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Epigenetics And Dermatology

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Epigenetics and Dermatology

Epigenetics and Dermatology Book
Author : Qianjin Lu,Christopher C. Chang,Bruce C. Richardson
Publisher : Academic Press
Release : 2015-02-16
ISBN : 0128012722
Language : En, Es, Fr & De

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Book Description :

Epigenetics and Dermatology explores the role of epigenetics in the pathogenesis of autoimmune-related skin diseases and skin cancer. Leading contributors cover common and uncommon skin conditions in which extensive epigenetic research has been done. They explain how environmental exposures (chemicals, drugs, sunlight, diet, stress, smoking, infection, etc.) in all stages of life (from a fetus in-utero to an elderly person) may result in epigenetic changes that lead to development of some skin diseases in life. They also discuss the possibilities of new and emergent epigenetic treatments which are gradually being adopted in management of various skin diseases. Chapters follow a conventional structure, covering fundamental biology of the disease condition, etiology and pathogenesis, diagnosis, commonly available treatments, and epigenetic therapy where applicable. Discusses the basic biology of skin diseases and skin cancers induced or aggravated by aberrant epigenetic changes Evaluates how to approach autoimmune-related skin diseases from a therapeutic perspective using the wealth of emergent epigenetic clinical trials Offers a coherent and structured table of contents with basic epigenetic biology followed by discussion of the spectrum of rheumatologic through neoplastic skin diseases, finally ending with a discourse on epigenetic therapy

Epigenetic Regulation of Skin Development and Regeneration

Epigenetic Regulation of Skin Development and Regeneration Book
Author : Vladimir A. Botchkarev,Sarah E. Millar
Publisher : Springer
Release : 2018-09-03
ISBN : 3319167693
Language : En, Es, Fr & De

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Book Description :

This indispensable volume highlights recent studies identifying epigenetic mechanisms as essential regulators of skin development, stem cell activity and regeneration. Chapters are contributed by leading experts and promote the skin as an accessible model system for studying mechanisms that control organ development and regeneration. The timely discussions contained throughout are of broad relevance to other areas of biology and medicine and can help inform the development of novel therapeutics for skin disorders as well as new approaches to skin regeneration that target the epigenome. Part of the highly successful Stem Cells and Regenerative Medicine series, Epigenetic Regulation of Skin Development and Regeneration uncovers the fundamental significance of epigenetic mechanisms in skin development and regeneration, and emphasizes the development of new therapies for a number of skin disorders, such as pathological conditions of epidermal differentiation, pigmentation and carcinogenesis. At least six categories of researchers will find this book essential, including stem cell, developmental, hair follicle or molecular biologists, and gerontologists or clinical dermatologists.

Personalized Evolutionary and Ecological Dermatology

Personalized  Evolutionary  and Ecological Dermatology Book
Author : Robert A. Norman
Publisher : Springer
Release : 2016-09-21
ISBN : 3319410881
Language : En, Es, Fr & De

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Book Description :

This book discusses the exciting potential for dermatology to embrace developments to enhance the profession’s valuable pattern recognition, diagnostic, and treatment skills. Personalized medicine (PM) and genomics are easily accessible and enable the customization of healthcare using molecular analysis to influence medical decisions, practices, and therapies for the individual patient. The evolution of the skin, and the manner in which dermatological conditions are described and managed, reveals the need to consider many aspects on a personal level. New research data are based on the use of evolutionary medicine and genomics to highlight how we can become more successful at finding the most efficacious types of antibiotic or therapy and dosage for a particular disease or pathogen and build a competitive edge by prevention and risk management against invasive viruses, bacteria, or wrongly administered drugs. As more is understood about what grows on us and how it all interacts, along with how the introduction of new antibiotics, biologics, and other therapies affect our skin’s ecological balance, this book aims to create a heightened sense of the importance and offerings of ecological dermatology.

Mosaicism in Human Skin

Mosaicism in Human Skin Book
Author : Rudolf Happle
Publisher : Springer Science & Business Media
Release : 2013-11-26
ISBN : 3642387659
Language : En, Es, Fr & De

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Book Description :

Mosaicism is a powerful biologic concept, originally developed from studying plants and animals. All cutaneous neoplasms, both benign and malignant, reflect mosaicism, which is the necessary basis to explain numerous human skin disorders. For example, various mosaic patterns visualize the embryonic development of human skin and X-linked skin disorders explain why women live longer than men, and so on. This book presents, for the first time, a comprehensive overview on the strikingly manifold patterns and peculiarities of mosaic skin disorders. This reader-friendly structured and straightforward publication will help the dermatologist to understand the underlying molecular mechanisms of skin disorders in order to further improve the treatment outcome.

Epigenetics in Health and Disease

Epigenetics in Health and Disease Book
Author : Igor Kovalchuk,Olga Kovalchuk
Publisher : FT Press
Release : 2012
ISBN : 013259708X
Language : En, Es, Fr & De

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Book Description :

"After reviewing the field's history and context, the authors introduce and explain each key epigenetic mechanism. Next, they extensively discuss the roles these mechanisms may play in inheritance, development, health and disease, behavior, evolution, ecology, and the interactions of individual organisms with their environments"--Cover, p. [4].

Human Skin Cancers

Human Skin Cancers Book
Author : Miroslav Blumenberg
Publisher : BoD – Books on Demand
Release : 2018-05-02
ISBN : 1789230942
Language : En, Es, Fr & De

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Book Description :

Human skin cancers, the most common type of tumors, represent a significant health burden. The deadliest is unquestionably melanoma. Half of melanomas have an activating mutation in the BRAF gene, prompting development of novel drugs, vemurafenib and dabrafenib, specifically targeting mutated BRAF. Trametinib and cobimetinib, which block MEK, a BRAF effector protein, have been used in combination with BRAF inhibitors. A promising new melanoma treatment is immunotherapy, approach that boosts patient's own immune system to attack cancer. Pembrolizumab and nivolumab inhibit PD-1, whereas Ipilimumab targets CTLA-4, another immunity check point, to boost the immune response. Here we focus on pathways, mechanisms, targets and treatments of human skin cancers, with particular emphasis on the new developments in the research on melanomas.

Translational Systems Medicine and Oral Disease

Translational Systems Medicine and Oral Disease Book
Author : Stephen Sonis,Alessandro Villa
Publisher : Academic Press
Release : 2019-09-14
ISBN : 0128137630
Language : En, Es, Fr & De

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Book Description :

Translational Systems Medicine and Oral Disease bridges the gap between discovery science and clinical oral medicine, providing opportunities for both the scientific and clinical communities to understand how to apply recent findings in cell biology, genomic profiling, and systems medicine to favorably impact the diagnosis, treatment and management of oral diseases. Fully illustrated chapters from leading international contributors explore clinical applications of genomics, proteomics, metabolomics, microbiomics and epigenetics, as well as analytic methods and functional omics in oral medicine. Disease specific chapters detail systems approaches to periodontal disease, salivary gland diseases, oral cancer, bone disease, and autoimmune disease, among others. In addition, the book emphasizes biological synergisms across disciplines and their translational impact for clinicians, researchers and students in the fields of dentistry, dermatology, gastroenterology, otolaryngology, oncology and primary care. Presents the work of leading international researchers and clinicians who speak on the clinical applications of genomics, proteomics, metabolomics, microbiomics, and epigenetics, as well as analytic methods and functional omics in oral medicine Provides full-color, richly illustrated chapters that examine systems approaches to periodontal disease, salivary gland diseases, oral cancer, bone disease and autoimmune diseases Includes clinical case studies that illustrate examples of oral disease diagnostics and management, highlighting points of key importance for the reader Emphasizes biological synergisms across disciplines and their translational impact for clinicians, researchers, and students in the fields of dentistry, dermatology, gastroenterology, otolaryngology, oncology, and primary care

Epigenetics and Regeneration

Epigenetics and Regeneration Book
Author : Anonim
Publisher : Academic Press
Release : 2019-05-24
ISBN : 0128148802
Language : En, Es, Fr & De

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Book Description :

Epigenetics and Regeneration compiles the first foundational reference on epigenetic mechanisms governing tissue development, repair, homeostasis, and regeneration, as well as pathways to employ these mechanisms in clinical practice and translational science. In this book, life science researchers, clinicians, and students will discover an interdisciplinary resource bringing together common themes in the field, background overviews, research methods, recent advances, and opportunities for drug discovery. Throughout this volume, special attention is paid to pre-clinical and first clinical studies aimed at increasing the regenerative potential of damaged tissues by epigenetic drugs, as well as innovative, discipline spanning strategies to enhance cell reprogramming. As an all-inclusive, evidence-based volume, Epigenetics and Regeneration will stimulate discussion and boost new research in this fascinating and impactful area of translational epigenetics. Provides a foundational overview of epigenetics in regenerative medicine Examines epigenetic components of tissue regeneration for a variety of organ systems and tissue types, as well as current attempts to employ these mechanisms in clinical practice Offers researchers, students, clinicians, and pharmacologists the tools they need to enhance tissue development, repair, homeostasis, and regeneration and explore new epigenetic therapeutic pathways Features chapter contributions from leading international researchers and clinicians in the fields of epigenetics and regenerative medicine

Epigenetics in Allergy and Autoimmunity

Epigenetics in Allergy and Autoimmunity Book
Author : Christopher Chang,Qianjin Lu
Publisher : Springer Nature
Release : 2020-05-22
ISBN : 9811534497
Language : En, Es, Fr & De

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Book Description :

This book will address the growing roles of epigenetics in disease pathogenesis, and review the contribution of epigenetic modifications to disease onset and progression. The roles that epigenetics plays in facilitating effects of the environment on allergy and immunologic diseases will be reviewed. The book is divided into three parts – the first is an introduction to epigenetics and the methods that have been developed to study epigenetics, the second addresses epigenetics in allergic diseases and the third part will cover epigenetics in autoimmune diseases. With the rapid expansion of knowledge of how genes are regulated and how this regulation affects disease phenotypes, this book will be attractive to experienced researchers as well as those just launching an epigenetics research program. It will also be of interest to allergist, immunologists, rheumatologists and dermatologist who are engaged in clinical practice as a resource for understanding the basis for personalized and precision medicine. For example, the role that epigenetics plays in the pathogenesis in various allergic and autoimmune disorders and how this determines disease phenotypes will be covered extensively in this book. This book will thus help fill the gap in available resources on epigenetics in allergy and autoimmune diseases.

Epigenetics and Reproductive Health

Epigenetics and Reproductive Health Book
Author : Anonim
Publisher : Academic Press
Release : 2020-09-12
ISBN : 0128197544
Language : En, Es, Fr & De

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Book Description :

Epigenetics and Reproductive Health, a new volume in the Translational Epigenetics series, provides a thorough overview and discussion of epigenetics in reproduction and implications for reproductive medicine. Twenty international researchers discuss epigenetic mechanisms operating during the formation of male and female gametes, fertilization and subsequent embryo and placental development, particularly in mammals and transgenerational epigenetic inheritance. This volume also addresses aberrant epigenetic changes influencing male and female infertility, pregnancy related disorders, and those potentially linked to therapeutic manipulations and assisted reproductive technologies. Emphasis is placed on identifying biomarkers for early detection of aberrant epigenetic mechanisms. Later chapters examine the possibility of correcting these epigenetic dysfunctions, as well as current challenges and next steps in research, enabling new translational discoveries and efforts towards developing therapeutics. Thoroughly examines the influence of aberrant epigenetics during gametogenesis and embryogenesis, affecting parents, gametes and embryos, offspring and future generations Explores health outcomes for reproductive senescence, endocrine disruption, testicular cancer, prostrate cancer, breast cancer, ovarian, cancer, endometrial cancer and cervical cancers Features chapter contributions from international researchers in the field

Skin Diseases New Insights for the Healthcare Professional 2013 Edition

Skin Diseases  New Insights for the Healthcare Professional  2013 Edition Book
Author : Anonim
Publisher : ScholarlyEditions
Release : 2013-07-22
ISBN : 148165585X
Language : En, Es, Fr & De

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Book Description :

Skin Diseases: New Insights for the Healthcare Professional: 2013 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Additional Research in a concise format. The editors have built Skin Diseases: New Insights for the Healthcare Professional: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Additional Research in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Skin Diseases: New Insights for the Healthcare Professional: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Cultural Practices and Dermatoses

Cultural Practices and Dermatoses Book
Author : Neelam A. Vashi
Publisher : Springer Nature
Release : 2021-04-28
ISBN : 3030689921
Language : En, Es, Fr & De

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Book Description :

This book addresses the importance of the physicians’ understanding on how varying ethnic and cultural identities can affect dermatological disease presentation in patients. It bridges the gap in knowledge for practicing dermatologists, especially those not studying or practicing in a highly multi-ethnic center who may not be exposed to patients from a variety of cultures. Concise and cohesive, the book examines how dermatoses can manifest due to cosmetic practices, therapeutics, religious practices, cultural hair-related practices, and environmental variables. These elements underscore that without exposure to patients of varying backgrounds, it can be nearly impossible to learn about practices that may influence a patient's health. There are many examples of cultural practices causing dermatologic lesions, and it is becoming increasingly more likely that practicing dermatologists will encounter patients with these findings as migration, tourism, and public interest continue to rise. Socially conscientious and relevant, Cultural Practices and Dermatoses covers everything from more common cultural practices, such as acupuncture and threading, to lesser known ones, like pew blisters and turban ear, as there is limited medical literature describing their cutaneous effects and complications.

Epigenetics Nuclear Organization Gene Function

Epigenetics  Nuclear Organization   Gene Function Book
Author : John C. Lucchesi
Publisher : Oxford University Press
Release : 2018-12-19
ISBN : 0192567160
Language : En, Es, Fr & De

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Book Description :

Epigenetics is the study of heritable changes in gene function that do not involve changes in the DNA sequence. These changes, consisting principally of DNA methylation, histone modifications, and non-coding RNAs, maintain or modulate the initial impact of regulatory factors that recognize and associate with particular genomic sequences. Epigenetic modifications are manifest in all aspects of normal cellular differentiation and function, but they can also have damaging effects that result in pathologies such as cancer. Research is continuously uncovering the role of epigenetics in a variety of human disorders, providing new avenues for therapeutic interventions and advances in regenerative medicine. This book's primary goal is to establish a framework that can be used to understand the basis of epigenetic regulation and to appreciate both its derivation from genetics and interdependence with genetic mechanisms. A further aim is to highlight the role played by the three-dimensional organization of the genetic material itself (the complex of DNA, histones and non-histone proteins referred to as chromatin), and its distribution within a functionally compartmentalized nucleus. This architectural organization of the genome plays a major role in the subsequent retrieval, interpretation, and execution of both genetic and epigenetic information.

Introductory Review on Sirtuins in Biology Aging and Disease

Introductory Review on Sirtuins in Biology  Aging  and Disease Book
Author : Leonard Guarente,Raul Mostoslavsky,Aleksey Kazantsev
Publisher : Academic Press
Release : 2018-04-20
ISBN : 012813500X
Language : En, Es, Fr & De

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Book Description :

Introductory Review on Sirtuins in Biology and Disease provides key insights for scientists and advanced students who need to understand sirtuins and the current research in this field. This book is ideal for pharmaceutical companies as they develop novel targets using sirtuins for metabolic diseases, cancer and neurodegenerative illnesses. Sirtuins are a diverse family of proteins, with several members in mammals. The functional diversity of sirtuins is rather broad, and they have been implicated in various central biological processes. Thus, they are also highly relevant in the context of various human diseases, from cancer to neurodegeneration. Covers both the general and specific aspects of sirtuin proteins and their role in biology, aging and disease Presents a top quality collection of leading experts who contribute on a wide range of sirtuin-related topics Ideal resource for pharmaceutical companies as they develop novel targets using sirtuins for metabolic diseases, cancer and neurodegenerative illnesses

Medical Epigenetics

Medical Epigenetics Book
Author : Trygve Tollefsbol
Publisher : Academic Press
Release : 2016-06-21
ISBN : 0128032405
Language : En, Es, Fr & De

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Book Description :

Medical Epigenetics provides a comprehensive analysis of the importance of epigenetics to health management. The purpose of this book is to fill a current need for a comprehensive volume on the medical aspects of epigenetics with a focus on human systems, epigenetic diseases that affect these systems and modes of treating epigenetic-based disorders and diseases. The intent of this book is to provide a stand-alone comprehensive volume that will cover all human systems relevant to epigenetic maladies and all major aspects of medical epigenetics. The overall goal is to provide the leading book on medical epigenetics that will be useful not only to physicians, nurses, medical students and many others directly involved with health care, but also investigators in life sciences, biotech companies, graduate students and many others who are interested in more applied aspects of epigenetics. Research in the area of translational epigenetics is a cornerstone of this volume. Critical reviews dedicated to the burgeoning role of epigenetics in medical practice Coverage of emerging topics including twin epigenetics as well as epigenetics of gastrointestinal disease, muscle disorders, endocrine disorders, ocular medicine, pediatric diseases, sports medicine, noncoding RNA therapeutics, pain management and regenerative medicine Encompasses a disease-oriented perspective of medical epigenetics as well as diagnostic and prognostic epigenetic approaches to applied medicine

Harper s Textbook of Pediatric Dermatology

Harper s Textbook of Pediatric Dermatology Book
Author : Peter H. Hoeger,Veronica Kinsler,Albert C. Yan,Christine Bodemer,Margarita Larralde,David Luk,Vibhu Mendiratta,Diana Purvis
Publisher : John Wiley & Sons
Release : 2019-12-04
ISBN : 1119142806
Language : En, Es, Fr & De

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Book Description :

A consummate classic with a fresh approach to pediatric dermatology Children ́s skin is different. Maturation affects the epidermal barrier, the cutaneous microbiome, adnexal structures, vasculature, and transcutaneous absorption of drugs. The immature skin is more susceptible to pathogens and environmental disruption. Many genetic disorders are either present at birth or manifest early in childhood. Skin diseases thus present differently in children than in adults. Pediatric dermatology has seen significant advances over the last decade, particularly in the field of molecular genetics research, which has furthered our understanding of the pathogenesis of many skin diseases and the development of new approaches to treatment. This fourth edition of the Harper classic provides state-of-the-art information on all aspects of skin disease in children. It covers the diagnosis and treatment of all conditions - both common and rare - with a consistently evidence-based approach. Existing content has been refreshed and fully updated to reflect emerging thinking and to incorporate the latest in research and clinical data - especially at the genetic level. This new fourth edition includes: Greater focus on the genetics behind skin disease, including new genes/genodermatoses, progress in genetic analysis, and stem cell transplants Increased coverage of lasers and other technologies used to treat skin disease More summary tables, learning points, tables of differential diagnosis, and clinical algorithms for diagnosis and management Additional online features, including patient information links and multiple choice questions Harper's Textbook of Pediatric Dermatology delivers crucial clinical insights and up-to-date research information that spans the breadth of the field. As the most comprehensive reference book on this subject available, this revised fourth edition will support and guide the daily practice of both dermatologists and pediatricians across the world.

Medical Epigenetics

Medical Epigenetics Book
Author : Anonim
Publisher : Academic Press
Release : 2021-08-27
ISBN : 0128243260
Language : En, Es, Fr & De

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Book Description :

Medical Epigenetics, Second Edition provides a comprehensive analysis of epigenetics in health management, across a broad spectrum of disease categories and specialties, and with a focus on human systems, epigenetic diseases that affect these systems, and evolving modes of epigenetic-based treatment. Here, more than 40 leading researchers examine how each human system is affected by epigenetic maladies, offering an all-in-one resource on medical epigenetics not only for those directly involved with health care, but investigators in life sciences, biotech companies, graduate students, and others who are interested in applied aspects of epigenetics. Incorporating both diagnostic and prognostic epigenetic approaches, this volume also fully supports the application of epigenetics in precision medicine. This second edition of Medical Epigenetics, a volume in the Translational Epigenetics series, has been fully revised to address recent advances in disease epigenetics and role of epigenetics in precision medicine, with all-new chapters on skin cancer epigenetics, network analysis in medical epigenetics, machine learning in epigenetic diseases, and clinical trials of epigenetics drugs. Features chapters from leading researchers and clinicians dedicated to the burgeoning role of epigenetics in medical practice Covers emerging topics, including twin epigenetics, as well as epigenetics of gastrointestinal disease, muscle disorders, endocrine disorders, ocular medicine, pediatric diseases, sports medicine, noncoding RNA therapeutics, pain management and regenerative medicine Organized from system disorders to multi-system disorders that involve epigenetic aberrations Examines the role of epigenetics in precision medicine

Molecular Dermatology

Molecular Dermatology Book
Author : ​Natalia V. Botchkareva,Gillian E. Westgate
Publisher : Humana
Release : 2020-06-17
ISBN : 9781071606476
Language : En, Es, Fr & De

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Book Description :

This volume delivers the most important laboratory techniques that underlie dermatological investigation, including in situ, in vitro, ex vivo, and in vivo models of skin, its appendages (hair follicles, sebaceous and sweat glands), and immune cells. Also included are unique techniques that unravel epigenetic mechanisms in skin and hair follicle cells, such as gene organization in the nucleus and gene expression regulation by the non-coding transcriptome, which are important recent developments in investigative dermatology. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Molecular Dermatology: Methods and Protocols serves as an essential resource for researchers working in the areas of fundamental as well as applied dermatological science.

Epigenetics

Epigenetics Book
Author : Yildiz Dincer
Publisher : Unknown
Release : 2016-03-01
ISBN : 9781634844901
Language : En, Es, Fr & De

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Book Description :

Epigenetics is a relatively new field of science explaining heritable changes that are not caused by alterations in DNA sequences. Epigenetic modifications are acquired throughout life, and depend on environmental clues such as diet, lifestyle and toxin exposure. It is possible to pass down epigenetic modifications to the next generation of offspring if the modifications occur in sperm or egg cells. Additionally, epigenetic regulations are central to many cellular processes such as imprinting, X chromosome inactivation, DNA damage response, cellular reprogramming and senescence. This book provides an overview for the influence of early life nutrition on the epigenome and the role of epigenetic dysregulations in the pathogenesis of many common diseases.

Epigenetics of Aging and Longevity

Epigenetics of Aging and Longevity Book
Author : Alexey Moskalev,Alexander M. Vaiserman
Publisher : Academic Press
Release : 2017-11-17
ISBN : 012811083X
Language : En, Es, Fr & De

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Book Description :

Epigenetics of Aging and Longevity provides an in-depth analysis of the epigenetic nature of aging and the role of epigenetic factors in mediating the link between early-life experiences and life-course health and aging. Chapters from leading international contributors explore the effect of adverse conditions in early-life that may result in disrupted epigenetic pathways, as well as the potential to correct these disrupted pathways via targeted therapeutic interventions. Intergenerational epigenetic inheritance, epigenetic drug discovery, and the role of epigenetic mechanisms in regulating specific age-associated illnesses—including cancer and cardiovascular, metabolic, and neurodegenerative diseases—are explored in detail. This book will help researchers in genomic medicine, epigenetics, and biogerontology better understand the epigenetic determinants of aging and longevity, and ultimately aid in developing therapeutics to extend the human life-span and treat age-related disease. Offers a comprehensive overview of the epigenetic nature of aging, as well as the impact of epigenetic factors on longevity and regulating age-related disease Provides readers with clinical and epidemiological evidence for the role of epigenetic mechanisms in mediating the link between early-life experiences, life-course health and aging trajectory Applies current knowledge of epigenetic regulatory pathways towards developing therapeutic interventions for age-related diseases and extending the human lifespan