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Eosinophil Ultrastructure

Eosinophil Ultrastructure Book
Author : Rossana C.N. Melo,Ann M. Dvorak,Peter F. Weller
Publisher : Academic Press
Release : 2021-05-01
ISBN : 0128137568
Language : En, Es, Fr & De

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Book Description :

Eosinophil Ultrastructure: Atlas of Eosinophil Cell Biology and Pathology focuses on eosinophils and their functional roles in inflammation, host defense and normal homeostatic activities. The book explores the ultrastructure of human eosinophils, highlighting biological processes observed in normal, experimental and pathological conditions. Created to fill a void in the eosinophil literature, this book has an extensive array of electron microscopic images that illustrate the diversity of eosinophil morphology. While the atlas is primarily a learning and teaching tool, it also acts as a helpful resource for researchers who want to identify distinguishing features and structural changes that arise during studies of human eosinophils. Helps readers understand human eosinophils in studies focused on structural biology, cellular immunology, innate and adaptive immunity, immune responses to pathogens, immunopathology and inflammatory responses Provides a core of essential knowledge to identify both immature and mature eosinophils Comprises a representative compilation of the eosinophil ultrastructure during biological processes, such as activation and degranulation, observed mostly in experimental conditions Highlights eosinophil biological processes found in vivo during human diseases, thus providing a link between basic science and clinical aspects Helps identify distinguishing features and structural changes that arise during studies of human eosinophils in culture

Pathogenic Advances and Therapeutic Perspectives for Eosinophilic Inflammation

Pathogenic Advances and Therapeutic Perspectives for Eosinophilic Inflammation Book
Author : Florence E. Roufosse,Mats W. Johansson
Publisher : Frontiers Media SA
Release : 2018-12-06
ISBN : 2889456242
Language : En, Es, Fr & De

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Book Description :

With the recent approval of the first eosinophil-depleting therapeutic agents targeting the IL-5 pathway for treatment of severe eosinophilic asthma, eosinophils and eosinophilic disorders are in the limelight. Indeed, setbacks during clinical development of these compounds have revealed how much remains to be known about eosinophil biology in vivo, and have nurtured profuse research both on basic eosinophil biology and on pathogenic disease mechanisms, in order to better delineate the most meaningful targets for innovative therapeutic strategies. On one hand, variable degrees of eosinophil depletion observed in some compartments during IL-5-targeted treatment indicate that certain eosinophil subsets may not rely on this cytokine and/or that other important pro-eosinophilic mediators and signaling pathways are operative in vivo. On the other hand, it is increasingly clear that disorders involving eosinophils such as asthma are the final outcome of complex interactions between diverse cell types and mediators, beyond eosinophils and IL-5. These include type 2 helper T (Th2) cells and innate lymphoid cells, mast cells, and a variety of factors that either activate eosinophils or are released by them. Although a considerable amount of research has focused on asthma because it is a common condition and because management of severe asthma remains a major challenge, several rare eosinophilic disorders with more homogenous features have proven to be extremely useful models to reach a better understanding of the involvement of eosinophils in tissue damage and dysfunction, and of the micro-environmental interactions operating within the complex network of eosinophilic inflammation. Unraveling this interplay has resulted in advances in the development of molecular tools to detect disease subsets and to monitor therapeutic responses, and in identification of promising new therapeutic targets. This Research Topic dedicated to eosinophilic conditions covers aspects of the biology of eosinophils and closely related cells of particular relevance for drug development, reports on translational research investigating pathogenic mechanisms of specific eosinophilic disorders in humans that will likely result in significant changes in the way patients are managed, and presents an overview of the current advancement of targeted drug development for these conditions, with a special focus on asthma.

Functional Ultrastructure

Functional Ultrastructure Book
Author : Margit Pavelka,Jürgen Roth
Publisher : Springer Science & Business Media
Release : 2005-12-05
ISBN : 3211263926
Language : En, Es, Fr & De

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Book Description :

The period between 1950 and 1980 were the golden It also provides unique insights into how pathological years of transmission electron microscopy and pro- processes affect cell organization. duced a plethora of new information on the structure of This information is vital to current work in which cells that was coupled to and followed by biochemical the emphasis is on integrating approaches from p- and functional studies. TEM was king and each micro- teomics, molecular biology, molecular imaging and graph of a new object produced new information that physiology, and pathology to understand cell functions led to new insights on cell and tissue organization and and derangements in disease. In this current era, there is their functions. The quality of data represented by the a growing tendency to substitute modern light mic- images of cells and tissues had been perfected to a very scopic techniques for electron microscopy because it is high level by the great microscopists of the era including less technically demanding and is more readily available Palade, Porter, Fawcett, Sjostrand, Rhodin and many to researchers. This atlas reminds us that the infor- others. At present, the images that we see in leading tion obtained by electron microscopy is invaluable and journals for the most part do not reach the same techni- has no substitute.

Eosinophils in Health and Disease

Eosinophils in Health and Disease Book
Author : James J. Lee,Helene F. Rosenberg
Publisher : Academic Press
Release : 2012
ISBN : 012394385X
Language : En, Es, Fr & De

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Book Description :

Eosinophils in Health and Disease provides immunology researchers and students with a comprehensive overview of current thought and cutting-edge eosinophil research, providing chapters on basic science, disease-specific issues, therapeutics, models for study and areas of emerging importance.

Megakaryocytes Platelets Macrophages and Eosinophils

Megakaryocytes  Platelets  Macrophages  and Eosinophils Book
Author : J. Robin Harris
Publisher : Springer Science & Business Media
Release : 1991-01-31
ISBN : 9780306435447
Language : En, Es, Fr & De

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Book Description :

Blood Cell Biochemistry was initially conceived as part of the Plenum series Subcellular Biochemistry, from which it has developed into a separate series. The present volume is devoted primarily to contributions on megakaryocytes and platelets and, to a lesser extent, to macrophages and eosinophils. The book does not attempt a rigorous or total coverage of the particular topics; it represents the areas of current scientific activity and interest that were selected by the editor at the commencement of this project. In general, the approach has been similar to that adopted for Volume 1 of the series (Erythroid Cells); the same approach will be followed subsequently in Volume 3 (Lymphocytes and Granulocytes). This book opens with a developmentally oriented chapter by Janine Breton-Gorius on megakaryocyte maturation and platelet release in normal conditions, which serves to set the scene ultrastructurally for much of the data that follow. The biosynthesis and process­ ing of platelet glycoproteins in megakaryocytes is dealt with by Alain Duperray and his colleagues, and thereby provides an in-depth biochemical survey of the megakaryocyte. The applications and strengths of crossed immunoelectrophoresis for the study of platelet membrane proteins is then covered by Simon Karpatkin, and a detailed account of the heredity disorders of platelet function is provided by Francine Rendu and Evelyne Dupuy.

Ultrastructural Pathology

Ultrastructural Pathology Book
Author : Norman F. Cheville
Publisher : John Wiley & Sons
Release : 2009-12-09
ISBN : 0813810345
Language : En, Es, Fr & De

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Book Description :

Ultrastructural Pathology, Second Edition is a comprehensive reference on electron microscopy of pathologic tissue in animals and humans. The text bridges the gap between what is seen in the electron microscope at the cellular level with what the pathologist encounters in the postmortem room. It explains and integrates all aspects of ultrastructural pathology in human and animal tissue occurring from natural and experimental disease. This new edition has been improved with a more comparative focus and expanded coverage on infectious diseases and tumors.

Allergy and Allergic Diseases

Allergy and Allergic Diseases Book
Author : Judah A. Denburg
Publisher : Springer Science & Business Media
Release : 2013-03-09
ISBN : 1475727763
Language : En, Es, Fr & De

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Book Description :

Allergy and Allergic Diseases has been organized to provide an up-to-date, clinically relevant compilation of one of the most exciting areas of investigation in medicine today-allergic disease, especially as it pertains to the skin, airways, and bowel. With the dramatic rise in the incidence of various allergic disorders worldwide, and the coming of age of the discipline of Clinical Immunology and Allergy, the interface between basic and clinical science in this arena demands highlighting in this comprehensive new syn thesis.1t is with the hope of filling this evident need that Allergy and Allergic Diseases: The New Mechanisms and Therapeutics has been put together. The book's content is divided into both basic and clinical sections, with emphasis on various components of the immune and inflammatory response as they relate to the development of allergic disease. Topics span the range from molecular biology to clinical symptomatology, with an effort to make this of interest to as broad a constituency as possible. This book will therefore be of substantial interest to specialists in Clinical Immunology and Allergy, scientists studying the cellular and molecular biology of in flammation and immunity, as well as internists, teachers, developers of medical school curricula, and members of industry focused on drug discovery and therapeutics. Indeed, a separate section has been added to deal with some specific issues in this latter field.

Eosinophils in Allergy and Inflammation

Eosinophils in Allergy and Inflammation Book
Author : Gerald J. Gleich
Publisher : CRC Press
Release : 1993-11-09
ISBN : 9780824791216
Language : En, Es, Fr & De

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Book Description :

This work presents the proceedings of a conference held at Adare Manor, County Limerick, Ireland. It provides an updated, in-depth review of the biological role of eosinophils in allergic diseases, summarizing basic knowledge of these unique cationic proteins. The book features an annotated discussion of the conference's post-presentation question-and-answer session.

Blood and Bone Marrow Pathology E Book

Blood and Bone Marrow Pathology E Book Book
Author : Anna Porwit,Jeffrey McCullough,Wendy N Erber
Publisher : Elsevier Health Sciences
Release : 2011-05-27
ISBN : 0702045357
Language : En, Es, Fr & De

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Book Description :

Chapters have been totally rewritten and some new chapters have been added especially on myeloid malignancies, in line with the WHO 2008 Classification All chapters have been revised to include new aspects of molecular biology and updated concerning flow cytometry diagnostics Greater emphasis on practical diagnostic aspects for all disorders Brand new editorial and contributing author team. Full Online text through Expert Consult. Full downloadable Image Bank

Ultrastructure of Reproduction

Ultrastructure of Reproduction Book
Author : Jonathan van Blerkom,P. Motta
Publisher : Springer Science & Business Media
Release : 2012-12-06
ISBN : 1461338670
Language : En, Es, Fr & De

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Book Description :

Advances in the development and application of electron microscopic techniques have occurred recently such that the electron microscope has evolved to become an essential tool in both basic and clinical research. Use of this instrument has contributed significantly to the formation of new perspectives and concepts concerning cell fine structure. These structural perspectives are now being integrated with specific functional, biochemical and pathophysiological events and processes of cells and tissues. Most recently, utilization of innovative electron microscopic techniques such as freeze-fracture, freeze etching, and scanning and high-voltage electron microscopy offers both the basic and clinical scientist potentially fundamental insights into many morphodynamic processes related to the activities of cells and tissues. Such an approach has been especially rewarding when applied to the dynamic events of gametogenesis and early embryonic development. The chapters comprising this book have been selected and edited with the aim of providing an up-to-date and comprehensive account of the most important aspects of vertebrate gamets and embryos as revealed by the integration of several different submicroscopic methods. The organization of the chapters is designed to indicate present gaps in our knowledge of the developmental and reproductive biology of gametes and the developing embryo and possible Iines of research which may lead to a lessening of these gaps.

Eosinophils

Eosinophils Book
Author : Christopher J. F. Spry
Publisher : Oxford University Press, USA
Release : 1988
ISBN :
Language : En, Es, Fr & De

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Book Description :

Cell biology and biochemical studies have shown how eosinophils respond to external stimuli, take part in inflammation, damage parasites, and often harm normal cells, especially in the heart.This book reviews exciting developments in eosinophil research, showing how new knowledge could be applied to current research and clinical practice. Over 2000 references are included, from a database of over 5000 used, forming the most thorough review of the literature currently available.

Basophil and Mast Cell Degranulation and Recovery

Basophil and Mast Cell Degranulation and Recovery Book
Author : Ann M. Dvorak
Publisher : Springer Science & Business Media
Release : 2013-06-29
ISBN : 1475795254
Language : En, Es, Fr & De

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Book Description :

Basophils and mast cells are similar but unique secretory cells with a well-documented role in immediate-hypersensitivity reactions. The presence of these cells in various cell mediated hypersensitivity reactions, in tissues of multiple diseases, and as a component of the host reaction to injury and repair in numerous circumstances is well known. Release of stored and newly generated mediators of inflammation from basophils and mast cells contributes to the cascade of pathogenetic events in circumstances under which these release reactions occur. Despite insights acquired through studies of these pathologic events, the role of basophils and mast cells and their secretory products in health is not known. In this book, I review much of the structural information regarding basophils and mast cells of multiple species. Ultrastructural studies of rat mast cells historically precede and quantitatively exceed similar studies of basophils and mast cells of other species. Therefore, I first review these background studies as an entity. Then I discuss the contents of two prominent organelles-granules and lipid bodies-in basophils and mast cells of several species. The ultrastructural morphology of basophils and mast cells in three species is presented in detail to establish appropriate guidelines for their recognition and to provide general rules for analysis which are appropriate for the identification of these cells in other species as well.

Murray and Nadel s Textbook of Respiratory Medicine E Book

Murray and Nadel s Textbook of Respiratory Medicine E Book Book
Author : Robert J. Mason,V.Courtney Broaddus,Thomas R Martin,Talmadge E King,Dean Schraufnagel,John F. Murray,Jay A. Nadel
Publisher : Elsevier Health Sciences
Release : 2010-06-09
ISBN : 1437735533
Language : En, Es, Fr & De

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Book Description :

Murray and Nadel’s Textbook of Respiratory Medicine has long been the definitive and comprehensive pulmonary disease reference. Robert J. Mason, MD now presents the fifth edition in full color with new images and highlighted clinical elements. The fully searchable text is also online at www.expertconsult.com, along with regular updates, video clips, additional images, and self-assessment questions. This new edition has been completely updated and remains the essential tool you need to care for patients with pulmonary disease. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Compatible with Kindle®, nook®, and other popular devices. Master the scientific principles of respiratory medicine and its clinical applications. Work through differential diagnosis using detailed explanations of each disease entity. Learn new subjects in Pulmonary Medicine including Genetics, Ultrasound, and other key topics. Grasp the Key Points in each chapter. Search the full text online at expertconsult.com, along with downloadable images, regular updates, more than 50 videos, case studies, and self-assessment questions. Consult new chapters covering Ultrasound, Innate Immunity, Adaptive Immunity, Deposition and Clearance, Ventilator-Associated Pneumonia. Find critical information easily using the new full-color design that enhances teaching points and highlights challenging concepts. Apply the expertise and fresh ideas of three new editors—Drs. Thomas R. Martin, Talmadge E. King, Jr., and Dean E. Schraufnagel. Review the latest developments in genetics with advice on how the data will affect patient care.