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Epigenetic Regulation In The Nervous System

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Epigenetic Regulation in the Nervous System

Epigenetic Regulation in the Nervous System Book
Author : J. David Sweatt,Michael J. Meaney,Eric J. Nestler,Schahram Akbarian
Publisher : Academic Press
Release : 2012-12-31
ISBN : 0123944058
Language : En, Es, Fr & De

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Book Description :

Epigenetic Regulation in the Nervous System addresses current understanding of the roles of epigenetic processes at the molecular/cellular level, their impact on neural development and behavior, and the potential roles of these mechanisms in neurological and psychiatric disorders. This award-winning volume spans molecular epigenetics, development, cellular physiology and biochemistry, synaptic and neural plasticity, and behavioral models, and is unique in covering epigenetically based disorders of the central nervous system. Behavioral epigenetics is the study of how environmental factors alter behavior, addressing the fundamental mechanisms that shape development and individual vulnerability/resilience to adverse behavioral outcomes. By understanding the molecular mechanisms involved in epigenetic modulation, researchers may be able to develop targeted therapies for those individuals in whom it malfunctions. Edited by the most highly regarded leaders in the field, this book offers a comprehensive review of behavioral epigenetics and a balanced treatment of the strengths and weaknesses in experimentation in this area. Covering background material as well as topics of current interest, it serves both as a cutting-edge resource and a foundational reference. The book will benefit neuroscience researchers and graduate students with an interest in the links between gene regulation and behavior, as will clinicians dealing with disorders such as addiction, depression, and schizophrenia. BMA Medical Book Awards 2014 - Highly Commended, Neurology, British Medical Association BMA Medical Book Awards 2014 - First Prize, Neurology, British Medical Association 2013 PROSE Award winner for Best in Reference Works and Best Single Volume Reference in Science from the Association of American Publishers Presents a unified view of epigenetic mechanisms from behavior to genes and everything in between Discusses clinically relevant disorders in the context of epigenetics research, making the volume appealing to clinicians as well as basic scientists Provides numerous practical examples for the new investigator to facilitate implementation of research in neuroepigenetics

Epigenetic Regulation in the Nervous System

Epigenetic Regulation in the Nervous System Book
Author : Morgan Bridi,Ted Abel
Publisher : Elsevier Inc. Chapters
Release : 2012-12-31
ISBN : 0128058374
Language : En, Es, Fr & De

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Book Description :

Download Epigenetic Regulation in the Nervous System book written by Morgan Bridi,Ted Abel, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Epigenetic Regulation in the Nervous System

Epigenetic Regulation in the Nervous System Book
Author : Michael J. McConnell,Fred H. Gage
Publisher : Elsevier Inc. Chapters
Release : 2012-12-31
ISBN : 0128058463
Language : En, Es, Fr & De

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Book Description :

Download Epigenetic Regulation in the Nervous System book written by Michael J. McConnell,Fred H. Gage, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Exam Prep for Epigenetic Regulation in the Nervous System

Exam Prep for  Epigenetic Regulation in the Nervous System      Book
Author : Anonim
Publisher : Unknown
Release : 2021-05-09
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

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Epigenetic Regulation in the Nervous System

Epigenetic Regulation in the Nervous System Book
Author : Jeremy J. Day,J. David Sweatt
Publisher : Elsevier Inc. Chapters
Release : 2012-12-31
ISBN : 0128058404
Language : En, Es, Fr & De

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Book Description :

Download Epigenetic Regulation in the Nervous System book written by Jeremy J. Day,J. David Sweatt, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Epigenetic Regulation in the Nervous System

Epigenetic Regulation in the Nervous System Book
Author : Michael J. Meaney,Schahram Akbarian,Eric J. Nestler,J. David Sweatt
Publisher : Elsevier Inc. Chapters
Release : 2012-12-31
ISBN : 0128058498
Language : En, Es, Fr & De

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Book Description :

Download Epigenetic Regulation in the Nervous System book written by Michael J. Meaney,Schahram Akbarian,Eric J. Nestler,J. David Sweatt, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Epigenetic Regulation in the Nervous System

Epigenetic Regulation in the Nervous System Book
Author : Tie Yuan Zhang,Christian Caldji,Josie C. Diorio,Sabine Dhir,Gustavo Turecki,Michael J. Meaney
Publisher : Elsevier Inc. Chapters
Release : 2012-12-31
ISBN : 0128058390
Language : En, Es, Fr & De

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Book Description :

Download Epigenetic Regulation in the Nervous System book written by Tie Yuan Zhang,Christian Caldji,Josie C. Diorio,Sabine Dhir,Gustavo Turecki,Michael J. Meaney, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Epigenetic Regulation in the Nervous System

Epigenetic Regulation in the Nervous System Book
Author : Alfred J. Robison,Jian Feng,Eric J. Nestler
Publisher : Elsevier Inc. Chapters
Release : 2012-12-31
ISBN : 0128058412
Language : En, Es, Fr & De

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Book Description :

Download Epigenetic Regulation in the Nervous System book written by Alfred J. Robison,Jian Feng,Eric J. Nestler, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Epigenetic Regulation in the Nervous System

Epigenetic Regulation in the Nervous System Book
Author : Alexi Nott,Daniel M. Fass,Stephen J. Haggarty,Li-Huei Tsai
Publisher : Elsevier Inc. Chapters
Release : 2012-12-31
ISBN : 0128058439
Language : En, Es, Fr & De

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Book Description :

Download Epigenetic Regulation in the Nervous System book written by Alexi Nott,Daniel M. Fass,Stephen J. Haggarty,Li-Huei Tsai, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Epigenetic Regulation in the Nervous System

Epigenetic Regulation in the Nervous System Book
Author : Isabelle M. Mansuy,Rahia Mashoodh,Frances A. Champagne
Publisher : Elsevier Inc. Chapters
Release : 2012-12-31
ISBN : 012805848X
Language : En, Es, Fr & De

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Book Description :

Download Epigenetic Regulation in the Nervous System book written by Isabelle M. Mansuy,Rahia Mashoodh,Frances A. Champagne, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Transcriptional and Epigenetic Regulation of Axon Regeneration

Transcriptional and Epigenetic Regulation of Axon Regeneration Book
Author : Marcus Mahar
Publisher : Unknown
Release : 2019
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

The mammalian nervous system is a highly intricate network consisting of over a hundred billion specialized cells called neurons. One unique characteristic of neurons is their highly polarized morphology; unlike other cells, neurons project long axonal extensions. These structures allow them to connect and communicate with not only other neurons, but also various cell types in the body and give rise to all motor, sensory, and higher order function. Because axons can extend up to three feet, they are also vulnerable to injury from sources such as traumatic brain and spinal cord injuries, stroke, or neurodegenerative diseases. Indeed, patients who have experienced these injuries often suffer debilitating, irreversible loss of function. Interestingly, whereas neurons which reside in the central nervous system are incapable of regenerating after axon injury, neurons of the peripheral nervous system activate a robust pro-regenerative response capable of promoting long distance regeneration and functional recovery. The molecular mechanisms which underlie this pro-regenerative response may provide key insights into how a pro-regenerative response could be stimulated in injured central nervous system neurons. A comprehensive overview of the known molecular mechanisms involved in this response is reviewed in Chapter 1.As mammals age, the synaptic connections between neurons mature. Following axon injury in peripheral nervous system neurons, the genes involved in synaptic function are turned off and genes required for inducing axon growth are activated. These widespread epigenetic and transcriptional changes require a coordinated effort of epigenetic and transcriptional regulators including epigenetic modifiers, transcription factors, and microRNAs. In Chapter 2, we demonstrated that these changes are, in part, a result of the rapid downregulation of microRNA-9 which occurs following axon injury. At baseline in adult peripheral nervous system neurons, microRNA-9 is highly expressed and actively represses various genes including REST and UHRF1. When microRNA-9 expression decreases following injury, both REST and UHRF1 increase with UHRF1also repressing REST and restricting REST expression to a tight temporal window. During this time, REST binds to and represses various genes involved in synaptic function such as ion channels; a process necessary for peripheral nervous system regeneration. This complete published work can be found in Chapter 2.In coordination with epigenetic modifiers such as UHRF1, various transcription factors are activated following axon injury and promote the expression of pro-growth genes. Various studies have worked to identify the transcription factors involved in this process as exogenous overexpression of transcription factors has been shown to confer specific phenotypes of interest, such as the conversion of one cell type to another, when the correct combination of transcription factors is manipulated. To further this work, in Chapter 3 I used bioinformatics analysis to identify 27 transcription factors putatively involved in the establishment of the pro-regenerative response. Using two complimentary in vitro screens, determined which transcription factors were both necessary for peripheral nervous system axon regeneration and sufficient to drive central nervous system axon regeneration. By pairing these results with network-based bioinformatics analysis, we identified Creb1 as a transcription factor which sits atop the pro-regenerative gene regulatory network. Follow-up studies in which we overexpressed Creb1during optic nerve regeneration demonstrated Creb1 is sufficient to promote central nervous system axon regeneration in vivo. This work provides exciting new insight into the various transcription factors regulating this response as well as their putative genetic relationships.

Epigenetic Regulation of Neural Stem Cell Differentiation

Epigenetic Regulation of Neural Stem Cell Differentiation Book
Author : Hao Wu
Publisher : Unknown
Release : 2009
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Epigenetic Regulation of Neural Stem Cell Differentiation book written by Hao Wu, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Genomics Proteomics and the Nervous System

Genomics  Proteomics  and the Nervous System Book
Author : James D Clelland
Publisher : Springer Science & Business Media
Release : 2010-12-03
ISBN : 9781441971975
Language : En, Es, Fr & De

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Book Description :

This newest volume of Advances in Neurobiology discusses the utilization of genomic and proteomic technologies, to address facets of neurobiology including development and epigenetic regulation, functions in learning and memory, and changes associated with neurological and psychiatric disorders.

Development of the Central Nervous System

Development of the Central Nervous System Book
Author : Michael W. Miller
Publisher : Wiley-Liss
Release : 1992
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Disseminates information pertaining to the normal and abnormal processes involved during the development of the central nervous system. The toxic effects of alcohol or opiate usage on development are explored by examining the clinical manifestations that appear in the children of substance-abusing mothers. Detailed coverage includes individual ontogenetic and developmental processes such as neural chemical differentiation, cell proliferation and migration.

Evaluation of Alterations in DNA Methylation Associated with 2 3 7 8 tetrachlorodibenzo p diozxin TCDD induced Inhibition of Differentiation in Lipopolysaccharide LPS stimulated Murine Splenocytes

Evaluation of Alterations in DNA Methylation Associated with 2 3 7 8 tetrachlorodibenzo p diozxin  TCDD  induced Inhibition of Differentiation in Lipopolysaccharide  LPS  stimulated Murine Splenocytes Book
Author : Emily Ann McClure
Publisher : Unknown
Release : 2010
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Evaluation of Alterations in DNA Methylation Associated with 2 3 7 8 tetrachlorodibenzo p diozxin TCDD induced Inhibition of Differentiation in Lipopolysaccharide LPS stimulated Murine Splenocytes book written by Emily Ann McClure, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Dissertation Abstracts International

Dissertation Abstracts International Book
Author : Anonim
Publisher : Unknown
Release : 2008
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Dissertation Abstracts International book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Three Daughters of NG2

Three Daughters of NG2 Book
Author : Rosemarie Wen-Ting Tsoa
Publisher : Unknown
Release : 2009
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Three Daughters of NG2 book written by Rosemarie Wen-Ting Tsoa, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Analysis of Gene Repression Mechanisms in Peripheral Nerve Myelination

Analysis of Gene Repression Mechanisms in Peripheral Nerve Myelination Book
Author : Gennifer M. Mager
Publisher : Unknown
Release : 2007
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Analysis of Gene Repression Mechanisms in Peripheral Nerve Myelination book written by Gennifer M. Mager, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.