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Epi Informatics

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Epi Informatics

Epi Informatics Book
Author : Jose Medina-Franco
Publisher : Academic Press
Release : 2016-02-24
ISBN : 0128028092
Language : En, Es, Fr & De

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Book Description :

Epi-Informatics: Discovery and Development of Small Molecule Epigenetic Drugs and Probes features multidisciplinary strategies with strong computational approaches that have led to the successful discovery and/or optimization of compounds that act as modulators of epigenetic targets. This book is intended for all those using or wanting to learn more about computational methodologies in epigenetic drug discovery, including molecular modelers, informaticians, pharmaceutical scientists, and medicinal chemists. With a better understanding of different molecular modeling and cheminformatic approaches, readers can incorporate these techniques into their own drug discovery projects that may involve chemical synthesis and medium- or high-throughput screening. In addition, this book highlights the significance of epigenetic targets to the public health for molecular modelers and chemoinformatians. The goal of this reference is to stimulate ongoing multidisciplinary research and to further improve current computational methodologies and workflows in order to accelerate the discovery and development of epi-drugs and epi-probes. Focuses on the discovery of epi-drugs as candidates to be used in therapy including combined therapies Describes new computational methodologies and screening assays utilizing recent and emerging novel structural data Highlights the discovery, development and optimization of epi-probes, which are molecular probes that elucidate epigenetic mechanisms Includes important topics such as computational-guided optimization of epi-hits, virtual screening to identify novel compounds for epigenetic targets, development and mining of epigenetic molecular databases, SAR modeling of screening data and much more

Applied Chemoinformatics

Applied Chemoinformatics Book
Author : Thomas Engel,Johann Gasteiger
Publisher : John Wiley & Sons
Release : 2018-06-05
ISBN : 352734201X
Language : En, Es, Fr & De

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Book Description :

Edited by world-famous pioneers in chemoinformatics, this is a clearly structured and applications-oriented approach to the topic, providing up-to-date and focused information on the wide range of applications in this exciting field. The authors explain methods and software tools, such that the reader will not only learn the basics but also how to use the different software packages available. Experts describe applications in such different fields as structure-spectra correlations, virtual screening, prediction of active sites, library design, the prediction of the properties of chemicals, the development of new cosmetics products, quality control in food, the design of new materials with improved properties, toxicity modeling, assessment of the risk of chemicals, and the control of chemical processes. The book is aimed at advanced students as well as lectures but also at scientists that want to learn how chemoinformatics could assist them in solving their daily scientific tasks. Together with the corresponding textbook Chemoinformatics - Basic Concepts and Methods (ISBN 9783527331093) on the fundamentals of chemoinformatics readers will have a comprehensive overview of the field.

Computational Molecular Modelling in Structural Biology

Computational Molecular Modelling in Structural Biology Book
Author : Anonim
Publisher : Academic Press
Release : 2018-08-24
ISBN : 012813917X
Language : En, Es, Fr & De

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Book Description :

Computational Molecular modelling in Structural Biology, Volume 113, the latest release in the Advances in Protein Chemistry and Structural Biology, highlights new advances in the field, with this new volume presenting interesting chapters on charting the Bromodomain BRD4: Towards the Identification of Novel Inhibitors with Molecular Similarity and Receptor Mapping, and Computational Methods to Discover Compounds for the Treatment of Chagas Disease. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Advances in Protein Chemistry and Structural Biology series Updated, with the latest information on Computational Molecular Modelling in Structural Biology

Advances in QSAR Modeling

Advances in QSAR Modeling Book
Author : Kunal Roy
Publisher : Springer
Release : 2017-05-22
ISBN : 3319568507
Language : En, Es, Fr & De

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Book Description :

The book covers theoretical background and methodology as well as all current applications of Quantitative Structure-Activity Relationships (QSAR). Written by an international group of recognized researchers, this edited volume discusses applications of QSAR in multiple disciplines such as chemistry, pharmacy, environmental and agricultural sciences addressing data gaps and modern regulatory requirements. Additionally, the applications of QSAR in food science and nanoscience have been included – two areas which have only recently been able to exploit this versatile tool. This timely addition to the series is aimed at graduate students, academics and industrial scientists interested in the latest advances and applications of QSAR.

Insights into Enzyme Mechanisms and Functions from Experimental and Computational Methods

Insights into Enzyme Mechanisms and Functions from Experimental and Computational Methods Book
Author : Anonim
Publisher : Academic Press
Release : 2016-08-24
ISBN : 0128052414
Language : En, Es, Fr & De

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Book Description :

Insights into Enzyme Mechanisms and Functions from Experimental and Computational Methods is the latest volume in the popular Advances in Protein Chemistry and Structural Biology series, an essential resource for protein chemists. Each volume brings forth new information about protocols and analysis of proteins, with each thematically organized volume guest edited by leading experts in a broad range of protein-related topics. Provides cutting-edge developments in protein chemistry and structural biology Written by authorities in their respective fields Targeted to a wide audience of researchers, specialists, and students

Postgraduate UK study and funding guide

Postgraduate UK study and funding guide Book
Author : Anonim
Publisher : Hotcourses
Release : 2007
ISBN : 9781904735311
Language : En, Es, Fr & De

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Book Description :

Features information on studying at Postgraduate level in the UK, what is involved, what opportunities there are, lists details £75 million of funding available to Postgraduate students.

Repurposed Drugs Targeting Cancer Signaling Pathways Clinical Insights to Improve Oncologic Therapies

Repurposed Drugs Targeting Cancer Signaling Pathways  Clinical Insights to Improve Oncologic Therapies Book
Author : Alma D. Campos-Parra,Carlos Pérez-Plasencia,Teresita Padilla-Benavides,Eduardo López-Urrutia
Publisher : Frontiers Media SA
Release : 2021-08-26
ISBN : 2889712397
Language : En, Es, Fr & De

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Book Description :

Download Repurposed Drugs Targeting Cancer Signaling Pathways Clinical Insights to Improve Oncologic Therapies book written by Alma D. Campos-Parra,Carlos Pérez-Plasencia,Teresita Padilla-Benavides,Eduardo López-Urrutia, available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Evidence Based Validation of Herbal Medicine

Evidence Based Validation of Herbal Medicine Book
Author : Pulok K. Mukherjee
Publisher : Elsevier
Release : 2022-07-12
ISBN : 0323984568
Language : En, Es, Fr & De

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Book Description :

Globalization in the context of drug development has increased the use of natural products worldwide. The trends in use of herbal medicine in therapeutics is becoming more popular and is still open to fascinating realms of research. ‘Evidence-Based Validation of Herbal Medicines’ brings together current thinking and practice in the areas of characterization and validation of natural products. This book describes different approaches and techniques for evaluating the quality, safety and efficacy of herbal medicine, particularly methods to assess their activity and understand the compounds responsible and their probable underlying mechanisms of action, which improve the level of understanding of various aspects on evaluation of natural products. This book is an effort to bring together the views, expertise and experiences of scientific experts in the field of medicinal plant research. This will be useful for the researcher to know more about the natural lead with their validation and also useful to exploit traditional medicines, leading to discovery and development of newer drugs through translational research with cutting edge technologies on natural remedies. This book will be an essential reading for the researchers whose professional life impinges on the use of natural resources. Includes state-of-the-art methods for detecting, isolating, and performing structure elucidation by degradation and spectroscopic techniques Highlights the trends in validation and value addition of herbal medicine with different scientific approaches used in therapeutics Contains several all-new chapters on topics such as traditional-medicine-inspired drug development to treat emerging viral diseases, medicinal plants in antimicrobial resistance, TLC bio profiling, botanicals as medicinal foods, bioprospecting and bioassay-guided isolation of medicinal plants, immunomodulators from medicinal plants, and more

Enzymes Mechanisms Dynamics and Inhibition

Enzymes     Mechanisms  Dynamics and Inhibition Book
Author : Anonim
Publisher : Academic Press
Release : 2020-09-21
ISBN : 0128177632
Language : En, Es, Fr & De

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Book Description :

Enzymes – Mechanisms, Dynamics and Inhibition, Volume 122, the latest release in the Advances in Protein Chemistry and Structural Biology series, highlights new advances in the field, with this new volume presenting new and interesting chapters on the topics. Each chapter is written by an international board of authors. Provides a targeted approach to a very wide audience of specialists, researchers and students Contains timely chapters written by well-renowned authorities in their field Includes a number of high quality illustrations, figures and tables

New Approaches for the Discovery of Pharmacologically Active Natural Compounds

New Approaches for the Discovery of Pharmacologically Active Natural Compounds Book
Author : José L. Medina-Franco
Publisher : MDPI
Release : 2019-07-01
ISBN : 3039211048
Language : En, Es, Fr & De

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Book Description :

A major source of active compounds, natural products from different sources supply a large variety of molecules that have been approved for clinical use or used as the starting points of optimization programs. This book features nine papers (eight full articles and one review paper) written by more than 45 scientists from around the world. These papers illustrate the development and application of a broad range of computational and experimental techniques applied to natural product research. On behalf of the contributors to the book, our hope is that the research presented here contributes to advancements in the field, and encourages multidisciplinary teams, young scientists, and students to further advance in the discovery of pharmacologically-active natural compounds

Salmon Lice

Salmon Lice Book
Author : Simon Jones,Richard Beamish
Publisher : John Wiley & Sons
Release : 2011-08-02
ISBN : 0470961546
Language : En, Es, Fr & De

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Book Description :

The salmon louse Lepeophtheirus salmonis is adapted to survive in hostile marine environments of the northern hemisphere, including an ability to parasitize several species of salmon. Salmonids are some of the most economically important and sought after fish for human consumption, and louse parasitism has a significant impact both on cultured and wild fish populations. Salmon Lice is a timely collection of the latest research on the cause and spread of lice infestations and management techniques being designed and implemented to combat this issue. Salmon Lice provides a thorough single volume review of Lepeophtheirus salmonis, the key parasite standing in the way of sustainable and profitable production of salmonid fishes including salmon, trout and charr. Opening with a review of the biology, morphology, life cycle, and larval behavior of the parasite, Salmon Lice proceeds to review the distribution of planktonic larvae of salmon lice, addresses management techniques used in salmonid aquaculture and capture fisheries, provides a practical assessment of the salmon lice issue and explores potential solutions to the problem. With comprehensive coverage of the biology and distribution of this harmful and ubiquitous parasite, Salmon Lice will be of value to fish health researchers, aquaculture and fisheries professionals, and seafood industry personnel to inform the management of both cultured and wild salmonid populations. Key Features: In-depth coverage of a key parasite impacting viability and sustainability of salmonid fisheries and aquaculture Integrates parasite biology and hydrodynamic models in diverse coastal ecosystems Provides a practical assessment of the salmon louse issue Reviews international salmon louse monitoring and management techniques used in salmonid fisheries and aquaculture

Metaheuristics in Machine Learning Theory and Applications

Metaheuristics in Machine Learning  Theory and Applications Book
Author : Diego Oliva
Publisher : Springer Nature
Release : 2022-10-05
ISBN : 3030705420
Language : En, Es, Fr & De

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Book Description :

This book is a collection of the most recent approaches that combine metaheuristics and machine learning. Some of the methods considered in this book are evolutionary, swarm, machine learning, and deep learning. The chapters were classified based on the content; then, the sections are thematic. Different applications and implementations are included; in this sense, the book provides theory and practical content with novel machine learning and metaheuristic algorithms. The chapters were compiled using a scientific perspective. Accordingly, the book is primarily intended for undergraduate and postgraduate students of Science, Engineering, and Computational Mathematics and is useful in courses on Artificial Intelligence, Advanced Machine Learning, among others. Likewise, the book is useful for research from the evolutionary computation, artificial intelligence, and image processing communities.

Modern CNS Drug Discovery

Modern CNS Drug Discovery Book
Author : Rudy Schreiber
Publisher : Springer Nature
Release : 2021-06-17
ISBN : 3030623513
Language : En, Es, Fr & De

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Book Description :

This textbook provides a comprehensive overview of the currently used concepts, approaches and technologies in the discovery and development of new treatments for the full spectrum of disorders of the central nervous system. It guides the reader through all essential steps, from finding an innovative idea, to the registration of a new drug. Divided into four sections, the book starts by presenting a broad perspective on current approaches in central nervous system (CNS) drug discovery. The second section addresses the generation of ideas for the identification of targets and novel treatment strategies; covers core functions in early discovery, and provides an example of a novel treatment paradigm: brain stimulation. The third section highlights strategies and technologies in translational CNS drug discovery. In an effort to bridge the gap between discovery and clinical development, it also covers brain imaging, EEG and cognitive testing approaches. The fourth section extensively discusses the clinical phase of drug development, covering the basics of early clinical testing for psychopharmacological drugs. The book’s final chapter addresses the registration for newly developed drugs. Written by experts from academia and industry, the book covers important basics and best practices, as well as recent developments in drug discovery. Offering in-depth insights into the world of drug development, it represents essential reading for early researchers who want to prepare for a career in drug discovery in academia or industry.

Epi Info and OpenEpi in Epidemiology and Clinical Medicine

Epi Info and OpenEpi in Epidemiology and Clinical Medicine Book
Author : Andrew G. Dean,Kevin M. Sullivan,Minn Minn Soe
Publisher : Createspace Independent Pub
Release : 2010-02
ISBN : 9781449538910
Language : En, Es, Fr & De

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Book Description :

Epi Info is a free computer program from the Centers for Disease Control and Prevention(CDC), downloaded 2 million times since 1998, and referred to in over 1 million web pages. It allows anyone with a computer to design a questionnaire, enter data, and do tabulation and statitistical analysis. This book tells how to use Epi Info for rapid surveys and research studies and for constructing electronic medical records, public health surveillance systems. graphs, and maps. Sample programs can be downloaded from the web.

Wikipedia Handbook of Biomedical Informatics

Wikipedia Handbook of Biomedical Informatics Book
Author : Anonim
Publisher : PediaPress
Release : 2022-10-05
ISBN : 0987650XXX
Language : En, Es, Fr & De

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Book Description :

Download Wikipedia Handbook of Biomedical Informatics book written by , available in PDF, EPUB, and Kindle, or read full book online anywhere and anytime. Compatible with any devices.

Microbial and Natural Macromolecules

Microbial and Natural Macromolecules Book
Author : Surajit Das,Hirak Ranjan Dash
Publisher : Academic Press
Release : 2020-09-15
ISBN : 0128200855
Language : En, Es, Fr & De

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Book Description :

Microbial and Natural Macromolecules: Synthesis and Applications brings together active scientists and academicians in the field who share updated information and research outcomes from global experts. Microbial macromolecular diversity, molecular composure, genetics, usability of advanced molecular tools and techniques for their study as well as their applicability are discussed with detailed research perspectives. Illustrates fundamental discoveries and methodological advancements Discusses novel functional attributes of macromolecules Updates progress on microbial macromolecular research

Drug Selectivity

Drug Selectivity Book
Author : Norbert Handler,Helmut Buschmann,Raimund Mannhold,Jörg Holenz
Publisher : John Wiley & Sons
Release : 2018-02-05
ISBN : 3527335382
Language : En, Es, Fr & De

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Book Description :

The book provides a current overview and comprehensive compilation for medicinal chemists that discusses the effects of aiming for multiple targets on the entire drug development process. The result is a broad survey of current and future strategies for drug selectivity in medicinal chemistry with theoretical but also practical aspects. Different strategies are presented and evaluated, such as various design approaches, merged multiple ligands, discovery technologies and a broad range of successful examples of unselective drugs taken from all major disease areas. With its wide-ranging view of an emerging new paradigm in drug development, this handbook is of prime importance for every medicinal and pharmaceutical chemist.

DNA Methyltransferases Role and Function

DNA Methyltransferases   Role and Function Book
Author : Albert Jeltsch,Renata Z. Jurkowska
Publisher : Springer
Release : 2016-11-08
ISBN : 3319436244
Language : En, Es, Fr & De

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Book Description :

DNA methyltransferases are important enzymes in a broad range of organisms. Dysfunction of DNA methyltransferases in humans leads to many severe diseases, including cancer. This book focuses on the biochemical properties of these enzymes, describing their structures and mechanisms in bacteria, humans and other species, including plants, and also explains the biological processes of reading of DNA methylation and DNA demethylation. It covers many emerging aspects of the biological roles of DNA methylation functioning as an essential epigenetic mark and describes the role of DNA methylation in diseases. Moreover, the book explains modern technologies, like targeted rewriting of DNA methylation by designed DNA methyltransferases, as well as technological applications of DNA methyltransferases in DNA labelling. Finally, the book summarizes recent methods for the analysis of DNA methylation in human DNA. Overall, this book represents a comprehensive state-of-the-art- work and is a must-have for advanced researchers in the field of DNA methylation and epigenetics.

Fish Parasites

Fish Parasites Book
Author : Patrick T. K. Woo,Kurt Buchmann
Publisher : CABI
Release : 2012
ISBN : 1845938062
Language : En, Es, Fr & De

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Book Description :

Focusing on pathobiology and protective strategies against protozoan and metazoan parasites of fish, this book reviews the latest research on important parasites: those that cause financial hardships to the aquaculture industry, have been introduced to new geographical regions through transportation of infected fish, are pathogenic to groups of finfish and detrimental to production, are highly adaptable and not host-specific with worldwide distributions, and that may serve as disease models for studies on other pathogens. It also highlights gaps in the knowledge to help direct future research.

Recent Advances in Animal Virology

Recent Advances in Animal Virology Book
Author : Yashpal Singh Malik,Raj Kumar Singh,Mahendra Pal Yadav
Publisher : Springer Nature
Release : 2019-11-14
ISBN : 9811390738
Language : En, Es, Fr & De

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Book Description :

This book discusses the prominence and implication of the viral diseases that are a major threat to animals around the globe. A number of these diseases have also shown links with human populations, which has implications for public health. This book offers detailed and up-to-date information on viral diseases in livestock and poultry that were and/or are still a problem. Including cutting-edge developments, it also highlights several landmark contributions in the field of virology from India. Additionally, the book features tables and figures showing important clinical data and recommendations, with references for further information. It also explores the economic impact of viral diseases for farmers and the livestock industry, providing several examples. Further, it presents the latest information on viral diseases in global context, with a focus on state-of-art, molecular tools for the development of diagnostics, prophylactics and therapeutics. Lastly, the book also describes the challenges posed by the emerging and transboundary viral infections and our preparedness to counter them.