQUE! ICD framework in Unit Four addresses the classification used to code diseases in both hospital and outpatient settings. UNIQUE! Practice management chapter provides need-to-know information on managing a private healthcare practice, including issues of productivity, compliance with applicable laws, quality-of-care indicators, and successful business practices. UNIQUE! Environmental health chapter offers evidence-based content on the effects of environmental toxicants, such as tobacco smoke, heavy metals, and air pollutants. An 8-page color insert presents over 40 photos that visually demonstrate key assessment findings for ear, skin, and other conditions. NEW! Pediatric Pain Management chapter addresses the increased recognition of pain as the "fifth vital sign" with expanded coverage of acute and chronic pain management in children. Extensively revised and updated genetics chapter presents a new paradigm for addressing genetic considerations in clinical practice, including an introduction to epigenetics. Increased emphasis on health disparities explores the growing health disparities among children in the U.S and worldwide and provides strategies to help patients and parents gain accessibility to health care resources. NEW! Content on implementing a "medical home" explores the trend toward family-centered coordinated health care and fosters appropriate treatment for children with chronic disease. NEW! Updated coverage takes a more global approach, exploring the health status of children outside the U.S. Expanded imaging content offers valuable guidance on using various imaging modalities, including how to prepare the child for diagnostics.

Molecular Pathology

Molecular Pathology Book
Author : William B. Coleman,Gregory J. Tsongalis
Publisher : Academic Press
Release : 2009-03-10
ISBN : 9780123859129
Language : En, Es, Fr & De

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Book Description :

Molecular Pathology: The Molecular Basis of Human Disease provides a current and comprehensive view of the molecular basis and mechanisms of human disease. Combining accepted principles with broader theoretical concepts and with contributions from a group of experts, the book looks into disease processes in the context of traditional pathology and their implications for translational molecular medicine. It also discusses concepts in molecular biology and genetics, recent scientific and technological advances in modern pathology, the concept of ""molecular pathogenesis"" of disease, and how disease evolves from normal cells and tissues due to perturbations in molecular pathways. The book describes the integration of molecular and cellular pathogenesis using a bioinformatics approach and a systems biology approach to disease pathogenesis. It also discusses current and future strategies in molecular diagnosis of human disease, and the impact of molecular diagnosis on treatment decisions and the practice of personalized medicine. This book is a valuable resource for students, biomedical researchers, practicing physician-scientists who undertake disease-related basic science and translational research, and pathology residents and other postdoctoral fellows. * Exam Master® web site will host "Self-assessment" questions that students can use to study for the molecular section of the board exam * Companion Web Site – will host a complete set of PowerPoint slides: to include images from the book and additional images for teaching; course materials; lecture materials * Teaches from the perspective of “integrative systems biology, which encompasses the intersection of all molecular aspects of biology, as applied to understanding human disease * Outlines the principles and practice of molecular pathology * Explains the practice of “molecular medicine and the translational aspects of molecular pathology

Pathophysiology

Pathophysiology Book
Author : Matthew Sorenson,Lauretta Quinn,Diane Klein
Publisher : Pearson
Release : 2018-01-03
ISBN : 9780133414783
Language : En, Es, Fr & De

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Book Description :

For courses in pathophysiology. A human approach to pathophysiology, with an eye on promoting health Pathophysiology: Concepts of Human Disease focuses on the human aspect of pathophysiology, acknowledging that diseases, disorders, and syndromes occur not in a vacuum, but in people - across the lifespan. Drawing on the health stories of real individuals, the authors provide the latest information in pathophysiology that is relevant to clinical practice, while empowering students with competencies that endure throughout a nursing career. Throughout the text, the approach to pathophysiology reflects a shift of focus in healthcare from understanding diseases in their later stages to understanding risk factors and the interventions that can maintain good health and slow progression of disease in humans. Also available with MyLab Nursing MyLab(tm) is the teaching and learning platform that empowers you to reach every student. By combining trusted author content with digital tools and a flexible platform, MyLab personalizes the learning experience and improves results for each student. MyLab Nursing helps students master key concepts, prepare for success on the NCLEX-RN® exam, and develop clinical reasoning skills. Note: You are purchasing a standalone product; MyLab Nursing does not come packaged with this content. Students, if interested in purchasing this title with MyLab Nursing, ask your instructor to confirm the correct package ISBN and Course ID. Instructors, contact your Pearson representative for more information. If you would like to purchase both the physical text and MyLab Nursing, search for: 013487434X / 978013487434 0 Pathophysiology: Concepts of Human Disease Plus MyNursingLab -- Access Card Package, 1/e Package consists of: 0133414787 / 9780133414783 Pathophysiology: Concepts of Human Disease, 1/e 0134746783 / 9780134746784 MyNursingLab with Pearson eText 2.0 - Access Card - for Pathophysiology, 1/e

Genetics for Health Professionals in Cancer Care

Genetics for Health Professionals in Cancer Care Book
Author : Chris Jacobs,Lorraine Robinson,Patricia Webb
Publisher : OUP Oxford
Release : 2014-08-14
ISBN : 0191653497
Language : En, Es, Fr & De

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Book Description :

The role of genetics is becoming increasingly important in all aspects of healthcare and particularly in the field of cancer care. Genetics for Health Professionals in Cancer Care: From Principles to Practice equips health professionals with the knowledge and skills required for all aspects of managing cancer family history. This includes taking an accurate cancer family history and drawing a family tree; understanding cancer biology, basic cancer genetics and the genes involved in hereditary breast, ovarian, prostate, colorectal, gastric and related gynaecological cancers and rare cancer predisposing syndromes; assessing cancer risk and communicating risk information; early detection and risk reducing measures available for those at increased risk and managing individuals with hereditary cancer. Drawing on experiences of health professionals, Genetics for Health Professionals in Cancer Care discusses the challenges raised and provides practical advice and insight into what happens when a patient is referred for genetic counselling and genetic testing, including the psychological, social and ethical issues faced by individuals and families with and at risk of hereditary cancer. The book also provides practical guidance on setting up a cancer family history clinic in primary and secondary care. Genetics for Health Professionals in Cancer Care is essential reading for healthcare professionals working with cancer patients and their families, and is an ideal reference text for non-specialists working in cancer genetics.

Epigenetic Regulation and Epigenomics

Epigenetic Regulation and Epigenomics Book
Author : Robert A. Meyers
Publisher : John Wiley & Sons
Release : 2012-10-02
ISBN : 3527668624
Language : En, Es, Fr & De

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Book Description :

Epigenetics is a term in biology referring to heritable traits that do not involve changes in the underlying DNA sequence of the organism. Epigenetic traits exist on top of or in addition to the traditional molecular basis for inheritance. The "epigenome" is a parallel to the word "genome," and refers to the overall epigenetic state of a cell. Cancer and stem cell research have gradually focused attention on these genome modifications. The molecular basis of epigenetics involves modifications to DNA and the chromatin proteins that associate with it. Methylation, for example, can silence a nearby gene and seems to be involved in some cancers. Epigenetics is beginning to form and take shape as a new scientific discipline, which will have a major impact on Medicine and essentially all fields of biology. Increasingly, researchers are unearthing links between epigenetics and a number of diseases. Although in recent years cancer has been the main focus of epigenetics, recent data suggests that epigenetic plays a critical role in psychology and psychopathology. It is being realized that normal behaviors such as maternal care and pathologies such as Schizophrenia and Alzheimer's might have an epigenetic basis. It is also becoming clear that nutrition and life experiences have epigenetic consequences. Discover more online content in the Encyclopedia of Molecular Cell Biology and Molecular Medicine.

Junk DNA

Junk DNA Book
Author : Nessa Carey
Publisher : Icon Books
Release : 2015-03-05
ISBN : 184831826X
Language : En, Es, Fr & De

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Book Description :

From the author of the acclaimed The Epigenetics Revolution (‘A book that would have had Darwin swooning’ – Guardian) comes another thrilling exploration of the cutting edge of human science. For decades after the structure of DNA was identified, scientists focused purely on genes, the regions of the genome that contain codes for the production of proteins. Other regions – 98% of the human genome – were dismissed as ‘junk’. But in recent years researchers have discovered that variations in this ‘junk’ DNA underlie many previously intractable diseases, and they can now generate new approaches to tackling them. Nessa Carey explores, for the first time for a general audience, the incredible story behind a controversy that has generated unusually vituperative public exchanges between scientists. She shows how junk DNA plays an important role in areas as diverse as genetic diseases, viral infections, sex determination in mammals, human biological complexity, disease treatments, even evolution itself – and reveals how we are only now truly unlocking its secrets, more than half a century after Crick and Watson won their Nobel prize for the discovery of the structure of DNA in 1962.

Biological Sciences Review Magazine Volume 31 2018 19 Issue 2

Biological Sciences Review Magazine Volume 31  2018 19 Issue 2 Book
Author : Philip Allan Magazines
Publisher : Hachette UK
Release : 2018-11-26
ISBN : 1510459472
Language : En, Es, Fr & De

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Book Description :

This A-level magazine makes cutting-edge biology research accessible and relevant for students, supporting them to get their best grade. Featuring the latest thinking on advanced topics, Biological Sciences Review aims to challenge students and increase their confidence with data, technical terms, practical experiments and exam skills. Contents HIV: knowledge is power Michael McKenna Bioethics Inside the killing jar: why entomologists kill insects Adam Hart Making a muscle Teresa Audesirk Antibody protein structure Martin Rowland The genome remixed: epigenetics and human disease Paul Shiels, Laura Monaghan and Ognian Neytchev Banana blight Liz Sheffield and Kevin O'Dell Spotlight The curious biology of the naked mole-rat Chris Faulkes Upgrade Testing practical skills Martin Rowland Congenital heart disease Donna Page Prospects Technical paths into a world of research Lisa Jameson What is...? Immunology Phoebe Sharp Images of biology Collagen connections Marion Leibl

Epigenetics

Epigenetics Book
Author : Lyle Armstrong
Publisher : Garland Science
Release : 2013-11-20
ISBN : 1317683153
Language : En, Es, Fr & De

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Book Description :

The concept of epigenetics has been known about since the 1940s, but it is only in the last 10 years that research has shown just how wide ranging its effects are. It is now a very widely-used term, but there is still a lot of confusion surrounding what it actually is and does. Epigenetics is a new textbook that brings together the structure and machinery of epigenetic modification, how epigenetic modification controls cellular functions, and the evidence for the relationship between epigenetics and disease. It is a valuable source of information about all aspects of the subject for undergraduate students, graduate students, and professionals.

Human Genetics

Human Genetics Book
Author : Anne Gardner,Teresa Davies
Publisher : Scion Pub Limited
Release : 2009
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

This book covers basic human genetics, details the techniques available for disease diagnosis and how these are used in the lab, before concluding with information on prenatal diagnosis, genetic counselling and ethics. This is the ideal handbook for biomedical science students and anyone working in a diagnostic genetics lab.

Dermatology E Book

Dermatology E Book Book
Author : Jean L. Bolognia,Joseph L. Jorizzo,Julie V. Schaffer
Publisher : Elsevier Health Sciences
Release : 2012-06-08
ISBN : 0702051829
Language : En, Es, Fr & De

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Book Description :

Dermatology, edited by world authorities Jean L. Bolognia, MD, Joseph L. Jorizzo, MD, and Julie V. Schaffer, MD, is an all-encompassing medical reference book that puts the latest practices in dermatologic diagnosis and treatment at your fingertips. It delivers more comprehensive coverage of basic science, clinical practice, pediatric dermatology, and dermatologic surgery than you’ll find in any other source. Whether you’re a resident or an experienced practitioner, you’ll have the in-depth, expert, up-to-the-minute answers you need to overcome any challenge you face in practice. Find answers fast with a highly user-friendly, "easy-in-easy-out" format and a wealth of tables and algorithms for instant visual comprehension. Get full exposure to core knowledge with coverage of dermatology’s entire spectrum of subspecialties. See just the essential information with "need-to-know" basic science information and key references. Expedite decision making and clarify complex concepts with logical tables, digestible artwork, and easy-to-grasp schematics. Visualize more of the conditions you see in practice with over 3500 illustrations, of which over 1,400 are new: 1,039 clinical images, 398 pathology slides, and 152 schematics. Stay at the forefront of your field with updated treatment methods throughout, as well as an increased focus on patients with skin of color. Get an enhanced understanding of the foundations of dermatology in pathology, the clinical setting, and dermoscopy with a completely rewritten introductory chapter. Better comprehend the clinical-pathological relationship of skin disease with increased histologic coverage. Bolognia’s Dermatology is the ultimate multimedia reference for residents in training AND the experienced practitioner.

Pharmacogenomics An Introduction and Clinical Perspective

Pharmacogenomics An Introduction and Clinical Perspective Book
Author : Joseph S. Bertino,Angela Kashuba,Joseph D. Ma,C. Lindsay DeVane,Uwe Fuhr
Publisher : McGraw Hill Professional
Release : 2012-10-09
ISBN : 0071741690
Language : En, Es, Fr & De

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Book Description :

Pharmacogenomics is comprehensive textbook detailing how genetic makeup affects a body's response to drugs.

Molecular Biology of RNA

Molecular Biology of RNA Book
Author : David Elliott,Michael Ladomery
Publisher : Oxford University Press
Release : 2015-11-12
ISBN : 0199671397
Language : En, Es, Fr & De

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Book Description :

RNA plays a central, and until recently, somewhat underestimated role in the genetics underlying all forms of life on earth. This versatile molecule not only plays a crucial part in the synthesis of proteins from a DNA template, but is also intrinsically involved in the regulation of gene expression, and in catalysis.This landmark text provides a systematic overview of the exciting and rapidly moving field of RNA biology. For the secondedition of Molecular Biology of RNA more introductory material has been incorporated at the beginning of the text, while new material has been included throughout - particularly in relation to RNA bindingdomains, non-coding RNAs, and the connection between RNA biology and epigenetics. Finally, a new closing chapter discusses how exciting new technologies are being used to explore current topical areas of research.