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Epigenetic Mechanisms In The Brain

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Epigenetic Mechanisms in the Brain

Epigenetic Mechanisms in the Brain Book
Author : Andrew J. Kennedy,Gabriella N. L. Chua
Publisher : Academic Press
Release : 2020-06
ISBN : 9780128164976
Language : En, Es, Fr & De

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Book Description :

Epigenetic mechanisms are the biological processes that determine how our genome is used and the same principle can be applied to our neuron genes. In recent findings in the field of neuroepigenetics, it has been determined that our genes encode our memories, transmit information about stressful events, and play apart in our addictions. This book helps to unlock these abstract processes, leading to improved individualized treatments.

Epigenetic Markers in the Postnatal Developing Rat Brain

Epigenetic Markers in the Postnatal Developing Rat Brain Book
Author : Rebecca Kaye Simmons
Publisher : Unknown
Release : 2013
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Epigenetic mechanisms provide a critical and plausible mechanism by which genes and the environment can interact and have been implicated in a number of diseases and disorders. In order to better understand how epigenetic mechanisms go awry in a diseased brain we must first understand how epigenetic mechanisms unfold during normal development. The present body of work begins to examine the role of DNA methylation in normal development and how it may contribute to a rodent model of emotion dysfunction. Using a variety of techniques, we evaluated the transcript, protein and functional output levels of DNA methyltransferase1, -3a, and -3b during several developmental timepoints in the hippocampus, amygdala and several other brain areas of normal rats as well as bred high novelty responding rats and bred low novelty responding rats. Our results lay an important foundation, paving the way for a series of new experiments that can investigate what happens when epigenetic processes go awry during critical neurodevelopmental periods.

The Future of the Brain

The Future of the Brain Book
Author : Gary Marcus,Jeremy Freeman
Publisher : Princeton University Press
Release : 2016-11-08
ISBN : 0691173311
Language : En, Es, Fr & De

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Book Description :

Including a chapter by 2014 Nobel laureates May-Britt Moser and Edvard Moser An unprecedented look at the quest to unravel the mysteries of the human brain, The Future of the Brain takes readers to the absolute frontiers of science. Original essays by leading researchers such as Christof Koch, George Church, Olaf Sporns, and May-Britt and Edvard Moser describe the spectacular technological advances that will enable us to map the more than eighty-five billion neurons in the brain, as well as the challenges that lie ahead in understanding the anticipated deluge of data and the prospects for building working simulations of the human brain. A must-read for anyone trying to understand ambitious new research programs such as the Obama administration's BRAIN Initiative and the European Union's Human Brain Project, The Future of the Brain sheds light on the breathtaking implications of brain science for medicine, psychiatry, and even human consciousness itself. Contributors include: Misha Ahrens, Ned Block, Matteo Carandini, George Church, John Donoghue, Chris Eliasmith, Simon Fisher, Mike Hawrylycz, Sean Hill, Christof Koch, Leah Krubitzer, Michel Maharbiz, Kevin Mitchell, Edvard Moser, May-Britt Moser, David Poeppel, Krishna Shenoy, Olaf Sporns, Anthony Zador.

Genes Brain Function and Behavior

Genes  Brain Function  and Behavior Book
Author : Douglas Wahlsten
Publisher : Academic Press
Release : 2019-03-01
ISBN : 0128128321
Language : En, Es, Fr & De

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Book Description :

Genes, Brain Function, and Behavior offers a concise description of the nervous system that processes sensory input and initiates motor movements. It reviews how behaviors are defined and measured, and how experts decide when a behavior is perturbed and in need of treatment. Behavioral disorders that are clearly related to a defect in a specific gene are reviewed, and the challenges of understanding complex traits such as intelligence, autism and schizophrenia that involve numerous genes and environmental factors are explored. New methods of altering genes offer hope for treating or even preventing difficulties that arise in our genes. This book explains what genes are, what they do in the nervous system, and how this impacts both brain function and behavior. Presents essential background, facts, and terminology about genes, brain function, and behavior Builds clear explanations on this solid foundation while minimizing technical jargon Explores in depth several single-gene and chromosomal neurological disorders Derives lessons from these clear examples and highlights key lessons in boxes Examines the intricacies of complex traits that involve multiple genetic and environmental factors by applying lessons from simpler disorders Explains diagnosis and definition Includes a companion website with Powerpoint slides and images for each chapter for instructors and links to resources

Stress and Brain Health Across the Life Course

Stress and Brain Health  Across the Life Course Book
Author : Nina Smyth
Publisher : Academic Press
Release : 2020-03
ISBN : 0128167521
Language : En, Es, Fr & De

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Book Description :

Stress and Brain Health: Across the Life Course, Volume 150, examines up-to-date knowledge on how stress effects brain health. The book's wide-ranging topics include the effects of pre-natal and childhood stress on neurodevelopment and aging. Chapters cover What is stress, how to measure it and effects on brain function, Pre-natal effects of stress on brain development and vulnerability, Stress in childhood, sensitive periods and regulatory mechanisms, The impact of childhood poverty on brain health, Adverse childhood experiences (ACE) on the brain, Stress, aging and epigenetics, The effects of chronic stress on the prefrontal cortex, Neurobiology of resilience to stress, and more.

The Evolution of the Sensitive Soul

The Evolution of the Sensitive Soul Book
Author : Simona Ginsburg,Eva Jablonka
Publisher : MIT Press
Release : 2019-03-12
ISBN : 0262039303
Language : En, Es, Fr & De

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Book Description :

A new theory about the origins of consciousness that finds learning to be the driving force in the evolutionary transition to basic consciousness. What marked the evolutionary transition from organisms that lacked consciousness to those with consciousness—to minimal subjective experiencing, or, as Aristotle described it, “the sensitive soul”? In this book, Simona Ginsburg and Eva Jablonka propose a new theory about the origin of consciousness that finds learning to be the driving force in the transition to basic consciousness. Using a methodology similar to that used by scientists when they identified the transition from non-life to life, Ginsburg and Jablonka suggest a set of criteria, identify a marker for the transition to minimal consciousness, and explore the far-reaching biological, psychological, and philosophical implications. After presenting the historical, neurobiological, and philosophical foundations of their analysis, Ginsburg and Jablonka propose that the evolutionary marker of basic or minimal consciousness is a complex form of associative learning, which they term unlimited associative learning (UAL). UAL enables an organism to ascribe motivational value to a novel, compound, non-reflex-inducing stimulus or action, and use it as the basis for future learning. Associative learning, Ginsburg and Jablonka argue, drove the Cambrian explosion and its massive diversification of organisms. Finally, Ginsburg and Jablonka propose symbolic language as a similar type of marker for the evolutionary transition to human rationality—to Aristotle's “rational soul.”

The Oxford Handbook of Emotion Dysregulation

The Oxford Handbook of Emotion Dysregulation Book
Author : Theodore P. Beauchaine,Sheila E. Crowell,Sheila Elizabeth Crowell
Publisher : Oxford University Press, USA
Release : 2020
ISBN : 0190689285
Language : En, Es, Fr & De

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Book Description :

"The Oxford Handbook of Emotion Dysregulation is the first to consider the ED construct as distinct from what is known as emotion regulation (ER; a variety of automatic and volitional strategies, behaviors, and skills that are used to modulate emotional experiences and expressions), featuring chapters by scholars whose work is on the cutting edge of basic and clinical understanding of ED. This Handbook examines the ED construct from multiple viewpoints across levels of analysis and considers the role that ED plays in the expression of various forms of psychopathology. Chapters explore basic understanding of emotions and ED as transdiagnostic constructs (Part I); cognitive, behavioral, and social approaches to evaluating ED (Part II); neurobiological advances in our understanding of ED (Part III); associations between ED and psychopathology (Part IV); and assessment and treatment of ED (Part V). Part VI includes chapters on Conclusions and Future Directions. The Handbook can serve as a primary or complementary text for advanced undergraduate and graduate-level seminars/courses on emotion dysregulation and psychopathology more broadly"--

DNA Modifications in the Brain

DNA Modifications in the Brain Book
Author : Timothy W Bredy
Publisher : Academic Press
Release : 2016-12-23
ISBN : 0128017813
Language : En, Es, Fr & De

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Book Description :

DNA Modifications in the Brain: Neuroepigenetic Regulation of Gene Expression begins with an historical overview of the early discoveries surrounding DNA methylation in the mammalian brain and then explores the evidence supporting a role for this epigenetic mechanism in controlling gene expression programs across the lifespan in both normal and diseased states. Chapters describe new directions and technological advances, and provide an overview of what the future holds for this exciting new field. This book is ideal for medical, graduate and advanced undergraduate students, but is also a great resource for researchers who need a broad introduction to the dynamic nature of DNA that sheds light on evolving concepts of gene-environment interaction and their effects on adaptation and neuropsychiatric disease. Provides a comprehensive overview of the many facets of DNA modifications Discusses the impact of this dynamic epigenetic mechanism across brain development and lifespan at behavioral, cognitive, molecular and genetic levels Contains contributions by influential leaders in the field Edited by a Neuroscientist to further promote synthesis between epigenetics, neuroscience, and clinical relevance

Behavioural Brain Research in Naturalistic and Semi Naturalistic Settings

Behavioural Brain Research in Naturalistic and Semi Naturalistic Settings Book
Author : North Atlantic Treaty Organization. Scientific Affairs Division
Publisher : Springer
Release : 1995-07-31
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Proceedings of the NATO Advanced Study Institute on `Behavioural Brain Research in Naturalistic and Semi-Naturalistic Settings: Possibilities and Perspectives', Acquafredda di Maratea, Italy, September 10--20, 1994

Epigenetic Mechanisms of Gene Regulation

Epigenetic Mechanisms of Gene Regulation Book
Author : Vincenzo E. A. Russo,Robert A. Martienssen,Arthur D. Riggs
Publisher : Unknown
Release : 1996
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Many inheritable changes in gene function are not explained by changes in the DNA sequence. Such epigenetic mechanisms are known to influence gene function in most complex organisms and include effects such as transposon function, chromosome imprinting, yeast mating type switching and telomeric silencing. In recent years, epigenetic effects have become a major focus of research activity. This monograph, edited by three well-known biologists from different specialties, is the first to review and synthesize what is known about these effects across all species, particularly from a molecular perspective, and will be of interest to everyone in the fields of molecular biology and genetics.

Brain Tumors

Brain Tumors Book
Author : Davide Schiffer
Publisher : Springer
Release : 1996-12-12
ISBN : 9783540616221
Language : En, Es, Fr & De

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Book Description :

Analogue to the first edition, the principal characteristic of this work is its casting of pathology as the common nosographic link in the diagnosis, prognosis and treatment of brain tumours. A result of the author's many years of experience in the study of brain tumours and their pathological and clinical characteristics, the book presents different aspects of neurooncology from the perspective of pathology and its biological and clinical correlates. This new, second and enlarged volume preserves all the qualities of the first edition while further amplifying clinical applications and updating biological and pathological problems. The references have been completely revised and new chapters have been added on topics such as neuroimaging, invasion and angiogenesis. Professor Schiffer is President of the Italian Association of Neurooncology and of the Italian Association of Neuropathology.

Molecular Mechanisms Controlling Epigenetic Stability of Gene Expression

Molecular Mechanisms Controlling Epigenetic Stability of Gene Expression Book
Author : Lee Nicholas Lawton
Publisher : Unknown
Release : 2004
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Molecular Mechanisms Controlling Epigenetic Stability of Gene Expression book written by Lee Nicholas Lawton, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Epigenetic Regulation in the Nervous System

Epigenetic Regulation in the Nervous System Book
Author : J. David Sweatt,Michael J. Meaney,Eric J. Nestler,Schahram Akbarian
Publisher : Academic Press
Release : 2012-12-31
ISBN : 0123944058
Language : En, Es, Fr & De

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Book Description :

Epigenetic Regulation in the Nervous System addresses current understanding of the roles of epigenetic processes at the molecular/cellular level, their impact on neural development and behavior, and the potential roles of these mechanisms in neurological and psychiatric disorders. This award-winning volume spans molecular epigenetics, development, cellular physiology and biochemistry, synaptic and neural plasticity, and behavioral models, and is unique in covering epigenetically based disorders of the central nervous system. Behavioral epigenetics is the study of how environmental factors alter behavior, addressing the fundamental mechanisms that shape development and individual vulnerability/resilience to adverse behavioral outcomes. By understanding the molecular mechanisms involved in epigenetic modulation, researchers may be able to develop targeted therapies for those individuals in whom it malfunctions. Edited by the most highly regarded leaders in the field, this book offers a comprehensive review of behavioral epigenetics and a balanced treatment of the strengths and weaknesses in experimentation in this area. Covering background material as well as topics of current interest, it serves both as a cutting-edge resource and a foundational reference. The book will benefit neuroscience researchers and graduate students with an interest in the links between gene regulation and behavior, as will clinicians dealing with disorders such as addiction, depression, and schizophrenia. BMA Medical Book Awards 2014 - Highly Commended, Neurology, British Medical Association BMA Medical Book Awards 2014 - First Prize, Neurology, British Medical Association 2013 PROSE Award winner for Best in Reference Works and Best Single Volume Reference in Science from the Association of American Publishers Presents a unified view of epigenetic mechanisms from behavior to genes and everything in between Discusses clinically relevant disorders in the context of epigenetics research, making the volume appealing to clinicians as well as basic scientists Provides numerous practical examples for the new investigator to facilitate implementation of research in neuroepigenetics

Genomic Imprinting

Genomic Imprinting Book
Author : Hiroyuki Sasaki,Fumitoshi Ishino
Publisher : S Karger Ag
Release : 2006
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Genomic imprinting, a parent-of-origin-specific epigenetic modification of the genome, is observed in placental mammals and some plants (angiosperms). Since its discovery in the early 1980s, this intriguing phenomenon has been intensively investigated and has spawned an exciting new research area. Imprinting is relevant to a variety of biological events such as embryogenesis, growth and behavior, and its disruption can lead to congenital malformation syndromes and cancers. Furthermore, imprinting has been serving as an excellent model system to study epigenetic mechanisms of gene regulation and helping us to understand how gene clusters and genome domains are regulated. This special issue provides an overview of the current knowledge of genomic imprinting. Including both excellent reviews and original research articles by outstanding researchers in the field, many of which were participants of the genomic imprinting workshops in Montpellier (September 2004) and Oxford (April 2005), it represents the forefront of imprinting research.

Epigenetic pathways in PTSD how traumatic experiences leave their signature on the genome

Epigenetic pathways in PTSD  how traumatic experiences leave their signature on the genome Book
Author : Tania L Roth,David M Diamond,Karestan C Koenen
Publisher : Frontiers Media SA
Release : 2015-04-14
ISBN : 2889194582
Language : En, Es, Fr & De

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Book Description :

This research topic focuses on epigenetic components of PTSD. Epigenetic mechanisms are a class of molecular mechanisms by which environmental influences, including stress, can interact with the genome to have long-term consequences for brain plasticity and behavior. Articles herein include empirical reports and reviews that link stress and trauma with epigenetic alterations in humans and animal models of early- or later-life stress. Themes present throughout the collection include: DNA methylation is a useful biomarker of stress and treatment outcome in humans; epigenetic programming of stress-sensitive physiological systems early in development confers an enhanced risk on disease development upon re-exposure to trauma or stress; and, long-lived fear memories are associated with epigenetic alterations in fear memory and extinction brain circuitry.

Genetic Engineering Biotechnology News

Genetic Engineering   Biotechnology News Book
Author : Anonim
Publisher : Unknown
Release : 2009
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Genetic Engineering Biotechnology News book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Indian Journal of Medical Research

Indian Journal of Medical Research Book
Author : Anonim
Publisher : Unknown
Release : 2007
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Indian Journal of Medical Research book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Hastings Law Journal

Hastings Law Journal Book
Author : Anonim
Publisher : Unknown
Release : 2012
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Hastings Law Journal book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

The Hastings Law Journal

The Hastings Law Journal Book
Author : Anonim
Publisher : Unknown
Release : 2013
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download The Hastings Law Journal book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.