Skip to main content

Epigenetic Cancer Therapy

In Order to Read Online or Download Epigenetic Cancer Therapy Full eBooks in PDF, EPUB, Tuebl and Mobi you need to create a Free account. Get any books you like and read everywhere you want. Fast Download Speed ~ Commercial & Ad Free. We cannot guarantee that every book is in the library!

Epigenetic Cancer Therapy

Epigenetic Cancer Therapy Book
Author : Steven Gray
Publisher : Academic Press
Release : 2015-07-01
ISBN : 0128002247
Language : En, Es, Fr & De

GET BOOK

Book Description :

Epigenetic Cancer Therapy unites issues central to a translational audience actively seeking to understand the topic. It is ideal for cancer specialists, including oncologists and clinicians, but also provides valuable information for researchers, academics, students, governments, and decision-makers in the healthcare sector. The text covers the basic background of the epigenome, aberrant epigenetics, and its potential as a target for cancer therapy, and includes individual chapters on the state of epigenome knowledge in specific cancers (including lung, breast, prostate, liver). The book encompasses both large-scale intergovernmental initiatives as well as recent findings across cancer stem cells, rational drug design, clinical trials, and chemopreventative strategies. As a whole, the work articulates and raises the profile of epigenetics as a therapeutic option in the future management of cancer. Concisely summarizes the therapeutic implications of recent, large-scale epigenome studies, including the cancer epigenome atlas Discusses targeted isoform specific versus pan-specific inhibitors, a rational drug design approach to epigenetics relevant to pharmacoepigenetic clinical applications Covers new findings in the interplay between cancer stem cells (CSCs) and drug resistance, demonstrating that epigenetic machinery is a candidate target for the eradication of these CSCs

Epigenetic Therapy of Cancer

Epigenetic Therapy of Cancer Book
Author : Michael Lübbert,Peter A. Jones
Publisher : Springer Science & Business Media
Release : 2013-12-12
ISBN : 3642384048
Language : En, Es, Fr & De

GET BOOK

Book Description :

The growing knowledge about disturbances of epigenetic gene regulation in hematopoietic stem cell disorders is now being translated into treatment approaches that target the epigenetic defects pharmacologically. This book first presents the latest evidence regarding the epigenetic regulation of hematopoietic stem cell differentiation and hemoglobin production. The significance of DNA methylation abnormalities in hematopoietic disorders and of epigenetic disturbances in lung cancer and other solid tumors is then discussed. A major part of the book, however, relates specifically to the translation of basic research and drug development to clinical applications, and in this context both present and future clinical strategies are considered. Individual chapters are devoted to the use of DNA hypomethylating agents and chromatin-modifying agents, and the treatment of hematologic malignancies and solid tumors by means of epigenetic agents is discussed in detail.

Cancer Epigenetics

Cancer Epigenetics Book
Author : Trygve Tollefsbol
Publisher : CRC Press
Release : 2019-08-30
ISBN : 9780367386863
Language : En, Es, Fr & De

GET BOOK

Book Description :

During the past few decades, it has become increasingly apparent that heredity is not the sole determining factor in disease development, such as cancer. This landmark work covers a wide array of aspects in the relatively new area of epigenetics, ranging from its role in the basic mechanisms of tumorigenesis, to the newest epigenetic drugs being developed and used for cancer therapy. Cancer Epigenetics presents in-depth discussions of DNA methylation alterations, histone and RNA modifications, and nucleosome remodeling, which are all intimately involved in the formation of tumors. It also analyzes metabolic influences on cancer epigenetics and advances in epigenetic cancer gene therapy. Discusses the Latest Advances in the Role of Epigenetics in Tumor Initiation, Progression, and Metastasis With stand-alone chapters written by research pioneers in the field, this definitive resource covers-- DNA methylation and cancer Histone modifications in cancer Emerging areas of cancer epigenetics Epigenetics in the diagnosis, prognosis, and therapy of cancer Future directions in epigenetic cancer research Bringing together different topics into a single compilation, this text is a prime resource for those with interests ranging from the basic mechanisms of tumor biology to cancer therapy. It also serves as a core textbook for advanced courses with a focus on genetic diseases, molecular biology, and/or cancer. This seminal work answers the call for a thorough and authoritative reference that covers the critical and contemporary aspects of this revolutionary field.

The Histone Code and Beyond

The Histone Code and Beyond Book
Author : Shelley L. Berger,O. Nakanishi,Bernhard Haendler
Publisher : Springer Science & Business Media
Release : 2007-01-19
ISBN : 354037633X
Language : En, Es, Fr & De

GET BOOK

Book Description :

Methylation of DNA at cytosine residues as well as post-translational modifications of histones, including phosphorylation, acetylation, methylation and ubiquitylation, contribute to the epigenetic information carried by chromatin. These changes play an important role in the regulation of gene expression by modulating the access of regulatory factors to the DNA. The use of a combination of biochemical, genetic and structural approaches has allowed demonstration of the role of chromatin structure in transcriptional control. The structure of nucleosomes has been elucidated and enzymes involved in DNA or histone modifications have been extensively characterized. Since deregulation of epigenetic marks has been reported in many cancers, a better understanding of the underlying molecular mechanisms bears the promise that new drug targets may soon be found. The newest developments in this quickly developing field are presented in this book.

Epigenetic Therapy with Histone Deacetylase Inhibitors Implications for Cancer Treatment

Epigenetic Therapy with Histone Deacetylase Inhibitors  Implications for Cancer Treatment Book
Author : Christiane Pienna Soares,Jean Leandro Dos Santos,Ângela Sousa
Publisher : Frontiers Media SA
Release : 2021-06-02
ISBN : 2889668355
Language : En, Es, Fr & De

GET BOOK

Book Description :

Download Epigenetic Therapy with Histone Deacetylase Inhibitors Implications for Cancer Treatment book written by Christiane Pienna Soares,Jean Leandro Dos Santos,Ângela Sousa, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Epigenetics and Cancer

Epigenetics and Cancer Book
Author : Fazlul H. Sarkar
Publisher : Springer Science & Business Media
Release : 2013-05-29
ISBN : 9400766122
Language : En, Es, Fr & De

GET BOOK

Book Description :

Overall, this book illustrates the complexities of the regulation and deregulation of genes mediated through epigenetics in the development and progression of human malignancies. All the articles have been carefully chosen to represent several cancer systems with state of our knowledge on the role of epigenetic deregulation of microRNAs (miRNAs) and their target mRNAs along with epigenetic deregulation of mRNAs. This book also illustrates the role of several dietary agents, collectively called nutraceuticals or natural agents in modulating the epigenetic reprogramming of miRNAs and mRNAs for the prevention and/or treatment of human malignancies. It is well known that genetic aberrations, especially inherited through parents (somatic genetic alterations) contribute to the development of less than 10% of all cancer yet epigenetic alterations in genes especially through selective methylation and acetylation appears to be responsible for the development and progression of the vast majority of all cancers. Therefore, understanding the role of epigenetics in the regulation of genes especially through deregulated expression of miRNAs as presented in this book will allow scientists to devise targeted therapeutic strategies for re-expression of the lost genes or down-regulate the genes that are over-expressed in order to eradicate cancer. It is hoped that targeting epigenetics will not only target cancer cells but it will also target the tumor microenvironment (more like the entire tumor environment such as the entire host) for achieving better treatment outcomes for patients diagnosed with cancer which will lead to achieve the long-term objective for complete eradication of cancer. This book contains fifteen chapters which begins with the concept of systems and network biology for investigating the epigenetics of cancer followed by a series of articles on the role of miRNAs and their target genes in the biology of pancreatic cancer and other cancers such as breast, kidney, prostate and and colon. Since it is becoming increasingly clear that cancer stem cells (CSCs) are important in the development and progression of cancer, and CSCs are important in therapeutic resistance, treatment failure and tumor recurrence, thus the importance of CSCs and epigenetics has been highlighted by a very timely article on epigenetic variations of stem cell markers in cancer including miRNAs. Moreover, just targeting heterogeneous cancer cell populations may not be optimal to eradicate tumors and for which one must take a holistic approach for developing drugs that could also target the tumor microenvironment and tumor dormancy that are regulated through epigenetics. Keeping abreast with this thought process the concluding chapter provides a concept towards curative cancer therapy with maspin, which could be a unique window of opportunity to target tumor dormancy. Therefore, it suggest that targeting the tumor dormancy and the tumor microenvironment using novel therapeutics specifically by targeting epigenetics would become the future of medicine.

Epigenetics in Cancer

Epigenetics in Cancer Book
Author : Junjiang Fu,Saber Imani
Publisher : Alpha Science International, Limited
Release : 2019-04-30
ISBN : 9781783323593
Language : En, Es, Fr & De

GET BOOK

Book Description :

As the second leading cause of death, cancer has cast an overwhelming shadow on millions of lives worldwide. Everyone is affected in some way, if not by having the disease themselves, then by witnessing it in friends or loved ones. Epigenetics is a rapidly-growing field and a fascinating area of cancer research. The book addresses the importance of fighting cancers with an epigenetics approach. Specifically, the following topics are reviewed: - (1) DNA methylation and cancer. - (2) Non-coding RNAs in cancer. - (3) Epigenetics in the diagnosis, prognosis, and therapy of cancer. - (4) Epigenetic effects of environmental and dietary factors in cancer. The book also includes a chapter that provides short but practical protocols widely used in epigenetics research. Finally, it provides insight into future directions in cancer epigenetics research. Thus, this book covers a wide range of topics, from general mechanisms of cancer epigenetics to cancer therapy. This book will be helpful to improve the understanding of epigenetics and cancer who are interested in cancer epigenetics and the development of anticancer drugs at various levels, including students in medical and biological fields, postdoctoral fellows, university researchers, and/or educators.

Cancer Epigenetics

Cancer Epigenetics Book
Author : Antonio Giordano,Marcella Macaluso
Publisher : John Wiley & Sons
Release : 2011-10-07
ISBN : 9781118005736
Language : En, Es, Fr & De

GET BOOK

Book Description :

Cancer Epigenetics: Biomolecular Therapeutics in Human Cancer is the only resource to focus on biomolecular approaches to cancer therapy. Its presentation of the latest research in cancer biology reflects the interdisciplinary nature of the field and aims to facilitate collaboration between the basic, translational, and clinical sciences.

Epigenetic Approaches to Cancer Therapy

Epigenetic Approaches to Cancer Therapy Book
Author : Nicola Louise Steele
Publisher : Unknown
Release : 2006
ISBN : 0987650XXX
Language : En, Es, Fr & De

GET BOOK

Book Description :

Download Epigenetic Approaches to Cancer Therapy book written by Nicola Louise Steele, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Epigenetics of Cancer Prevention

Epigenetics of Cancer Prevention Book
Author : Anupam Bishayee,Deepak Bhatia
Publisher : Academic Press
Release : 2018-11-27
ISBN : 0128125667
Language : En, Es, Fr & De

GET BOOK

Book Description :

Epigenetics of Cancer Prevention, Volume Ten is the first to look at epigenetics and chemoprevention together. Although there is numerous scientific data available on how epigenetics can lead to cancer and how chemoprevention can be beneficial in the treatment of, or improvement of quality of life, together they will set an advanced understanding for the reader in this upcoming field of chemoprevention influencing epigenetics. This book discusses molecular epigenetic targets of natural products, such as green tea polyphenols, curcumin and resveratrol, and organ specific epigenetic targets related to diverse types of cancer, for example prostate, colorectal, breast, lung and skin cancers. Additionally, it encompasses a discussion on research methods and limitations to study epigenetics and epigenomics of chemopreventive drugs and personalized cancer treatment with phytochemicals. The book is ideal for cancer researchers, health care professionals and all individuals who are interested in cancer prevention research and its clinical applications, especially in natural remedies. Lists natural agents, including nutraceuticals, and their effects on normal or tumor genome Addresses various epigenetic systems and mechanisms in the regulation and support of the mammalian genome Discusses how various parts of dietary phytochemicals can influence or modify epigenetic mechanisms in several types of cancer

DNA Methylation and Cancer Therapy

DNA Methylation and Cancer Therapy Book
Author : Moshe Szyf
Publisher : Springer Science & Business Media
Release : 2007-04-03
ISBN : 038727443X
Language : En, Es, Fr & De

GET BOOK

Book Description :

NA methylation has bewildered molecular biologists since Hotchkiss discovered it almost six decades ago (Hotchkiss RDJ. Biol Cem 1948; 175:315-332). The fact that the chemical structure of our D genome consists of two components that are covalently bound, the genetic information that is replicated by the DNA replication machinery ana DNA methylation that is maintainea by independent enzymatic machinery, has redictably stimulated the imagination and curiosity of generations of mo Edular biologists. An obvious question was whether DNA methylation was a bearer of additional information to the genetic information and what was the nature of this information? It was tempting to speculate that DNA me thylation applied some form of control over programming of the genome s expression profile. Once techniques to probe the methylation profile of whole genomes as well as specific genes became available, it became clear that DNA methylation patterns are gene and tissue specific and that patterns of gene expression correlate with patterns of methylation. DNA methylation pat terns emerged as the only component of the chemical structure of DNA that exhibited tissue and cell specificity. This data seemingly provided an attrac tively simple explanation for the longstanding dilemma of how could one identical genome manifest itself in so many different forms in multicellular organisms? The DNA methylation pattern has thus become the only known factor to confer upon DNA a unique cellular identity.

Alterations of Epigenetics and MicroRNAs in Cancer and Cancer Stem Cell

Alterations of Epigenetics and MicroRNAs in Cancer and Cancer Stem Cell Book
Author : Yoshimasa Saito
Publisher : Frontiers E-books
Release : 2014-11-10
ISBN : 2889193454
Language : En, Es, Fr & De

GET BOOK

Book Description :

Studies have shown that alterations of epigenetics and microRNAs (miRNAs) play critical roles in the initiation and progression of human cancer. Epigenetic silencing of tumor suppressor genes in cancer cells is generally mediated by DNA hypermethylation of CpG island promoter and histone modification such as methylation of histone H3 lysine 9 (H3K9) and tri-methylation of H3K27. MiRNAs are small non-coding RNAs that regulate expression of various target genes. Specific miRNAs are aberrantly expressed and play roles as tumor suppressors or oncogenes during carcinogenesis. Important tumor suppressor miRNAs are silenced by epigenetic alterations, resulting in activation of target oncogenes in human malignancies. Stem cells have the ability to perpetuate themselves through self-renewal and to generate mature cells of various tissues through differentiation. Accumulating evidence suggests that a subpopulation of cancer cells with distinct stem-like properties is responsible for tumor initiation, invasive growth, and metastasis formation, which is defined as cancer stem cells. Cancer stem cells are considered to be resistant to conventional chemotherapy and radiation therapy, suggesting that these cells are important targets of cancer therapy. DNA methylation, histone modification and miRNAs may be deeply involved in stem-like properties in cancer cells. Restoring the expression of tumor suppressor genes and miRNAs by chromatin modifying drugs may be a promising therapeutic approach for cancer stem cells. In this Research Topic, we discuss about alterations of epigenetics and miRNAs in cancer and cancer stem cell and understand the molecular mechanism underlying the formation of cancer stem cell, which may provide a novel insight for treatment of refractory cancer.

Epigenetics in Cancer

Epigenetics in Cancer Book
Author : Sue Ping Lim
Publisher : Unknown
Release : 2012
ISBN : 0987650XXX
Language : En, Es, Fr & De

GET BOOK

Book Description :

This thesis investigates epigenetics in cancer with particular emphasis on breast cancer. There are two major themes, see Figure above. The first theme relates to the potential for assessing and developing more efficient epigenetic drugs while the second theme investigates mechanism of downregulation of ANKRD11, a putative tumour suppressor gene, in human breast cancer. This thesis is in the publication format with Chapters 1 and 3 as published articles, Chapter 2 submitted for publication and Chapter 4 as a manuscript in preparation. Theme 1: To improve the epigenetic-based therapeutic approach (Chapter 1 and 2). One of the roles that epigenetics plays in cancer development is the inhibition of transcription of tumour suppressor genes. Chapter 1, published as a review in Biodrugs, examines the knowledge of currently available therapeutic approaches related to epigenetic mechanisms such as DNA methylation for cancer treatment. Drug-related issues that could influence the application of therapeutics for clinical use are reviewed and possible developments to improve the clinical use of the drugs explored. Epigenetic-based drugs are emerging as anti-cancer therapies in the clinic. Existing demethylating agents have poor pharmacological properties that limit their clinical use, and the application of nano-based encapsulation to resolve these issues is discussed. Chapter 2, submitted as an original research article to Biodrugs, presents the development and assessment of an assay to allow comparison of epigenetic-related drugs in a high throughput format. Decitabine is encapsulated in a liposomal formulation and the potency of this newly formulated decitabine and existing drugs are effectively compared using the developed assay system. Further development and validation of the assay system and the liposomal formulated decitabine, not included in the submitted manuscript are included as supplementary data. Theme 2: Investigation of gene silencing mechanism of tumour suppressor ANKRD11 (Chapter 3 and 4). ANKRD11 is novel gene that was previously characterised in our laboratory, and found to be a putative tumour suppressor gene and a p53-coactivator (Neilsen et al. 2008). Chapter 3, published in European Journal of Cancer, investigates the mechanism of downregulation of ANKRD11 in human breast cancer. This chapter identifies the promoter sequence of ANKRD11, demonstrates the critical region of the ANKRD11 promoter subjected to DNA methylation, and associates the DNA methylation levels of ANKRD11 with its gene expression and clinical data. Further analysis of the DNA methylation pattern of this gene revealed a putative GLI1 transcription-factor binding site within the localised region of the promoter that is methylated. Chapter 4, presented as a manuscript in preparation, further explores the relationship between ANKRD11 and GLI1 in breast cancer. GLI1 is a Hedgehog signalling transcription factor, which has been shown to be involved in breast cancer development. This study analyses the transcriptional activity of ANKRD11 in the cells overexpressed with GLI1 and quantifies differential expression of these two genes in different stages of breast cancer. Future experiments to confirm and extend these exciting preliminary findings are discussed. The final chapter of this thesis summarises the findings of these studies and possible future research directions. The impact of these findings for the development of anti-cancer drugs, and the possible role of expression of ANKRD11 and GLI1 in breast cancer are highlighted.

Cell Press Reviews Cancer Therapeutics

Cell Press Reviews  Cancer Therapeutics Book
Author : Cell Press
Publisher : Elsevier
Release : 2013-12-10
ISBN : 0127999175
Language : En, Es, Fr & De

GET BOOK

Book Description :

Cell Press Reviews: Cancer Therapeutics informs, inspires, and connects cancer researchers at all stages in their careers with timely, comprehensive reviews written by leaders in the field and curated by Cell Press editors. The publicatio offers a broad view of some of the most compelling topics in cancer therapeutics including: Genetic approaches for personal oncology Targeting epigenetic dysregulation and protein interaction networks Vaccines and antibodies in cancer immunotherapy Tumor heterogeneity and chemotherapy resistance Tumor associated macrophages in anticancer treatment Contributions come from leading voices in the field, including: - Daniel A. Haber, Director of Massachusetts General Hospital Cancer Center and Professor at Harvard Medical School - Tony Kouzarides, Professor at the University of Cambridge, Deputy Director of the Wellcome Trust/Cancer Research UK Gurdon Institute, and a founder of the cancer drug discovery company Chroma Therapeutics - Charles L. Sawyers, Chair of the Human Oncology and Pathogenesis Program at Memorial Sloan Kettering Cancer Center, President of the American Association for Cancer Research, member of the presidentially appointed National Cancer Advisory Board, and recipient of the 2013 Breakthrough Prize in Life Sciences Cell Press Reviews: Cancer Therapeutics is part of the Cell Press Reviews series, which features reviews published in Cell Press primary research and Trends reviews journals. Provides timely, comprehensive articles on a wide range of topics in cancer therapeutics Offers insight from experts on genetic, molecular, and cellular aspects of cancer therapy Features reviews on basic science advances translated into drug discovery and therapeutic approaches Includes articles originally published in Cell, Cancer Cell, Trends in Genetics, Trends in Molecular Medicine, and Trends in Pharmacological Sciences

The Histone Code and Beyond

The Histone Code and Beyond Book
Author : Shelley L. Berger,O. Nakanishi,Bernhard Haendler
Publisher : Springer
Release : 2009-09-02
ISBN : 9783540813231
Language : En, Es, Fr & De

GET BOOK

Book Description :

Methylation of DNA at cytosine residues as well as post-translational modifications of histones, including phosphorylation, acetylation, methylation and ubiquitylation, contribute to the epigenetic information carried by chromatin. These changes play an important role in the regulation of gene expression by modulating the access of regulatory factors to the DNA. The use of a combination of biochemical, genetic and structural approaches has allowed demonstration of the role of chromatin structure in transcriptional control. The structure of nucleosomes has been elucidated and enzymes involved in DNA or histone modifications have been extensively characterized. Since deregulation of epigenetic marks has been reported in many cancers, a better understanding of the underlying molecular mechanisms bears the promise that new drug targets may soon be found. The newest developments in this quickly developing field are presented in this book.

Epigenetic Mechanisms in Cancer

Epigenetic Mechanisms in Cancer Book
Author : Sabita Saldanha
Publisher : Academic Press
Release : 2017-11-16
ISBN : 0128134607
Language : En, Es, Fr & De

GET BOOK

Book Description :

Epigenetic Mechanisms in Cancer provides a comprehensive analysis of epigenetic signatures that govern disease development, progression and metastasis. Epigenetic signatures dictating tumor etiologies present an opportunity for biomarker identification which has broad potential for improving diagnosis, prognosis, prediction, and risk assessment. This volumes offers a unique evaluation of signature differences in childhood, sex-specific and race-specific cancers, and in doing so broadly illuminates the scope of epigenetic biomarkers in clinical environments. Chapters detail the major epigenetic process in humans consisting of DNA methylation, histone modifications and microRNAs (miRNAs) involved in the initiation, progression and metastasis of tumors. Also delineated are recent technologies such as next generation sequencing that are used to identify epigenetic profiles (primarily methylation analysis) in samples (normal, benign and cancerous) and which are highly important to the analysis of epigenetic outcomes. Offers broad coverage that is applicable to audiences in various area of cancer research - population studies, diagnostics, prognosis, prediction, therapy, risk, etc. Provides critical review analysis of the topics that will clarify and delineate the potential roles of epigenetic signatures in cancer management Covers basic, as well as, clinical areas of epigenetic mechanisms in tumorigenesis Features contributions by leading experts in the field Provides comprehensive coverage of current epigenetic signatures involved in the etiology of various cancers and miRNAs

Molecular mechanisms and physiology of disease

Molecular mechanisms and physiology of disease Book
Author : Nilanjana Maulik,Tom Karagiannis
Publisher : Springer
Release : 2014-05-31
ISBN : 1493907069
Language : En, Es, Fr & De

GET BOOK

Book Description :

In a simplified form, epigenetics refers to heritable changes in phenotype that are not due to changes in the underlying DNA sequence. In this book, epigenetic mechanisms of regulation and dysregulation in health and disease are explored in great depth. Detailed chapters on epigenetic processes including DNA methylation and chromatin post-translational modifications including potential interventions with DNA methyltransferase inhibitors and histone deacetylase inhibitors are explored in initial chapters. These provide a detailed overview and important background to the entire field. The book is then focussed on epigenetic mechanisms involved in various diseases including anti-inflammatory and autoimmune conditions. Important accounts relating to the effects of epigenetics in metabolic syndrome, cardiovascular disease and asthma are the focus of subsequent chapters. The role of epigenetic dysregulation in malignancy is a current topic of interest and represents an intense field of research. A large component of this book is dedicated to the analysis of aberrant epigenetic processes in carcinogenesis and cancer progression. Further, chapters are focused on emerging cancer prevention using nutritional components and anti-cancer therapies particularly with histone deacetylase inhibitors, which have already been approved for the treatment of cutaneous T-cell lymphoma. The emerging role of nanoparticle preparations, especially in the context of delivering potential epigenetic therapies to target cells in various diseases, is also explored in this book. Overall, this book encompasses a wide range of topics related to epigenetic mechanisms in health and disease and would appeal to anyone with an interest in epigenetics, chromatin biology and emerging epigenetic interventions and therapies.

Epigenetic Heterogeneity in Cancer and Cancer Therapy

Epigenetic Heterogeneity in Cancer and Cancer Therapy Book
Author : David Brocks
Publisher : Unknown
Release : 2016
ISBN : 0987650XXX
Language : En, Es, Fr & De

GET BOOK

Book Description :

Download Epigenetic Heterogeneity in Cancer and Cancer Therapy book written by David Brocks, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Drug Discovery in Cancer Epigenetics

Drug Discovery in Cancer Epigenetics Book
Author : Gerda Egger,Paola Arimondo
Publisher : Academic Press
Release : 2015-11-19
ISBN : 0128024925
Language : En, Es, Fr & De

GET BOOK

Book Description :

Drug Discovery in Cancer Epigenetics is a practical resource for scientists involved in the discovery, testing, and development of epigenetic cancer drugs. Epigenetic modifications can have significant implications for translational science as biomarkers for diagnosis, prognosis or therapy prediction. Most importantly, epigenetic modifications are reversible and epigenetic players are found mutated in different cancers; therefore, they provide attractive therapeutic targets. There has been great interest in developing and testing epigenetic drugs, which inhibit DNA methyltransferases, histone modifying enzymes or chromatin reader proteins. The first few drugs are already FDA approved and have made their way into clinical settings. This book provides a comprehensive summary of the epigenetic drugs currently available and aims to increase awareness in this area to foster more rapid translation of epigenetic drugs into the clinic. Highlights the potential of epigenetic alterations in cancer for drug development Covers the tools and methods for epigenetic drug discovery, preclinical and clinical testing, and clinical implications of epigenetic therapy Provides important information regarding putative epigenetic targets, epigenetic technologies, networks and consortia for epigenetic drug discovery and routes for translation

Epigenetics in Biology and Medicine

Epigenetics in Biology and Medicine Book
Author : Manel Esteller
Publisher : CRC Press
Release : 2008-09-17
ISBN : 9781420007077
Language : En, Es, Fr & De

GET BOOK

Book Description :

Anomalous epigenetic patterns touch many areas of study including biomedical, scientific, and industrial. With perspectives from international experts, this resource offers an all-inclusive overview of epigenetics, which bridge DNA information and function by regulating gene expression without modifying the DNA sequence itself. Epigenetics, in its